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Aliases for HAUS6 Gene

Aliases for HAUS6 Gene

  • HAUS Augmin Like Complex Subunit 6 2 3 5
  • Family With Sequence Similarity 29, Member A 2 3
  • FAM29A 3 4
  • Dgt6 3 4
  • HAUS Augmin-Like Complex Subunit 6 3
  • Dim Gamma-Tubulin Homolog 3
  • KIAA1574 4

External Ids for HAUS6 Gene

Previous HGNC Symbols for HAUS6 Gene

  • FAM29A

Summaries for HAUS6 Gene

Entrez Gene Summary for HAUS6 Gene

  • The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for HAUS6 Gene

HAUS6 (HAUS Augmin Like Complex Subunit 6) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for HAUS6 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin.

Gene Wiki entry for HAUS6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS6 Gene

Genomics for HAUS6 Gene

Regulatory Elements for HAUS6 Gene

Enhancers for HAUS6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G019123 1.6 FANTOM5 ENCODE dbSUPER 19.7 -24.3 -24289 6.9 HNRNPUL1 HDGF FOXA2 PKNOX1 MLX ARID4B SIN3A DMAP1 YBX1 FEZF1 HAUS6 PLIN2 ACER2 GC09M019109
GH09G018975 1.3 Ensembl ENCODE 23.5 +126.5 126468 1.7 PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF302 ZNF263 SP3 ZNF662 REST ENSG00000273226 HAUS6 RPS6P10 RRAGA PIR34932 LOC105375985
GH09G019180 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -80.7 -80696 6.0 HDGF FOXA2 MLX SIN3A ARID4B GATA2 FOS SP5 JUNB TBX21 DENND4C PLIN2 HAUS6 ENSG00000232978 RPS6P10
GH09G019150 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -50.0 -50033 5.5 FOXA2 PKNOX1 CREB3L1 MLX ARNT ZFP64 ARID4B DMAP1 YY1 SLC30A9 RRAGA HAUS6 SAXO1 PSMC3P1 PLIN2 RPS6P10
GH09G019048 1.1 ENCODE 18.8 +53.5 53485 3.0 HDGF FOXA2 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 HAUS6 PIR46202 RRAGA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HAUS6 on UCSC Golden Path with GeneCards custom track

Promoters for HAUS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000233705 519 2001 HDGF FOXA2 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207

Genomic Location for HAUS6 Gene

Chromosome:
9
Start:
19,053,137 bp from pter
End:
19,103,119 bp from pter
Size:
49,983 bases
Orientation:
Minus strand

Genomic View for HAUS6 Gene

Genes around HAUS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAUS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAUS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS6 Gene

Proteins for HAUS6 Gene

  • Protein details for HAUS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4H7-HAUS6_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 6
    Protein Accession:
    Q7Z4H7
    Secondary Accessions:
    • B3KPK4
    • B4DX82
    • Q05CG1
    • Q14CB6
    • Q14CD9
    • Q2TA91
    • Q6IQ10
    • Q6NZX5
    • Q8IZQ4
    • Q96FN0
    • Q9H950
    • Q9H998
    • Q9HCJ8
    • Q9NXT8

    Protein attributes for HAUS6 Gene

    Size:
    955 amino acids
    Molecular mass:
    108621 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (PubMed:19369198, PubMed:19427217). Interacts with PLK1, NEDD1 and gamma-tubulin (PubMed:19029337).
    SequenceCaution:
    • Sequence=AAH26178.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI11042.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA90922.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14334.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14388.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG63294.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS6 Gene

Post-translational modifications for HAUS6 Gene

  • Phosphorylated during mitosis.
  • Ubiquitination at posLast=199199, isoforms=3598, posLast=694694, posLast=704704, and posLast=847847
  • Modification sites at PhosphoSitePlus

Other Protein References for HAUS6 Gene

No data available for DME Specific Peptides for HAUS6 Gene

Domains & Families for HAUS6 Gene

Gene Families for HAUS6 Gene

Protein Domains for HAUS6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HAUS6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z4H7

UniProtKB/Swiss-Prot:

HAUS6_HUMAN :
  • Belongs to the HAUS6 family.
Family:
  • Belongs to the HAUS6 family.
genes like me logo Genes that share domains with HAUS6: view

Function for HAUS6 Gene

Molecular function for HAUS6 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin.

