Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HCK Gene

Aliases for HCK Gene

  • HCK Proto-Oncogene, Src Family Tyrosine Kinase 2 3 5
  • Hemopoietic Cell Kinase 2 3 4
  • Hematopoietic Cell Kinase 3 4
  • P59-HCK/P60-HCK 3 4
  • EC 2.7.10.2 4 61
  • P59Hck 3 4
  • P61Hck 3 4
  • Tyrosine-Protein Kinase HCK 3
  • EC 2.7.10 61
  • JTK9 3

External Ids for HCK Gene

Previous GeneCards Identifiers for HCK Gene

  • GC20P030428
  • GC20P031338
  • GC20P031385
  • GC20P030103
  • GC20P030641
  • GC20P027428
  • GC20P030645
  • GC20P030648
  • GC20P030652

Summaries for HCK Gene

Entrez Gene Summary for HCK Gene

  • The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

GeneCards Summary for HCK Gene

HCK (HCK Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with HCK include Hiv-1 and Flying Phobia. Among its related pathways are CXCR4-mediated signaling events and IL6-mediated signaling events. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LYN.

UniProtKB/Swiss-Prot for HCK Gene

  • Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.

Gene Wiki entry for HCK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCK Gene

Genomics for HCK Gene

Regulatory Elements for HCK Gene

Enhancers for HCK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F032033 1.5 FANTOM5 Ensembl ENCODE 19.1 -16.8 -16788 4.0 CTCF ZNF146 ESRRA PKNOX1 ZMYM3 MAX ZNF175 CEBPG EBF1 RAD21 HCK PLAGL2 DUSP15 CCM2L NOL4L TM9SF4 ENSG00000226239 GC20P032051
GH20F032197 1.5 FANTOM5 ENCODE 18.6 +152.1 152115 12.7 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 TSPY26P HCK EFCAB8 PLAGL2 POFUT1 NOL4L TM9SF4 GC20P032195
GH20F032108 1.6 FANTOM5 ENCODE 13.8 +59.2 59219 5.0 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC POFUT1 REM1 PLAGL2 HCK DEFB124 ID1 TM9SF4 TSPY26P MYLK2 NOL4L
GH20F032066 1.4 FANTOM5 Ensembl ENCODE 14.7 +16.8 16813 4.4 HLF CEBPB EBF1 ZNF623 ZKSCAN1 JUND SMARCA4 POLR2A PBX2 IKZF1 HCK PLAGL2 NOL4L TM9SF4
GH20F032521 2.1 VISTA FANTOM5 Ensembl ENCODE 9.2 +473.5 473493 8.9 HDGF MLX ARID4B DMAP1 ZNF48 ZNF2 SLC30A9 ZNF143 SP5 MXD4 LOC105372591 NOL4L COMMD7 HCK MAPRE1 C20orf203 LOC149950 ENSG00000260257 PLAGL2 LOC105372592
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HCK on UCSC Golden Path with GeneCards custom track

Promoters for HCK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000399714 512 1401 CTCF MTA2 E2F1 POLR2A IKZF1 NBN KDM1A EZH2 CHD2

Genomic Location for HCK Gene

Chromosome:
20
Start:
32,052,188 bp from pter
End:
32,101,856 bp from pter
Size:
49,669 bases
Orientation:
Plus strand

Genomic View for HCK Gene

Genes around HCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCK Gene

Proteins for HCK Gene

  • Protein details for HCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08631-HCK_HUMAN
    Recommended name:
    Tyrosine-protein kinase HCK
    Protein Accession:
    P08631
    Secondary Accessions:
    • A8K1I1
    • B4DQB6
    • E1P5M2
    • Q29RX1
    • Q2VPE2
    • Q504R5
    • Q5T7K1
    • Q5T7K2
    • Q96CC0
    • Q9H5Y5
    • Q9NUA4
    • Q9UMJ5

    Protein attributes for HCK Gene

    Size:
    526 amino acids
    Molecular mass:
    59600 Da
    Quaternary structure:
    • Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with VAV1, WAS and RAPGEF1 (By similarity). Interacts (via SH3 domain) with HIV-1 Nef and Vif. This interaction stimulates its tyrosine-kinase activity. Interacts (via SH3 domain) with HEV ORF3 protein. Interacts with ARRB1 and ARRB2. Interacts with ADAM15. Interacts with FASLG. Interacts with CBL. Interacts with FCGR1A; the interaction may be indirect. Interacts with IL6ST. Interacts (via SH3 domain) with ELMO1. Interacts (via SH3 domain) with TP73. Interacts with YAP1. Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1. Interacts (via SH3 domain) with WDCP.
    SequenceCaution:
    • Sequence=AAA52643.1; Type=Frameshift; Positions=20; Evidence={ECO:0000305}; Sequence=BAF82585.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HCK Gene

    Alternative splice isoforms for HCK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HCK Gene

