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Aliases for HAUS5 Gene

Aliases for HAUS5 Gene

  • HAUS Augmin-Like Complex, Subunit 5 2 3
  • KIAA0841 2 3 4 6
  • Dgt5 3 6
  • HAUS Augmin-Like Complex Subunit 5 3

External Ids for HAUS5 Gene

Previous HGNC Symbols for HAUS5 Gene

  • KIAA0841

Previous GeneCards Identifiers for HAUS5 Gene

  • GC19P040797
  • GC19P036103
  • GC19P032608

Summaries for HAUS5 Gene

Entrez Gene Summary for HAUS5 Gene

  • HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

GeneCards Summary for HAUS5 Gene

HAUS5 (HAUS Augmin-Like Complex, Subunit 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HAUS5 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS5 Gene

Genomics for HAUS5 Gene

Regulatory Elements for HAUS5 Gene

Genomic Location for HAUS5 Gene

Start:
35,612,744 bp from pter
End:
35,625,349 bp from pter
Size:
12,606 bases
Orientation:
Plus strand

Genomic View for HAUS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAUS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS5 Gene

Proteins for HAUS5 Gene

  • Protein details for HAUS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94927-HAUS5_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 5
    Protein Accession:
    O94927
    Secondary Accessions:
    • B2RXK1
    • Q6P2P7
    • Q7L3D5
    • Q96CT8

    Protein attributes for HAUS5 Gene

    Size:
    633 amino acids
    Molecular mass:
    71682 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
    SequenceCaution:
    • Sequence=AAH13947.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA74864.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS5 Gene

Proteomics data for HAUS5 Gene at MOPED

Post-translational modifications for HAUS5 Gene

  • Ubiquitination at Lys77, Lys208, Lys405, Lys428, Lys471, Lys540, and Lys630
  • Modification sites at PhosphoSitePlus

Other Protein References for HAUS5 Gene

No data available for DME Specific Peptides for HAUS5 Gene

Domains for HAUS5 Gene

Gene Families for HAUS5 Gene

HGNC:
  • HAUS :HAUS augmin-like complex subunits

Protein Domains for HAUS5 Gene

Suggested Antigen Peptide Sequences for HAUS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94927

UniProtKB/Swiss-Prot:

HAUS5_HUMAN :
  • O94927
Family:
  • Belongs to the HAUS5 family.
genes like me logo Genes that share domains with HAUS5: view

Function for HAUS5 Gene

Molecular function for HAUS5 Gene

UniProtKB/Swiss-Prot Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Ontology (GO) - Molecular Function for HAUS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HAUS5: view

Phenotypes for HAUS5 Gene

GenomeRNAi human phenotypes for HAUS5:
genes like me logo Genes that share phenotypes with HAUS5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HAUS5 Gene

Localization for HAUS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS5 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAUS5 Gene COMPARTMENTS Subcellular localization image for HAUS5 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for HAUS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005819 spindle IEA --
GO:0005874 microtubule IEA --
GO:0070652 HAUS complex IDA 19369198
genes like me logo Genes that share ontologies with HAUS5: view

Pathways for HAUS5 Gene

SuperPathways for HAUS5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HAUS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051225 spindle assembly IMP 19369198
GO:0051297 centrosome organization IMP 19427217
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with HAUS5: view

No data available for Pathways by source for HAUS5 Gene

Transcripts for HAUS5 Gene

Unigene Clusters for HAUS5 Gene

HAUS augmin-like complex, subunit 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAUS5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HAUS5
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS5 Gene

No ASD Table

Relevant External Links for HAUS5 Gene

GeneLoc Exon Structure for
HAUS5
ECgene alternative splicing isoforms for
HAUS5

Expression for HAUS5 Gene

mRNA expression in normal human tissues for HAUS5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HAUS5 Gene

SOURCE GeneReport for Unigene cluster for HAUS5 Gene Hs.7426

genes like me logo Genes that share expressions with HAUS5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HAUS5 Gene

Orthologs for HAUS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAUS5 35
  • 97.79 (n)
  • 96.21 (a)
HAUS5 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HAUS5 35
  • 84.16 (n)
  • 79.58 (a)
HAUS5 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAUS5 35
  • 86.39 (n)
  • 82.59 (a)
HAUS5 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Haus5 35
  • 78.51 (n)
  • 73.02 (a)
Haus5 16
Haus5 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Haus5 35
  • 79.86 (n)
  • 73.93 (a)
lizard
(Anolis carolinensis)
Reptilia HAUS5 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145714 35
  • 46.96 (n)
  • 34.85 (a)
zebrafish
(Danio rerio)
Actinopterygii haus5 35
  • 43.09 (n)
  • 29.26 (a)
haus5 36
  • 24 (a)
OneToOne
Species with no ortholog for HAUS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS5 Gene

ENSEMBL:
Gene Tree for HAUS5 (if available)
TreeFam:
Gene Tree for HAUS5 (if available)

Paralogs for HAUS5 Gene

No data available for Paralogs for HAUS5 Gene

Variants for HAUS5 Gene

Sequence variations from dbSNP and Humsavar for HAUS5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2285412 - 35,618,410(+) CCAGG(A/C)CCCGG missense, reference, intron-variant
rs2285413 -- 35,622,557(+) CCAGC(A/G)AGCCA intron-variant
rs2285414 -- 35,622,756(+) CGCGG(A/G)TGGGA intron-variant
rs2301595 -- 35,613,192(+) AGTTA(A/G)CCGTG intron-variant
rs2301596 - 35,617,369(+) CCTCC(C/T)GTGAG reference, missense, nc-transcript-variant

Relevant External Links for HAUS5 Gene

HapMap Linkage Disequilibrium report
HAUS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HAUS5 Gene

Disorders for HAUS5 Gene

No disorders were found for HAUS5 Gene.

No data available for UniProtKB/Swiss-Prot for HAUS5 Gene

Publications for HAUS5 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R. … Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  5. Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. (PMID: 18443220) Goshima G. … Vale R.D. (J. Cell Biol. 2008) 3

Products for HAUS5 Gene

Sources for HAUS5 Gene

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