Aliases for HCAR3 Gene
External Ids for HCAR3 Gene
Previous Symbols for HCAR3 Gene
GeneCards Summary for HCAR3 Gene
HCAR3 (Hydroxycarboxylic Acid Receptor 3) is a Protein Coding gene. Diseases associated with HCAR3 include distal hereditary motor neuropathy, type ii. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is HCAR1.
UniProtKB/Swiss-Prot for HCAR3 Gene
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
Nicotinic acid receptors are a group of Gi/Go protein-coupled receptors that are currently divided into GPR81, GPR109A and GPR109B subtypes. GPR109B receptors originated from a gene duplication of GPR109A and have > 95% homology. All subtypes are widely expressed throughout adipose tissue and are found at lower levels on macrophages, neutrophils, Langerhans cells and in the spleen. Nicotinic acid receptors are involved in the inhibition of lipolysis. The human genes encoding these receptors are located on chromosome 12 (12q24.3).