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HAUS1 Gene

protein-coding   GIFtS: 50
GCID: GC18P043684

HAUS Augmin-Like Complex, Subunit 1

(Previous name: coiled-coil domain containing 5 (spindle associated))
(Previous symbol: CCDC5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HAUS Augmin-Like Complex, Subunit 11 2     Enhancer Of Invasion-Cluster2 3
CCDC51 2 3 5     HEI-C2 3
HEIC2 3 5     HsT14612
Coiled-Coil Domain Containing 5 (Spindle Associated)1 2     HAUS Augmin-Like Complex Subunit 12
Coiled-Coil Domain-Containing Protein 52 3     

External Ids:    HGNC: 251741   Entrez Gene: 1151062   Ensembl: ENSG000001522407   OMIM: 6087755   UniProtKB: Q96CS23   

Export aliases for HAUS1 gene to outside databases

Previous GC identifers: GC18P041940 GC18P040541


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAUS1 Gene:
HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first
identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin
complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is
vital to mitotic spindle assembly (Goshima et al., 2008 (PubMed 18443220); Uehara et al., 2009 (PubMed
19369198)).(supplied by OMIM, Jun 2010)

GeneCards Summary for HAUS1 Gene:
HAUS1 (HAUS augmin-like complex, subunit 1) is a protein-coding gene. Diseases associated with HAUS1 include newcastle disease, and cholera.

UniProtKB/Swiss-Prot: HAUS1_HUMAN, Q96CS2
Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of
cytokinesis as part of the HAUS augmin-like complex

Gene Wiki entry for HAUS1 (CCDC5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAUS1 gene promoter:
         Spz1   AML1a   CUTL1   NF-kappaB   POU3F2   N-Myc   Egr-2   CREB   deltaCREB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAUS1 promoter sequence
   Search Chromatin IP Primers for HAUS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAUS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

HAUS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAUS1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P043684:  view genomic region     (about GC identifiers)

Start:
43,684,298 bp from pter      End:
43,708,299 bp from pter
Size:
24,002 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HAUS1_HUMAN, Q96CS2 (See protein sequence)
Recommended Name: HAUS augmin-like complex subunit 1  
Size: 278 amino acids; 31863 Da
Subunit: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and
this interaction is required for spindle assembly. Associates with microtubules. The interaction with
microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this
interaction is direct or indirect
Miscellaneous: HAUS1-depleted cells retain functional cell cycle checkpoints, but the depletion decreases the G2/M
cell cycle compartment and induces apoptosis. The protein level remains constant through the cell cycle
Sequence caution: Sequence=BAC05036.1; Type=Frameshift; Positions=15;
Secondary accessions: B2RDM7 Q8N837
Alternative splicing: 2 isoforms:  Q96CS2-1   Q96CS2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HAUS1: NX_Q96CS2

Explore proteomics data for HAUS1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys17, Lys197, Lys223, Lys237
  • Modification sites at PhosphoSitePlus

  • See HAUS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612452.1  
    ENSEMBL proteins: 
     ENSP00000282058   ENSP00000468575   ENSP00000466364   ENSP00000465093   ENSP00000465492  
     ENSP00000467975   ENSP00000466715   ENSP00000465622  

    HAUS1 Human Recombinant Protein Products:

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    HAUS1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HAUS: HAUS augmin-like complex subunits

    1 InterPro protein domain:
     IPR026243 HAUS1

    Graphical View of Domain Structure for InterPro Entry Q96CS2

    ProtoNet protein and cluster: Q96CS2

    UniProtKB/Swiss-Prot: HAUS1_HUMAN, Q96CS2
    Similarity: Belongs to the HAUS1 family


    HAUS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HAUS1_HUMAN, Q96CS2
    Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of
    cytokinesis as part of the HAUS augmin-like complex

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
         
    HAUS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HAUS1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAUS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HAUS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAUS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAUS1

    miRNA
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    miRTarBase miRNAs that target HAUS1:
    hsa-mir-92a-3p (MIRT049760)

    Block miRNA regulation of human, mouse, rat HAUS1 using miScript Target Protectors
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    GenScript: all cDNA clones in your preferred vector: HAUS1 (NM_138443)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HAUS1_HUMAN, Q96CS2: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
    cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes with the spindle poles in mitotic
    cells. In metaphase, localizes to the mitotic asters and is highly punctate on the microtubule array. During
    later stages of mitosis, remains on the spindle but is not present at the interzone, and is finally observed at
    the microtubule bundles proximal to the midbody, clearly excluded from the midbody. In contrast, does not
    colocalize with the tubulin cytoskeleton in interphase cells. In interphase, localized at the centrosome and
    diffusely in the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--
    GO:0005874microtubule IEA--
    GO:0070652HAUS complex IDA19369198

    HAUS1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HAUS1
    Interactions:

        Search GeneGlobe Interaction Network for HAUS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for HAUS1 (Q96CS21, 2, 3 ENSP000002820584) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ORC1Q134152, 3, ENSP000003606214MINT-50396 I2D: score=1 STRING: ENSP00000360621
    MCM10Q7L5902, 3MINT-50393 I2D: score=2 
    CDKN2AP427712, 3MINT-50398 I2D: score=1 
    CDT1Q9H2112, 3, ENSP000003010194MINT-50422 I2D: score=1 STRING: ENSP00000301019
    MCM3P252052, 3, ENSP000002298544MINT-50394 I2D: score=2 STRING: ENSP00000229854
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0051225spindle assembly IMP19369198
    GO:0051297centrosome organization IMP19427217

    HAUS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HAUS1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HAUS1 gene: 
    NM_138443.3  

    Unigene Cluster for HAUS1:

    HAUS augmin-like complex, subunit 1
    Hs.436617  [show with all ESTs]
    Unigene Representative Sequence: BM799713
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282058(uc002lbv.3 uc002lbu.3) ENST00000592471 ENST00000591098
    ENST00000586060 ENST00000591715 ENST00000592206 ENST00000585518 ENST00000589554
    ENST00000593165 ENST00000588704 ENST00000595199 ENST00000585425
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HAUS1
      QuantiFast Probe-based Assays in human, mouse, rat HAUS1

    Additional mRNA sequence: 

    AK024747.1 AK097403.1 AK315605.1 AY360137.1 BC005958.1 BC014003.2 NR_026978.1 

    15 DOTS entries:

    DT.447650  DT.100703034  DT.100032516  DT.95274939  DT.121095212  DT.92433881  DT.92433867  DT.100037166 
    DT.121095097  DT.100846667  DT.121095197  DT.121095315  DT.120809073  DT.92433879  DT.216234 

    Selected AceView cDNA sequences (see all 230):

    CR599261 BQ434707 BM564766 AA461018 AK097403 BC005958 AY360137 BU193260 
    AV715391 AA150718 AA361156 BQ946246 CD514777 BX370184 BQ716050 BU195631 
    AI221810 CR601181 BQ575128 BM758655 AA524489 BX370185 BM452026 BM474058 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HAUS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGAACTGT
    HAUS1 Expression
    About this image


    HAUS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    HAUS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HAUS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436617

    UniProtKB/Swiss-Prot: HAUS1_HUMAN, Q96CS2
    Tissue specificity: Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver and heart. Weakly
    expressed in lung, brain and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAUS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HAUS1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Haus11 , 5 HAUS augmin-like complex, subunit 11, 5 83.93(n)1
    84.17(a)1
      18 (52.38 cM)5
    2257451  NM_146089.21  NP_666201.11 
     777575675 
    chicken
    (Gallus gallus)
    Aves HAUS11 HAUS augmin-like complex, subunit 1 61.92(n)
    50.73(a)
      416380  NM_001030625.1  NP_001025796.1 
    lizard
    (Anolis carolinensis)
    Reptilia HAUS16
    HAUS augmin-like complex, subunit 1
    52(a)
    1 ↔ 1
    1(35066209-35083721)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia haus11 HAUS augmin-like complex, subunit 1 59.98(n)
    56.57(a)
      100127614  NM_001112969.1  NP_001106440.1 
    zebrafish
    (Danio rerio)
    Actinopterygii haus11 HAUS augmin-like complex, subunit 1 51.78(n)
    42.44(a)
      553389  NM_001256249.1  NP_001243178.1 


    ENSEMBL Gene Tree for HAUS1 (if available)
    TreeFam Gene Tree for HAUS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HAUS1 gene
    14 SIMAP similar genes for HAUS1 using alignment to 7 protein entries:     HAUS1_HUMAN (see all proteins):
    UTY    FAM3A    NSRP1    UBIAD1    ZNF564    DNAPTP3
    DNMT1    ZNF738    NRAMP1    ZNF74    USP10    ZNF212
    ZNF547    PLEKHH2

    HAUS1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for HAUS1
    PGOHUM00000235776 PGOHUM00000249386 PGOHUM00000241659


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HAUS1 (see all 545)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340439901,2
    C--40549926(-) ATGGA-/ATATATA 2 -- int11Minor allele frequency- AT:0.00NA 2
    rs573072971,2
    C--43669411(+) TTTTT-/T/TT  
            
    GAGAC
    2 -- int11NA 2
    rs1474176741,2
    --43686315(+) CTGTAG/TTTCCA 2 -- int10--------
    rs118729541,2
    C,F,H--43686450(+) AAAGAA/GAAAAA 2 -- int1 trp36Minor allele frequency- G:0.27NA WA 246
    rs1914196611,2
    --43686462(+) AAAAAA/GTGCAT 2 -- int10--------
    rs1827391151,2
    --43686473(+) TCAAGA/TTGCCT 2 -- int10--------
    rs118729851,2
    C,F,H--43686578(+) GCCCTA/GTATTT 2 -- int16Minor allele frequency- G:0.20NA WA EA 364
    rs1390893321,2
    C--43686749(+) GCCAAA/GGTGGG 2 -- int10--------
    rs1870719771,2
    --43686840(+) GCCAGC/GTGTGG 2 -- int10--------
    rs1498947791,2
    --43686886(+) TGAGGA/CGGGAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for HAUS1 (43684298 - 43708299 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HAUS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv595e199CNV Deletion23128226
    esv2668326CNV Deletion23128226
    esv1334297CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HAUS1
    DNA2.0 Custom Variant and Variant Library Synthesis for HAUS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608775    OMIM disorders: --

    2 diseases for HAUS1:    
    About MalaCards
    newcastle disease    cholera


    HAUS1 for disorders           About GeneDecksing


    Export disorders for HAUS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HAUS1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with HAUS1)
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    1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PubMed id 19427217)1, 2, 3 Lawo S....Pelletier L. (Curr. Biol. 2009)
    2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PubMed id 19369198)1, 2 Uehara R....Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    3. Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis. (PubMed id 15082789)1, 2 Einarson M.B.... Golemis E.A. (Mol. Cell. Biol. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PubMed id 23793025)1 Anttila V.... . (Nat. Genet. 2013)
    7. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115106 HGNC: 25174 AceView: CCDC5 Ensembl:ENSG00000152240 euGenes: HUgn115106
    ECgene: HAUS1 H-InvDB: HAUS1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HAUS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HAUS1 gene:
    Search GeneIP for patents involving HAUS1

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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