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Aliases for HAUS7 Gene

Aliases for HAUS7 Gene

  • HAUS Augmin Like Complex Subunit 7 2 3 5
  • 26S Proteasome-Associated UCH37-Interacting Protein 1 3 4
  • UCHL5 Interacting Protein 2 3
  • X-Linked Protein STS1769 3 4
  • UCHL5IP 3 4
  • UIP1 3 4
  • 26S Proteasome-Associated UCH Interacting Protein 1 2
  • HAUS Augmin-Like Complex Subunit 7 3
  • UCH37 Interacting Protein 1 2
  • UCHL5-Interacting Protein 4

External Ids for HAUS7 Gene

Previous HGNC Symbols for HAUS7 Gene

  • UCHL5IP

Previous GeneCards Identifiers for HAUS7 Gene

  • GC0XM152367
  • GC0XM152713
  • GC0XM141372

Summaries for HAUS7 Gene

Entrez Gene Summary for HAUS7 Gene

  • This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

GeneCards Summary for HAUS7 Gene

HAUS7 (HAUS Augmin Like Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include thioesterase binding.

UniProtKB/Swiss-Prot for HAUS7 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS7 Gene

Genomics for HAUS7 Gene

Regulatory Elements for HAUS7 Gene

Enhancers for HAUS7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG153493 0.9 ENCODE dbSUPER 11.9 +0.4 379 3.0 ZNF263 CTCF NFIB NRF1 ARID4B REST ZIC2 RAD21 GLIS2 POLR2A HAUS7 TREX2 BGN
GH0XG153491 1.1 Ensembl ENCODE dbSUPER 9.1 +3.6 3601 1.5 CTCF ZNF341 BHLHE40 BCL6 RAD21 ZIC2 HNRNPL HAUS7 BGN LOC105373381
GH0XG153498 0.7 Ensembl dbSUPER 0.7 -3.2 -3176 0.6 ZNF341 GLIS1 ZIC2 ZFP92 HAUS7 ATP2B3
GH0XG153507 1.1 ENCODE dbSUPER 0.4 -12.2 -12173 0.2 CTCF TFAP4 RB1 ZSCAN4 ARID4B ZIC2 ZNF2 RAD21 ZFHX2 PATZ1 ATP2B3 HAUS7
GH0XG153497 0.6 Ensembl dbSUPER 0.7 -2.5 -2476 0.4 ZNF341 HAUS7 ATP2B3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HAUS7 on UCSC Golden Path with GeneCards custom track

Promoters for HAUS7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249550 -75 1601 ZNF263 CTCF NFIB NRF1 REST ZIC2 RAD21 GLIS2 POLR2A GLIS1

Genomic Location for HAUS7 Gene

Chromosome:
X
Start:
153,447,665 bp from pter
End:
153,495,525 bp from pter
Size:
47,861 bases
Orientation:
Minus strand

Genomic View for HAUS7 Gene

Genes around HAUS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAUS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAUS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS7 Gene

Proteins for HAUS7 Gene

  • Protein details for HAUS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99871-HAUS7_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 7
    Protein Accession:
    Q99871
    Secondary Accessions:
    • B4DUH6
    • D3DWT9
    • Q96HS8
    • Q9NP54
    • Q9UFH9

    Protein attributes for HAUS7 Gene

    Size:
    368 amino acids
    Molecular mass:
    40778 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Binds UCHL5.
    SequenceCaution:
    • Sequence=AAF75785.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG62338.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA67665.1; Type=Frameshift; Positions=258, 260; Evidence={ECO:0000305}; Sequence=CAA67665.1; Type=Miscellaneous discrepancy; Note=Chimera. The N-terminal part of the clone up to position 91 maps to another chromosome.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS7 Gene

Post-translational modifications for HAUS7 Gene

  • Ubiquitination at isoforms=2, 346, isoforms=2, 398, and isoforms=2341
  • Modification sites at PhosphoSitePlus

Other Protein References for HAUS7 Gene

No data available for DME Specific Peptides for HAUS7 Gene

Domains & Families for HAUS7 Gene

Gene Families for HAUS7 Gene

Protein Domains for HAUS7 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for HAUS7 Gene

Graphical View of Domain Structure for InterPro Entry

Q99871

UniProtKB/Swiss-Prot:

HAUS7_HUMAN :
  • Belongs to the HAUS7 family.
Family:
  • Belongs to the HAUS7 family.
genes like me logo Genes that share domains with HAUS7: view

Function for HAUS7 Gene

Molecular function for HAUS7 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Ontology (GO) - Molecular Function for HAUS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031996 thioesterase binding ISS --
genes like me logo Genes that share ontologies with HAUS7: view

