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Aliases for HAVCR2 Gene

Aliases for HAVCR2 Gene

  • Hepatitis A Virus Cellular Receptor 2 2 3
  • TIM3 3 4 6
  • T-Cell Immunoglobulin And Mucin Domain-Containing Protein 3 3 4
  • T-Cell Immunoglobulin Mucin Family Member 3 2 3
  • T-Cell Immunoglobulin Mucin Receptor 3 3 4
  • T-Cell Membrane Protein 3 3 4
  • HAVcr-2 3 4
  • TIMD-3 3 4
  • Tim-3 3 4
  • TIMD3 3 4
  • T Cell Immunoglobulin Mucin 3 3
  • T Cell Immunoglobulin Mucin-3 3
  • Kidney Injury Molecule-3 3
  • KIM-3 3

External Ids for HAVCR2 Gene

Previous GeneCards Identifiers for HAVCR2 Gene

  • GC05M156448
  • GC05M156493
  • GC05M156445
  • GC05M151601
  • GC05M156512

Summaries for HAVCR2 Gene

Entrez Gene Summary for HAVCR2 Gene

  • The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

GeneCards Summary for HAVCR2 Gene

HAVCR2 (Hepatitis A Virus Cellular Receptor 2) is a Protein Coding gene. Diseases associated with HAVCR2 include epithelial malignant thymoma and prostatic adenoma. An important paralog of this gene is TIMD4.

UniProtKB/Swiss-Prot for HAVCR2 Gene

  • Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.

Gene Wiki entry for HAVCR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAVCR2 Gene

Genomics for HAVCR2 Gene

Regulatory Elements for HAVCR2 Gene

Genomic Location for HAVCR2 Gene

157,085,832 bp from pter
157,142,869 bp from pter
57,038 bases
Minus strand

Genomic View for HAVCR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAVCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAVCR2 Gene

Proteins for HAVCR2 Gene

  • Protein details for HAVCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatitis A virus cellular receptor 2
    Protein Accession:
    Secondary Accessions:
    • B2RAY2
    • Q8WW60
    • Q96K94

    Protein attributes for HAVCR2 Gene

    301 amino acids
    Molecular mass:
    33394 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HAVCR2 Gene

    Alternative splice isoforms for HAVCR2 Gene


neXtProt entry for HAVCR2 Gene

Proteomics data for HAVCR2 Gene at MOPED

Post-translational modifications for HAVCR2 Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Thr145 and Asn172
  • Modification sites at PhosphoSitePlus

Other Protein References for HAVCR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for HAVCR2 Gene

Domains for HAVCR2 Gene

Gene Families for HAVCR2 Gene

  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for HAVCR2 Gene

Suggested Antigen Peptide Sequences for HAVCR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8TDQ0
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. TIM family.
genes like me logo Genes that share domains with HAVCR2: view

Function for HAVCR2 Gene

Molecular function for HAVCR2 Gene

UniProtKB/Swiss-Prot Function: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.

Gene Ontology (GO) - Molecular Function for HAVCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with HAVCR2: view
genes like me logo Genes that share phenotypes with HAVCR2: view

Animal Models for HAVCR2 Gene

MGI Knock Outs for HAVCR2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAVCR2

Clone Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HAVCR2 Gene

Localization for HAVCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAVCR2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for HAVCR2 Gene COMPARTMENTS Subcellular localization image for HAVCR2 gene
Compartment Confidence
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for HAVCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HAVCR2: view

Pathways for HAVCR2 Gene

SuperPathways for HAVCR2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • T Helper Cell Differentiation in human,mouse,rat
    • Th1/Th2 Response in human,mouse,rat

Interacting Proteins for HAVCR2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000312002 for HAVCR2 Gene via STRING

Gene Ontology (GO) - Biological Process for HAVCR2 Gene


No data available for Pathways by source for HAVCR2 Gene

Transcripts for HAVCR2 Gene

Unigene Clusters for HAVCR2 Gene

Hepatitis A virus cellular receptor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAVCR2

