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HAVCR2 Gene

protein-coding GIFtS: 57

GC05M156445

hepatitis A virus cellular receptor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ14428 ^¹, ²
HAVcr-2 ^³
KIM-3 ^²
TIM-3 ^³
TIM3 ^¹, ², ³
TIMD-3 ^³
TIMD3 ^¹, ², ³
Tim-3 ^¹, ²

Descriptions
T cell immunoglobulin mucin 3 ^²
T cell immunoglobulin mucin-3 ^²
T-cell immunoglobulin and mucin domain-containing protein 3 ^³
T-cell membrane protein 3 ^³
hepatitis A virus cellular receptor 2 ^²
kidney injury molecule-3 ^²

External Ids
HGNC: 18437¹
Entrez Gene: 84868²
UniProtKB: Q8TDQ0³
Ensembl: ENSG00000135077⁷

Search outside databases for aliases for HAVCR2 gene

Previous GC identifers: GC05M157063 GC05M156448 GC05M156493

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HAVCR2:

CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the

basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved

in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions,

whereas Th2 cells are involved in the control of extracellular helminthic infections and the

promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions

of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and

enhances the severity of experimental autoimmune encephalomyelitis in mice.[supplied by OMIM]

UniProtKB/Swiss-Prot: TIMD3_HUMAN, Q8TDQ0

Function: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto-

and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell

homing. Receptor for LGALS9

Gene Wiki entry for HAVCR2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HAVCR2 gene

Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q34

HAVCR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M156445: (about GC identifiers)

Start:	156,445,421 bp from pter
End:	156,468,716 bp from pter
Size:	23,296 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_023133.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TIMD3_HUMAN, Q8TDQ0 (See protein sequence)

Recommended Name: Hepatitis A virus cellular receptor 2 precursor

Size: 301 amino acids; 33351 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: Q8WW60 Q96K94

Alternative splicing: 2 isoforms: Q8TDQ0-1 Q8TDQ0-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_116171.3

ENSEMBL proteins:

ENSP00000312002

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for HAVCR2 (TIM-3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TIM 3)
	Human Recombinant Proteins from Abnova (HAVCR2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for HAVCR2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HAVCR2
	R&D Systems Antibodies for HAVCR2 (TIM-3)
	Antibodies from Abcam (TIM 3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HAVCR2)
	Novus Biologicals Antibodies for HAVCR2

Assays for HAVCR2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8TDQ0

ProtoNet protein and cluster: Q8TDQ0

1 Blocks protein family: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: TIMD3_HUMAN, Q8TDQ0

Similarity: Belongs to the immunoglobulin superfamily. TIM family

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAVCR2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HAVCR2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_032782

Applied Biosystems Silencer® siRNAs for HAVCR2

Sigma-Aldrich siRNA and siRNA Panels for HAVCR2

Sigma-Aldrich shRNA for HAVCR2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HAVCR2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_032782
Myc/DDK tagged cDNA clone in CMV expression vector: NM_032782
untagged cDNA clones in CMV expression vector (see all 2): BC020843

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032782

UniProtKB/Swiss-Prot: TIMD3_HUMAN, Q8TDQ0

Function: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto-

and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell

homing. Receptor for LGALS9

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Havcr2):

immune system

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for HAVCR2

3 Interacting proteins for HAVCR2 (ENSP00000312002³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LGALS9	ENSP00000318214³	STRING (score=.879)
IFNG	ENSP00000229135³	STRING (score=.701)
--	ENSP00000368083³	STRING (score=.737)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HAVCR2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAVCR2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HAVCR2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_032782

Sigma-Aldrich siRNA and siRNA Panels for HAVCR2

Sigma-Aldrich shRNA for HAVCR2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032782

REFSEQ mRNAs for HAVCR2 gene:

NM_032782.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032782

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032782
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032782
                                 untagged cDNA clones in CMV expression vector (see all 2): BC020843

Additional cDNA sequence:

AF251707.1 AF450242.1 AF450243.1 AK027334.1 AK130144.1 AK314406.1 AY069944.1 BC020843.1

BC063431.1

6 DOTS entries:

DT.431150 DT.97839520 DT.99928688 DT.120827768 DT.95084108 DT.40291503

24/51 AceView cDNA sequences (see all 51 ):

