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HCK Gene

protein-coding   GIFtS: 74
GCID: GC20P030652

Hemopoietic Cell Kinase

  See HCK-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hemopoietic Cell Kinase1 2 3     EC 2.7.10.23 8
Hematopoietic Cell Kinase2 3     JTK92
p59-HCK/p60-HCK2 3     Tyrosine-Protein Kinase HCK2
p59Hck2 3     EC 2.7.108
p61Hck2 3     

External Ids:    HGNC: 48401   Entrez Gene: 30552   Ensembl: ENSG000001013367   OMIM: 1423705   UniProtKB: P086313   

Export aliases for HCK gene to outside databases

Previous GC identifers: GC20P030428 GC20P031338 GC20P031385 GC20P030103 GC20P030641 GC20P027428 GC20P030645 GC20P030648


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HCK Gene:
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily
hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to
the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the
degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both
alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.
(provided by RefSeq, Feb 2010)

GeneCards Summary for HCK Gene:
HCK (hemopoietic cell kinase) is a protein-coding gene. Diseases associated with HCK include adenosquamous carcinoma, and cervical adenosquamous carcinoma. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is FRK.

UniProtKB/Swiss-Prot: HCK_HUMAN, P08631
Function: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell
surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil,
monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and
migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A,
but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During
the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH
oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes
reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions.
Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to
activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2,
RAPGEF1, STAT5B, TP73, VAV1 and WAS

Gene Wiki entry for HCK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the HCK gene promoter:
         p53   NF-kappaB2   STAT3   CUTL1   STAT5A   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHCK promoter sequence
   Search Chromatin IP Primers for HCK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HCK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11-q12   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11-q12

HCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCK gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P030652:  view genomic region     (about GC identifiers)

Start:
30,639,991 bp from pter      End:
30,689,659 bp from pter
Size:
49,669 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HCK_HUMAN, P08631 (See protein sequence)
Recommended Name: Tyrosine-protein kinase HCK  
Size: 526 amino acids; 59600 Da
Subunit: Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with VAV1, WAS and RAPGEF1 (By
similarity). Interacts (via SH3 domain) with HIV-1 Nef and Vif. This interaction stimulates its tyrosine-kinase
activity. Interacts (via SH3 domain) with HEV ORF3 protein. Interacts with ARRB1 and ARRB2. Interacts with
ADAM15. Interacts with FASLG. Interacts with CBL. Interacts with FCGR1A; the interaction may be indirect.
Interacts with IL6ST. Interacts (via SH3 domain) with ELMO1. Interacts (via SH3 domain) with TP73. Interacts with
YAP1. Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1
Sequence caution: Sequence=AAA52643.1; Type=Frameshift; Positions=20; Sequence=BAF82585.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for HCK (see all 27):
1AD5 (3D)        1BU1 (3D)        1QCF (3D)        2C0I (3D)        2C0O (3D)        2C0T (3D)    
Secondary accessions: A8K1I1 B4DQB6 E1P5M2 Q29RX1 Q2VPE2 Q504R5 Q5T7K1 Q5T7K2 Q96CC0 Q9H5Y5
Q9NUA4 Q9UMJ5
Alternative splicing, Alternative initiation: 4 isoforms:  P08631-1   P08631-2   P08631-3   P08631-4   (Initiates from a CTG codon)

Explore the universe of human proteins at neXtProt for HCK: NX_P08631

Explore proteomics data for HCK at MOPED

Post-translational modifications: 

  • Phosphorylated on several tyrosine residues. Autophosphorylated. Becomes rapidly phosphorylated upon activation of
    the immunoglobulin receptors FCGR1A and FCGR2A. Phosphorylation by the BCR-ABL fusion protein mediates activation
    of HCK. Phosphorylation at Tyr-411 increases kinase activity. Phosphorylation at Tyr-522 inhibits kinase
    activity. Kinase activity is not required for phosphorylation at Tyr-522, suggesting that this site is a target
    of other kinases1
  • Ubiquitinated by CBL, leading to its degradation via the proteasome1
  • Isoform 2 palmitoylation at position 2 requires prior myristoylation. Palmitoylation at position 3 is required for
    caveolar localization of isoform 21
  • Ubiquitination2 at Lys28, Lys124
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HCK (P08631) (see all 28)
     DAWEIPR  GQFGEVW  NCPEELY  KWTAPEA 


