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Aliases for HAUS4 Gene

Aliases for HAUS4 Gene

  • HAUS Augmin Like Complex Subunit 4 2 3 5
  • C14orf94 3 4
  • Chromosome 14 Open Reading Frame 94 2
  • HAUS Augmin-Like Complex, Subunit 4 3
  • Homologous To Augmin Subunits 3

External Ids for HAUS4 Gene

Previous HGNC Symbols for HAUS4 Gene

  • C14orf94

Previous GeneCards Identifiers for HAUS4 Gene

  • GC14M022486
  • GC14M023415
  • GC14M003533

Summaries for HAUS4 Gene

Entrez Gene Summary for HAUS4 Gene

  • This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

GeneCards Summary for HAUS4 Gene

HAUS4 (HAUS Augmin Like Complex Subunit 4) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. An important paralog of this gene is ENSG00000259132.

UniProtKB/Swiss-Prot for HAUS4 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS4 Gene

Genomics for HAUS4 Gene

Regulatory Elements for HAUS4 Gene

Enhancers for HAUS4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HAUS4 on UCSC Golden Path with GeneCards custom track

Promoters for HAUS4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HAUS4 on UCSC Golden Path with GeneCards custom track

Genomic Location for HAUS4 Gene

Chromosome:
14
Start:
22,946,228 bp from pter
End:
22,957,161 bp from pter
Size:
10,934 bases
Orientation:
Minus strand

Genomic View for HAUS4 Gene

Genes around HAUS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAUS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAUS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS4 Gene

Proteins for HAUS4 Gene

  • Protein details for HAUS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6D7-HAUS4_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 4
    Protein Accession:
    Q9H6D7
    Secondary Accessions:
    • B7WP17
    • D3DS34
    • Q86T15
    • Q86T16
    • Q86U43
    • Q9NX59

    Protein attributes for HAUS4 Gene

    Size:
    363 amino acids
    Molecular mass:
    42400 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
    SequenceCaution:
    • Sequence=CAD62584.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS4 Gene

Proteomics data for HAUS4 Gene at MOPED

Post-translational modifications for HAUS4 Gene

  • Ubiquitination at Lys 201 and Lys 360
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HAUS4 Gene

Domains & Families for HAUS4 Gene

Gene Families for HAUS4 Gene

Protein Domains for HAUS4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HAUS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6D7

UniProtKB/Swiss-Prot:

HAUS4_HUMAN :
  • Belongs to the HAUS4 family.
Family:
  • Belongs to the HAUS4 family.
genes like me logo Genes that share domains with HAUS4: view

Function for HAUS4 Gene

Molecular function for HAUS4 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
genes like me logo Genes that share phenotypes with HAUS4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAUS4 Gene

Localization for HAUS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269 PubMed:19369198, ECO:0000269 PubMed:19427217}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAUS4 Gene COMPARTMENTS Subcellular localization image for HAUS4 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HAUS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0005819 spindle IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with HAUS4: view

Pathways & Interactions for HAUS4 Gene

genes like me logo Genes that share pathways with HAUS4: view

Gene Ontology (GO) - Biological Process for HAUS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with HAUS4: view

No data available for SIGNOR curated interactions for HAUS4 Gene

Drugs & Compounds for HAUS4 Gene

No Compound Related Data Available

Transcripts for HAUS4 Gene

Unigene Clusters for HAUS4 Gene

HAUS augmin-like complex, subunit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - -
SP9: - -
SP10: - - - - - -
SP11:
SP12: - - - - - -

Relevant External Links for HAUS4 Gene

GeneLoc Exon Structure for
HAUS4
ECgene alternative splicing isoforms for
HAUS4

Expression for HAUS4 Gene

mRNA expression in normal human tissues for HAUS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAUS4 Gene

This gene is overexpressed in Whole Blood (x8.0).

Protein differential expression in normal tissues from HIPED for HAUS4 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (57.9) and Breast (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HAUS4 Gene



SOURCE GeneReport for Unigene cluster for HAUS4 Gene Hs.442782

genes like me logo Genes that share expression patterns with HAUS4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HAUS4 Gene

Orthologs for HAUS4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HAUS4 35
  • 88.61 (n)
  • 87.6 (a)
-- 36
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Haus4 35
  • 81.63 (n)
  • 78.24 (a)
Haus4 16
Haus4 36
  • 78 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia HAUS4 35
  • 99.63 (n)
  • 99.17 (a)
HAUS4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Haus4 35
  • 83.1 (n)
  • 81.27 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia haus4 35
  • 55.2 (n)
  • 45.59 (a)
zebrafish
(Danio rerio)
Actinopterygii haus4 35
  • 49.14 (n)
  • 35.14 (a)
haus4 36
  • 32 (a)
OneToMany
Species with no ortholog for HAUS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS4 Gene

ENSEMBL:
Gene Tree for HAUS4 (if available)
TreeFam:
Gene Tree for HAUS4 (if available)

Paralogs for HAUS4 Gene

Paralogs for HAUS4 Gene

Pseudogenes.org Pseudogenes for HAUS4 Gene

genes like me logo Genes that share paralogs with HAUS4: view

Variants for HAUS4 Gene

Sequence variations from dbSNP and Humsavar for HAUS4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs712486 -- 22,955,832(-) ATTAC(A/G)CCTTT intron-variant
rs3794455 -- 22,959,104(+) CGAGA(C/T)GATCC upstream-variant-2KB
rs76445593 -- 22,959,120(+) TCTAC(A/C)AAAAA upstream-variant-2KB
rs139194515 -- 22,956,445(+) CGCAC(A/T)TGGAA intron-variant
rs77008863 -- 22,959,129(+) AAAAA(A/T)TACAA upstream-variant-2KB

Variation tolerance for HAUS4 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for HAUS4 Gene

Disorders for HAUS4 Gene

Relevant External Links for HAUS4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAUS4

No disorders were found for HAUS4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAUS4 Gene

Publications for HAUS4 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for HAUS4 Gene

Sources for HAUS4 Gene

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