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HBG1 Gene

protein-coding GIFtS: 54

GC11M005226

hemoglobin, gamma A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Gamma-1-globin ^³
HBGA ^²
HBGR ^²
HSGGL1 ^²
PRO2979 ^²

Descriptions
A-gamma globin ^²
Hb F Agamma ^³
Hemoglobin gamma-1 chain ^³
Hemoglobin gamma-A chain ^², ³
gamma A hemoglobin ^²
gamma globin ^²
hemoglobin, gamma A ^²
hemoglobin, gamma, regulator of ^²

External Ids
HGNC: 4831¹
Entrez Gene: 3047²
UniProtKB: P69891³
Ensembl: ENSG00000213934⁷

Search outside databases for aliases for HBG1 gene

Previous GC identifers: GC11M006017 GC11M005571 GC11M005228 GC11M005215 GC11M005234

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HBG1:

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone

marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is

normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related

conditions, gamma chain production continues into adulthood. The two types of gamma chains differ

at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the

A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the

beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided

by RefSeq]

UniProtKB/Swiss-Prot: HBG1_HUMAN, P69891

Function: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains

Gene Wiki entry for HBG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HBG1 gene

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5

HBG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M005226: (about GC identifiers)

Start:	5,226,078 bp from pter
End:	5,227,693 bp from pter
Size:	1,616 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HBG1_HUMAN, P69891 (See protein sequence)

Recommended Name: Hemoglobin subunit gamma-1

Size: 147 amino acids; 16140 Da

Subunit: Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F). In the

case of deletions affecting one or more of the alpha chains the excess gamma chains form

homotetramers that exhibit neither Bohr effect nor heme-heme cooperativity (hemoglobin Bart's)

Developmental stage: Expressed until four or five weeks after birth

PDB structure from and Proteopedia :

1I3D (3D)

1I3E (3D)

Secondary accessions: P02096 P62027 Q96FH7

Post-translational modifications:

Acetylation of Gly-2 converts Hb F to the minor Hb F1¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000550.2

ENSEMBL proteins:

ENSP00000369606 ENSP00000327431

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for HBG1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Hemoglobin, fetal hemoglobin)
	Human Recombinant Proteins from Abnova (HBG1)

OriGene Purified Recombinant Human Protein: HBG1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005833	hemoglobin complex	IEA	--

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Antibodies for HBG1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Hemoglobin, fetal hemoglobin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HBG1)
	Novus Biologicals Antibodies for HBG1

Assays for HBG1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P69891

ProtoNet protein and cluster: P69891

2 Blocks protein families:

IPB001032 Leghaemoglobin

IPB002337 Beta haemoglobin signature

UniProtKB/Swiss-Prot: HBG1_HUMAN, P69891

Similarity: Belongs to the globin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HBG1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000559

Applied Biosystems Silencer® siRNAs for HBG1

Sigma-Aldrich siRNA for HBG1

Sigma-Aldrich shRNA for HBG1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HBG1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000559
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000559
untagged cDNA clone in CMV expression vector: NM_000559

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000559

UniProtKB/Swiss-Prot: HBG1_HUMAN, P69891

Function: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains

Genatlas biochemistry entry for HBG1:

globin,gamma A,fetal (A 136)

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005344	oxygen transporter activity	IEA	--
GO:0005515	protein binding	IPI	17353931
GO:0019825	oxygen binding	IEA	--
GO:0020037	heme binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for HBG1