Selected DME Specific Peptides for HCK Gene

P08631:
  • KWTAPEA
  • DLSFQKG
  • IKSDVWSFGILL
  • FTIKSDVWSFG
  • NYIHRDLR
  • CKIADFGLAR
  • ERPTFEYIQS
  • DGLCQKLSVPC
  • RKDAERQLL
  • GQFGEVW
  • NCPEELY
  • VKHYKIR
  • GYIPSNYVA
  • KGSLLDFLK
  • GRIPYPGM
  • HRDLRAANILV
  • LETEEWFFK
  • EPIYIITE
  • KSDVWSFG
  • DFYTATE
  • KFPIKWTAPE
  • KVAVKTMK
  • AQIAEGMA
  • VLEESGEWW
  • DAWEIPR
  • LGAGQFGEV
  • PIYIITE
  • PEERPTFE

Post-translational modifications for HCK Gene

  • Isoform 2 palmitoylation at position 2 requires prior myristoylation. Palmitoylation at position 3 is required for caveolar localization of isoform 2.
  • Phosphorylated on several tyrosine residues. Autophosphorylated. Becomes rapidly phosphorylated upon activation of the immunoglobulin receptors FCGR1A and FCGR2A. Phosphorylation by the BCR-ABL fusion protein mediates activation of HCK. Phosphorylation at Tyr-411 increases kinase activity. Phosphorylation at Tyr-522 inhibits kinase activity. Kinase activity is not required for phosphorylation at Tyr-522, suggesting that this site is a target of other kinases.
  • Ubiquitinated by CBL, leading to its degradation via the proteasome.
  • Ubiquitination at Lys 28 and Lys 124
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HCK (Hck)
  • Abcam antibodies for HCK

Domains & Families for HCK Gene

Gene Families for HCK Gene

Suggested Antigen Peptide Sequences for HCK Gene

Graphical View of Domain Structure for InterPro Entry

P08631

UniProtKB/Swiss-Prot:

HCK_HUMAN :
  • The SH3 domain mediates binding to HIV-1 Nef.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Domain:
  • The SH3 domain mediates binding to HIV-1 Nef.
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with HCK: view

Function for HCK Gene

Molecular function for HCK Gene

GENATLAS Biochemistry:
hemopoietic cell kinase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Subject to autoinhibition, mediated by intramolecular interactions involving the SH2 and SH3 domains. Kinase activity is also regulated by phosphorylation at regulatory tyrosine residues. Phosphorylation at Tyr-411 is required for optimal activity. Phosphorylation at Tyr-522 inhibits kinase activity. Inhibited by PP1 and A-770041.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
UniProtKB/Swiss-Prot Induction:
Up-regulated during myeloid cell differentiation. The highest levels are detected in fully differentiated phagocytes. Up-regulated by IL2.

Enzyme Numbers (IUBMB) for HCK Gene

Gene Ontology (GO) - Molecular Function for HCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA,IMP 10092522
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA,IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 7859737
genes like me logo Genes that share ontologies with HCK: view
genes like me logo Genes that share phenotypes with HCK: view

Animal Models for HCK Gene

MGI Knock Outs for HCK:

Animal Model Products

  • Taconic Biosciences Mouse Models for HCK

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HCK Gene

Localization for HCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCK Gene

Isoform 1: Lysosome. Membrane; Lipid-anchor. Cell projection, podosome membrane; Lipid-anchor. Cytoplasm, cytosol. Note=Associated with specialized secretory lysosomes called azurophil granules. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated.
Isoform 2: Cell membrane; Lipid-anchor. Membrane, caveola; Lipid-anchor. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasmic vesicle. Lysosome. Nucleus. Note=20% of this isoform is associated with caveolae. Localization at the cell membrane and at caveolae requires palmitoylation at Cys-3. Colocalizes with the actin cytoskeleton at focal adhesions.
Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HCK gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
lysosome 5
cytoskeleton 4
golgi apparatus 3
extracellular 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for HCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005764 lysosome IEA,IDA 15998323
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with HCK: view

Pathways & Interactions for HCK Gene

genes like me logo Genes that share pathways with HCK: view

SIGNOR curated interactions for HCK Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for HCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002522 leukocyte migration involved in immune response TAS 18538446
GO:0002758 innate immune response-activating signal transduction TAS 18538446
GO:0006468 protein phosphorylation IEA,TAS 3496523
GO:0006887 exocytosis IEA --
genes like me logo Genes that share ontologies with HCK: view

Drugs & Compounds for HCK Gene

(17) Drugs for HCK Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
bosutinib Approved Pharma Target, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Bosulif Approved September 2012 Pharma 0
Adenosine triphosphate Approved Nutra 0
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Experimental Pharma Target 0
Phosphonotyrosine Experimental Pharma Target 0

(16) Additional Compounds for HCK Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for HCK Gene

Compound Action Cas Number
PP121 Dual inhibitor of tyrosine and phosphoinositide kinases 1092788-83-4
genes like me logo Genes that share compounds with HCK: view

Transcripts for HCK Gene

Unigene Clusters for HCK Gene

Hemopoietic cell kinase:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCK Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for HCK Gene

GeneLoc Exon Structure for
HCK
ECgene alternative splicing isoforms for
HCK

Expression for HCK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HCK Gene

This gene is overexpressed in Whole Blood (x39.8).

