Aliases for HBG2 Gene
Aliases for HBG2 Gene
External Ids for HBG2 Gene
- HGNC: 4832
- Entrez Gene: 3048
- Ensembl: ENSG00000196565
- OMIM: 142250
- UniProtKB: P69892
Previous GeneCards Identifiers for HBG2 Gene
- GC11M006018
- GC11M005572
- GC11M005229
- GC11M005216
- GC11M005235
- GC11M005230
- GC11M005274
- GC11M004934
Summaries for HBG2 Gene
-
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
GeneCards Summary for HBG2 Gene
HBG2 (Hemoglobin Subunit Gamma 2) is a Protein Coding gene. Diseases associated with HBG2 include Cyanosis, Transient Neonatal and Hemoglobinopathy Toms River. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is HBG1.
UniProtKB/Swiss-Prot for HBG2 Gene
-
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
Additional gene information for HBG2 Gene
- Monarch Initiative
- Search for HBG2 at DataMed
- Search for HBG2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HBG2 Gene
Genomics for HBG2 Gene
GeneHancer (GH) Regulatory Elements for HBG2 Gene
- Top Transcription factor binding sites by QIAGEN in the HBG2 gene promoter:
Regulatory Element Products
Genomic Locations for HBG2 Gene
- chr11:5,253,190-5,645,789
- (GRCh38/hg38)
- Size:
- 392,600 bases
- Orientation:
- Minus strand
- chr11:5,274,420-5,667,019
- (GRCh37/hg19)
Genomic View for HBG2 Gene
- Cytogenetic band:
-
- 11p15.4 by Ensembl
- 11p15.4 by Entrez Gene
- 11p15.4 by HGNC


RefSeq DNA sequence for HBG2 Gene
Proteins for HBG2 Gene
-
Protein details for HBG2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P69892-HBG2_HUMAN
- Recommended name:
- Hemoglobin subunit gamma-2
- Protein Accession:
- P69892
- A8MZE0
- P02096
- P62027
- Q14491
- Q68NH9
- Q96FH6
- Q96FH7
Protein attributes for HBG2 Gene
- Size:
- 147 amino acids
- Molecular mass:
- 16126 Da
- Quaternary structure:
-
- Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).
- SequenceCaution:
-
- Sequence=AAB50159.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for HBG2 Gene
Post-translational modifications for HBG2 Gene
- Acetylation of Gly-2 converts Hb F to the minor Hb F1.
Other Protein References for HBG2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HBG2
-
Abcam antibodies for HBG2
-
Cloud-Clone Corp. Antibodies for HBG2
- Invitrogen Antibodies for HBG2
- GeneTex HBG2 antibody for HBG2
-
Santa Cruz Biotechnology (SCBT) Antibodies for HBG2
Protein Products
-
OriGene Purified Proteins for HBG2
- Search Origene for MassSpec and Protein Over-expression Lysates for HBG2
- Origene Custom Protein Services for HBG2
- ProSpec Recombinant Proteins for HBG2
-
Cloud-Clone Corp. Proteins for HBG2
- GeneTex Proteins for HBG2
-
Abcam proteins for HBG2
Assay Products
-
Cloud-Clone Corp. Assay Kits for HBG2
No data available for DME Specific Peptides for HBG2 Gene
Domains & Families for HBG2 Gene
Gene Families for HBG2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for HBG2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HBG2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P69892- Family:
-
- Belongs to the globin family.
Function for HBG2 Gene
Molecular function for HBG2 Gene
- GENATLAS Biochemistry:
- globin,gamma G,fetal (G 136)
- UniProtKB/Swiss-Prot Function:
- Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
Phenotypes From GWAS Catalog for HBG2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005344 | oxygen carrier activity | IEA | -- |
GO:0005506 | iron ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | -- |
GO:0019825 | oxygen binding | IEA | -- |
GO:0020037 | heme binding | IEA | -- |
Phenotypes for HBG2 Gene
- MGI mutant phenotypes for HBG2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for HBG2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HBG2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HBG2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HBG2 gene
- Search ViGene Biosciences for HBG2
CRISPR Products
- Browse CRISPR knockouts for HBG2
- genomics-online: gRNA clones - Search results for 39 available MHB gene related products
- Overview of 39 available MHB gene related products
-
Recommended
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- Applied Biological Materials CRISPR for HBG2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HBG2
- GenScript: Design CRISPR guide RNA sequences for HBG2
miRNA Products
- Search ViGene Biosciences for HBG2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HBG2
- Browse OriGene Inhibitory RNA Products For HBG2
- genomics-online: shRNA clones - Search results for 39 available MHB gene related products
- Overview of 39 available MHB gene related products
-
Recommended
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
-
ViGene Biosciences ready-to-package AAV shRNAs for HBG2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HBG2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HBG2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 39 available MHB gene related products
- Overview of 39 available MHB gene related products
-
Recommended
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- orf clones - Search results for 39 available MHB gene related products
- Overview of 39 available MHB gene related products
-
Recommended
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- Applied Biological Materials Clones for HBG2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HBG2
-
ViGene Biosciences adenoviral particle packaged cDNA for HBG2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HBG2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HBG2 gene
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for HBG2 Gene
