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HBQ1 Gene

protein-coding   GIFtS: 50
GCID: GC16P000297

Hemoglobin, Theta 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hemoglobin, Theta 11 2
Hemoglobin Theta-1 Chain2 3
Hemoglobin Subunit Theta-12
theta-1-globin2
Theta-1-globin3

External Ids:    HGNC: 48331   Entrez Gene: 30492   Ensembl: ENSG000000865067   OMIM: 1422405   UniProtKB: P091053   

Export aliases for HBQ1 gene to outside databases

Previous GC identifers: GC16P000249 GC16P000170 GC16P000245 GC16P000149 GC16P000254 GC16P000256 GC16P000260 GC16P000264 GC16P000268 GC16P000283


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HBQ1 Gene:
Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid
tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1
is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The
order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'.
Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific
cells, possibly those of early erythroid tissue. (provided by RefSeq, Jul 2008)

GeneCards Summary for HBQ1 Gene:
HBQ1 (hemoglobin, theta 1) is a protein-coding gene. Diseases associated with HBQ1 include alpha thalassemia, and hemoglobinopathy. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is HBE1.

Gene Wiki entry for HBQ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the HBQ1 gene promoter:
         STAT1   MAZR   AP-1   ATF-2   STAT1beta   HNF-4alpha2   LCR-F1   STAT1alpha   HNF-4alpha1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHBQ1 promoter sequence
   Search Chromatin IP Primers for HBQ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HBQ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

HBQ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HBQ1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000297:  view genomic region     (about GC identifiers)

Start:
230,333 bp from pter      End:
231,180 bp from pter
Size:
848 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HBAT_HUMAN, P09105 (See protein sequence)
Recommended Name: Hemoglobin subunit theta-1  
Size: 142 amino acids; 15508 Da
Secondary accessions: Q13723 Q1W6G5

Explore the universe of human proteins at neXtProt for HBQ1: NX_P09105

Explore proteomics data for HBQ1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HBQ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005322.1  
    ENSEMBL proteins: 
     ENSP00000199708  

    HBQ1 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for HBQ1

    HBQ1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR002339 Haemoglobin_pi
     IPR012292 Globin_dom
     IPR002338 Haemoglobin_a
     IPR009050 Globin-like
     IPR000971 Globin

    Graphical View of Domain Structure for InterPro Entry P09105

    ProtoNet protein and cluster: P09105

    2 Blocks protein domains:
    IPB002338 Alpha haemoglobin signature
    IPB002339 Pi haemoglobin signature


    UniProtKB/Swiss-Prot: HBAT_HUMAN, P09105
    Similarity: Belongs to the globin family


    HBQ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for HBQ1:
    hemoglobin,theta 1,embryonic

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005344oxygen transporter activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0019825oxygen binding IEA--
    GO:0020037heme binding IEA--
         
    HBQ1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HBQ1:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HBQ1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HBQ1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HBQ1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HBQ1:
    hsa-mir-24-3p (MIRT030385)

    Block miRNA regulation of human, mouse, rat HBQ1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HBQ1:
    hsa-miR-888
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HBQ1

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    GenScript: all cDNA clones in your preferred vector: HBQ1 (NM_005331)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HBQ1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005833hemoglobin complex IEA--

    HBQ1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HBQ1
    Interactions:

        Search GeneGlobe Interaction Network for HBQ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for HBQ1 (ENSP000001997084) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AHSPENSP000003071994STRING: ENSP00000307199
    CYB5R3ENSP000003384614STRING: ENSP00000338461
    HBA1ENSP000003224214STRING: ENSP00000322421
    HBA2ENSP000002515954STRING: ENSP00000251595
    HBBENSP000003339944STRING: ENSP00000333994
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015671oxygen transport TAS7555018

    HBQ1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HBQ1 (HBAT)

    1 HMDB Compound for HBQ1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HBQ1 gene: 
    NM_005331.4  

    Unigene Cluster for HBQ1:

    Hemoglobin, theta 1
    Hs.247921  [show with all ESTs]
    Unigene Representative Sequence: BM479599
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000199708(uc002cfz.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HBQ1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HBQ1:
    hsa-miR-888
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HBQ1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HBQ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HBQ1
    Primer
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    OriGene qPCR primer pairs and template standards for HBQ1
    OriGene qSTAR qPCR primer pairs in human, mouse for HBQ1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HBQ1
      QuantiTect SYBR Green Assays in human, mouse, rat HBQ1
      QuantiFast Probe-based Assays in human, mouse, rat HBQ1

    Additional mRNA sequence: BC056686.1 

    1 DOTS entry:

    DT.424549 

    10 AceView cDNA sequences:

    NM_005331 BG944234 BC056686 BU602381 BM479599 AA643205 BU599657 CD580449 
    AA679786 AA860203 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HBQ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HBQ1 Expression
    About this image


