HBG2 Gene
protein-coding GIFtS: 56
GCID: GC11M005274
|
|
hemoglobin, gamma G
| |
Aliases
for HBG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hemoglobin, Gamma G1 2 | | G-Gamma Globin Paulinia2 | | Hb F Ggamma2 3 | | Gamma-2-Globin1 | | Hemoglobin Gamma-2 Chain2 3 | | Hemoglobin Subunit Gamma-22 | | Hemoglobin Gamma-G Chain2 3 | | Methemoglobin1 | | TNCY2 | | Gamma-2-Globin1 | | Abnormal Hemoglobin2 | | |
Export aliases for HBG2 gene to outside databasesPrevious GC identifers: GC11M006018 GC11M005572 GC11M005229 GC11M005216 GC11M005235 GC11M005230 GC11M004934 |
Summaries
for HBG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HBG2:
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gammachains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin(HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. Thetwo types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine isfound in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globincluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892Function: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains
Gene Wiki entry for HBG2
|
Genomic Views
for HBG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HBG2 gene promoter:
TBP TFIID c-Myb HNF-4alpha1 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HBG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HBG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5HBG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M005274: view genomic region
(about GC identifiers)
Start:
|
5,274,420 bp from pter |
End:
|
5,667,019 bp from pter |
Size:
|
392,600 bases |
Orientation:
|
minus strand |
|
Proteins
for HBG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892 (See
protein sequence)Recommended Name: Hemoglobin subunit gamma-2 Size: 147 amino acids; 16126 Da
Subunit: Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F)
Developmental stage: Expressed until four or five weeks after birth
Sequence caution: Sequence=AAB50159.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from  and Proteopedia  for HBG2:1FDH (3D)
Secondary accessions: A8MZE0 P02096 P62027 Q14491 Q68NH9 Q96FH6 Q96FH7Explore the universe of human proteins at neXtProt for HBG2: NX_P69892
Post-translational modifications:
Acetylation of Gly-2 converts Hb F to the minor Hb F11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P69892
HBG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000175.1
ENSEMBL proteins: ENSP00000369602 ENSP00000369609 ENSP00000390765 ENSP00000338082 Reactome Protein details: P69892
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HBG2 for ontologies About GeneDecksing
HBG2 Antibody Products:
Assay Products for HBG2: |
Protein
Domains /
Families
for HBG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HBG2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P69892ProtoNet protein and cluster: P69892 2 Blocks protein families: IPB001032 Leghaemoglobin IPB002337 Beta haemoglobin signature
UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892Similarity: Belongs to the globin family |
Function
for HBG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892Function: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains Genatlas biochemistry entry for HBG2:globin,gamma G,fetal (G 136)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HBG2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HBG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HBG2 (NM_000184) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HBG2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HBG2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
HBG2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HBG2:
|
Pathways & Interactions
for HBG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Expression of globin genes under control of the beta globin control region | | | 2 | Factors involved in megakaryocyte development and platelet production | | | 3 | p70S6K Signaling | | | 4 | Platelet activation, signaling and aggregation | | | 5 | ErbB4 Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HBG2
3 
Reactome Pathways for HBG2
HBG2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HBG2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/14 Interacting proteins for HBG2 (P698922, 3 ENSP000003380824) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007596 | blood coagulation |
TAS | -- |
HBG2 for ontologies About GeneDecksing
|
Drugs & Compounds
for HBG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HBG2 for compounds About GeneDecksing
 Browse Tocris compounds for HBG2
2 HMDB Compounds for HBG2 About this table
10/104 Novoseek chemical compound relationships for HBG2 gene (see all 104) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| benzocaine |
86.9 |
18 |
8644973 (2), 16382850 (2), 8092589 (2), 1601230 (1) (see all 13) |
