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HBG1 Gene

protein-coding   GIFtS: 54
GCID: GC11M005304

Hemoglobin, Gamma A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hemoglobin, Gamma A1 2     A-Gamma Globin2
Hb F Agamma2 3     Gamma A Hemoglobin2
Hemoglobin Gamma-1 Chain2 3     Gamma Globin2
Hemoglobin Gamma-A Chain2 3     gamma-1-globin2
HBGA2     Hemoglobin Subunit Gamma-12
HBGR2     Hemoglobin, Gamma, Regulator Of2
HSGGL12     Gamma-1-globin3

External Ids:    HGNC: 48311   Entrez Gene: 30472   Ensembl: ENSG000002139347   OMIM: 1422005   UniProtKB: P698913   

Export aliases for HBG1 gene to outside databases

Previous GC identifers: GC11M006017 GC11M005571 GC11M005228 GC11M005215 GC11M005234 GC11M005226 GC11M005271 GC11M004928


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HBG1 Gene:
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two
gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult
hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues
into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product
(HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the
genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. (provided by RefSeq,
Jul 2008)

GeneCards Summary for HBG1 Gene:
HBG1 (hemoglobin, gamma A) is a protein-coding gene. Diseases associated with HBG1 include fetal hemoglobin quantitative trait locus 1, and beta thalassemia. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is HBE1.

UniProtKB/Swiss-Prot: HBG1_HUMAN, P69891
Function: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains

Gene Wiki entry for HBG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HBG1 gene promoter:
         TBP   TFIID   c-Myb   STAT3   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HBG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HBG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5

HBG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HBG1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M005304:  view genomic region     (about GC identifiers)

Start:
5,269,313 bp from pter      End:
5,271,122 bp from pter
Size:
1,810 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HBG1_HUMAN, P69891 (See protein sequence)
Recommended Name: Hemoglobin subunit gamma-1  
Size: 147 amino acids; 16140 Da
Subunit: Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F). In the case of
deletions affecting one or more of the alpha chains the excess gamma chains form homotetramers that exhibit
neither Bohr effect nor heme-heme cooperativity (hemoglobin Bart's)
Developmental stage: Expressed until four or five weeks after birth
2 PDB 3D structures from and Proteopedia for HBG1:
1I3D (3D)        1I3E (3D)    
Secondary accessions: P02096 P62027 Q549G1 Q8TDA1 Q96FH7

Explore the universe of human proteins at neXtProt for HBG1: NX_P69891

Explore proteomics data for HBG1 at MOPED

Post-translational modifications: 

  • Acetylation of Gly-2 converts Hb F to the minor Hb F11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HBG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000550.2  
    ENSEMBL proteins: 
     ENSP00000327431  
    Reactome Protein details: P69891

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    Novus Biologicals HBG1 Proteins
    Novus Biologicals HBG1 Lysate
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    ProSpec Recombinant Protein for HBG1
    Browse Proteins at Cloud-Clone Corp.

    HBG1 Antibody Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR012292 Globin_dom
     IPR009050 Globin-like
     IPR000971 Globin
     IPR002337 Haemoglobin_b

    Graphical View of Domain Structure for InterPro Entry P69891

    ProtoNet protein and cluster: P69891

    2 Blocks protein domains:
    IPB001032 Leghaemoglobin
    IPB002337 Beta haemoglobin signature


    UniProtKB/Swiss-Prot: HBG1_HUMAN, P69891
    Similarity: Belongs to the globin family


    HBG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HBG1_HUMAN, P69891
    Function: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains

         Genatlas biochemistry entry for HBG1:
    globin,gamma A,fetal (A 136)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005344oxygen transporter activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0019825oxygen binding IEA--
    GO:0020037heme binding IEA--
         
    HBG1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Hbb-bh1):
     normal 

    HBG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hbb-bh1Hbb-tm1Fier for HBG1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HBG1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HBG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HBG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HBG1

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    Predesigned siRNA for gene silencing in human, mouse, rat HBG1

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HBG1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HBG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005833hemoglobin complex IEA--

    HBG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HBG1 About    
    See pathways by source

    SuperPathContained pathways About
    1p70S6K Signaling
    p70S6K Signaling0.60
    2ErbB4 Pathway
    IL-4 Pathway0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HBG1
        p70S6K Signaling
    IL-4 Pathway

    1 Reactome Pathway for HBG1
        Factors involved in megakaryocyte development and platelet production



    HBG1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HBG1
    Interactions:

        GeneGlobe Interaction Network for HBG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for HBG1 (P698913 ENSP000003274314) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL2P605203, ENSP000000372434I2D: score=2 STRING: ENSP00000037243
    HBMENSP000003492704STRING: ENSP00000349270
    AHSPENSP000003071994STRING: ENSP00000307199
    CYB5R3ENSP000003384614STRING: ENSP00000338461
    HBA1ENSP000003224214STRING: ENSP00000322421
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--

