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Aliases for HAUS3 Gene

Aliases for HAUS3 Gene

  • HAUS Augmin-Like Complex, Subunit 3 2 3
  • C4orf15 3 4 6
  • Dgt3 3 6
  • Chromosome 4 Open Reading Frame 15 2
  • HAUS Augmin-Like Complex Subunit 3 3
  • IT1 3

External Ids for HAUS3 Gene

Previous HGNC Symbols for HAUS3 Gene

  • C4orf15

Previous GeneCards Identifiers for HAUS3 Gene

  • GC04M002199

Summaries for HAUS3 Gene

Entrez Gene Summary for HAUS3 Gene

  • This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for HAUS3 Gene

HAUS3 (HAUS Augmin-Like Complex, Subunit 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HAUS3 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Wiki entry for HAUS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS3 Gene

Genomics for HAUS3 Gene

Regulatory Elements for HAUS3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HAUS3 Gene

Start:
2,227,464 bp from pter
End:
2,242,164 bp from pter
Size:
14,701 bases
Orientation:
Minus strand

Genomic View for HAUS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAUS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS3 Gene

Proteins for HAUS3 Gene

  • Protein details for HAUS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CZ6-HAUS3_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 3
    Protein Accession:
    Q68CZ6
    Secondary Accessions:
    • B4DF64
    • O43606
    • Q8TAZ5
    • Q9BTJ9

    Protein attributes for HAUS3 Gene

    Size:
    603 amino acids
    Molecular mass:
    69650 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
    SequenceCaution:
    • Sequence=AAB97010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH03648.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH03648.1; Type=Frameshift; Positions=12; Evidence={ECO:0000305}; Sequence=AAH25356.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS3 Gene

Proteomics data for HAUS3 Gene at MOPED

Post-translational modifications for HAUS3 Gene

  • Ubiquitination at Lys379, Lys444, and Lys564
  • Modification sites at PhosphoSitePlus

Other Protein References for HAUS3 Gene

No data available for DME Specific Peptides for HAUS3 Gene

Domains for HAUS3 Gene

Gene Families for HAUS3 Gene

HGNC:
  • HAUS :HAUS augmin-like complex subunits

Protein Domains for HAUS3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HAUS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q68CZ6

UniProtKB/Swiss-Prot:

HAUS3_HUMAN :
  • Q68CZ6
Family:
  • Belongs to the HAUS3 family.
genes like me logo Genes that share domains with HAUS3: view

Function for HAUS3 Gene

Molecular function for HAUS3 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Ontology (GO) - Molecular Function for HAUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HAUS3: view

Phenotypes for HAUS3 Gene

MGI mutant phenotypes for HAUS3:
inferred from 1 alleles
GenomeRNAi human phenotypes for HAUS3:
genes like me logo Genes that share phenotypes with HAUS3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HAUS3 Gene

Localization for HAUS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS3 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAUS3 Gene COMPARTMENTS Subcellular localization image for HAUS3 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HAUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005819 spindle IEA --
GO:0005874 microtubule IEA --
GO:0070652 HAUS complex IDA 19369198
genes like me logo Genes that share ontologies with HAUS3: view

Pathways for HAUS3 Gene

SuperPathways for HAUS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HAUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051225 spindle assembly IMP 19369198
GO:0051297 centrosome organization IMP 19427217
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with HAUS3: view

No data available for Pathways by source for HAUS3 Gene

Transcripts for HAUS3 Gene

Unigene Clusters for HAUS3 Gene

HAUS augmin-like complex, subunit 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAUS3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS3 Gene

No ASD Table

Relevant External Links for HAUS3 Gene

GeneLoc Exon Structure for
HAUS3
ECgene alternative splicing isoforms for
HAUS3

Expression for HAUS3 Gene

mRNA expression in normal human tissues for HAUS3 Gene

Protein differential expression in normal tissues for HAUS3 Gene

This gene is overexpressed in Plasma (47.6) and Heart (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HAUS3 Gene

SOURCE GeneReport for Unigene cluster for HAUS3 Gene Hs.665869

genes like me logo Genes that share expressions with HAUS3: view

Expression partners for HAUS3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HAUS3 Gene

Orthologs for HAUS3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HAUS3 35
  • 89.3 (n)
  • 86.36 (a)
HAUS3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAUS3 35
  • 89.76 (n)
  • 86.54 (a)
HAUS3 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Haus3 35
  • 84.44 (n)
  • 78.07 (a)
Haus3 16
Haus3 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Haus3 35
  • 83.53 (n)
  • 78.77 (a)
oppossum
(Monodelphis domestica)
Mammalia HAUS3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAUS3 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HAUS3 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves HAUS3 35
  • 65.33 (n)
  • 54.09 (a)
HAUS3 36
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486659 35
  • 56.91 (n)
  • 50.52 (a)
Str.18624 35
zebrafish
(Danio rerio)
Actinopterygii haus3 35
  • 46.93 (n)
  • 37.2 (a)
Species with no ortholog for HAUS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS3 Gene

ENSEMBL:
Gene Tree for HAUS3 (if available)
TreeFam:
Gene Tree for HAUS3 (if available)

Paralogs for HAUS3 Gene

No data available for Paralogs for HAUS3 Gene

Variants for HAUS3 Gene

Sequence variations from dbSNP and Humsavar for HAUS3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1179 -- 2,233,963(+) AATGA(C/T)CCTAT intron-variant
rs3774 -- 2,233,829(+) GGCGT(C/G)CATAN intron-variant
rs2031728 -- 2,232,125(-) TCTCA(A/G)CTGAA reference, synonymous-codon
rs2213312 -- 2,237,196(-) ACAAT(A/G)CTGGG intron-variant
rs2227021 -- 2,236,880(-) ataat(A/T)attat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAUS3 Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV Deletion 23290073
nsv520780 CNV Gain 19592680
nsv829838 CNV Loss 17160897
nsv878423 CNV Loss 21882294
nsv878424 CNV Loss 21882294
dgv5421n71 CNV Loss 21882294
dgv5422n71 CNV Loss 21882294

Relevant External Links for HAUS3 Gene

HapMap Linkage Disequilibrium report
HAUS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAUS3 Gene

Disorders for HAUS3 Gene

No disorders were found for HAUS3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HAUS3 Gene

Publications for HAUS3 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4
  2. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. (PMID: 19812674) Shah S.P. … Aparicio S. (Nature 2009) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R. … Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for HAUS3 Gene

Sources for HAUS3 Gene

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