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HAVCR1 Gene

protein-coding   GIFtS: 60
GCID: GC05M156456

Hepatitis A Virus Cellular Receptor 1

  See HAVCR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hepatitis A Virus Cellular Receptor 11 2     TIMD12 3
T-Cell Immunoglobulin Mucin Family Member 11 2     T-Cell Immunoglobulin Mucin Receptor 12 3
Kidney Injury Molecule 12 3     T-Cell Membrane Protein 12 3
KIM-12 3     HAVCR2 5
KIM12 3     HAVCR-12
TIM2 3     T Cell Immunoglobin Domain And Mucin Domain Protein 12
TIM-12 3     HAVcr-13
TIM12 3     T-Cell Immunoglobulin And Mucin Domain-Containing Protein 13
TIMD-12 3     

External Ids:    HGNC: 178661   Entrez Gene: 267622   Ensembl: ENSG000001132497   OMIM: 6065185   UniProtKB: Q96D423   

Export aliases for HAVCR1 gene to outside databases

Previous GC identifers: GC05M157007 GC05M156391 GC05M156437 GC05M156389 GC05M151544


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAVCR1 Gene:
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The
encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome
represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV
seropositive individuals. Three transcript variants encoding the same protein have been found for this gene.
(provided by RefSeq, Mar 2010)

GeneCards Summary for HAVCR1 Gene:
HAVCR1 (hepatitis A virus cellular receptor 1) is a protein-coding gene. Diseases associated with HAVCR1 include hepatitis, and multicentric reticulohistiocytosis. GO annotations related to this gene include virus receptor activity. An important paralog of this gene is HAVCR2.

UniProtKB/Swiss-Prot: HAVR1_HUMAN, Q96D42
Function: May play a role in T-helper cell development and the regulation of asthma and allergic diseases.
Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a
cell-surface receptor for the virus. May play a role in kidney injury and repair

Gene Wiki entry for HAVCR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAVCR1 gene promoter:
         c-Fos   STAT1   AP-1   Bach2   ATF-2   Sox9   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAVCR1 promoter sequence
   Search Chromatin IP Primers for HAVCR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAVCR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.2   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.2

HAVCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAVCR1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M156456:  view genomic region     (about GC identifiers)

Start:
156,456,424 bp from pter      End:
156,486,130 bp from pter
Size:
29,707 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HAVR1_HUMAN, Q96D42 (See protein sequence)
Recommended Name: Hepatitis A virus cellular receptor 1 precursor  
Size: 359 amino acids; 38720 Da
Miscellaneous: The extracellular part of the protein can be cleaved and detected in urine and is in correlation
with the expression in the kidney
Secondary accessions: O43656

Explore the universe of human proteins at neXtProt for HAVCR1: NX_Q96D42

Explore proteomics data for HAVCR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn65, Asn258, Asn272, Asn286
  • Modification sites at PhosphoSitePlus

  • See HAVCR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001092884.1  NP_001166864.1  NP_036338.2  

    ENSEMBL proteins: 
     ENSP00000428524   ENSP00000427898   ENSP00000344844   ENSP00000428422   ENSP00000403333  
     ENSP00000440258  

    HAVCR1 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for HAVCR1
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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for HAVCR1 (12 products) 

     
    antibodies-online peptides for HAVCR1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q96D42

    ProtoNet protein and cluster: Q96D42

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: HAVR1_HUMAN, Q96D42
    Similarity: Belongs to the immunoglobulin superfamily. TIM family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with HAVCR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HAVR1_HUMAN, Q96D42
    Function: May play a role in T-helper cell development and the regulation of asthma and allergic diseases.
    Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a
    cell-surface receptor for the virus. May play a role in kidney injury and repair
    Induction: Up-regulated in the kidney in renal diseases (at protein level)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with HAVCR1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Havcr1):
     hematopoietic system  immune system  respiratory system 

    Find genes that share phenotypes with HAVCR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Havcr1tm1Shw for HAVCR1

       genOway: Develop your customized and physiologically relevant rodent model for HAVCR1

    miRNA
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    miRTarBase miRNAs that target HAVCR1:
    hsa-mir-148b-3p (MIRT019312), hsa-mir-335-5p (MIRT018340)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HAVR1_HUMAN, Q96D42: Membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytoskeleton2
    extracellular2
    endoplasmic reticulum1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with HAVCR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including HAVCR1: 
              Nephrotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HAVCR1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for HAVCR1 (Q96D422, 3 ENSP000003448444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2872068 I2D: score=3 STRING: ENSP00000357292
    SEMA4AQ9H3S13, ENSP000003471174I2D: score=1 STRING: ENSP00000347117
    TIMD4ENSP000002745324STRING: ENSP00000274532
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    Find genes that share ontologies with HAVCR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HAVCR1 (HAVR1)

