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Aliases for HAUS2 Gene

Aliases for HAUS2 Gene

  • HAUS Augmin-Like Complex, Subunit 2 2 3
  • Centrosomal Protein Of 27 KDa 3 4
  • Centrosomal Protein 27kDa 2 3
  • C15orf25 3 4
  • CEP27 3 4
  • Chromosome 15 Open Reading Frame 25 2
  • HsT17025 3

External Ids for HAUS2 Gene

Previous HGNC Symbols for HAUS2 Gene

  • C15orf25
  • CEP27

Previous GeneCards Identifiers for HAUS2 Gene

  • GC15P040630
  • GC15P042841
  • GC15P019688

Summaries for HAUS2 Gene

Entrez Gene Summary for HAUS2 Gene

  • HAUS2 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

GeneCards Summary for HAUS2 Gene

HAUS2 (HAUS Augmin-Like Complex, Subunit 2) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for HAUS2 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS2 Gene

Genomics for HAUS2 Gene

Regulatory Elements for HAUS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HAUS2 Gene

Chromosome:
15
Start:
42,548,810 bp from pter
End:
42,569,994 bp from pter
Size:
21,185 bases
Orientation:
Plus strand

Genomic View for HAUS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAUS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS2 Gene

Proteins for HAUS2 Gene

  • Protein details for HAUS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVX0-HAUS2_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 2
    Protein Accession:
    Q9NVX0
    Secondary Accessions:
    • C9JH36
    • Q9H9B3

    Protein attributes for HAUS2 Gene

    Size:
    235 amino acids
    Molecular mass:
    26933 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.

    Alternative splice isoforms for HAUS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS2 Gene

Proteomics data for HAUS2 Gene at MOPED

Post-translational modifications for HAUS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for HAUS2 Gene

Domains & Families for HAUS2 Gene

Gene Families for HAUS2 Gene

Protein Domains for HAUS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HAUS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVX0

UniProtKB/Swiss-Prot:

HAUS2_HUMAN :
  • Belongs to the HAUS2 family.
Family:
  • Belongs to the HAUS2 family.
genes like me logo Genes that share domains with HAUS2: view

Function for HAUS2 Gene

Molecular function for HAUS2 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Ontology (GO) - Molecular Function for HAUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HAUS2: view
genes like me logo Genes that share phenotypes with HAUS2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HAUS2 Gene

Localization for HAUS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAUS2 Gene COMPARTMENTS Subcellular localization image for HAUS2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
golgi apparatus 4
nucleus 4

Gene Ontology (GO) - Cellular Components for HAUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005813 centrosome IDA 14654843
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HAUS2: view

Pathways & Interactions for HAUS2 Gene

genes like me logo Genes that share pathways with HAUS2: view

Gene Ontology (GO) - Biological Process for HAUS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0031023 microtubule organizing center organization --
genes like me logo Genes that share ontologies with HAUS2: view

No data available for SIGNOR curated interactions for HAUS2 Gene

Drugs & Compounds for HAUS2 Gene

No Compound Related Data Available

Transcripts for HAUS2 Gene

Unigene Clusters for HAUS2 Gene

HAUS augmin-like complex, subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -

Relevant External Links for HAUS2 Gene

GeneLoc Exon Structure for
HAUS2
ECgene alternative splicing isoforms for
HAUS2

Expression for HAUS2 Gene

mRNA expression in normal human tissues for HAUS2 Gene

Protein differential expression in normal tissues from HIPED for HAUS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (52.0), Fetal ovary (6.6), and CD8 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HAUS2 Gene



SOURCE GeneReport for Unigene cluster for HAUS2 Gene Hs.14347

genes like me logo Genes that share expression patterns with HAUS2: view

Protein tissue co-expression partners for HAUS2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HAUS2 Gene

Orthologs for HAUS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HAUS2 35
  • 89.65 (n)
  • 85.53 (a)
CEP27 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAUS2 35
  • 88.94 (n)
  • 85.53 (a)
HAUS2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Haus2 35
  • 81.34 (n)
  • 70.51 (a)
Haus2 16
Haus2 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HAUS2 35
  • 100 (n)
  • 100 (a)
HAUS2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Haus2 35
  • 81.62 (n)
  • 70.94 (a)
oppossum
(Monodelphis domestica)
Mammalia HAUS2 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAUS2 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves HAUS2 35
  • 61.71 (n)
  • 50.26 (a)
HAUS2 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HAUS2 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia haus2 35
  • 57.07 (n)
  • 54.15 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-170l10.1 35
  • 49.21 (n)
  • 37.57 (a)
HAUS2 36
  • 30 (a)
OneToOne
Species with no ortholog for HAUS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS2 Gene

ENSEMBL:
Gene Tree for HAUS2 (if available)
TreeFam:
Gene Tree for HAUS2 (if available)

Paralogs for HAUS2 Gene

No data available for Paralogs for HAUS2 Gene

Variants for HAUS2 Gene

Sequence variations from dbSNP and Humsavar for HAUS2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs10546541 -- 42,557,514(+) TATAT(-/TA)TATAT intron-variant
rs10710908 -- 42,568,016(+) AAAAA(-/A)GGTGT utr-variant-3-prime
rs10851410 -- 42,552,590(+) GGGCT(A/G)TCTGT intron-variant
rs11434263 -- 42,553,479(+) TTTTC(-/T/TT)TTTTT intron-variant
rs11630681 -- 42,557,233(+) atggc(A/G)tgaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAUS2 Gene

Variant ID Type Subtype PubMed ID
nsv528725 CNV Gain 19592680
esv2677430 CNV Deletion 23128226
nsv513429 CNV Insertion 21212237
esv1090131 CNV Insertion 17803354
esv2749624 CNV Deletion 23290073

Variation tolerance for HAUS2 Gene

Residual Variation Intolerance Score: 66.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAUS2 Gene

HapMap Linkage Disequilibrium report
HAUS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAUS2 Gene

Disorders for HAUS2 Gene

Relevant External Links for HAUS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAUS2
genes like me logo Genes that share disorders with HAUS2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAUS2 Gene

Publications for HAUS2 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 67
  3. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 67

Products for HAUS2 Gene

Sources for HAUS2 Gene

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