HCFC1 Gene
protein-coding GIFtS: 56
GCID: GC0XM153213
|
|
host cell factor C1 (VP16-accessory protein)
(Previous symbol: HFC1)
| |
Aliases
for HCFC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Host Cell Factor C1 (VP16-Accessory Protein)1 2 | | HCF2 3 | | HCF11 2 3 5 | | C1 Factor2 3 | | CFF1 2 3 | | VP16 Accessory Protein2 3 | | HCF-11 2 3 | | MGC709251 | | HFC11 2 3 | | MRX32 | | VCAF1 2 3 | | Host Cell Factor 12 |
Export aliases for HCFC1 gene to outside databasesPrevious GC identifers: GC0XM147350 GC0XM149667 GC0XM150798 GC0XM151680 GC0XM152733 GC0XM152866 GC0XM141865 |
Summaries
for HCFC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HCFC1:
This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-likemotif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator isproteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and thecorresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminalchains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplexvirus infection. Alternatively spliced variants which encode different protein isoforms have been described; however,not all variants have been fully characterized. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: HCFC1_HUMAN, P51610Function: Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2.Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase(HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of aTHAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part ofthe NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case ofhuman herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivatorprotein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes
Gene Wiki entry for HCFC1 (Host cell factor C1)
|
Genomic Views
for HCFC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HCFC1 gene promoter:
SRY CBF-B CBF-A Sp1 CP1A CBF(2) CBF-C YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HCFC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCFC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28HCFC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM153213: view genomic region
(about GC identifiers)
Start:
|
153,213,004 bp from pter |
End:
|
153,237,258 bp from pter |
Size:
|
24,255 bases |
Orientation:
|
minus strand |
|
Proteins
for HCFC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HCFC1_HUMAN, P51610 (See
protein sequence)Recommended Name: Host cell factor 1 Size: 2035 amino acids; 208732 Da
Subunit: Composed predominantly of six polypeptides ranging from 110 to 150 kDa and a minor 300 kDa polypeptide. Themajority of N- and C-terminal cleavage products remain tightly, albeit non-covalently, associated. Interacts withPOU2F1, CREB3, ZBTB17, EGR2, E2F4, CREBZF, SP1, GABP2, Sin3 HDAC complex (SIN3A, HDAC1, HDAC2, SUDS3), SAP30, SIN3Band FHL2. Component of a MLL1 complex, composed of at least the core components MLL, ASH2L, HCFC1, WDR5 and RBBP5, aswell as the facultative components BAP18, CHD8, DPY30, E2F6, HCFC2, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MEN1,MGA, KAT8, PELP1, PHF20,. PRP31, RING2, RUVBL1, RUVBL2, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component ofthe MLL5-L complex, composed of at least MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Component of aTHAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Interactsdirectly with OGT; the interaction, which requires the HCFC1 cleavage site domain, glycosylates and promotes theproteolytic processing of HCFC1, retains OGT in the nucleus and impacts the expression of herpes simplex virusimmediate early viral genes. Interacts directly with THAP3 (via its HBM). Interacts (via the Kelch-repeat domain) withTHAP1 (via the HBM); the interaction recruits HCHC1 to the RRM1. Interacts with HCFC1R1 and THAP11. Associates withthe VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association withPOU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate earlygenes. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82,RBBP5, ASH2L, CXXC1, HCFC1 and DPY30. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2,KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with the viral transactivator protein VP16
Subcellular location: Cytoplasm. Nucleus. Note=HCFC1R1 modulates its subcellular localization and overexpression ofHCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. Nuclear in general, but uniquely cytoplasmic in trigeminalganglia, becoming nuclear upon HSV reactivation from the latent state. Non-processed HCFC1 associates with chromatin.Colocalizes with CREB3 and CANX in the ER
Sequence caution: Sequence=CAA55790.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from  and Proteopedia  for HCFC1:4GO6 (3D)
Secondary accessions: Q6P4G5Alternative splicing: 3 isoforms: P51610-1 P51610-2 P51610-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HCFC1: NX_P51610
Post-translational modifications:
Proteolytically cleaved at one or several PPCE--THET sites within the HCF repeats. Further cleavage of the primary N-and C-terminal chains results in a 'trimming' and accumulation of the smaller chains. Cleavage is promoted byO-glycosylation1
O-glycosylated. O-glycosylation promotes proteolytic processing1
Ubiquitinated. Lys-1807 and Lys-1808 are ubiquitinated both via 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.BAP1 mediated deubiquitination of 'Lys-48'-linked polyubiquitin chains; deubiquitination by BAP1 does not seem tostabilize the protein1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51610
HCFC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005325.2
ENSEMBL proteins: ENSP00000309555 ENSP00000399589 ENSP00000359001 ENSP00000346174
Human Recombinant Protein Products:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
HCFC1 for ontologies About GeneDecksing
