V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

HCK Gene

protein-coding GIFtS: 72

GC20P030103

hemopoietic cell kinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.2 ^³
JTK9 ^¹, ²
p59-HCK/p60-HCK ^³

Descriptions
hemopoietic cell kinase ^², ³
tyrosine protein kinase HCK ^²

External Ids
HGNC: 4840¹
Entrez Gene: 3055²
UniProtKB: P08631³
Ensembl: ENSG00000101336⁷

Search outside databases for aliases for HCK gene

Previous GC identifers: GC20P030428 GC20P031338 GC20P031385

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HCK:

The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in

hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of

the respiratory burst. In addition, it may play a role in neutrophil migration and in the

degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG

(CUG) codon, results in the production of two different isoforms, that have different subcellular

localization. [provided by RefSeq]

UniProtKB/Swiss-Prot: HCK_HUMAN, P08631

Function: May serve as part of a signaling pathway coupling the Fc receptor to the activation of

the respiratory burst. May also contribute to neutrophil migration and may regulate the

degranulation process of neutrophils

Gene Wiki entry for HCK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HCK gene

Entrez Gene cytogenetic band: 20q11-q12 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11-q12

HCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P030103: (about GC identifiers)

Start:	30,103,706 bp from pter
End:	30,153,320 bp from pter
Size:	49,615 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_028392.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: HCK_HUMAN, P08631 (See protein sequence)

Recommended Name: Tyrosine-protein kinase HCK

Size: 526 amino acids; 59600 Da

Subunit: May interact (via SH3 domain) with HIV-1 Nef and Vif. This interaction would stimulates

its tyrosine-kinase activity. Interacts (via SH3 domain) with HEV ORF3 protein

Subcellular location: Isoform p59-HCK: Membrane; Lipid-anchor

Subcellular location: Isoform p60-HCK: Membrane; Lipid-anchor. Cytoplasm

Sequence caution: Sequence=AAA52643.1; Type=Frameshift; Positions=20;

PDB structures from and Proteopedia :

1AD5 (3D)

1BU1 (3D)

1QCF (3D)

2C0I (3D)

2C0O (3D)

2C0T (3D)

2HCK (3D)

2HK5 (3D)

2OI3 (3D)

2OJ2 (3D)

3HCK (3D)

4HCK (3D)

5HCK (3D)

Secondary accessions: Q29RX1 Q2VPE2 Q504R5 Q5T7K1 Q5T7K2 Q96CC0 Q9H5Y5 Q9NUA4 Q9UMJ5

Alternative initiation: 2 isoforms: P08631-1 P08631-2

Post-translational modifications:

Isoform p59-HCK contains a N-myristoyl glycine at position 3 (By similarity). Isoform p59-HCK

contains a S-palmitoyl cysteine at position 3 (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002101.2

ENSEMBL proteins:

ENSP00000365012 ENSP00000262651 ENSP00000365022

Human Recombinant Proteins

	Invitrogen human recombinant proteins for HCK
	Millipore Purified and/or Recombinant HCK Protein
	Sigma-Aldrich Proteins for HCK
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for HCK
	Recombinant Proteins from Abcam (Hck)
	Human Recombinant Proteins from Abnova (HCK)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0016020	membrane	IEA	--

About this table

Antibodies for HCK:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of HCK
	Sigma-Aldrich Antibodies for HCK
	R&D Systems Antibodies for HCK
	Cell Signaling Technology (CST) Antibodies for HCK
	Antibodies from Abcam (Hck), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HCK)
	Novus Biologicals Antibodies for HCK

Assays for HCK:

	Invitrogen Assays for HCK
	Millipore Kits and Assays for the Analysis of HCK
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08631

ProtoNet protein and cluster: P08631

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: HCK_HUMAN, P08631

Domain: The SH3 domain mediates binding to HIV-1 Nef

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH2 domain

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HCK)
		Millipore RNAi Products for the Analysis of HCK Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (HCK)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002110

