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HBG2 Gene

protein-coding GIFtS: 54

GC11M005230

hemoglobin, gamma G
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ76540 ^²
Gamma-2-globin ^³
OTTHUMP00000069638 ^²
methemoglobin ^²

Descriptions
G-gamma globin ^²
Hb F Ggamma ^³
Hemoglobin gamma-2 chain ^³
Hemoglobin gamma-G chain ^³
abnormal hemoglobin ^²
hemoglobin gamma-G ^²
hemoglobin, gamma G ^²

External Ids
HGNC: 4832¹
Entrez Gene: 3048²
UniProtKB: P69892³
Ensembl: ENSG00000196565⁷

Search outside databases for aliases for HBG2 gene

Previous GC identifers: GC11M006018 GC11M005572 GC11M005229 GC11M005216 GC11M005235

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HBG2:

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone

marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is

normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related

conditions, gamma chain production continues into adulthood. The two types of gamma chains differ

at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the

A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the

beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

[provided by RefSeq]

UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892

Function: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains

Gene Wiki entry for HBG2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HBG2 gene

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5

HBG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M005230: (about GC identifiers)

Start:	5,230,996 bp from pter
End:	5,623,595 bp from pter
Size:	392,600 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892 (See protein sequence)

Recommended Name: Hemoglobin subunit gamma-2

Size: 147 amino acids; 16126 Da

Subunit: Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F)

Developmental stage: Expressed until four or five weeks after birth

PDB structures from and Proteopedia :

1FDH (3D)

Secondary accessions: P02096 P62027 Q68NH9 Q96FH7

Post-translational modifications:

Acetylation of Gly-2 converts Hb F to the minor Hb F1¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000175.1

ENSEMBL proteins:

ENSP00000369597 ENSP00000369609 ENSP00000338082 ENSP00000369602

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for HBG2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (fetal hemoglobin)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: HBG2

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005833	hemoglobin complex	IEA	--

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Antibodies for HBG2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (fetal hemoglobin), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for HBG2

Assays for HBG2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P69892

ProtoNet protein and cluster: P69892

2 Blocks protein families:

IPB001032 Leghaemoglobin

IPB002337 Beta haemoglobin signature

UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892

Similarity: Belongs to the globin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NG_000007

Applied Biosystems Silencer® siRNAs for HBG2

Sigma-Aldrich siRNA for HBG2

Sigma-Aldrich shRNA for HBG2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HBG2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000184
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000184
untagged cDNA clones in CMV expression vector (see all 2): NM_000184

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000184

UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892

Function: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains

Genatlas biochemistry entry for HBG2:

globin,gamma G,fetal (G 136)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005344	oxygen transporter activity	IEA	--
GO:0019825	oxygen binding	IEA	--
GO:0020037	heme binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Interacting proteins for HBG2 (P69892²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
HBA1 P69905² MINT-24785
HBA2 P69905² MINT-24785
About this table
2 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015671 oxygen transport IEA --
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HBG2
10/51 Novoseek chemical compound relationships for HBG2 gene (see all 51 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
methylene	77.21	49	10397228 (5), 15753496 (2), 14647658 (2), 9776968 (2) (see all 32)
sodium nitrite	75.48	18	8956097 (2), 2093192 (1), 17065881 (1), 2254586 (1) (see all 16)
n,n-dimethylhydroxylamine	73.09	1	2156749 (1)
oxygen	71.23	132	10956082 (3), 14632342 (2), 15753496 (2), 16517943 (2) (see all 98)
no-dimethylhydroxylamine	69.65	1	11042038 (1)
nitric oxide	66.46	142	12536266 (6), 10809266 (5), 2093192 (4), 9681784 (4) (see all 73)
23-diphosphoglycerate	65.71	3	17174731 (1), 1458154 (1)
cyanide	65.57	40	8956097 (5), 8363114 (3), 2254586 (2), 8353957 (2) (see all 21)
de-oxy	64.44	6	11841242 (2), 12468537 (1), 12668472 (1), 11916017 (1) (see all 5)
2-amino-5-methylphenol	63.47	2	1329970 (1), 11286320 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NG_000007

Sigma-Aldrich siRNA for HBG2

Sigma-Aldrich shRNA for HBG2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000184

REFSEQ mRNAs for HBG2 gene:

NM_000184.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000184

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000184
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000184
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000184

Additional cDNA sequence:

AF110493.1 AK290492.1 BC022184.1 BC029387.1 BC130457.1 BC130459.1 CR593022.1 CR593357.1

CR593470.1 CR593826.1 CR594576.1 CR595029.1 CR595535.1 CR599317.1 CR602719.1 CR602897.1

CR603041.1 CR604223.1 CR607395.1 CR609361.1 CR610392.1 CR613701.1 CR613883.1 CR615907.1

CR616680.1 DQ656066.1 DQ656067.1 M11427.1 M15386.1 X55656.1 X55657.1

24/41 DOTS entries (see all 41 ):

