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HBP1 Gene

protein-coding   GIFtS: 57

GC07P106596
HMG-box transcription factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ16340 2
Descriptions
HMG box transcription factor 1 3
HMG-box containing protein 1 2
HMG-box transcription factor 1 2
High mobility group box transcription factor 1 3
External Ids
HGNC: 232001
Entrez Gene: 269592
UniProtKB: O603813
Ensembl: ENSG000001058567
Search outside databases for aliases for HBP1 gene

Previous GC identifers: GC07P105293 GC07P106356 GC07P106369 GC07P106403

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: HBP1_HUMAN, O60381
Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role
in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence
5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the
interaction between DNA and TCF4

Gene Wiki entry for HBP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the HBP1 gene  

Entrez Gene cytogenetic band: 7q22-q31   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22-q31

HBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P106596:     (about GC identifiers)

Start:
106,596,696 bp from pter
End:
106,630,210 bp from pter
Size:
33,515 bases
Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 106,170,547-106,204,061     
RefSeq DNA sequence:
NC_000007.12  NT_007933.14  NT_079596.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: HBP1_HUMAN, O60381 (See protein sequence)
Recommended Name: HMG box-containing protein 1  
Size: 514 amino acids; 57645 Da
Subunit: Binds the second PAH repeat of SIN3A (By similarity). Binds TCF4 and RB1
Subcellular location: Nucleus
PDB structures from and Proteopedia :
2E6O (3D)    
Secondary accessions: Q8TBM1 Q8TE93 Q96AJ2
Alternative splicing: 3 isoforms:  O60381-1   O60381-2   O60381-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_036389.2  

    ENSEMBL proteins: 
    ENSP00000222574 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (HBP1)
    Human Recombinant Proteins from Abnova (HBP1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for HBP1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for HBP1
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    Antibodies from Abcam (HBP1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (HBP1)
    Novus Biologicals Antibodies for HBP1

    Assays for HBP1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR000910 HMG_HMG1/HMG2
     IPR013723 Ataxin-1_HBP1
     IPR003652 Ataxin_AXH


       GeneDecks  HBP1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O60381

    ProtoNet protein and cluster: O60381

    UniProtKB/Swiss-Prot: HBP1_HUMAN, O60381
    Similarity: Contains 1 AXH domain
    Similarity: Contains 1 HMG box DNA-binding domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (HBP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (HBP1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012257

                  Applied Biosystems Silencer® siRNAs for HBP1

                  Sigma-Aldrich siRNA for HBP1  
                         Sigma-Aldrich shRNA for HBP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for HBP1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_012257
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_012257
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_012257 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_012257

    UniProtKB/Swiss-Prot: HBP1_HUMAN, O60381
    Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role
    in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence
    5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the
    interaction between DNA and TCF4

    Genatlas biochemistry entry for HBP1:
    histone hairpin binding protein 1,31kDa,involved in replication-dependent histone gene expression

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0005515 protein binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  HBP1 


    5/21 Interacting proteins for HBP1 (ENSP000002225743 O603812) via UniProtKB, MINT, and/or STRING (see all 21 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRM1Q161862MINT-2869185
    EFEMP2O959672MINT-2872699
    ENSG00000215672O608442MINT-2878488
    EWSR1Q018442MINT-2858685
    FAM127AO152552MINT-2865593
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0007050 cell cycle arrest NAS9030690
    GO:0016055 Wnt receptor signaling pathway IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for HBP1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (HBP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (HBP1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012257

                  Sigma-Aldrich siRNA for HBP1  
                         Sigma-Aldrich shRNA for HBP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_012257  

    REFSEQ mRNAs for HBP1 gene: 

    NM_012257.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_012257  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_012257
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_012257
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_012257 

    Additional cDNA sequence: 

    AF019214.1 AF182038.1 AK025284.1 AK074353.1 AK122785.1 AK295910.1 AK298504.1 BC017069.1 
    BC022329.2 CR590649.1 CR594009.1 CR617831.1 

    23 DOTS entries:

    DT.95112747  DT.427564  DT.95309090  DT.102836928  DT.121103104  DT.100877367  DT.92465934  DT.438484 
    DT.92465940  DT.121102998  DT.92465944  DT.121102986  DT.97805124  DT.121103107  DT.121103149  DT.100877357 
    DT.121102966  DT.121103102  DT.121103160  DT.70104055  DT.100877360  DT.100877362  DT.100877364 

    24/322 AceView cDNA sequences (see all 322 ):

    AI921617 BX492885 AI283762 BU162581 CB160834 AI767400 AI540600 CB159450 
    BI754442 CA390939 AI274188 BU194447 T05989 BQ002066 BM919651 AF182038 
    CR617831 BX501460 AI003668 CA414822 BQ182845 BF940134 AA680013 CN482516 

    highest scoring ESTs for HBP1:

