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HAUS2 Gene

protein-coding   GIFtS: 51
GCID: GC15P042841

HAUS Augmin-Like Complex, Subunit 2

(Previous names: chromosome 15 open reading frame 25, centrosomal protein...)
(Previous symbols: C15orf25, CEP27)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HAUS Augmin-Like Complex, Subunit 21 2     Chromosome 15 Open Reading Frame 251
CEP271 2 3 5     HsT170252
C15orf251 2 3     HAUS Augmin-Like Complex Subunit 22
Centrosomal Protein 27kDa1 2     Cep273
Centrosomal Protein Of 27 KDa2 3     

External Ids:    HGNC: 255301   Entrez Gene: 551422   Ensembl: ENSG000001378147   OMIM: 6134295   UniProtKB: Q9NVX03   

Export aliases for HAUS2 gene to outside databases

Previous GC identifers: GC15P040630 GC15P019688


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAUS2 Gene:
HAUS2 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first
identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin
complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is
vital to mitotic spindle assembly (Goshima et al., 2008 (PubMed 18443220); Uehara et al., 2009 (PubMed
19369198)).(supplied by OMIM, Jun 2010)

GeneCards Summary for HAUS2 Gene:
HAUS2 (HAUS augmin-like complex, subunit 2) is a protein-coding gene. Diseases associated with HAUS2 include congenital dyserythropoietic anemia type i, and congenital dyserythropoietic anemia.

UniProtKB/Swiss-Prot: HAUS2_HUMAN, Q9NVX0
Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of
cytokinesis as part of the HAUS augmin-like complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAUS2 gene promoter:
         c-Fos   AP-1   JunB   Bach2   Fra-1   FosB   CUTL1   HNF-4alpha1   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAUS2 promoter sequence
   Search Chromatin IP Primers for HAUS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAUS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.2   Ensembl cytogenetic band:  15q15.2   HGNC cytogenetic band: 15q15.1

HAUS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAUS2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P042841:  view genomic region     (about GC identifiers)

Start:
42,841,008 bp from pter      End:
42,862,192 bp from pter
Size:
21,185 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HAUS2_HUMAN, Q9NVX0 (See protein sequence)
Recommended Name: HAUS augmin-like complex subunit 2  
Size: 235 amino acids; 26933 Da
Subunit: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and
this interaction is required for spindle assembly
Secondary accessions: C9JH36 Q9H9B3
Alternative splicing: 3 isoforms:  Q9NVX0-1   Q9NVX0-2   Q9NVX0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HAUS2: NX_Q9NVX0

Explore proteomics data for HAUS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HAUS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123919.1  NP_060567.1  

    ENSEMBL proteins: 
     ENSP00000260372   ENSP00000457169   ENSP00000456578   ENSP00000475743   ENSP00000455942  
     ENSP00000456054   ENSP00000390445   ENSP00000455104   ENSP00000455118   ENSP00000475909  
    Reactome Protein details: Q9NVX0

    HAUS2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    HAUS2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HAUS: HAUS augmin-like complex subunits

    2 InterPro protein domains:
     IPR028346 HAUS2
     IPR026242 HAUS2_metazoa

    Graphical View of Domain Structure for InterPro Entry Q9NVX0

    ProtoNet protein and cluster: Q9NVX0

    UniProtKB/Swiss-Prot: HAUS2_HUMAN, Q9NVX0
    Similarity: Belongs to the HAUS2 family


    HAUS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HAUS2_HUMAN, Q9NVX0
    Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of
    cytokinesis as part of the HAUS augmin-like complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    HAUS2 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for HAUS2:
     Cell cycle / mitosis defect  Decreased TP53 protein express  G0/1 arrest  Increased G1 DNA content 
     Increased cell number in G2M,   Increased gamma-H2AX phosphory  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAUS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HAUS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAUS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAUS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HAUS2:
    hsa-mir-20a-5p (MIRT050510)

    Block miRNA regulation of human, mouse, rat HAUS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HAUS2 (see all 16):
    hsa-miR-3200-5p hsa-miR-16-2* hsa-miR-4328 hsa-miR-16-1* hsa-miR-520a-5p hsa-miR-10b* hsa-miR-133a hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidHAUS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HAUS2
    Predesigned siRNA for gene silencing in human, mouse, rat HAUS2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for HAUS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HAUS2 (NM_018097)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAUS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAUS2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HAUS2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HAUS2_HUMAN, Q9NVX0: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
    spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    golgi apparatus4
    nucleus4
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005813centrosome IDA--

    HAUS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HAUS2 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for HAUS2
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    Loss of Nlp from mitotic centrosomes



    HAUS2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HAUS2
    Interactions:

        Search GeneGlobe Interaction Network for HAUS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HAUS2 (Q9NVX02, 3 ENSP000002603724) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FXYD6Q9H0Q32, 3MINT-65446 I2D: score=5 
    MAPK6Q166592, 3MINT-8260867 I2D: score=2 
    HAUS6Q7Z4H73, ENSP000003698714I2D: score=1 STRING: ENSP00000369871
    HAUS1Q96CS23, ENSP000002820584I2D: score=1 STRING: ENSP00000282058
    HAUS3Q68CZ63, ENSP000002437064I2D: score=1 STRING: ENSP00000243706
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0051225spindle assembly IMP19369198
    GO:0051297centrosome organization IMP19427217

    HAUS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HAUS2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HAUS2 gene (2 alternative transcripts): 
    NM_001130447.1  NM_018097.2  

    Unigene Cluster for HAUS2:

