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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HAUS6 Gene

protein-coding   GIFtS: 50
GCID: GC09M019047

HAUS augmin-like complex, subunit 6

(Previous names: family with sequence similarity 29, member A )
(Previous symbol: FAM29A)
 Explore 2 diseases affiliated with
HAUS6 via our new
 Human Malady Compendium 
Biological research products
for HAUS6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
HAUS Augmin-Like Complex, Subunit 61 2     FLJ200601
FAM29A1 2 3 5     Dgt62
Family With Sequence Similarity 29, Member A1 2     Dgt62
KIAA15741 3     Dim Gamma-Tubulin Homolog2
DGT63 5     HAUS Augmin-Like Complex Subunit 62

External Ids:    HGNC: 259481   Entrez Gene: 548012   Ensembl: ENSG000001478747   OMIM: 6134335   UniProtKB: Q7Z4H73   

Export aliases for HAUS6 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HAUS6:
The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule
attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome
congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are
located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different
protein isoforms. (provided by RefSeq, Aug 2012)

UniProtKB/Swiss-Prot: HAUS6_HUMAN, Q7Z4H7
Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as
part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of
NEDD1 and gamma-tubulin

Gene Wiki entry for HAUS6 (FAM29A)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HAUS6 gene promoter:
         C/EBPbeta   AML1a   HNF-1A   SRY   FAC1   FOXC1   ARP-1   Pax-4a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAUS6 promoter sequence
   Search SABiosciences Chromatin IP Primers for HAUS6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAUS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.1   Ensembl cytogenetic band:  9p22.1   HGNC cytogenetic band: 9p22.1

HAUS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAUS6 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M019047:  view genomic region     (about GC identifiers)

Start:
19,053,141 bp from pter      End:
19,103,117 bp from pter
Size:
49,977 bases      Orientation:
minus strand

1 alternative location:
Chr7+,CRA_TCAG 53,260,352-53,939,994     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HAUS6_HUMAN, Q7Z4H7 (See protein sequence)
Recommended Name: HAUS augmin-like complex subunit 6  
Size: 955 amino acids; 108621 Da
Subunit: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this
interaction is required for spindle assembly. Interacts with PLK1 and NEDD1
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, centrosome.
Note=Localizes to interphase centrosomes and to mitotic spindle microtubules
Sequence caution: Sequence=AAH26178.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=AAI11042.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA90922.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14334.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAB14388.1; Type=Erroneous initiation; Note=Translation N-terminally
extended; Sequence=BAG63294.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KPK4 B4DX82 Q05CG1 Q14CB6 Q14CD9 Q2TA91 Q6IQ10 Q6NZX5 Q8IZQ4 Q96FN0 Q9H950
Q9H998 Q9HCJ8 Q9NXT8
Alternative splicing: 3 isoforms:  Q7Z4H7-1   Q7Z4H7-2   Q7Z4H7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HAUS6: NX_Q7Z4H7

Post-translational modifications:

  • Phosphorylated during mitosis1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z4H7

  • HAUS6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257819.1  NP_060115.3  

    ENSEMBL proteins: 
     ENSP00000369871   ENSP00000369865   ENSP00000409615  

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    Uscn Proteins for HAUS6

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005819spindle IEA--


    HAUS6 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HAUS6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026797 HAUS_6

    Graphical View of Domain Structure for InterPro Entry Q7Z4H7

    ProtoNet protein and cluster: Q7Z4H7

    UniProtKB/Swiss-Prot: HAUS6_HUMAN, Q7Z4H7
    Similarity: Belongs to the HAUS6 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HAUS6_HUMAN, Q7Z4H7
    Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as
    part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of
    NEDD1 and gamma-tubulin

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--


    HAUS6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HAUS6:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HAUS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for HAUS6 (Q7Z4H72, 3 ENSP000003698714) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8201867 I2D: score=1 STRING: ENSP00000250416
    HAUS2Q9NVX03, ENSP000002603724I2D: score=1 STRING: ENSP00000260372
    HAUS7Q998713, ENSP000003592394I2D: score=1 STRING: ENSP00000359239
    HAUS1Q96CS23, ENSP000002820584I2D: score=1 STRING: ENSP00000282058
    HAUS3Q68CZ63, ENSP000002437064I2D: score=1 STRING: ENSP00000243706
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0051225spindle assembly IMP19427217
    GO:0051297centrosome organization IMP19427217
    GO:0051301cell division IEA--


    HAUS6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HAUS6
    Search CenterWatch for drugs/clinical trials and news about HAUS6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HAUS6 gene (2 alternative transcripts): 
    NM_001270890.1  NM_017645.4  

    Unigene Cluster for HAUS6:

    HAUS augmin-like complex, subunit 6
    Hs.533468  [show with all ESTs]
    Unigene Representative Sequence: NM_017645
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380502(uc011lmz.2 uc003znl.1 uc022bdv.1 uc003znk.3)
    ENST00000380496(uc003znm.1) ENST00000415524