BQ581620 CD710266 AA664217 CA307836 AF450243 BI906710 AF450242 BX417090

BP340002 BM923617 AI202037 BP344854 AF251707 BG545730 AY069944 AI636449

BC020843 BM505682 BP373569 AL709094 AW025572 AJ705624 AK130144 AU279844

highest scoring ESTs for HAVCR2:

AF251707 AF450242 AF450243 AL709094 AU279844 AW025572 AY069944 BC020843 BC063431 BQ278485

Unigene Cluster for HAVCR2:

Hepatitis A virus cellular receptor 2

Hs.710500 [show with all ESTs]

Unigene Representative Sequence: BC063431

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for HAVCR2

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7
SP1:			-		-
SP2:			-		-						-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for HAVCR2

1 Ensembl transcript including schematic representation:

ENST00000307851

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HAVCR2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HAVCR2

¹ / ² / ³

6 probe-sets matching HAVCR2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
75648_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AW025572	0.80	1.00	0.91	1
235458_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW025572	0.80	1.00	0.91	1
235458_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555629_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555628_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554285_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HAVCR2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATTTGCCTGC

SOURCE GeneReport for Unigene cluster: Hs.710500
UniProtKB/Swiss-Prot: TIMD3_HUMAN, Q8TDQ0
Tissue specificity: T-helper type 1 lymphocyte (Th1)-specific

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HAVCR2 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	HAVCR2¹	--	hepatitis A virus cellular receptor 2	98.66(n) 97.44(a)	462219 XM_518059.2 XP_518059.2
cow (Bos taurus)	HAVCR2¹	--	hepatitis A virus cellular receptor 2	80.34(n) 69.06(a)	768047 NM_001077105.1 NP_001070573.1
mouse (Mus musculus)	Havcr2⁵	11	hepatitis A virus cellular receptor 2	--	BC106852

About this table Species with no ortholog for HAVCR2

ENSEMBL Gene Tree for HAVCR2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HAVCR2 gene

HAVCR1² TIMD4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/224 NCBI SNPs in HAVCR2 are shown (see all 224 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 63)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4704853^1,2	A,C,F,H	156469454(+)	`ACCCCG/AAGAGG`	1	--	ng3¹		6		MN EA EU WA	1662
	rs3087616^1,2	C,F,H,O	156445860(+)	`GCAGGT/CAGTGC`	1	--	ut3¹ ese³		8		MN EU EA WA NA	736
	rs4704846^1,2	A,C,F,H	156445922(+)	`GACCTA/GGTCCA`	1	--	ut3¹		4		EU EA WA	396
	rs10515746^1,2	A,C,F,H	156469146(+)	`ACCATC/AGCAAC`	1	--	ng3¹		16		NS NA EU EA WA	1072
	rs10061463^1,2	C,F,H	156470338(+)	`AAATGC/ACCATA`	1	--	ng3¹		4		EU EA WA	420
	rs1036199^1,2	C,F,H	156464314(+)	`TCTGCA/CGAGTC`	1	R/L	mis¹ ese³		15		EA NA EU WA	2750
	rs9313439^1,2	C,F,H	156445760(+)	`ACTTCC/GTTTTT`	1	--	ut3¹		7		EU EA WA NA	552
--	rs10053538^1,2	A,C	156470088(+)	`actccA/Cgacct`	1	--	ng3¹		0	--	--	--	--
--	rs6555844^1,2	A,C	156444998(+)	`ccctaC/Tttaat`	1	--	ng5¹		0	--	--	--	--
--	rs6555843^1,2	A,C	156444927(+)	`aataaC/Tgccgc`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for HAVCR2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606652

UniProtKB/Swiss-Prot: TIMD3_HUMAN, Q8TDQ0

Genetic variation in HAVCR2 may influence susceptibility to rheumatoid arthritis (RA)

[MIM:180300]. RA is an inflammatory disease, primarily of the joints, with autoimmune features and

a complex genetic component. It is characterized by inflammation of synovial tissues and the

formation of rheumatoid pannus, which is capable of eroding adjacent cartilage and bone, causing

subsequent joint destruction

8 Novoseek disease relationships for HAVCR2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune diseases	46.88	8	11823861 (3), 15272240 (1), 15603868 (1), 17665973 (1)
encephalomyelitis	36.80	2	15153541 (1), 11823861 (1)
allergic rhinitis	36.68	2	15603868 (2)
asthma	30.42	8	15867855 (4), 18785518 (2), 15603868 (2)
allergy	17.13	3	17517968 (1), 17665973 (1)
multiple sclerosis	16.14	2	15153541 (1), 17665973 (1)
inflammation	0.00	2	17513715 (2)
tumors	0.00	3	17096021 (3)