    See HCK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001165600.1  NP_001165601.1  NP_001165602.1  NP_001165603.1  NP_001165604.1  NP_002101.2  

    ENSEMBL proteins: 
     ENSP00000365022   ENSP00000420457   ENSP00000262651   ENSP00000429848   ENSP00000427757  
     ENSP00000365012   ENSP00000444986   ENSP00000441169  
    Reactome Protein details: P08631

    HCK Human Recombinant Protein Products:

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    antibodies-online peptides for HCK

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    antibodies-online antibodies for HCK (90 products) 

    HCK Assay Products:

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    Cloud-Clone Corp. ELISAs for HCK
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    antibodies-online kits for HCK (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: hemopoietic cell kinase
    Src family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P08631

    ProtoNet protein and cluster: P08631

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: HCK_HUMAN, P08631
    Domain: The SH3 domain mediates binding to HIV-1 Nef
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with HCK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HCK_HUMAN, P08631
    Function: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell
    surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil,
    monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and
    migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A,
    but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During
    the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH
    oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes
    reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions.
    Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to
    activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2,
    RAPGEF1, STAT5B, TP73, VAV1 and WAS
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Subject to autoinhibition, mediated by intramolecular interactions involving the SH2 and SH3
    domains. Kinase activity is also regulated by phosphorylation at regulatory tyrosine residues. Phosphorylation at
    Tyr-411 is required for optimal activity. Phosphorylation at Tyr-522 inhibits kinase activity. Inhibited by PP1
    and A-770041
    Induction: Up-regulated during myeloid cell differentiation. The highest levels are detected in fully
    differentiated phagocytes. Up-regulated by IL2

         Genatlas biochemistry entry for HCK:
    hemopoietic cell kinase

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity IMP10092522
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI11278465
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with HCK           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for HCK:
     Decreased substrate adherent c  Increased mitotic index  Paclitaxel antagonistic effect  Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hck):
     cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  respiratory system  skeleton  tumorigenesis 

    Find genes that share phenotypes with HCK           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hcktm1Hev for HCK

       genOway: Develop your customized and physiologically relevant rodent model for HCK

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate HCK:
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    SwitchGear 3'UTR luciferase reporter plasmidHCK 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HCK_HUMAN, P08631: Isoform 1: Lysosome. Membrane; Lipid-anchor. Cell projection, podosome membrane;
    Lipid-anchor. Cytoplasm, cytosol. Note=Associated with specialized secretory lysosomes called azurophil granules.
    At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated
    HCK_HUMAN, P08631: Isoform 2: Cell membrane; Lipid-anchor. Membrane, caveola; Lipid-anchor. Cell junction,
    focal adhesion. Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasmic vesicle. Lysosome. Nucleus. Note=20% of
    this isoform is associated with caveolae. Localization at the cell membrane and at caveolae requires
    palmitoylation at Cys-3. Colocalizes with the actin cytoskeleton at focal adhesions
    HCK_HUMAN, P08631: Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    golgi apparatus5
    lysosome5
    nucleus5
    plasma membrane5
    vacuole5
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005764lysosome IDA15998323
    GO:0005794Golgi apparatus IEA--
    GO:0005829cytosol TAS--
    GO:0005884colocalizes with actin filament IDA15998323

    Find genes that share ontologies with HCK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HCK About   (see all 34)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by Interleukins
    Interleukin-3, 5 and GM-CSF signaling0.59
    Regulation of signaling by CBL0.00
    Signaling by Interleukins0.42
    2Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
    The role of Nef in HIV-1 replication and disease pathogenesis0.76
    Nef and signal transduction0.00
    3HIV Life Cycle
    HIV Infection0.62
    Host Interactions of HIV factors0.60
    4Fcgamma receptor (FCGR) dependent phagocytosis
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    5Focal adhesion
    Focal Adhesion0.65


