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HCCS Gene

protein-coding GIFtS: 62

GC0XP011039

holocytochrome c synthase (cytochrome c heme-lyase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CCHL ^¹, ², ³
DKFZp779I1858 ^²
EC 4.4.1.17 ^³
MCOPS7 ^², ⁵
OTTHUMP00000022903 ^²
OTTHUMP00000022904 ^²
OTTHUMP00000022905 ^²

Descriptions
Holocytochrome c-type synthase ^³
holocytochrome c synthase ^²
holocytochrome c synthase (cytochrome c heme-lyase) ^²

External Ids
HGNC: 4837¹
Entrez Gene: 3052²
UniProtKB: P53701³
Ensembl: ENSG00000004961⁷

Search outside databases for aliases for HCCS gene

Previous GC identifers: GC0XP010108 GC0XP009895 GC0XP010425 GC0XP010490 GC0XP010889

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CCHL_HUMAN, P53701

Function: Links covalently the heme group to the apoprotein of cytochrome c (By similarity)

Gene Wiki entry for HCCS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HCCS gene

Entrez Gene cytogenetic band: Xp22.3 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22

HCCS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP011039: (about GC identifiers)

Start:	11,039,342 bp from pter
End:	11,051,122 bp from pter
Size:	11,781 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011757.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CCHL_HUMAN, P53701 (See protein sequence)

Recommended Name: Cytochrome c-type heme lyase

Size: 268 amino acids; 30602 Da

Subcellular location: Mitochondrion inner membrane (Potential)

Secondary accessions: Q502X8

REFSEQ proteins (2 alternative transcripts):

NP_001116080.1 NP_005324.3

ENSEMBL proteins:

ENSP00000326579 ENSP00000370139 ENSP00000370140

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HCCS)
	Human Recombinant Proteins from Abnova (HCCS)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	11827457
GO:0005743	mitochondrial inner membrane	TAS	8661044
GO:0016020	membrane	IEA	--

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Antibodies for HCCS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HCCS
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (HCCS), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HCCS)
	Novus Biologicals Antibodies for HCCS

Assays for HCCS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P53701

ProtoNet protein and cluster: P53701

1 Blocks protein family: IPB000511 Cytochrome c and c1 heme-lyase

UniProtKB/Swiss-Prot: CCHL_HUMAN, P53701

Similarity: Belongs to the cytochrome c-type heme lyase family

Similarity: Contains 2 HRM (heme regulatory motif) repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HCCS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HCCS)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005333

Applied Biosystems Silencer® siRNAs for HCCS

Sigma-Aldrich siRNA for HCCS

Sigma-Aldrich shRNA for HCCS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HCCS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001122608
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001122608
untagged cDNA clones in CMV expression vector (see all 2): NM_001122608

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001122608

UniProtKB/Swiss-Prot: CCHL_HUMAN, P53701

Function: Links covalently the heme group to the apoprotein of cytochrome c (By similarity)

Catalytic activity: Holocytochrome c = apocytochrome c + heme

Enzyme Number (IUBMB): EC 4.4.1.17

Genatlas biochemistry entry for HCCS:

holocytochrome C-type synthetase,putatively involved in electron transport pathway

9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hccs):

	cellular	embryogenesis	growth/size	homeostasis/metabolism
lethality-prenatal/perinatal	life span-post-weaning/aging	muscle	normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004408	holocytochrome-c synthase activity	TAS	8661044
GO:0005506	iron ion binding	IEA	--
GO:0016829	lyase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for HCCS

5/9 Interacting proteins for HCCS (ENSP00000370139³) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARHGAP6	ENSP00000338967³	STRING (score=.937)
SLC1A1	ENSP00000262352³	STRING (score=.918)
COX10	ENSP00000261643³	STRING (score=.902)
FECH	ENSP00000372326³	STRING (score=.899)
CYCS	ENSP00000307786³	STRING (score=.795)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009887	organ morphogenesis	TAS	8661044
GO:0055114	oxidation reduction	TAS	8661044

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HCCS

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HCCS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HCCS)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005333

Sigma-Aldrich siRNA for HCCS

Sigma-Aldrich shRNA for HCCS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001122608 NM_005333

REFSEQ mRNAs for HCCS gene (2 alternative transcripts):

NM_001122608.1 NM_005333.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001122608 NM_005333

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001122608
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001122608
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001122608

Additional cDNA sequence:

AF143324.1 AK097815.1 BC001691.2 BC095455.1 CR594352.1 CR615500.1 CR749578.1 U36787.1

7 DOTS entries:

DT.100822164 DT.95162995 DT.100822162 DT.441375 DT.121283626 DT.100822160 DT.100822169

24/142 AceView cDNA sequences (see all 142 ):