HCFC1 Antibody Products:
Assay Products for HCFC1: |
Protein
Domains /
Families
for HCFC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HCFC1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P51610ProtoNet protein and cluster: P51610 1 Blocks protein family: IPB011498 Kelch
UniProtKB/Swiss-Prot: HCFC1_HUMAN, P51610Domain: The HCF repeat is a highly specific proteolytic cleavage signalDomain: The kelch repeats fold into a 6-bladed kelch beta-propeller called the beta-propeller domain which mediatesinteraction with HCFC1R1Similarity: Contains 5 Kelch repeats |
Function
for HCFC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HCFC1_HUMAN, P51610Function: Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2.Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase(HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of aTHAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part ofthe NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case ofhuman herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivatorprotein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes Genatlas biochemistry entry for HCFC1:host cell factor 1,binding herpes simplex virus acidic transactivator protein VP 16
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HCFC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HCFC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HCFC1 (NM_005334) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HCFC1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HCFC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCFC1 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
HCFC1 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for HCFC1:
|
Pathways & Interactions
for HCFC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mitochondrial Gene Expression | |
1  BioSystems Pathway for HCFC1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HCFC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/111 Interacting proteins for HCFC1 (P516101, 3 ENSP000003095554) via UniProtKB, MINT, STRING, and/or I2D (see all 111)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CREBZF | Q9NS371, 3, ENSP000002600584 | EBI-2832627,EBI-632965 I2D:
score=4 STRING: ENSP00000260058 | | GABPA | Q065461, 3, ENSP000003468864 | EBI-2832627,EBI-638925 I2D:
score=4 STRING: ENSP00000346886 | | ASH2L | Q9UBL31, 3, ENSP000003408964 | EBI-2832627,EBI-540797 I2D:
score=3 STRING: ENSP00000340896 | | GABPB1 | Q065471, 3, ENSP000003702594 | EBI-2832627,EBI-618165 I2D:
score=3 STRING: ENSP00000370259 | | SUDS3 | Q9H7L91, 3, ENSP000003806954 | EBI-2832627,EBI-540496 I2D:
score=2 STRING: ENSP00000380695 |
About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
ISS | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IDA | 12670868 | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 8392914 | | GO:0007049 | cell cycle |
IEA | -- | | GO:0010628 | positive regulation of gene expression |
IDA | -- |
HCFC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HCFC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HCFC1 for compounds About GeneDecksing
 Browse Tocris compounds for HCFC1
3 Novoseek chemical compound relationships for HCFC1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tetrapeptide |
45.5 |
4 |
12235138 (1), 16633736 (1), 10629049 (1) |
| zinc |
9.22 |
2 |
14532282 (2) |
| leucine |
1.21 |
1 |
9658067 (1) |
Search CenterWatch for drugs/clinical trials and news about HCFC1
|
Transcripts
for HCFC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HCFC1 gene: NM_005334.2 Unigene Cluster for HCFC1: Host cell factor C1 (VP16-accessory protein) Hs.83634 [show with all ESTs]Unigene Representative Sequence: NM_0053345 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000310441(uc004fjp.3) ENST00000444191 ENST00000369984 ENST00000461098
ENST00000354233
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HCFC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HCFC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HCFC1 (NM_005334) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HCFC1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HCFC1 |
Additional cDNA sequence: BC010606.1 BC019887.1 BC030560.1 BC063435.1 BC128530.1 DQ655939.2 L20010.1 10 DOTS entries: DT.100863360 DT.95297621 DT.101966970 DT.75127210 DT.97846713 DT.100732562 DT.95192283 DT.95237996 DT.75160807 DT.95254775 24/289 AceView cDNA sequences (see all 289): BQ694252 BM905814 AW501099 AI619945 BC019887 AI916867 AA865726 AI360118 BX363034 BM141932 BM722759 BE669721 L20010 AI702070 BQ228663 AI634433 BM479634 AW136279 AI597756 AI076566 BM458519 BC010606 AA595035 BQ218739
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HCFC1 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · | 21b | · | 21c | · | 21d | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HCFC1
|
Expression
for HCFC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HCFC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACTCAGGC
About this image
See HCFC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HCFC1
SOURCE GeneReport for Unigene cluster: Hs.83634
UniProtKB/Swiss-Prot: HCFC1_HUMAN, P51610Tissue specificity: Highly expressed in fetal tissues and the adult kidney. Present in all tissues tested
SABiosciences Custom PCR Arrays for HCFC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HCFC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HCFC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HCFC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HCFC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCFC1 |
Orthologs
for HCFC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HCFC1 gene from 6/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
HCFC16 |
-- |
75(a) |
1 ↔ 1 |
