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Aliases for HCFC2 Gene

Aliases for HCFC2 Gene

  • Host Cell Factor C2 2 3 5
  • C2 Factor 3 4
  • HCF-2 3 4
  • Host Cell Factor 2 3
  • HCF2 3

External Ids for HCFC2 Gene

Previous GeneCards Identifiers for HCFC2 Gene

  • GC12P102961
  • GC12P102962
  • GC12P104458
  • GC12P101517

Summaries for HCFC2 Gene

Entrez Gene Summary for HCFC2 Gene

  • This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HCFC2 Gene

HCFC2 (Host Cell Factor C2) is a Protein Coding gene. Diseases associated with HCFC2 include Herpes Simplex. Among its related pathways are Influenza A. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is HCFC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCFC2 Gene

Genomics for HCFC2 Gene

Regulatory Elements for HCFC2 Gene

Enhancers for HCFC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F103955 1.2 ENCODE 12 -107.5 -107511 2.6 HDGF ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 GLT8D2 C12orf73 MIR3652 HSP90B1 TTC41P HCFC2 TDG GC12P103942
GH12F103927 1.2 ENCODE 12 -134.1 -134110 6.4 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 GLT8D2 HCFC2 TTC41P C12orf73 NT5DC3 ENSG00000257681 GC12P103932 GC12P103934
GH12F104350 0.8 ENCODE 9.7 +286.7 286686 0.7 ZFP64 ZNF140 ZNF266 CHD7 ZNF101 POLR2A ZNF138 CBX5 ZNF433 ZNF202 WASHC4 HCFC2 C12orf73 GC12P104350 PIR31122 GC12P104371
GH12F104476 1.6 FANTOM5 Ensembl ENCODE 1.2 +415.1 415144 6.0 HDGF PKNOX1 WRNIP1 ELK1 GATA2 CBX5 ZNF207 JUNB TBX21 CREB3 CHST11 EID3 HCFC2 GC12P104468 GC12P104505
GH12F104063 1.1 ENCODE 0.8 +0.2 152 2.8 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 NFYB C12orf73 GC12M104050 HCFC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HCFC2 on UCSC Golden Path with GeneCards custom track

Promoters for HCFC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090579 343 2801 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for HCFC2 Gene

Chromosome:
12
Start:
104,064,457 bp from pter
End:
104,106,525 bp from pter
Size:
42,069 bases
Orientation:
Plus strand

Genomic View for HCFC2 Gene

Genes around HCFC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCFC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCFC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCFC2 Gene

Proteins for HCFC2 Gene

  • Protein details for HCFC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Z7-HCFC2_HUMAN
    Recommended name:
    Host cell factor 2
    Protein Accession:
    Q9Y5Z7
    Secondary Accessions:
    • B2R8Q5
    • C0H5X3

    Protein attributes for HCFC2 Gene

    Size:
    792 amino acids
    Molecular mass:
    86779 Da
    Quaternary structure:
    • Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2.

    Alternative splice isoforms for HCFC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HCFC2 Gene

Post-translational modifications for HCFC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HCFC2 Gene

No data available for DME Specific Peptides for HCFC2 Gene

Domains & Families for HCFC2 Gene

Suggested Antigen Peptide Sequences for HCFC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Z7

UniProtKB/Swiss-Prot:

HCFC2_HUMAN :
  • Contains 3 fibronectin type-III domains.
  • Contains 4 Kelch repeats.
Domain:
  • Contains 3 fibronectin type-III domains.
Similarity:
  • Contains 4 Kelch repeats.
genes like me logo Genes that share domains with HCFC2: view

No data available for Gene Families for HCFC2 Gene

Function for HCFC2 Gene

Gene Ontology (GO) - Molecular Function for HCFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 10196288
genes like me logo Genes that share ontologies with HCFC2: view
genes like me logo Genes that share phenotypes with HCFC2: view

Animal Model Products

miRNA for HCFC2 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HCFC2 Gene

Localization for HCFC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCFC2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HCFC2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for HCFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10196288
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 10196288
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with HCFC2: view

