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HBEGF Gene

protein-coding GIFtS: 57

GC05M139694

heparin-binding EGF-like growth factor
(Previous name: diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: HEGFL, DTS, DTR)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DTR ^², ³, ⁵
DTS ^², ³
DTSF ^², ⁵
HEGFL ^², ³, ⁵

Descriptions
diphtheria toxin receptor (heparin-binding EGF-like growth factor) ^²
diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) ^¹, ²
heparin-binding EGF-like growth factor ^²
heparin-binding epidermal growth factor ^²

External Ids
HGNC: 3059¹
Entrez Gene: 1839²
UniProtKB: Q99075³
Ensembl: ENSG00000113070⁷

Search outside databases for aliases for HBEGF gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HBEGF_HUMAN, Q99075

Function: May be involved in macrophage-mediated cellular proliferation. It is mitogenic for

fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with

higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF.

Also acts as a diphtheria toxin receptor

Gene Wiki entry for HBEGF (Heparin-binding_EGF-like_growth_factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HBEGF gene

Entrez Gene cytogenetic band: 5q23 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q23

HBEGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M139694: (about GC identifiers)

Start:	139,692,612 bp from pter
End:	139,706,359 bp from pter
Size:	13,748 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HBEGF_HUMAN, Q99075 (See protein sequence)

Recommended Name: Proheparin-binding EGF-like growth factor precursor

Size: 208 amino acids; 23067 Da

Subcellular location: Heparin-binding EGF-like growth factor: Secreted, extracellular space.

Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor

Subcellular location: Proheparin-binding EGF-like growth factor: Cell membrane; Single-pass type I

membrane protein

PDB structures from and Proteopedia :

1XDT (3D)

Post-translational modifications:

Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74

have been tested and found to be biologically active¹

O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests

mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001936.1

ENSEMBL proteins:

ENSP00000230990

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for HBEGF
	R&D Systems Recombinant & Natural Proteins for HBEGF (HB-EGF)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HB EGF)
	Human Recombinant Proteins from Abnova (HBEGF)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	15389565
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	15389565
GO:0009986	cell surface	NAS	15289334

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Antibodies for HBEGF:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HBEGF
	R&D Systems Antibodies for HBEGF (HB-EGF)
	Antibodies from Abcam (HB EGF), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HBEGF)
	Novus Biologicals Antibodies for HBEGF

Assays for HBEGF:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for HBEGF (HB-EGF) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q99075

ProtoNet protein and cluster: Q99075

2 Blocks protein families:

IPB001336 Type I EGF signature

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: HBEGF_HUMAN, Q99075

Similarity: Contains 1 EGF-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HBEGF)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HBEGF)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001945

Applied Biosystems Silencer® siRNAs for HBEGF

Sigma-Aldrich siRNA and siRNA Panels for HBEGF

Sigma-Aldrich shRNA for HBEGF

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HBEGF
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001945
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001945
untagged cDNA clone in CMV expression vector: NM_001945

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001945

UniProtKB/Swiss-Prot: HBEGF_HUMAN, Q99075

Function: May be involved in macrophage-mediated cellular proliferation. It is mitogenic for

fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with

higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF.

Also acts as a diphtheria toxin receptor

11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Hbegf):

	growth/size	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	muscle	normal	respiratory system	skeleton
skin/coat/nails

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005154	epidermal growth factor receptor binding	TAS	10749879
GO:0008083	growth factor activity	IEA	--
GO:0008201	heparin binding	IMP	8300582

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for HBEGF (Your Favorite Gene powered by Ingenuity)

Neuregulin Signaling
IL-8 Signaling

GeneDecks HBEGF for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for HBEGF

