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Aliases for HAUS6 Gene

Aliases for HAUS6 Gene

  • HAUS Augmin-Like Complex, Subunit 6 2 3
  • FAM29A 3 4 6
  • Dgt6 3 4 6
  • Family With Sequence Similarity 29, Member A 2 3
  • HAUS Augmin-Like Complex Subunit 6 3
  • Dim Gamma-Tubulin Homolog 3
  • KIAA1574 4

External Ids for HAUS6 Gene

Previous HGNC Symbols for HAUS6 Gene

  • FAM29A

Summaries for HAUS6 Gene

Entrez Gene Summary for HAUS6 Gene

  • The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for HAUS6 Gene

HAUS6 (HAUS Augmin-Like Complex, Subunit 6) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HAUS6 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin.

Gene Wiki entry for HAUS6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS6 Gene

Genomics for HAUS6 Gene

Regulatory Elements for HAUS6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HAUS6 Gene

Start:
19,053,137 bp from pter
End:
19,103,119 bp from pter
Size:
49,983 bases
Orientation:
Minus strand

Genomic View for HAUS6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAUS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS6 Gene

Proteins for HAUS6 Gene

  • Protein details for HAUS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4H7-HAUS6_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 6
    Protein Accession:
    Q7Z4H7
    Secondary Accessions:
    • B3KPK4
    • B4DX82
    • Q05CG1
    • Q14CB6
    • Q14CD9
    • Q2TA91
    • Q6IQ10
    • Q6NZX5
    • Q8IZQ4
    • Q96FN0
    • Q9H950
    • Q9H998
    • Q9HCJ8
    • Q9NXT8

    Protein attributes for HAUS6 Gene

    Size:
    955 amino acids
    Molecular mass:
    108621 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Interacts with PLK1 and NEDD1.
    SequenceCaution:
    • Sequence=AAH26178.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI11042.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA90922.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14334.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14388.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG63294.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS6 Gene

Proteomics data for HAUS6 Gene at MOPED

Post-translational modifications for HAUS6 Gene

  • Phosphorylated during mitosis.
  • Ubiquitination at Lys199, Lys598, Lys694, Lys704, and Lys847
  • Modification sites at PhosphoSitePlus

Other Protein References for HAUS6 Gene

Antibody Products

No data available for DME Specific Peptides for HAUS6 Gene

Domains for HAUS6 Gene

Gene Families for HAUS6 Gene

HGNC:
  • HAUS :HAUS augmin-like complex subunits

Protein Domains for HAUS6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HAUS6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z4H7

UniProtKB/Swiss-Prot:

HAUS6_HUMAN :
  • Q7Z4H7
Family:
  • Belongs to the HAUS6 family.
genes like me logo Genes that share domains with HAUS6: view

Function for HAUS6 Gene

Molecular function for HAUS6 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin.

Gene Ontology (GO) - Molecular Function for HAUS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HAUS6: view

Phenotypes for HAUS6 Gene

GenomeRNAi human phenotypes for HAUS6:
genes like me logo Genes that share phenotypes with HAUS6: view

Animal Model Products

CRISPR Products

miRNA for HAUS6 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAUS6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HAUS6 Gene

Localization for HAUS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS6 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAUS6 Gene COMPARTMENTS Subcellular localization image for HAUS6 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HAUS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IDA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with HAUS6: view

Pathways for HAUS6 Gene

SuperPathways for HAUS6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HAUS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051225 spindle assembly IMP 19369198
GO:0051297 centrosome organization IMP 19427217
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with HAUS6: view

No data available for Pathways by source for HAUS6 Gene

Transcripts for HAUS6 Gene

Unigene Clusters for HAUS6 Gene

HAUS augmin-like complex, subunit 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAUS6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS6 Gene

No ASD Table

Relevant External Links for HAUS6 Gene

GeneLoc Exon Structure for
HAUS6
ECgene alternative splicing isoforms for
HAUS6

Expression for HAUS6 Gene

mRNA expression in normal human tissues for HAUS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for HAUS6 Gene

This gene is overexpressed in Testis (28.5), Heart (18.8), Ovary (8.9), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HAUS6 Gene

SOURCE GeneReport for Unigene cluster for HAUS6 Gene Hs.533468

genes like me logo Genes that share expressions with HAUS6: view

Expression partners for HAUS6 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HAUS6 Gene

Orthologs for HAUS6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HAUS6 35
  • 85.62 (n)
  • 75.45 (a)
HAUS6 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAUS6 35
  • 86.23 (n)
  • 77.18 (a)
HAUS6 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Haus6 35
  • 78.39 (n)
  • 65.8 (a)
Haus6 16
Haus6 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HAUS6 35
  • 99.23 (n)
  • 98.85 (a)
HAUS6 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HAUS6 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAUS6 36
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves HAUS6 35
  • 54.06 (n)
  • 36.84 (a)
HAUS6 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HAUS6 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia haus6 35
  • 52.72 (n)
  • 38.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9393 35
zebrafish
(Danio rerio)
Actinopterygii haus6 35
  • 46.84 (n)
  • 32.98 (a)
haus6 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6744 36
  • 20 (a)
OneToOne
Species with no ortholog for HAUS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS6 Gene

ENSEMBL:
Gene Tree for HAUS6 (if available)
TreeFam:
Gene Tree for HAUS6 (if available)

Paralogs for HAUS6 Gene

Pseudogenes.org Pseudogenes for HAUS6 Gene

genes like me logo Genes that share paralogs with HAUS6: view

No data available for Paralogs for HAUS6 Gene

Variants for HAUS6 Gene

Sequence variations from dbSNP and Humsavar for HAUS6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1048169 -- 19,055,967(-) ACTAA(A/G)TGGTT utr-variant-3-prime
rs2171954 -- 19,061,661(-) GTTGG(A/G)AACTC intron-variant
rs2171955 -- 19,061,660(-) TTGGG(A/G)ACTCA intron-variant
rs2171956 -- 19,061,640(-) CCAGG(C/T)TGGTC intron-variant
rs2171957 -- 19,086,981(-) CAATA(A/G)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAUS6 Gene

Variant ID Type Subtype PubMed ID
nsv892700 CNV Gain 21882294

Relevant External Links for HAUS6 Gene

HapMap Linkage Disequilibrium report
HAUS6
Human Gene Mutation Database (HGMD)
HAUS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAUS6 Gene

Disorders for HAUS6 Gene

Relevant External Links for HAUS6

Genetic Association Database (GAD)
HAUS6
Human Genome Epidemiology (HuGE) Navigator
HAUS6

No disorders were found for HAUS6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HAUS6 Gene

Publications for HAUS6 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4
  3. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R. … Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  5. Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. (PMID: 18443220) Goshima G. … Vale R.D. (J. Cell Biol. 2008) 3 4

Products for HAUS6 Gene

Sources for HAUS6 Gene

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