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HAVCR2 Gene

protein-coding   GIFtS: 54
GCID: GC05M156512

Hepatitis A Virus Cellular Receptor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hepatitis A Virus Cellular Receptor 21 2     T-Cell Membrane Protein 32 3
TIM32 3 5     KIM-32
T-Cell Immunoglobulin Mucin Family Member 31 2     Tim-32
HAVcr-22 3     Kidney Injury Molecule-32
TIMD-32 3     T Cell Immunoglobulin Mucin 32
TIMD32 3     T Cell Immunoglobulin Mucin-32
T-Cell Immunoglobulin And Mucin Domain-Containing Protein 32 3     TIM-33
T-Cell Immunoglobulin Mucin Receptor 32 3     

External Ids:    HGNC: 184371   Entrez Gene: 848682   Ensembl: ENSG000001350777   OMIM: 6066525   UniProtKB: Q8TDQ03   

Export aliases for HAVCR2 gene to outside databases

Previous GC identifers: GC05M157063 GC05M156448 GC05M156493 GC05M156445 GC05M151601


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAVCR2 Gene:
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins.
CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine
secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type
hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections
and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that
regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes
immunological tolerance. (provided by RefSeq, Sep 2011)

GeneCards Summary for HAVCR2 Gene:
HAVCR2 (hepatitis A virus cellular receptor 2) is a protein-coding gene. Diseases associated with HAVCR2 include dendritic cell thymoma, and prostatic adenoma. An important paralog of this gene is HAVCR1.

UniProtKB/Swiss-Prot: HAVR2_HUMAN, Q8TDQ0
Function: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune
responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9

Gene Wiki entry for HAVCR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HAVCR2 gene promoter:
         HFH-3   AP-2rep   C/EBPbeta   XBP-1   Roaz   GATA-2   FOXI1   FOXJ2 (long isoform)   HFH-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAVCR2 promoter sequence
   Search Chromatin IP Primers for HAVCR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAVCR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q34

HAVCR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAVCR2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M156512:  view genomic region     (about GC identifiers)

Start:
156,512,843 bp from pter      End:
156,569,880 bp from pter
Size:
57,038 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HAVR2_HUMAN, Q8TDQ0 (See protein sequence)
Recommended Name: Hepatitis A virus cellular receptor 2 precursor  
Size: 301 amino acids; 33394 Da
Secondary accessions: B2RAY2 Q8WW60 Q96K94
Alternative splicing: 2 isoforms:  Q8TDQ0-1   Q8TDQ0-2   

Explore the universe of human proteins at neXtProt for HAVCR2: NX_Q8TDQ0

Explore proteomics data for HAVCR2 at MOPED

Post-translational modifications: 

  • O-glycosylated with core 1 or possibly core 8 glycans1
  • Glycosylation2 at Thr145, Asn172
  • Modification sites at PhosphoSitePlus

  • See HAVCR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116171.3  
    ENSEMBL proteins: 
     ENSP00000312002   ENSP00000430873   ENSP00000430328  

    HAVCR2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HAVCR2
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    Novus Biologicals HAVCR2 Proteins
    Novus Biologicals HAVCR2 Lysate
    Sino Biological Recombinant Protein for HAVCR2
    Sino Biological Cell Lysate for HAVCR2
    ProSpec Recombinant Protein for HAVCR2
    Cloud-Clone Corp. Proteins for HAVCR2

    HAVCR2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HAVCR2
    R&D Systems Antibodies for HAVCR2 (TIM-3)
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    Novus Biologicals HAVCR2 Antibodies
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    LSBio Antibodies in human, mouse, rat for HAVCR2

    HAVCR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for HAVCR2
    Cloud-Clone Corp. CLIAs for HAVCR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8TDQ0

    ProtoNet protein and cluster: Q8TDQ0

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: HAVR2_HUMAN, Q8TDQ0
    Similarity: Belongs to the immunoglobulin superfamily. TIM family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    HAVCR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HAVR2_HUMAN, Q8TDQ0
    Function: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune
    responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    HAVCR2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HAVCR2:
     Decreased G3BP1 protein expres  Increased cilium length after  

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Havcr2):
     cellular  growth/size/body  hematopoietic system  immune system  mortality/aging 