5/36 Interacting proteins for HBEGF (ENSP00000230990³) via UniProtKB, MINT, and/or STRING (see all 36 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EGFR	ENSP00000275493³	STRING (score=.997)
ERBB4	ENSP00000342235³	STRING (score=.985)
CD9	ENSP00000009180³	STRING (score=.978)
ADAM17	ENSP00000309968³	STRING (score=.973)
ADAM10	ENSP00000260408³	STRING (score=.96)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	1840698
GO:0007173	epidermal growth factor receptor signaling pathway	IEA	--
GO:0007517	muscle development	TAS	8347598
GO:0008016	regulation of heart contraction	IEA	--
GO:0035313	wound healing, spreading of epidermal cells	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HBEGF
10/43 Novoseek chemical compound relationships for HBEGF gene (see all 43 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diphtheria toxin	71.19	6	7646457 (3), 8379922 (1)
heparan sulfate	67.93	38	8578521 (1), 10037743 (1), 9438425 (1), 11320054 (1) (see all 19)
hcec	64.34	6	18495812 (1), 15277479 (1), 16799022 (1)
tyrosine	60.20	42	9334263 (2), 11798972 (2), 9110152 (1), 10579352 (1) (see all 34)
chondroitin sulfate	52.46	8	1306684 (1), 16175577 (1), 11421350 (1), 12634322 (1) (see all 6)
thymidine	47.64	11	10544013 (1), 10751853 (1), 8077234 (1), 9115748 (1) (see all 11)
chlorate	47.44	1	8609052 (1)
12-o-tetradecanoylphorbol 13-acetate	42.33	31	9244191 (3), 16557002 (3), 7579712 (1), 8060360 (1) (see all 7)
v2o5	39.17	4	11159045 (1)
phosphatidylinositol	34.03	4	18925469 (1), 8626392 (1), 14576062 (1), 16556679 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HBEGF)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HBEGF)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001945

Sigma-Aldrich siRNA and siRNA Panels for HBEGF

Sigma-Aldrich shRNA for HBEGF

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001945

REFSEQ mRNAs for HBEGF gene:

NM_001945.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001945

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001945
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001945
                                 untagged cDNA clone in CMV expression vector: NM_001945

Additional cDNA sequence:

AK222688.1 AK307310.1 AK313202.1 BC033097.1 M60278.1

4 DOTS entries:

DT.117292 DT.86851568 DT.99971739 DT.95270771

24/154 AceView cDNA sequences (see all 154 ):

CB159853 AI129680 BI910684 CA435723 BQ720838 BF594452 NM_001945 BF592951

AA343828 AI697686 D55114 AA425157 BQ416757 M60278 AI052201 AA410374

W39595 BC033097 CA433350 BM762311 BM761883 C04884 H46786 BX113822

highest scoring ESTs for HBEGF:

M60278 AA161219 AA601605 AA857693 AA894749 AI023180 AI253252 AI697686 AI871611 AI971664

Unigene Cluster for HBEGF:

Heparin-binding EGF-like growth factor

Hs.799 [show with all ESTs]

Unigene Representative Sequence: NM_001945

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000230990

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HBEGF expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HBEGF

¹ / ² / ³

5 probe-sets matching HBEGF gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38037_at²^{, 3}	U133-A	1	1.00	1.00	1.00	1.00	M60278	1.00	1.00	1.00	1
38037_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M60278	1.00	1.00	1.00	1
203821_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001945	0.60	1.00	0.82	1
38037_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203821_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HBEGF for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.799

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HBEGF gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HBEGF¹	--	heparin-binding EGF-like growth factor	89.42(n) 88.94(a)	607007 XM_843521.1 XP_848614.1
chimpanzee (Pan troglodytes)	HBEGF¹	--	heparin-binding EGF-like growth factor	99.68(n) 99.52(a)	735979 XM_001137119.1 XP_001137119.1
cow (Bos taurus)	HBEGF¹	--	heparin-binding EGF-like growth factor	89.26(n) 87.98(a)	522921 XM_601210.3 XP_601210.2
rat (Rattus norvegicus)	Hbegf¹	--	heparin-binding EGF-like growth factor	82.85(n) 81.73(a)	25433 NM_012945.1 NP_037077.1
mouse (Mus musculus)	Hbegf^{1, 5}	18 (15.00 cM)⁵	heparin-binding EGF-like growth factor^{1, 5}	82.53(n)¹ 80.77(a)¹	15200¹ NM_010415.1¹ NP_034545.1¹ AK145548⁵ AK160575⁵ (see all 17)