5/57 Interacting proteins for HBG1 (ENSP00000369606³ P69891¹) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GABARAPL2	P60520¹	EBI-1056789, EBI-720116
SUCLG2	ENSP00000307432³	STRING (score=.99)
KLF1	ENSP00000264834³	STRING (score=.977)
KLF11	ENSP00000307023³	STRING (score=.976)
NGB	ENSP00000298352³	STRING (score=.971)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0015671	oxygen transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HBG1
10/14 Novoseek chemical compound relationships for HBG1 gene (see all 14 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
aclacinomycin	79.99	2	8853898 (1), 8602880 (1)
alpha-aminobutyric acid	69.71	3	7527673 (1), 8704217 (1)
benzidine	63.37	6	17957275 (1), 17355941 (1)
porphobilinogen	59.93	7	9305615 (2), 8639908 (1), 14757314 (1), 8853898 (1) (see all 6)
5-aminolevulinic acid	37.80	1	15958056 (1)
fatty acid	21.11	6	7579419 (2), 12687749 (1), 11342457 (1), 12393583 (1)
glyceraldehyde 3-phosphate	21.02	2	12738678 (1), 12864948 (1)
leucine	8.33	1	8537230 (1)
zinc	3.66	3	7624127 (1), 15537646 (1), 16131492 (1)
iron	0.14	4	8318917 (1), 8874195 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HBG1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000559

Sigma-Aldrich siRNA for HBG1

Sigma-Aldrich shRNA for HBG1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000559

REFSEQ mRNAs for HBG1 gene:

NM_000559.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000559

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000559
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000559
                                 untagged cDNA clone in CMV expression vector: NM_000559

Additional cDNA sequence:

BC010913.1 BC010914.1 BC020719.1 CR593382.1 CR594720.1 CR596479.1 CR604256.1 CR608640.1

CR608786.1 CR609411.1 CR614139.1 CR619706.1 CR619879.1 CR619938.1 CR620360.1 CR621032.1

CR622267.1 CR625875.1 CR626236.1 CR626417.1 CR626466.1 V00512.1 X55655.1

24/27 DOTS entries (see all 27 ):

DT.95221675 DT.95186195 DT.98083189 DT.91786228 DT.91790886 DT.100890392 DT.95230852 DT.95298167

DT.100044348 DT.95180915 DT.100774732 DT.75131589 DT.95371917 DT.91866943 DT.120723250 DT.95233683

DT.95323075 DT.120723406 DT.100806001 DT.87014143 DT.95092533 DT.95345553 DT.92413533 DT.120723246

24/50 AceView cDNA sequences (see all 50 ):

CR602897 CR613883 CR593470 CR593022 CR610392 CR625875 CR614139 CR607395

NM_000184 NM_000559 CR593357 CR599317 CR613701 CR593826 CR595535 CR622267

CR594576 X55657 CR626417 CR609361 CR603041 CR604223 CR615907 CR595029

highest scoring ESTs for HBG1:

AI114668 AI174737 BC010913 BI909241 BX506698 N80535 AA089607 AA094889 AA095627 AA294906

Unigene Cluster for HBG1:

Hemoglobin, gamma A

Hs.712539 [show with all ESTs]

Unigene Representative Sequence: BI909241

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000380256 ENST00000330597

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HBG1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HBG1

¹ / ² / ³

7 probe-sets matching HBG1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38585_at²^{, 3}	U95-A	2	1.00	0.50	1.00	1.00	M91036	0.20	0.50	0.38	1
204848_x_at²^{, 3}	U133-A	5	1.00	0.50	--	--	NM_000559	0.40	0.50	0.45	1
204419_x_at²^{, 3}	U133-A	5	1.00	0.46	--	--	NM_000184	0.20	0.17	0.18	2
213515_x_at²^{, 3}	U133-A	5	1.00	0.43	--	--	AI133353	0.20	0.25	0.23	2
204848_x_at²	U133Plus2	5	1.00	0.50	--	--	--	--	--	--	--
204419_x_at²	U133Plus2	5	1.00	0.46	--	--	--	--	--	--	--
213515_x_at²	U133Plus2	5	1.00	0.43	--	--	--	--	--	--	--