    AF019214 AA013007 AA411933 AA449940 AA468574 AA489167 AA576005 AA576368 AA609324 AA648903 

    Unigene Cluster for HBP1:

    HMG-box transcription factor 1
    Hs.162032  [show with all ESTs]
    Unigene Representative Sequence: NM_012257


    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for HBP1 (see all 13 )

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^
    SP1:                                      -                                                                                                     -               
    SP2:                    -     -     -     -     -     -                                                                                         -               
    SP3:                                                                                                                                            -               
    SP4:                                                                                                                                            -               
    SP5:              -     -     -     -     -     -     -                                                                                                         

    ExUns: 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b
    SP1:              -           -               
    SP2:              -           -               
    SP3:              -                           
    SP4:                                          
    SP5:                                          

    About this scheme

    ECgene alternative splicing isoforms for HBP1

    1 Ensembl transcript including schematic representation:
    ENST00000222574  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    HBP1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for HBP1

    1 / 2 / 3

    6 probe-sets matching HBP1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    39809_at2, 3 U95-A 1 1.00 1.00 0.89 1.11 AF019214 1.00 1.00 1.00 1

    87540_at2, 3 U95-E 1 0.56 1.00 0.66 0.89 AA560005 0.60 1.00 0.82 1

    209102_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF019214 1.00 1.00 1.00 1

    207361_at2, 3 U133-A 1 1.00 1.00 -- -- NM_012257 0.60 1.00 0.82 1

    209102_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    207361_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ATGTTGCCCC

    SOURCE GeneReport for Unigene cluster: Hs.162032

    Expression variation in blood from EXPOLDB for HBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for HBP1 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    HBP11   -- HMG-box transcription factor 1 94.21(n)
    96.87(a)
    475886  XM_843890.1  XP_848983.1 
    chimpanzee
    (Pan troglodytes)
    HBP11   -- HMG-box transcription factor 1 99.94(n)
    100(a)
    463650  XM_519304.2  XP_519304.2 
    cow
    (Bos taurus)
    HBP11   -- HMG-box transcription factor 1 92.71(n)
    94.73(a)
    515320  NM_001046196.1  NP_001039661.1 
    rat
    (Rattus norvegicus)
    Hbp11   -- HMG-box transcription factor 1 91.02(n)
    93.36(a)
    27080  NM_013221.1  NP_037353.1 
    mouse
    (Mus musculus)
    Hbp11, 5 125
    high mobility group box transcription factor 11, 5 92.28(n)1
    95.14(a)1
    733891  NM_153198.11  NP_694878.11 
     AA4381115  AI4651725  (see all 26)
    About this table        Species with no ortholog for HBP1

    ENSEMBL Gene Tree for HBP1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/118 NCBI SNPs in HBP1 are shown (see all 118 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 71)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs2573871,2
    A,C,F,H106595716(+) AAAATG/ACCGCT 1 -- ng5112Minor allele frequency- A:0.40NA PA NS EU EA WA 768
    rs2573861,2
    C,F106595019(+) GTGAAC/GATAGA 1 -- ng513Minor allele frequency- G:0.10NA 128
    rs9576671,2
    H106595204(-) TATTTC/TTTTAA 1 -- ng51 tfbs37Minor allele frequency- T:0.00NA EA EU WA 666
    rs47302201,2
    F106596292(+) TCCCTA/GTGACT 1 -- ng511Minor allele frequency- G:0.32EA 200
    rs77945981,2
    A,C,F,H106613617(+) AGACAC/TGAAAG 1 H/H syn110Minor allele frequency- T:0.18NA EU EA WA 818
    rs23958391,2
    A,C,F,H,O106621673(+) AAGTGA/GGAATG 1 -- int116Minor allele frequency- N:0.00EA NA EU WA 1398
    rs69717741,2
    A,C,F,H106621375(+) TTCCAA/GTCTAG 1 -- int111Minor allele frequency- G:0.13EU EA WA NA 980
    rs109535311,2
    A,C,F,H106615103(+) TAAGTC/TGATGA 1 -- int111Minor allele frequency- T:0.14EU EA WA NA 980
    rs69476751,2
    A,C,F,H106604420(+) AGGCTT/CAAAAT 1 -- int12Minor allele frequency- C:0.14EU WA 232
    rs10029351,2
    A,C,F,H106619597(-) agtcaC/Tagcca 1 -- int110Minor allele frequency- T:0.17NS MN EU EA WA 690
    About this table

    HapMap Linkage Disequilibrium images for HBP1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    2 Novoseek disease relationships for HBP1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 38.76 2 9030690 (1), 10030670 (1)
    tumors 2.51 5 19223422 (2), 15225871 (2), 16179914 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/29 PubMed articles for HBP1 gene (see all 29 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 26959 HGNC: 23200 AceView: HBP1 Ensembl:ENSG00000105856 euGenes: HUgn26959
    ECgene: HBP1 H-InvDB: HBP1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for HBP1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for HBP1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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