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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HAVCR1 Gene

protein-coding   GIFtS: 59
GCID: GC05M156456

hepatitis A virus cellular receptor 1
 Explore 35 diseases affiliated with
HAVCR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HAVCR1    

Aliases
for HAVCR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Hepatitis A Virus Cellular Receptor 11 2     KIM12 3
TIM-11 2 3     TIM2 3
TIM11 2 3     TIMD-12 3
TIMD11 2 3     T-Cell Membrane Protein 12 3
HAVCR1 2 5     T Cell Immunoglobin Domain And Mucin Domain Protein 12
HAVCR-11 2     HAVcr-13
Kidney Injury Molecule 12 3     T-Cell Immunoglobulin And Mucin Domain-Containing Protein 13
KIM-12 3     

External Ids:    HGNC: 178661   Entrez Gene: 267622   Ensembl: ENSG000001132497   OMIM: 6065185   UniProtKB: Q96D423   

Export aliases for HAVCR1 gene to outside databases

Previous GC identifers: GC05M157007 GC05M156391 GC05M156437 GC05M156389 GC05M151544


Summaries
for HAVCR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HAVCR1:
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded
protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele
that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: HAVR1_HUMAN, Q96D42
Function: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for
TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for
the virus. May play a role in kidney injury and repair

Gene Wiki entry for HAVCR1


Genomic Views
for HAVCR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HAVCR1 gene promoter:
         c-Fos   STAT1   AP-1   Bach2   ATF-2   Sox9   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HAVCR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HAVCR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAVCR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.2   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.2

HAVCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAVCR1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M156456:  view genomic region     (about GC identifiers)

Start:
 156,456,424 bp from pter      End:
 156,486,130 bp from pter
Size:
 29,707 bases      Orientation:
 minus strand

Proteins
for HAVCR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HAVR1_HUMAN, Q96D42 (See protein sequence)
Recommended Name: Hepatitis A virus cellular receptor 1 precursor  
Size: 359 amino acids; 38720 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
Miscellaneous: The extracellular part of the protein can be cleaved and detected in urine and is in correlation with
the expression in the kidney
Secondary accessions: O43656

Explore the universe of human proteins at neXtProt for HAVCR1: NX_Q96D42

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96D42

    • HAVCR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001092884.1  NP_001166864.1  NP_036338.2  

    ENSEMBL proteins: 
     ENSP00000428524   ENSP00000427898   ENSP00000344844   ENSP00000428422   ENSP00000403333  
     ENSP00000440258  

    Human Recombinant Protein Products: 
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    Novus Biologicals HAVCR1 Proteins
    Novus Biologicals HAVCR1 Lysate
    Sino Biological Recombinant Protein for HAVCR1
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    Uscn Proteins for HAVCR1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    HAVCR1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for HAVCR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HAVCR1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q96D42

    ProtoNet protein and cluster: Q96D42

    1 Blocks protein family: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: HAVR1_HUMAN, Q96D42
    Similarity: Belongs to the immunoglobulin superfamily. TIM family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for HAVCR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HAVR1_HUMAN, Q96D42
    Function: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for
    TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for
    the virus. May play a role in kidney injury and repair
    Induction: Up-regulated in the kidney in renal diseases (at protein level)

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----


    HAVCR1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Havcr1tm1Shw for HAVCR1
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Havcr1):
     cellular  hematopoietic system  immune system  respiratory system 

    HAVCR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HAVCR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HAVCR1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for HAVCR1 (Q96D422, 3 ENSP000003448444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2872068 I2D: score=3 STRING: ENSP00000357292
    SEMA4AQ9H3S13, ENSP000003471174I2D: score=1 STRING: ENSP00000347117
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----


    HAVCR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HAVCR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HAVCR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HAVCR1
    1 Novoseek chemical compound relationship for HAVCR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 4 16284246 (1)

    Search CenterWatch for drugs/clinical trials and news about HAVCR1 / HAVR1 

    Transcripts
    for HAVCR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HAVCR1 gene (3 alternative transcripts): 
    NM_001099414.1  NM_001173393.1  NM_012206.2  

    Unigene Cluster for HAVCR1:

    Hepatitis A virus cellular receptor 1
    Hs.129711  [show with all ESTs]
    Unigene Representative Sequence: NM_012206
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522693(uc011ddl.1 uc011ddm.2) ENST00000523175(uc021ygj.1 uc021ygk.1)
    ENST00000339252(uc003lwi.2) ENST00000517644 ENST00000518745 ENST00000425854
    ENST00000544197(uc010jij.1)

    miRNA
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    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAVCR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAVCR1

    Additional cDNA sequence: 

    AF043724.1 AK298259.1 BC013325.1 CR457114.1 JX049978.1 

    5 DOTS entries:

    DT.91905981  DT.40127952  DT.95266388  DT.91653394  DT.40262844 

    23 AceView cDNA sequences:

    AW849281 CR457114 AA912911 BX283851 AW849356 AI218437 BV188647 AW849403 
    AW439507 BE739579 BU148837 BG168159 BC013325 AW849406 BG326440 BE273684 
    AF043724 BG752287 NM_012206 BX957193 BE739332 AW604191 BE811431 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HAVCR1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                                                          
    SP2:              -     -                                                                     
    SP3:        -     -                                                                           
    SP4:                                                                                -         


    ECgene alternative splicing isoforms for HAVCR1

    Expression
    for HAVCR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HAVCR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAATCACCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HAVCR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)
    DKK1-induced cells (Derivation of cardio...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HAVCR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HAVCR1

    SOURCE GeneReport for Unigene cluster: Hs.129711

    UniProtKB/Swiss-Prot: HAVR1_HUMAN, Q96D42
    Tissue specificity: Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells
    during the development of helper T-cells responses

        SABiosciences Expression via Pathway-Focused PCR Array including HAVCR1: 
              Nephrotoxicity in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for HAVCR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HAVCR1 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves Q5ZKI8_CHICK6
    		 hepatitis A virus cellular receptor 1
    		 42(a)
    		 1 → many
    		 13(11525677-11573991)
    zebrafish
    (Danio rerio)    		 Actinopterygii timd46
    		 T-cell immunoglobulin and mucin domain containing ...
    		 23(a)
    		 1 → many
    		 21(28485046-28494504)


    ENSEMBL Gene Tree for HAVCR1 (if available)
    TreeFam Gene Tree for HAVCR1 (if available) 

    Paralogs
    for HAVCR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HAVCR1 gene
    HAVCR22  TIMD42  
    1 SIMAP similar gene for HAVCR1 using alignment to 7 protein entries:     HAVR1_HUMAN (see all proteins):
    HAVCR2

    HAVCR1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for HAVCR1
    PGOHUM00000256710 PGOHUM00000234272 PGOHUM00000257093


    Genomic Variants
    for HAVCR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: HAVR1_HUMAN, Q96D42
    Polymorphism: Infection by hepatitis A virus (HAV) protects individuals from atopy if they carry insertion of the
    variants Met-Thr-Thr-Val-Pro-157 and Met-Thr-Thr-Thr-Val-Pro-157. Modernisation has led to a reduction in HAV
    seroprevalence and thus, may be, to an increase of expression of atopy, such as asthma, allergic rhinitis and atopic
    dermatitis. Allelic variation does not affect HAV-infection rates in Caucasians, Asians and African Americans


    10/794 NCBI SNPs in HAVCR1 are shown (see all 794)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1414722491,2
    		Cother189353761(+) GATGGA/CCCTGC 6 G syn11Minor allele frequency- C:0.00EU 739
    rs346940181,2
    		C--151544566(+) ACTGGG/TAAAAC 3 -- ds50010--------
    rs778176431,2
    		C,F,--151544668(+) TTCCCC/AACGGA 3 -- ds50011Minor allele frequency- A:0.06WA 118
    rs738139401,2
    		C,F,--151545806(+) TACTGT/ATTCAC 3 -- int13Minor allele frequency- A:0.10WA CSA 122
    rs68689901,2
    		C,F,--151546782(+) GAAAGT/ACTGTG 3 -- int11Minor allele frequency- A:0.06WA 118
    rs615961061,2
    		C,F,--151547324(+) TAAAGG/ACAAAT 3 -- int13Minor allele frequency- A:0.10WA CSA 122
    rs728051481,2
    		C,--151547402(+) AATGAC/TGGAAG 3 -- int10--------
    rs1130627741,2
    		--151547938(+) GCCGAG/AAAGGT 3 -- int12Minor allele frequency- A:0.06CSA WA 120
    rs610473471,2
    		C,--151548040(+) TCATT-/CAATGT 3 -- int10--------
    rs77324781,2
    		C,F,H,--151548147(+) CCAGGG/AAAATA 3 -- int17Minor allele frequency- A:0.03NS EA WA CSA 540

