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Aliases for HAUS3 Gene

Aliases for HAUS3 Gene

  • HAUS Augmin Like Complex Subunit 3 2 3 5
  • C4orf15 3 4
  • Chromosome 4 Open Reading Frame 15 2
  • HAUS Augmin-Like Complex Subunit 3 3
  • Dgt3 3
  • IT1 3

External Ids for HAUS3 Gene

Previous HGNC Symbols for HAUS3 Gene

  • C4orf15

Previous GeneCards Identifiers for HAUS3 Gene

  • GC04M002199

Summaries for HAUS3 Gene

Entrez Gene Summary for HAUS3 Gene

  • This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for HAUS3 Gene

HAUS3 (HAUS Augmin Like Complex Subunit 3) is a Protein Coding gene. Diseases associated with HAUS3 include Hypotrichosis 1 and Hair Disease. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for HAUS3 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Wiki entry for HAUS3 Gene

Additional gene information for HAUS3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS3 Gene

Genomics for HAUS3 Gene

Regulatory Elements for HAUS3 Gene

Enhancers for HAUS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H002489 1.3 Ensembl ENCODE dbSUPER 39.7 -247.9 -247943 1 BACH1 ZNF175 CEBPG ZNF766 GATA3 ZNF600 ZNF584 TRIM24 ZNF197 E2F5 RNF4 HAUS3 NELFA FAM193A ENSG00000270195 LOC105374353 ZFYVE28 ENSG00000251148 MXD4 POLN
GH04H002243 1.4 Ensembl ENCODE dbSUPER 36.1 -1.7 -1738 1 HDGF ARNT YBX1 NFXL1 ZNF2 RAD21 ZEB1 GLIS2 EGR1 ZNF366 HAUS3 RNF4 NELFA CRIPAK FAM193A NOP14 ENSG00000270195 MAEA MFSD10 ENSG00000254094
GH04H002255 1.3 ENCODE dbSUPER 35.3 -17.2 -17158 8 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 YY1 GTF3C2 GLIS2 HAUS3 RNF4 CRIPAK FAM193A NOP14 NELFA MAEA ADD1 ENSG00000254094 MXD4
GH04H002329 1.2 Ensembl ENCODE 35.7 -88.1 -88115 1 HDGF ARNT ZNF133 FEZF1 ZNF2 GLIS2 ZNF416 FOS SP3 YY2 NELFA RNF4 CRIPAK HAUS3 FAM193A NOP14 ENSG00000270195 MFSD10 ENSG00000254094 ENSG00000207009
GH04H001867 1.7 FANTOM5 ENCODE dbSUPER 25 +371.0 370975 7 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 HAUS3 RNF4 NELFA CRIPAK GAK FAM193A CTBP1-AS2 MAEA ENSG00000270195 NSD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HAUS3 on UCSC Golden Path with GeneCards custom track

Promoters for HAUS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164930 364 2001 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 ETS1 SLC30A9

Genomic Location for HAUS3 Gene

Chromosome:
4
Start:
2,227,464 bp from pter
End:
2,242,164 bp from pter
Size:
14,701 bases
Orientation:
Minus strand

Genomic View for HAUS3 Gene

Genes around HAUS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAUS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAUS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS3 Gene

Proteins for HAUS3 Gene

  • Protein details for HAUS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CZ6-HAUS3_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 3
    Protein Accession:
    Q68CZ6
    Secondary Accessions:
    • B4DF64
    • O43606
    • Q8TAZ5
    • Q9BTJ9

    Protein attributes for HAUS3 Gene

    Size:
    603 amino acids
    Molecular mass:
    69650 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
    SequenceCaution:
    • Sequence=AAB97010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH03648.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH03648.1; Type=Frameshift; Positions=12; Evidence={ECO:0000305}; Sequence=AAH25356.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS3 Gene

Post-translational modifications for HAUS3 Gene

  • Ubiquitination at isoforms=2379, isoforms=2444, and isoforms=564
  • Modification sites at PhosphoSitePlus

Other Protein References for HAUS3 Gene

No data available for DME Specific Peptides for HAUS3 Gene

Domains & Families for HAUS3 Gene

Gene Families for HAUS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HAUS3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HAUS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q68CZ6

UniProtKB/Swiss-Prot:

HAUS3_HUMAN :
  • Belongs to the HAUS3 family.
Family:
  • Belongs to the HAUS3 family.
genes like me logo Genes that share domains with HAUS3: view