    1 Novoseek inferred chemical compound relationship for HAVCR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 4 16284246 (1)



    Find genes that share compounds with HAVCR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HAVCR1 gene (3 alternative transcripts): 
    NM_001099414.1  NM_001173393.1  NM_012206.2  

    Unigene Cluster for HAVCR1:

    Hepatitis A virus cellular receptor 1
    Hs.129711  [show with all ESTs]
    Unigene Representative Sequence: NM_012206
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522693(uc011ddl.1 uc011ddm.2) ENST00000523175(uc021ygj.1 uc021ygk.1)
    ENST00000339252(uc003lwi.2) ENST00000517644 ENST00000518745 ENST00000425854
    ENST00000544197(uc010jij.1)
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    Additional mRNA sequence: 

    AF043724.1 AK298259.1 BC013325.1 CR457114.1 JX049978.1 

    5 DOTS entries:

    DT.91905981  DT.40127952  DT.95266388  DT.91653394  DT.40262844 

    23 AceView cDNA sequences:

    AA912911 CR457114 AI218437 AW849281 BX283851 AW849356 AW849406 BU148837 
    BG168159 BC013325 BV188647 BG326440 AW439507 BE739579 AW849403 BE273684 
    AF043724 BG752287 NM_012206 BX957193 BE739332 AW604191 BE811431 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HAVCR1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                                                          
    SP2:              -     -                                                                     
    SP3:        -     -                                                                           
    SP4:                                                                                -         


    ECgene alternative splicing isoforms for HAVCR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HAVCR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATCACCG
    HAVCR1 Expression
    About this image


    HAVCR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             DKK1-induced cells
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    HAVCR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HAVCR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129711

    UniProtKB/Swiss-Prot: HAVR1_HUMAN, Q96D42
    Tissue specificity: Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+
    T-cells during the development of helper T-cells responses

        Pathway & Disease-focused RT2 Profiler PCR Array including HAVCR1: 
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HAVCR1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Havcr15 hepatitis A virus cellular receptor 1   --   11 (28.08 cM) 46735080 
    chicken
    (Gallus gallus)
    Aves HAVCR11 hepatitis A virus cellular receptor 1 54.72(n)
    49.06(a)
      416249  NM_001030617.1  NP_001025788.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    2(a)
    many ↔ many
    GL343205.1(2551432-2551587)
    zebrafish
    (Danio rerio)
    Actinopterygii timd46
    T-cell immunoglobulin and mucin domain containing ...
    19(a)
    1 → many
    21(28485046-28494504) ENSDARG00000077257


    ENSEMBL Gene Tree for HAVCR1 (if available)
    TreeFam Gene Tree for HAVCR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HAVCR1 gene
    HAVCR22  TIMD42  
    1 SIMAP similar gene for HAVCR1 using alignment to 7 protein entries:     HAVR1_HUMAN (see all proteins):
    HAVCR2

    Find genes that share paralogs with HAVCR1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for HAVCR1
    PGOHUM00000256710 PGOHUM00000234272 PGOHUM00000257093


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    HAVR1_HUMAN, Q96D42: Infection by hepatitis A virus (HAV) protects individuals from atopy if they carry insertion of the
    variants Met-Thr-Thr-Val-Pro-157 and Met-Thr-Thr-Thr-Val-Pro-157. Modernisation has led to a reduction in HAV
    seroprevalence and thus, may be, to an increase of expression of atopy, such as asthma, allergic rhinitis and
    atopic dermatitis. Allelic variation does not affect HAV-infection rates in Caucasians, Asians and African
    Americans


    Selected SNPs for HAVCR1 (see all 969)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1414722491,2
    Cuntested1156706978(+) GATGGA/CCCTGC 6 G syn11Minor allele frequency- C:0.00EU 739
    rs712850411,2
    C--151546487(-) AAGCC-/A/AA  
            
    AAAAA
    3 -- int11NA 2
    rs32151201,2
    C--151558610(-) CTCCT-/TCTGAATA 3 -- int10--------
    rs358316131,2
    C--151558612(+) TTCAG-/AAGGAGTA 3 -- int10--------
    rs754239151,2
    C--151558612(+) TTCAGA/GAGGAG 3 -- int10--------
    rs1917464781,2
    --151559844(+) ACGAAA/GGAAGG 3 -- int10--------
    rs3770685181,2
    C--151559871(+) GAAGG-/AGGGAAG 3 -- int10--------
    rs583011761,2
    --151559876(+) AGGAAA/GGAAGG 3 -- int10--------
    rs2007556961,2
    C--151559938(+) GGAAGA/GAAGGA 3 -- int10--------
    rs596783701,2
    C--151559942(+) GGAAGG/AAAGGA 3 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for HAVCR1 (156456424 - 156486130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HAVCR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730954CNV Deletion23290073

