Aliases for HCAR2 Gene
External Ids for HCAR2 Gene
Previous Symbols for HCAR2 Gene
GeneCards Summary for HCAR2 Gene
HCAR2 (Hydroxycarboxylic Acid Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include nicotinic acid receptor activity. An important paralog of this gene is HCAR3.
UniProtKB/Swiss-Prot for HCAR2 Gene
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Nicotinic acid receptors are a group of Gi/Go protein-coupled receptors that are currently divided into GPR81, GPR109A and GPR109B subtypes. GPR109B receptors originated from a gene duplication of GPR109A and have > 95% homology. All subtypes are widely expressed throughout adipose tissue and are found at lower levels on macrophages, neutrophils, Langerhans cells and in the spleen. Nicotinic acid receptors are involved in the inhibition of lipolysis. The human genes encoding these receptors are located on chromosome 12 (12q24.3).