| methylene |
77.3 |
49 |
10397228 (5), 15753496 (2), 14647658 (2), 9776968 (2) (see all 32) |
| sodium nitrite |
75.3 |
19 |
8956097 (2), 2093192 (1), 17065881 (1), 2254586 (1) (see all 17) |
| oxygen |
71.5 |
141 |
10956082 (3), 14632342 (2), 15753496 (2), 16517943 (2) (see all 99) |
| n,n-dimethylhydroxylamine |
71.5 |
1 |
2156749 (1) |
| sulofenur |
70.3 |
5 |
1433369 (2), 1676639 (1), 14654534 (1) |
| no-dimethylhydroxylamine |
69.3 |
1 |
11042038 (1) |
| phenazopyridine |
67.4 |
1 |
12901999 (1) |
| nitric oxide |
66.7 |
149 |
12536266 (6), 10809266 (5), 2093192 (4), 9681784 (4) (see all 76) |
| dapsone |
66.7 |
12 |
19998329 (3), 14647658 (2), 7931458 (2), 16794511 (1) (see all 8) |
Search CenterWatch for drugs/clinical trials and news about HBG2
|
Transcripts
for HBG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HBG2 gene: NM_000184.2 Unigene Cluster for HBG2: Hemoglobin, gamma G Hs.302145 [show with all ESTs]Unigene Representative Sequence: DQ6560665 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380252 ENST00000380259(uc001mai.1 uc001maj.1 uc001mak.1)
ENST00000459655 ENST00000444587 ENST00000336906
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HBG2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HBG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HBG2 (NM_000184) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HBG2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HBG2 |
Additional cDNA sequence: AF110493.1 AK290492.1 BC029387.1 BC130457.1 BC130459.1 DQ656066.1 DQ656067.1 M11427.1 M15386.1 X55656.1 X55657.1 24/40 DOTS entries (see all 40): DT.95186195 DT.95221675 DT.98083189 DT.91786228 DT.100890392 DT.95371917 DT.75131589 DT.95298167 DT.100806001 DT.95230852 DT.100044348 DT.91866943 DT.120723250 DT.95180915 DT.100774732 DT.91790886 DT.95092533 DT.87014143 DT.95323075 DT.95124981 DT.101983809 DT.120723406 DT.95102656 DT.99999120 24/50 AceView cDNA sequences (see all 50): CR595029 CR603041 CR619706 CR595535 CR609361 CR613883 CR594576 CR615907 CR626417 CR604223 NM_000184 NM_000559 CR626466 CR593826 CR610392 CR602719 CR607395 CR602897 CR613701 CR599317 CR614139 CR593022 AF110493 CR593357
GeneLoc Exon Structure
|
Expression
for HBG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HBG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HBG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HBG2
SOURCE GeneReport for Unigene cluster: Hs.302145
UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892Tissue specificity: Red blood cells
SABiosciences Custom PCR Arrays for HBG2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HBG2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HBG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HBG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HBG2 |
Orthologs
for HBG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HBG2 gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for HBG2 (if available)
TreeFam Gene Tree for HBG2 (if available) |
Paralogs
for HBG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HBG2 gene
- HBE12 CYGB2 HBZ2 HBD2 HBG12 HBA22 HBB2 HBQ12
- HBA12 HBM2
13 SIMAP similar genes for HBG2 using alignment to 9 protein entries: HBG2_HUMAN (see all proteins):HBG1 G-gamma HBD/HBB HBE1 HBD HBB
HBA2 HBA1 HBZ HBM HBQ1 CYGB
MB
HBG2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HBG2
PGOHUM00000242142
|
Genomic Variants
for HBG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HBG2 (5274420 - 5524420 bp, first 250kb of HBG2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HBG2
3 CNVs: 75527 101115 61094
Human Gene Mutation Database (HGMD): HBG2
Locus Specific Mutation Databases (LSDB): HBG2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HBG2 |
|
Disorders
/ Diseases
for HBG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HBG2 for disorders About GeneDecksing
OMIM gene information: 142250
OMIM disorders: 141749
UniProtKB/Swiss-Prot: HBG2_HUMAN, P69892
Defects in HBG2 are the cause of cyanosis transient neonatal (TNCY) [MIM:613977]. TNCY is a disordercharacterized by cyanosis in the fetus and neonate, due to a defect in the fetal hemoglobin chain which has reducedaffinity for oxygen. Some patients develop anemia resulting from increased destruction of red cells containingabnormal or unstable hemoglobin. The cyanosis resolves spontaneously by 5 to 6 months of age or earlier, as the adultbeta-globin chain is produced and replaces the fetal gamma-globin chain
20/83  diseases for HBG2 (see all 83): About MalaCardsbeta thalassemia fetal hemoglobin quantitative trait locus 1 thalassemia hereditary persistence of fetal hemoglobin
hemoglobin s beta-thalassemia methemoglobinemia iron deficiency anemia sulfhemoglobinemia
status asthmaticus congenital diaphragmatic hernia dyserythropoietic anemia pre-eclampsia