    Human Gene Mutation Database (HGMD): HAVCR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HAVCR1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606518   
    OMIM disorders: 147050  
    11 diseases for HAVCR1:    
    About MalaCards
    hepatitis    multicentric reticulohistiocytosis    hepatitis a    atopy
    cutaneous fibrous histiocytoma    allergy and asthma susceptibility    fibrous histiocytoma    allergic rhinitis
    cerebral malaria    asthma    malaria

    4 diseases from the University of Copenhagen DISEASES database for HAVCR1:
    Cutaneous fibrous histiocytoma     Kidney disease     Histiocytosis     Multicentric reticulohistiocytosis

    Find genes that share disorders with HAVCR1           About GenesLikeMe

    9 Novoseek inferred disease relationships for HAVCR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis 59.5 23 17229699 (2), 9658108 (2), 19860892 (2), 12618867 (1) (see all 11)
    asthma allergic 51.4 6 15300647 (3), 19476019 (1), 16284246 (1)
    atopy 47.6 6 14637143 (1), 16159638 (1), 16481347 (1), 17229699 (1)
    asthma 46.9 26 17570927 (4), 17117951 (4), 19494522 (3), 15867855 (3) (see all 9)
    autoimmunity 46.1 3 17069754 (1), 16938542 (1), 20083673 (1)
    allergic rhinitis 45.2 6 20232767 (4), 17460580 (1), 19159567 (1)
    autoimmune diseases 24.1 2 15565336 (1), 17729033 (1)
    dermatitis atopic 19.9 3 16940744 (2), 14637143 (1)
    rheumatoid arthritis 0 4 15565336 (2), 14985107 (2)

    Genetic Association Database (GAD): HAVCR1
    Human Genome Epidemiology (HuGE) Navigator: HAVCR1 (24 documents)

    Export disorders for HAVCR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HAVCR1 gene, integrated from 10 sources (see all 130):
    (articles sorted by number of sources associating them with HAVCR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. (PubMed id 9658108)1, 2, 3, 9 Feigelstock D.... Kaplan G.G. (J. Virol. 1998)
    2. Association between TIM-1 gene polymorphisms and allergic rhinitis in a Han Chinese population. (PubMed id 20232767)1, 4, 9 Mou Z....Li H. (amp 2010)
    3. Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (PubMed id 18294362)1, 4, 9 Nuchnoi P....Patarapotikul J. (Ann. Hum. Genet. 2008)
    4. A functional polymorphism in the TIM-1 gene is associated with asthma in a Chinese Han population. (PubMed id 17570927)1, 4, 9 Liu Q....Gong Y. (Int. Arch. Allergy Immunol. 2007)
    5. Absence of association between two insertion/deletion coding genetic polymorphisms of TIM-1 gene and asthma in Chinese Han population. (PubMed id 17117951)1, 4, 9 Li J.S....Gong Y.Q. (Int. J. Immunogenet. 2006)
    6. Family-based association study of Tim-1 and Tim-3 gene polymorphisms with childhood asthma in Chinese trios. (PubMed id 19494522)1, 4, 9 Wu Q.W....Hu L.H. (Int. Arch. Allergy Immunol. 2009)
    7. Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. (PubMed id 17229699)1, 2, 9 Tami C.... Kaplan G.G. (J. Virol. 2007)
    8. Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population. (PubMed id 15867855)1, 4, 9 Gao P.S....Huang S.K. (J. Allergy Clin. Immunol. 2005)
    9. Fine mapping of T-cell immunoglobulin mucin domain gene 1 failed to detect a significant association with multiple sclerosis. (PubMed id 20070602)1, 4, 9 Grabmer C....Gassner C. (Tissue Antigens 2010)
    10. Association analysis of TIM-1 -232G &gt; A and 5383_5397 insertion/deletion polymorphisms with childhood asthma and total serum immunoglobulin E levels in middle China. (PubMed id 19476019)1, 4, 9 Wu Q....Kong L. (amp 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26762 HGNC: 17866 AceView: HAVCR1 Ensembl:ENSG00000113249 euGenes: HUgn26762
    ECgene: HAVCR1 H-InvDB: HAVCR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HAVCR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HAVCR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HAVCR1 gene:
    Search GeneIP for patents involving HAVCR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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