About this table

Genetic Association Database: HAVCR2
Human Genome Epidemiology Navigator: HAVCR2 (12 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/45 PubMed articles for HAVCR2 gene (see all 45 ):

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. (PubMed id 11823861)^{1, 2, 3, 4} Monney L....Kuchroo V.K. (2002)
The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis. (PubMed id 15325803)^{1, 3, 4, 6} Chae S.-C.... Chung H.-T. (2004)
The association of TIM-3 gene polymorphism with atopic disease in Korean population. (PubMed id 15603868)^{1, 3, 6} Chae S.C....Chung H.T. (2004)
Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population. (PubMed id 15867855)^{1, 3, 6} Gao P.S....Huang S.K. (2005)
Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33. (PubMed id 16159638)^{1, 3, 6} Graves P.E....Martinez F.D. (2005)
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. (PubMed id 16286920)^{3, 4} Zhu C.... Kuchroo V.K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. (PubMed id 14556005)^{3, 4} Sanchez-Fueyo A.... Strom T.B. (2003)
Increased T cell immunoglobulin mucin-3 and its ligand in acquired aplastic anemia. (PubMed id 18485114)^{1, 3} Zhang J....Qu X. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 84868	HGNC: 18437	AceView: HAVCR2	Ensembl:ENSG00000135077	euGenes: HUgn84868
ECgene: HAVCR2	H-InvDB: HAVCR2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for HAVCR2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HAVCR2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HAVCR2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HAVCR2		Antibodies for HAVCR2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HAVCR2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HAVCR2)
	Antibodies (HAVCR2)
	Chimera RNAi (HAVCR2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (TIM 3)
	Antibodies (TIM 3)

Search OriGene for HAVCR2

Search Tocris compounds for HAVCR2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HAVCR2

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HAVCR2 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for HAVCR2

Summaries
for HAVCR2

Genomic Location
for HAVCR2

Proteins
for HAVCR2

Protein Domains/
Families
for HAVCR2

Gene Function
for HAVCR2

Pathways & Interactions
for HAVCR2

Drugs & Compounds
for HAVCR2

Transcripts
for HAVCR2

Expression
for HAVCR2

Orthologs
for HAVCR2

Paralogs
for HAVCR2

SNPs/Variants
for HAVCR2

Disorders & Mutations
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Medical News
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Publications
for HAVCR2

Search for HAVCR2

Genome Databases showing HAVCR2

Other Databases showing HAVCR2

Specialized Databases showing HAVCR2

Licensable Technologies
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Services
for HAVCR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HAVCR2 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor HAVCR2

Summariesfor HAVCR2

Genomic Locationfor HAVCR2

Proteinsfor HAVCR2

Protein Domains/Familiesfor HAVCR2

Gene Functionfor HAVCR2

Pathways & Interactionsfor HAVCR2

Drugs & Compoundsfor HAVCR2

Transcriptsfor HAVCR2

Expression for HAVCR2

Orthologsfor HAVCR2

Paralogsfor HAVCR2

SNPs/Variantsfor HAVCR2

Disorders & Mutationsfor HAVCR2

Medical Newsfor HAVCR2

Publicationsfor HAVCR2

Search for HAVCR2

Genome Databases showing HAVCR2

Other Databases showing HAVCR2

Specialized Databases showing HAVCR2

Licensable Technologiesfor HAVCR2

Servicesfor HAVCR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HAVCR2

Summaries
for HAVCR2

Genomic Location
for HAVCR2

Proteins
for HAVCR2

Protein Domains/
Families
for HAVCR2

Gene Function
for HAVCR2

Pathways & Interactions
for HAVCR2

Drugs & Compounds
for HAVCR2

Transcripts
for HAVCR2

Expression
for HAVCR2

Orthologs
for HAVCR2

Paralogs
for HAVCR2

SNPs/Variants
for HAVCR2

Disorders & Mutations
for HAVCR2

Medical News
for HAVCR2

Publications
for HAVCR2

Licensable Technologies
for HAVCR2

Services
for HAVCR2