Localization for HBG2 Gene
- Vesicles (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0005833 | hemoglobin complex | IEA | -- |
GO:0072562 | blood microparticle | HDA,IDA | 22516433 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for HBG2 Gene
Pathways & Interactions for HBG2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-2 Pathway |
.34
|
|
2 | p70S6K Signaling |
.60
|
|
3 | Factors involved in megakaryocyte development and platelet production | ||
4 | Response to elevated platelet cytosolic Ca2+ |
.44
|
Pathways by source for HBG2 Gene
2 Reactome pathways for HBG2 Gene
2 Qiagen pathways for HBG2 Gene
Interacting Proteins for HBG2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006810 | transport | IEA | -- |
GO:0007596 | blood coagulation | TAS | -- |
GO:0015671 | oxygen transport | IEA | -- |
No data available for SIGNOR curated interactions for HBG2 Gene
Transcripts for HBG2 Gene
mRNA/cDNA for HBG2 Gene
- (1) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (50) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for HBG2
- genomics-online: gRNA clones - Search results for 39 available MHB gene related products
- Overview of 39 available MHB gene related products
-
Recommended
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- Applied Biological Materials CRISPR for HBG2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HBG2
- GenScript: Design CRISPR guide RNA sequences for HBG2
miRNA Products
- Search ViGene Biosciences for HBG2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HBG2
- Browse OriGene Inhibitory RNA Products For HBG2
- genomics-online: shRNA clones - Search results for 39 available MHB gene related products
- Overview of 39 available MHB gene related products
-
Recommended
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
-
ViGene Biosciences ready-to-package AAV shRNAs for HBG2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HBG2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HBG2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 39 available MHB gene related products
- Overview of 39 available MHB gene related products
-
Recommended
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- orf clones - Search results for 39 available MHB gene related products
- Overview of 39 available MHB gene related products
-
Recommended
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- Applied Biological Materials Clones for HBG2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HBG2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Primitive Erythrocytes Extraembryonic Blood Islands
- Definitive Erythrocytes Liver Bud
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Cardiac Fibroblasts Myocardium
- Cardiac Crescent Cells Cardiac Crescent
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Primitive Erythrocytes Extraembryonic Blood Islands
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Limb (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
- Mesenchymal Condensate Cells Zeugopod
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
- Mesenchymal Condensate Cells Zeugopod
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Choroid Plexus Progenitor Cells Choroid Plexus
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Kidney (Urinary System)
-
Ovary (Reproductive System)
- Ovarian Somatic Cells Ovigerous Cord
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
-
Tooth
- Dental Mesenchymal Cells Branchial Arch 1
-
Liver (Hepatobiliary System)
- Definitive Erythrocytes Liver Bud
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
- Intermediate Mesoderm (Gastrulation Derivatives)
-
Spleen (Hematopoietic System)
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for HBG2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HBG2 Gene
NURSA nuclear receptor signaling pathways regulating expression of HBG2 Gene:
HBG2SOURCE GeneReport for Unigene cluster for HBG2 Gene:
Hs.302145mRNA Expression by UniProt/SwissProt for HBG2 Gene:
P69892-HBG2_HUMANEvidence on tissue expression from TISSUES for HBG2 Gene
- Spleen(4.9)
- Liver(4.8)
- Lung(4.8)
- Nervous system(4.8)
- Bone marrow(4.4)
- Pancreas(4.4)
- Blood(4.2)
- Heart(3.8)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HBG2 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- skeleton
- thymus
- liver
- spleen
- blood
- blood vessel
- bone marrow
- coagulation system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for HBG2
-
OriGene qPCR primer pairs and template standards for HBG2
- genomics-online: primer clones - Search results for 39 available MHB gene related products
- Overview of 39 available MHB gene related products
-
Recommended
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pZIP-mCMV-ZsGreen
- pDONR223
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pCas-Guide
- pPM-C-His
- pPM-C-HA
- pCMV6-AC-GFP
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-MBP
- pPB-N-His
- pPB-His-GST
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
Orthologs for HBG2 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | HBG2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | HBE1 33 |
|
||
-- 34 |
|
OneToMany | |||
cow (Bos Taurus) |
Mammalia | HBE1 33 |
|
||
HBE4 34 |
|
ManyToMany | |||
HBE2 34 |
|
ManyToMany | |||
mouse (Mus musculus) |
Mammalia | Hbb-y 33 16 |
|
||
Hbb-bh1 34 |
|
OneToMany | |||
rat (Rattus norvegicus) |
Mammalia | Hbe1 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
chicken (Gallus gallus) |
Aves | HBB 34 |
|
ManyToMany | |
HBE1 34 |
|
ManyToMany | |||
HBG1 34 |
|
ManyToMany | |||
HBE 34 |
|
ManyToMany | |||
