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Aliases for HAUS8 Gene

Aliases for HAUS8 Gene

  • HAUS Augmin-Like Complex, Subunit 8 2 3
  • HICE1 3 4 6
  • HEC1/NDC80-Interacting Centrosome-Associated Protein 1 3 4
  • HEC1/NDC80 Interacting, Centrosome Associated 1 2 3
  • Sarcoma Antigen NY-SAR-48 3 4
  • DGT4 3 6
  • Hec1-Interacting And Centrosome-Associated 1 3
  • HAUS Augmin-Like Complex Subunit 8 3
  • NY-SAR-48 3

External Ids for HAUS8 Gene

Previous Symbols for HAUS8 Gene

  • HICE1

Summaries for HAUS8 Gene

Entrez Gene Summary for HAUS8 Gene

  • HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

GeneCards Summary for HAUS8 Gene

HAUS8 (HAUS Augmin-Like Complex, Subunit 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HAUS8 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS8 Gene

Genomics for HAUS8 Gene

Genomic Location for HAUS8 Gene

Start:
17,049,729 bp from pter
End:
17,075,625 bp from pter
Size:
25,897 bases
Orientation:
Minus strand

Genomic View for HAUS8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAUS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS8 Gene

Regulatory Elements for HAUS8 Gene

Proteins for HAUS8 Gene

  • Protein details for HAUS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT25-HAUS8_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 8
    Protein Accession:
    Q9BT25
    Secondary Accessions:
    • B4DJA7
    • C9JBZ4
    • Q49AC4
    • Q86WF0
    • Q96FX3

    Protein attributes for HAUS8 Gene

    Size:
    410 amino acids
    Molecular mass:
    44857 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect.
    SequenceCaution:
    • Sequence=AAH10176.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO65172.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO65172.1; Type=Frameshift; Positions=222, 241, 269, 278, 279; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS8 Gene

Proteomics data for HAUS8 Gene at MOPED

Post-translational modifications for HAUS8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HAUS8 Gene

No data available for DME Specific Peptides for HAUS8 Gene

Domains for HAUS8 Gene

Gene Families for HAUS8 Gene

HGNC:
  • HAUS :HAUS augmin-like complex subunits

Protein Domains for HAUS8 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for HAUS8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BT25

UniProtKB/Swiss-Prot:

HAUS8_HUMAN
Family:
  • Belongs to the HAUS8 family.:
    • Q9BT25
genes like me logo Genes that share domains with HAUS8: view

Function for HAUS8 Gene

Molecular function for HAUS8 Gene

UniProtKB/Swiss-Prot Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Ontology (GO) - Molecular Function for HAUS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HAUS8: view

miRNA for HAUS8 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HAUS8 Gene

Localization for HAUS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS8 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, primarily cytoplasmic and associates with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, additionally associates with the spindle midzone and midbody, respectively.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAUS8 Gene COMPARTMENTS Subcellular localization image for HAUS8 gene
Compartment Confidence
cytoskeleton 5
nucleus 3

Gene Ontology (GO) - Cellular Components for HAUS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005874 microtubule IEA --
GO:0070652 HAUS complex IDA 19369198
genes like me logo Genes that share ontologies with HAUS8: view

Pathways for HAUS8 Gene

SuperPathways for HAUS8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HAUS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051225 spindle assembly IMP 19369198
GO:0051297 centrosome organization IMP 19427217
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with HAUS8: view

No data available for Pathways by source for HAUS8 Gene

Transcripts for HAUS8 Gene

Unigene Clusters for HAUS8 Gene

HAUS augmin-like complex, subunit 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: -
SP2: - - -
SP3: - - -
SP4:
SP5: -
SP6: - -

Relevant External Links for HAUS8 Gene

GeneLoc Exon Structure for
HAUS8
ECgene alternative splicing isoforms for
HAUS8

Expression for HAUS8 Gene

mRNA expression in normal human tissues for HAUS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HAUS8 Gene

SOURCE GeneReport for Unigene cluster for HAUS8 Gene Hs.404088

genes like me logo Genes that share expressions with HAUS8: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HAUS8 Gene

Orthologs for HAUS8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAUS8 35
  • 98.37 (n)
  • 97.07 (a)
HAUS8 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HAUS8 35
  • 74.27 (n)
  • 68.4 (a)
HICE1 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAUS8 35
  • 77.56 (n)
  • 75.82 (a)
HAUS8 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Haus8 35
  • 66.28 (n)
  • 57.02 (a)
Haus8 16
Haus8 36
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HAUS8 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAUS8 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Haus8 35
  • 67.63 (n)
  • 56.36 (a)
chicken
(Gallus gallus)
Aves HAUS8 35
  • 54.3 (n)
  • 46.23 (a)
HAUS8 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia haus8 35
  • 51.34 (n)
  • 44.51 (a)
zebrafish
(Danio rerio)
Actinopterygii HAUS8 36
  • 26 (a)
OneToOne
si:ch211-153a8.4 35
  • 48.17 (n)
  • 36.99 (a)
Species with no ortholog for HAUS8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS8 Gene

ENSEMBL:
Gene Tree for HAUS8 (if available)
TreeFam:
Gene Tree for HAUS8 (if available)

Paralogs for HAUS8 Gene

Pseudogenes.org Pseudogenes for HAUS8 Gene

genes like me logo Genes that share paralogs with HAUS8: view

No data available for Paralogs for HAUS8 Gene

Variants for HAUS8 Gene

Sequence variations from dbSNP and Humsavar for HAUS8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1048835 -- 17,049,934(-) TTTTT(C/T)TTCAA reference, missense
rs1048839 -- 17,049,844(-) TGAGC(A/C)CTTTA utr-variant-3-prime
rs1130222 - 17,060,075(-) GGGTC(A/C/G/T)GAAAG missense, reference, stop-gained, utr-variant-5-prime
rs1551551 -- 17,059,731(-) TAAAC(A/C)CATCA intron-variant
rs1551552 -- 17,059,730(-) AAACC(C/T)ATCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAUS8 Gene

Variant ID Type Subtype PubMed ID
esv2666489 CNV Deletion 23128226

Relevant External Links for HAUS8 Gene

HapMap Linkage Disequilibrium report
HAUS8
Human Gene Mutation Database (HGMD)
HAUS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAUS8 Gene

Disorders for HAUS8 Gene

No disorders were found for HAUS8 Gene.

No data available for UniProtKB/Swiss-Prot for HAUS8 Gene

Publications for HAUS8 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4
  2. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee S.-Y. … Scanlan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  3. Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells. (PMID: 18362163) Wu G. … Lee W.-H. (Mol. Cell. Biol. 2008) 3 4
  4. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R. … Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for HAUS8 Gene

Sources for HAUS8 Gene

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