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Aliases for HBQ1 Gene

Aliases for HBQ1 Gene

  • Hemoglobin, Theta 1 2 3
  • Hemoglobin Theta-1 Chain 3 4
  • Theta-1-Globin 3 4
  • Hemoglobin Subunit Theta-1 3
  • HBQ 3

External Ids for HBQ1 Gene

Previous GeneCards Identifiers for HBQ1 Gene

  • GC16P000249
  • GC16P000170
  • GC16P000245
  • GC16P000149
  • GC16P000254
  • GC16P000256
  • GC16P000260
  • GC16P000264
  • GC16P000268
  • GC16P000283
  • GC16P000297

Summaries for HBQ1 Gene

Entrez Gene Summary for HBQ1 Gene

  • Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]

GeneCards Summary for HBQ1 Gene

HBQ1 (Hemoglobin, Theta 1) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is HBA2.

Gene Wiki entry for HBQ1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HBQ1 Gene

Genomics for HBQ1 Gene

Regulatory Elements for HBQ1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HBQ1 Gene

Start:
180,334 bp from pter
End:
181,181 bp from pter
Size:
848 bases
Orientation:
Plus strand

Genomic View for HBQ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HBQ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HBQ1 Gene

Proteins for HBQ1 Gene

  • Protein details for HBQ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09105-HBAT_HUMAN
    Recommended name:
    Hemoglobin subunit theta-1
    Protein Accession:
    P09105
    Secondary Accessions:
    • Q13723
    • Q1W6G5

    Protein attributes for HBQ1 Gene

    Size:
    142 amino acids
    Molecular mass:
    15508 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HBQ1 Gene

Proteomics data for HBQ1 Gene at MOPED

Post-translational modifications for HBQ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HBQ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HBQ1 Gene

Domains for HBQ1 Gene

Suggested Antigen Peptide Sequences for HBQ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09105

UniProtKB/Swiss-Prot:

HBAT_HUMAN :
  • P09105
Family:
  • Belongs to the globin family.
genes like me logo Genes that share domains with HBQ1: view

No data available for Gene Families for HBQ1 Gene

Function for HBQ1 Gene

Molecular function for HBQ1 Gene

GENATLAS Biochemistry:
hemoglobin,theta 1,embryonic

Gene Ontology (GO) - Molecular Function for HBQ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005344 oxygen transporter activity IEA --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0019825 oxygen binding IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with HBQ1: view

Phenotypes for HBQ1 Gene

genes like me logo Genes that share phenotypes with HBQ1: view

miRNA for HBQ1 Gene

miRTarBase miRNAs that target HBQ1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HBQ1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HBQ1 Gene

Localization for HBQ1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HBQ1 Gene COMPARTMENTS Subcellular localization image for HBQ1 gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HBQ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005833 hemoglobin complex IEA --
genes like me logo Genes that share ontologies with HBQ1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HBQ1 Gene

Pathways for HBQ1 Gene

SuperPathways for HBQ1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HBQ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015671 oxygen transport IEA --
genes like me logo Genes that share ontologies with HBQ1: view

No data available for Pathways by source for HBQ1 Gene

Compounds for HBQ1 Gene

(1) HMDB Compounds for HBQ1 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
genes like me logo Genes that share compounds with HBQ1: view

Transcripts for HBQ1 Gene

mRNA/cDNA for HBQ1 Gene

(10) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HBQ1 Gene

Hemoglobin, theta 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HBQ1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HBQ1 Gene

No ASD Table

Relevant External Links for HBQ1 Gene

GeneLoc Exon Structure for
HBQ1
ECgene alternative splicing isoforms for
HBQ1

Expression for HBQ1 Gene

mRNA expression in normal human tissues for HBQ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HBQ1 Gene

This gene is overexpressed in Whole Blood (43.5).

Protein differential expression in normal tissues for HBQ1 Gene

This gene is overexpressed in Fetal Liver (18.2), Cervix (11.6), Fetal Brain (8.2), and Thyroid (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HBQ1 Gene

SOURCE GeneReport for Unigene cluster for HBQ1 Gene Hs.247921

genes like me logo Genes that share expressions with HBQ1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for HBQ1 Gene

Orthologs for HBQ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HBQ1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HBQ1 35
  • 80.54 (n)
  • 74.45 (a)
HBQ1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hbq1b 35
  • 75.35 (n)
  • 75.35 (a)
Hbq1a 16
Hbq1a 36
  • 66 (a)
OneToMany
Hbq1b 36
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hbq1b 35
  • 74.65 (n)
  • 77.46 (a)
oppossum
(Monodelphis domestica)
Mammalia HBA 36
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HBAA 36
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii HBQ1 36
  • 41 (a)
OneToMany
Species with no ortholog for HBQ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HBQ1 Gene

ENSEMBL:
Gene Tree for HBQ1 (if available)
TreeFam:
Gene Tree for HBQ1 (if available)

Paralogs for HBQ1 Gene

Paralogs for HBQ1 Gene

Selected SIMAP similar genes for HBQ1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HBQ1: view

Variants for HBQ1 Gene

Sequence variations from dbSNP and Humsavar for HBQ1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs743861 -- 180,975(+) CTCGC(C/T)GCAGC intron-variant
rs1005364 -- 180,482(+) CAGCG(C/G/T)GGGGA utr-variant-5-prime
rs1203834 -- 181,542(-) CCCCG(A/G)GCCCT downstream-variant-500B
rs3888374 -- 181,551(+) GGCTG(A/G)CTCGG downstream-variant-500B
rs3888816 -- 180,928(+) GGTGC(C/G)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HBQ1 Gene

Variant ID Type Subtype PubMed ID
dgv2455n71 CNV Loss 21882294
esv2422427 CNV Duplication 17116639
nsv518291 CNV Loss 19592680
dgv2458n71 CNV Loss 21882294
nsv904637 CNV Loss 21882294
nsv827473 CNV Gain 20364138
dgv2460n71 CNV Loss 21882294
dgv2461n71 CNV Loss 21882294
nsv904652 CNV Loss 21882294
esv2662940 CNV Deletion 23128226
dgv2462n71 CNV Loss 21882294
nsv1698 CNV Loss 18451855
nsv904660 CNV Loss 21882294
dgv2464n71 CNV Loss 21882294
nsv519528 CNV Loss 19592680

Relevant External Links for HBQ1 Gene

HapMap Linkage Disequilibrium report
HBQ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HBQ1 Gene

Disorders for HBQ1 Gene

(1) University of Copenhagen DISEASES for HBQ1 Gene

genes like me logo Genes that share disorders with HBQ1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for HBQ1 Gene

Publications for HBQ1 Gene

  1. Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters. (PMID: 2569721) Kim J.H. … Shen C.-K.J. (Nucleic Acids Res. 1989) 3 4
  2. A review of the molecular genetics of the human alpha-globin gene cluster. (PMID: 2649166) Higgs D.R. … Weatherall D.J. (Blood 1989) 2 3
  3. Nucleotide sequence of the human theta 1-globin gene. (PMID: 3408475) Gonzalez-Redondo J.M. … Huisman T.H.J. (Biochem. Genet. 1988) 3 4
  4. Structure and expression of the human theta 1 globin gene. (PMID: 3422341) Hsu S.-L. … Shen C.-K.J. (Nature 1988) 3 4
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4

Products for HBQ1 Gene

Sources for HBQ1 Gene

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