    HBG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HBG1

    1 HMDB Compound for HBG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    1 DrugBank Compound for HBG1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Heme-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for HBG1 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aclacinomycin 79.7 2 8853898 (1), 8602880 (1)
    butyrate 77.8 28 9292546 (3), 7529873 (1), 14594506 (1), 18549621 (1) (see all 21)
    hydroxyurea 69.2 13 15985540 (2), 9668530 (1), 19657070 (1), 19914848 (1) (see all 8)
    alpha-aminobutyric acid 68.9 3 7527673 (1), 8704217 (1)
    benzidine 68.7 6 17957275 (1), 17355941 (1)
    isobutyramide 67.4 2 10575551 (1)
    porphobilinogen 59 7 9305615 (2), 8639908 (1), 14757314 (1), 8853898 (1) (see all 6)
    azathioprine 48.9 4 14594506 (1), 7527673 (1), 16608912 (1), 16131492 (1)
    aclarubicin 48.9 1 10449186 (1)
    phenylbutyrate 48.9 5 9668530 (1), 8937430 (1), 12393583 (1)



    HBG1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HBG1 gene: 
    NM_000559.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330597(uc001mah.1)
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HBG1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HBG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HBG1
    Primer
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    OriGene qPCR primer pairs and template standards for HBG1
    OriGene qSTAR qPCR primer pairs in human, mouse for HBG1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat HBG1
      QuantiTect SYBR Green Assays in human, mouse, rat HBG1
      QuantiFast Probe-based Assays in human, mouse, rat HBG1

    Selected AceView cDNA sequences (see all 50):

    CR625875 CR610392 CR626466 CR593357 CR602719 CR594576 CR626417 CR593826 
    CR607395 CR613883 AF110493 NM_000559 CR609361 CR603041 NM_000184 CR622267 
    CR604223 CR599317 X55657 CR613701 CR593022 CR615907 CR619706 CR595535 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HBG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCAGAGCT
    HBG1 Expression
    About this image


    HBG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Coronary Vessels
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 3 entries
             Primordial Germ Cells Allantois
             Allantois
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephros
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Bone Marrow
    HBG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HBG1 Protein Expression

    UniProtKB/Swiss-Prot: HBG1_HUMAN, P69891
    Tissue specificity: Red blood cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HBG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HBG1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hbb-bh15 hemoglobin Z, beta-like embryonic chain   --   7 (54.85 cM) 103841636 
    chicken
    (Gallus gallus)
    Aves HBB6
    HBE16
    (see all 4)
    Gallus gallus hemoglobin, epsilon 1 (HBE1), mRNA.
    (see all 4)
    70(a)
    69(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    1(193723743-193726040) ENSGALG00000028273
    1(193720895-193722856) ENSGALG00000022703
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    62(a)
    1 → many
    GL344018.1(38428-41710)
    zebrafish
    (Danio rerio)
    Actinopterygii hbaa16
    si:ch211-5k11.66
    (see all 8)
    si:ch211-5k11.6
    (see all 8)
    41(a)
    41(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    3(55951832-55957638) ENSDARG00000079078
    3(55945253-55946071) ENSDARG00000069735


    ENSEMBL Gene Tree for HBG1 (if available)
    TreeFam Gene Tree for HBG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HBG1 gene
    HBE12  HBG22  HBZ2  HBD2  HBA22  HBB2  HBQ12  HBA12  
    HBM2  
    13 SIMAP similar genes for HBG1 using alignment to 4 protein entries:     HBG1_HUMAN (see all proteins):
    HBG2    G-gamma    HBD/HBB    HBE1    HBD    HBB
    HBZ    HBA1    HBA2    HBM    HBQ1    CYGB
    MB

    HBG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HBG1 (see all 232)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2818606011,2
    Cpathogenic15185449(-) TTGACC/TAATAG 1 -- us2k10--------
    rs353789151,2
    Cpathogenic15185452(-) GCCTTA/GACCAA 1 -- us2k10--------
    rs353219131,2
    Cpathogenic15185530(-) CTTCCC/GCACAC 1 -- us2k10--------
    rs359832581,2
    Cpathogenic15185531(-) CCTTCC/TCCACA 1 -- us2k10--------
    rs357107271,2
    Cpathogenic15185533(-) CCCCTC/TCCCCA 1 -- us2k10--------
    rs346989071,2
    Cuntested15185211(-) AAGAT-/GCTGGAGG 1 -- cds10--------
    rs339248251,2,,4
    Cuntested15185264(-) CAGAGA/C/GAGGAC 3 K Q E mis10--------
    rs413221481,2
    Cuntested15185493(-) ACGGTC/TCCTGG 1 -- us2k10--------
    rs341539021,2
    Cuntested15185510(-) GCAAAC/TATCTG 1 -- us2k10--------
    rs346191941,2
    Cuntested15185537(-) GGGGCC/TCCTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HBG1 (5269313 - 5271122 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HBG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2648523CNV Deletion19546169
    esv2744059CNV Deletion23290073
    esv2671356CNV Deletion23128226
    nsv896929CNV Loss21882294
    esv5471CNV Loss19470904
    nsv896930CNV Gain21882294
    dgv194n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): HBG1
    Locus Specific Mutation Databases (LSDB): HBG1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HBG1
    DNA2.0 Custom Variant and Variant Library Synthesis for HBG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142200   
    OMIM disorders: 141749  
    Selected diseases for HBG1 (see all 24):    
    About MalaCards
    fetal hemoglobin quantitative trait locus 1    beta thalassemia    hereditary persistence of fetal hemoglobin    congenital hemolytic anemia
    delta-beta thalassemia    hereditary persistence of fetal hemoglobin - sickle cell disease    hemoglobin s beta-thalassemia    thalassemia
    hemoglobinopathy    sickle cell disease    alpha thalassemia    sickle cell anemia
    hereditary spherocytosis    hemolytic anemia    gastroenteritis    myelodysplastic syndromes
    sinusitis    lymphoblastic leukemia    leukemia    diabetes mellitus

