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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HAUS1 Gene

protein-coding   GIFtS: 48
GCID: GC18P043684

HAUS augmin-like complex, subunit 1

(Previous name: coiled-coil domain containing 5 (spindle associated) )
(Previous symbol: CCDC5)
 Explore 2 diseases affiliated with
HAUS1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HAUS1    

Aliases
for HAUS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
HAUS Augmin-Like Complex, Subunit 11 2     Coiled-Coil Domain Containing 5 (Spindle Associated)1 2
CCDC51 2 3 5     Coiled-Coil Domain-Containing Protein 52 3
HEI-C1 2 3     Enhancer Of Invasion-Cluster2 3
HEIC2 3 5     FLJ400841
HsT14611 2     HAUS Augmin-Like Complex Subunit 12

External Ids:    HGNC: 251741   Entrez Gene: 1151062   Ensembl: ENSG000001522407   OMIM: 6087755   UniProtKB: Q96CS23   
ORGUL members:         
NONCODE:n407523    

Export aliases for HAUS1 gene to outside databases

Previous GC identifers: GC18P041940 GC18P040541


Summaries
for HAUS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HAUS1:
HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified
in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a
microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic
spindle assembly (Goshima et al., 2008 (PubMed 18443220); Uehara et al., 2009 (PubMed 19369198)).(supplied by OMIM,
Jun 2010)

UniProtKB/Swiss-Prot: HAUS1_HUMAN, Q96CS2
Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as
part of the HAUS augmin-like complex

Gene Wiki entry for HAUS1 (CCDC5)


Genomic Views
for HAUS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HAUS1 gene promoter:
         Spz1   AML1a   CUTL1   NF-kappaB   POU3F2   N-Myc   Egr-2   CREB   deltaCREB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HAUS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HAUS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAUS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

HAUS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAUS1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P043684:  view genomic region     (about GC identifiers)

Start:
 43,684,298 bp from pter      End:
 43,708,299 bp from pter
Size:
 24,002 bases      Orientation:
 plus strand

Proteins
for HAUS1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HAUS1_HUMAN, Q96CS2 (See protein sequence)
Recommended Name: HAUS augmin-like complex subunit 1  
Size: 278 amino acids; 31863 Da
Subunit: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this
interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is
strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct
or indirect
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm,
cytoskeleton, spindle pole. Note=Localizes with the spindle poles in mitotic cells. In metaphase, localizes to the
mitotic asters and is highly punctate on the microtubule array. During later stages of mitosis, remains on the spindle
but is not present at the interzone, and is finally observed at the microtubule bundles proximal to the midbody,
clearly excluded from the midbody. In contrast, does not colocalize with the tubulin cytoskeleton in interphase cells.
In interphase, localized at the centrosome and diffusely in the cytoplasm
Miscellaneous: HAUS1-depleted cells retain functional cell cycle checkpoints, but the depletion decreases the G2/M cell
cycle compartment and induces apoptosis. The protein level remains constant through the cell cycle
Sequence caution: Sequence=BAC05036.1; Type=Frameshift; Positions=15;
Secondary accessions: B2RDM7 Q8N837
Alternative splicing: 2 isoforms:  Q96CS2-1   Q96CS2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HAUS1: NX_Q96CS2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96CS2

    • HAUS1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_612452.1  
    ENSEMBL proteins: 
     ENSP00000282058   ENSP00000468575   ENSP00000466364   ENSP00000465093   ENSP00000465492  
     ENSP00000467975   ENSP00000466715   ENSP00000465622  

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    Uscn Proteins for HAUS1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005874microtubule IEA--
    GO:0070652HAUS complex IDA19369198


    HAUS1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for HAUS1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HAUS1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026243 HAUS1

    Graphical View of Domain Structure for InterPro Entry Q96CS2

    ProtoNet protein and cluster: Q96CS2

    UniProtKB/Swiss-Prot: HAUS1_HUMAN, Q96CS2
    Similarity: Belongs to the HAUS1 family


    Function
    for HAUS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HAUS1_HUMAN, Q96CS2
    Function: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as
    part of the HAUS augmin-like complex

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--


    HAUS1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HAUS1:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for HAUS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HAUS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/21 Interacting proteins for HAUS1 (Q96CS22, 3 ENSP000002820584) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ORC1Q134152, 3, ENSP000003606214MINT-50396 I2D: score=1 STRING: ENSP00000360621
    CDKN2AP427712, 3MINT-50398 I2D: score=1 
    CDT1Q9H2112, 3, ENSP000003010194MINT-50422 I2D: score=1 STRING: ENSP00000301019
    MCM3P252052, 3, ENSP000002298544MINT-50394 I2D: score=2 STRING: ENSP00000229854
    MCM4P339912, 3, ENSP000002621054MINT-50395 I2D: score=1 STRING: ENSP00000262105
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0051225spindle assembly IMP19369198
    GO:0051297centrosome organization IMP19427217
    GO:0051301cell division IEA--


    HAUS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HAUS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HAUS1
    Search CenterWatch for drugs/clinical trials and news about HAUS1 

    Transcripts
    for HAUS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HAUS1 gene: 
    NM_138443.3  

    Unigene Cluster for HAUS1:

