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Aliases &
Descriptions
for HCFC1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| CFF 1, 2, 3 | | HCF 3 | | HCF-1 1, 2, 3 | | HCF1 1, 2, 3, 5 | | HFC1 2, 3 | | MGC70925 1, 2 | | VCAF 1, 2, 3 |
| | | Descriptions |
|---|
| C1 factor 3 | | VP16 accessory protein 3 | | host cell factor 1 2 | | host cell factor C1 (VP16-accessory protein) 2 |
|
| |
Search outside databases for aliases for HCFC1 genePrevious GC identifers: GC0XM147350 GC0XM149667 GC0XM150798 GC0XM151680 GC0XM152733 |
Summaries
for HCFC1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HCFC1:
This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats,
a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage
signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites,
resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final
form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is
involved in control of the cell cycle and transcriptional regulation during herpes simplex virus
infection. Alternatively spliced variants which encode different protein isoforms have been
described; however, not all variants have been fully characterized. [provided by RefSeq]
UniProtKB/Swiss-Prot: HCFC1_HUMAN, P51610Function: Involved in control of the cell cycle. Upon lytic infection of permissive cells, the HSV
transactivator protein VP16 associates with HCFC1. Binding to HCFC1 activates VP16 for association
with the octamer motif-binding protein POU2F1, to form a multiprotein-DNA complex responsible for
activating transcription of the HSV immediate early genes. Also antagonizes transactivation by
ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability
to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone
H3-K4 methyltransferase (HMT) and Sin3 histone deacetylase (HDAC) complexes (involved in the
activation and repression of transcription, respectively) togetherGene Wiki entry for HCFC1 (Host_cell_factor_C1) |
Genomic Location
for HCFC1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the HCFC1 gene 
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28HCFC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM152866:
(about GC identifiers)
Start:
|
152,866,202 bp from pter |
End:
|
152,890,013 bp from pter |
Size:
|
23,812 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011726.13
| Proteins
for HCFC1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HCFC1_HUMAN, P51610 (See
protein sequence)Recommended Name: Host cell factor Size: 2035 amino acids; 208732 Da
Subunit: Composed predominantly of six polypeptides ranging from 110 to 150 kDa and a minor 300 kDa
polypeptide. The majority of N- and C-terminal cleavage products remain tightly, albeit
non-covalently, associated. Interacts with POU2F1, VP16, CREB3, ZBTB17, EGR2, E2F4, CREBZF, SP1,
GABP2, Sin3 HDAC complex (SIN3A, HDAC1, HDAC2, SDS3), Set1/Ash2 HMT complex (SET1, ASH2, WDR5),
SAP30, SIN3B, OGT1 and FHL2. Component of the MLL complex, at least composed of MLL, ASH2L, RBBP5,
DPY30, WDR5, MEN1, HCFC1 and HCFC2. Interacts with HCFC1R1 and THAP11
Subcellular location: Cytoplasm. Nucleus. Note=HCFC1R1 modulates its subcellular localization and
overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm
Secondary accessions: Q6P4G5Alternative splicing: 3 isoforms: P51610-1 P51610-2 P51610-3 Post-translational modifications:
Proteolytically cleaved at one or several PPCE--THET sites within the HCF repeats. Further cleavage
of the primary N- and C-terminal chains results in a 'trimming' and accumulation of the smaller
chains1
O-glycosylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005325.2
ENSEMBL proteins: ENSP00000346174 ENSP00000309555 ENSP00000359001
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HCFC1:
Assays for HCFC1: | Protein
Domains/
Families
for HCFC1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P51610
ProtoNet protein and cluster: P51610 1 Blocks protein family: IPB011498 Kelch
UniProtKB/Swiss-Prot: HCFC1_HUMAN, P51610Domain: The HCF repeat is a highly specific proteolytic cleavage signalDomain: The kelch repeats fold into a 6-bladed kelch beta-propeller called the beta-propeller
domain which mediates interaction with HCFC1R1Similarity: Contains 5 Kelch repeats | Gene Function
for HCFC1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005334
 Applied Biosystems Silencer® siRNAs for HCFC1
 Sigma-Aldrich siRNA and siRNA Panels for HCFC1
Sigma-Aldrich shRNA for HCFC1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005334
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005334
untagged cDNA clones in CMV expression vector (see all 2): NM_005334
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_005334
UniProtKB/Swiss-Prot: HCFC1_HUMAN, P51610Function: Involved in control of the cell cycle. Upon lytic infection of permissive cells, the HSV
transactivator protein VP16 associates with HCFC1. Binding to HCFC1 activates VP16 for association
with the octamer motif-binding protein POU2F1, to form a multiprotein-DNA complex responsible for
activating transcription of the HSV immediate early genes. Also antagonizes transactivation by
ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability
to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone
