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Aliases for HAUS7 Gene

Aliases for HAUS7 Gene

  • HAUS Augmin Like Complex Subunit 7 2 3 5
  • 26S Proteasome-Associated UCH37-Interacting Protein 1 3 4
  • UCHL5 Interacting Protein 2 3
  • X-Linked Protein STS1769 3 4
  • UCHL5IP 3 4
  • UIP1 3 4
  • 26S Proteasome-Associated UCH Interacting Protein 1 2
  • HAUS Augmin-Like Complex, Subunit 7 3
  • UCH37 Interacting Protein 1 2
  • UCHL5-Interacting Protein 4

External Ids for HAUS7 Gene

Previous HGNC Symbols for HAUS7 Gene

  • UCHL5IP

Previous GeneCards Identifiers for HAUS7 Gene

  • GC0XM152367
  • GC0XM152713
  • GC0XM141372

Summaries for HAUS7 Gene

Entrez Gene Summary for HAUS7 Gene

  • This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

GeneCards Summary for HAUS7 Gene

HAUS7 (HAUS Augmin Like Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include thioesterase binding.

UniProtKB/Swiss-Prot for HAUS7 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS7 Gene

Genomics for HAUS7 Gene

Regulatory Elements for HAUS7 Gene

Enhancers for HAUS7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HAUS7 on UCSC Golden Path with GeneCards custom track

Genomic Location for HAUS7 Gene

Chromosome:
X
Start:
153,447,665 bp from pter
End:
153,495,525 bp from pter
Size:
47,861 bases
Orientation:
Minus strand

Genomic View for HAUS7 Gene

Genes around HAUS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAUS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAUS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS7 Gene

Proteins for HAUS7 Gene

  • Protein details for HAUS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99871-HAUS7_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 7
    Protein Accession:
    Q99871
    Secondary Accessions:
    • B4DUH6
    • D3DWT9
    • Q96HS8
    • Q9NP54
    • Q9UFH9

    Protein attributes for HAUS7 Gene

    Size:
    368 amino acids
    Molecular mass:
    40778 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Binds UCHL5.
    SequenceCaution:
    • Sequence=AAF75785.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG62338.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA67665.1; Type=Frameshift; Positions=258, 260; Evidence={ECO:0000305}; Sequence=CAA67665.1; Type=Miscellaneous discrepancy; Note=Chimera. The N-terminal part of the clone up to position 91 maps to another chromosome.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS7 Gene

Proteomics data for HAUS7 Gene at MOPED

Post-translational modifications for HAUS7 Gene

  • Ubiquitination at Lys 46, Lys 98, and Lys 341
  • Modification sites at PhosphoSitePlus

Other Protein References for HAUS7 Gene

Antibody Products

No data available for DME Specific Peptides for HAUS7 Gene

Domains & Families for HAUS7 Gene

Gene Families for HAUS7 Gene

Protein Domains for HAUS7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HAUS7 Gene

Graphical View of Domain Structure for InterPro Entry

Q99871

UniProtKB/Swiss-Prot:

HAUS7_HUMAN :
  • Belongs to the HAUS7 family.
Family:
  • Belongs to the HAUS7 family.
genes like me logo Genes that share domains with HAUS7: view

Function for HAUS7 Gene

Molecular function for HAUS7 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Phenotypes for HAUS7 Gene

GenomeRNAi human phenotypes for HAUS7:
genes like me logo Genes that share phenotypes with HAUS7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAUS7 Gene

Localization for HAUS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269 PubMed:19369198, ECO:0000269 PubMed:19427217}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAUS7 Gene COMPARTMENTS Subcellular localization image for HAUS7 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HAUS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005819 spindle IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with HAUS7: view

Pathways & Interactions for HAUS7 Gene

genes like me logo Genes that share pathways with HAUS7: view

Interacting Proteins for HAUS7 Gene

Gene Ontology (GO) - Biological Process for HAUS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with HAUS7: view

No data available for SIGNOR curated interactions for HAUS7 Gene

Drugs & Compounds for HAUS7 Gene

No Compound Related Data Available

Transcripts for HAUS7 Gene

mRNA/cDNA for HAUS7 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HAUS7 Gene

HAUS augmin-like complex, subunit 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS7 Gene

No ASD Table

Relevant External Links for HAUS7 Gene

GeneLoc Exon Structure for
HAUS7
ECgene alternative splicing isoforms for
HAUS7

Expression for HAUS7 Gene

mRNA expression in normal human tissues for HAUS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAUS7 Gene

This gene is overexpressed in Artery - Aorta (x5.4) and Artery - Tibial (x4.7).

Protein differential expression in normal tissues from HIPED for HAUS7 Gene

This gene is overexpressed in Bone (39.2) and Pancreas (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HAUS7 Gene



SOURCE GeneReport for Unigene cluster for HAUS7 Gene Hs.170835

mRNA Expression by UniProt/SwissProt for HAUS7 Gene

Q99871-HAUS7_HUMAN
Tissue specificity: Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.
genes like me logo Genes that share expression patterns with HAUS7: view

Protein tissue co-expression partners for HAUS7 Gene

Primer Products

Orthologs for HAUS7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HAUS7 35
  • 79.3 (n)
  • 74.63 (a)
UCHL5IP 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAUS7 35
  • 81.14 (n)
  • 74.85 (a)
HAUS7 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Haus7 35
  • 74.47 (n)
  • 67.34 (a)
Haus7 16
Haus7 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HAUS7 35
  • 96.92 (n)
  • 95.65 (a)
rat
(Rattus norvegicus)
Mammalia Haus7 35
  • 75.38 (n)
  • 66.76 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HAUS7 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HAUS7 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia haus7 35
  • 51.26 (n)
  • 40.88 (a)
zebrafish
(Danio rerio)
Actinopterygii haus7 35
  • 46.1 (n)
  • 35.13 (a)
haus7 36
  • 29 (a)
OneToOne
Species with no ortholog for HAUS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS7 Gene

ENSEMBL:
Gene Tree for HAUS7 (if available)
TreeFam:
Gene Tree for HAUS7 (if available)

Paralogs for HAUS7 Gene

No data available for Paralogs for HAUS7 Gene

Variants for HAUS7 Gene

Sequence variations from dbSNP and Humsavar for HAUS7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs735889 -- 153,490,828(+) CTCTA(C/G)AAGCT intron-variant
rs762735 -- 153,462,265(+) GCTTG(A/G)GAGCC intron-variant
rs762736 -- 153,463,799(+) CATGC(C/T)GCGCT intron-variant
rs762737 -- 153,463,824(+) CTGCC(A/G)TCTTA intron-variant
rs933190 -- 153,464,618(+) AGCAC(A/G)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAUS7 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
nsv526046 CNV Gain 19592680

Variation tolerance for HAUS7 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HAUS7 Gene

Disorders for HAUS7 Gene

Relevant External Links for HAUS7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAUS7

No disorders were found for HAUS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAUS7 Gene

Publications for HAUS7 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4 67
  2. Human-specific nonsense mutations identified by genome sequence comparisons. (PMID: 16395595) Hahn Y. … Lee B. (Hum. Genet. 2006) 2 3
  3. Identification of two proteins, S14 and UIP1, that interact with UCH37. (PMID: 11163772) Li T. … Teo T.S. (FEBS Lett. 2001) 2 3
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for HAUS7 Gene

Sources for HAUS7 Gene

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