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Aliases for HBP1 Gene

Aliases for HBP1 Gene

  • HMG-Box Transcription Factor 1 2 3 5
  • High Mobility Group Box Transcription Factor 1 4
  • HMG Box Transcription Factor 1 4

External Ids for HBP1 Gene

Previous GeneCards Identifiers for HBP1 Gene

  • GC07P105293
  • GC07P106356
  • GC07P106369
  • GC07P106403
  • GC07P106596
  • GC07P106809
  • GC07P101170

Summaries for HBP1 Gene

GeneCards Summary for HBP1 Gene

HBP1 (HMG-Box Transcription Factor 1) is a Protein Coding gene. Among its related pathways are Signaling mediated by p38-alpha and p38-beta and E2F transcription factor network. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for HBP1 Gene

  • Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5-TTCATTCATTCA-3. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

Gene Wiki entry for HBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HBP1 Gene

Genomics for HBP1 Gene

Regulatory Elements for HBP1 Gene

Enhancers for HBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F107166 0.8 ENCODE 43.5 +0.2 216 5.6 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 HBP1 COG5 ENSG00000272072 LAMB1 CBLL1 PRKAR2B
GH07F107742 0.2 ENCODE 41.1 +575.5 575539 4.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 HBP1 RPL7P32 ENSG00000272072 LOC101927974 COG5 LAMB1 CBLL1 PIK3CG SLC26A4 SLC26A4-AS1
GH07F108102 0.2 ENCODE 41.1 +935.1 935096 2.4 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 HBP1 ENSG00000272072 RPL7P32 LAMB1 COG5 CBLL1 PIR53493 LAMB4
GH07F107044 0.9 FANTOM5 Ensembl ENCODE 26.5 -122.3 -122341 5.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 CBX5 REST HBP1 ENSG00000272072 CBLL1 COG5 PRKAR2B GPR22 GC07M107108
GH07F106281 0.4 ENCODE 26.4 -884.7 -884722 4.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 HBP1 RINT1 ENSG00000272072 RWDD4P1 NAMPT GC07M106278 RNU6-392P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HBP1 on UCSC Golden Path with GeneCards custom track

Promoters for HBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000312408 -60 4200 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21

Genomic Location for HBP1 Gene

Chromosome:
7
Start:
107,168,961 bp from pter
End:
107,202,529 bp from pter
Size:
33,569 bases
Orientation:
Plus strand

Genomic View for HBP1 Gene

Genes around HBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HBP1 Gene

Proteins for HBP1 Gene

  • Protein details for HBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60381-HBP1_HUMAN
    Recommended name:
    HMG box-containing protein 1
    Protein Accession:
    O60381
    Secondary Accessions:
    • B3KVB7
    • Q8TBM1
    • Q8TE93
    • Q96AJ2

    Protein attributes for HBP1 Gene

    Size:
    514 amino acids
    Molecular mass:
    57645 Da
    Quaternary structure:
    • Binds the second PAH repeat of SIN3A (By similarity). Binds TCF4 and RB1.
    SequenceCaution:
    • Sequence=BAB85059.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HBP1 Gene

    Alternative splice isoforms for HBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HBP1 Gene

Post-translational modifications for HBP1 Gene

  • Ubiquitination at Lys 16 and Lys 398
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HBP1 Gene

Domains & Families for HBP1 Gene

Protein Domains for HBP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60381

UniProtKB/Swiss-Prot:

HBP1_HUMAN :
  • Contains 1 AXH domain.
Domain:
  • Contains 1 AXH domain.
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with HBP1: view

No data available for Gene Families for HBP1 Gene

Function for HBP1 Gene

Molecular function for HBP1 Gene

GENATLAS Biochemistry:
histone hairpin binding protein 1,31kDa,involved in replication-dependent histone gene expression
UniProtKB/Swiss-Prot Function:
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5-TTCATTCATTCA-3. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

Gene Ontology (GO) - Molecular Function for HBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 23859194
genes like me logo Genes that share ontologies with HBP1: view
genes like me logo Genes that share phenotypes with HBP1: view

Animal Model Products

miRNA for HBP1 Gene

miRTarBase miRNAs that target HBP1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HBP1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HBP1 Gene

