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HAUS8 Gene

protein-coding   GIFtS: 46
GCID: GC19M017160

HAUS Augmin-Like Complex, Subunit 8

(Previous names: HEC1/NDC80 interacting, centrosome associated 1)
(Previous symbol: HICE1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HAUS Augmin-Like Complex, Subunit 81 2     DGT42 5
HICE11 2 3 5     NY-SAR-482
HEC1/NDC80 Interacting, Centrosome Associated 11 2     HAUS Augmin-Like Complex Subunit 82
Sarcoma Antigen NY-SAR-482 3     Hec1-Interacting And Centrosome-Associated 12
HEC1/NDC80-Interacting Centrosome-Associated Protein 12 3     

External Ids:    HGNC: 305321   Entrez Gene: 933232   Ensembl: ENSG000001313517   OMIM: 6134345   UniProtKB: Q9BT253   

Export aliases for HAUS8 gene to outside databases

Previous GC identifers: GC19M017024 GC19M017025 GC19M016729


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAUS8 Gene:
HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first
identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin
complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is
vital to mitotic spindle assembly (Goshima et al., 2008 (PubMed 18443220); Uehara et al., 2009 (PubMed
19369198)).(supplied by OMIM, Jun 2010)

GeneCards Summary for HAUS8 Gene:
HAUS8 (HAUS augmin-like complex, subunit 8) is a protein-coding gene.

UniProtKB/Swiss-Prot: HAUS8_HUMAN, Q9BT25
Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of
cytokinesis as part of the HAUS augmin-like complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAUS8 gene promoter:
         Elk-1   GATA-3   RREB-1   GCNF   MIF-1   GATA-1   AREB6   GCNF-1   Cart-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAUS8 promoter sequence
   Search Chromatin IP Primers for HAUS8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAUS8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

HAUS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAUS8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M017160:  view genomic region     (about GC identifiers)

Start:
17,160,539 bp from pter      End:
17,186,435 bp from pter
Size:
25,897 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HAUS8_HUMAN, Q9BT25 (See protein sequence)
Recommended Name: HAUS augmin-like complex subunit 8  
Size: 410 amino acids; 44857 Da
Subunit: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and
this interaction is required for spindle assembly. Associates with microtubules. The interaction with
microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this
interaction is direct or indirect
Sequence caution: Sequence=AAH10176.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAO65172.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO65172.1;
Type=Frameshift; Positions=222, 241, 269, 278, 279;
Secondary accessions: B4DJA7 C9JBZ4 Q49AC4 Q86WF0 Q96FX3
Alternative splicing: 3 isoforms:  Q9BT25-1   Q9BT25-2   Q9BT25-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for HAUS8: NX_Q9BT25

Explore proteomics data for HAUS8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HAUS8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001011699.1  NP_219485.1  

    ENSEMBL proteins: 
     ENSP00000253669   ENSP00000395298   ENSP00000470829   ENSP00000471868   ENSP00000473111  

    HAUS8 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HAUS8
    OriGene Custom MassSpec
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    Novus Biologicals HAUS8 Protein
    Novus Biologicals HAUS8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HAUS8

     
    Search eBioscience for Proteins for HAUS8 

     
    antibodies-online proteins for HAUS8 (5 products) 

     
    antibodies-online peptides for HAUS8

    HAUS8 Antibody Products:

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    ThermoFisher Antibody for HAUS8
    LSBio Antibodies in human, mouse, rat for HAUS8
    antibodies-online antibodies for HAUS8 (24 products) 

    HAUS8 Assay Products:

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    Cloud-Clone Corp. ELISAs for HAUS8
    Cloud-Clone Corp. CLIAs for HAUS8
    Search eBioscience for ELISAs for HAUS8 
    antibodies-online kits for HAUS8 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HAUS: HAUS augmin-like complex subunits

    ProtoNet protein and cluster: Q9BT25

    UniProtKB/Swiss-Prot: HAUS8_HUMAN, Q9BT25
    Similarity: Belongs to the HAUS8 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HAUS8_HUMAN, Q9BT25
    Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of
    cytokinesis as part of the HAUS augmin-like complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with HAUS8           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAUS8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HAUS8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAUS8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAUS8

    miRNA
    Products:
        
    miRTarBase miRNAs that target HAUS8:
    hsa-mir-193b-3p (MIRT016543), hsa-mir-93-5p (MIRT027964), hsa-mir-222-3p (MIRT046686), hsa-mir-26b-5p (MIRT028948)

    Block miRNA regulation of human, mouse, rat HAUS8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HAUS8 (see all 20):
    hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-93 hsa-miR-520d-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HAUS8

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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): HAUS8 (NM_033417)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAUS8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAUS8

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HAUS8_HUMAN, Q9BT25: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
    cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, primarily cytoplasmic and
    associates with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During
    anaphase and telophase, additionally associates with the spindle midzone and midbody, respectively
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--
    GO:0005874microtubule IEA--
    GO:0070652HAUS complex IDA19369198

    Find genes that share ontologies with HAUS8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HAUS8
    Interactions:

        Search GeneGlobe Interaction Network for HAUS8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for HAUS8 (Q9BT253 ENSP000002536694) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAUS1Q96CS23, ENSP000002820584I2D: score=1 STRING: ENSP00000282058
    HAUS2Q9NVX03, ENSP000002603724I2D: score=1 STRING: ENSP00000260372
    HAUS6Q7Z4H73, ENSP000003698714I2D: score=1 STRING: ENSP00000369871
    HAUS4Q9H6D73, ENSP000002064744I2D: score=1 STRING: ENSP00000206474
    HAUS3ENSP000002437064STRING: ENSP00000243706
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0051225spindle assembly IMP19369198
    GO:0051297centrosome organization IMP19427217