    HapMap Linkage Disequilibrium report for HAVCR1 (156456424 - 156486130 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HAVCR1: --
    Human Gene Mutation Database (HGMD): HAVCR1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HAVCR1
    DNA2.0 Custom Variant and Variant Library Synthesis for HAVCR1

    Disorders / Diseases
    for HAVCR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HAVCR1 for disorders           About GeneDecksing

    OMIM gene information: 606518   
    OMIM disorders: 147050  
    20/35 diseases for HAVCR1 (see all 35):    About MalaCards
    hepatitis a    hepatitis    atopy    asthma
    multicentric reticulohistiocytosis    fibrous histiocytoma    cutaneous fibrous histiocytoma    clear cell renal cell carcinoma
    allergic rhinitis    histiocytoma    allergy and asthma susceptibility    systemic lupus erythematosus
    renal cell carcinoma    atopy, resistance to    lupus erythematosus    atopic dermatitis
    rhinitis    rheumatoid arthritis    allergic asthma    dermatitis

    4 diseases from the University of Copenhagen DISEASES database for HAVCR1:
    Cutaneous fibrous histiocytoma     Kidney disease     Histiocytosis     Multicentric reticulohistiocytosis

    9 Novoseek disease relationships for HAVCR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis 59.5 23 17229699 (2), 9658108 (2), 19860892 (2), 12618867 (1) (see all 11)
    asthma allergic 51.4 6 15300647 (3), 19476019 (1), 16284246 (1)
    atopy 47.6 6 14637143 (1), 16159638 (1), 16481347 (1), 17229699 (1)
    asthma 46.9 26 17570927 (4), 17117951 (4), 19494522 (3), 15867855 (3) (see all 9)
    autoimmunity 46.1 3 17069754 (1), 16938542 (1), 20083673 (1)
    allergic rhinitis 45.2 6 20232767 (4), 17460580 (1), 19159567 (1)
    autoimmune diseases 24.1 2 15565336 (1), 17729033 (1)
    dermatitis atopic 19.9 3 16940744 (2), 14637143 (1)
    rheumatoid arthritis 0 4 15565336 (2), 14985107 (2)

    Genetic Association Database (GAD): HAVCR1
    Human Genome Epidemiology (HuGE) Navigator: HAVCR1 (24 documents)

    Export disorders for HAVCR1 gene to outside databases

    Publications
    for HAVCR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HAVCR1 gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with HAVCR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. (PubMed id 9658108)1, 2, 3, 9 Feigelstock D.... Kaplan G.G. (1998)
    2. Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. (PubMed id 17229699)1, 2, 9 Tami C.... Kaplan G.G. (2007)
    3. Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population. (PubMed id 15867855)1, 4, 9 Gao P.S....Huang S.K. (2005)
    4. Insertion/deletion coding polymorphisms in hHAVcr-1 are not associated with atopic asthma in the Japanese population. (PubMed id 12618867)1, 4, 9 Noguchi E....Arinami T. (2003)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Hepatitis A virus link to atopic disease. (PubMed id 14534576)1, 2 McIntire J.J.... Umetsu D.T. (2003)
    7. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. (PubMed id 11725301)1, 3 McIntire J.J....DeKruyff R.H. (2001)
    8. Association between TIM-1 gene polymorphisms and alle rgic rhinitis in a Han Chinese population. (PubMed id 20232767)1, 9 Mou Z....Li H. (2010)
    9. Altered expression of T cell immunoglobulin-mucin (TI M) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis. (PubMed id 19480659)1, 9 Idali F....Grunewald J. (2009)
    10. Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (PubMed id 18294362)1, 9 Nuchnoi P....Patarapotikul J. (2008)

    External Searches for HAVCR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing HAVCR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26762 HGNC: 17866 AceView: HAVCR1 Ensembl:ENSG00000113249 euGenes: HUgn26762
    ECgene: HAVCR1 H-InvDB: HAVCR1

    Other Databases showing HAVCR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HAVCR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HAVCR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HAVCR1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HAVCR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HAVCR1 gene:
    Search GeneIP for patents involving HAVCR1

    GeneCards and IP:
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