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HBP1 Gene

protein-coding   GIFtS: 58
GCID: GC07P106809

HMG-Box Transcription Factor 1

  See HBP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HMG-Box Transcription Factor 11 2
High Mobility Group Box Transcription Factor 12 3
HMG Box Transcription Factor 12 3
HMG Box-Containing Protein 12
USMCC25

External Ids:    HGNC: 232001   Entrez Gene: 269592   Ensembl: ENSG000001058567   OMIM: 6118105   UniProtKB: O603813   

Export aliases for HBP1 gene to outside databases

Previous GC identifers: GC07P105293 GC07P106356 GC07P106369 GC07P106403 GC07P106596 GC07P101170


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HBP1 Gene:
HBP1 (HMG-box transcription factor 1) is a protein-coding gene. Diseases associated with HBP1 include ureter cancer. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: HBP1_HUMAN, O60381
Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the
regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'.
Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4

Gene Wiki entry for HBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HBP1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): HBP1 promoter sequence
   Search Chromatin IP Primers for HBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22-q31   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22-q31

HBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HBP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P106809:  view genomic region     (about GC identifiers)

Start:
106,809,406 bp from pter      End:
106,842,974 bp from pter
Size:
33,569 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 106,170,547-106,204,061     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HBP1_HUMAN, O60381 (See protein sequence)
Recommended Name: HMG box-containing protein 1  
Size: 514 amino acids; 57645 Da
Subunit: Binds the second PAH repeat of SIN3A (By similarity). Binds TCF4 and RB1
Sequence caution: Sequence=BAB85059.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for HBP1:
2E6O (3D)        3QVE (3D)    
Secondary accessions: B3KVB7 Q8TBM1 Q8TE93 Q96AJ2
Alternative splicing: 3 isoforms:  O60381-1   O60381-2   O60381-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HBP1: NX_O60381

Explore proteomics data for HBP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys16, Lys398
  • Modification sites at PhosphoSitePlus

  • See HBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231191.1  NP_036389.2  

    ENSEMBL proteins: 
     ENSP00000420500   ENSP00000418022   ENSP00000420137   ENSP00000222574   ENSP00000420281  
     ENSP00000417631   ENSP00000418738   ENSP00000417927   ENSP00000418017   ENSP00000475809  
     ENSP00000419143  

    HBP1 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for HBP1
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    Cloud-Clone Corp. Proteins for HBP1

     
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    antibodies-online proteins for HBP1 (5 products) 

     
    antibodies-online peptides for HBP1

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    antibodies-online kits for HBP1 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013723 Ataxin-1_HBP1
     IPR003652 Ataxin_AXH_dom
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry O60381

    ProtoNet protein and cluster: O60381

    UniProtKB/Swiss-Prot: HBP1_HUMAN, O60381
    Similarity: Contains 1 AXH domain
    Similarity: Contains 1 HMG box DNA-binding domain


    Find genes that share domains with HBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HBP1_HUMAN, O60381
    Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the
    regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'.
    Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4

         Genatlas biochemistry entry for HBP1:
    histone hairpin binding protein 1,31kDa,involved in replication-dependent histone gene expression

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with HBP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HBP1:
     Increased cell death in breast 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hbp1):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 

    Find genes that share phenotypes with HBP1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HBP1

    miRNA
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    miRTarBase miRNAs that target HBP1:
    hsa-mir-17-5p (MIRT031371), hsa-mir-155-5p (MIRT020927), hsa-mir-335-5p (MIRT018624), hsa-mir-29a-3p (MIRT035539), hsa-mir-19b-3p (MIRT031302), hsa-mir-17-3p (MIRT050750)

    Block miRNA regulation of human, mouse, rat HBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HBP1 (see all 50):
    hsa-miR-300 hsa-miR-106a hsa-miR-29a hsa-miR-301a hsa-miR-519a hsa-miR-508-3p hsa-miR-124 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidHBP1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for HBP1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HBP1_HUMAN, O60381: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with HBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling mediated by p38-alpha and p38-beta
    Signaling mediated by p38-alpha and p38-beta
    2Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    3E2F transcription factor network
    E2F transcription factor network
    4C-MYC pathway
    C-MYC pathway