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    hsa-miR-302d hsa-miR-520e hsa-miR-4328 hsa-miR-302e hsa-miR-519a hsa-miR-3916 hsa-miR-3125 hsa-miR-3167
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    Additional cDNA sequence: 

    AB046794.1 AF533709.1 AF537091.1 AK000067.1 AK022964.1 AK023068.1 AK056458.1 AK225209.1 
    AK301852.1 AL832495.1 BC010632.1 BC026178.1 BC065935.1 BC071625.1 BC111041.1 BC113981.1 
    BC114492.1 

    9 DOTS entries:

    DT.309225  DT.100777674  DT.102828029  DT.99973924  DT.100722075  DT.100736214  DT.121051178  DT.100777675 
    DT.101974607 

    24/141 AceView cDNA sequences (see all 141):

    AI379102 BC065935 CB852613 AA284001 BQ961552 AI590947 AF537091 AK023068 
    AA830203 BM821351 AB046794 NM_017645 BI463635 AI917312 BM790193 BU183722 
    BE467619 AI368217 AI743579 AW189076 CF264976 BQ921432 BQ422992 AA287858 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HAUS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATGATTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    HAUS6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HAUS6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HAUS6

    SOURCE GeneReport for Unigene cluster: Hs.533468
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HAUS6 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Haus61 , 5 HAUS augmin-like complex, subunit 61, 5 78.43(n)1
    65.8(a)1
      4 (40.69 cM)5
    2303761  NM_173400.21  NP_775576.21 
     865788555 
    chicken
    (Gallus gallus)
    Aves HAUS61 HAUS augmin-like complex, subunit 6 53.87(n)
    36.83(a)
      427238  NM_001031421.1  NP_001026592.1 
    lizard
    (Anolis carolinensis)
    Reptilia HAUS66
    --
    42(a)
    1 ↔ 1
    2(64605921-64623839)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.93932 Xenopus laevis transcribed sequences 80.2(n)    BJ096031.1 
    zebrafish
    (Danio rerio)
    Actinopterygii haus61 HAUS augmin-like complex, subunit 6 46.55(n)
    32.81(a)
      558814  NM_001079974.1  NP_001073443.1 


    ENSEMBL Gene Tree for HAUS6 (if available)
    TreeFam Gene Tree for HAUS6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HAUS6 gene

    HAUS6 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for HAUS6
    PGOHUM00000259635 PGOHUM00000233230 PGOHUM00000233234


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1281 NCBI SNPs in HAUS6 are shown (see all 1281    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154749771,2
    --19052669(+) AGAGCG/AAAGAG 2 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1902575601,2
    --19052794(+) GTTCAC/TTAAAC 2 -- ds50010--------
    rs22915031,2
    C,F,O,A,H,--19052923(-) AGTTTT/ACACAT 2 -- ds5001113Minor allele frequency- A:0.46EA NS NA PA EU CA WA CSA 8328
    rs1828368991,2
    --19052930(+) AACTGA/TCAGTA 2 -- ds50010--------
    rs726964471,2
    C,F,--19052986(+) ATCTAG/CTAATT 2 -- ds50011Minor allele frequency- C:0.05NA 120
    rs70458441,2
    C,F,A,H,--19053114(+) TTTGAG/TATTAT 2 -- ds500125Minor allele frequency- T:0.42NS EA NA WA CSA 2532
    rs134404141,2
    C,H,--19053141(+) CCAGAT/GAGTAT 2 -- ut314Minor allele frequency- G:0.00NS EA 390
    rs1882133501,2
    --19053242(+) CTATTA/CACAAT 2 -- ut310--------
    rs70313921,2
    C,F,A,H,--19053247(+) CACAAT/CGCATA 2 -- ut31 ese319Minor allele frequency- C:0.10NA NS EA 2362
    rs1512547871,2
    --19053279(+) GCAACC/TATGTA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HAUS6 (19053141 - 19103117 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HAUS6
         1 CNV: 52762

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HAUS6 for disorders           About GeneDecksing

    OMIM gene information: 613433    OMIM disorders: --

    2 diseases for HAUS6:    About MalaCards
    pulmonary tuberculosis    tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: HAUS6 (1 document)

    Export disorders for HAUS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HAUS6 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with HAUS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PubMed id 19427217)1, 2, 3 Lawo S....Pelletier L. (2009)
    2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PubMed id 19369198)1, 2 Uehara R....Goshima G. (2009)
    4. FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. (PubMed id 19029337)1, 2 Zhu H.... Fang G. (2008)
    5. Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. (PubMed id 18443220)1, 2 Goshima G.... Vale R.D. (2008)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. A genome wide association study of pulmonary tuberculo sis susceptibility in Indonesians. (PubMed id 22239941)1 Png E....Seielstad M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54801 HGNC: 25948 AceView: FAM29A Ensembl:ENSG00000147874 euGenes: HUgn54801
    ECgene: HAUS6 H-InvDB: HAUS6

    (According to HUGE)
    About This Section
    HUGE: KIAA1574

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HAUS6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HAUS6 gene:
    Search GeneIP for patents involving HAUS6

    GeneCards and IP:
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