Pathways & Interactions for HCFC2 Gene

SuperPathways for HCFC2 Gene

SuperPathway Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with HCFC2: view

Pathways by source for HCFC2 Gene

1 KEGG pathway for HCFC2 Gene

Gene Ontology (GO) - Biological Process for HCFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10196288
GO:0016032 viral process TAS 10196288
genes like me logo Genes that share ontologies with HCFC2: view

No data available for SIGNOR curated interactions for HCFC2 Gene

Transcripts for HCFC2 Gene

Unigene Clusters for HCFC2 Gene

Host cell factor C2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCFC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5:
SP6:

Relevant External Links for HCFC2 Gene

GeneLoc Exon Structure for
HCFC2
ECgene alternative splicing isoforms for
HCFC2

Expression for HCFC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HCFC2 Gene

Protein differential expression in normal tissues from HIPED for HCFC2 Gene

This gene is overexpressed in Heart (36.2) and Testis (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HCFC2 Gene



Protein tissue co-expression partners for HCFC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HCFC2 Gene:

HCFC2

SOURCE GeneReport for Unigene cluster for HCFC2 Gene:

Hs.506558

mRNA Expression by UniProt/SwissProt for HCFC2 Gene:

Q9Y5Z7-HCFC2_HUMAN
Tissue specificity: Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon.
genes like me logo Genes that share expression patterns with HCFC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HCFC2 Gene

Orthologs for HCFC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HCFC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HCFC2 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia HCFC2 34 35
  • 94.53 (n)
dog
(Canis familiaris)
Mammalia HCFC2 34 35
  • 94.18 (n)
rat
(Rattus norvegicus)
Mammalia Hcfc2 34
  • 86.46 (n)
mouse
(Mus musculus)
Mammalia Hcfc2 34 16 35
  • 86.03 (n)
oppossum
(Monodelphis domestica)
Mammalia HCFC2 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HCFC2 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves HCFC2 34 35
  • 74.96 (n)
lizard
(Anolis carolinensis)
Reptilia HCFC2 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hcfc2 34
  • 73.05 (n)
Str.17237 34
zebrafish
(Danio rerio)
Actinopterygii hcfc2 35
  • 53 (a)
OneToOne
Dr.18404 34
Species where no ortholog for HCFC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HCFC2 Gene

ENSEMBL:
Gene Tree for HCFC2 (if available)
TreeFam:
Gene Tree for HCFC2 (if available)

Paralogs for HCFC2 Gene

Paralogs for HCFC2 Gene

(1) SIMAP similar genes for HCFC2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for HCFC2 Gene

genes like me logo Genes that share paralogs with HCFC2: view

Variants for HCFC2 Gene

Sequence variations from dbSNP and Humsavar for HCFC2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10129058 -- 104,078,855(+) tgcct(C/T)aactg intron-variant
rs10548495 -- 104,087,411(+) AGTAC(-/GTGT)GTGTG intron-variant
rs10548496 -- 104,087,483(+) TATAT(-/AT)GTATA intron-variant
rs10861156 -- 104,088,463(+) TTACT(A/G)TGTAT intron-variant
rs10861157 -- 104,096,929(+) TAGGA(A/G)CACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HCFC2 Gene

Variant ID Type Subtype PubMed ID
esv2746313 CNV deletion 23290073
esv2746314 CNV deletion 23290073

Variation tolerance for HCFC2 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HCFC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HCFC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCFC2 Gene

Disorders for HCFC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HCFC2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
- elite association - COSMIC cancer census association via MalaCards
Search HCFC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HCFC2

Genetic Association Database (GAD)
HCFC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HCFC2
genes like me logo Genes that share disorders with HCFC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HCFC2 Gene

Publications for HCFC2 Gene

  1. Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2. (PMID: 10196288) Johnson K.M. … Wilson A.C. (J. Virol. 1999) 2 3 4 64
  2. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. (PMID: 15199122) Yokoyama A. … Cleary M.L. (Mol. Cell. Biol. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for HCFC2 Gene

Sources for HCFC2 Gene

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