    4 BioSystems Pathways for HBP1
        E2F transcription factor network
    Signaling mediated by p38-alpha and p38-beta
    C-MYC pathway
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HBP1
    Interactions:

        GeneGlobe Interaction Network for HBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HBP1 (O603811, 2, 3 ENSP000002225744) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRM1Q161862, 3, ENSP000002530034MINT-2869185 I2D: score=1 STRING: ENSP00000253003
    EFEMP2O959672, 3, ENSP000003099534MINT-2872699 I2D: score=1 STRING: ENSP00000309953
    GKAP1Q5VSY02, 3, ENSP000003655504MINT-2876688 I2D: score=1 STRING: ENSP00000365550
    SERPINI2O758302, 3, ENSP000002646774MINT-2861759 I2D: score=1 STRING: ENSP00000264677
    ZG16O608442, 3, ENSP000003835634MINT-2878488 I2D: score=1 STRING: ENSP00000383563
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007050cell cycle arrest NAS9030690
    GO:0016055Wnt signaling pathway IEA--
    GO:0043268positive regulation of potassium ion transport IEA--

    Find genes that share ontologies with HBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HBP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HBP1 gene (2 alternative transcripts): 
    NM_001244262.1  NM_012257.3  

    Unigene Cluster for HBP1:

    HMG-box transcription factor 1
    Hs.162032  [show with all ESTs]
    Unigene Representative Sequence: NM_012257
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468410(uc011klv.2) ENST00000478930 ENST00000464009 ENST00000222574(uc003vdy.3 uc003vdz.3)
    ENST00000468401 ENST00000468116 ENST00000497535 ENST00000485846 ENST00000479011
    ENST00000463202(uc003veb.1) ENST00000498408(uc003vea.3) ENST00000461963
    ENST00000483809 ENST00000607681 ENST00000463790
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HBP1 (see all 50):
    hsa-miR-300 hsa-miR-106a hsa-miR-29a hsa-miR-301a hsa-miR-519a hsa-miR-508-3p hsa-miR-124 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidHBP1 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat HBP1
      QuantiFast Probe-based Assays in human, mouse, rat HBP1

    Additional mRNA sequence: 

    AF019214.1 AF182038.1 AK025284.1 AK074353.1 AK122785.1 AK295910.1 AK298504.1 BC017069.1 
    BC022329.2 

    24 DOTS entries:

    DT.95112747  DT.427564  DT.102836928  DT.95309090  DT.100877367  DT.121103104  DT.92465934  DT.92465940 
    DT.121102998  DT.92465944  DT.121102986  DT.121103107  DT.121103149  DT.100877357  DT.121102966  DT.121103102 
    DT.121103160  DT.70104055  DT.97805124  DT.100877361  DT.100877362  DT.100877364  DT.438484  DT.95304157 

    Selected AceView cDNA sequences (see all 322):

    AI283762 AK122785 CR594009 CD743048 AU280613 AA488097 AA729310 BM472614 
    AU139528 BM919651 CB160834 BX501460 BM993467 AU127771 AI675962 BM843353 
    T05989 CD642208 AA343773 AA766707 CN482516 AL121293 AL548310 AI921617 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HBP1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^
    SP1:                                      -                                                                                                     -               
    SP2:                    -     -     -     -     -     -                                                                                         -               
    SP3:                                                                                                                                            -               
    SP4:                                                                                                                                            -               
    SP5:              -     -     -     -     -     -     -                                                                                                         

    ExUns: 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b
    SP1:              -           -               
    SP2:              -           -               
    SP3:              -                           
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for HBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTTGCCCC
    HBP1 Expression
    About this image


    HBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    HBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162032
        Custom PCR Arrays for HBP1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HBP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hbp11 , 5 high mobility group box transcription factor 11, 5 92.37(n)1
    95.23(a)1
      12 (13.73 cM)5
    733891  NM_153198.21  NP_694878.21 
     319262545 
    chicken
    (Gallus gallus)
    Aves HBP11 HMG-box transcription factor 1 81.41(n)
    84.15(a)
      417705  NM_001199454.2  NP_001186383.1 
    lizard
    (Anolis carolinensis)
    Reptilia HBP16
    HMG-box transcription factor 1
    81(a)
    1 ↔ 1
    5(97271211-97286042)
    African clawed frog
    (Xenopus laevis)
    Amphibia hbp1-A2 HMG-box containing protein 1 81.36(n)    AF530514.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hbp11 HMG-box transcription factor 1 66.6(n)
    67.96(a)
      554137  NM_001024431.2  NP_001019602.2 