Phenotypes for HAUS7 Gene

GenomeRNAi human phenotypes for HAUS7:
genes like me logo Genes that share phenotypes with HAUS7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAUS7 Gene

Localization for HAUS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269 PubMed:19369198, ECO:0000269 PubMed:19427217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAUS7 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for HAUS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HAUS7: view

Pathways & Interactions for HAUS7 Gene

genes like me logo Genes that share pathways with HAUS7: view

Interacting Proteins for HAUS7 Gene

Gene Ontology (GO) - Biological Process for HAUS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007098 centrosome cycle IMP 19427217
GO:0051225 spindle assembly IMP 19369198
genes like me logo Genes that share ontologies with HAUS7: view

No data available for SIGNOR curated interactions for HAUS7 Gene

Drugs & Compounds for HAUS7 Gene

No Compound Related Data Available

Transcripts for HAUS7 Gene

mRNA/cDNA for HAUS7 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HAUS7 Gene

HAUS augmin-like complex, subunit 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS7 Gene

No ASD Table

Relevant External Links for HAUS7 Gene

GeneLoc Exon Structure for
HAUS7
ECgene alternative splicing isoforms for
HAUS7

Expression for HAUS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HAUS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAUS7 Gene

This gene is overexpressed in Artery - Aorta (x5.4) and Artery - Tibial (x4.7).

Protein differential expression in normal tissues from HIPED for HAUS7 Gene

This gene is overexpressed in Bone (39.2) and Pancreas (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HAUS7 Gene



Protein tissue co-expression partners for HAUS7 Gene

NURSA nuclear receptor signaling pathways regulating expression of HAUS7 Gene:

HAUS7

SOURCE GeneReport for Unigene cluster for HAUS7 Gene:

Hs.170835

mRNA Expression by UniProt/SwissProt for HAUS7 Gene:

Q99871-HAUS7_HUMAN
Tissue specificity: Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.

Evidence on tissue expression from TISSUES for HAUS7 Gene

  • Intestine(4.2)
  • Nervous system(4.2)
  • Bone(4)
genes like me logo Genes that share expression patterns with HAUS7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HAUS7 Gene

Orthologs for HAUS7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAUS7 34
  • 96.92 (n)
dog
(Canis familiaris)
Mammalia HAUS7 34 35
  • 81.14 (n)
cow
(Bos Taurus)
Mammalia HAUS7 34
  • 79.3 (n)
UCHL5IP 35
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Haus7 34
  • 75.38 (n)
mouse
(Mus musculus)
Mammalia Haus7 34 16 35
  • 74.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HAUS7 35
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
-- 35
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HAUS7 35
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia haus7 34
  • 51.26 (n)
zebrafish
(Danio rerio)
Actinopterygii haus7 34 35
  • 46.1 (n)
Species where no ortholog for HAUS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS7 Gene

ENSEMBL:
Gene Tree for HAUS7 (if available)
TreeFam:
Gene Tree for HAUS7 (if available)

Paralogs for HAUS7 Gene

No data available for Paralogs for HAUS7 Gene

Variants for HAUS7 Gene

Sequence variations from dbSNP and Humsavar for HAUS7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000275678 -- 153,467,256(+) CCACT(C/T)AGCGC intron-variant
rs1000310656 -- 153,493,604(+) CCCCT(A/G)GTTTC intron-variant, upstream-variant-2KB
rs1000359306 -- 153,448,287(+) ACTAT(C/T)GCAAG intron-variant, upstream-variant-2KB
rs1000381979 -- 153,466,514(+) CAACA(A/C)TAGGT intron-variant
rs1000481498 -- 153,474,334(+) ATCCT(A/G)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAUS7 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv3575022 CNV loss 25503493
esv3577532 CNV gain 25503493
nsv522600 CNV gain 19592680
nsv526046 CNV gain 19592680

Variation tolerance for HAUS7 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAUS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAUS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAUS7 Gene

Disorders for HAUS7 Gene

Relevant External Links for HAUS7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAUS7

No disorders were found for HAUS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAUS7 Gene

Publications for HAUS7 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4 64
  2. Identification of two proteins, S14 and UIP1, that interact with UCH37. (PMID: 11163772) Li T. … Teo T.S. (FEBS Lett. 2001) 2 3 4 64
  3. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R. … Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 64
  4. Human-specific nonsense mutations identified by genome sequence comparisons. (PMID: 16395595) Hahn Y. … Lee B. (Hum. Genet. 2006) 2 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for HAUS7 Gene

Sources for HAUS7 Gene

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