Aliases for HBD Gene
External Ids for HBD Gene
Previous GeneCards Identifiers for HBD Gene
The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia. [provided by RefSeq, Jul 2008]
GeneCards Summary for HBD Gene
HBD (Hemoglobin Subunit Delta) is a Protein Coding gene. Diseases associated with HBD include Hemoglobin Lepore-Beta-Thalassemia Syndrome and Fetal Hemoglobin Quantitative Trait Locus 1. Among its related pathways are Factors involved in megakaryocyte development and platelet production and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is HBB.
UniProtKB/Swiss-Prot for HBD Gene
Involved in oxygen transport from the lung to the various peripheral tissues.