2(88372946-88399757) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.71032 |
Transcribed sequence with moderate similarity to protein more |
80.27(n) |
|
AL889688.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
hcfc1a1 |
host cell factor C1a |
68.21(n)
74.51(a) |
|
564853 NM_001045064.1 NP_001038529.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Hcf3 |
transcription factor |
53(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
hcf-11 |
Protein HCF-1 |
51.84(n)
50.28(a) |
|
177560 NM_068878.3 NP_501279.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G741506AT1G186106 |
kelch motif-containing proteingalactose oxidase/kelch repeat domain-containing p... |
15(a)14(a) |
possible orthologpossible ortholog |
1(27880528-27883626) 1(6405645-6409297) |
ENSEMBL Gene Tree for HCFC1 (if available)
TreeFam Gene Tree for HCFC1 (if available) |
Paralogs
for HCFC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HCFC1 gene
- KLHDC22 KLHDC32 KLHDC12 LZTR12 RABEPK2 KLHDC102 HCFC22
1 SIMAP similar gene for HCFC1 using alignment to 4 protein entries: HCFC1_HUMAN (see all proteins):HCFC2
HCFC1 for paralogs About GeneDecksing
|
Genomic Variants
for HCFC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HCFC1 (153213004 - 153237258 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HCFC1: --
Locus Specific Mutation Databases (LSDB): HCFC1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HCFC1 |
|
Disorders
/ Diseases
for HCFC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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HCFC1 for disorders About GeneDecksing
OMIM gene information: 300019
OMIM disorders: --
UniProtKB/Swiss-Prot: HCFC1_HUMAN, P51610
Defects in HCFC1 are the cause of mental retardation, X-linked 3 (MRX3) [MIM:309541]. A disorder characterizedby significantly below average general intellectual functioning associated with impairments in adaptative behavior andmanifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation whichalso present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is theonly primary symptom of non-syndromic X-linked mental retardation
9  diseases for HCFC1: About MalaCardsherpes simplex dengue hemorrhagic fever hemorrhagic fever meniere's disease
menieres disease chickenpox leukemia neuronitis
malignant pleural mesothelioma
4 Novoseek disease relationships for HCFC1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: HCFC1 (4 documents)
Export disorders for HCFC1 gene to outside databases
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Publications
for HCFC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for HCFC1 gene, integrated from 9 sources (see all 164):
(articles sorted by number of sources associating them with HCFC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein. (PubMed id 8392914)1, 2, 3, 9 Wilson A.C.... Herr W. (1993)
- The THAP-zinc finger protein THAP1 associates with co activator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonia s. (PubMed id 20200153)1, 2, 9 Mazars R....Girard J.P. (2010)
- Zhangfei is a potent and specific inhibitor of the host cell factor- binding transcription factor Luman. (PubMed id 15705566)1, 2, 9 Misra V.... Korchinski P. (2005)
- Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. (PubMed id 12244100)1, 2, 9 Piluso D.... Capone J.P. (2002)
- Interaction of HCF-1 with a cellular nuclear export factor. (PubMed id 12235138)1, 2, 9 Mahajan S.S.... Wilson A.C. (2002)
- HCF-1 functions as a coactivator for the zinc finger protein Krox20. (PubMed id 14532282)1, 2, 9 Luciano R.L. and Wilson A.C. (2003)
- Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16. (PubMed id 10871379)1, 2, 9 Lu R. and Misra V. (2000)
- The deubiquitinating enzyme BAP1 regulates cell growt h via interaction with HCF-1. (PubMed id 19815555)1, 2, 9 Machida Y.J....Dutta A. (2009)
- Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors. (PubMed id 16624878)1, 2, 9 Vogel J.L. and Kristie T.M. (2006)
- A protein sequestering system reveals control of cellular programs by the transcriptional coactivator HCF-1. (PubMed id 15190068)1, 2, 9 Khurana B. and Kristie T.M. (2004)
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External Searches for HCFC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing HCFC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing HCFC1 gene
(According to HUGE)
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| -- |
Specialized Databases showing HCFC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for HCFC1 | Pharmacogenomics, SNPs, Pathways |
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| | |
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| Patent Information for HCFC1 gene:
Search GeneIP for patents involving HCFC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HCFC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HCFC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HCFC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HCFC1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HCFC1 | | OriGene 3'-UTR Clone for HCFC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HCFC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HCFC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HCFC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HCFC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCFC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HCFC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HCFC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HCFC1 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCFC1 |
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| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HCFC1 |
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