Protein differential expression in normal tissues from HIPED for HCK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.1), Monocytes (10.3), and Cervix (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HCK Gene



Protein tissue co-expression partners for HCK Gene

NURSA nuclear receptor signaling pathways regulating expression of HCK Gene:

HCK

SOURCE GeneReport for Unigene cluster for HCK Gene:

Hs.655210

mRNA Expression by UniProt/SwissProt for HCK Gene:

P08631-HCK_HUMAN
Tissue specificity: Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil.
genes like me logo Genes that share expression patterns with HCK: view

Orthologs for HCK Gene

This gene was present in the common ancestor of animals.

Orthologs for HCK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HCK 34 35
  • 97.62 (n)
dog
(Canis familiaris)
Mammalia HCK 35 34
  • 89.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HCK 34 35
  • 89.38 (n)
mouse
(Mus musculus)
Mammalia Hck 34 16 35
  • 86.7 (n)
rat
(Rattus norvegicus)
Mammalia Hck 34
  • 86.51 (n)
oppossum
(Monodelphis domestica)
Mammalia HCK 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves HCK 34 35
  • 76.1 (n)
lizard
(Anolis carolinensis)
Reptilia HCK 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hck 34
  • 65.79 (n)
zebrafish
(Danio rerio)
Actinopterygii hck 35
  • 76 (a)
OneToOne
LOC101885596 34
  • 72.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta Src64B 36
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea src-1 36
  • 43 (a)
C24G6.2a 36
  • 35 (a)
C24G6.2b 36
  • 35 (a)
F57B9.8 36
  • 32 (a)
kin-26 36
  • 32 (a)
W01B6.5 36
  • 30 (a)
F09A5.2 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
Species where no ortholog for HCK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HCK Gene

ENSEMBL:
Gene Tree for HCK (if available)
TreeFam:
Gene Tree for HCK (if available)

Paralogs for HCK Gene

Paralogs for HCK Gene

genes like me logo Genes that share paralogs with HCK: view

Variants for HCK Gene

Sequence variations from dbSNP and Humsavar for HCK Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_041709 An ovarian mucinous carcinoma sample
rs1004910 -- 32,051,627(-) TATAC(A/C)GCCGG upstream-variant-2KB
rs10557922 -- 32,059,519(+) TTTTT(-/TTT)CTTTT intron-variant
rs10599801 -- 32,089,311(+) TAATT(-/ATC)ATCCC intron-variant
rs10719271 -- 32,068,390(+) AATAA(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HCK Gene

Variant ID Type Subtype PubMed ID
nsv833953 CNV loss 17160897
nsv817891 CNV gain 17921354
nsv1109374 CNV deletion 24896259
esv3645661 CNV loss 21293372

Variation tolerance for HCK Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HCK Gene

Human Gene Mutation Database (HGMD)
HCK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCK Gene

Disorders for HCK Gene

MalaCards: The human disease database

(21) MalaCards diseases for HCK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
flying phobia
malignant anus melanoma
  • anal melanoma
pylorospasm
fourth cranial nerve palsy
  • fourth nerve palsy
- elite association - COSMIC cancer census association via MalaCards
Search HCK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HCK_HUMAN
  • Note=Aberrant activation of HCK by HIV-1 protein Nef enhances HIV-1 replication and contributes to HIV-1 pathogenicity.
  • Note=Aberrant activation of HCK, e.g. by the BCR-ABL fusion protein, promotes cancer cell proliferation.

Relevant External Links for HCK

Genetic Association Database (GAD)
HCK
Human Genome Epidemiology (HuGE) Navigator
HCK
Tumor Gene Database (TGDB):
HCK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HCK
genes like me logo Genes that share disorders with HCK: view

No data available for Genatlas for HCK Gene

Publications for HCK Gene

  1. Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis. (PMID: 18538446) Guiet R. … Maridonneau-Parini I. (Eur. J. Cell Biol. 2008) 3 4 22 64
  2. Regulation of p73 by Hck through kinase-dependent and independent mechanisms. (PMID: 17535448) Paliwal P. … Swarup G. (BMC Mol. Biol. 2007) 3 4 22 64
  3. Association of Hck genetic polymorphisms with gene expression and COPD. (PMID: 17024369) Zhang X. … Sandford A.J. (Hum. Genet. 2007) 3 22 46 64
  4. Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes. (PMID: 15998323) Cougoule C. … Maridonneau-Parini I. (Traffic 2005) 3 4 22 64
  5. Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6- induced proliferation and survival of multiple myeloma cells. (PMID: 15010462) Podar K. … Anderson K.C. (J. Biol. Chem. 2004) 3 4 22 64

Products for HCK Gene

Sources for HCK Gene

Content
Loading form....