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HBZ Gene

protein-coding   GIFtS: 54
GCID: GC16P000202

Hemoglobin, Zeta

  See HBZ-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hemoglobin, Zeta1 2     zeta-globin2
Hemoglobin Zeta Chain2 3     HBZ23
HBAZ2 3     Zeta-globin3
Hemoglobin Subunit Zeta2     

External Ids:    HGNC: 48351   Entrez Gene: 30502   Ensembl: ENSG000001306567   OMIM: 1423105   UniProtKB: P020083   

Export aliases for HBZ gene to outside databases

Previous GC identifers: GC16P000221 GC16P000142 GC16P000120


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HBZ Gene:
Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early
embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the
human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is:
5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. (provided by RefSeq, Nov 2009)

GeneCards Summary for HBZ Gene:
HBZ (hemoglobin, zeta) is a protein-coding gene. Diseases associated with HBZ include alpha thalassemia, and spinal cord disease. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is HBE1.

UniProtKB/Swiss-Prot: HBAZ_HUMAN, P02008
Function: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin

Gene Wiki entry for HBZ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HBZ gene promoter:
         CREB   Sp1   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHBZ promoter sequence
   Search Chromatin IP Primers for HBZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HBZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

HBZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HBZ gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000202:  view genomic region     (about GC identifiers)

Start:
202,686 bp from pter      End:
204,504 bp from pter
Size:
1,819 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HBAZ_HUMAN, P02008 (See protein sequence)
Recommended Name: Hemoglobin subunit zeta  
Size: 142 amino acids; 15637 Da
Subunit: Heterotetramer of two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1; two zeta
chains and two gamma chains in fetal hemoglobin Portland-1. Heterotetramer of two zeta chains and two beta chains
in hemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassemia
Developmental stage: Detected in the yolk sac of the early embryo and in erythrocytes from fetal umbilical cord
blood. Detected at lower levels after 18 weeks of gestation. Detected in blood from still-born neoneates with
homozygous alpha-thalassemia (at protein level)
2 PDB 3D structures from and Proteopedia for HBZ:
1JEB (3D)        3W4U (3D)    
Secondary accessions: Q6IBF6

Explore the universe of human proteins at neXtProt for HBZ: NX_P02008

Explore proteomics data for HBZ at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HBZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005323.1  
    ENSEMBL proteins: 
     ENSP00000252951  

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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for HBZ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR012292 Globin_dom
     IPR002338 Haemoglobin_a
     IPR009050 Globin-like
     IPR002340 Haemoglobin_zeta
     IPR000971 Globin

    Graphical View of Domain Structure for InterPro Entry P02008

    ProtoNet protein and cluster: P02008

    3 Blocks protein domains:
    IPB002338 Alpha haemoglobin signature
    IPB002339 Pi haemoglobin signature
    IPB002340 Zeta haemoglobin signature


    UniProtKB/Swiss-Prot: HBAZ_HUMAN, P02008
    Similarity: Belongs to the globin family


    Find genes that share domains with HBZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HBAZ_HUMAN, P02008
    Function: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin

         Genatlas biochemistry entry for HBZ:
    hemoglobin,zeta,embryonic

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005344oxygen transporter activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding IPI11159543
    GO:0019825oxygen binding IEA--
    GO:0020037heme binding IEA--
         
    Find genes that share ontologies with HBZ           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hba-x):
     growth/size/body  hematopoietic system  mortality/aging  reproductive system 

    Find genes that share phenotypes with HBZ           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hba-xHba-tm1Led for HBZ

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HBZ
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HBZ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HBZ

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    Predesigned siRNA for gene silencing in human, mouse, rat HBZ

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005833hemoglobin complex IEA--