Function for HAUS3 Gene

Molecular function for HAUS3 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Phenotypes From GWAS Catalog for HAUS3 Gene

Gene Ontology (GO) - Molecular Function for HAUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HAUS3: view
genes like me logo Genes that share phenotypes with HAUS3: view

Animal Model Products

CRISPR Products

miRNA for HAUS3 Gene

miRTarBase miRNAs that target HAUS3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HAUS3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HAUS3 Gene

Localization for HAUS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS3 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269 PubMed:19427217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAUS3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 4
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (3)
  • Mitochondria (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HAUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with HAUS3: view

Pathways & Interactions for HAUS3 Gene

genes like me logo Genes that share pathways with HAUS3: view

Gene Ontology (GO) - Biological Process for HAUS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007098 centrosome cycle IMP 19427217
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0051225 spindle assembly IMP,IEA 19369198
genes like me logo Genes that share ontologies with HAUS3: view

No data available for SIGNOR curated interactions for HAUS3 Gene

Drugs & Compounds for HAUS3 Gene

No Compound Related Data Available

Transcripts for HAUS3 Gene

Unigene Clusters for HAUS3 Gene

HAUS augmin-like complex, subunit 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HAUS3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS3 Gene

No ASD Table

Relevant External Links for HAUS3 Gene

GeneLoc Exon Structure for
HAUS3
ECgene alternative splicing isoforms for
HAUS3

Expression for HAUS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HAUS3 Gene

Protein differential expression in normal tissues from HIPED for HAUS3 Gene

This gene is overexpressed in Plasma (47.6) and Heart (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HAUS3 Gene



Protein tissue co-expression partners for HAUS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HAUS3 Gene:

HAUS3

SOURCE GeneReport for Unigene cluster for HAUS3 Gene:

Hs.665869

Evidence on tissue expression from TISSUES for HAUS3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with HAUS3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAUS3 Gene

Orthologs for HAUS3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAUS3 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAUS3 33 34
  • 89.76 (n)
cow
(Bos Taurus)
Mammalia HAUS3 33 34
  • 89.3 (n)
mouse
(Mus musculus)
Mammalia Haus3 33 16 34
  • 84.44 (n)
rat
(Rattus norvegicus)
Mammalia Haus3 33
  • 83.53 (n)
oppossum
(Monodelphis domestica)
Mammalia HAUS3 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAUS3 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves HAUS3 33 34
  • 65.33 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
OneToMany
-- 34
  • 46 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486659 33
  • 56.91 (n)
Str.18624 33
zebrafish
(Danio rerio)
Actinopterygii haus3 33
  • 46.93 (n)
Species where no ortholog for HAUS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS3 Gene

ENSEMBL:
Gene Tree for HAUS3 (if available)
TreeFam:
Gene Tree for HAUS3 (if available)

Paralogs for HAUS3 Gene

No data available for Paralogs for HAUS3 Gene

Variants for HAUS3 Gene

Sequence variations from dbSNP and Humsavar for HAUS3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000123561 -- 2,232,671(+) GAATT(-/AC)ACATG intron-variant
rs1000495893 -- 2,232,861(+) TCACC(-/AA)AGAGG intron-variant
rs1000991345 -- 2,242,658(+) CGACC(A/C)ATGCC upstream-variant-2KB
rs1001277229 -- 2,243,724(+) GCCTG(A/G)TGGGA upstream-variant-2KB
rs1001320293 -- 2,242,425(+) GAGGG(A/G)TGCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HAUS3 Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV deletion 23290073
nsv1009347 CNV gain 25217958
nsv520780 CNV gain 19592680
nsv829838 CNV loss 17160897

Variation tolerance for HAUS3 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.99; 68.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAUS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAUS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAUS3 Gene

Disorders for HAUS3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HAUS3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypotrichosis 1
  • hereditary generalized hypotrichosis simplex
hair disease
  • abnormality of the hair
- elite association - COSMIC cancer census association via MalaCards
Search HAUS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HAUS3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAUS3
genes like me logo Genes that share disorders with HAUS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HAUS3 Gene

Publications for HAUS3 Gene

  1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S … Pelletier L (Current biology : CB 2009) 2 3 4 60
  2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R … Goshima G (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 60
  3. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. (PMID: 19812674) Shah SP … Aparicio S (Nature 2009) 2 3 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for HAUS3 Gene

Sources for HAUS3 Gene

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