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Aliases for HAUS1 Gene

Aliases for HAUS1 Gene

  • HAUS Augmin-Like Complex, Subunit 1 2 3
  • CCDC5 3 4 6
  • HEIC 3 4 6
  • Coiled-Coil Domain Containing 5 (Spindle Associated) 2 3
  • Coiled-Coil Domain-Containing Protein 5 3 4
  • Enhancer Of Invasion-Cluster 3 4
  • HEI-C 3 4
  • HAUS Augmin-Like Complex Subunit 1 3
  • HsT1461 3

External Ids for HAUS1 Gene

Previous HGNC Symbols for HAUS1 Gene

  • CCDC5

Previous GeneCards Identifiers for HAUS1 Gene

  • GC18P041940
  • GC18P043684
  • GC18P040541

Summaries for HAUS1 Gene

Entrez Gene Summary for HAUS1 Gene

  • HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

GeneCards Summary for HAUS1 Gene

HAUS1 (HAUS Augmin-Like Complex, Subunit 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HAUS1 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Wiki entry for HAUS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAUS1 Gene

Genomics for HAUS1 Gene

Regulatory Elements for HAUS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HAUS1 Gene

Start:
46,104,332 bp from pter
End:
46,128,333 bp from pter
Size:
24,002 bases
Orientation:
Plus strand

Genomic View for HAUS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAUS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAUS1 Gene

Proteins for HAUS1 Gene

  • Protein details for HAUS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CS2-HAUS1_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 1
    Protein Accession:
    Q96CS2
    Secondary Accessions:
    • B2RDM7
    • Q8N837

    Protein attributes for HAUS1 Gene

    Size:
    278 amino acids
    Molecular mass:
    31863 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect.
    Miscellaneous:
    • HAUS1-depleted cells retain functional cell cycle checkpoints, but the depletion decreases the G2/M cell cycle compartment and induces apoptosis. The protein level remains constant through the cell cycle
    SequenceCaution:
    • Sequence=BAC05036.1; Type=Frameshift; Positions=15; Evidence={ECO:0000305};

    Alternative splice isoforms for HAUS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAUS1 Gene

Proteomics data for HAUS1 Gene at MOPED

Post-translational modifications for HAUS1 Gene

  • Ubiquitination at Lys17, Lys197, Lys223, and Lys237
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HAUS1 Gene

Domains for HAUS1 Gene

Gene Families for HAUS1 Gene

HGNC:
  • HAUS :HAUS augmin-like complex subunits

Protein Domains for HAUS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HAUS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CS2

UniProtKB/Swiss-Prot:

HAUS1_HUMAN :
  • Q96CS2
Family:
  • Belongs to the HAUS1 family.
genes like me logo Genes that share domains with HAUS1: view

Function for HAUS1 Gene

Molecular function for HAUS1 Gene

UniProtKB/Swiss-Prot Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Ontology (GO) - Molecular Function for HAUS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with HAUS1: view

Phenotypes for HAUS1 Gene

GenomeRNAi human phenotypes for HAUS1:
genes like me logo Genes that share phenotypes with HAUS1: view

Animal Model Products

CRISPR Products

miRNA for HAUS1 Gene

miRTarBase miRNAs that target HAUS1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAUS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HAUS1 Gene

Localization for HAUS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAUS1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes with the spindle poles in mitotic cells. In metaphase, localizes to the mitotic asters and is highly punctate on the microtubule array. During later stages of mitosis, remains on the spindle but is not present at the interzone, and is finally observed at the microtubule bundles proximal to the midbody, clearly excluded from the midbody. In contrast, does not colocalize with the tubulin cytoskeleton in interphase cells. In interphase, localized at the centrosome and diffusely in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAUS1 Gene COMPARTMENTS Subcellular localization image for HAUS1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HAUS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005874 microtubule IEA --
GO:0070652 HAUS complex IDA 19369198
genes like me logo Genes that share ontologies with HAUS1: view

Pathways for HAUS1 Gene

SuperPathways for HAUS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HAUS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051225 spindle assembly IMP 19369198
GO:0051297 centrosome organization IMP 19427217
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with HAUS1: view

No data available for Pathways by source for HAUS1 Gene

Transcripts for HAUS1 Gene

Unigene Clusters for HAUS1 Gene

HAUS augmin-like complex, subunit 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAUS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAUS1 Gene

No ASD Table

Relevant External Links for HAUS1 Gene

GeneLoc Exon Structure for
HAUS1
ECgene alternative splicing isoforms for
HAUS1

Expression for HAUS1 Gene

mRNA expression in normal human tissues for HAUS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HAUS1 Gene

SOURCE GeneReport for Unigene cluster for HAUS1 Gene Hs.436617

mRNA Expression by UniProt/SwissProt for HAUS1 Gene

Q96CS2-HAUS1_HUMAN
Tissue specificity: Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver and heart. Weakly expressed in lung, brain and placenta.
genes like me logo Genes that share expressions with HAUS1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HAUS1 Gene

Orthologs for HAUS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAUS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAUS1 35
  • 100 (n)
  • 100 (a)
HAUS1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HAUS1 35
  • 88.73 (n)
  • 88.85 (a)
HAUS1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAUS1 35
  • 90.17 (n)
  • 92.09 (a)
HAUS1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Haus1 35
  • 83.93 (n)
  • 84.17 (a)
Haus1 16
Haus1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HAUS1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAUS1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912125 35
  • 84.17 (n)
  • 85.25 (a)
chicken
(Gallus gallus)
Aves HAUS1 35
  • 61.92 (n)
  • 50.73 (a)
HAUS1 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HAUS1 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia haus1 35
  • 59.98 (n)
  • 56.57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4754 35
zebrafish
(Danio rerio)
Actinopterygii haus1 35
  • 51.78 (n)
  • 42.44 (a)
haus1 36
  • 40 (a)
OneToOne
Species with no ortholog for HAUS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAUS1 Gene

ENSEMBL:
Gene Tree for HAUS1 (if available)
TreeFam:
Gene Tree for HAUS1 (if available)

Paralogs for HAUS1 Gene

Pseudogenes.org Pseudogenes for HAUS1 Gene

genes like me logo Genes that share paralogs with HAUS1: view

No data available for Paralogs for HAUS1 Gene

Variants for HAUS1 Gene

Sequence variations from dbSNP and Humsavar for HAUS1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs513160 -- 46,117,833(+) cccag(C/T)tactc intron-variant
rs562204 -- 46,115,782(+) atcat(C/G)agaat intron-variant
rs562206 -- 46,115,784(+) catga(A/G)aattt intron-variant
rs1262453 -- 46,116,509(+) tgagc(C/T)gagat intron-variant
rs1271148 -- 46,116,327(+) gaggc(C/T)gaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAUS1 Gene

Variant ID Type Subtype PubMed ID
esv1334297 CNV Insertion 17803354
esv2668326 CNV Deletion 23128226
dgv595e199 CNV Deletion 23128226

Relevant External Links for HAUS1 Gene

HapMap Linkage Disequilibrium report
HAUS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAUS1 Gene

Disorders for HAUS1 Gene

No disorders were found for HAUS1 Gene.

No data available for UniProtKB/Swiss-Prot for HAUS1 Gene

Publications for HAUS1 Gene

  1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis. (PMID: 15082789) Einarson M.B. … Golemis E.A. (Mol. Cell. Biol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R. … Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4

Products for HAUS1 Gene

Sources for HAUS1 Gene

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