    Find genes that share SuperPaths with HCK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HCK
        Fc-GammaR Pathway
    Transendothelial Migration of Leukocytes
    Fc-GammaR-Mediated Phagocytosis in Macrophages

    3 Cell Signaling Technology (CST) Pathways for HCK
        MAP Kinase Signaling
    Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for HCK
        Immune response CCR3 signaling in eosinophils

    Selected BioSystems Pathways for HCK (see all 18)
        Focal Adhesion
    IL-5 Signaling Pathway
    Kit Receptor Signaling Pathway
    IL-6 Signaling Pathway
    B Cell Receptor Signaling Pathway

    3 Reactome Pathways for HCK
        Nef and signal transduction
    FCGR activation
    Regulation of signaling by CBL


    2 Kegg Pathways  (Kegg details for HCK):
        Chemokine signaling pathway
    Fc gamma R-mediated phagocytosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HCK: 
              HIV Host Response in human mouse rat
              Leukemia in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HCK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HCK (P086311, 2, 3 ENSP000003650124) via UniProtKB, MINT, STRING, and/or I2D (see all 177)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDCD6IPQ8WUM41, 2, 3, ENSP000003073874EBI-346340,EBI-310624 MINT-8109689 MINT-8374796 MINT-8374708 MINT-8374882 I2D: score=1 STRING: ENSP00000307387
    KHDRBS1Q076661, 2, 3, ENSP000003138294EBI-346340,EBI-1364 MINT-8374661 MINT-7051501 I2D: score=4 STRING: ENSP00000313829
    SOS1Q078891, 2, 3, ENSP000003846754EBI-346340,EBI-297487 MINT-7051548 I2D: score=4 STRING: ENSP00000384675
    ASAP1Q9ULH11, 2, 3, ENSP000003502974EBI-346340,EBI-346622 MINT-7145752 I2D: score=3 STRING: ENSP00000350297
    ABL1P005192, 3, ENSP000003614234MINT-7232924 MINT-7232959 MINT-7232945 MINT-18217 MINT-7232904 I2D: score=4 STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002522leukocyte migration involved in immune response TAS18538446
    GO:0002758innate immune response-activating signal transduction TAS18538446
    GO:0006468protein phosphorylation TAS3496523
    GO:0006909phagocytosis ----
    GO:0006954inflammatory response IEA--

    Find genes that share ontologies with HCK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for HCK

    2 HMDB Compounds for HCK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 DrugBank Compounds for HCK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine-- --target--17139284 17016423 10592235
    Quercetin-- 117-39-5target--17139284 17016423 10592235
    Phosphonotyrosine-- 21820-51-9target--17139284 17016423
    BosutinibBosulif® (see all 3)380843-75-4targetinhibitor--

    Selected Novoseek inferred chemical compound relationships for HCK gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 80.8 141 11106432 (5), 15752743 (3), 9642231 (3), 19234535 (3) (see all 90)
    dasatinib 66.5 2 17431118 (1), 19211505 (1)
    gp 130 53.2 10 11689697 (3), 8156996 (2), 8939963 (2), 17310994 (2)
    mdms 51.1 1 11493626 (1)
    proline 48.8 2 12525647 (1), 10364375 (1)
    imatinib 48.4 5 15039284 (2), 16953222 (1), 12764361 (1)
    phosphotyrosine 47 4 9642231 (2)
    zymosan 35.7 6 8995234 (4), 17173331 (1)
    herbimycin a 26 1 10527858 (1)
    hgcl2 21.5 5 11106432 (4)



    Find genes that share compounds with HCK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HCK gene (6 alternative transcripts): 
    NM_001172129.1  NM_001172130.1  NM_001172131.1  NM_001172132.1  NM_001172133.1  NM_002110.3  

    Unigene Cluster for HCK:

    Hemopoietic cell kinase
    Hs.655210  [show with all ESTs]
    Unigene Representative Sequence: NM_001172132
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375862 ENST00000486475 ENST00000262651 ENST00000520553 ENST00000518730
    ENST00000375852 ENST00000470092 ENST00000534862(uc010gdy.3) ENST00000538448(uc021wbv.1 uc002wxh.3 uc002wxi.3)

