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HCFC1R1 Gene

protein-coding   GIFtS: 35

GC16M003012
host cell factor C1 regulator 1 (XPO1 dependent)
(Previous name: host cell factor C1 regulator 1 (XPO1 dependant) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for HCFC1R1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ20568 1, 2
HPIP 1, 2, 3
MGC70711 2
MGC99622 2
Descriptions
HCF-1 beta-propeller interacting protein 2
HCF-1 beta-propeller-interacting protein 3
host cell factor C1 regulator 1 (XPO1 dependant) 1, 2
host cell factor C1 regulator 1 (XPO1 dependent) 2
External Ids
HGNC: 211981
Entrez Gene: 549852
UniProtKB: Q9NWW03
Ensembl: ENSG000001031457
Search outside databases for aliases for HCFC1R1 gene

Previous GC identifer: GC16M003072

Summaries
for HCFC1R1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HPIP_HUMAN, Q9NWW0
Function: Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of
HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the
pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus

Genomic Location
for HCFC1R1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the HCFC1R1 gene  

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

HCFC1R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M003012:     (about GC identifiers)

Start:
 3,012,627 bp from pter
End:
 3,014,288 bp from pter
Size:
 1,662 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000016.8  NT_037887.4  

Proteins
for HCFC1R1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: HPIP_HUMAN, Q9NWW0 (See protein sequence)
Recommended Name: Host cell factor C1 regulator 1  
Size: 138 amino acids; 15291 Da
Subunit: Interacts with HCFC1
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a
CRM1-dependent manner
Secondary accessions: Q68EN7
Alternative splicing: 2 isoforms:  Q9NWW0-1   Q9NWW0-2   

REFSEQ proteins (3 alternative transcripts): 
NP_001002017.1  NP_001002018.1  NP_060355.1  


ENSEMBL proteins: 
ENSP00000380123 ENSP00000248089 ENSP00000346708 


Human Recombinant Proteins 
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Browse Abnova for Human Recombinant Proteins
               OriGene Purified Recombinant Human Proteins (see all 2): HCFC1R1  

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
GO:0005737 cytoplasm IEA--
About this table

Antibodies for HCFC1R1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for HCFC1R1

Assays for HCFC1R1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for HCFC1R1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9NWW0

Gene Function
for HCFC1R1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (HCFC1R1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001002017

              Applied Biosystems Silencer® siRNAs for HCFC1R1

              Sigma-Aldrich siRNA for HCFC1R1  
                     Sigma-Aldrich shRNA for HCFC1R1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for HCFC1R1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001002017
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001002017
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001002017 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001002018

UniProtKB/Swiss-Prot: HPIP_HUMAN, Q9NWW0
Function: Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of
HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the
pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus

Pathways & Interactions
for HCFC1R1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Invitrogen iPath™ Online BioAtlas - Pathway for HCFC1R1 (Maps provided by GeneGo):
 Role of PBX in fibroblasts signaling pathways

   GeneDecks  HCFC1R1 for the pathways selected above  
About GeneDecksing

 Gene Network CentralTM Interacting Genes and Proteins Network for  HCFC1R1 

  --

Drugs & Compounds
for HCFC1R1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HCFC1R1

Transcripts
for HCFC1R1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (HCFC1R1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001002017

              Sigma-Aldrich siRNA for HCFC1R1  
                     Sigma-Aldrich shRNA for HCFC1R1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001002017  NM_001002018  NM_017885  

REFSEQ mRNAs for HCFC1R1 gene (3 alternative transcripts): 

NM_001002017.1   NM_001002018.1   NM_017885.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001002017  NM_001002018  NM_017885  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001002017
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001002017
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001002017 

Additional cDNA sequence: 

AK000575.1 AK293768.1 AY116892.1 BC064026.1 BC080178.1 CR457245.1 CR594889.1 CR612406.1 

19 DOTS entries:

DT.95084812  DT.408651  DT.92434369  DT.92434372  DT.95079278  DT.408652  DT.92411825  DT.420514 
DT.100044539  DT.120679709  DT.97835341  DT.100806089  DT.95289379  DT.100806086  DT.100834678  DT.95079279 
DT.95079280  DT.100801859  DT.100806090 

24/193 AceView cDNA sequences (see all 193 ):

CA422138 NM_017885 BM769833 W81387 BM795438 CA407673 BM563291 NM_001002018 
AA127040 AI826085 CF541056 AA978265 BX118945 AA369310 BX111176 BM687339 
BQ052173 BQ929195 AY116892 AW250779 AI193077 BM709785 BC064026 BM790570 

highest scoring ESTs for HCFC1R1:

AA125762 AA196235 AA436930 AK000575 AW246920 AY116892 BE274806 BE387736 BE388118 BF681447 

Unigene Cluster for HCFC1R1:

Host cell factor C1 regulator 1 (XPO1 dependent)
Hs.719259  [show with all ESTs]
Unigene Representative Sequence: BM919270


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000396916  ENST00000248089  ENST00000354679  

Expression
for HCFC1R1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HCFC1R1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for HCFC1R1

1 / 2 / 3

5 probe-sets matching HCFC1R1 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
45714_at2, 3 U133-B 1 1.00 1.00 1.00 1.00 AA436930 0.80 1.00 0.91 1
45714_at2, 3 U133-A 1 1.00 1.00 -- -- AA436930 0.80 1.00 0.91 1

218537_at2, 3 U133-A 1 1.00 1.00 -- -- NM_017885 0.60 1.00 0.82 1
45714_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

218537_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  HCFC1R1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.719259

UniProtKB/Swiss-Prot: HPIP_HUMAN, Q9NWW0
Tissue specificity: Widely expressed

Orthologs
for HCFC1R1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for HCFC1R1 gene from 4 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 HCFC1R11   -- host cell factor C1 regulator 1 (XPO1 dependent) 81.29(n)
77.55(a)		 610727  XM_848270.1  XP_853363.1 
cow
(Bos taurus)		 HCFC1R11   -- host cell factor C1 regulator 1 (XPO1 dependent) 88.8(n)
85.71(a)		 535210  NM_001046398.1  NP_001039863.1 
rat
(Rattus norvegicus)		 Hcfc1r11   -- host cell factor C1 regulator 1 (XPO1-dependent) 79.61(n)
80.58(a)		 287097  XM_573052.2  XP_573052.2 
mouse
(Mus musculus)		 Hcfc1r11, 5 175
 host cell factor C1 regulator 1 (XPO1-dependent)1, 5 82.22(n)1
83.33(a)1		 3535021  NM_181821.11  NP_861542.11 
 AK0038655  AK0134385  (see all 6)
About this table        Species with no ortholog for HCFC1R1

ENSEMBL Gene Tree for HCFC1R1

Paralogs
for HCFC1R1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for HCFC1R1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --

Disorders & Mutations
for HCFC1R1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for HCFC1R1

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for HCFC1R1

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for HCFC1R1 gene:

Search for HCFC1R1

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing HCFC1R1

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 54985 HGNC: 21198 AceView: HCFC1R1 Ensembl:ENSG00000103145 euGenes: HUgn54985
ECgene: HCFC1R1 H-InvDB: HCFC1R1

Other Databases showing HCFC1R1

(According to HUGE)
About This Section

   --

Specialized Databases showing HCFC1R1

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for HCFC1R1

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for HCFC1R1

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for HCFC1R1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for HCFC1R1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for HCFC1R1 Browse small molecules at Sigma-Aldrich
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