    HAVCR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Havcr2tm1Tbs for HAVCR2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAVCR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HAVCR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAVCR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAVCR2

    miRNA
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    Block miRNA regulation of human, mouse, rat HAVCR2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate HAVCR2:
    hsa-miR-593 hsa-miR-330-5p hsa-miR-326 hsa-miR-3182 hsa-miR-103a-2* hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidHAVCR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HAVCR2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: HAVCR2 (NM_032782)
    Sino Biological Human cDNA Clone for HAVCR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAVCR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAVCR2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAVCR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HAVR2_HUMAN, Q8TDQ0: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    HAVCR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including HAVCR2: 
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HAVCR2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HAVCR2 (HAVR2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HAVCR2 gene: 
    NM_032782.4  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307851(uc003lwk.2) ENST00000522593 ENST00000524219 ENST00000521665
    ENST00000522902(uc003lwl.3) ENST00000517358
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate HAVCR2:
    hsa-miR-593 hsa-miR-330-5p hsa-miR-326 hsa-miR-3182 hsa-miR-103a-2* hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidHAVCR2 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for HAVCR2
    OriGene qSTAR qPCR primer pairs in human, mouse for HAVCR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HAVCR2
      QuantiTect SYBR Green Assays in human, mouse, rat HAVCR2
      QuantiFast Probe-based Assays in human, mouse, rat HAVCR2

    Selected AceView cDNA sequences (see all 51):

    BP340002 AA664217 BM923617 AI202037 CA307836 BI906710 CD710266 BQ581620 
    AF450242 AF450243 BX417090 BM505682 BG545730 BC020843 BP345570 BU789118 
    AJ705624 AY069944 CB155731 AW025572 BC063431 AK130144 CD641016 AU279844 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HAVCR2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:        -     -                                             
    SP2:        -     -                 -                           
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for HAVCR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HAVCR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGCCTGC
    HAVCR2 Expression
    About this image

    HAVCR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HAVCR2 Protein Expression

    UniProtKB/Swiss-Prot: HAVR2_HUMAN, Q8TDQ0
    Tissue specificity: T-helper type 1 lymphocyte (Th1)-specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HAVCR2: 
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HAVCR2
    OriGene qSTAR qPCR primer pairs in human, mouse for HAVCR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HAVCR2
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    QuantiFast Probe-based Assays in human, mouse, rat HAVCR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAVCR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HAVCR2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Havcr21 , 5 hepatitis A virus cellular receptor 21, 5 74.64(n)1
    66.79(a)1
      11 (27.90 cM)5
    1712851  NM_134250.21  NP_599011.21 
     464549355 
    chicken
    (Gallus gallus)
    Aves HAVCR16
    hepatitis A virus cellular receptor 1 precursor
    25(a)
    1 → many
    13(10778915-10785137)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    2(a)
    many ↔ many
    GL343205.1(2551432-2551587)
    zebrafish
    (Danio rerio)
    Actinopterygii timd46
    T-cell immunoglobulin and mucin domain containing ...
    25(a)
    1 → many
    21(28485046-28494504) ENSDARG00000077257


    ENSEMBL Gene Tree for HAVCR2 (if available)
    TreeFam Gene Tree for HAVCR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HAVCR2 gene
    HAVCR12  TIMD42  
    1 SIMAP similar gene for HAVCR2 using alignment to 3 protein entries:     HAVR2_HUMAN (see all proteins):
    HAVCR1

    HAVCR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HAVCR2 (see all 637)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs361713021,2
    C--156512640(+) CACAAC/AAGCCA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs352268561,2
    C,F--156514454(+) GAAAT-/AGCAAT 1 -- int14Minor allele frequency- A:0.50NA CSA 8
    rs1133126161,2
    C,F--156514752(+) TCTACC/TAAACA 1 -- int13Minor allele frequency- T:0.40CSA 5
    rs2013892641,2
    C--156516547(+) AAAAA-/ACAACA 1 -- int10--------
    rs113658101,2
    C--156516548(+) AAAAA-/ACAACA 1 -- int1 trp31Minor allele frequency- A:0.00NA 2
    rs1135604721,2
    C,F--156516558(+) AAAAAC/AAACAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1123091741,2
    C,F--156518325(+) GCGGCG/ACATGC 1 -- int13Minor allele frequency- A:0.40CSA 5
    rs77263261,2
    C,H--156519685(+) ctcccG/Agcctc 1 -- int11Minor allele frequency- A:0.00NA 2
    rs77057241,2
    C,H--156519686(+) tcccaA/Gcctca 1 -- int11Minor allele frequency- G:0.00NA 2
    rs724148821,2
    C--156520092(+) AATAA-/ATATATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for HAVCR2 (156512843 - 156569880 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HAVCR2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HAVCR2
    DNA2.0 Custom Variant and Variant Library Synthesis for HAVCR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606652    OMIM disorders: --

