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Aliases & Descriptions for HCFC2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ94012 2 | | HCF-2 1, 2, 3 | | HCF2 2, 5 |
| | | Descriptions |
|---|
| C2 factor 3 | | host cell factor 2 2 | | host cell factor C2 2 |
|
| | Search outside databases for aliases for HCFC2 genePrevious GC identifer: GC12P102961 |
Summaries for HCFC2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HCFC2: This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq]
|
Genomic Location for HCFC2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HCFC2 gene 
Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q23.3HCFC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P102962:
(about GC identifiers)
Start:
|
102,982,439 bp from pter |
End:
|
103,021,373 bp from pter |
Size:
|
38,935 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_019546.15
| Proteins for HCFC2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HCFC2_HUMAN, Q9Y5Z7 (See
protein sequence)Recommended Name: Host cell factor 2 Size: 792 amino acids; 86779 Da
Subunit: Binds MLL. Component of the MLL complex, at least composed of MLL, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2
Subcellular location: Cytoplasm. NucleusPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_037452.1
ENSEMBL proteins: ENSP00000229330 ENSP00000376604
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: HCFC2 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HCFC2: Assays for HCFC2: | Protein
Domains/ Families for HCFC2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y5Z7
ProtoNet protein and cluster: Q9Y5Z7 1 Blocks protein family: IPB000515 Binding-protein-dependent transport systems inner membrane component
UniProtKB/Swiss-Prot: HCFC2_HUMAN, Q9Y5Z7Similarity: Contains 3 fibronectin type-III domainsSimilarity: Contains 4 Kelch repeats | Gene Function for HCFC2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013320
Applied Biosystems Silencer® siRNAs for HCFC2
Sigma-Aldrich siRNA for HCFC2  Sigma-Aldrich shRNA for HCFC2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_013320                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_013320                                  untagged cDNA clone in CMV expression vector: NM_013320 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_013320
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for HCFC2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for HCFC2 (ENSP000002293303) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for HCFC2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for HCFC2
|
Transcripts for HCFC2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013320
Sigma-Aldrich siRNA for HCFC2  Sigma-Aldrich shRNA for HCFC2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_013320 REFSEQ mRNAs for HCFC2 gene: NM_013320.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_013320               OriGene GFP tagged cDNA clone in CMV expression vector: NM_013320                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_013320                                  untagged cDNA clone in CMV expression vector: NM_013320  Additional cDNA sequence: AF117210.1 AK223342.1 AK296523.1 AK313466.1 BC033799.1 7 DOTS entries: DT.213417 DT.409633 DT.100779817 DT.95375371 DT.121164082 DT.91886501 DT.40125488 24/91 AceView cDNA sequences (see all 91
):AA382777 NM_013320 AA844108 AA298808 CA450011 AL138197 CB129324 BU689523 AF117210 AA421368 AU185964 CB136198 BX484383 AI972100 CA432700 BX116970 BC033799 AI670821 AL601403 AA303058 AA600253 CA430675 BM672018 BP369059
highest scoring ESTs for HCFC2:AA789205 AA278680 AA278688 AA292636 AA292637 AA298808 AA421286 AA600253 AA608906 AA625767 Unigene Cluster for HCFC2: Host cell factor C2 Hs.506558 [show with all ESTs]Unigene Representative Sequence: NM_013320
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HCFC2 (see all 6
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | · | 17d | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for HCFC2
2 Ensembl transcripts including schematic representations: ENST00000229330
ENST00000392864
|
Expression for HCFC2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HCFC2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HCFC2
1 / 2 / 3 7 probe-sets matching HCFC2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TATGAAGGAC
SOURCE GeneReport for Unigene cluster: Hs.506558 UniProtKB/Swiss-Prot: HCFC2_HUMAN, Q9Y5Z7Tissue specificity: Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon |
Orthologs for HCFC2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HCFC2 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for HCFC2
ENSEMBL Gene Tree for HCFC2 | Paralogs for HCFC2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for HCFC2 gene
- HCFC12 KLHDC102 RABEPK2
|
SNPs/Variants for HCFC2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HCFC2 (up to first 250kb)
|
Disorders & Mutations for HCFC2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607926
|
Medical News for HCFC2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HCFC2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for HCFC2 gene (see all 12
): |
Search for HCFC2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HCFC2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HCFC2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HCFC2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HCFC2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HCFC2:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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