    HAUS augmin-like complex, subunit 2
    Hs.14347  [show with all ESTs]
    Unigene Representative Sequence: NM_018097
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260372(uc001zqe.3 uc010udi.2 uc001zqf.3) ENST00000567640
    ENST00000568876 ENST00000568846 ENST00000562398 ENST00000563479 ENST00000391623
    ENST00000564279 ENST00000570178 ENST00000607467
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HAUS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HAUS2 (see all 16):
    hsa-miR-3200-5p hsa-miR-16-2* hsa-miR-4328 hsa-miR-16-1* hsa-miR-520a-5p hsa-miR-10b* hsa-miR-133a hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidHAUS2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HAUS2
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    OriGene clones in human, mouse for HAUS2 (see all 12)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HAUS2 (NM_018097)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAUS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAUS2
    Primer
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    OriGene qPCR primer pairs and template standards for HAUS2
    OriGene qSTAR qPCR primer pairs in human, mouse for HAUS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAUS2
      QuantiTect SYBR Green Assays in human, mouse, rat HAUS2
      QuantiFast Probe-based Assays in human, mouse, rat HAUS2

    Additional mRNA sequence: 

    AK001322.1 AK022939.1 BC010903.1 

    9 DOTS entries:

    DT.410597  DT.310193  DT.100754231  DT.92421719  DT.121063244  DT.70100694  DT.95100321  DT.91743091 
    DT.95121472 

    Selected AceView cDNA sequences (see all 86):

    NM_018097 AI918737 AA278755 BU182237 AK001322 AI368236 BG676263 C17470 
    BM833913 AI870316 AA039303 BG480433 AW663420 BG754253 BG716931 AI241489 
    AW167803 BG398223 AI248305 BG473190 BX364007 AA830507 AA278916 BX472954 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HAUS2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
    SP1:                                -     -           -                           
    SP2:                    -           -     -           -                           
    SP3:                                -     -     -     -                           
    SP4:                    -                                                         
    SP5:                                                  -                           


    ECgene alternative splicing isoforms for HAUS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HAUS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAAAGCC
    HAUS2 Expression
    About this image


    HAUS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    HAUS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HAUS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.14347
        Custom PCR Arrays for HAUS2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HAUS2
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    QuantiFast Probe-based Assays in human, mouse, rat HAUS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HAUS2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Haus21 , 5 HAUS augmin-like complex, subunit 21, 5 81.34(n)1
    70.51(a)1
      2 (60.37 cM)5
    662961  NM_025475.21  NP_079751.11 
     1206093835 
    chicken
    (Gallus gallus)
    Aves HAUS21 HAUS augmin-like complex, subunit 2 61.71(n)
    50.26(a)
      423237  NM_001199667.1  NP_001186596.1 
    lizard
    (Anolis carolinensis)
    Reptilia HAUS26
    HAUS augmin-like complex, subunit 2
    46(a)
    1 ↔ 1
    1(39826857-39838242)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia haus21 HAUS augmin-like complex, subunit 2 57.07(n)
    54.15(a)
      548581  NM_001015864.1  NP_001015864.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-170l10.11 si:dkey-170l10.1 49.21(n)
    37.57(a)
      567090  NM_001201430.1  NP_001188359.1 


    ENSEMBL Gene Tree for HAUS2 (if available)
    TreeFam Gene Tree for HAUS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HAUS2 (see all 448)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925340571,2
    --42843059(+) ATGGGC/GTTTCA 2 -- int10--------
    rs80331371,2
    C,A--42843107(+) tgatcC/Tgcctg 2 -- int16Minor allele frequency- T:0.00NA WA 12
    rs1129270861,2
    C,F--42843154(+) GCCACC/TGCACC 2 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs563715731,2
    C--42843195(+) TTTTTT/-CTGAG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1504599411,2
    --42843311(+) GCTCCC/TGAGTA 2 -- int10--------
    rs1843384851,2
    --42843374(+) AGAGAC/TGGGGT 2 -- int10--------
    rs1896202371,2
    --42843469(+) CCCAGC/GCTTTT 2 -- int10--------
    rs1379720041,2
    --42843487(+) ATCAGA/GTTACC 2 -- int10--------
    rs1930574271,2
    --42843494(+) TACCTA/CGTACT 2 -- int10--------
    rs1857744761,2
    --42843515(+) TTGTCC/TAGTTC 2 -- int10--------

    HapMap Linkage Disequilibrium report for HAUS2 (42841008 - 42862192 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HAUS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749624CNV Deletion23290073
    esv2677430CNV Deletion23128226
    esv1090131CNV Insertion17803354
    nsv513429CNV Insertion21212237
    nsv528725CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613429    OMIM disorders: --

    6 diseases for HAUS2:    
    About MalaCards
    congenital dyserythropoietic anemia type i    congenital dyserythropoietic anemia    tonsillitis    cerebritis
    thyroiditis    prostatitis


    HAUS2 for disorders           About GeneDecksing


    Export disorders for HAUS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HAUS2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with HAUS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PubMed id 19427217)1, 2, 3 Lawo S....Pelletier L. (Curr. Biol. 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)1, 2, 3 Andersen J.S....Mann M. (Nature 2003)
    4. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PubMed id 19369198)1, 2 Uehara R....Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55142 HGNC: 25530 AceView: C15orf25 Ensembl:ENSG00000137814 euGenes: HUgn55142
    ECgene: HAUS2 H-InvDB: HAUS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HAUS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HAUS2 gene:
    Search GeneIP for patents involving HAUS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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