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100037901 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | hbaa1 34 34 |
|
ManyToMany | |
hbae3 34 |
|
ManyToMany | |||
hbz 34 |
|
ManyToMany | |||
si:ch211-5k11.6 34 |
|
ManyToMany | |||
hbae1 34 34 |
|
ManyToMany | |||
si:ch211-5k11.2 34 |
|
ManyToMany |
- Species where no ortholog for HBG2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HBG2 Gene
(13) SIMAP similar genes for HBG2 Gene using alignment to 9 proteins:
Pseudogenes.org Pseudogenes for HBG2 Gene
Variants for HBG2 Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs104894225 | other, HEMOGLOBIN F (WAYNESBORO), HEMOGLOBIN F (LESVOS) | 5,254,380(-) | A/G | coding_sequence_variant, missense_variant | |
rs281860594 | other, HEMOGLOBIN F (MINOO) | 5,254,390(-) | C/G | coding_sequence_variant, missense_variant | |
rs281864890 | other, HEMOGLOBIN F (HEATHER) | 5,254,691(-) | G/C/T | coding_sequence_variant, missense_variant | |
rs281864891 | other, HEMOGLOBIN F (GRANADA), HEMOGLOBIN F (URUMQI) | 5,254,661(-) | T/A/C | coding_sequence_variant, missense_variant | |
rs281864892 | other, HEMOGLOBIN F (AUSTELL) | 5,254,485(-) | C/T | coding_sequence_variant, missense_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1597n54 | CNV | loss | 21841781 |
dgv194n67 | CNV | gain | 20364138 |
esv2648523 | CNV | deletion | 19546169 |
esv2671356 | CNV | deletion | 23128226 |
esv2744059 | CNV | deletion | 23290073 |
esv3547249 | CNV | deletion | 23714750 |
esv3625218 | CNV | loss | 21293372 |
esv3625219 | CNV | loss | 21293372 |
esv3625220 | CNV | gain | 21293372 |
esv5471 | CNV | loss | 19470904 |
nsv1036997 | CNV | gain | 25217958 |
nsv553229 | CNV | gain | 21841781 |
nsv982977 | CNV | duplication | 23825009 |
nsv983203 | CNV | duplication | 23825009 |
Additional Variant Information for HBG2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HBG2 Gene
Disorders for HBG2 Gene

(23) MalaCards diseases for HBG2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
cyanosis, transient neonatal |
|
|
hemoglobinopathy toms river |
|
|
fetal hemoglobin quantitative trait locus 1 |
|
|
hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome |
|
|
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome |
|
|
UniProtKB/Swiss-Prot
HBG2_HUMAN- Cyanosis transient neonatal (TNCY) [MIM:613977]: A disorder characterized by cyanosis in the fetus and neonate, due to a defect in the fetal hemoglobin chain which has reduced affinity for oxygen. Some patients develop anemia resulting from increased destruction of red cells containing abnormal or unstable hemoglobin. The cyanosis resolves spontaneously by 5 to 6 months of age or earlier, as the adult beta-globin chain is produced and replaces the fetal gamma-globin chain. {ECO:0000269 PubMed:19065339, ECO:0000269 PubMed:21561349, ECO:0000269 PubMed:24502349, ECO:0000269 PubMed:2470017, ECO:0000269 PubMed:2483933, ECO:0000269 PubMed:7741137}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for HBG2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for HBG2 Gene
Publications for HBG2 Gene
- A new (G)γ-globin variant causing low oxygen affinity: Hb F-Brugine/Feldkirch [(G)γ105(G7)Leu→His; HBG2: c.317T>A]. (PMID: 24502349) Saller E … Frischknecht H (Hemoglobin 2014) 3 4 58
- A hemoglobin variant associated with neonatal cyanosis and anemia. (PMID: 21561349) Crowley MA … Weiss MJ (The New England journal of medicine 2011) 3 4 58
- The XmnI (G)gamma polymorphism influences hemoglobin F synthesis contrary to BCL11A and HBS1L-MYB SNPs in a cohort of 57 beta-thalassemia intermedia patients. (PMID: 20472475) Nguyen TK … Francina A (Blood cells, molecules & diseases 2010) 3 44 58
- The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter. (PMID: 19050890) Chassanidis C … Kollia P (Annals of hematology 2009) 3 22 58
- Molecular, hematological and clinical aspects of thalassemia major and thalassemia intermedia associated with Hb E-beta-thalassemia in Northeast Thailand. (PMID: 18951049) Nuntakarn L … Wiangnon S (Blood cells, molecules & diseases 2009) 3 44 58
Products for HBG2 Gene
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- Invitrogen Antibodies for HBG2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for HBG2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 22 available HBG2 Antibodies ranked by validation data
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- genomics-online: cdna clones - Search results for 39 available HBG2 gene related products
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- pPM-C-His
- pCas-Guide
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- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pCMV6-AC-GFP
- pPM-C-HA
- pPM-C-His
- pCas-Guide
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pDONR223
- pZIP-mCMV-ZsGreen
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-Entry
- pLenti-U6-sgRNA-PGK-Neo
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pCMV6-AC-GFP
- pPM-C-HA
- pPM-C-His
- pCas-Guide
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pDONR223
- pZIP-mCMV-ZsGreen
Sources for HBG2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (14) ProtoNet
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- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (122) MedlinePlus
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- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (133) ENCODE
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- (144) ProteoGenix
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- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew