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Aliases for HBZ Gene

Aliases for HBZ Gene

  • Hemoglobin, Zeta 2 3
  • Hemoglobin Zeta Chain 3 4
  • Zeta-Globin 3 4
  • HBAZ 3 4
  • Hemoglobin Subunit Zeta 3
  • HBZ-T1 3
  • HBZ2 4
  • HBZ1 3

External Ids for HBZ Gene

Summaries for HBZ Gene

Entrez Gene Summary for HBZ Gene

  • Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. [provided by RefSeq, Nov 2009]

GeneCards Summary for HBZ Gene

HBZ (Hemoglobin, Zeta) is a Protein Coding gene. Diseases associated with HBZ include spinal cord disease and thalassemias, alpha-. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is HBA2.

UniProtKB/Swiss-Prot for HBZ Gene

  • The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin

Gene Wiki entry for HBZ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HBZ Gene

Genomics for HBZ Gene

Genomic Location for HBZ Gene

142,922 bp from pter
154,505 bp from pter
11,584 bases
Plus strand

Genomic View for HBZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HBZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HBZ Gene

Regulatory Elements for HBZ Gene

Proteins for HBZ Gene

  • Protein details for HBZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hemoglobin subunit zeta
    Protein Accession:
    Secondary Accessions:
    • Q6IBF6

    Protein attributes for HBZ Gene

    142 amino acids
    Molecular mass:
    15637 Da
    Quaternary structure:
    • Heterotetramer of two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1; two zeta chains and two gamma chains in fetal hemoglobin Portland-1. Heterotetramer of two zeta chains and two beta chains in hemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassemia.

    Three dimensional structures from OCA and Proteopedia for HBZ Gene

neXtProt entry for HBZ Gene

Proteomics data for HBZ Gene at MOPED

Post-translational modifications for HBZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HBZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HBZ Gene

Domains for HBZ Gene


  • Belongs to the globin family.:
    • P02008
genes like me logo Genes that share domains with HBZ: view

No data available for Gene Families for HBZ Gene

Function for HBZ Gene

Molecular function for HBZ Gene

GENATLAS Biochemistry: hemoglobin,zeta,embryonic
UniProtKB/Swiss-Prot Function: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin

Gene Ontology (GO) - Molecular Function for HBZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005344 oxygen transporter activity IEA --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 11159543
GO:0019825 oxygen binding IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with HBZ: view
genes like me logo Genes that share phenotypes with HBZ: view

Animal Models for HBZ Gene

MGI Knock Outs for HBZ:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HBZ Gene

Localization for HBZ Gene

Subcellular locations from

Jensen Localization Image for HBZ Gene COMPARTMENTS Subcellular localization image for HBZ gene
Compartment Confidence
cytosol 4
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HBZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005833 hemoglobin complex IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with HBZ: view

Pathways for HBZ Gene

SuperPathways for HBZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for HBZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0015671 oxygen transport IEA --
GO:0043249 erythrocyte maturation IEA --
genes like me logo Genes that share ontologies with HBZ: view

No data available for Pathways by source for HBZ Gene

Compounds for HBZ Gene

(1) HMDB Compounds for HBZ Gene

Compound Synonyms Cas Number PubMed IDs
  • (protoporphyrinato)iron

(1) Novoseek inferred chemical compound relationships for HBZ Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 5.21 1
genes like me logo Genes that share compounds with HBZ: view

Transcripts for HBZ Gene

mRNA/cDNA for HBZ Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(53) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HBZ Gene

Hemoglobin, zeta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HBZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP4: - -
SP5: - - - -

Relevant External Links for HBZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HBZ Gene

mRNA expression in normal human tissues for HBZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HBZ Gene

This gene is overexpressed in Whole Blood (16.5) and Testis (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HBZ Gene

SOURCE GeneReport for Unigene cluster for HBZ Gene Hs.585357

mRNA Expression by UniProt/SwissProt for HBZ Gene

Tissue specificity: Detected in fetal erythrocytes (at protein level).
genes like me logo Genes that share expressions with HBZ: view