GeneDecks HBG1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATGCAGAGCT

SOURCE GeneReport for Unigene cluster: Hs.712539
Expression variation in blood from EXPOLDB for HBG1
UniProtKB/Swiss-Prot: HBG1_HUMAN, P69891
Tissue specificity: Red blood cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HBG1 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HBG1¹	--	hemoglobin, gamma A	79.59(n) 76.87(a)	485255 XM_542373.2 XP_542373.2
chimpanzee (Pan troglodytes)	HBG1¹	--	hemoglobin, gamma A	98.87(n) 98.64(a)	450979 XM_001161863.1 XP_001161863.1
cow (Bos taurus)	HBE4¹	--	hemoglobin, beta, epsilon 4	79.37(n) 74.15(a)	513108 NM_001014910.1 NP_001014910.1
rat (Rattus norvegicus)	Hbg1¹	--	hemoglobin, gamma A	78(n) 74.15(a)	94164 NM_172093.1 NP_742090.1
mouse (Mus musculus)	Hbb-bh1¹	--	hemoglobin Z, beta-like embryonic chain	79.37(n) 75.51(a)	15132 NM_008219.2 NP_032245.1

About this table Species with no ortholog for HBG1

ENSEMBL Gene Tree for HBG1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HBG1 gene

HBB² HBE1² HBG2² CYGB² HBD²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/149 NCBI SNPs in HBG1 are shown (see all 149 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 57)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs916111^1,2	A,C,F,H,O	5225919(-)	`TTTTGT/ATGAGC`	1	--	ng5¹		16		NS EA MN EU WA NA	2642
	rs2855039^1,2	A,C,F,H	5228247(-)	`TCACTG/ACACTA`	1	--	ng3¹		4		EU EA WA	420
	rs6578592^1,2	A,C,F,H	5225716(+)	`CCTTCA/CTTAAG`	1	--	ng5¹		12		EU EA WA NA	1156
--	rs2855036^1,2	A,C	5229258(-)	`tagacA/Gcaagg`	1	--	ng3¹		0	--	--	--	--
--	rs1061234^1,2	C,F	5227262(-)	`TGCCAT/CAAAGC`	1	I/T	mis¹		1		MN	184
	rs1143541^1,2	C,H	5225906(-)	`ATAAAA/TGCAGT`	1	--	ng5¹		3		EU EA	298
--	rs11827654^1,2	C	5229097(+)	`ccttcA/Gaaatt`	1	--	ng3¹		0	--	--	--	--
--	rs33947112^1,2	C	5227248(-)	`TGGATA/G/TATCTC`	2	D/N D/Y	mis¹		0	--	--	--	--
--	rs7941835^1,2	C	5227679(+)	`TGAAGC/GGTGCT`	1	--	ng3¹		0	--	--	--	--
--	rs33924825^1,2	C	5227592(-)	`CAGAGA/C/GAGGAC`	2	E/K E/Q	mis¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for HBG1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 142200 disorders: 141749

UniProtKB/Swiss-Prot: HBG1_HUMAN, P69891

Some gamma variants can cause severe jaundice and cyanosis in premature and new born

babies

10/14 Novoseek disease relationships for HBG1 gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroleukemia	84.00	7	2217202 (1), 8400240 (1), 11162141 (1), 7686501 (1) (see all 7)
beta-thalassemia	82.36	22	16814578 (2), 7703040 (2), 10699179 (1), 10975440 (1) (see all 17)
hemoglobinopathies	82.33	6	17699975 (1), 7579419 (1), 16814578 (1), 9883803 (1) (see all 5)
sickle cell disease	79.89	13	12200360 (1), 16378095 (1), 17612629 (1), 11063260 (1) (see all 12)
thalassemia	74.38	6	12200360 (1), 15534853 (1), 16787871 (1), 16338486 (1) (see all 6)
alpha-thalassemia	58.31	3	7703040 (2), 18076350 (1)
sickle cell trait	44.27	1	16683895 (1)
anemia	40.65	2	10688844 (1), 9857233 (1)
anemia severe	26.36	1	15931385 (1)
hemolysis	22.40	3	16728274 (1)

