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Aliases for HCFC1R1 Gene

Aliases for HCFC1R1 Gene

  • Host Cell Factor C1 Regulator 1 2 3
  • Host Cell Factor C1 Regulator 1 (XPO1 Dependent) 2 3 5
  • HCF-1 Beta-Propeller-Interacting Protein 3 4
  • HPIP 3 4

External Ids for HCFC1R1 Gene

Previous GeneCards Identifiers for HCFC1R1 Gene

  • GC16M003072
  • GC16M003012
  • GC16M003045

Summaries for HCFC1R1 Gene

GeneCards Summary for HCFC1R1 Gene

HCFC1R1 (Host Cell Factor C1 Regulator 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HCFC1R1 Gene

  • Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCFC1R1 Gene

Genomics for HCFC1R1 Gene

Regulatory Elements for HCFC1R1 Gene

Promoters for HCFC1R1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HCFC1R1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HCFC1R1 Gene

Chromosome:
16
Start:
3,022,620 bp from pter
End:
3,024,296 bp from pter
Size:
1,677 bases
Orientation:
Minus strand

Genomic View for HCFC1R1 Gene

Genes around HCFC1R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HCFC1R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HCFC1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCFC1R1 Gene

Proteins for HCFC1R1 Gene

  • Protein details for HCFC1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWW0-HPIP_HUMAN
    Recommended name:
    Host cell factor C1 regulator 1
    Protein Accession:
    Q9NWW0
    Secondary Accessions:
    • D3DUA7
    • Q68EN7

    Protein attributes for HCFC1R1 Gene

    Size:
    138 amino acids
    Molecular mass:
    15291 Da
    Quaternary structure:
    • Interacts with HCFC1.

    Alternative splice isoforms for HCFC1R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HCFC1R1 Gene

Proteomics data for HCFC1R1 Gene at MOPED

Post-translational modifications for HCFC1R1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for HCFC1R1

No data available for DME Specific Peptides for HCFC1R1 Gene

Domains & Families for HCFC1R1 Gene

Protein Domains for HCFC1R1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HCFC1R1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HCFC1R1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HCFC1R1 Gene

Function for HCFC1R1 Gene

Molecular function for HCFC1R1 Gene

UniProtKB/Swiss-Prot Function:
Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.

Phenotypes for HCFC1R1 Gene

genes like me logo Genes that share phenotypes with HCFC1R1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HCFC1R1 Gene

Localization for HCFC1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCFC1R1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HCFC1R1 Gene COMPARTMENTS Subcellular localization image for HCFC1R1 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for HCFC1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HCFC1R1: view

Pathways & Interactions for HCFC1R1 Gene

SuperPathways for HCFC1R1 Gene

No Data Available

Interacting Proteins for HCFC1R1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000248089%0d%0a9606.ENSP00000309555%0d%0a
Selected Interacting proteins: Q9NWW0-HPIP_HUMAN ENSP00000248089 for HCFC1R1 Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for HCFC1R1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HCFC1R1 Gene

Drugs & Compounds for HCFC1R1 Gene

No Compound Related Data Available

Transcripts for HCFC1R1 Gene

Unigene Clusters for HCFC1R1 Gene

Host cell factor C1 regulator 1 (XPO1 dependent):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HCFC1R1 Gene

No ASD Table

Relevant External Links for HCFC1R1 Gene

GeneLoc Exon Structure for
HCFC1R1
ECgene alternative splicing isoforms for
HCFC1R1

Expression for HCFC1R1 Gene

mRNA expression in normal human tissues for HCFC1R1 Gene

SOURCE GeneReport for Unigene cluster for HCFC1R1 Gene Hs.423103

mRNA Expression by UniProt/SwissProt for HCFC1R1 Gene

Q9NWW0-HPIP_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with HCFC1R1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HCFC1R1 Gene

Orthologs for HCFC1R1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HCFC1R1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HCFC1R1 35
  • 88.8 (n)
  • 85.71 (a)
HCFC1R1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HCFC1R1 35
  • 84.03 (n)
  • 79.83 (a)
HCFC1R1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hcfc1r1 35
  • 83.19 (n)
  • 84.87 (a)
Hcfc1r1 16
Hcfc1r1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HCFC1R1 35
  • 100 (n)
  • 100 (a)
HCFC1R1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hcfc1r1 35
  • 83.33 (n)
  • 82.76 (a)
oppossum
(Monodelphis domestica)
Mammalia HCFC1R1 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HCFC1R1 36
  • 60 (a)
OneToOne
Species with no ortholog for HCFC1R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HCFC1R1 Gene

ENSEMBL:
Gene Tree for HCFC1R1 (if available)
TreeFam:
Gene Tree for HCFC1R1 (if available)

Paralogs for HCFC1R1 Gene

No data available for Paralogs for HCFC1R1 Gene

Variants for HCFC1R1 Gene

Sequence variations from dbSNP and Humsavar for HCFC1R1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_043849 -

Structural Variations from Database of Genomic Variants (DGV) for HCFC1R1 Gene

Variant ID Type Subtype PubMed ID
nsv905162 CNV Gain 21882294
nsv905170 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv509588 CNV Insertion 20534489
nsv510673 CNV Loss 20534489
nsv905185 CNV Loss 21882294
dgv2577n71 CNV Loss 21882294
dgv2578n71 CNV Loss 21882294
nsv905193 CNV Loss 21882294
dgv2579n71 CNV Loss 21882294
nsv905197 CNV Loss 21882294
nsv833125 CNV Loss 17160897

Variation tolerance for HCFC1R1 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HCFC1R1 Gene

HapMap Linkage Disequilibrium report
HCFC1R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCFC1R1 Gene

Disorders for HCFC1R1 Gene

Relevant External Links for HCFC1R1

Genetic Association Database (GAD)
HCFC1R1
Human Genome Epidemiology (HuGE) Navigator
HCFC1R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HCFC1R1

No disorders were found for HCFC1R1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HCFC1R1 Gene

Publications for HCFC1R1 Gene

  1. Interaction of HCF-1 with a cellular nuclear export factor. (PMID: 12235138) Mahajan S.S. … Wilson A.C. (J. Biol. Chem. 2002) 2 3 4 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for HCFC1R1 Gene

Sources for HCFC1R1 Gene

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