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Aliases for HAUS4 Gene

Aliases for HAUS4 Gene

  • HAUS Augmin-Like Complex, Subunit 4 2 3
  • C14orf94 3 4 6
  • Chromosome 14 Open Reading Frame 94 2
  • HAUS Augmin-Like Complex Subunit 4 3
  • Homologous To Augmin Subunits 3

External Ids for HAUS4 Gene

Previous Symbols for HAUS4 Gene

  • C14orf94

Summaries for HAUS4 Gene

Entrez Gene Summary for HAUS4 Gene

  • This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

GeneCards Summary for HAUS4 Gene

HAUS4 (HAUS Augmin-Like Complex, Subunit 4) is a Protein Coding gene. An important paralog of this gene is ENSG00000259132.

UniProtKB/Swiss-Prot for HAUS4 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS4 Gene

Genomics for HAUS4 Gene

Genomic Location for HAUS4 Gene

Start:
22,946,228 bp from pter
End:
22,957,161 bp from pter
Size:
10,934 bases
Orientation:
Minus strand

Genomic View for HAUS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAUS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS4 Gene

Regulatory Elements for HAUS4 Gene

Proteins for HAUS4 Gene

  • Protein details for HAUS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6D7-HAUS4_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 4
    Protein Accession:
    Q9H6D7
    Secondary Accessions:
    • B7WP17
    • D3DS34
    • Q86T15
    • Q86T16
    • Q86U43
    • Q9NX59

    Protein attributes for HAUS4 Gene

    Size:
    363 amino acids
    Molecular mass:
    42400 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
    SequenceCaution:
    • Sequence=CAD62584.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS4 Gene

Proteomics data for HAUS4 Gene at MOPED

Post-translational modifications for HAUS4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys201 and Lys360

No data available for DME Specific Peptides for HAUS4 Gene

Domains for HAUS4 Gene

Gene Families for HAUS4 Gene

HGNC:
  • HAUS :HAUS augmin-like complex subunits

Protein Domains for HAUS4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

HAUS4_HUMAN
Family:
  • Belongs to the HAUS4 family.:
    • Q9H6D7
genes like me logo Genes that share domains with HAUS4: view

Function for HAUS4 Gene

Molecular function for HAUS4 Gene

UniProtKB/Swiss-Prot Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Ontology (GO) - Molecular Function for HAUS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HAUS4: view

Phenotypes for HAUS4 Gene

genes like me logo Genes that share phenotypes with HAUS4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HAUS4 Gene

Localization for HAUS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAUS4 Gene COMPARTMENTS Subcellular localization image for HAUS4 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HAUS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005819 spindle IEA --
GO:0005874 microtubule IEA --
GO:0070652 HAUS complex IDA 19369198
genes like me logo Genes that share ontologies with HAUS4: view

Pathways for HAUS4 Gene

SuperPathways for HAUS4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HAUS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051225 spindle assembly IMP 19369198
GO:0051297 centrosome organization IMP 19427217
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with HAUS4: view

No data available for Pathways by source for HAUS4 Gene

Transcripts for HAUS4 Gene

Unigene Clusters for HAUS4 Gene

HAUS augmin-like complex, subunit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - -
SP9: - -
SP10: - - - - - -
SP11:
SP12: - - - - - -

Relevant External Links for HAUS4 Gene

GeneLoc Exon Structure for
HAUS4
ECgene alternative splicing isoforms for
HAUS4

Expression for HAUS4 Gene

mRNA expression in normal human tissues for HAUS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAUS4 Gene

This gene is overexpressed in Whole Blood (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HAUS4 Gene

SOURCE GeneReport for Unigene cluster for HAUS4 Gene Hs.442782

genes like me logo Genes that share expressions with HAUS4: view

Orthologs for HAUS4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAUS4 36
  • 99.63 (n)
  • 99.17 (a)
HAUS4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 88 (a)
OneToMany
HAUS4 36
  • 88.61 (n)
  • 87.6 (a)
mouse
(Mus musculus)
Mammalia Haus4 36
  • 81.63 (n)
  • 78.24 (a)
Haus4 16
Haus4 37
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Haus4 36
  • 83.1 (n)
  • 81.27 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia haus4 36
  • 55.2 (n)
  • 45.59 (a)
zebrafish
(Danio rerio)
Actinopterygii haus4 36
  • 49.14 (n)
  • 35.14 (a)
haus4 37
  • 32 (a)
OneToMany
Species with no ortholog for HAUS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS4 Gene

ENSEMBL:
Gene Tree for HAUS4 (if available)
TreeFam:
Gene Tree for HAUS4 (if available)

Paralogs for HAUS4 Gene

Paralogs for HAUS4 Gene

Pseudogenes.org Pseudogenes for HAUS4 Gene

genes like me logo Genes that share paralogs with HAUS4: view

Variants for HAUS4 Gene

Sequence variations from dbSNP and Humsavar for HAUS4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs712486 -- 22,955,832(-) ATTAC(A/G)CCTTT intron-variant
rs3794455 -- 22,959,104(+) CGAGA(C/T)GATCC upstream-variant-2KB
rs61060692 -- 22,955,677(+) TTTTT(-/T)ATCAT intron-variant
rs74407611 -- 22,955,678(+) TTTTT(A/T)TCATT intron-variant
rs76445593 -- 22,959,120(+) TCTAC(A/C)AAAAA upstream-variant-2KB

Relevant External Links for HAUS4 Gene

HapMap Linkage Disequilibrium report
HAUS4

No data available for Structural Variations from Database of Genomic Variants (DGV) for HAUS4 Gene

Disorders for HAUS4 Gene

No disorders were found for HAUS4 Gene.

No data available for UniProtKB/Swiss-Prot for HAUS4 Gene

Publications for HAUS4 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R. … Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for HAUS4 Gene

Sources for HAUS4 Gene

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