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Human Gene Mutation Database: HBG1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/319 PubMed articles for HBG1 gene (see all 319 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia. (PubMed id 11514664)^{3, 4} Kidd R.D.... Baker E.N. (2001)
Hb F-Macedonia-I or alpha 2A gamma (2)2(NA2)His-->Gln. (PubMed id 7928382)^{3, 4} Plaseska D.... Efremov G.D. (1994)
Gamma chain abnormalities and gamma-globin gene rearrangements in newborn babies of various populations. (PubMed id 1802881)^{3, 4} Huisman T.H.J.... Gu L.H. (1991)
Hb F-Jiangsu, the first gamma chain variant with a valine->methionine substitution: alpha 2A gamma 2 134(H12)Val->Met. (PubMed id 1703137)^{3, 4} Plaseska D....Huisman T.H.J. (1990)
A review of the molecular genetics of the human alpha-globin gene cluster. (PubMed id 2649166)^{2, 3} Higgs D.R....Weatherall D.J. (1989)
Hb F-Fukuyama or A gamma T43(CD2)Asp-->Asn. (PubMed id 2467893)^{3, 4} Hidaka K.... Iwakawa G. (1989)
Hb F-Baskent or alpha 2A gamma 128(H6)Ala-->Thr. (PubMed id 2454900)^{3, 4} Altay C....Huisman T.H.J. (1988)
Hb F-Xin-Su or A gamma I73(E17)Asp-->His: a new slow-moving fetal hemoglobin variant. (PubMed id 2448269)^{3, 4} Ma M.... Huisman T.H.J. (1987)
Hb F-Xinjiang or A gamma T25(B7)Gly-->Arg: a new slow-moving unstable fetal hemoglobin variant. (PubMed id 2448268)^{3, 4} Hu H. and Ma M. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3047	HGNC: 4831	AceView: HBG2andHBG1	Ensembl:ENSG00000213934	euGenes: HUgn3047
ECgene: HBG1	H-InvDB: HBG1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
HbVar	http://globin.bx.psu.edu/cgi-bin/hbvar/query_vars3?mode=directlink&gene=HBG1

Licensable Technologies for HBG1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HBG1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HBG1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HBG1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Proteins for HBG1
	Lentivirus-delivered shRNAs for HBG1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Antibodies (HBG1)
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	Antibodies (Hemoglobin, fetal hemoglobin)

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	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for HBG1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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HBG1 Gene at Home site.
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HBG1 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for HBG1

Summaries
for HBG1

Genomic Location
for HBG1

Proteins
for HBG1

Protein Domains/
Families
for HBG1

Gene Function
for HBG1

Pathways & Interactions
for HBG1

Drugs & Compounds
for HBG1

Transcripts
for HBG1

Expression
for HBG1

Orthologs
for HBG1

Paralogs
for HBG1

SNPs/Variants
for HBG1

Disorders & Mutations
for HBG1

Medical News
for HBG1

Publications
for HBG1

Search for HBG1

Genome Databases showing HBG1

Other Databases showing HBG1

Specialized Databases showing HBG1

Licensable Technologies
for HBG1

Services
for HBG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HBG1 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor HBG1

Summariesfor HBG1

Genomic Locationfor HBG1

Proteinsfor HBG1

Protein Domains/Familiesfor HBG1

Gene Functionfor HBG1

Pathways & Interactionsfor HBG1

Drugs & Compoundsfor HBG1

Transcriptsfor HBG1

Expression for HBG1

Orthologsfor HBG1

Paralogsfor HBG1

SNPs/Variantsfor HBG1

Disorders & Mutationsfor HBG1

Medical Newsfor HBG1

Publicationsfor HBG1

Search for HBG1

Genome Databases showing HBG1

Other Databases showing HBG1

Specialized Databases showing HBG1

Licensable Technologiesfor HBG1

Servicesfor HBG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HBG1

Summaries
for HBG1

Genomic Location
for HBG1

Proteins
for HBG1

Protein Domains/
Families
for HBG1

Gene Function
for HBG1

Pathways & Interactions
for HBG1

Drugs & Compounds
for HBG1

Transcripts
for HBG1

Expression
for HBG1

Orthologs
for HBG1

Paralogs
for HBG1

SNPs/Variants
for HBG1

Disorders & Mutations
for HBG1

Medical News
for HBG1

Publications
for HBG1

Licensable Technologies
for HBG1

Services
for HBG1