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    4 qRT-PCR Assays for microRNAs that regulate HCK:
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    SwitchGear 3'UTR luciferase reporter plasmidHCK 3' UTR sequence
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    Additional mRNA sequence: 

    AK026432.1 AK225819.1 AK289896.1 AK290928.1 AK298726.1 AK314335.1 BC014435.1 BC094847.1 
    BC108930.1 BC108931.1 BC113854.1 BC114463.1 

    6 DOTS entries:

    DT.311472  DT.100659852  DT.97780462  DT.444878  DT.95165612  DT.120799457 

    Selected AceView cDNA sequences (see all 82):

    AW473073 AA632353 N59457 NM_002110 AW452008 CD672014 BQ706242 CD671492 
    BC073748 BQ023841 AK026432 BP372970 AW450367 CR594271 BE670668 BF222829 
    AL543079 BE552057 CD671491 BC014435 BI905929 AI912730 BX093144 BQ062291 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HCK    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                    -     -                                                                                       
    SP2:                    -     -                                                                                       
    SP3:                    -                                                                                             
    SP4:                          -                                                                                       


    ECgene alternative splicing isoforms for HCK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HCK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGGGAGGA
    HCK Expression
    About this image


    HCK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Monocytes Peripheral Blood
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Rib
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    HCK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HCK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655210

    UniProtKB/Swiss-Prot: HCK_HUMAN, P08631
    Tissue specificity: Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of
    the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HCK gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hck1 , 5 hemopoietic cell kinase1, 5 86.7(n)1
    90.08(a)1
      2 (75.41 cM)5
    151621  NM_010407.41  NP_034537.21 
     1531084685 
    chicken
    (Gallus gallus)
    Aves HCK1 hemopoietic cell kinase 76.1(n)
    78.94(a)
      419280  XM_004947171.1  XP_004947228.1 
    lizard
    (Anolis carolinensis)
    Reptilia HCK6
    hemopoietic cell kinase
    78(a)
    1 ↔ 1
    GL343505.1(359386-396188)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hck1 hemopoietic cell kinase 65.79(n)
    67.81(a)
      548439  NM_001015722.1  NP_001015722.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018855961 tyrosine-protein kinase HCK-like 72.57(n)
    77.26(a)
      101885596  XM_005174121.1  XP_005174178.1 


    ENSEMBL Gene Tree for HCK (if available)
    TreeFam Gene Tree for HCK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HCK gene
    FRK2  LCK2  BLK2  LYN2  FGR2  PTK62  YES12  ABL12  
    SRC2  FYN2  ABL22  SRMS2  
    Selected SIMAP similar genes for HCK using alignment to 6 protein entries:     HCK_HUMAN (see all proteins) (see all similar genes):
    BLK    LYN    FYN    YES1    SRC    FGR
    NCK2    EPHA2    FRK    GRAP2    tec    LCK
    ABL1    EPHA6    MET    EPHA3    PTK6    ZAK

    Find genes that share paralogs with HCK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HCK (see all 1212)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0417094
    An ovarian mucinous carcinoma sample4--see VAR_0417092 D G mis40--------
    rs2008596541,2
    C--27429255(+) GGGGG-/GGCGGGGA 6 -- int10--------
    rs589763421,2
    C--27429256(+) GGGGG-/C/GC  
            
    GGGGa
    6 -- int10--------
    rs717085511,2
    C--27429256(+) GGGGG-/GCGGGGA 6 -- int10--------
    rs60611341,2
    C--27429257(+) GGGGGG/CGGGGa 6 -- int11Minor allele frequency- C:0.50WA 2
    rs114803221,2
    C--27478599(+) AAAAA-/AGATGA 6 -- ds50010--------
    rs345073581,2
    C--30641801(+) TTTTT-/TAGGGG 6 -- int10--------
    rs38333161,2
    C--30646034(+) AATCC-/AAAAAA 6 -- int1 trp32Minor allele frequency- A:0.00NA CSA 4
    rs607409931,2
    C--30646413(+) ACACACACACA/-
            
    TACAC
    6 -- cds11Minor allele frequency- -:0.00NA 2
    rs61213291,2
    A--30647212(+) cttctC/Ttctct 6 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for HCK (30639991 - 30689659 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HCK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833953CNV Loss17160897
    nsv817891CNV Gain17921354