AI674435 BC001691 AL561481 AW444785 AI767240 BM980388 BQ000137 CD369170

CK904880 BQ014124 BE463562 BM841276 AI222717 CB306404 BX364583 AI801013

AA600019 CR594352 CB160415 AK097815 BP372370 C02260 BE504530 AA310250

highest scoring ESTs for HCCS:

AI801013 U36787 AA045318 AA122101 AA281549 AA310250 AA492536 AA514564 AA515086 AA595081

Unigene Cluster for HCCS:

Holocytochrome c synthase (cytochrome c heme-lyase)

Hs.211571 [show with all ESTs]

Unigene Representative Sequence: NM_005333

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for HCCS

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	·	7c
SP1:					-		-		-												-
SP2:							-		-												-
SP3:									-												-
SP4:									-
SP5:

About this scheme

ECgene alternative splicing isoforms for HCCS

3 Ensembl transcripts including schematic representations:

ENST00000321143 ENST00000380762 ENST00000380763

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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HCCS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HCCS

¹ / ² / ³

6 probe-sets matching HCCS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38943_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.95	U36787	1.00	1.00	1.00	1
90576_at²^{, 3}	U95-E	1	1.00	1.00	0.95	1.05	AI801013	1.00	1.00	1.00	1
203745_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI801013	1.00	1.00	1.00	1
203746_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005333	0.60	1.00	0.82	1
203745_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203746_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HCCS for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGCAGAGTG

SOURCE GeneReport for Unigene cluster: Hs.211571
Expression variation in blood from EXPOLDB for HCCS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HCCS gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC480834¹	--	similar to Cytochrome c-type heme lyase (CCHL) (Holocytochrome more	87.06(n) 92.16(a)	480834 XM_537950.2 XP_537950.2
chimpanzee (Pan troglodytes)	LOC465489¹	--	similar to holocytochrome c-type synthetase	92.86(n) 90.6(a)	465489 XM_520928.2 XP_520928.2
cow (Bos taurus)	HCCS¹	--	holocytochrome c synthase	83.27(n) 89.73(a)	506250 XM_582675.3 XP_582675.3
rat (Rattus norvegicus)	Hccs¹	--	holocytochrome c synthetase	85.82(n) 88.06(a)	317444 XM_228867.4 XP_228867.4
mouse (Mus musculus)	Hccs^{1, 5}	X⁵	holocytochrome c synthetase^{1, 5}	85.07(n)¹ 85.07(a)¹	15159¹ NM_008222.3¹ NP_032248.2¹ AA445869⁵ AK028608⁵ (see all 12)

About this table Species with no ortholog for HCCS

ENSEMBL Gene Tree for HCCS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/22 NCBI SNPs in HCCS are shown (see all 22 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 9)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2070163^1,2	C	11042990(+)	`CACTGC/TGGCTG`	2	A/V	mis¹		1		NA	44
	rs3761635^1,2	H	11038333(-)	`CTCCCG/ACAATT`	1	--	ng5¹		4		EU EA WA	418
	rs7885793^1,2	F,H	11046211(+)	`GGATCA/GTTGAT`	1	--	int¹		4		EU EA WA	418
--	rs35297358^1,2	--	11039396(+)	`AGGAA-/GGCGGCGG`	2	--	ut5¹		0	--	--	--	--
--	rs56814193^1,2	--	11039410(+)	`CGGCG-/GCGGC GGCGGCGTGAAG`	2	--	ut5¹		0	--	--	--	--
--	rs59250760^1,2	--	11051532(+)	`GGGGG-/GTGGGG`	1	--	ng3¹		0	--	--	--	--
--	rs3086668^1,2	--	11039421(+)	`cggcg-/GCGTGAAG`	2	--	ut5¹		0	--	--	--	--
--	rs35884862^1,2	--	11039422(+)	`GGCGT-/GCGGAAGT`	2	--	ut5¹		0	--	--	--	--
--	rs5901444^1,2	--	11039404(+)	`ggcgg-/CGGcggcg`	2	--	ut5¹		0	--	--	--	--
--	rs34658733^1,2	--	11039405(+)	`GCGGC-/CGGGGCGG`	2	--	ut5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for HCCS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300056 disorders: 309801

UniProtKB/Swiss-Prot: CCHL_HUMAN, P53701

Defects in HCCS are a cause of microphthalmia syndromic type 7 (MCOPS7) [MIM:309801]; also

known as microphthalmia with linear skin defects (MLS) or MIDAS syndrome. Microphthalmia is a

clinically heterogeneous disorder of eye formation, ranging from small size of a single eye TO

complete bilateral absence of ocular tissues (anophthalmia). In many cases,

microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular

abnormalities. MCOPS7 is a disorder characterized by unilateral or bilateral microphthalmia,

linear skin defects in affected females, and in utero lethality for males. Skin defects are

limited to the face and neck, consisting of areas of aplastic skin that heal with age to form

hyperpigmented areas. Additional features in female patients include agenesis of the corpus

callosum, sclerocornea, chorioretinal abnormalities, infantile seizures, congenital heart defect,

mental retardation, and diaphragmatic hernia

1 Novoseek disease relationship for HCCS gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
microphthalmia	88.44	4	17893649 (1), 9674913 (1), 15576047 (1), 8661044 (1)

