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Aliases for HCAR3 Gene

Aliases for HCAR3 Gene

  • Hydroxycarboxylic Acid Receptor 3 2 3
  • GPR109B 3 4 6
  • G-Protein Coupled Receptor HM74B 3 4
  • G Protein-Coupled Receptor 109B 2 3
  • G-Protein Coupled Receptor 109B 3 4
  • G-Protein Coupled Receptor HM74 3 4
  • Nicotinic Acid Receptor 2 3 4
  • Niacin Receptor 2 3 4
  • PUMAG 3 6
  • HCA3 3 4
  • HM74 3 6
  • Hydroxy-Carboxylic Acid Receptor 3 3
  • Putative Chemokine Receptor 3
  • GTP-Binding Protein 3
  • Puma-G 3
  • NIACR2 4
  • HM74b 4

External Ids for HCAR3 Gene

Previous HGNC Symbols for HCAR3 Gene

  • GPR109B

Previous GeneCards Identifiers for HCAR3 Gene

  • GC12M123200

Summaries for HCAR3 Gene

GeneCards Summary for HCAR3 Gene

HCAR3 (Hydroxycarboxylic Acid Receptor 3) is a Protein Coding gene. Diseases associated with HCAR3 include distal hereditary motor neuropathy, type ii. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is HCAR1.

UniProtKB/Swiss-Prot for HCAR3 Gene

  • Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.

Gene Wiki entry for HCAR3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCAR3 Gene

Genomics for HCAR3 Gene

Genomic Location for HCAR3 Gene

Start:
122,714,756 bp from pter
End:
122,716,892 bp from pter
Size:
2,137 bases
Orientation:
Minus strand

Genomic View for HCAR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HCAR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCAR3 Gene

No data available for Regulatory Elements for HCAR3 Gene

Proteins for HCAR3 Gene

  • Protein details for HCAR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49019-HCAR3_HUMAN
    Recommended name:
    Hydroxycarboxylic acid receptor 3
    Protein Accession:
    P49019
    Secondary Accessions:
    • A8K4G5
    • B2R830
    • E9PI97
    • Q8NGE4

    Protein attributes for HCAR3 Gene

    Size:
    387 amino acids
    Molecular mass:
    44478 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HCAR3 Gene

Proteomics data for HCAR3 Gene at MOPED

Post-translational modifications for HCAR3 Gene

No Post-translational modifications

Other Protein References for HCAR3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HCAR3 Gene

Domains for HCAR3 Gene

Gene Families for HCAR3 Gene

HGNC:
  • HCAR :GPCR / Class A : Hydroxy-carboxylic acid receptors
IUPHAR :

Protein Domains for HCAR3 Gene

Suggested Antigen Peptide Sequences for HCAR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49019

UniProtKB/Swiss-Prot:

HCAR3_HUMAN :
  • P49019
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HCAR3: view

Function for HCAR3 Gene

Molecular function for HCAR3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.

Gene Ontology (GO) - Molecular Function for HCAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with HCAR3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCAR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HCAR3 Gene

Localization for HCAR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCAR3 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for HCAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7505609
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HCAR3: view

No data available for Subcellular locations from COMPARTMENTS for HCAR3 Gene

Pathways for HCAR3 Gene

genes like me logo Genes that share pathways with HCAR3: view

Pathways by source for HCAR3 Gene

Interacting Proteins for HCAR3 Gene

Gene Ontology (GO) - Biological Process for HCAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with HCAR3: view

Compounds for HCAR3 Gene

(12) IUPHAR Ligand for HCAR3 Gene

Ligand Type Action Affinity Pubmed IDs
compound 6o [PMID:19524438] Agonist Full agonist 8.52
4-(n-propyl)amino-3-nitrobenzoic acid Agonist Full agonist 7.52
5-methyl-?ae5-(5-meth?aeylthiophe?aen-3-yl)-4?ae-oxo-4,5-?aedihydrofu?aeran-2-car?aeboxylic a?aecid Agonist Full agonist 6.7
1-isopropylbenzotriazole-5-carboxylic acid Agonist Full agonist 6.4
acifran Agonist Full agonist 5.9
D-kynurenine Agonist Full agonist 5.58
2-hydroxyoctanoic acid Agonist Full agonist 5.4
5-ethyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid Agonist Full agonist 5.3
3-hydroxyoctanoic acid Agonist Full agonist 5.1
D-phenyalanine Agonist Full agonist 5.04
D-tryptophan Agonist Full agonist 5.01
nicotinic acid Agonist Unknown

