HCAR1 Gene

Aliases
for HCAR1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Summaries
for HCAR1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for HCAR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000012.11  NC_018923.2  NT_029419.13  

SwitchGear Promoter luciferase reporter plasmid: HCAR1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HCAR1

HCAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M123104:  view genomic region     (about GC identifiers)

Proteins
for HCAR1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for HCAR1: NX_Q9BXC0

Explore proteomics data for HCAR1 at MOPED

Post-translational modifications: 

HCAR1 Human Recombinant Protein Products:

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	antibodies-online peptides for HCAR1

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	antibodies-online kits for HCAR1 (3 products)

Domains /
Families
for HCAR1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9BXC0

Find genes that share domains with HCAR1           About GenesLikeMe

Function
for HCAR1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

(inferred from 1 allele) (MGI details for Gpr81)

genOway: Develop your customized and physiologically relevant rodent model for HCAR1

miRNA Products:		miRTarBase miRNAs that target HCAR1: hsa-mir-335-5p (MIRT017279)
		Block miRNA regulation of human, mouse, rat HCAR1 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate HCAR1:
		hsa-miR-890 hsa-miR-1276 hsa-miR-3065-3p hsa-miR-1248 hsa-miR-635 hsa-miR-3680 hsa-miR-1305
		SwitchGear 3'UTR luciferase reporter plasmid: HCAR1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for HCAR1
		Predesigned siRNA for gene silencing in human, mouse, rat HCAR1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for HCAR1

Clone Products:		OriGene clones in human, mouse for HCAR1 (see all 6) OriGene ORF clones in mouse, rat for HCAR1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for HCAR1
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HCAR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCAR1

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCAR1

Localization
for HCAR1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for HCAR1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for HCAR1 About     See pathways by source

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	SuperPath	Contained pathways About
1	Peptide ligand-binding receptors	Class A/1 (Rhodopsin-like receptors) 0.71 G alpha (i) signalling events 0.44 GPCR ligand binding 0.71 GPCRs, Class A Rhodopsin-like 0.43
2	Signaling by GPCR	Signaling by GPCR 0.90 Signal Transduction 0.58 GPCR downstream signaling 0.90
3	Hydroxycarboxylic acid-binding receptors	Hydroxycarboxylic acid-binding receptors

1 BioSystems Pathway for HCAR1

GPCRs, Class A Rhodopsin-like

2 Reactome Pathways for HCAR1

	G alpha (i) signalling events
	Hydroxycarboxylic acid-binding receptors

Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for HCAR1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for HCAR1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for HCAR1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HCAR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACATATGCTT

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for HCAR1 OriGene qSTAR qPCR primer pairs in human, mouse for HCAR1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HCAR1
		QuantiTect SYBR Green Assays in human, mouse, rat HCAR1
		QuantiFast Probe-based Assays in human, mouse, rat HCAR1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCAR1

Orthologs
for HCAR1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for HCAR1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for HCAR1 gene

OXER1²  GPR31²  HCAR3²  HCAR2²  

9 SIMAP similar genes for HCAR1 using alignment to 1 protein entry:     HCAR1_HUMAN:

HCAR2    HCAR3    OXER1    GPR31    CYSLTR2    KPG_011

LPAR4    GPR35    GPR17

Find genes that share paralogs with HCAR1           About GenesLikeMe

Genomic Variants
for HCAR1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HCAR1 (see all 168)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs754458731,2	C,F	--	123211660(+)	CTCTAT/GAAAAA	1	--	ds5001		2		WA	120
rs1431481741,2		--	123211709(+)	TACTCA/CCAGCT	1	--	ds5001		0	--	--	--	--
rs16963481,2	C	--	123211817(-)	AATCTC/TGCTCT	1	--	ds5001		12		NA WA CSA EA	374
rs1162963321,2	C	--	123211892(+)	AACTTC/TGATGC	1	--	ds5001		0	--	--	--	--
rs73071921,2	C,F,A	--	123212108(+)	ctcctC/Gggttc	1	--	ds5001		5		NS NA WA	94
rs71317901,2	C,F,A	--	123212123(+)	gattcT/Gcctgc	1	--	ds5001		6		NA NS	92
rs1506955321,2		--	123212195(+)	TTTTAG/TTAGAG	1	--	ut31		0	--	--	--	--
rs73133671,2	C,F,A	--	123212236(+)	CTAGAG/ACTCCT	1	--	ut31		6		NS NA WA CSA	91
rs619550531,2	F	--	123212364(+)	AGAGAG/ATATAA	1	--	ut31		1		NA	2
rs116137751,2	C,H	--	123212385(+)	TGAGAA/CCCATG	1	--	ut31 ese3		5		NS EA NA	422

HapMap Linkage Disequilibrium report for HCAR1 (123104824 - 123215390 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for HCAR1:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv913	CNV	Insertion	18451855

Human Gene Mutation Database (HGMD): HCAR1

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing HCAR1

DNA2.0 Custom Variant and Variant Library Synthesis for HCAR1

Disorders / Diseases
for HCAR1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for HCAR1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. International union of basic and clinical pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B). (PubMed id 21454438)^{1, 2, 3} Offermanns S....Ijzerman A.P. (Pharmacol. Rev. 2011)
2. Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81. (PubMed id 19047060)^{1, 2, 3} Liu C.... Lovenberg T.W. (J. Biol. Chem. 2009)
3. Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155)^{1, 2, 3} Lee D.K.... O'Dowd B.F. (Gene 2001)
4. Role of GPR81 in lactate-mediated reduction of adipose lipolysis. (PubMed id 18952058)^{1, 3} Cai T.Q....Waters M.G. (Biochem. Biophys. Res. Commun. 2008)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)^{1, 2} Takeda S.... Mitaku S. (FEBS Lett. 2002)
7. Biological and pharmacological roles of HCA receptors. (PubMed id 21907911)¹ Blad C.C....Offermanns S. (Adv. Pharmacol. 2011)
8. Study of GPR81, the lactate receptor, from distant species identifies residues and motifs critical for GPR81 functions. (PubMed id 21862690)¹ Kuei C....Liu C. (Mol. Pharmacol. 2011)
9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (Diabetes Care 2010)
10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (Am. J. Hum. Genet. 2009)

External Searches for HCAR1 gene

Genome Databases showing HCAR1 gene

Other Databases showing HCAR1 gene

Specialized Databases showing HCAR1 gene

Products
for HCAR1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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