Gene Ontology (GO) - Molecular Function for HAUS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HAUS6: view
genes like me logo Genes that share phenotypes with HAUS6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HAUS6 Gene

Localization for HAUS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS6 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269 PubMed:19369198, ECO:0000269 PubMed:19427217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAUS6 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HAUS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IDA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with HAUS6: view

Pathways & Interactions for HAUS6 Gene

genes like me logo Genes that share pathways with HAUS6: view

Gene Ontology (GO) - Biological Process for HAUS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007098 centrosome cycle IMP 19427217
GO:0051225 spindle assembly IEA,IMP 19369198
genes like me logo Genes that share ontologies with HAUS6: view

No data available for SIGNOR curated interactions for HAUS6 Gene

Drugs & Compounds for HAUS6 Gene

No Compound Related Data Available

Transcripts for HAUS6 Gene

Unigene Clusters for HAUS6 Gene

HAUS augmin-like complex, subunit 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS6 Gene

No ASD Table

Relevant External Links for HAUS6 Gene

GeneLoc Exon Structure for
HAUS6
ECgene alternative splicing isoforms for
HAUS6

Expression for HAUS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HAUS6 Gene

Protein differential expression in normal tissues from HIPED for HAUS6 Gene

This gene is overexpressed in Testis (28.5), Heart (18.8), Ovary (8.9), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HAUS6 Gene



Protein tissue co-expression partners for HAUS6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HAUS6 Gene:

HAUS6

SOURCE GeneReport for Unigene cluster for HAUS6 Gene:

Hs.533468

Evidence on tissue expression from TISSUES for HAUS6 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
  • Skin(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with HAUS6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAUS6 Gene

Orthologs for HAUS6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAUS6 34 35
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia HAUS6 34 35
  • 86.23 (n)
cow
(Bos Taurus)
Mammalia HAUS6 34 35
  • 85.62 (n)
mouse
(Mus musculus)
Mammalia Haus6 34 16 35
  • 78.39 (n)
oppossum
(Monodelphis domestica)
Mammalia HAUS6 35
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAUS6 35
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves HAUS6 34 35
  • 54.06 (n)
lizard
(Anolis carolinensis)
Reptilia HAUS6 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia haus6 34
  • 52.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9393 34
zebrafish
(Danio rerio)
Actinopterygii haus6 34 35
  • 46.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6744 35
  • 20 (a)
OneToOne
Species where no ortholog for HAUS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS6 Gene

ENSEMBL:
Gene Tree for HAUS6 (if available)
TreeFam:
Gene Tree for HAUS6 (if available)

Paralogs for HAUS6 Gene

Pseudogenes.org Pseudogenes for HAUS6 Gene

genes like me logo Genes that share paralogs with HAUS6: view

No data available for Paralogs for HAUS6 Gene

Variants for HAUS6 Gene

Sequence variations from dbSNP and Humsavar for HAUS6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000010902 -- 19,062,902(+) CTCAA(A/C)TGTTC intron-variant
rs1000019067 -- 19,086,447(+) GAAAC(A/T)CTATC intron-variant
rs1000026334 -- 19,094,347(+) CAATG(C/T)TTTCG upstream-variant-2KB, reference, synonymous-codon
rs1000059650 -- 19,098,462(+) TATAT(A/G)AGGGA intron-variant
rs1000069868 -- 19,086,257(+) AGTGA(G/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAUS6 Gene

Variant ID Type Subtype PubMed ID
esv2764156 CNV loss 21179565
nsv1161845 CNV duplication 26073780

Variation tolerance for HAUS6 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAUS6 Gene

Human Gene Mutation Database (HGMD)
HAUS6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAUS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAUS6 Gene

Disorders for HAUS6 Gene

Relevant External Links for HAUS6

Genetic Association Database (GAD)
HAUS6
Human Genome Epidemiology (HuGE) Navigator
HAUS6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAUS6

No disorders were found for HAUS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAUS6 Gene

Publications for HAUS6 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R. … Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 64
  5. Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. (PMID: 18443220) Goshima G. … Vale R.D. (J. Cell Biol. 2008) 3 4 64

Products for HAUS6 Gene

Sources for HAUS6 Gene

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