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HLA complex group 22 (non-protein coding)(Previous name: HLA complex group 22 )
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Aliases
for HCG22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): processed_transcript
Quality score for this RNA gene is 3
| Aliases |
|---|
| HLA Complex Group 22 (Non-Protein Coding)1 2 | | PBMUCL21 2 3 | | HLA Complex Group 221 3 | | FLJ371141 | | G23 | | Panbronchiolitis-Related Mucin-Like Protein 23 |
Export aliases for HCG22 gene to outside databasesPrevious GC identifers: GC06U900708 GC06P031129 GC06Pf31157 |
Summaries
for HCG22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HCG22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1
- NT_167248.1 NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HCG22 gene promoter:
COUP-TF1 COUP HNF-4alpha2 HNF-4alpha1 PPAR-gamma1 COUP-TF Zic1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HCG22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCG22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.33 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.32HCG22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P031022: view genomic region
(about GC identifiers)
Start:
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31,021,227 bp from pter |
End:
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31,027,667 bp from pter |
Size:
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6,441 bases |
Orientation:
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plus strand |
6/7 alternative locations (see all 7):
| Chr6+,ALT_REF_LOCI_5 31,015,340-31,021,000 | Chr6+,ALT_REF_LOCI_2 31,014,486-31,059,344 | Chr6+,ALT_REF_LOCI_3 31,015,766-31,032,474 | | Chr6+,ALT_REF_LOCI_4 30,989,998-30,995,662 | Chr6+,ALT_REF_LOCI_6 31,014,738-31,055,619 | Chr6+,ALT_REF_LOCI_1 31,033,296-31,047,266 | |
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Proteins
for HCG22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PBMU2_HUMAN, E2RYF7 (See
protein sequence)Recommended Name: Protein PBMUCL2 precursor Size: 251 amino acids; 26282 Da
Subcellular location: Secreted (Potential)Explore the universe of human proteins at neXtProt for HCG22: NX_E2RYF7
HCG22 Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
HCG22 for ontologies About GeneDecksing
HCG22 Antibody Products:
Assay Products for HCG22: |
Protein
Domains /
Families
for HCG22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: E2RYF7 |
Function
for HCG22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCG22 |
|
Pathways & Interactions
for HCG22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HCG22
|
Drugs & Compounds
for HCG22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HCG22
Search CenterWatch for drugs/clinical trials and news about HCG22 
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Transcripts
for HCG22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for HCG22: HLA complex group 22 (non-protein coding) Hs.207528 [show with all ESTs]Unigene Representative Sequence: NR_0039485 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000565192(lincRNA)(uc021yui.1) ENST00000562344(lincRNA) ENST00000570223(lincRNA) ENST00000566475(lincRNA)
ENST00000426185(lincRNA)(uc003nsj.2)
Additional cDNA sequence: AB560771.1 AB600644.1 AK094433.1 NR_003948.2 1 DOTS entry: DT.99999057 3 AceView cDNA sequences: BM453661 AI804667 AK094433
GeneLoc Exon Structure
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Expression
for HCG22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for HCG22:none
HCG22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAGGACAC
About this image
Genevestigator expression for HCG22
SOURCE GeneReport for Unigene cluster: Hs.207528
UniProtKB/Swiss-Prot: PBMU2_HUMAN, E2RYF7Tissue specificity: Detected in the brain, lung, spleen, thymus and prostate
SABiosciences Custom PCR Arrays for HCG22
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HCG22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HCG22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HCG22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HCG22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCG22 |
Orthologs
for HCG22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for HCG22 (if available)
TreeFam Gene Tree for HCG22 (if available) |
Paralogs
for HCG22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HCG22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HCG22 (31021227 - 31027667 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for HCG22
7 Indels: 81306 93602 40849 64465 81307 42406 93601 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for HCG22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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HCG22 for disorders About GeneDecksing
OMIM gene information: 613918
OMIM disorders: --
5  diseases for HCG22: About MalaCardsdiffuse panbronchiolitis panbronchiolitis systemic lupus erythematosus lupus erythematosus
prostatitis
Human Genome Epidemiology (HuGE) Navigator: HCG22 (2 documents)
Export disorders for HCG22 gene to outside databases
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Publications
for HCG22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HCG22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HCG22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of two novel mucin-like genes in th e disease-susceptibility locus for diffuse panbronchiolitis. (PubMed id 20981447)1, 2 Hijikata M....Keicho N. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (2004)
- Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)1 Eriksson N....Do C.B. (2012)
- The major genetic determinants of HIV-1 control affec t HLA class I peptide presentation. (PubMed id 21051598)1 ....Zhao M. (2010)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
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External Searches for HCG22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing HCG22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing HCG22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HCG22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HCG22 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for HCG22 gene:
Search GeneIP for patents involving HCG22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HCG22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HCG22 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HCG22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCG22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HCG22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HCG22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HCG22 |
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| | | | Search Tocris compounds for HCG22 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCG22 |
|  |  |  | | | | Search ThermoFisher Antibodies for HCG22 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HCG22 |
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