    Find genes that share ontologies with HAUS8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HAUS8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HAUS8 gene (2 alternative transcripts): 
    NM_001011699.1  NM_033417.1  

    Unigene Cluster for HAUS8:

    HAUS augmin-like complex, subunit 8
    Hs.404088  [show with all ESTs]
    Unigene Representative Sequence: AK130803
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253669(uc002nfe.3) ENST00000597917 ENST00000448593(uc002nff.3)
    ENST00000593360 ENST00000598517 ENST00000597479 ENST00000601564 ENST00000595958

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HAUS8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HAUS8 (see all 20):
    hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-93 hsa-miR-520d-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): HAUS8 (NM_033417)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAUS8
    Primer
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    OriGene qPCR primer pairs and template standards for HAUS8
    OriGene qSTAR qPCR primer pairs in human, mouse for HAUS8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAUS8
      QuantiTect SYBR Green Assays in human, mouse, rat HAUS8
      QuantiFast Probe-based Assays in human, mouse, rat HAUS8

    Additional mRNA sequence: 

    AK130803.1 AK295994.1 AY211919.1 BC004398.1 BC010176.2 

    9 DOTS entries:

    DT.100670441  DT.91838670  DT.100026622  DT.95099005  DT.100026623  DT.100811233  DT.100829179  DT.75155570 
    DT.91983465 

    Selected AceView cDNA sequences (see all 118):

    BX111116 BU609193 BU620899 BX384290 AA403069 BM563712 BM670601 AW468419 
    AW193727 CA416870 CR615424 CR594374 BQ636008 BF438403 BM909119 CR605479 
    AW405480 BF115627 AA748482 CF127849 BU633720 BG338117 CA393705 CR594325 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HAUS8 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
    SP1:                                -                                                                           
    SP2:                    -           -                       -                                                   
    SP3:                    -           -           -                                                               
    SP4:                                                                                                            
    SP5:                                -                                                                           


    ECgene alternative splicing isoforms for HAUS8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HAUS8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTACATTCA
    HAUS8 Expression
    About this image


    HAUS8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
    HAUS8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HAUS8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.404088
        Custom PCR Arrays for HAUS8
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    QuantiFast Probe-based Assays in human, mouse, rat HAUS8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HAUS8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Haus81 , 5 4HAUS augmin-like complex, subunit 81, 5 66.28(n)1
    57.02(a)1
      8 (34.43 cM)5
    764781  NM_001163042.11  NP_001156514.11 
     712485615 
    chicken
    (Gallus gallus)
    Aves HAUS81 HAUS augmin-like complex, subunit 8 54.3(n)
    46.23(a)
      420137  XM_004948930.1  XP_004948987.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BX845738.12   -- 74.88(n)    BX845738.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-153a8.41 si:ch211-153a8.4 48.17(n)
    36.99(a)
      555850  XM_678494.6  XP_683586.2 


    ENSEMBL Gene Tree for HAUS8 (if available)
    TreeFam Gene Tree for HAUS8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HAUS8 gene

    Find genes that share paralogs with HAUS8           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HAUS8
    PGOHUM00000239934


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HAUS8 (see all 640)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1812249991,2
    --17160122(+) GAGACC/TTCCCG 2 -- ds50010--------
    rs283938291,2
    C--17160126(+) CCTCCC/TGAAGC 2 -- ds50012Minor allele frequency- T:0.12WA 120
    rs169954541,2
    C,F--17160227(+) CCAGTC/TGGGTT 2 -- ds50013Minor allele frequency- T:0.01NA 140
    rs1137364721,2
    C--17160380(+) AAATAAAGT/-  
            
    ATGTC
    2 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs48085571,2
    C,F,A,H--17160564(+) GAAAAC/TGGAGG 2 -- ds500131Minor allele frequency- N:0.00EA NA NS WA CSA 2994
    rs617353601,2
    C,F--17160720(+) AGGGCG/AGGACT 4 /P /L mis14Minor allele frequency- A:0.02NS NA EU 5957
    rs1911585761,2
    C--17160770(+) ATGAAC/TGTGGC 4 T syn10--------
    rs81089961,2
    C,F--17160801(+) CACCCG/AGGTTG 4 /P /L mis1 ese32Minor allele frequency- A:0.00NS NA 4630
    rs2012124721,2
    C--17160808(+) GTTGTC/TGTCCT 4 N D mis10--------
    rs1476107371,2
    C,F--17160825(+) GGGGCG/ATGTTC 4 /T /M mis11Minor allele frequency- A:0.00NA 4550

    HapMap Linkage Disequilibrium report for HAUS8 (17160539 - 17186435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HAUS8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666489CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HAUS8
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613434    OMIM disorders: --


    Find genes that share disorders with HAUS8           About GenesLikeMe


    Export disorders for HAUS8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HAUS8 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with HAUS8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PubMed id 19427217)1, 2, 3 Lawo S....Pelletier L. (Curr. Biol. 2009)
    2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PubMed id 19369198)1, 2 Uehara R....Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    3. Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells. (PubMed id 18362163)1, 2 Wu G.... Lee W.-H. (Mol. Cell. Biol. 2008)
    4. Immunomic analysis of human sarcoma. (PubMed id 12601173)1, 2 Lee S.-Y.... Scanlan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly. (PubMed id 21705324)1 Tsai C.Y....Lee W.H. (J. Biol. Chem. 2011)
    10. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93323 HGNC: 30532 AceView: MGC20533 Ensembl:ENSG00000131351 euGenes: HUgn93323
    ECgene: HAUS8 H-InvDB: HAUS8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HAUS8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HAUS8 gene:
    Search GeneIP for patents involving HAUS8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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