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1 PharmGKB disease relationship for HCCS gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

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Human Gene Mutation Database: HCCS

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/24 PubMed articles for HCCS gene (see all 24 ):

Mutations of the mitochondrial holocytochrome c-type synthase in X- linked dominant microphthalmia with linear skin defects syndrome. (PubMed id 17033964)^{1, 3, 4} Wimplinger I.... Kutsche K. (2006)
Cloning and characterization of a putative human holocytochrome c- type synthetase gene (HCCS) isolated from the critical region for microphthalmia with linear skin defects (MLS). (PubMed id 8661044)^{1, 3, 4} Schaefer L.... Zoghbi H.Y. (1996)
Genomic structure of a human holocytochrome c-type synthetase gene in Xp22.3 and mutation analysis in patients with Rett syndrome. (PubMed id 9674913)^{1, 3, 4} van den Veyver I.B.... Zoghbi H.Y. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complementation of a yeast CYC3 deficiency identifies an X-linked mammalian activator of apocytochrome c. (PubMed id 11827457)^{1, 3} Schwarz Q.P. and Cox T.C. (2002)
HCCS loss-of-function missense mutation in a female with bilateral microphthalmia and sclerocornea: a novel gene for severe ocular malformations? (PubMed id 17893649)^{1, 3} Wimplinger I....Kutsche K. (2007)
MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction. (PubMed id 16263763)³ Nakashima-Kamimura N....Ohta S. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. (PubMed id 12730115)⁷ Ross M.E....Downing J.R. (2003)
Loss of holocytochrome c-type synthetase causes the male lethality of X-linked dominant microphthalmia with linear skin defects (MLS) syndrome. (PubMed id 12444108)³ Prakash S.K....Van Den Veyver I.B. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3052	HGNC: 4837	AceView: HCCS	Ensembl:ENSG00000004961	euGenes: HUgn3052
ECgene: HCCS	H-InvDB: HCCS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=HCCS

Licensable Technologies for HCCS
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for HCCS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HCCS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HCCS		Antibodies for HCCS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HCCS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HCCS)
	Antibodies (HCCS)
	Chimera RNAi (HCCS)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (HCCS)
	Antibodies (HCCS)

Search OriGene for HCCS

Search Tocris compounds for HCCS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HCCS

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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HCCS Gene at Home site.
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HCCS Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for HCCS

Summaries
for HCCS

Genomic Location
for HCCS

Proteins
for HCCS

Protein Domains/
Families
for HCCS

Gene Function
for HCCS

Pathways & Interactions
for HCCS

Drugs & Compounds
for HCCS

Transcripts
for HCCS

Expression
for HCCS

Orthologs
for HCCS

Paralogs
for HCCS

SNPs/Variants
for HCCS

Disorders & Mutations
for HCCS

Medical News
for HCCS

Publications
for HCCS

Search for HCCS

Genome Databases showing HCCS

Other Databases showing HCCS

Specialized Databases showing HCCS

Licensable Technologies
for HCCS

Services
for HCCS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HCCS Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor HCCS

Summariesfor HCCS

Genomic Locationfor HCCS

Proteinsfor HCCS

Protein Domains/Familiesfor HCCS

Gene Functionfor HCCS

Pathways & Interactionsfor HCCS

Drugs & Compoundsfor HCCS

Transcriptsfor HCCS

Expression for HCCS

Orthologsfor HCCS

Paralogsfor HCCS

SNPs/Variantsfor HCCS

Disorders & Mutationsfor HCCS

Medical Newsfor HCCS

Publicationsfor HCCS

Search for HCCS

Genome Databases showing HCCS

Other Databases showing HCCS

Specialized Databases showing HCCS

Licensable Technologiesfor HCCS

Servicesfor HCCS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HCCS

Summaries
for HCCS

Genomic Location
for HCCS

Proteins
for HCCS

Protein Domains/
Families
for HCCS

Gene Function
for HCCS

Pathways & Interactions
for HCCS

Drugs & Compounds
for HCCS

Transcripts
for HCCS

Expression
for HCCS

Orthologs
for HCCS

Paralogs
for HCCS

SNPs/Variants
for HCCS

Disorders & Mutations
for HCCS

Medical News
for HCCS

Publications
for HCCS

Licensable Technologies
for HCCS

Services
for HCCS