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Aliases for HCFC1R1 Gene

Aliases for HCFC1R1 Gene

  • Host Cell Factor C1 Regulator 1 (XPO1 Dependent) 2 3
  • HCF-1 Beta-Propeller-Interacting Protein 3 4
  • HPIP 3 4
  • Host Cell Factor C1 Regulator 1 (XPO1 Dependant) 2
  • Host Cell Factor C1 Regulator 1 3

External Ids for HCFC1R1 Gene

Previous GeneCards Identifiers for HCFC1R1 Gene

  • GC16M003072
  • GC16M003012
  • GC16M003045

Summaries for HCFC1R1 Gene

GeneCards Summary for HCFC1R1 Gene

HCFC1R1 (Host Cell Factor C1 Regulator 1 (XPO1 Dependent)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HCFC1R1 Gene

  • Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCFC1R1 Gene

Genomics for HCFC1R1 Gene

Regulatory Elements for HCFC1R1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HCFC1R1 Gene

3,022,620 bp from pter
3,024,286 bp from pter
1,667 bases
Minus strand

Genomic View for HCFC1R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HCFC1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCFC1R1 Gene

Proteins for HCFC1R1 Gene

  • Protein details for HCFC1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Host cell factor C1 regulator 1
    Protein Accession:
    Secondary Accessions:
    • D3DUA7
    • Q68EN7

    Protein attributes for HCFC1R1 Gene

    138 amino acids
    Molecular mass:
    15291 Da
    Quaternary structure:
    • Interacts with HCFC1.

    Alternative splice isoforms for HCFC1R1 Gene


neXtProt entry for HCFC1R1 Gene

Proteomics data for HCFC1R1 Gene at MOPED

Post-translational modifications for HCFC1R1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HCFC1R1 Gene

Domains for HCFC1R1 Gene

Protein Domains for HCFC1R1 Gene


Suggested Antigen Peptide Sequences for HCFC1R1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HCFC1R1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HCFC1R1 Gene

Function for HCFC1R1 Gene

Molecular function for HCFC1R1 Gene

UniProtKB/Swiss-Prot Function: Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.

Phenotypes for HCFC1R1 Gene

GenomeRNAi human phenotypes for HCFC1R1:
genes like me logo Genes that share phenotypes with HCFC1R1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HCFC1R1 Gene

Localization for HCFC1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCFC1R1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.

Subcellular locations from

Jensen Localization Image for HCFC1R1 Gene COMPARTMENTS Subcellular localization image for HCFC1R1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for HCFC1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HCFC1R1: view

Pathways for HCFC1R1 Gene

SuperPathways for HCFC1R1 Gene

No Data Available

Interacting Proteins for HCFC1R1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9NWW0-HPIP_HUMAN ENSP00000248089 for HCFC1R1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for HCFC1R1 Gene


No data available for Pathways by source for HCFC1R1 Gene

Transcripts for HCFC1R1 Gene

Unigene Clusters for HCFC1R1 Gene

Host cell factor C1 regulator 1 (XPO1 dependent):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCFC1R1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCFC1R1 Gene

No ASD Table

Relevant External Links for HCFC1R1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HCFC1R1 Gene

mRNA expression in normal human tissues for HCFC1R1 Gene

SOURCE GeneReport for Unigene cluster for HCFC1R1 Gene Hs.423103

mRNA Expression by UniProt/SwissProt for HCFC1R1 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with HCFC1R1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for HCFC1R1 Gene

Orthologs for HCFC1R1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HCFC1R1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HCFC1R1 35
  • 100 (n)
  • 100 (a)
HCFC1R1 36
  • 100 (a)
(Bos Taurus)
Mammalia HCFC1R1 35
  • 88.8 (n)
  • 85.71 (a)
HCFC1R1 36
  • 86 (a)
(Canis familiaris)
Mammalia HCFC1R1 35
  • 84.03 (n)
  • 79.83 (a)
HCFC1R1 36
  • 79 (a)
(Mus musculus)
Mammalia Hcfc1r1 35
  • 83.19 (n)
  • 84.87 (a)
Hcfc1r1 16
Hcfc1r1 36
  • 83 (a)
(Monodelphis domestica)
Mammalia HCFC1R1 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia HCFC1R1 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Hcfc1r1 35
  • 83.33 (n)
  • 82.76 (a)
Species with no ortholog for HCFC1R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HCFC1R1 Gene

Gene Tree for HCFC1R1 (if available)
Gene Tree for HCFC1R1 (if available)

Paralogs for HCFC1R1 Gene

No data available for Paralogs for HCFC1R1 Gene

Variants for HCFC1R1 Gene

Sequence variations from dbSNP and Humsavar for HCFC1R1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_043849 -

Structural Variations from Database of Genomic Variants (DGV) for HCFC1R1 Gene

Variant ID Type Subtype PubMed ID
nsv905162 CNV Gain 21882294
nsv905170 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv509588 CNV Insertion 20534489
nsv510673 CNV Loss 20534489
nsv905185 CNV Loss 21882294
dgv2577n71 CNV Loss 21882294
dgv2578n71 CNV Loss 21882294
nsv905193 CNV Loss 21882294
dgv2579n71 CNV Loss 21882294
nsv905197 CNV Loss 21882294
nsv833125 CNV Loss 17160897

Relevant External Links for HCFC1R1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCFC1R1 Gene

Disorders for HCFC1R1 Gene

Relevant External Links for HCFC1R1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HCFC1R1: view

No data available for UniProtKB/Swiss-Prot for HCFC1R1 Gene

Publications for HCFC1R1 Gene

  1. Interaction of HCF-1 with a cellular nuclear export factor. (PMID: 12235138) Mahajan S.S. … Wilson A.C. (J. Biol. Chem. 2002) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for HCFC1R1 Gene

Sources for HCFC1R1 Gene

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