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Aliases for HCG22 Gene

Aliases for HCG22 Gene

  • HLA Complex Group 22 (Gene/Pseudogene) 2 3 5
  • Panbronchiolitis-Related Mucin-Like Protein 2 3 4
  • HLA Complex Group 22 (Non-Protein Coding) 2 3
  • Panbronchiolitis Related Mucin-Like 2 2 3
  • HLA Complex Group 22 2 4
  • PBMUCL2 3 4
  • Protein PBMUCL2 3
  • G2 4

External Ids for HCG22 Gene

Previous GeneCards Identifiers for HCG22 Gene

  • GC06U900708
  • GC06P031129
  • GC06Pf31157
  • GC06P031022

Summaries for HCG22 Gene

GeneCards Summary for HCG22 Gene

HCG22 (HLA Complex Group 22 (Gene/Pseudogene)) is a Protein Coding gene.

Additional gene information for HCG22 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCG22 Gene

Genomics for HCG22 Gene

GeneHancer (GH) Regulatory Elements for HCG22 Gene

Promoters and enhancers for HCG22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I031113 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 25.7 +61.5 61457 2.5 FEZF1 RAD21 ZNF335 GLIS2 FOS EGR2 ZNF398 REST ZNF217 SP1 PSORS1C1 HCG22 MICB ENSG00000272501 POU5F1 HLA-C TRIM10 TCF19 CDSN
GH06I031086 Enhancer 1.1 Ensembl ENCODE 31.9 +33.7 33706 1.7 PKNOX1 TCF12 ZNF121 ZNF143 FOS ATF7 KDM4B KLF13 JUNB REST GC06P031966 HCG22 TRIM39 DHX16 DDX39B PPP1R10 LY6G5B SKIV2L BAG6 MDC1
GH06I031352 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13 +302.7 302742 7 HDGF PKNOX1 ATF1 SMAD1 NSD2 ZNF2 IRF4 GLIS2 ZNF207 ZNF143 HLA-B ENSG00000271581 GC06M031409 GC06M031410 PIR40863 MIR6891 HLA-C DDX39B MICA LY6G5B
GH06I031056 Enhancer 1 Ensembl ENCODE 29.3 +4.5 4515 2.1 INSM2 KLF17 BATF RAD21 RFX5 ZNF366 RCOR1 FOS SMARCC1 USF2 GC06P031584 HCG22 HLA-C PSORS1C1 PSORS1C3 MICB RNU6-1133P
GH06I031083 Enhancer 1.1 Ensembl ENCODE 26 +30.5 30539 0.9 PKNOX1 SMAD1 ATF1 ARNT GTF3C2 ZNF143 ATF7 REST ATF4 SMARCA4 GC06P031966 RNU6-1133P HCG22 HLA-C PRRC2A PSORS1C1 MDC1 HCG18 TRIM39 PSORS1C2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HCG22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HCG22 gene promoter:

Genomic Locations for HCG22 Gene

Genomic Locations for HCG22 Gene
chr6:31,053,450-31,059,890
(GRCh38/hg38)
Size:
6,441 bases
Orientation:
Plus strand
chr6:31,021,227-31,027,667
(GRCh37/hg19)

Genomic View for HCG22 Gene

Genes around HCG22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCG22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCG22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HCG22 Gene

  • Protein details for HCG22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E2RYF7-PBMU2_HUMAN
    Recommended name:
    Protein PBMUCL2
    Protein Accession:
    E2RYF7

    Protein attributes for HCG22 Gene

    Size:
    251 amino acids
    Molecular mass:
    26282 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HCG22 Gene

Post-translational modifications for HCG22 Gene

Other Protein References for HCG22 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for HCG22 Gene

Domains & Families for HCG22 Gene

Protein Domains for HCG22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HCG22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HCG22: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HCG22 Gene

Function for HCG22 Gene

Phenotypes From GWAS Catalog for HCG22 Gene

Phenotypes for HCG22 Gene

genes like me logo Genes that share phenotypes with HCG22: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HCG22 Gene

Localization for HCG22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCG22 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for HCG22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with HCG22: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HCG22 Gene

Pathways & Interactions for HCG22 Gene

SuperPathways for HCG22 Gene

No Data Available

Interacting Proteins for HCG22 Gene

Gene Ontology (GO) - Biological Process for HCG22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HCG22 Gene

Drugs & Compounds for HCG22 Gene

(1) Drugs for HCG22 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Triamcinolone Approved, Vet_approved Pharma Agonist 565
genes like me logo Genes that share compounds with HCG22: view

Transcripts for HCG22 Gene

mRNA/cDNA for HCG22 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HCG22 Gene

HLA complex group 22 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HCG22 Gene

No ASD Table

Relevant External Links for HCG22 Gene

GeneLoc Exon Structure for
HCG22
ECgene alternative splicing isoforms for
HCG22

Expression for HCG22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HCG22 Gene

mRNA differential expression in normal tissues according to GTEx for HCG22 Gene

This gene is overexpressed in Vagina (x20.5), Esophagus - Mucosa (x11.7), Cervix - Ectocervix (x8.2), and Minor Salivary Gland (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of HCG22 Gene:

HCG22

SOURCE GeneReport for Unigene cluster for HCG22 Gene:

Hs.207528

mRNA Expression by UniProt/SwissProt for HCG22 Gene:

E2RYF7-PBMU2_HUMAN
Tissue specificity: Detected in the brain, lung, spleen, thymus and prostate.
genes like me logo Genes that share expression patterns with HCG22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HCG22 Gene

Orthologs for HCG22 Gene

Evolution for HCG22 Gene

ENSEMBL:
Gene Tree for HCG22 (if available)
TreeFam:
Gene Tree for HCG22 (if available)

No data available for Orthologs for HCG22 Gene

Paralogs for HCG22 Gene

No data available for Paralogs for HCG22 Gene

Variants for HCG22 Gene

Sequence variations from dbSNP and Humsavar for HCG22 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000808766 -- 31,060,028(+) G/A downstream_transcript_variant
rs1001108260 -- 31,054,812(+) T/A intron_variant
rs1001200872 -- 31,058,967(+) A/G intron_variant
rs1002757659 -- 31,053,058(+) T/C upstream_transcript_variant
rs1002833744 -- 31,059,436(+) C/T non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HCG22 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv2731805 CNV deletion 23290073
esv2731808 CNV deletion 23290073
esv2731809 CNV deletion 23290073
esv27565 CNV loss 19812545
esv3411275 CNV duplication 20981092
esv3567519 CNV deletion 23714750
esv3608524 CNV loss 21293372
esv4161 CNV loss 18987735
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv511865 CNV loss 21212237
nsv524716 CNV loss 19592680
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv601488 CNV loss 21841781

Additional Variant Information for HCG22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HCG22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HCG22 Gene

Disorders for HCG22 Gene

Additional Disease Information for HCG22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HCG22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HCG22 Gene

Publications for HCG22 Gene

  1. Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension. (PMID: 25813999) Jeong S … Fini ME (Investigative ophthalmology & visual science 2015) 2 3 58
  2. Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis. (PMID: 20981447) Hijikata M … Keicho N (Human genetics 2011) 3 4 58
  3. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. (PMID: 21051598) International HIV Controllers Study … Zhao M (Science (New York, N.Y.) 2010) 3 44 58
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 58

Products for HCG22 Gene

Sources for HCG22 Gene

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