HAUS3 Gene
protein-coding GIFtS: 41
GCID: GC04M002199
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HAUS augmin-like complex, subunit 3(Previous name: chromosome 4 open reading frame 15 )
(Previous symbol: C4orf15)
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Aliases
for HAUS3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HAUS Augmin-Like Complex, Subunit 31 2 | | MGC47011 | | C4orf151 2 3 5 | | Chromosome 4 Open Reading Frame 151 | | IT11 2 | | HAUS Augmin-Like Complex Subunit 32 | | Dgt31 | | DGT35 |
Export aliases for HAUS3 gene to outside databases |
Summaries
for HAUS3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HAUS3:
HAUS3 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identifiedin Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is amicrotubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitoticspindle assembly (Goshima et al., 2008 (PubMed 18443220); Uehara et al., 2009 (PubMed 19369198)).(supplied by OMIM,Nov 2010)
UniProtKB/Swiss-Prot: HAUS3_HUMAN, Q68CZ6Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis aspart of the HAUS augmin-like complex
Gene Wiki entry for HAUS3
|
Genomic Views
for HAUS3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006051.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HAUS3 gene promoter:
E2F-3a E2F-4 E2F-5 MIF-1 E2F-2 AREB6 FAC1 E2F-1 E2F TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for HAUS3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAUS3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3HAUS3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M002199: view genomic region
(about GC identifiers)
Start:
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2,229,191 bp from pter |
End:
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2,243,891 bp from pter |
Size:
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14,701 bases |
Orientation:
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minus strand |
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Proteins
for HAUS3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HAUS3_HUMAN, Q68CZ6 (See
protein sequence)Recommended Name: HAUS augmin-like complex subunit 3 Size: 603 amino acids; 69650 Da
Subunit: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and thisinteraction is required for spindle assembly
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes tointerphase centrosomes and to mitotic spindle microtubules
Sequence caution: Sequence=AAB97010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAH03648.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH03648.1;Type=Frameshift; Positions=12; Sequence=AAH25356.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O43606 Q8TAZ5 Q9BTJ9Explore the universe of human proteins at neXtProt for HAUS3: NX_Q68CZ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q68CZ6
HAUS3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078787.2
ENSEMBL proteins: ENSP00000427350 ENSP00000243706 ENSP00000392903 ENSP00000423285 ENSP00000427356
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
HAUS3 for ontologies About GeneDecksing
HAUS3 Antibody Products:
Assay Products for HAUS3: |
Protein
Domains /
Families
for HAUS3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HAUS3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q68CZ6ProtoNet protein and cluster: Q68CZ6 UniProtKB/Swiss-Prot: HAUS3_HUMAN, Q68CZ6Similarity: Belongs to the HAUS3 family |
Function
for HAUS3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HAUS3_HUMAN, Q68CZ6Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis aspart of the HAUS augmin-like complex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HAUS3 (NM_024511) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HAUS3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAUS3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003674 | molecular_function |
ND | -- |
HAUS3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HAUS3:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Haus3):
HAUS3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HAUS3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HAUS3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for HAUS3 (Q68CZ63 ENSP000002437064) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
HAUS3 for ontologies About GeneDecksing
|
Drugs & Compounds
for HAUS3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HAUS3
Search CenterWatch for drugs/clinical trials and news about HAUS3
|
Transcripts
for HAUS3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HAUS3 gene: NM_024511.5 Unigene Cluster for HAUS3: HAUS augmin-like complex, subunit 3 Hs.665869 [show with all ESTs]Unigene Representative Sequence: CR7496405 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000506763(uc011bvj.1) ENST00000243706(uc003ges.1 uc003get.1)
ENST00000443786 ENST00000514395 ENST00000502440
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HAUS3 (NM_024511) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HAUS3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAUS3 |
Additional cDNA sequence: AF040964.1 AK056134.1 AK293948.1 BC003648.2 BC025356.1 CR749640.1 6 DOTS entries: DT.211673 DT.95154834 DT.91638687 DT.75188831 DT.100675141 DT.121236946 24/71 AceView cDNA sequences (see all 71): AY136549 BX400052 AK056134 AW169985 CA865481 AI627212 CR749640 CA421871 AW513701 AF040964 AI628516 AL709166 BG678161 AA442824 BQ024208 BC025356 BC003648 AI674093 NM_181808 BM843545 NM_024511 BX114515 AA630380 AV646359
GeneLoc Exon Structure
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Expression
for HAUS3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HAUS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTGTGATA
About this image
See HAUS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HAUS3
SOURCE GeneReport for Unigene cluster: Hs.665869
SABiosciences Custom PCR Arrays for HAUS3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAUS3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HAUS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAUS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAUS3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS3 |
Orthologs
for HAUS3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HAUS3 gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for HAUS3 (if available)
TreeFam Gene Tree for HAUS3 (if available) |
Paralogs
for HAUS3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HAUS3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for HAUS3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 HAUS3 for disorders About MalaCards
HAUS3 for disorders About GeneDecksing
OMIM gene information: 613430
OMIM disorders: --
Export disorders for HAUS3 gene to outside databases
|
Publications
for HAUS3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HAUS3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with HAUS3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PubMed id 19427217)1, 2, 3 Lawo S....Pelletier L. (2009)
- The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PubMed id 19369198)1, 2 Uehara R....Goshima G. (2009)
- Mutational evolution in a lobular breast tumour profi led at single nucleotide resolution. (PubMed id 19812674)1, 3 Shah S.P....Aparicio S. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. (PubMed id 18443220)1 Goshima G.... Vale R.D. (2008)
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External Searches for HAUS3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing HAUS3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HAUS3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HAUS3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HAUS3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HAUS3 gene:
Search GeneIP for patents involving HAUS3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HAUS3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HAUS3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAUS3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAUS3 | | | OriGene Protein Over-expression Lysate for HAUS3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HAUS3 | | OriGene 3'-UTR Clone for HAUS3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAUS3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HAUS3 | | OriGene Custom Protein Services for HAUS3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HAUS3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HAUS3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAUS3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAUS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAUS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAUS3 |
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| | | | Search Tocris compounds for HAUS3 |
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 | | | HAUS3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS3 |
|  |  |  | | | | Search ThermoFisher Antibodies for HAUS3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAUS3 |
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