DT.95186195 DT.95221675 DT.98083189 DT.91786228 DT.100890392 DT.95371917 DT.120723250 DT.95180915

DT.75131589 DT.91866943 DT.100774732 DT.100806001 DT.95298167 DT.95230852 DT.100044348 DT.91790886

DT.95092533 DT.95323075 DT.120723406 DT.91674094 DT.87014143 DT.95233683 DT.95124981 DT.91847199

24/50 AceView cDNA sequences (see all 50 ):

CR603041 CR593357 CR594576 CR613883 X55657 CR602897 CR625875 CR610392

CR614139 CR619706 CR626466 CR607395 CR626417 CR615907 CR599317 CR604223

CR609361 CR622267 CR613701 CR593022 AF110493 CR602719 NM_000184 CR593470

highest scoring ESTs for HBG2:

AA300241 AA330866 AF075322 AI064859 AI110824 AI114635 AI114744 AI114796 AI114829 AI114839

Unigene Cluster for HBG2:

Hemoglobin, gamma G

Hs.302145 [show with all ESTs]

Unigene Representative Sequence: CR616680

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000380247 ENST00000380259 ENST00000336906 ENST00000380252

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HBG2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HBG2

¹ / ² / ³

7 probe-sets matching HBG2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38585_at²^{, 3}	U95-A	2	1.00	0.50	1.00	1.00	M91036	0.20	0.50	0.38	1
204419_x_at²^{, 3}	U133-A	5	1.00	0.46	--	--	NM_000184	0.60	0.83	0.73	1
213515_x_at²^{, 3}	U133-A	5	1.00	0.43	--	--	AI133353	0.40	0.75	0.60	1
204848_x_at²^{, 3}	U133-A	5	0.91	0.41	--	--	NM_000559	0.40	0.50	0.45	1
204419_x_at²	U133Plus2	5	1.00	0.46	--	--	--	--	--	--	--
213515_x_at²	U133Plus2	5	1.00	0.43	--	--	--	--	--	--	--
204848_x_at²	U133Plus2	5	0.91	0.41	--	--	--	--	--	--	--

GeneDecks HBG2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.302145
UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892
Tissue specificity: Red blood cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HBG2 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	HBG2¹	--	hemoglobin, gamma G	99.55(n) 100(a)	736917 XM_001136242.1 XP_001136242.1
rat (Rattus norvegicus)	Hbe2¹	--	hemoglobin, epsilon 2	78.68(n) 74.83(a)	502359 NM_001024805.1 NP_001019976.1
rainbow trout (Oncorhynchus mykiss)	BX078477.1²	--	--	74.08(n)	BX078477.1

About this table Species with no ortholog for HBG2

ENSEMBL Gene Tree for HBG2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HBG2 gene

HBB² HBE1² CYGB² HBG1² HBD²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/70 NCBI SNPs in HBG2 are shown (see all 70 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2855122^1,2	A,C,F,H,O	5233812(-)	`CTGACA/GTCATA`	1	--	ng3¹		16		EU EA WA NA	1620
--	rs2011051^1,2	A,C,F,H	5233394(-)	`ATCAGA/CCAGCA`	1	--	ng3¹		5		MN EU EA WA	596
	rs2855123^1,2	A,C,F,H	5233654(-)	`CTGAGT/ATACAG`	1	--	ng3¹		8		EU EA WA	838
	rs2236794^1,2	A,C	5230843(-)	`ATGTGA/GGTTTT`	1	--	ng5¹		0	--	--	--	--
--	rs10768707^1,2	A,C	5230498(+)	`CTCCCC/TGTAGA`	1	--	ng5¹		0	--	--	--	--
	rs2855121^1,2	C	5233867(-)	`TGATAA/GGTTAG`	1	--	ng3¹		0	--	--	--	--
--	rs35720845^1,2	F	5232813(+)	`TGCTTGCTT/- AATTT`	1	--	ng3¹		5		EU EA NA MN	430
	rs10128653^1,2	H	5234037(+)	`TTAAAA/CTAAAA`	1	--	ng3¹		4		EU EA WA	382
--	rs7482144^1,2	C	5232745(+)	`CCAGGA/GACCGT`	1	--	ng3¹		0	--	--	--	--
--	rs1894397^1,2	C	5232563(-)	`CTGAGA/GTTATC`	1	--	ut5¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for HBG2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 142250 disorders: 141749

UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892

Some gamma variants can cause severe jaundice and cyanosis in premature and new born

babies

10/60 Novoseek disease relationships for HBG2 gene (see all 60 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
methemoglobinemia	96.11	44	14647658 (2), 9298047 (2), 7931458 (2), 8363684 (1) (see all 35)
methemoglobinemia acquired	92.48	2	15342970 (1), 10870338 (1)
sulfhemoglobinemia	82.88	1	15886294 (1)
methemoglobinemia hereditary	80.88	1	8657061 (1)
hemolysis	69.76	28	19135990 (2), 18702879 (2), 7679879 (1), 8090078 (1) (see all 20)
g6pd deficiency	63.68	4	9523930 (2), 1523481 (1)
sickle cell disease	52.17	3	2393709 (1), 9545536 (1), 18667698 (1)
hypertension pulmonary	51.15	4	12161242 (1), 11969358 (1), 8771498 (1), 9233741 (1)
poisoning	51.10	17	8353957 (1), 15208879 (1), 17145698 (1), 2067134 (1) (see all 14)
anemia hemolytic	47.67	3	12006477 (1), 16132702 (1), 14654534 (1)