Orthologs for HBZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for HBZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 37
  • 83 (a)
-- 37
  • 96 (a)
HBZ 36
  • 98.12 (n)
  • 95.77 (a)
(Bos Taurus)
Mammalia -- 37
  • 85 (a)
-- 37
  • 84 (a)
(Canis familiaris)
Mammalia -- 37
  • 83 (a)
-- 37
  • 70 (a)
LOC100855600 36
  • 88.26 (n)
  • 83.1 (a)
(Mus musculus)
Mammalia Hba-x 36
  • 82.16 (n)
  • 78.17 (a)
Hba-x 16
Hba-x 37
  • 78 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 73 (a)
HBA 37
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia HBZ 37
  • 78 (a)
(Rattus norvegicus)
Mammalia Hbz 36
  • 81.92 (n)
  • 79.58 (a)
(Gallus gallus)
Aves HBZ 37
  • 71 (a)
HBZ 37
  • 71 (a)
LOC100858080 36
  • 69.72 (n)
  • 71.13 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hba4 36
  • 62.91 (n)
  • 65.49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8146 36
(Danio rerio)
Actinopterygii -- 36
HBQ1 37
  • 48 (a)
si:ch211-5k11.6 36
  • 58.22 (n)
  • 57.04 (a)
Species with no ortholog for HBZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HBZ Gene

Gene Tree for HBZ (if available)
Gene Tree for HBZ (if available)

Paralogs for HBZ Gene

Paralogs for HBZ Gene

Selected SIMAP similar genes for HBZ Gene using alignment to 2 proteins: Pseudogenes for HBZ Gene

genes like me logo Genes that share paralogs with HBZ: view

Variants for HBZ Gene

Sequence variations from dbSNP and Humsavar for HBZ Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2077088 -- 150,074(+) ttgcc(A/G)tgagc intron-variant
rs2105901 -- 148,408(+) GATCG(C/T)GCAAC intron-variant
rs2461286 -- 153,255(-) CCTGC(C/T)CTCCT intron-variant
rs2541598 -- 153,133(-) ACAGT(C/G)CCCTC intron-variant
rs2541600 -- 149,541(-) ctggc(C/T)ctgtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HBZ Gene

Variant ID Type Subtype PubMed ID
dgv2455n71 CNV Loss 21882294
esv2422427 CNV Duplication 17116639
nsv518291 CNV Loss 19592680
nsv904635 CNV Gain 21882294
dgv2458n71 CNV Loss 21882294
nsv904637 CNV Loss 21882294
nsv827473 CNV Gain 20364138
dgv2459n71 CNV Loss 21882294
dgv2460n71 CNV Loss 21882294
nsv904646 CNV Gain 21882294
esv1084861 CNV Insertion 17803354
nsv436840 CNV Insertion 17901297
nsv827474 CNV Gain 20364138

Relevant External Links for HBZ Gene

HapMap Linkage Disequilibrium report

Disorders for HBZ Gene

(2) Novoseek inferred disease relationships for HBZ Gene

Disease -log(P) Hits PubMed IDs
alpha-thalassemia 83.1 7
erythroleukemia 52.6 2

Relevant External Links for HBZ

genes like me logo Genes that share disorders with HBZ: view

No data available for UniProtKB/Swiss-Prot for HBZ Gene

Publications for HBZ Gene

  1. Effect of zeta-globin substitution on the O2-transport properties of Hb S in vitro and in vivo. (PMID: 15555579) He Z. … Russell J.E. (Biochem. Biophys. Res. Commun. 2004) 3 23
  2. Structure of the zeta chain of human embryonic hemoglobin. (PMID: 6171809) Clegg J.B. … Gagnon J. (Proc. Natl. Acad. Sci. U.S.A. 1981) 3 4
  3. Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains. (PMID: 6172357) Aschauer H. … Braunitzer G. (Hoppe-Seyler's Z. Physiol. Chem. 1981) 3 4
  4. Human embryonic haemoglobins. The primary structure of the zeta chains. (PMID: 6179844) Aschauer H. … Braunitzer G. (Hoppe-Seyler's Z. Physiol. Chem. 1981) 3 4
  5. The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. (PMID: 6297773) Proudfoot N.J. … Maniatis T. (Cell 1982) 3 4

Products for HBZ Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HBZ
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HBZ
    • Block miRNA regulation of HBZ using miScript Target Protectors

    Sources for HBZ Gene

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