    Selected diseases for HAVCR2 (see all 58):    
    About MalaCards
    dendritic cell thymoma    prostatic adenoma    hepatitis a    histiocytic sarcoma
    thymoma    cerebral malaria    allergic asthma    autoimmune hepatitis
    allergic rhinitis    aplastic anemia    rhinitis    pulmonary tuberculosis
    hepatitis    encephalomyelitis    atopy    malaria
    multiple sclerosis    purpura    tuberculosis    hepatitis c virus

    2 diseases from the University of Copenhagen DISEASES database for HAVCR2:
    Epithelial malignant thymoma     Prostatic adenoma

    HAVCR2 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for HAVCR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 52.4 12 11823861 (3), 19768575 (2), 15272240 (1), 19332093 (1) (see all 7)
    asthma 34.8 11 15867855 (4), 19494522 (3), 18785518 (2), 15603868 (2)
    encephalomyelitis 31.5 2 15153541 (1), 11823861 (1)
    allergic rhinitis 30.9 2 15603868 (2)
    allergy 23.8 3 17517968 (1), 17665973 (1)
    multiple sclerosis 22.7 3 15153541 (1), 17665973 (1), 19768575 (1)
    inflammation 3.35 2 17513715 (2)
    tumors 0 3 17096021 (3)

    Genetic Association Database (GAD): HAVCR2
    Human Genome Epidemiology (HuGE) Navigator: HAVCR2 (23 documents)

    Export disorders for HAVCR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HAVCR2 gene, integrated from 10 sources (see all 138):
    (articles sorted by number of sources associating them with HAVCR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. (PubMed id 11823861)1, 2, 3, 9 Monney L....Kuchroo V.K. (Nature 2002)
    2. Lack of association of TIM3 polymorphisms and allergic phenotypes. (PubMed id 19566956)1, 4, 9 Zhang J....Sandford A.J. (BMC Med. Genet. 2009)
    3. [The relationship between the haplotype of T cells immunoglobulin mucin-3 gene and allergic asthma in the Han population from Hubei province of China]. (PubMed id 18785518)1, 4, 9 Hu L.H....Chen F.H. (Zhonghua Jie He He Hu Xi Za Zhi 2008)
    4. The association of TIM-3 gene polymorphism with atopic disease in Korean population. (PubMed id 15603868)1, 4, 9 Chae S.C....Chung H.T. (Hum. Immunol. 2004)
    5. Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population. (PubMed id 15867855)1, 4, 9 Gao P.S....Huang S.K. (J. Allergy Clin. Immunol. 2005)
    6. Family-based association study of Tim-1 and Tim-3 gene polymorphisms with childhood asthma in Chinese trios. (PubMed id 19494522)1, 4, 9 Wu Q.W....Hu L.H. (Int. Arch. Allergy Immunol. 2009)
    7. The role of T-cell immunoglobulin- and mucin-domain-containing molecule-3 polymorphisms in idiopathic thrombocytopenic purpura. (PubMed id 19332093)1, 4, 9 Du W.T....Yang R.C. (Hum. Immunol. 2009)
    8. Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33. (PubMed id 16159638)1, 4, 9 Graves P.E....Martinez F.D. (J. Allergy Clin. Immunol. 2005)
    9. The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis. (PubMed id 15325803)1, 4, 9 Chae S.C....Chung H.T. (Immunol. Lett. 2004)
    10. Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (PubMed id 18294362)1, 4, 9 Nuchnoi P....Patarapotikul J. (Ann. Hum. Genet. 2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84868 HGNC: 18437 AceView: HAVCR2 Ensembl:ENSG00000135077 euGenes: HUgn84868
    ECgene: HAVCR2 H-InvDB: HAVCR2

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    PharmGKB entry for HAVCR2 Pharmacogenomics, SNPs, Pathways

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