Localization for HBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HBP1 Gene COMPARTMENTS Subcellular localization image for HBP1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for HBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with HBP1: view

Pathways & Interactions for HBP1 Gene

genes like me logo Genes that share pathways with HBP1: view

SIGNOR curated interactions for HBP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007050 cell cycle arrest NAS 9030690
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with HBP1: view

Transcripts for HBP1 Gene

Unigene Clusters for HBP1 Gene

HMG-box transcription factor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HBP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HBP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^
SP1: - -
SP2: - - - - - - -
SP3: -
SP4: -
SP5: - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - -
SP8: - - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - - -
SP12:
SP13:

ExUns: 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for HBP1 Gene

GeneLoc Exon Structure for
HBP1
ECgene alternative splicing isoforms for
HBP1

Expression for HBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HBP1 Gene

This gene is overexpressed in Pancreatic juice (27.0), Urine (25.5), and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HBP1 Gene



Protein tissue co-expression partners for HBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HBP1 Gene:

HBP1

SOURCE GeneReport for Unigene cluster for HBP1 Gene:

Hs.162032
genes like me logo Genes that share expression patterns with HBP1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HBP1 Gene

Orthologs for HBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HBP1 34 35
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia HBP1 34 35
  • 94.19 (n)
cow
(Bos Taurus)
Mammalia HBP1 34 35
  • 92.78 (n)
mouse
(Mus musculus)
Mammalia Hbp1 34 16 35
  • 92.37 (n)
rat
(Rattus norvegicus)
Mammalia Hbp1 34
  • 90.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HBP1 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HBP1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves HBP1 34 35
  • 81.41 (n)
lizard
(Anolis carolinensis)
Reptilia HBP1 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hbp1 34
  • 75.98 (n)
Str.1878 34
African clawed frog
(Xenopus laevis)
Amphibia hbp1-A 34
zebrafish
(Danio rerio)
Actinopterygii hbp1 34 35
  • 66.6 (n)
Species where no ortholog for HBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HBP1 Gene

ENSEMBL:
Gene Tree for HBP1 (if available)
TreeFam:
Gene Tree for HBP1 (if available)

Paralogs for HBP1 Gene

genes like me logo Genes that share paralogs with HBP1: view

No data available for Paralogs for HBP1 Gene

Variants for HBP1 Gene

Sequence variations from dbSNP and Humsavar for HBP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1002935 -- 107,191,916(-) AGTCA(C/T)AGCCA intron-variant
rs10237356 -- 107,195,096(+) gtgca(G/T)tgctg intron-variant
rs10245000 -- 107,193,508(+) TGTTC(C/T)TTTTG intron-variant
rs10255924 -- 107,180,154(+) GGCTA(A/G)AAAGG intron-variant
rs10275036 -- 107,167,187(+) TAGCA(A/G)AGACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HBP1 Gene

Variant ID Type Subtype PubMed ID
esv3614455 CNV loss 21293372
nsv831087 CNV gain 17160897

Variation tolerance for HBP1 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HBP1 Gene

Disorders for HBP1 Gene

Relevant External Links for HBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HBP1

No disorders were found for HBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HBP1 Gene

Publications for HBP1 Gene

  1. Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. (PMID: 11500377) Sampson E.M. … Yee A.S. (EMBO J. 2001) 2 3 4 22 64
  2. Human HMG box transcription factor HBP1: a role in hCD2 LCR function. (PMID: 10562551) Zhuma T. … Kioussis D. (EMBO J. 1999) 3 4 22 64
  3. HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. (PMID: 9030690) Tevosian S.G. … Yee A.S. (Genes Dev. 1997) 2 3 22 64
  4. Macrophage migration inhibitory factor is a direct target of HBP1-mediated transcriptional repression that is overexpressed in prostate cancer. (PMID: 20383199) Chen Y.C. … Mao Z.B. (Oncogene 2010) 3 22 64
  5. Alterations of the HBP1 transcriptional repressor are associated with invasive breast cancer. (PMID: 17616670) Paulson K.E. … Yee A.S. (Cancer Res. 2007) 3 22 64

Products for HBP1 Gene

Sources for HBP1 Gene

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