    Find genes that share ontologies with HBZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including HBZ: 
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HBZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for HBZ (P020082, 3 ENSP000002529514) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNDP175353, ENSP000002528184I2D: score=1 STRING: ENSP00000252818
    HBBP688713, ENSP000003339944I2D: score=2 STRING: ENSP00000333994
    SP1P080473, ENSP000003293574I2D: score=1 STRING: ENSP00000329357
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    FGFR3P226073I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0043249erythrocyte maturation IEA--

    Find genes that share ontologies with HBZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HBZ (HBAZ)

    1 HMDB Compound for HBZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    1 Novoseek inferred chemical compound relationship for HBZ gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 5.21 1 8508028 (1)



    Find genes that share compounds with HBZ           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HBZ gene: 
    NM_005332.2  

    Unigene Cluster for HBZ:

    Hemoglobin, zeta
    Hs.585357  [show with all ESTs]
    Unigene Representative Sequence: BI833939
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252951(uc002cft.1)
    miRNA
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    GenScript: all cDNA clones in your preferred vector: HBZ (NM_005332)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HBZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HBZ
    Primer
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    OriGene qPCR primer pairs and template standards for HBZ
    OriGene qSTAR qPCR primer pairs in human, mouse for HBZ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HBZ
      QuantiTect SYBR Green Assays in human, mouse, rat HBZ
      QuantiFast Probe-based Assays in human, mouse, rat HBZ

    Additional mRNA sequence: 

    BC027892.1 CR456848.1 M24173.1 

    2 DOTS entries:

    DT.446568  DT.97797418 

    Selected AceView cDNA sequences (see all 53):

    R89375 R92459 AI660353 BC027892 H94426 NM_005332 M24173 T84332 
    CR456848 AJ710994 BX102376 BP432876 H71198 H94946 H58334 BI835106 
    R98069 BI835730 H58398 H58723 H53490 BM695598 H58399 R98313 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HBZ    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                          -     -                     
    SP2:                                                      
    SP3:                                                      
    SP4:        -     -                                       
    SP5:              -     -     -     -                     


    ECgene alternative splicing isoforms for HBZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HBZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGCCAAGA
    HBZ Expression
    About this image


    HBZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac Crescent Cells Cardiac Crescent
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Gonad
             Primordial Germ Cells Allantois
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
    HBZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HBZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.585357

    UniProtKB/Swiss-Prot: HBAZ_HUMAN, P02008
    Tissue specificity: Detected in fetal erythrocytes (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including HBZ: 
              Embryonic Stem Cells in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HBZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HBZ gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hba-x1 , 5 hemoglobin X, alpha-like embryonic chain in Hba complex1, 5 82.16(n)1
    78.17(a)1
      11 (18.86 cM)5
    151261  NM_010405.41  NP_034535.11 
     322764005 
    chicken
    (Gallus gallus)
    Aves LOC1008580801 hemoglobin subunit pi-like 69.72(n)
    71.13(a)
      100858080  XM_003643193.2  XP_003643241.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia X02796.12   -- 71.27(n)    X02796.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY325264.12   -- 76.13(n)   30597  AY325264.1 


    ENSEMBL Gene Tree for HBZ (if available)
    TreeFam Gene Tree for HBZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HBZ gene
    HBE12  HBG22  HBG12  HBD2  HBA22  HBB2  HBQ12  HBA12  
    HBM2  
    11 SIMAP similar genes for HBZ using alignment to 2 protein entries:     HBAZ_HUMAN (see all proteins):
    HBA2    HBA1    HBQ1    HBG1    HBM    HBG2
    HBE1    HBD    HBB    CYGB    MB

    Find genes that share paralogs with HBZ           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HBZ
    PGOHUM00000248958


