Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HCAR1 Gene

protein-coding   GIFtS: 50
GCID: GC12M123104

Hydroxycarboxylic Acid Receptor 1

(Previous names: G protein-coupled receptor 104, G protein-coupled receptor...)
(Previous symbols: GPR104, GPR81)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Hydroxycarboxylic Acid Receptor 11 2     G-Protein Coupled Receptor 1042 3
GPR811 2 3 5     G-Protein Coupled Receptor 812 3
GPR1041 2 3     LACR12
G Protein-Coupled Receptor 1041 2     TA-GPCR2
G Protein-Coupled Receptor 811 2     Hydroxy-Carboxylic Acid Receptor 12
Lactate Receptor 11 2     T-Cell Activation G Protein-Coupled Receptor2
HCA12 3     

External Ids:    HGNC: 45321   Entrez Gene: 271982   Ensembl: ENSG000001969177   OMIM: 6069235   UniProtKB: Q9BXC03   

Export aliases for HCAR1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HCAR1 Gene:
G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce
extracellular signals through heterotrimeric G proteins.(supplied by OMIM, Feb 2005)

GeneCards Summary for HCAR1 Gene:
HCAR1 (hydroxycarboxylic acid receptor 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is OXER1.

UniProtKB/Swiss-Prot: HCAR1_HUMAN, Q9BXC0
Function: Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated
pathway

Gene Wiki entry for HCAR1 (GPR81) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for HCAR1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHCAR1 promoter sequence
   Search Chromatin IP Primers for HCAR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HCAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

HCAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCAR1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M123104:  view genomic region     (about GC identifiers)

Start:
123,104,824 bp from pter      End:
123,215,390 bp from pter
Size:
110,567 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HCAR1_HUMAN, Q9BXC0 (See protein sequence)
Recommended Name: Hydroxycarboxylic acid receptor 1  
Size: 346 amino acids; 39295 Da
Secondary accessions: B2R9X4 Q3Y5J3 Q4VBN1 Q6NXU5

Explore the universe of human proteins at neXtProt for HCAR1: NX_Q9BXC0

Explore proteomics data for HCAR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3
  • Modification sites at PhosphoSitePlus

  • See HCAR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115943.1  
    ENSEMBL proteins: 
     ENSP00000409980   ENSP00000349478   ENSP00000389255  
    Reactome Protein details: Q9BXC0

    HCAR1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HCAR1
    GenScript Custom Purified and Recombinant Proteins Services for HCAR1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HCAR1 

     
    antibodies-online proteins for HCAR1 

     
    antibodies-online peptides for HCAR1

    HCAR1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HCAR1
    OriGene Custom Antibody Services for HCAR1
    Novus Biologicals HCAR1 Antibodies
    Search for Antibodies for HCAR1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for HCAR1
    antibodies-online antibodies for HCAR1 (59 products) 

    HCAR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HCAR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HCAR1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HCAR1 
    antibodies-online kits for HCAR1 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HCAR: GPCR / Class A : Hydroxy-carboxylic acid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: HCA1 receptor
    Hydroxycarboxylic acid receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR028016 HCAR1_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9BXC0

    ProtoNet protein and cluster: Q9BXC0

    UniProtKB/Swiss-Prot: HCAR1_HUMAN, Q9BXC0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with HCAR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HCAR1_HUMAN, Q9BXC0
    Function: Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated
    pathway

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    Find genes that share ontologies with HCAR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HCAR1:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gpr81):
     homeostasis/metabolism 

    Find genes that share phenotypes with HCAR1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HCAR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HCAR1:
    hsa-mir-335-5p (MIRT017279)

    Block miRNA regulation of human, mouse, rat HCAR1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate HCAR1:
    hsa-miR-890 hsa-miR-1276 hsa-miR-3065-3p hsa-miR-1248 hsa-miR-635 hsa-miR-3680 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidHCAR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HCAR1
    Predesigned siRNA for gene silencing in human, mouse, rat HCAR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HCAR1

    Clone
    Products:
         
    OriGene clones in human, mouse for HCAR1 (see all 6)
    OriGene ORF clones in mouse, rat for HCAR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for HCAR1
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HCAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCAR1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HCAR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HCAR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCAR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HCAR1_HUMAN, Q9BXC0: Cell membrane; Multi-pass membrane protein

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with HCAR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HCAR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Hydroxycarboxylic acid-binding receptors
    Hydroxycarboxylic acid-binding receptors


    Find genes that share SuperPaths with HCAR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HCAR1
        GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for HCAR1
        G alpha (i) signalling events
    Hydroxycarboxylic acid-binding receptors