    HAUS augmin-like complex, subunit 1
    Hs.436617  [show with all ESTs]
    Unigene Representative Sequence: BM799713
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282058(uc002lbv.3 uc002lbu.3) ENST00000592471 ENST00000591098
    ENST00000586060 ENST00000591715 ENST00000592206 ENST00000585518 ENST00000589554
    ENST00000593165 ENST00000588704 ENST00000585425

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK024747.1 AK097403.1 AK315605.1 AY360137.1 BC005958.1 BC014003.2 NR_026978.1 

    15 DOTS entries:

    DT.447650  DT.100703034  DT.100032516  DT.95274939  DT.121095212  DT.92433881  DT.92433867  DT.100037166 
    DT.121095097  DT.100846667  DT.121095197  DT.121095315  DT.120809073  DT.92433879  DT.216234 

    24/230 AceView cDNA sequences (see all 230):

    CR601181 CK820529 AA706737 AI040554 BF590727 AK097403 AI818457 AI031680 
    BM558725 BC014003 CD514777 BU172810 AA361156 AI366685 AI221810 BM473802 
    BQ013517 BU182083 AI298675 BM758655 AI417824 BU630106 BX280867 BU193260 

    GeneLoc Exon Structure


    Expression
    for HAUS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HAUS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGAACTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HAUS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HAUS1

    SOURCE GeneReport for Unigene cluster: Hs.436617

    UniProtKB/Swiss-Prot: HAUS1_HUMAN, Q96CS2
    Tissue specificity: Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver and heart. Weakly expressed
    in lung, brain and placenta

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    In Situ
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    Orthologs
    for HAUS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HAUS1 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Haus11 , 5 HAUS augmin-like complex, subunit 11, 5 83.93(n)1
    84.17(a)1    		   18 (52.38 cM)5
    2257451  NM_146089.21  NP_666201.11 
     777575675 
    chicken
    (Gallus gallus)    		 Aves HAUS11 HAUS augmin-like complex, subunit 1 61.92(n)
    50.73(a)    		   416380  NM_001030625.1  NP_001025796.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HAUS16
    		 --
    		 59(a)
    		 1 ↔ 1
    		 1(35069342-35081133)
    zebrafish
    (Danio rerio)    		 Actinopterygii haus11 HAUS augmin-like complex, subunit 1 51.78(n)
    42.44(a)    		   553389  XM_001343499.1  XP_001343535.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G413501 hypothetical protein 39.61(n)
    29.8(a)    		   818733  NM_001036447.2  NP_001031524.1 
    rice
    (Oryza sativa)    		 Liliopsida Os08g02406001 hypothetical protein 37.72(n)
    25.44(a)    		   4345035  NM_001067869.2  NP_001061334.2 


    ENSEMBL Gene Tree for HAUS1 (if available)
    TreeFam Gene Tree for HAUS1 (if available) 

    Paralogs
    for HAUS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HAUS1 gene

    HAUS1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for HAUS1
    PGOHUM00000235776 PGOHUM00000249386 PGOHUM00000241659


    Genomic Variants
    for HAUS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/455 NCBI SNPs in HAUS1 are shown (see all 455)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1474176741,2
    		--43686315(+) CTGTAG/TTTCCA 2 -- int10--------
    rs118729541,2
    		C,F,H,--43686450(+) AAAGAA/GAAAAA 2 -- int1 trp36Minor allele frequency- G:0.27NA WA 246
    rs1914196611,2
    		--43686462(+) AAAAAA/GTGCAT 2 -- int10--------
    rs1827391151,2
    		--43686473(+) TCAAGA/TTGCCT 2 -- int10--------
    rs118729851,2
    		C,F,H,--43686578(+) GCCCTA/GTATTT 2 -- int16Minor allele frequency- G:0.20NA WA EA 364
    rs1390893321,2
    		--43686749(+) GCCAAA/GGTGGG 2 -- int10--------
    rs1870719771,2
    		--43686840(+) GCCAGC/GTGTGG 2 -- int10--------
    rs1498947791,2
    		--43686886(+) TGAGGA/CGGGAG 2 -- int10--------
    rs1917080521,2
    		--43686906(+) AACCCA/GGGAGG 2 -- int10--------
    rs2009324831,2
    		--43686984(+) ACAAC-/AAAAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for HAUS1 (43684298 - 43708299 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HAUS1: --

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    Disorders / Diseases
    for HAUS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HAUS1 for disorders           About GeneDecksing

    OMIM gene information: 608775    OMIM disorders: --

    2 diseases for HAUS1:    About MalaCards
    newcastle disease    cholera


    Export disorders for HAUS1 gene to outside databases

    Publications
    for HAUS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HAUS1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with HAUS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PubMed id 19427217)1, 2, 3 Lawo S....Pelletier L. (2009)
    2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PubMed id 19369198)1, 2 Uehara R....Goshima G. (2009)
    3. Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis. (PubMed id 15082789)1, 2 Einarson M.B.... Golemis E.A. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for HAUS1 gene

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    Genome Databases showing HAUS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115106 HGNC: 25174 AceView: CCDC5 Ensembl:ENSG00000152240 euGenes: HUgn115106
    ECgene: HAUS1 H-InvDB: HAUS1

    Other Databases showing HAUS1 gene

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    Specialized Databases showing HAUS1 gene

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    PharmGKB entry for HAUS1 Pharmacogenomics, SNPs, Pathways

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