    Human Gene Mutation Database (HGMD): HCK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HCK
    DNA2.0 Custom Variant and Variant Library Synthesis for HCK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142370    OMIM disorders: --

    UniProtKB/Swiss-Prot: HCK_HUMAN, P08631
  • Note=Aberrant activation of HCK by HIV-1 protein Nef enhances HIV-1 replication and contributes to HIV-1
    pathogenicity
  • Note=Aberrant activation of HCK, e.g. by the BCR-ABL fusion protein, promotes cancer cell proliferation

  • 3 diseases for HCK:    
    About MalaCards
    adenosquamous carcinoma    cervical adenosquamous carcinoma    parkinson's disease

    2 diseases from the University of Copenhagen DISEASES database for HCK:
    Cervical adenosquamous carcinoma     Acquired immunodeficiency syndrome

    Find genes that share disorders with HCK           About GenesLikeMe

    9 Novoseek inferred disease relationships for HCK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 54.7 3 17344919 (1), 16546576 (1), 9390404 (1)
    immunodeficiency 36.1 13 10473622 (2), 9621101 (2), 9218412 (1), 15613341 (1) (see all 7)
    myeloid leukemia 25.2 1 10849448 (1)
    aids 21.4 4 17893228 (1), 15595833 (1), 16352531 (1), 17920628 (1)
    leukemia 18.3 3 17344919 (2), 18538446 (1)
    lymphoblastic leukemia acute 15.1 8 10720701 (2), 10658677 (2), 17344919 (1)
    cancer 4.85 1 7690925 (1)
    tumors 3.42 3 17344919 (1), 19211505 (1), 12237848 (1)
    necrosis 0 1 12237848 (1)

    Genetic Association Database (GAD): HCK
    Human Genome Epidemiology (HuGE) Navigator: HCK (6 documents)
    Tumor Gene Database (TGDB): HCK

    Export disorders for HCK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HCK gene, integrated from 10 sources (see all 326):
    (articles sorted by number of sources associating them with HCK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. (PubMed id 3496523)1, 2, 3 Quintrell N.... Rowley J.D. (Mol. Cell. Biol. 1987)
    2. Regulation of p73 by Hck through kinase-dependent and independent mechanisms. (PubMed id 17535448)1, 2, 9 Paliwal P.... Swarup G. (BMC Mol. Biol. 2007)
    3. Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis. (PubMed id 18538446)1, 2, 9 Guiet R.... Maridonneau-Parini I. (Eur. J. Cell Biol. 2008)
    4. Association of Hck genetic polymorphisms with gene expression and COPD. (PubMed id 17024369)1, 4, 9 Zhang X....Sandford A.J. (Hum. Genet. 2007)
    5. The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein. (PubMed id 11278465)1, 2, 9 Hassaine G.... Decroly E. (J. Biol. Chem. 2001)
    6. The Src family kinase Hck interacts with Bcr-Abl by a kinase- independent mechanism and phosphorylates the Grb2-binding site of Bcr. (PubMed id 9407116)1, 2, 9 Warmuth M....Hallek M. (J. Biol. Chem. 1997)
    7. SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1. (PubMed id 9218412)1, 2, 9 Briggs S.D.... Smithgall T.E. (J. Biol. Chem. 1997)
    8. Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. (PubMed id 11741929)1, 2, 9 Poghosyan Z....Edwards D.R. (J. Biol. Chem. 2002)
    9. Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization. (PubMed id 1875927)1, 2, 9 Lock P.... Dunn A.R. (Mol. Cell. Biol. 1991)
    10. Solution structure of the human Hck SH3 domain and identification of its ligand binding site. (PubMed id 9571048)1, 2, 9 Horita D.A.... Byrd R.A. (J. Mol. Biol. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3055 HGNC: 4840 AceView: HCK Ensembl:ENSG00000101336 euGenes: HUgn3055
    ECgene: HCK Kegg: 3055 H-InvDB: HCK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HCK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HCK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HCK gene:
    Search GeneIP for patents involving HCK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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