traumatic brain injury congenital dyserythropoietic anemia hemolytic anemia congenital hemolytic anemia
sickle cell disease cavernous hemangioma subependymoma brain injury
3 diseases from the University of Copenhagen DISEASES database for HBG2:Thalassemia Sickle cell anemia Anemia 10/61 Novoseek disease relationships for HBG2 gene (see all 61) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| methemoglobinemia |
96.3 |
48 |
14647658 (2), 9298047 (2), 7931458 (2), 8363684 (1) (see all 38) |
| methemoglobinemia acquired |
92.4 |
2 |
15342970 (1), 10870338 (1) |
| sulfhemoglobinemia |
81.9 |
1 |
15886294 (1) |
| methemoglobinemia hereditary |
80.6 |
1 |
8657061 (1) |
| hemolysis |
70.7 |
28 |
19135990 (2), 18702879 (2), 7679879 (1), 8090078 (1) (see all 20) |
| g6pd deficiency |
67.6 |
5 |
9523930 (2), 19726375 (1), 1523481 (1) |
| hypertension pulmonary |
52.7 |
4 |
12161242 (1), 11969358 (1), 8771498 (1), 9233741 (1) |
| poisoning |
51.1 |
17 |
8353957 (1), 15208879 (1), 17145698 (1), 2067134 (1) (see all 14) |
| sickle cell disease |
50.7 |
3 |
2393709 (1), 9545536 (1), 18667698 (1) |
| anemia hemolytic |
48.1 |
3 |
12006477 (1), 16132702 (1), 14654534 (1) |
Genetic Association Database (GAD): HBG2
Human Genome Epidemiology (HuGE) Navigator: HBG2 (7 documents)
Export disorders for HBG2 gene to outside databases
|
Publications
for HBG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HBG2 gene, integrated from 9 sources (see all 749):
(articles sorted by number of sources associating them with HBG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A hemoglobin variant associated with neonatal cyanosi s and anemia. (PubMed id 21561349)1, 2 Crowley M.A....Weiss M.J. (2011)
- A new G(gamma) chain variant: Hb F-Bron [gamma20(B2)Val-->Ala]. (PubMed id 16370494)1, 2 Lacan P.... Francina A. (2005)
- Severe hereditary haemolytic anaemia in a Caucasian newborn: a new fetal haemoglobin variant Hb F-Bonheiden ((G)gamma 38(C4) Thr-->Pro). (PubMed id 15645283)1, 2 Van den Driessche M.... Philippe M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A new Ggamma chain variant: Hb F-Coignieres [gamma75(E19)Ile-->Val]. (PubMed id 11791877)1, 2 Wajcman H.... Bardakdjian-Michau J. (2001)
- Genetic factors affecting clinical severity in beta-thalassemia syndromes. (PubMed id 11132233)1, 4 Winichagoon P....Wasi P. (2000)
- A new, electrophoretically silent, fetal hemoglobin variant: Hb F- Calabria Ggamma118(GH1)Phe-->Leu. (PubMed id 10722114)1, 2 Manca L.... Masala B. (2000)
- Two new Ggamma chain variants: Hb F-clamart [gamma17(A14)Lys-->Asn] and Hb F-Ouled Rabah [gamma19(B1)Asn-->Lys]. (PubMed id 10722115)1, 2 Wajcman H.... Ducrocq R. (2000)
- HbF-Lesvos: an HbF variant due to a novel G gamma mutation (G gamma 75 ATA-->ACA) detected in a Greek family. (PubMed id 8566966)1, 2 Papadakis M.N.... Loutradi-Anagnostou A. (1996)
- Two fetal hemoglobin variants affecting the same residue: Hb F- Emirates [G gamma 59(E3)Lys-->Glu] and Hb F-Sacromonte [G gamma 59(E3)Lys-->Gln]. (PubMed id 7558873)1, 2 Abbes S.... Wajcman H. (1995)
|
External Searches for HBG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HBG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HBG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HBG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HBG2 | Pharmacogenomics, SNPs, Pathways | | HbVar | http://globin.bx.psu.edu/cgi-bin/hbvar/query_vars3?mode=directlink&gene=HBG2 |
|
| | |
About This Section
| Patent Information for HBG2 gene:
Search GeneIP for patents involving HBG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HBG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HBG2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HBG2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HBG2 | | | OriGene Protein Over-expression Lysate for HBG2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HBG2 | | OriGene 3'-UTR Clone for HBG2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HBG2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HBG2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HBG2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HBG2 | | OriGene Custom Protein Services for HBG2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HBG2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HBG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HBG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HBG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HBG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HBG2 |
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| | | | Search Tocris compounds for HBG2 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for HBG2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HBG2 |
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