    2 diseases from the University of Copenhagen DISEASES database for HBG1:
    Gastroenteritis     Thalassemia

    HBG1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HBG1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 83.5 7 2217202 (1), 8400240 (1), 11162141 (1), 7686501 (1) (see all 7)
    beta-thalassemia 83.4 24 16814578 (2), 7703040 (2), 10699179 (1), 10975440 (1) (see all 19)
    hemoglobinopathies 82.4 7 17699975 (1), 19958193 (1), 7579419 (1), 16814578 (1) (see all 6)
    sickle cell disease 80 13 12200360 (1), 16378095 (1), 17612629 (1), 11063260 (1) (see all 12)
    thalassemia 73.8 6 12200360 (1), 15534853 (1), 16787871 (1), 16338486 (1) (see all 6)
    alpha-thalassemia 60.4 3 7703040 (2), 18076350 (1)
    sickle cell trait 42.5 1 16683895 (1)
    anemia 40.2 2 10688844 (1), 9857233 (1)
    anemia severe 24.6 1 15931385 (1)
    hemolysis 20.7 3 16728274 (1)

    Genetic Association Database (GAD): HBG1
    Human Genome Epidemiology (HuGE) Navigator: HBG1 (3 documents)

    Export disorders for HBG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HBG1 gene, integrated from 10 sources (see all 369):
    (articles sorted by number of sources associating them with HBG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular analysis of gamma-globin promoters, HS-111 and 3'HS1, in beta-thalassemia intermedia patients associated with high levels of Hb F. (PubMed id 19958188)1, 4, 9 Hamid M....Karimipoor M. (Hemoglobin 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia. (PubMed id 11514664)1, 2 Kidd R.D.... Baker E.N. (Protein Sci. 2001)
    4. Hb F-Macedonia-I or alpha 2A gamma (2)2(NA2)His-->Gln. (PubMed id 7928382)1, 2 Plaseska D.... Efremov G.D. (Hemoglobin 1994)
    5. Gamma chain abnormalities and gamma-globin gene rearrangements in newborn babies of various populations. (PubMed id 1802881)1, 2 Huisman T.H.J.... Gu L.H. (Hemoglobin 1991)
    6. Hb F-Jiangsu, the first gamma chain variant with a valine->methionine substitution: alpha 2A gamma 2 134(H12)Val->Met. (PubMed id 1703137)1, 2 Plaseska D....Huisman T.H.J. (Hemoglobin 1990)
    7. A review of the molecular genetics of the human alpha-globin gene cluster. (PubMed id 2649166)1, 3 Higgs D.R....Weatherall D.J. (Blood 1989)
    8. Hb F-Fukuyama or A gamma T43(CD2)Asp-->Asn. (PubMed id 2467893)1, 2 Hidaka K.... Iwakawa G. (Hemoglobin 1989)
    9. Hb F-Baskent or alpha 2A gamma 128(H6)Ala-->Thr. (PubMed id 2454900)1, 2 Altay C....Huisman T.H.J. (Hemoglobin 1988)
    10. Hb F-Xin-Su or A gamma I73(E17)Asp-->His: a new slow-moving fetal hemoglobin variant. (PubMed id 2448269)1, 2 Ma M.... Huisman T.H.J. (Hemoglobin 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3047 HGNC: 4831 AceView: HBG2andHBG1 Ensembl:ENSG00000213934 euGenes: HUgn3047
    ECgene: HBG1 H-InvDB: HBG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HBG1 Pharmacogenomics, SNPs, Pathways
    HbVarhttp://globin.bx.psu.edu/cgi-bin/hbvar/query_vars3?mode=directlink&gene=HBG1

    (Patent information from GeneIP,
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    Patent Information for HBG1 gene:
    Search GeneIP for patents involving HBG1

    GeneCards and IP:
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