    ENSEMBL Gene Tree for HBP1 (if available)
    TreeFam Gene Tree for HBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HBP1 gene
    17 SIMAP similar genes for HBP1 using alignment to 9 protein entries:     HBP1_HUMAN (see all proteins):
    SUMO1    LSM12    SEPSECS    TM2D1    NAE1    VPS33A
    COQ5    FLJ00047    SIPA1L3    TUBA1C    ARIH1    TNNT1
    DPP9    EIF3G    CIC    IRF5    ASCC1

    Find genes that share paralogs with HBP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HBP1 (see all 498)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs350626271,2
    C--106807411(+) AGCTC-/TTTTTT 1 -- us2k10--------
    rs2573851,2
    C,F--106807448(+) TTAGTT/CTTCTA 1 -- us2k11Minor allele frequency- C:0.21NA 120
    rs680645691,2
    C--106807653(+) TGAGTC/AACTAA 2 -- us2k13Minor allele frequency- A:0.06WA NA 240
    rs2573861,2
    C,F--106807783(+) GTGAAC/GATAGA 2 -- us2k15Minor allele frequency- G:0.16NA 250
    rs1416977781,2
    --106807785(+) GAACAC/TAGAAA 2 -- us2k10--------
    rs1129879471,2
    C,F--106807935(+) GTATAT/CTTAAA 2 -- us2k12Minor allele frequency- C:0.06CSA WA 120
    rs9576671,2
    C,H--106807968(-) TATTTC/TTTTAA 2 -- us2k1 tfbs37Minor allele frequency- T:0.00NA EA NS 666
    rs1505423531,2
    --106808029(+) CTTACA/TAATGT 2 -- us2k10--------
    rs1388749651,2
    --106808136(+) GGGGGA/GAAAAG 2 -- us2k10--------
    rs612636381,2
    C--106816202(+) TCGCC-/CAGGCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for HBP1 (106809406 - 106842974 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831087CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for HBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611810    OMIM disorders: --

    1 disease for HBP1:    
    About MalaCards
    ureter cancer

    1 disease from the University of Copenhagen DISEASES database for HBP1:
    Ureter cancer

    Find genes that share disorders with HBP1           About GenesLikeMe

    2 Novoseek inferred disease relationships for HBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 36.3 2 9030690 (1), 10030670 (1)
    tumors 5.38 8 19223422 (2), 15225871 (2), 20383199 (2), 16179914 (1)


    Export disorders for HBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HBP1 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with HBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. (PubMed id 11500377)1, 2, 3, 9 Sampson E.M.... Yee A.S. (EMBO J. 2001)
    2. HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. (PubMed id 9030690)1, 3, 9 Tevosian S.G....Yee A.S. (amp 1997)
    3. Human HMG box transcription factor HBP1: a role in hCD2 LCR function. (PubMed id 10562551)1, 2, 9 Zhuma T....Kioussis D. (EMBO J. 1999)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression. (PubMed id 10958660)1, 2 Lemercier C.... Khochbin S. (Mol. Cell. Biol. 2000)
    8. Alterations of the HBP1 transcriptional repressor are associated with invasive breast cancer. (PubMed id 17616670)1, 9 Paulson K.E....Yee A.S. (Cancer Res. 2007)
    9. Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells. (PubMed id 16179914)1, 9 Yao C.J.... Austin G.E. (Leukemia 2005)
    10. HBP1 repression of the p47phox gene: cell cycle regulation via the NADPH oxidase. (PubMed id 15024088)1, 9 Berasi S.P....Paulson K.E. (Mol. Cell. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26959 HGNC: 23200 AceView: HBP1 Ensembl:ENSG00000105856 euGenes: HUgn26959
    ECgene: HBP1 H-InvDB: HBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HBP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HBP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HBP1 gene:
    Search GeneIP for patents involving HBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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