(1) Novoseek inferred chemical compound relationships for HCAR3 Gene

Compound -log(P) Hits PubMed IDs
niacin 84.6 14
genes like me logo Genes that share compounds with HCAR3: view

Transcripts for HCAR3 Gene

mRNA/cDNA for HCAR3 Gene

(68) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HCAR3 Gene

Hydroxycarboxylic acid receptor 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCAR3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCAR3 Gene

No ASD Table

Relevant External Links for HCAR3 Gene

GeneLoc Exon Structure for
HCAR3
ECgene alternative splicing isoforms for
HCAR3

Expression for HCAR3 Gene

mRNA expression in normal human tissues for HCAR3 Gene

SOURCE GeneReport for Unigene cluster for HCAR3 Gene Hs.458425

mRNA Expression by UniProt/SwissProt for HCAR3 Gene

P49019-HCAR3_HUMAN
Tissue specificity: Expression largely restricted to adipose tissue and spleen.
genes like me logo Genes that share expressions with HCAR3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for HCAR3 Gene

Orthologs for HCAR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HCAR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HCAR3 35
  • 83.03 (n)
  • 79.07 (a)
-- 36
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HCAR3 35
  • 83.55 (n)
  • 83.03 (a)
chimpanzee
(Pan troglodytes)
Mammalia GPR109B 35
  • 98.45 (n)
  • 97.67 (a)
HCAR3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Niacr1 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hcar2 35
  • 60.23 (n)
  • 49.84 (a)
zebrafish
(Danio rerio)
Actinopterygii hcar1-3 35
  • 53.01 (n)
  • 43.34 (a)
hcar1-2 36
  • 39 (a)
ManyToMany
Species with no ortholog for HCAR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HCAR3 Gene

ENSEMBL:
Gene Tree for HCAR3 (if available)
TreeFam:
Gene Tree for HCAR3 (if available)

Paralogs for HCAR3 Gene

Paralogs for HCAR3 Gene

Selected SIMAP similar genes for HCAR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HCAR3: view

Variants for HCAR3 Gene

Sequence variations from dbSNP and Humsavar for HCAR3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2548 -- 122,715,122(-) CTTTA(C/G)AGAAA utr-variant-3-prime
rs2550 -- 122,714,930(-) GTTGA(A/G)CAGTT utr-variant-3-prime
rs2551 -- 122,715,198(-) GGAGG(A/G)AGCCC utr-variant-3-prime
rs470535 -- 122,715,611(-) ACCAG(C/G)ATCTC reference, missense
rs478812 -- 122,716,205(+) AGCTG(A/C)TGCAC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for HCAR3 Gene

Variant ID Type Subtype PubMed ID
esv26589 CNV Gain 19812545
esv8582 CNV Loss 19470904
nsv913 CNV Insertion 18451855

Relevant External Links for HCAR3 Gene

HapMap Linkage Disequilibrium report
HCAR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCAR3 Gene

Disorders for HCAR3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HCAR3 Gene in MalaCards »

(1) Diseases for HCAR3 Gene including...

genes like me logo Genes that share disorders with HCAR3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HCAR3 Gene

Publications for HCAR3 Gene

  1. Molecular identification of high and low affinity receptors for nicotinic acid. (PMID: 12522134) Wise A. … Pike N.B. (J. Biol. Chem. 2003) 3 4 23
  2. Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. (PMID: 7505609) Nomura H. … Matsushima K. (Int. Immunol. 1993) 2 3 4
  3. International union of basic and clinical pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B). (PMID: 21454438) Offermanns S. … Ijzerman A.P. (Pharmacol. Rev. 2011) 2 3 4
  4. Nicotinic acid receptor agonists. (PMID: 18983141) Boatman P.D. … Semple G. (J. Med. Chem. 2008) 2 3
  5. Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor. (PMID: 9205127) Zingoni A. … Napolitano M. (Genomics 1997) 2 3

Products for HCAR3 Gene

Sources for HCAR3 Gene

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