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HBZ (see all 103)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428750311,2
    --200913(+) AAGGAC/TAGACA 1 -- us2k10--------
    rs1511871921,2
    --200964(+) CTATGC/TCCCAT 1 -- us2k10--------
    rs1868604851,2
    --200999(+) AAGCCA/TACTGA 1 -- us2k10--------
    rs1916519041,2
    --201002(+) CCAACC/TGAATA 1 -- us2k10--------
    rs28589181,2
    C,F,H--201183(+) gaaaaC/Tatagg 1 -- us2k111Minor allele frequency- T:0.21WA NA CSA EA 374
    rs601770501,2
    C,F--201287(+) TAAAAC/GTTTTG 1 -- us2k12Minor allele frequency- G:0.02WA 120
    rs1833142751,2
    --201326(+) AACTAA/CCAAGC 1 -- us2k10--------
    rs66001431,2
    C,F,A,H--201389(+) ccagaA/Cgatac 1 -- us2k134Minor allele frequency- C:0.21NS EA NA WA CSA 2959
    rs1865225631,2
    --201413(+) AATTCA/GTCCTT 1 -- us2k10--------
    rs1403232271,2
    C--201490(+) TCCTAA/GCACTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HBZ (202686 - 204504 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HBZ (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv436840CNV Insertion17901297
    esv1084861CNV Insertion17803354
    dgv2459n71CNV Loss21882294
    dgv2458n71CNV Loss21882294
    dgv2460n71CNV Loss21882294
    nsv518291CNV Loss19592680
    dgv2455n71CNV Loss21882294
    nsv904637CNV Loss21882294
    nsv827474CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HBZ
    DNA2.0 Custom Variant and Variant Library Synthesis for HBZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142310    OMIM disorders: --

    2 diseases for HBZ:    
    About MalaCards
    alpha thalassemia    spinal cord disease

    4 diseases from the University of Copenhagen DISEASES database for HBZ:
    Alpha thalassemia     Adult T-cell leukemia     Tropical spastic paraparesis     Spinal cord disease

    Find genes that share disorders with HBZ           About GenesLikeMe

    2 Novoseek inferred disease relationships for HBZ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha-thalassemia 83.1 8 9544971 (2), 18208812 (1), 1329692 (1), 1975558 (1) (see all 6)
    erythroleukemia 52.6 4 7727787 (1), 9642099 (1)

    GeneTests: HBZ
    GeneReviews: HBZ

    Export disorders for HBZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HBZ gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with HBZ)
        Utopia: connect your pdf to the dynamic
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    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The role of beta chains in the control of the hemoglobin oxygen binding function: chimeric human/mouse proteins, structure, and function. (PubMed id 11747442)1, 2 Kidd R.D.... Brittain T. (Biochemistry 2001)
    3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    4. The relationship between chromosome structure and function at a human telomeric region. (PubMed id 9054936)1, 2 Flint J.... Higgs D.R. (Nat. Genet. 1997)
    5. A review of the molecular genetics of the human alpha-globin gene cluster. (PubMed id 2649166)1, 3 Higgs D.R....Weatherall D.J. (Blood 1989)
    6. The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. (PubMed id 6297773)1, 2 Proudfoot N.J.... Maniatis T. (Cell 1982)
    7. Cloning and nucleotide sequence analysis of human embryonic zeta- globin cDNA. (PubMed id 6963223)1, 2 Cohen-Solal M.... Forget B.G. (DNA 1982)
    8. Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains. (PubMed id 6172357)1, 2 Aschauer H.... Braunitzer G. (Hoppe-Seyler's Z. Physiol. Chem. 1981)
    9. Human embryonic haemoglobins. The primary structure of the zeta chains. (PubMed id 6179844)1, 2 Aschauer H.... Braunitzer G. (Hoppe-Seyler's Z. Physiol. Chem. 1981)
    10. Structure of the zeta chain of human embryonic hemoglobin. (PubMed id 6171809)1, 2 Clegg J.B. and Gagnon J. (Proc. Natl. Acad. Sci. U.S.A. 1981)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3050 HGNC: 4835 AceView: HBZ Ensembl:ENSG00000130656 euGenes: HUgn3050
    ECgene: HBZ H-InvDB: HBZ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HBZ Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=HBZ[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HBZ gene:
    Search GeneIP for patents involving HBZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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