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HCFC2 Gene

protein-coding   GIFtS: 54
GCID: GC12P104458

Host Cell Factor C2

  See HCFC2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Host Cell Factor C21 2
HCF-22 3
C2 Factor2 3
HCF22 5
Host Cell Factor 22

External Ids:    HGNC: 249721   Entrez Gene: 299152   Ensembl: ENSG000001117277   OMIM: 6079265   UniProtKB: Q9Y5Z73   

Export aliases for HCFC2 gene to outside databases

Previous GC identifers: GC12P102961 GC12P102962 GC12P101517


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HCFC2 Gene:
This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates
virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a
beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection
while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have
been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for HCFC2 Gene:
HCFC2 (host cell factor C2) is a protein-coding gene. Diseases associated with HCFC2 include botulism, and herpes simplex. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is KLHDC2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HCFC2 gene promoter:
         Sp1   Pbx1a   Olf-1   AP-4   POU3F2   POU2F1   FOXJ2 (long isoform)   POU2F1a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHCFC2 promoter sequence
   Search Chromatin IP Primers for HCFC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HCFC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

HCFC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCFC2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P104458:  view genomic region     (about GC identifiers)

Start:
104,458,235 bp from pter      End:
104,500,302 bp from pter
Size:
42,068 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HCFC2_HUMAN, Q9Y5Z7 (See protein sequence)
Recommended Name: Host cell factor 2  
Size: 792 amino acids; 86779 Da
Subunit: Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5,
DPY30, WDR5, MEN1, HCFC1 and HCFC2
Secondary accessions: B2R8Q5

Explore the universe of human proteins at neXtProt for HCFC2: NX_Q9Y5Z7

Explore proteomics data for HCFC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HCFC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037452.1  
    ENSEMBL proteins: 
     ENSP00000229330   ENSP00000442942   ENSP00000447952  

    HCFC2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HCFC2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011043 Gal_Oxase/kelch_b-propeller
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR015916 Gal_Oxidase_b-propeller
     IPR015915 Kelch-typ_b-propeller

    Graphical View of Domain Structure for InterPro Entry Q9Y5Z7

    ProtoNet protein and cluster: Q9Y5Z7

    1 Blocks protein domain: IPB000515 Binding-protein-dependent transport systems inner membrane component

    UniProtKB/Swiss-Prot: HCFC2_HUMAN, Q9Y5Z7
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 4 Kelch repeats


    Find genes that share domains with HCFC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS10196288
    GO:0005515protein binding ----
         
    Find genes that share ontologies with HCFC2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HCFC2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HCFC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HCFC2

    miRNA
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    Block miRNA regulation of human, mouse, rat HCFC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HCFC2 (see all 80):
    hsa-miR-520e hsa-miR-485-3p hsa-miR-605 hsa-miR-30d hsa-miR-3653 hsa-miR-30a hsa-miR-642b hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidHCFC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HCFC2
    Predesigned siRNA for gene silencing in human, mouse, rat HCFC2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: HCFC2 (NM_013320)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HCFC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCFC2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCFC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HCFC2_HUMAN, Q9Y5Z7: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion2
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with HCFC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HCFC2 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Herpes simplex infection0.33


    Find genes that share SuperPaths with HCFC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for HCFC2):
        Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HCFC2
    Interactions:

        Search GeneGlobe Interaction Network for HCFC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HCFC2 (Q9Y5Z73 ENSP000002293304) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBBP5Q152913, ENSP000002645154I2D: score=2 STRING: ENSP00000264515
    ASH2LQ9UBL33, ENSP000003408964I2D: score=1 STRING: ENSP00000340896
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    HCFC1P516103, ENSP000003095554I2D: score=1 STRING: ENSP00000309555
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10196288
    GO:0016032viral process TAS10196288

    Find genes that share ontologies with HCFC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HCFC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HCFC2 gene: 
    NM_013320.2  

    Unigene Cluster for HCFC2:

    Host cell factor C2
    Hs.506558  [show with all ESTs]
    Unigene Representative Sequence: NM_013320
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229330(uc001tkj.4 uc009zul.3) ENST00000544223 ENST00000550444
    ENST00000547194 ENST00000550335 ENST00000552343
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HCFC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HCFC2 (see all 80):
    hsa-miR-520e hsa-miR-485-3p hsa-miR-605 hsa-miR-30d hsa-miR-3653 hsa-miR-30a hsa-miR-642b hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidHCFC2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HCFC2
    Predesigned siRNA for gene silencing in human, mouse, rat HCFC2
    Clone
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    OriGene ORF clones in mouse, rat for HCFC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HCFC2 (NM_013320)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HCFC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCFC2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HCFC2
    OriGene qSTAR qPCR primer pairs in human, mouse for HCFC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HCFC2
      QuantiTect SYBR Green Assays in human, mouse, rat HCFC2
      QuantiFast Probe-based Assays in human, mouse, rat HCFC2