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Human Gene Mutation Database: HBG2
Genetic Association Database: HBG2
Human Genome Epidemiology Navigator: HBG2 (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/635 PubMed articles for HBG2 gene (see all 635 ):

A new G(gamma) chain variant: Hb F-Bron [gamma20(B2)Val-->Ala]. (PubMed id 16370494)^{3, 4} Lacan P.... Francina A. (2005)
Severe hereditary haemolytic anaemia in a Caucasian newborn: a new fetal haemoglobin variant Hb F-Bonheiden ((G)gamma 38(C4) Thr-->Pro). (PubMed id 15645283)^{3, 4} Van den Driessche M.... Philippe M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A new Ggamma chain variant: Hb F-Coignieres [gamma75(E19)Ile-->Val]. (PubMed id 11791877)^{3, 4} Wajcman H.... Bardakdjian-Michau J. (2001)
Genetic factors affecting clinical severity in beta-thalassemia syndromes. (PubMed id 11132233)^{3, 6} Winichagoon P....Wasi P. (2000)
A new, electrophoretically silent, fetal hemoglobin variant: Hb F- Calabria Ggamma118(GH1)Phe-->Leu. (PubMed id 10722114)^{3, 4} Manca L.... Masala B. (2000)
Two new Ggamma chain variants: Hb F-clamart [gamma17(A14)Lys-->Asn] and Hb F-Ouled Rabah [gamma19(B1)Asn-->Lys]. (PubMed id 10722115)^{3, 4} Wajcman H.... Ducrocq R. (2000)
HbF-Lesvos: an HbF variant due to a novel G gamma mutation (G gamma 75 ATA-->ACA) detected in a Greek family. (PubMed id 8566966)^{3, 4} Papadakis M.N.... Loutradi-Anagnostou A. (1996)
Two fetal hemoglobin variants affecting the same residue: Hb F- Emirates [G gamma 59(E3)Lys-->Glu] and Hb F-Sacromonte [G gamma 59(E3)Lys-->Gln]. (PubMed id 7558873)^{3, 4} Abbes S.... Wajcman H. (1995)
Hb F-Veleta or alpha 2 G gamma(2)40(C6)Arg-->Gly. (PubMed id 8718700)^{3, 4} de Pablos Gallego J.M.... Huisman T.H.J. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3048	HGNC: 4832	AceView: HBG2andHBG1	Ensembl:ENSG00000196565	euGenes: HUgn3048
ECgene: HBG2	H-InvDB: HBG2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
HbVar	http://globin.bx.psu.edu/cgi-bin/hbvar/query_vars3?mode=directlink&gene=HBG2

Licensable Technologies for HBG2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for HBG2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HBG2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HBG2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Proteins for HBG2
	Lentivirus-delivered shRNAs for HBG2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for HBG2

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Antibodies for HBG2

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HBG2 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for HBG2

Summaries
for HBG2

Genomic Location
for HBG2

Proteins
for HBG2

Protein Domains/
Families
for HBG2

Gene Function
for HBG2

Pathways & Interactions
for HBG2

Drugs & Compounds
for HBG2

Transcripts
for HBG2

Expression
for HBG2

Orthologs
for HBG2

Paralogs
for HBG2

SNPs/Variants
for HBG2

Disorders & Mutations
for HBG2

Medical News
for HBG2

Publications
for HBG2

Search for HBG2

Genome Databases showing HBG2

Other Databases showing HBG2

Specialized Databases showing HBG2

Licensable Technologies
for HBG2

Services
for HBG2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HBG2 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor HBG2

Summariesfor HBG2

Genomic Locationfor HBG2

Proteinsfor HBG2

Protein Domains/Familiesfor HBG2

Gene Functionfor HBG2

Pathways & Interactionsfor HBG2

Drugs & Compoundsfor HBG2

Transcriptsfor HBG2

Expression for HBG2

Orthologsfor HBG2

Paralogsfor HBG2

SNPs/Variantsfor HBG2

Disorders & Mutationsfor HBG2

Medical Newsfor HBG2

Publicationsfor HBG2

Search for HBG2

Genome Databases showing HBG2

Other Databases showing HBG2

Specialized Databases showing HBG2

Licensable Technologiesfor HBG2

Servicesfor HBG2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HBG2

Summaries
for HBG2

Genomic Location
for HBG2

Proteins
for HBG2

Protein Domains/
Families
for HBG2

Gene Function
for HBG2

Pathways & Interactions
for HBG2

Drugs & Compounds
for HBG2

Transcripts
for HBG2

Expression
for HBG2

Orthologs
for HBG2

Paralogs
for HBG2

SNPs/Variants
for HBG2

Disorders & Mutations
for HBG2

Medical News
for HBG2

Publications
for HBG2

Licensable Technologies
for HBG2

Services
for HBG2