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Aliases & Descriptions for HBP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| HMG box transcription factor 1 3 | | HMG-box containing protein 1 2 | | HMG-box transcription factor 1 2 | | High mobility group box transcription factor 1 3 |
|
| | Search outside databases for aliases for HBP1 genePrevious GC identifers: GC07P105293 GC07P106356 GC07P106369 GC07P106403 |
Summaries for HBP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: HBP1_HUMAN, O60381Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4Gene Wiki entry for HBP1 |
Genomic Location for HBP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HBP1 gene 
Entrez Gene cytogenetic band: 7q22-q31 Ensembl cytogenetic band: 7q22.3 HGNC cytogenetic band: 7q22-q31HBP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P106596:
(about GC identifiers)
Start:
|
106,596,696 bp from pter |
End:
|
106,630,210 bp from pter |
Size:
|
33,515 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 106,170,547-106,204,061 |
RefSeq DNA sequence:- NC_000007.12 NT_007933.14 NT_079596.2
| Proteins for HBP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HBP1_HUMAN, O60381 (See
protein sequence)Recommended Name: HMG box-containing protein 1 Size: 514 amino acids; 57645 Da
Subunit: Binds the second PAH repeat of SIN3A (By similarity). Binds TCF4 and RB1
Subcellular location: Nucleus
PDB structures from and Proteopedia :2E6O (3D)
 
Secondary accessions: Q8TBM1 Q8TE93 Q96AJ2Alternative splicing: 3 isoforms: O60381-1 O60381-2 O60381-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_036389.2
ENSEMBL proteins: ENSP00000222574
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for HBP1: Assays for HBP1: | Protein
Domains/ Families for HBP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O60381
ProtoNet protein and cluster: O60381 UniProtKB/Swiss-Prot: HBP1_HUMAN, O60381Similarity: Contains 1 AXH domainSimilarity: Contains 1 HMG box DNA-binding domain | Gene Function for HBP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012257
Applied Biosystems Silencer® siRNAs for HBP1
Sigma-Aldrich siRNA for HBP1  Sigma-Aldrich shRNA for HBP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012257                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012257                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012257 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012257
UniProtKB/Swiss-Prot: HBP1_HUMAN, O60381Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4Genatlas biochemistry entry for HBP1:histone hairpin binding protein 1,31kDa,involved in replication-dependent histone gene expression2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for HBP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for HBP1 
5/21 Interacting proteins for HBP1 (ENSP000002225743 O603812) via UniProtKB, MINT, and/or STRING (see all 21
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for HBP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for HBP1
|
Transcripts for HBP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012257
Sigma-Aldrich siRNA for HBP1  Sigma-Aldrich shRNA for HBP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012257 REFSEQ mRNAs for HBP1 gene: NM_012257.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012257               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012257                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012257                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012257  Additional cDNA sequence: AF019214.1 AF182038.1 AK025284.1 AK074353.1 AK122785.1 AK295910.1 AK298504.1 BC017069.1 BC022329.2 CR590649.1 CR594009.1 CR617831.1 23 DOTS entries: DT.95112747 DT.427564 DT.95309090 DT.102836928 DT.121103104 DT.100877367 DT.92465934 DT.438484 DT.92465940 DT.121102998 DT.92465944 DT.121102986 DT.97805124 DT.121103107 DT.121103149 DT.100877357 DT.121102966 DT.121103102 DT.121103160 DT.70104055 DT.100877360 DT.100877362 DT.100877364 24/322 AceView cDNA sequences (see all 322
):AI921617 BX492885 AI283762 BU162581 CB160834 AI767400 AI540600 CB159450 BI754442 CA390939 AI274188 BU194447 T05989 BQ002066 BM919651 AF182038 CR617831 BX501460 AI003668 CA414822 BQ182845 BF940134 AA680013 CN482516
highest scoring ESTs for HBP1:AF019214 AA013007 AA411933 AA449940 AA468574 AA489167 AA576005 AA576368 AA609324 AA648903 Unigene Cluster for HBP1: HMG-box transcription factor 1 Hs.162032 [show with all ESTs]Unigene Representative Sequence: NM_012257
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for HBP1 (see all 13
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP5: | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14a | · | 14b | |
| SP1: | |   | |   | - |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for HBP1
1 Ensembl transcript including schematic representation: ENST00000222574
|
Expression for HBP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HBP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HBP1
1 / 2 / 3 6 probe-sets matching HBP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATGTTGCCCC
SOURCE GeneReport for Unigene cluster: Hs.162032
Expression variation in blood from EXPOLDB for HBP1 |
Orthologs for HBP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HBP1 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for HBP1
ENSEMBL Gene Tree for HBP1 | Paralogs for HBP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for HBP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HBP1 (up to first 250kb)
|
Disorders & Mutations for HBP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| 2 Novoseek disease relationships for HBP1 gene
About this table
|
Medical News for HBP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HBP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/29 PubMed articles for HBP1 gene (see all 29
):- Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. (PubMed id 11500377)1, 2, 3, 4 Sampson E.M....Yee A.S. (2001)
- HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. (PubMed id 9030690)1, 2, 3 Tevosian S.G....Yee A.S. (1997)
- Human HMG box transcription factor HBP1: a role in hCD2 LCR function. (PubMed id 10562551)1, 3, 4 Zhuma T....Kioussis D. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression. (PubMed id 10958660)3, 4 Lemercier C.... Khochbin S. (2000)
- Alterations of the HBP1 transcriptional repressor are associated with invasive breast cancer. (PubMed id 17616670)1, 3 Paulson K.E....Yee A.S. (2007)
- Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells. (PubMed id 16179914)1, 3 Yao C.J.... Austin G.E. (2005)
- HBP1 repression of the p47phox gene: cell cycle regulation via the NADPH oxidase. (PubMed id 15024088)1, 3 Berasi S.P....Paulson K.E. (2004)
|
Search for HBP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HBP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HBP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HBP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HBP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HBP1:

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Incremental update: 13 Oct 2009
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