Applied Biosystems Silencer® siRNAs for HCK

Sigma-Aldrich siRNA and siRNA Panels for HCK

Sigma-Aldrich shRNA Panels and shRNA for HCK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002110
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002110
untagged cDNA clones in CMV expression vector (see all 3): NM_002110

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002110

UniProtKB/Swiss-Prot: HCK_HUMAN, P08631

Function: May serve as part of a signaling pathway coupling the Fc receptor to the activation of

the respiratory burst. May also contribute to neutrophil migration and may regulate the

degranulation process of neutrophils

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.2

Genatlas biochemistry entry for HCK:

hemopoietic cell kinase

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hck):

	growth/size	hematopoietic system	homeostasis/metabolism	immune system
lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	respiratory system	skeleton
tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	--
GO:0005515	protein binding	IPI	7859737 12029088
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for HCK (Your Favorite Gene powered by Ingenuity)

GM-CSF Signaling
Fc&gamma
Reelin Signaling in Neurons

GeneDecks HCK for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HCK

5/128 Interacting proteins for HCK (ENSP00000262651³ P08631^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 128 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELMO1	Q92556¹	STRING (score=.963) EBI-346340, EBI-346417
LCP2	Q13094¹	STRING (score=.752) EBI-346340, EBI-346946
SH3KBP1	Q96B97¹	STRING (score=.758) EBI-346340, EBI-346595
WAS	P42768¹	STRING (score=.983) EBI-346340, EBI-346375
WIPF1	O43516¹	STRING (score=.722) EBI-346340, EBI-346356

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	TAS	3496523
GO:0007498	mesoderm development	TAS	3453117
GO:0044419	interspecies interaction between organisms	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for HCK

Browse Small Molecules at Sigma-Aldrich

Compounds for HCK available from Tocris Bioscience
10/17 Novoseek chemical compound relationships for HCK gene (see all 17 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	80.90	134	11106432 (5), 15752743 (3), 9642231 (3), 19234535 (3) (see all 85)
gp 130	54.37	10	11689697 (3), 8156996 (2), 8939963 (2), 17310994 (2)
mdms	52.90	1	11493626 (1)
proline	48.03	2	12525647 (1), 10364375 (1)
phosphotyrosine	47.95	4	9642231 (2)
zymosan	36.90	6	8995234 (4), 17173331 (1)
hgcl2	22.58	5	11106432 (4)
phosphatidylinositol	17.20	4	10799548 (3)
fmlp	10.84	2	17339487 (2)
phenylalanine	0.00	1	8156996 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HCK)
		Millipore RNAi Products for the Analysis of HCK Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (HCK)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002110

Sigma-Aldrich siRNA and siRNA Panels for HCK

Sigma-Aldrich shRNA Panels and shRNA for HCK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002110

REFSEQ mRNAs for HCK gene:

NM_002110.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002110

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002110
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002110
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002110

Additional cDNA sequence:

AK026432.1 AK225819.1 AK289896.1 AK290928.1 AK298726.1 AK314335.1 BC014435.1 BC073748.1

BC094847.1 BC108930.1 BC108931.1 BC113854.1 BC114463.1 CR594271.1

6 DOTS entries:

DT.311472 DT.100659852 DT.120799457 DT.97780462 DT.444878 DT.95165612

24/82 AceView cDNA sequences (see all 82 ):

BI905929 AW452008 BQ062291 BC073748 NM_002110 N59457 AA632353 AI912730

BE670668 CD671491 AK026432 BQ706242 CD672015 CD672014 CD671492 AL543079

BX093144 BE552057 CR594271 AW450367 AW473073 BF222829 BP372970 BC014435

highest scoring ESTs for HCK:

AA149096 AA149097 AA632353 AA676644 AI193645 AI220607 AI351472 AI458570 AI572095 AI656881

Unigene Cluster for HCK:

Hemopoietic cell kinase

Hs.655210 [show with all ESTs]

Unigene Representative Sequence: AK290928

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for HCK

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15
SP1:							-		-
SP2:							-		-
SP3:							-
SP4:									-

