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Aliases for HAUS5 Gene

Aliases for HAUS5 Gene

  • HAUS Augmin Like Complex Subunit 5 2 3 5
  • KIAA0841 2 3 4
  • HAUS Augmin-Like Complex Subunit 5 3
  • Dgt5 3

External Ids for HAUS5 Gene

Previous HGNC Symbols for HAUS5 Gene

  • KIAA0841

Previous GeneCards Identifiers for HAUS5 Gene

  • GC19P040797
  • GC19P036103
  • GC19P032608
  • GC19P035691
  • GC19P035816
  • GC19P035839
  • GC19P035996
  • GC19P036161
  • GC19P036232
  • GC19P036405

Summaries for HAUS5 Gene

Entrez Gene Summary for HAUS5 Gene

  • HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

GeneCards Summary for HAUS5 Gene

HAUS5 (HAUS Augmin Like Complex Subunit 5) is a Protein Coding gene. Diseases associated with HAUS5 include Joubert Syndrome 1. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition.

UniProtKB/Swiss-Prot for HAUS5 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Additional gene information for HAUS5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS5 Gene

Genomics for HAUS5 Gene

GeneHancer (GH) Regulatory Elements for HAUS5 Gene

Promoters and enhancers for HAUS5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I035612 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 588.6 +0.1 63 1.5 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 E2F8 ZNF207 HAUS5 ENSG00000267626 ZNF599 ZNF529 ZNF302 ZNF566 ZNF260 ZNF181 TMEM147-AS1 ZFP82
GH19I034994 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 103.2 -611.8 -611812 13.5 CLOCK MLX YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF548 GRAMD1A ENSG00000269303 TMEM147-AS1 ZNF599 HAUS5 LSM14A KMT2B ZNF792 KIAA0355 ZNF302
GH19I035946 Enhancer 1.5 FANTOM5 Ensembl ENCODE 160.2 +334.6 334649 0.8 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 ZNF213 ZNF302 E2F8 LOC105372383 ZNF567 ZNF345 TMEM147-AS1 ZNF850 HAUS5 PROSER3 ZNF790 KMT2B ZNF529
GH19I035461 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 118.7 -149.8 -149793 1.9 HDGF PKNOX1 SMAD1 ZNF493 ZFP64 IRF4 ZNF121 ZNF213 ATF7 KLF7 TMEM147-AS1 HAUS5 ZNF599 KMT2B PROSER3 RBM42 ZFP82 ZNF146 ZNF792 ZNF302
GH19I035266 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 82.7 -344.3 -344283 4.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B ZNF766 USF2 ZNF599 HAUS5 TMEM147-AS1 KMT2B PROSER3 ZNF146 ZNF792 ZNF565 RBM42
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HAUS5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HAUS5 gene promoter:

Genomic Locations for HAUS5 Gene

Genomic Locations for HAUS5 Gene
chr19:35,612,744-35,625,349
(GRCh38/hg38)
Size:
12,606 bases
Orientation:
Plus strand
chr19:36,103,646-36,116,251
(GRCh37/hg19)

Genomic View for HAUS5 Gene

Genes around HAUS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAUS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAUS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS5 Gene

Proteins for HAUS5 Gene

  • Protein details for HAUS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94927-HAUS5_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 5
    Protein Accession:
    O94927
    Secondary Accessions:
    • B2RXK1
    • Q6P2P7
    • Q7L3D5
    • Q96CT8

    Protein attributes for HAUS5 Gene

    Size:
    633 amino acids
    Molecular mass:
    71682 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
    SequenceCaution:
    • Sequence=AAH13947.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA74864.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS5 Gene

Post-translational modifications for HAUS5 Gene

  • Ubiquitination at posLast=7777, posLast=208208, posLast=405405, isoforms=428, isoforms=471, isoforms=540, and posLast=630630

Other Protein References for HAUS5 Gene

No data available for DME Specific Peptides for HAUS5 Gene

Domains & Families for HAUS5 Gene

Gene Families for HAUS5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HAUS5 Gene