About this table Species with no ortholog for HBEGF

ENSEMBL Gene Tree for HBEGF

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HBEGF gene

AREGB² AREG²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/110 NCBI SNPs in HBEGF are shown (see all 110 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 45)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs13385^1,2	A,C,F,H,O	139693062(-)	`CCCTGC/TCAAGT`	1	--	ut3¹ ese³		19	MN EA NS NA EU WA	3176
	rs4150196^1,2	A,C,F,H	139706825(-)	`TGATAA/GATGAA`	1	--	ng3¹		14	NS EU EA WA NA	1350
	rs7268^1,2	A,C,F,H	139692734(-)	`TGAAGG/TTATGC`	1	--	ut3¹		23	NS MN EU EA WA NA	2152
	rs2282802^1,2	A,C,F,H	139692423(-)	`cttgcT/Ctgagg`	1	--	ng5¹		8	NS EU EA WA NA	676
	rs4150194^1,2	C,F,H	139707942(-)	`ATACTC/GATCAC`	1	--	ng3¹		8	NS EU EA WA NA	690
	rs4150238^1,2	C,F,H	139693866(-)	`ATGGTA/GTCTGG`	1	--	ut3¹ ese³		17	NS EU EA WA NA	1492
	rs3776089^1,2	C,F,H	139707444(+)	`GGTCAA/GTCTGG`	1	--	ng3¹		22	NS EU EA WA NA	1988
--	rs1042184^1,2	C,F,H	139706145(-)	`GCCGCC/TGCTTC`	1	--	ut5¹ ese³		9	NS MN EU EA WA NA	848
	rs4150195^1,2	C,F,H	139707477(-)	`CCTAGG/ATTACT`	1	--	ng3¹		8	NS EU EA WA NA	688
	rs4150242^1,2	C,F,H	139692872(-)	`TTAGCA/CAAGCA`	1	--	ut3¹		12	NS NA EU EA WA	878

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HapMap Linkage Disequilibrium images for HBEGF (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 126150

10/88 Novoseek disease relationships for HBEGF gene (see all 88 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diphtheria	79.73	130	1939100 (3), 7980519 (3), 7622504 (3), 10547351 (3) (see all 63)
cystitis bacterial	55.85	3	9334654 (2), 11378043 (1)
bladder diseases	49.77	1	9334654 (1)
tumors	42.80	99	1279186 (4), 15289334 (4), 15313912 (4), 16630129 (3) (see all 53)
gastric cancer	39.74	23	8621250 (4), 19218109 (3), 11920609 (2), 14764442 (1) (see all 10)
pancreatic cancer	38.15	24	8060360 (5), 15817123 (3), 10505759 (2), 15249209 (1) (see all 7)
carcinoma embryonal	38.13	7	11169062 (1), 19152444 (1), 10902971 (1), 12507292 (1) (see all 7)
cancer	36.26	40	18023415 (2), 12686563 (2), 16630129 (2), 8784471 (2) (see all 28)
intestinal ischemia	34.49	9	11890738 (2), 18558204 (1), 11781977 (1), 10600353 (1) (see all 5)
bladder cancer	30.55	10	16166300 (2), 17394193 (2), 17274952 (1), 15228094 (1) (see all 5)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/704 PubMed articles for HBEGF gene (see all 704 ):