    HBQ1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
    HBQ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HBQ1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247921
        Custom PCR Arrays for HBQ1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HBQ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HBQ1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hbq1a5
    Hbq1b1
    hemoglobin, theta 1A5
    hemoglobin, theta 1B1
    75.35(n)1
    75.35(a)1
      11 (18.87 cM)5
    5447631  NM_001033981.31  NP_001029153.11 
     323000695 
    chicken
    (Gallus gallus)
    Aves HBAA6
    Gallus gallus hemoglobin, alpha 1 (HBAA), mRNA.
    49(a)
    1 → many
    AADN03010595.1(5125-5931)
    zebrafish
    (Danio rerio)
    Actinopterygii HBQ16
    hemoglobin, theta 1
    41(a)
    1 → many
    12(21688563-21689767) ENSDARG00000045144


    ENSEMBL Gene Tree for HBQ1 (if available)
    TreeFam Gene Tree for HBQ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HBQ1 gene
    HBE12  HBG22  HBZ2  HBG12  HBD2  HBA22  HBB2  HBA12  
    HBM2  
    10 SIMAP similar genes for HBQ1 using alignment to 1 protein entry:     HBAT_HUMAN:
    HBA2    HBA1    HBZ    HBM    HBG2    HBG1
    HBE1    HBD    HBB    CYGB

    HBQ1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HBQ1 (see all 89)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1393853801,2
    --228414(+) CAGGCC/TCTCTG 1 -- us2k10--------
    rs1142552391,2
    C,F--228478(+) GAAGAC/TGGTGT 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs740006971,2
    C,F--228570(+) TGCAGC/TGCTTT 1 -- us2k12Minor allele frequency- T:0.04WA 120
    rs1873724361,2
    --228593(+) GATCAG/TAACCA 1 -- us2k10--------
    rs1430682861,2
    --228747(+) GTCAGA/GGGTTC 1 -- us2k10--------
    rs80580161,2
    C--228786(+) cctgtA/Ctctac 1 -- us2k10--------
    rs1923845411,2
    --228836(+) TGTAAA/GCCTGG 1 -- us2k10--------
    rs1857380461,2
    --228886(+) CCATCA/GCACTC 1 -- us2k10--------
    rs1400339371,2
    C--228917(+) AAACTC/GTGTCT 1 -- us2k10--------
    rs2006977791,2
    C--228939(+) TAATC-/TAATT 
            
    TAATT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HBQ1 (230333 - 231180 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HBQ1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662940CNV Deletion23128226
    esv2422427CNV Duplication17116639
    dgv2462n71CNV Loss21882294
    nsv519528CNV Loss19592680
    dgv2461n71CNV Loss21882294
    nsv904660CNV Loss21882294
    nsv1698CNV Loss18451855
    dgv2458n71CNV Loss21882294
    dgv2464n71CNV Loss21882294
    dgv2460n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HBQ1
    DNA2.0 Custom Variant and Variant Library Synthesis for HBQ1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142240    OMIM disorders: --

    3 diseases for HBQ1:    
    About MalaCards
    alpha thalassemia    hemoglobinopathy    thalassemia

    1 disease from the University of Copenhagen DISEASES database for HBQ1:
    Alpha thalassemia

    HBQ1 for disorders           About GeneDecksing


    Export disorders for HBQ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HBQ1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with HBQ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. (PubMed id 16728641)1, 2 De Gobbi M.... Higgs D.R. (Science 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    4. Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters. (PubMed id 2569721)1, 2 Kim J.H.... Shen C.-K.J. (Nucleic Acids Res. 1989)
    5. A review of the molecular genetics of the human alpha-globin gene cluster. (PubMed id 2649166)1, 3 Higgs D.R....Weatherall D.J. (Blood 1989)
    6. Nucleotide sequence of the human theta 1-globin gene. (PubMed id 3408475)1, 2 Gonzalez-Redondo J.M.... Huisman T.H.J. (Biochem. Genet. 1988)
    7. Structure and expression of the human theta 1 globin gene. (PubMed id 3422341)1, 2 Hsu S.-L....Shen C.-K.J. (Nature 1988)
    8. [Molecular characterization of two new mutations of I+A^ thalassemia in two Spanish families (mutation --(ED) and --(GP))]. (PubMed id 21453942)1 Villegas A....AtaA_lfo GonzA!lez F. (Med Clin (Barc) 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Molecular diagnosis of inherited disorders: lessons from hemoglobinopathies. (PubMed id 16138310)1 Patrinos G.P....Papadakis M.N. (Hum. Mutat. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3049 HGNC: 4833 AceView: HBQ1 Ensembl:ENSG00000086506 euGenes: HUgn3049
    ECgene: HBQ1 H-InvDB: HBQ1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HBQ1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HBQ1 gene:
    Search GeneIP for patents involving HBQ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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