About this scheme

ECgene alternative splicing isoforms for HCK

3 Ensembl transcripts including schematic representations:

ENST00000375852 ENST00000262651 ENST00000375862

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HCK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HCK

¹ / ² / ³

4 probe-sets matching HCK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40742_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.95	M16591	0.60	1.00	0.82	1
2045_s_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.06	M16592	0.80	1.00	0.91	1
208018_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002110	0.60	1.00	0.82	1
208018_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HCK for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATAGGGAGGA

SOURCE GeneReport for Unigene cluster: Hs.655210
Expression variation in blood from EXPOLDB for HCK
UniProtKB/Swiss-Prot: HCK_HUMAN, P08631
Tissue specificity: Expressed predominantly in cells of the myeloid and B-lymphoid lineages

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HCK gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HCK¹	--	hemopoietic cell kinase	89.82(n) 91.79(a)	485828 XM_542952.2 XP_542952.2
chimpanzee (Pan troglodytes)	HCK¹	--	hemopoietic cell kinase	98.27(n) 97.88(a)	458163 XM_514571.2 XP_514571.2
rat (Rattus norvegicus)	Hck¹	--	hemopoietic cell kinase	86.51(n) 89.89(a)	25734 NM_013185.2 NP_037317.2
mouse (Mus musculus)	Hck^{1, 5}	2 (86.00 cM)⁵	hemopoietic cell kinase^{1, 5}	86.7(n)¹ 90.08(a)¹	15162¹ NM_010407.3¹ NP_034537.2¹ AI849071⁵ AK149736⁵ (see all 19)
chicken (Gallus gallus)	HCK¹	--	hemopoietic cell kinase	75(n) 77.8(a)	419280 XM_417454.2 XP_417454.2

About this table Species with no ortholog for HCK

ENSEMBL Gene Tree for HCK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HCK gene

LCK² BLK² LYN²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/363 NCBI SNPs in HCK are shown (see all 363 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 102)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1004910^1,2	A,C,F,H	30103091(-)	`TATACC/AGCCGG`	1	--	ng5¹		14	MN EU EA WA NA	1518
	rs17093828^1,2	F,H	30152907(+)	`GCGGCC/AGACCT`	1	Q/P	mis¹ ese³		7	NA EU EA WA	540
	rs6089166^1,2	H	30125246(+)	`CCTCAG/TCTTCC`	1	S/I	mis¹ ese³		4	EU EA WA	412
	rs6089165^1,2	H	30123182(+)	`AAAAAC/TTGAAA`	1	T/I	mis¹		4	EU EA WA	418
--	rs17093775^1,2	F	30103025(+)	`ACTGTG/AGCAGG`	1	--	ng5¹		2	MN EA	356
--	rs2227979^1,2	F,O	30135979(+)	`CTTGGC/TGCTGG`	2	G/G	syn¹		1	MN	66
	rs34774796^1,2	C,F	30123198(-)	`TGTGGG/ACTGGC`	1	S/S	syn¹		1	NA	76
	rs2227967^1,2	F	30125235(+)	`CACCAC/TGAAGA`	1	H/H	syn¹		1	MN	66
	rs6061156^1,2	H	30138096(+)	`GCCACC/TTACAA`	1	T/T	syn¹ ese³		4	EU EA WA	420
	rs6058524^1,2	H	30135470(+)	`AGCACC/TTTCAG`	1	T/T	syn¹ ese³		4	EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for HCK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 142370

9 Novoseek disease relationships for HCK gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	56.02	3	17344919 (1), 16546576 (1), 9390404 (1)
immunodeficiency	37.36	13	10473622 (2), 9621101 (2), 9218412 (1), 15613341 (1) (see all 7)
myeloid leukemia	26.62	1	10849448 (1)
lymphoblastic leukemia acute	16.80	7	10720701 (2), 10658677 (2), 17344919 (1)
aids	14.48	4	17893228 (1), 15595833 (1), 16352531 (1), 17920628 (1)
leukemia	12.19	3	17344919 (2), 18538446 (1)
tumors	3.77	3	17344919 (1), 19211505 (1), 12237848 (1)
cancer	2.24	1	7690925 (1)
necrosis	0.00	1	12237848 (1)