Suggested Antigen Peptide Sequences for HAUS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94927

UniProtKB/Swiss-Prot:

HAUS5_HUMAN :
  • Belongs to the HAUS5 family.
Family:
  • Belongs to the HAUS5 family.
genes like me logo Genes that share domains with HAUS5: view

Function for HAUS5 Gene

Molecular function for HAUS5 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Phenotypes From GWAS Catalog for HAUS5 Gene

Gene Ontology (GO) - Molecular Function for HAUS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 19369198
genes like me logo Genes that share ontologies with HAUS5: view
genes like me logo Genes that share phenotypes with HAUS5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HAUS5 Gene

Localization for HAUS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS5 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269 PubMed:19369198, ECO:0000269 PubMed:19427217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAUS5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for HAUS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HAUS5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HAUS5 Gene

Pathways & Interactions for HAUS5 Gene

genes like me logo Genes that share pathways with HAUS5: view

Gene Ontology (GO) - Biological Process for HAUS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007098 centrosome cycle IMP,IEA 19427217
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0051225 spindle assembly IMP,IEA 19369198
genes like me logo Genes that share ontologies with HAUS5: view

No data available for SIGNOR curated interactions for HAUS5 Gene

Drugs & Compounds for HAUS5 Gene

No Compound Related Data Available

Transcripts for HAUS5 Gene

Unigene Clusters for HAUS5 Gene

HAUS augmin-like complex, subunit 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS5 Gene

No ASD Table

Relevant External Links for HAUS5 Gene

GeneLoc Exon Structure for
HAUS5
ECgene alternative splicing isoforms for
HAUS5

Expression for HAUS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HAUS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HAUS5 Gene

This gene is overexpressed in Liver, secretome (27.4), CD8 Tcells (12.9), and Blymphocyte (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HAUS5 Gene



Protein tissue co-expression partners for HAUS5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HAUS5 Gene:

HAUS5

SOURCE GeneReport for Unigene cluster for HAUS5 Gene:

Hs.7426

Evidence on tissue expression from TISSUES for HAUS5 Gene

  • Nervous system(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with HAUS5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAUS5 Gene

Orthologs for HAUS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAUS5 33 34
  • 97.79 (n)
dog
(Canis familiaris)
Mammalia HAUS5 33 34
  • 86.39 (n)
cow
(Bos Taurus)
Mammalia HAUS5 33 34
  • 84.16 (n)
rat
(Rattus norvegicus)
Mammalia Haus5 33
  • 79.86 (n)
mouse
(Mus musculus)
Mammalia Haus5 33 16 34
  • 78.51 (n)
lizard
(Anolis carolinensis)
Reptilia HAUS5 34
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145714 33
  • 46.96 (n)
zebrafish
(Danio rerio)
Actinopterygii haus5 33 34
  • 43.09 (n)
Species where no ortholog for HAUS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS5 Gene

ENSEMBL:
Gene Tree for HAUS5 (if available)
TreeFam:
Gene Tree for HAUS5 (if available)

Paralogs for HAUS5 Gene

No data available for Paralogs for HAUS5 Gene

Variants for HAUS5 Gene

Sequence variations from dbSNP and Humsavar for HAUS5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000060718 -- 35,616,478(+) C/T intron_variant
rs1000080171 -- 35,610,820(+) C/G upstream_transcript_variant
rs1000195038 -- 35,610,954(+) G/A upstream_transcript_variant
rs1000822204 -- 35,613,065(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001376111 -- 35,613,459(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Variation tolerance for HAUS5 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HAUS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAUS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HAUS5 Gene

Disorders for HAUS5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HAUS5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
joubert syndrome 1
  • jbts1
- elite association - COSMIC cancer census association via MalaCards
Search HAUS5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HAUS5

genes like me logo Genes that share disorders with HAUS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HAUS5 Gene

Publications for HAUS5 Gene

  1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S … Pelletier L (Current biology : CB 2009) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R … Goshima G (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for HAUS5 Gene

Sources for HAUS5 Gene

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