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Aliases for HAUS7 Gene

Aliases for HAUS7 Gene

  • HAUS Augmin-Like Complex, Subunit 7 2 3
  • UCHL5IP 3 4 6
  • UIP1 3 4 6
  • 26S Proteasome-Associated UCH37-Interacting Protein 1 3 4
  • UCHL5 Interacting Protein 2 3
  • X-Linked Protein STS1769 3 4
  • 26S Proteasome-Associated UCH Interacting Protein 1 2
  • HAUS Augmin-Like Complex Subunit 7 3
  • UCH37 Interacting Protein 1 2
  • UCHL5-Interacting Protein 4

External Ids for HAUS7 Gene

Previous HGNC Symbols for HAUS7 Gene


Previous GeneCards Identifiers for HAUS7 Gene

  • GC0XM152367
  • GC0XM152713
  • GC0XM141372

Summaries for HAUS7 Gene

Entrez Gene Summary for HAUS7 Gene

  • This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

GeneCards Summary for HAUS7 Gene

HAUS7 (HAUS Augmin-Like Complex, Subunit 7) is a Protein Coding gene. GO annotations related to this gene include thioesterase binding.

UniProtKB/Swiss-Prot for HAUS7 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS7 Gene

Genomics for HAUS7 Gene

Regulatory Elements for HAUS7 Gene

Genomic Location for HAUS7 Gene

153,447,665 bp from pter
153,495,525 bp from pter
47,861 bases
Minus strand

Genomic View for HAUS7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAUS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS7 Gene

Proteins for HAUS7 Gene

  • Protein details for HAUS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HAUS augmin-like complex subunit 7
    Protein Accession:
    Secondary Accessions:
    • B4DUH6
    • D3DWT9
    • Q96HS8
    • Q9NP54
    • Q9UFH9

    Protein attributes for HAUS7 Gene

    368 amino acids
    Molecular mass:
    40778 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Binds UCHL5.
    • Sequence=AAF75785.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG62338.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA67665.1; Type=Frameshift; Positions=258, 260; Evidence={ECO:0000305}; Sequence=CAA67665.1; Type=Miscellaneous discrepancy; Note=Chimera. The N-terminal part of the clone up to position 91 maps to another chromosome.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS7 Gene


neXtProt entry for HAUS7 Gene

Proteomics data for HAUS7 Gene at MOPED

Post-translational modifications for HAUS7 Gene

  • Ubiquitination at Lys46, Lys98, and Lys341
  • Modification sites at PhosphoSitePlus

Other Protein References for HAUS7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HAUS7 Gene

Domains for HAUS7 Gene

Gene Families for HAUS7 Gene

  • HAUS :HAUS augmin-like complex subunits

Protein Domains for HAUS7 Gene


Suggested Antigen Peptide Sequences for HAUS7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q99871
  • Belongs to the HAUS7 family.
genes like me logo Genes that share domains with HAUS7: view

Function for HAUS7 Gene

Molecular function for HAUS7 Gene

UniProtKB/Swiss-Prot Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Ontology (GO) - Molecular Function for HAUS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031996 thioesterase binding ISS --
genes like me logo Genes that share ontologies with HAUS7: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HAUS7 Gene

Localization for HAUS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.

Subcellular locations from

Jensen Localization Image for HAUS7 Gene COMPARTMENTS Subcellular localization image for HAUS7 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
plasma membrane 4
cytosol 3
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HAUS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005819 spindle IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with HAUS7: view

Pathways for HAUS7 Gene

SuperPathways for HAUS7 Gene

No Data Available

Interacting Proteins for HAUS7 Gene

Gene Ontology (GO) - Biological Process for HAUS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051225 spindle assembly IMP 19369198
GO:0051297 centrosome organization IMP 19427217
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with HAUS7: view

No data available for Pathways by source for HAUS7 Gene

Transcripts for HAUS7 Gene

mRNA/cDNA for HAUS7 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HAUS7 Gene

HAUS augmin-like complex, subunit 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS7 Gene

No ASD Table

Relevant External Links for HAUS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HAUS7 Gene

mRNA expression in normal human tissues for HAUS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAUS7 Gene

This gene is overexpressed in Artery - Aorta (5.4) and Artery - Tibial (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HAUS7 Gene

SOURCE GeneReport for Unigene cluster for HAUS7 Gene Hs.170835

mRNA Expression by UniProt/SwissProt for HAUS7 Gene

Tissue specificity: Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.
genes like me logo Genes that share expressions with HAUS7: view

Orthologs for HAUS7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HAUS7 35
  • 96.92 (n)
  • 95.65 (a)
(Bos Taurus)
Mammalia HAUS7 35
  • 79.3 (n)
  • 74.63 (a)
  • 69 (a)
(Canis familiaris)
Mammalia HAUS7 35
  • 81.14 (n)
  • 74.85 (a)
HAUS7 36
  • 71 (a)
(Mus musculus)
Mammalia Haus7 35
  • 74.47 (n)
  • 67.34 (a)
Haus7 16
Haus7 36
  • 65 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
-- 36
  • 28 (a)
-- 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia HAUS7 36
  • 42 (a)
(Rattus norvegicus)
Mammalia Haus7 35
  • 75.38 (n)
  • 66.76 (a)
(Anolis carolinensis)
Reptilia HAUS7 36
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia haus7 35
  • 51.26 (n)
  • 40.88 (a)
(Danio rerio)
Actinopterygii haus7 35
  • 46.1 (n)
  • 35.13 (a)
haus7 36
  • 29 (a)
Species with no ortholog for HAUS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS7 Gene

Gene Tree for HAUS7 (if available)
Gene Tree for HAUS7 (if available)

Paralogs for HAUS7 Gene

No data available for Paralogs for HAUS7 Gene

Variants for HAUS7 Gene

Sequence variations from dbSNP and Humsavar for HAUS7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs17433 -- 153,483,730(+) CTTCC(C/T)TCTGT intron-variant
rs17434 -- 153,483,951(+) CATGC(A/C)TGtcc intron-variant
rs735889 -- 153,490,828(+) CTCTA(C/G)AAGCT intron-variant
rs743645 -- 153,479,518(+) TGTGC(A/G)CAGAC intron-variant
rs762735 -- 153,462,265(+) GCTTG(A/G)GAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAUS7 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
nsv526046 CNV Gain 19592680

Relevant External Links for HAUS7 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAUS7 Gene

Disorders for HAUS7 Gene

No disorders were found for HAUS7 Gene.

No data available for UniProtKB/Swiss-Prot for HAUS7 Gene

Publications for HAUS7 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4
  2. Identification of two proteins, S14 and UIP1, that interact with UCH37. (PMID: 11163772) Li T. … Teo T.S. (FEBS Lett. 2001) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Expressed STSs and transcription of human Xq28. (PMID: 9099879) Esposito T. … D'Esposito M. (Gene 1997) 3 4
  5. Human-specific nonsense mutations identified by genome sequence comparisons. (PMID: 16395595) Hahn Y. … Lee B. (Hum. Genet. 2006) 2 3

Products for HAUS7 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HAUS7
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HAUS7
    • Block miRNA regulation of HAUS7 using miScript Target Protectors

    Sources for HAUS7 Gene

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