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Aliases for HCFC2 Gene

Aliases for HCFC2 Gene

  • Host Cell Factor C2 2 3 5
  • C2 Factor 3 4
  • HCF-2 3 4
  • HCF2 3

External Ids for HCFC2 Gene

Previous GeneCards Identifiers for HCFC2 Gene

  • GC12P102961
  • GC12P102962
  • GC12P104458
  • GC12P101517

Summaries for HCFC2 Gene

Entrez Gene Summary for HCFC2 Gene

  • This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HCFC2 Gene

HCFC2 (Host Cell Factor C2) is a Protein Coding gene. Diseases associated with HCFC2 include Herpes Simplex. Among its related pathways are Influenza A. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is KLHDC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCFC2 Gene

Genomics for HCFC2 Gene

Regulatory Elements for HCFC2 Gene

Enhancers for HCFC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HCFC2 on UCSC Golden Path with GeneCards custom track

Promoters for HCFC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HCFC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HCFC2 Gene

104,064,457 bp from pter
104,106,525 bp from pter
42,069 bases
Plus strand

Genomic View for HCFC2 Gene

Genes around HCFC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCFC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCFC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCFC2 Gene

Proteins for HCFC2 Gene

  • Protein details for HCFC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Host cell factor 2
    Protein Accession:
    Secondary Accessions:
    • B2R8Q5
    • C0H5X3

    Protein attributes for HCFC2 Gene

    792 amino acids
    Molecular mass:
    86779 Da
    Quaternary structure:
    • Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2.

    Alternative splice isoforms for HCFC2 Gene


neXtProt entry for HCFC2 Gene

Proteomics data for HCFC2 Gene at MOPED

Post-translational modifications for HCFC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HCFC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HCFC2 Gene

Domains & Families for HCFC2 Gene

Suggested Antigen Peptide Sequences for HCFC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 fibronectin type-III domains.
  • Contains 4 Kelch repeats.
  • Contains 3 fibronectin type-III domains.
  • Contains 4 Kelch repeats.
genes like me logo Genes that share domains with HCFC2: view

No data available for Gene Families for HCFC2 Gene

Function for HCFC2 Gene

genes like me logo Genes that share phenotypes with HCFC2: view

Animal Model Products

CRISPR Products

miRNA for HCFC2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HCFC2 Gene

Localization for HCFC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCFC2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for HCFC2 Gene COMPARTMENTS Subcellular localization image for HCFC2 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for HCFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10196288
genes like me logo Genes that share ontologies with HCFC2: view

Pathways & Interactions for HCFC2 Gene

SuperPathways for HCFC2 Gene

Superpath Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with HCFC2: view

Pathways by source for HCFC2 Gene

1 KEGG pathway for HCFC2 Gene

Gene Ontology (GO) - Biological Process for HCFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process TAS 10196288
genes like me logo Genes that share ontologies with HCFC2: view

No data available for SIGNOR curated interactions for HCFC2 Gene

Drugs & Compounds for HCFC2 Gene

No Compound Related Data Available

Transcripts for HCFC2 Gene

Unigene Clusters for HCFC2 Gene

Host cell factor C2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HCFC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - - -
SP2: - - - -
SP3: - - -

Relevant External Links for HCFC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HCFC2 Gene

mRNA expression in normal human tissues for HCFC2 Gene

Protein differential expression in normal tissues from HIPED for HCFC2 Gene

This gene is overexpressed in Heart (36.2) and Testis (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HCFC2 Gene

SOURCE GeneReport for Unigene cluster for HCFC2 Gene Hs.506558

mRNA Expression by UniProt/SwissProt for HCFC2 Gene

Tissue specificity: Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon.
genes like me logo Genes that share expression patterns with HCFC2: view

Protein tissue co-expression partners for HCFC2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HCFC2 Gene

Orthologs for HCFC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HCFC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HCFC2 35
  • 94.53 (n)
  • 94.82 (a)
HCFC2 36
  • 95 (a)
(Canis familiaris)
Mammalia HCFC2 35
  • 94.18 (n)
  • 95.06 (a)
HCFC2 36
  • 95 (a)
(Mus musculus)
Mammalia Hcfc2 35
  • 86.03 (n)
  • 88.55 (a)
Hcfc2 16
Hcfc2 36
  • 90 (a)
(Pan troglodytes)
Mammalia HCFC2 35
  • 99.66 (n)
  • 99.37 (a)
HCFC2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hcfc2 35
  • 86.46 (n)
  • 90.61 (a)
(Monodelphis domestica)
Mammalia HCFC2 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia HCFC2 36
  • 74 (a)
(Gallus gallus)
Aves HCFC2 35
  • 74.96 (n)
  • 75.81 (a)
HCFC2 36
  • 71 (a)
(Anolis carolinensis)
Reptilia HCFC2 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hcfc2 35
  • 73.05 (n)
  • 74.41 (a)
Str.17237 35
(Danio rerio)
Actinopterygii Dr.18404 35
hcfc2 36
  • 53 (a)
Species with no ortholog for HCFC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HCFC2 Gene

Gene Tree for HCFC2 (if available)
Gene Tree for HCFC2 (if available)

Paralogs for HCFC2 Gene

Paralogs for HCFC2 Gene

(1) SIMAP similar genes for HCFC2 Gene using alignment to 3 proteins: Pseudogenes for HCFC2 Gene

genes like me logo Genes that share paralogs with HCFC2: view

Variants for HCFC2 Gene

Sequence variations from dbSNP and Humsavar for HCFC2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17035206 - 104,082,535(+) TAAGG(C/G)GGAAA nc-transcript-variant, reference, missense
VAR_050044 -
rs2009698 -- 104,083,428(-) gtctt(C/T)ccttg intron-variant
rs2010110 -- 104,075,611(-) catgg(C/G)tgtat intron-variant
rs2010117 -- 104,075,505(-) ctcta(G/T)cctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HCFC2 Gene

Variant ID Type Subtype PubMed ID
esv2746313 CNV Deletion 23290073
esv2746314 CNV Deletion 23290073

Variation tolerance for HCFC2 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HCFC2 Gene

Disorders for HCFC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HCFC2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
- elite association - COSMIC cancer census association via MalaCards
Search HCFC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HCFC2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HCFC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HCFC2 Gene

Publications for HCFC2 Gene

  1. Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2. (PMID: 10196288) Johnson K.M. … Wilson A.C. (J. Virol. 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PMID: 22379092) Shamay M. … Hayward S.D. (J. Virol. 2012) 3
  5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PMID: 21903422) Li S. … Dorf M.E. (Immunity 2011) 3

Products for HCFC2 Gene

Sources for HCFC2 Gene