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein. (PubMed id 1556128)^{1, 3, 4} Higashiyama S.... Klagsbrun M. (1992)
Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. (PubMed id 7836353)^{1, 3, 4} Mitamura T.... Mekada E. (1995)
Mouse chromosomal location of three EGF receptor ligands: amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF (Hegfl). (PubMed id 7590736)^{1, 2, 3} Pathak B.G....Lee D.C. (1995)
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. (PubMed id 1840698)^{1, 3, 4} Higashiyama S.... Klagsbrun M. (1991)
Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor. (PubMed id 9659904)^{1, 3, 4} Louie G.V.... Choe S. (1997)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)^{3, 4} Schmutz J.... Rubin E.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Dual source and target of heparin-binding EGF-like growth factor during the onset of implantation in the hamster. (PubMed id 12163414)^{2, 3} Wang X....Paria B.C. (2002)
Heparin-binding EGF-like growth factor is an early response gene to chemotherapy and contributes to chemotherapy resistance. (PubMed id 17001310)^{1, 3} Wang F....Cusack J.C. (2007)
The chemotherapeutic agent VP16 increases the stability of HB-EGF mRNA by a mechanism involving the 3'-UTR. (PubMed id 16996055)^{1, 3} Sorensen B.S....Nexo E. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1839	HGNC: 3059	AceView: DTR	Ensembl:ENSG00000113070	euGenes: HUgn1839
ECgene: HBEGF	H-InvDB: HBEGF

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for HBEGF	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/dtr/

Licensable Technologies for HBEGF
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HBEGF:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HBEGF-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HBEGF		Antibodies for HBEGF
	Explore super-pooled esiRNAs		Proteins for HBEGF
	Lentivirus-delivered shRNAs for HBEGF		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HBEGF)
	Antibodies (HBEGF)
	Chimera RNAi (HBEGF)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (HB EGF)
	Antibodies (HB EGF)

Search OriGene for HBEGF

Search Tocris compounds for HBEGF

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HBEGF

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
HBEGF Gene at Home site.
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HBEGF Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for HBEGF

Summaries
for HBEGF

Genomic Location
for HBEGF

Proteins
for HBEGF

Protein Domains/
Families
for HBEGF

Gene Function
for HBEGF

Pathways & Interactions
for HBEGF

Drugs & Compounds
for HBEGF

Transcripts
for HBEGF

Expression
for HBEGF

Orthologs
for HBEGF

Paralogs
for HBEGF

SNPs/Variants
for HBEGF

Disorders & Mutations
for HBEGF

Medical News
for HBEGF

Publications
for HBEGF

Search for HBEGF

Genome Databases showing HBEGF

Other Databases showing HBEGF

Specialized Databases showing HBEGF

Licensable Technologies
for HBEGF

Services
for HBEGF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HBEGF Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor HBEGF

Summariesfor HBEGF

Genomic Locationfor HBEGF

Proteinsfor HBEGF

Protein Domains/Familiesfor HBEGF

Gene Functionfor HBEGF

Pathways & Interactionsfor HBEGF

Drugs & Compoundsfor HBEGF

Transcriptsfor HBEGF

Expression for HBEGF

Orthologsfor HBEGF

Paralogsfor HBEGF

SNPs/Variantsfor HBEGF

Disorders & Mutationsfor HBEGF

Medical Newsfor HBEGF

Publicationsfor HBEGF

Search for HBEGF

Genome Databases showing HBEGF

Other Databases showing HBEGF

Specialized Databases showing HBEGF

Licensable Technologiesfor HBEGF

Servicesfor HBEGF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HBEGF

Summaries
for HBEGF

Genomic Location
for HBEGF

Proteins
for HBEGF

Protein Domains/
Families
for HBEGF

Gene Function
for HBEGF

Pathways & Interactions
for HBEGF

Drugs & Compounds
for HBEGF

Transcripts
for HBEGF

Expression
for HBEGF

Orthologs
for HBEGF

Paralogs
for HBEGF

SNPs/Variants
for HBEGF

Disorders & Mutations
for HBEGF

Medical News
for HBEGF

Publications
for HBEGF

Licensable Technologies
for HBEGF

Services
for HBEGF