Clone Products

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAVCR2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: - - -

Relevant External Links for HAVCR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HAVCR2 Gene

mRNA expression in normal human tissues for HAVCR2 Gene

mRNA differential expression in normal tissues according to GTEx for HAVCR2 Gene

This gene is overexpressed in Whole Blood (8.4) and Kidney - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HAVCR2 Gene

SOURCE GeneReport for Unigene cluster for HAVCR2 Gene Hs.710500

mRNA Expression by UniProt/SwissProt for HAVCR2 Gene

Tissue specificity: T-helper type 1 lymphocyte (Th1)-specific
genes like me logo Genes that share expressions with HAVCR2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HAVCR2 Gene

Orthologs for HAVCR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAVCR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HAVCR2 35
  • 98.45 (n)
  • 97.01 (a)
  • 97 (a)
(Bos Taurus)
Mammalia HAVCR2 35
  • 79.26 (n)
  • 68.35 (a)
(Canis familiaris)
Mammalia HAVCR2 35
  • 81.83 (n)
  • 71.48 (a)
  • 65 (a)
(Mus musculus)
Mammalia Havcr2 35
  • 74.64 (n)
  • 66.79 (a)
Havcr2 16
Havcr2 36
  • 63 (a)
(Monodelphis domestica)
Mammalia HAVCR2 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
-- 36
  • 33 (a)
(Rattus norvegicus)
Mammalia Havcr2 35
  • 76.43 (n)
  • 67.86 (a)
(Gallus gallus)
Aves HAVCR1 36
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 2 (a)
(Danio rerio)
Actinopterygii timd4 36
  • 25 (a)
Species with no ortholog for HAVCR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAVCR2 Gene

Gene Tree for HAVCR2 (if available)
Gene Tree for HAVCR2 (if available)

Paralogs for HAVCR2 Gene

Paralogs for HAVCR2 Gene

Selected SIMAP similar genes for HAVCR2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HAVCR2: view

Variants for HAVCR2 Gene

Sequence variations from dbSNP and Humsavar for HAVCR2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs919744 -- 157,104,243(+) GGAAG(C/G)TGATG intron-variant
rs919745 -- 157,104,268(+) TAGAA(A/G)GCATC intron-variant
rs919746 -- 157,104,305(+) AGTTC(C/T)CAAAC intron-variant
rs919747 -- 157,104,319(+) GACTG(A/G)CACCA intron-variant
rs1036199 - 157,104,725(+) TCTGC(A/C)GAGTC reference, missense

Relevant External Links for HAVCR2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HAVCR2 Gene

Disorders for HAVCR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for HAVCR2 Gene including...

Search for HAVCR2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for HAVCR2 Gene

(8) Novoseek inferred disease relationships for HAVCR2 Gene

Disease -log(P) Hits PubMed IDs
autoimmune diseases 52.4 10
asthma 34.8 11
encephalomyelitis 31.5 2
allergic rhinitis 30.9 2
allergy 23.8 2

Relevant External Links for HAVCR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HAVCR2: view

No data available for UniProtKB/Swiss-Prot for HAVCR2 Gene

Publications for HAVCR2 Gene

  1. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. (PMID: 11823861) Monney L. … Kuchroo V.K. (Nature 2002) 2 3 4 23
  2. Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (PMID: 18294362) Nuchnoi P. … Patarapotikul J. (Ann. Hum. Genet. 2008) 3 23 48
  3. The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis. (PMID: 15325803) Chae S.C. … Chung H.T. (Immunol. Lett. 2004) 3 23 48
  4. The association of TIM-3 gene polymorphism with atopic disease in Korean population. (PMID: 15603868) Chae S.C. … Chung H.T. (Hum. Immunol. 2004) 3 23 48
  5. Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population. (PMID: 15867855) Gao P.S. … Huang S.K. (J. Allergy Clin. Immunol. 2005) 3 23 48

Products for HAVCR2 Gene

Sources for HAVCR2 Gene

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