        Pathway & Disease-focused RT2 Profiler PCR Array including HCAR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HCAR1

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0032355response to estradiol IDA15831516

    Find genes that share ontologies with HCAR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HCAR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Grifolic acidSelective partial GPR120 agonist[80557-12-6]
    26RFaLigand of GPR103; orexigenic neuropeptide[881640-56-8]
    PF9 tetrasodium saltPotent GPR17 agonist[851265-78-6]
    TC-O 9311Potent and selective GPR139 agonist[444932-31-4]
    TUG 891Potent and selective GPR120 agonist[1374516-07-0]

    5 IUPHAR Ligands for HCAR1 (HCA1 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    3,5-dihydroxybenzoic acid
    AgonistFull agonist3.7222434674
    L-lactic acid
    AgonistFull agonist1.3 - 2.8920374963 18952058 19047060 23396314
    D-lactic ?aeacid
    AgonistPartial agonist2.5218952058
    gamma-hydroxybutyric acid
    AgonistFull agonist1.8219047060
    nicotinic acid
    AgonistUnknown1.8212522134



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HCAR1 gene: 
    NM_032554.3  

    Unigene Cluster for HCAR1:

    Hydroxycarboxylic acid receptor 1
    Hs.610873  [show with all ESTs]
    Unigene Representative Sequence: NM_032554
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436083(uc001ucz.3) ENST00000356987(uc001ucw.1) ENST00000432564

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HCAR1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate HCAR1:
    hsa-miR-890 hsa-miR-1276 hsa-miR-3065-3p hsa-miR-1248 hsa-miR-635 hsa-miR-3680 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidHCAR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HCAR1
    Predesigned siRNA for gene silencing in human, mouse, rat HCAR1
    Clone
    Products:
         
    OriGene clones in human, mouse for HCAR1 (see all 6)
    OriGene ORF clones in mouse, rat for HCAR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for HCAR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HCAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCAR1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HCAR1
    OriGene qSTAR qPCR primer pairs in human, mouse for HCAR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HCAR1
      QuantiTect SYBR Green Assays in human, mouse, rat HCAR1
      QuantiFast Probe-based Assays in human, mouse, rat HCAR1

    Additional mRNA sequence: 

    AF345568.1 AK313955.1 AY507143.1 BC066881.1 BC066882.1 BC066883.1 BC067484.1 BC095506.1 
    EU809458.1 

    2 DOTS entries:

    DT.100019050  DT.91958104 

    3 AceView cDNA sequences:

    AK122659 AW848381 BG212812 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HCAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATATGCTT
    HCAR1 Expression
    About this image

    HCAR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HCAR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.610873

    UniProtKB/Swiss-Prot: HCAR1_HUMAN, Q9BXC0
    Tissue specificity: Expressed abundantly in brown and white fat. It also detectable at lower levels in liver,
    kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the
    cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus

        Pathway & Disease-focused RT2 Profiler PCR Array including HCAR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HCAR1
    OriGene qSTAR qPCR primer pairs in human, mouse for HCAR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HCAR1
    QuantiTect SYBR Green Assays in human, mouse, rat HCAR1
    QuantiFast Probe-based Assays in human, mouse, rat HCAR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCAR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for HCAR1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr811 , 5 G protein-coupled receptor 811, 5 81.48(n)1
    80.7(a)1
      5 (63.24 cM)5
    2432701  NM_175520.41  NP_780729.21 
     1238767365 
    zebrafish
    (Danio rerio)
    Actinopterygii hcar1-16
    hydroxycarboxylic acid receptor 1-1
    39(a)
    many ↔ many
    10(45675902-45676888) ENSDARG00000086066


    ENSEMBL Gene Tree for HCAR1 (if available)
    TreeFam Gene Tree for HCAR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HCAR1 gene
    OXER12  GPR312  HCAR32  HCAR22  
    9 SIMAP similar genes for HCAR1 using alignment to 1 protein entry:     HCAR1_HUMAN:
    HCAR2    HCAR3    OXER1    GPR31    CYSLTR2    KPG_011
    LPAR4    GPR35    GPR17