    Additional mRNA sequence: 

    AF117210.1 AK223342.1 AK296523.1 AK313466.1 BC033799.1 

    8 DOTS entries:

    DT.213417  DT.409633  DT.100779817  DT.95375371  DT.121164082  DT.91886501  DT.100770601  DT.40125488 

    Selected AceView cDNA sequences (see all 91):

    AL601403 AA303058 BX116970 BM672018 CB129324 BC033799 AU185964 BF063207 
    AA298808 CB136198 CA450011 AA917528 BU689523 AA600253 AA806783 CA430675 
    BX484383 BC006558 AL138197 AA278680 AF117210 AI972100 NM_013320 AA421368 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HCFC2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
    SP1:              -                                                                       -     -                                       
    SP2:              -                                               -                       -     -                                       
    SP3:                                                                                      -     -           -                           
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for HCFC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HCFC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGAAGGAC
    HCFC2 Expression
    About this image

    HCFC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HCFC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506558

    UniProtKB/Swiss-Prot: HCFC2_HUMAN, Q9Y5Z7
    Tissue specificity: Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small
    intestine and colon

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCFC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HCFC2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hcfc21 , 5 host cell factor C21, 5 86.03(n)1
    88.55(a)1
      10 (39.93 cM)5
    679331  NM_001081218.11  NP_001074687.11 
     826961605 
    chicken
    (Gallus gallus)
    Aves HCFC21 host cell factor C2 74.96(n)
    75.81(a)
      418083  XM_004937828.1  XP_004937885.1 
    lizard
    (Anolis carolinensis)
    Reptilia HCFC26
    host cell factor C2
    67(a)
    1 ↔ 1
    5(18230240-18249537)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.172372 Transcribed sequence with weak similarity to protein more 76.81(n)    AL959953.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.184042 Transcribed sequence with moderate similarity to protein more 76.44(n)    AL918253.1 


    ENSEMBL Gene Tree for HCFC2 (if available)
    TreeFam Gene Tree for HCFC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HCFC2 gene
    KLHDC22  KLHDC32  HCFC12  KLHDC12  LZTR12  RABEPK2  KLHDC102  
    1 SIMAP similar gene for HCFC2 using alignment to 3 protein entries:     HCFC2_HUMAN (see all proteins):
    HCFC1

    Find genes that share paralogs with HCFC2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HCFC2
    PGOHUM00000248683


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HCFC2 (see all 797)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1118481711,2
    C--104456387(+) AATTTC/TTTCTT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs750345801,2
    C--104456391(+) TTTTCG/TTCCAC 1 -- us2k10--------
    rs1419733211,2
    --104456396(+) TTCCAC/GTGGAC 1 -- us2k10--------
    rs43401241,2
    C,F,A,H--104456428(+) CTTTAA/CTAAAA 1 -- us2k1 tfbs36Minor allele frequency- C:0.12NS NA EA 370
    rs1473305161,2
    C--104456520(+) AGTGCC/TGGGAT 1 -- us2k10--------
    rs1402828121,2
    --104456611(+) ACAATA/GTGAAG 1 -- us2k10--------
    rs1175948781,2
    C,F--104456642(+) GGTCCC/TCAGTC 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1819242761,2
    --104456664(+) GTCCTC/TGGCCT 1 -- us2k10--------
    rs1442323491,2
    --104456665(+) TCCTCA/GGCCTG 1 -- us2k10--------
    rs1862964731,2
    --104456722(+) ACCGCA/GCATTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HCFC2 (104458235 - 104500302 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HCFC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746314CNV Deletion23290073
    esv2746313CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HCFC2
    DNA2.0 Custom Variant and Variant Library Synthesis for HCFC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607926    OMIM disorders: --

    2 diseases for HCFC2:    
    About MalaCards
    botulism    herpes simplex

    1 disease from the University of Copenhagen DISEASES database for HCFC2:
    Botulism

    Find genes that share disorders with HCFC2           About GenesLikeMe

    Genetic Association Database (GAD): HCFC2

    Export disorders for HCFC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HCFC2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with HCFC2)
        Utopia: connect your pdf to the dynamic
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    1. Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2. (PubMed id 10196288)1, 2, 3 Johnson K.M.... Wilson A.C. (J. Virol. 1999)
    2. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. (PubMed id 15199122)1, 2 Yokoyama A.... Cleary M.L. (Mol. Cell. Biol. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (J. Virol. 2012)
    5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    6. A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. (PubMed id 20305087)1 Mak A.B....Moffat J. (amp 2010)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29915 HGNC: 24972 AceView: HCFC2 Ensembl:ENSG00000111727 euGenes: HUgn29915
    ECgene: HCFC2 Kegg: 29915 H-InvDB: HCFC2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HCFC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HCFC2 gene:
    Search GeneIP for patents involving HCFC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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