HAUS7 Gene
protein-coding GIFtS: 39
GCID: GC0XM152713
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HAUS augmin-like complex, subunit 7(Previous name: UCHL5 interacting protein )
(Previous symbol: UCHL5IP)
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Aliases
for HAUS7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HAUS Augmin-Like Complex, Subunit 71 2 | | 26S Proteasome-Associated UCH37-Interacting Protein 12 3 | | UCHL5IP1 2 3 5 | | X-Linked Protein STS17692 3 | | UIP11 2 3 5 | | HAUS Augmin-Like Complex Subunit 72 | | UCHL5 Interacting Protein1 2 | | UCHL5-Interacting Protein3 |
Export aliases for HAUS7 gene to outside databasesPrevious GC identifers: GC0XM152367 GC0XM141372 |
Summaries
for HAUS7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HAUS7:
This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and isnecessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitinC-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2012)
UniProtKB/Swiss-Prot: HAUS7_HUMAN, Q99871Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis aspart of the HAUS augmin-like complex
|
Genomic Views
for HAUS7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HAUS7 gene promoter:
GR GR-beta MyoD GR-alpha NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HAUS7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAUS7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28HAUS7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM152713: view genomic region
(about GC identifiers)
Start:
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152,713,123 bp from pter |
End:
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152,760,978 bp from pter |
Size:
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47,856 bases |
Orientation:
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minus strand |
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Proteins
for HAUS7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HAUS7_HUMAN, Q99871 (See
protein sequence)Recommended Name: HAUS augmin-like complex subunit 7 Size: 368 amino acids; 40778 Da
Subunit: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and thisinteraction is required for spindle assembly. Binds UCHL5
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes tointerphase centrosomes and to mitotic spindle microtubules
Caution: The gene for this protein is either identical to or adjacent to that of TREX2. Most mRNAs that encode UCHL5IPalso include the N-terminal part of TREX2
Caution: It is uncertain whether Met-1 or Met-11 is the initiator
Sequence caution: Sequence=AAF75785.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAG62338.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA67665.1;Type=Frameshift; Positions=258, 260; Sequence=CAA67665.1; Type=Miscellaneous discrepancy; Note=Chimera. The N-terminalpart of the clone up to position 91 maps to another chromosome;
Secondary accessions: B4DUH6 D3DWT9 Q96HS8 Q9NP54 Q9UFH9Alternative splicing: 3 isoforms: Q99871-1 Q99871-2 Q99871-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HAUS7: NX_Q99871
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99871
HAUS7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_059988.3
ENSEMBL proteins: ENSP00000359230 ENSP00000389431 ENSP00000359229 ENSP00000359239 ENSP00000359231 ENSP00000395447
Human Recombinant Protein Products for HAUS7:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
HAUS7 for ontologies About GeneDecksing
HAUS7 Antibody Products:
Assay Products for HAUS7: |
Protein
Domains /
Families
for HAUS7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q99871 UniProtKB/Swiss-Prot: HAUS7_HUMAN, Q99871Similarity: Belongs to the HAUS7 family |
Function
for HAUS7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: HAUS7_HUMAN, Q99871Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis aspart of the HAUS augmin-like complex Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031996 | thioesterase binding |
ISS | -- |
HAUS7 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS7 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HAUS7 (NM_017518) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HAUS7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAUS7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS7 |
|
Pathways & Interactions
for HAUS7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HAUS7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/541 Interacting proteins for HAUS7 (Q998711, 2, 3 ENSP000003592394) via UniProtKB, MINT, STRING, and/or I2D (see all 541)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
HAUS7 for ontologies About GeneDecksing
|
Drugs & Compounds
for HAUS7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HAUS7
Search CenterWatch for drugs/clinical trials and news about HAUS7
|
Transcripts
for HAUS7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HAUS7 gene (3 alternative transcripts): NM_017518.7 NM_207106.2 NM_207107.2 Unigene Cluster for HAUS7: HAUS augmin-like complex, subunit 7 Hs.170835 [show with all ESTs]Unigene Representative Sequence: NR_07315617 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370211 ENST00000474022 ENST00000460898 ENST00000435662 ENST00000484394
ENST00000477380 ENST00000437046 ENST00000491286 ENST00000490165 ENST00000472228
ENST00000490453 ENST00000464993 ENST00000492596 ENST00000370210 ENST00000370219(uc004fho.2 uc004fhn.2 uc011myq.1)
ENST00000370212 ENST00000421080(uc004fhp.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS7 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HAUS7 (NM_017518) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HAUS7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAUS7 |
Additional cDNA sequence: AF267739.1 AK125219.1 AK296147.1 BC008141.1 NR_073156.1 18 DOTS entries: DT.314044 DT.95378430 DT.121287253 DT.95330868 DT.97855555 DT.121287267 DT.65287713 DT.91756294 DT.97855561 DT.100791882 DT.121287238 DT.101970817 DT.121287281 DT.86849102 DT.95256097 DT.121287240 DT.95142397 DT.97855560
GeneLoc Exon Structure
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Expression
for HAUS7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HAUS7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTCTAGCTA
About this image
See HAUS7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HAUS7
SOURCE GeneReport for Unigene cluster: Hs.170835
UniProtKB/Swiss-Prot: HAUS7_HUMAN, Q99871Tissue specificity: Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels ofexpression in testis and ovary
SABiosciences Custom PCR Arrays for HAUS7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAUS7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HAUS7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAUS7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAUS7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS7 |
Orthologs
for HAUS7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HAUS7 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for HAUS7 (if available)
TreeFam Gene Tree for HAUS7 (if available) |
Paralogs
for HAUS7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HAUS7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HAUS7 (152713123 - 152760978 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HAUS7: --
Locus Specific Mutation Databases (LSDB): HAUS7
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HAUS7 |
|
Disorders
/ Diseases
for HAUS7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 HAUS7 for disorders About MalaCards
HAUS7 for disorders About GeneDecksing
OMIM gene information: 300540
OMIM disorders: --
Export disorders for HAUS7 gene to outside databases
|
Publications
for HAUS7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HAUS7 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with HAUS7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PubMed id 19427217)1, 2, 3 Lawo S....Pelletier L. (2009)
- Identification of two proteins, S14 and UIP1, that interact with UCH37. (PubMed id 11163772)1, 2, 3 Li T.... Teo T.S. (2001)
- The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PubMed id 19369198)1, 2 Uehara R....Goshima G. (2009)
- Human-specific nonsense mutations identified by genome sequence comparisons. (PubMed id 16395595)1, 3 Hahn Y. and Lee B. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expressed STSs and transcription of human Xq28. (PubMed id 9099879)1, 2 Esposito T.... D'Esposito M. (1997)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
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External Searches for HAUS7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HAUS7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HAUS7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HAUS7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HAUS7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HAUS7 gene:
Search GeneIP for patents involving HAUS7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HAUS7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HAUS7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAUS7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAUS7 | | | OriGene Protein Over-expression Lysate for HAUS7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HAUS7 | | OriGene 3'-UTR Clone for HAUS7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HAUS7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HAUS7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HAUS7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAUS7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAUS7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAUS7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAUS7 |
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 | | | HAUS7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS7 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for HAUS7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAUS7 |
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