About this table

Human Gene Mutation Database: HCK
Human Genome Epidemiology Navigator: HCK (1 document)
Tumor Gene Database: HCK

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/259 PubMed articles for HCK gene (see all 259 ):

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. (PubMed id 3496523)^{2, 3, 4} Quintrell N.... Rowley J.D. (1987)
The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein. (PubMed id 11278465)^{1, 3, 4} Hassaine G.... Decroly E. (2001)
SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1. (PubMed id 9218412)^{1, 3, 4} Briggs S.D.... Smithgall T.E. (1997)
Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization. (PubMed id 1875927)^{1, 3, 4} Lock P.... Dunn A.R. (1991)
Solution structure of the human Hck SH3 domain and identification of its ligand binding site. (PubMed id 9571048)^{1, 3, 4} Horita D.A.... Byrd R.A. (1998)
The genomic locus of the human hemopoietic-specific cell protein tyrosine kinase (PTK)-encoding gene (HCK) confirms conservation of exon-intron structure among human PTKs of the src family. (PubMed id 1572549)^{1, 3, 4} Hradetzky D.... Ruesamen-Waigmann H. (1992)
RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef. (PubMed id 9778343)^{1, 3, 4} Arold S....Ladbury J.E. (1998)
Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase. (PubMed id 9109402)^{1, 3, 4} Zhang W.... Gmeiner W.H. (1997)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3055	HGNC: 4840	AceView: HCK	Ensembl:ENSG00000101336	euGenes: HUgn3055
ECgene: HCK	H-InvDB: HCK

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for HCK	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for HCK
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HCK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HCK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HCK		Antibodies for HCK
	Explore super-pooled esiRNAs		Proteins for HCK
	Lentivirus-delivered shRNAs for HCK		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HCK)
	Antibodies (HCK)
	Chimera RNAi (HCK)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for HCK

	Recombinant Proteins (Hck)
	Antibodies (Hck)

Search OriGene for HCK

Tocris compounds for HCK

	Drugs/Proteins for HCK
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HCK

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
HCK Gene at Home site.
Version 2.41.1
server5.xennexinc.com

HCK Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for HCK

Summaries
for HCK

Genomic Location
for HCK

Proteins
for HCK

Protein Domains/
Families
for HCK

Gene Function
for HCK

Pathways & Interactions
for HCK

Drugs & Compounds
for HCK

Transcripts
for HCK

Expression
for HCK

Orthologs
for HCK

Paralogs
for HCK

SNPs/Variants
for HCK

Disorders & Mutations
for HCK

Medical News
for HCK

Publications
for HCK

Search for HCK

Genome Databases showing HCK

Other Databases showing HCK

Specialized Databases showing HCK

Licensable Technologies
for HCK

Services
for HCK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HCK Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor HCK

Summariesfor HCK

Genomic Locationfor HCK

Proteinsfor HCK

Protein Domains/Familiesfor HCK

Gene Functionfor HCK

Pathways & Interactionsfor HCK

Drugs & Compoundsfor HCK

Transcriptsfor HCK

Expression for HCK

Orthologsfor HCK

Paralogsfor HCK

SNPs/Variantsfor HCK

Disorders & Mutationsfor HCK

Medical Newsfor HCK

Publicationsfor HCK

Search for HCK

Genome Databases showing HCK

Other Databases showing HCK

Specialized Databases showing HCK

Licensable Technologiesfor HCK

Servicesfor HCK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HCK

Summaries
for HCK

Genomic Location
for HCK

Proteins
for HCK

Protein Domains/
Families
for HCK

Gene Function
for HCK

Pathways & Interactions
for HCK

Drugs & Compounds
for HCK

Transcripts
for HCK

Expression
for HCK

Orthologs
for HCK

Paralogs
for HCK

SNPs/Variants
for HCK

Disorders & Mutations
for HCK

Medical News
for HCK

Publications
for HCK

Licensable Technologies
for HCK

Services
for HCK