H3-K4 methyltransferase (HMT) and Sin3 histone deacetylase (HDAC) complexes (involved in the
activation and repression of transcription, respectively) togetherGenatlas biochemistry entry for HCFC1:host cell factor 1,binding herpes simplex virus acidic transactivator protein VP 163 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for HCFC1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for HCFC1
5/39 Interacting proteins for HCFC1 (ENSP000003095553 P516101) via UniProtKB, MINT, and/or STRING (see all 39
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds
for HCFC1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HCFC1
3  Novoseek chemical compound relationships for HCFC1 gene
About this table
|
Transcripts
for HCFC1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005334
Sigma-Aldrich siRNA and siRNA Panels for HCFC1
Sigma-Aldrich shRNA for HCFC1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_005334 REFSEQ mRNAs for HCFC1 gene: NM_005334.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005334
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005334
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005334
untagged cDNA clones in CMV expression vector (see all 2): NM_005334
Additional cDNA sequence: BC010606.1 BC019887.1 BC030560.1 BC063435.1 BC128530.1 DQ655939.2 L20010.1 10 DOTS entries: DT.100863360 DT.95297621 DT.101966970 DT.75127210 DT.97846713 DT.100732562 DT.95192283 DT.95237996 DT.75160807 DT.95254775 24/289 AceView cDNA sequences (see all 289
):BU684010 W73732 BQ694252 BM700192 BU616283 BQ228663 AI634433 AI076566 AA595035 AI248421 AW136279 BQ063822 L20010 BM479634 AA865726 BX414800 BM905814 BM746145 F37316 AI185261 BM996231 AI360118 BC010606 CB054772
 highest scoring ESTs for HCFC1:BI819529 BI858458 BI916213 L20010 AA194813 AA195000 AA259144 AA263124 AA304696 AA470403 Unigene Cluster for HCFC1: Host cell factor C1 (VP16-accessory protein) Hs.83634 [show with all ESTs]Unigene Representative Sequence: NM_005334
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HCFC1 (see all 10
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · | 21b | · | 21c | · | 21d | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for HCFC1
3 Ensembl transcripts including schematic representations: ENST00000354233
ENST00000310441
ENST00000369984
|
Expression
for HCFC1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HCFC1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HCFC1
1 / 2 / 3 5 probe-sets matching HCFC1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GAACTCAGGC
SOURCE GeneReport for Unigene cluster: Hs.83634
Expression variation in blood from EXPOLDB for HCFC1 UniProtKB/Swiss-Prot: HCFC1_HUMAN, P51610Tissue specificity: Highly expressed in fetal tissues and the adult kidney. Present in all tissues
tested |
Orthologs
for HCFC1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HCFC1 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for HCFC1
ENSEMBL Gene Tree for HCFC1 | Paralogs
for HCFC1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for HCFC1 gene
- KLHDC102 RABEPK2 HCFC22
|
SNPs/Variants
for HCFC1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HCFC1 (up to first 250kb)
|
Disorders & Mutations
for HCFC1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300019
4 Novoseek disease relationships for HCFC1 gene
About this table
Human Genome Epidemiology Navigator: HCFC1 (1 document)
|
Medical News
for HCFC1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for HCFC1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/101 PubMed articles for HCFC1 gene (see all 101
):- The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein. (PubMed id 8392914)1, 2, 3, 4 Wilson A.C.... Herr W. (1993)
- Zhangfei is a potent and specific inhibitor of the host cell factor- binding transcription factor Luman. (PubMed id 15705566)1, 3, 4 Misra V.... Korchinski P. (2005)
- Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. (PubMed id 12244100)1, 3, 4 Piluso D.... Capone J.P. (2002)
- Interaction of HCF-1 with a cellular nuclear export factor. (PubMed id 12235138)1, 3, 4 Mahajan S.S.... Wilson A.C. (2002)
- HCF-1 functions as a coactivator for the zinc finger protein Krox20. (PubMed id 14532282)1, 3, 4 Luciano R.L. and Wilson A.C. (2003)
- Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16. (PubMed id 10871379)1, 3, 4 Lu R. and Misra V. (2000)
- Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors. (PubMed id 16624878)1, 3, 4 Vogel J.L. and Kristie T.M. (2006)
- A protein sequestering system reveals control of cellular programs by the transcriptional coactivator HCF-1. (PubMed id 15190068)1, 3, 4 Khurana B. and Kristie T.M. (2004)
- Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. (PubMed id 10629049)1, 3, 4 Mahajan S.S. and Wilson A.C. (2000)
- Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. (PubMed id 12670868)1, 3, 4 Wysocka J....Herr W. (2003)
|
Search for HCFC1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HCFC1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HCFC1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HCFC1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for HCFC1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for HCFC1:
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