    Find genes that share paralogs with HCAR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HCAR1 (see all 168)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs754458731,2
    C,F--123211660(+) CTCTAT/GAAAAA 1 -- ds50012Minor allele frequency- G:0.19WA 120
    rs1431481741,2
    --123211709(+) TACTCA/CCAGCT 1 -- ds50010--------
    rs16963481,2
    C--123211817(-) AATCTC/TGCTCT 1 -- ds500112Minor allele frequency- T:0.07NA WA CSA EA 374
    rs1162963321,2
    C--123211892(+) AACTTC/TGATGC 1 -- ds50010--------
    rs73071921,2
    C,F,A--123212108(+) ctcctC/Gggttc 1 -- ds50015Minor allele frequency- G:0.45NS NA WA 94
    rs71317901,2
    C,F,A--123212123(+) gattcT/Gcctgc 1 -- ds50016Minor allele frequency- G:0.35NA NS 92
    rs1506955321,2
    --123212195(+) TTTTAG/TTAGAG 1 -- ut310--------
    rs73133671,2
    C,F,A--123212236(+) CTAGAG/ACTCCT 1 -- ut316Minor allele frequency- A:0.42NS NA WA CSA 91
    rs619550531,2
    F--123212364(+) AGAGAG/ATATAA 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs116137751,2
    C,H--123212385(+) TGAGAA/CCCATG 1 -- ut31 ese35Minor allele frequency- C:0.00NS EA NA 422

    HapMap Linkage Disequilibrium report for HCAR1 (123104824 - 123215390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HCAR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv913CNV Insertion18451855

    Human Gene Mutation Database (HGMD): HCAR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HCAR1
    DNA2.0 Custom Variant and Variant Library Synthesis for HCAR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606923    OMIM disorders: --


    Find genes that share disorders with HCAR1           About GenesLikeMe


    Export disorders for HCAR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HCAR1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with HCAR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. International union of basic and clinical pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B). (PubMed id 21454438)1, 2, 3 Offermanns S....Ijzerman A.P. (Pharmacol. Rev. 2011)
    2. Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81. (PubMed id 19047060)1, 2, 3 Liu C.... Lovenberg T.W. (J. Biol. Chem. 2009)
    3. Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155)1, 2, 3 Lee D.K.... O'Dowd B.F. (Gene 2001)
    4. Role of GPR81 in lactate-mediated reduction of adipose lipolysis. (PubMed id 18952058)1, 3 Cai T.Q....Waters M.G. (Biochem. Biophys. Res. Commun. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    7. Biological and pharmacological roles of HCA receptors. (PubMed id 21907911)1 Blad C.C....Offermanns S. (Adv. Pharmacol. 2011)
    8. Study of GPR81, the lactate receptor, from distant species identifies residues and motifs critical for GPR81 functions. (PubMed id 21862690)1 Kuei C....Liu C. (Mol. Pharmacol. 2011)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27198 HGNC: 4532 AceView: GPR81 Ensembl:ENSG00000196917 euGenes: HUgn27198
    ECgene: HCAR1 H-InvDB: HCAR1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HCAR1 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/gpr81/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HCAR1 gene:
    Search GeneIP for patents involving HCAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for HCAR1 (GPR81)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HCAR1   OriGene RNAi products in human, mouse, rat for HCAR1  
     OriGene qPCR primer pairs and template standards for HCAR1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HCAR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for HCAR1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HCAR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HCAR1   OriGene Custom Protein Services for HCAR1  

     
     
     Block miRNA regulation of human, mouse, rat HCAR1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HCAR1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HCAR1 Predesigned siRNA for gene silencing in human, mouse, rat HCAR1
     QuantiFast Probe-based Assays in human, mouse, rat HCAR1 QuantiTect SYBR Green Assays in human, mouse, rat HCAR1
     PCR Arrays including human, mouse, rat HCAR1 Search Chromatin IP Primers for HCAR1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HCAR1  Search GeneGlobe Interaction Network for HCAR1
     Search Regulatory tfbs for HCAR1
     GenScript Custom Purified and Recombinant Proteins Services for HCAR1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for HCAR1
     GenScript Custom Assay Services for HCAR1 GenScript Custom overexpressing Cell Line Services for HCAR1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for HCAR1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HCAR1 antibodies
     Search for Antibodies for HCAR1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HCAR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for HCAR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCAR1
     SwitchGear 3'UTR luciferase reporter plasmids for HCAR1
     SwitchGear Promoter luciferase reporter plasmids for HCAR1
     ThermoFisher Antibodies for HCAR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCAR1
     Browse compounds at ApexBio
     Search Addgene for plasmids for HCAR1
      Search eBioscience for proteins for HCAR1
      Search eBioscience for elisas for HCAR1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HCAR1
     antibodies-online antibodies for HCAR1 (59 products)
     antibodies-online kits for HCAR1 (3 products)
     antibodies-online peptides for HCAR1
     antibodies-online proteins for HCAR1
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HCAR1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4