Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HAUS5 Gene

Aliases for HAUS5 Gene

  • HAUS Augmin Like Complex Subunit 5 2 3 5
  • KIAA0841 2 3 4
  • HAUS Augmin-Like Complex, Subunit 5 3
  • Dgt5 3

External Ids for HAUS5 Gene

Previous HGNC Symbols for HAUS5 Gene

  • KIAA0841

Previous GeneCards Identifiers for HAUS5 Gene

  • GC19P040797
  • GC19P036103
  • GC19P032608
  • GC19P035691
  • GC19P035816

Summaries for HAUS5 Gene

Entrez Gene Summary for HAUS5 Gene

  • HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

GeneCards Summary for HAUS5 Gene

HAUS5 (HAUS Augmin Like Complex Subunit 5) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for HAUS5 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS5 Gene

Genomics for HAUS5 Gene

Regulatory Elements for HAUS5 Gene

Promoters for HAUS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HAUS5 on UCSC Golden Path with GeneCards custom track

Genomic Location for HAUS5 Gene

Chromosome:
19
Start:
35,612,744 bp from pter
End:
35,625,349 bp from pter
Size:
12,606 bases
Orientation:
Plus strand

Genomic View for HAUS5 Gene

Genes around HAUS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAUS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAUS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS5 Gene

Proteins for HAUS5 Gene

  • Protein details for HAUS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94927-HAUS5_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 5
    Protein Accession:
    O94927
    Secondary Accessions:
    • B2RXK1
    • Q6P2P7
    • Q7L3D5
    • Q96CT8

    Protein attributes for HAUS5 Gene

    Size:
    633 amino acids
    Molecular mass:
    71682 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
    SequenceCaution:
    • Sequence=AAH13947.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA74864.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS5 Gene

Proteomics data for HAUS5 Gene at MOPED

Post-translational modifications for HAUS5 Gene

  • Ubiquitination at Lys 77, Lys 208, Lys 405, Lys 428, Lys 471, Lys 540, and Lys 630
  • Modification sites at PhosphoSitePlus

Other Protein References for HAUS5 Gene

No data available for DME Specific Peptides for HAUS5 Gene

Domains & Families for HAUS5 Gene

Gene Families for HAUS5 Gene

Protein Domains for HAUS5 Gene

Suggested Antigen Peptide Sequences for HAUS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94927

UniProtKB/Swiss-Prot:

HAUS5_HUMAN :
  • Belongs to the HAUS5 family.
Family:
  • Belongs to the HAUS5 family.
genes like me logo Genes that share domains with HAUS5: view

Function for HAUS5 Gene

Molecular function for HAUS5 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
genes like me logo Genes that share phenotypes with HAUS5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HAUS5 Gene

Localization for HAUS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS5 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269 PubMed:19369198, ECO:0000269 PubMed:19427217}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAUS5 Gene COMPARTMENTS Subcellular localization image for HAUS5 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for HAUS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0005819 spindle IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with HAUS5: view

Pathways & Interactions for HAUS5 Gene

genes like me logo Genes that share pathways with HAUS5: view

Gene Ontology (GO) - Biological Process for HAUS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with HAUS5: view

No data available for SIGNOR curated interactions for HAUS5 Gene

Drugs & Compounds for HAUS5 Gene

No Compound Related Data Available

Transcripts for HAUS5 Gene

Unigene Clusters for HAUS5 Gene

HAUS augmin-like complex, subunit 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS5 Gene

No ASD Table

Relevant External Links for HAUS5 Gene

GeneLoc Exon Structure for
HAUS5
ECgene alternative splicing isoforms for
HAUS5

Expression for HAUS5 Gene

mRNA expression in normal human tissues for HAUS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HAUS5 Gene

This gene is overexpressed in Liver, secretome (27.4), CD8 Tcells (12.9), and Blymphocyte (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HAUS5 Gene



SOURCE GeneReport for Unigene cluster for HAUS5 Gene Hs.7426

genes like me logo Genes that share expression patterns with HAUS5: view

Protein tissue co-expression partners for HAUS5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HAUS5 Gene

Orthologs for HAUS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HAUS5 35
  • 84.16 (n)
  • 79.58 (a)
HAUS5 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAUS5 35
  • 86.39 (n)
  • 82.59 (a)
HAUS5 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Haus5 35
  • 78.51 (n)
  • 73.02 (a)
Haus5 16
Haus5 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HAUS5 35
  • 97.79 (n)
  • 96.21 (a)
HAUS5 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Haus5 35
  • 79.86 (n)
  • 73.93 (a)
lizard
(Anolis carolinensis)
Reptilia HAUS5 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145714 35
  • 46.96 (n)
  • 34.85 (a)
zebrafish
(Danio rerio)
Actinopterygii haus5 35
  • 43.09 (n)
  • 29.26 (a)
haus5 36
  • 24 (a)
OneToOne
Species with no ortholog for HAUS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS5 Gene

ENSEMBL:
Gene Tree for HAUS5 (if available)
TreeFam:
Gene Tree for HAUS5 (if available)

Paralogs for HAUS5 Gene

No data available for Paralogs for HAUS5 Gene

Variants for HAUS5 Gene

Sequence variations from dbSNP and Humsavar for HAUS5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2301596 - 35,617,369(+) CCTCC(C/T)GTGAG nc-transcript-variant, reference, missense
rs2285412 - 35,618,410(+) CCAGG(A/C)CCCGG intron-variant, reference, missense
rs2285413 -- 35,622,557(+) CCAGC(A/G)AGCCA intron-variant
rs2285414 -- 35,622,756(+) CGCGG(A/G)TGGGA intron-variant, downstream-variant-500B
rs2301595 -- 35,613,192(+) AGTTA(A/G)CCGTG intron-variant, upstream-variant-2KB

Variation tolerance for HAUS5 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAUS5 Gene

HapMap Linkage Disequilibrium report
HAUS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HAUS5 Gene

Disorders for HAUS5 Gene

Relevant External Links for HAUS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAUS5

No disorders were found for HAUS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAUS5 Gene

Publications for HAUS5 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for HAUS5 Gene

Sources for HAUS5 Gene

Back to Top

Content