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HAT1 Gene

protein-coding   GIFtS: 68
GCID: GC02P172779

Histone Acetyltransferase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Acetyltransferase 11 2 3
KAT12 3
Histone Acetyltransferase Type B Catalytic Subunit2
EC 2.3.1.483

External Ids:    HGNC: 48211   Entrez Gene: 85202   Ensembl: ENSG000001287087   OMIM: 6030535   UniProtKB: O149293   

Export aliases for HAT1 gene to outside databases

Previous GC identifers: GC02P170830 GC02P171320 GC02P172742 GC02P172981 GC02P172604 GC02P172487 GC02P164663


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAT1 Gene:
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid
acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo
deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in
replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal
histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript
variants have been identified for this gene. (provided by RefSeq, Jun 2009)

GeneCards Summary for HAT1 Gene:
HAT1 (histone acetyltransferase 1) is a protein-coding gene. GO annotations related to this gene include histone acetyltransferase activity.

UniProtKB/Swiss-Prot: HAT1_HUMAN, O14929
Function: Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a
lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies
lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair
as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage

Gene Wiki entry for HAT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAT1 gene promoter:
         STAT1   Sox5   Pax-5   HOXA3   CUTL1   LCR-F1   C/EBPalpha   POU2F1   HNF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAT1 promoter sequence
   Search Chromatin IP Primers for HAT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.2-q33.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.2-q33.1

HAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAT1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P172779:  view genomic region     (about GC identifiers)

Start:
172,778,935 bp from pter      End:
172,848,600 bp from pter
Size:
69,666 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HAT1_HUMAN, O14929 (See protein sequence)
Recommended Name: Histone acetyltransferase type B catalytic subunit  
Size: 419 amino acids; 49513 Da
Subunit: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1.
Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the
N-terminus of histones. Component of the histone H3.1 and H3.3 complexes
Developmental stage: Highly expressed in mitotic cells (at protein level)
Sequence caution: Sequence=AAH18682.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for HAT1:
2P0W (3D)    
Secondary accessions: Q49A44 Q53QF0 Q53SU4 Q6P594 Q8WWB9
Alternative splicing: 2 isoforms:  O14929-1   O14929-2   

Explore the universe of human proteins at neXtProt for HAT1: NX_O14929

Explore proteomics data for HAT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys9, Lys15, Lys26, Lys70
  • Modification sites at PhosphoSitePlus

  • See HAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003633.1  
    ENSEMBL proteins: 
     ENSP00000407921   ENSP00000403466   ENSP00000264108   ENSP00000376363  
    Reactome Protein details: O14929

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    ProSpec Recombinant Protein for HAT1
    Cloud-Clone Corp. Proteins for HAT1

     
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    antibodies-online proteins for HAT1 (24 products) 

     
    antibodies-online peptides for HAT1

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    antibodies-online kits for HAT1 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KAT: Chromatin-modifying enzymes / K-acetyltransferases

    3 InterPro protein domains:
     IPR017380 Hist_AcTrfase_B-typ_cat-su
     IPR019467 Hat1_N
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry O14929

    ProtoNet protein and cluster: O14929

    UniProtKB/Swiss-Prot: HAT1_HUMAN, O14929
    Similarity: Belongs to the HAT1 family


    Find genes that share domains with HAT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HAT1_HUMAN, O14929
    Function: Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a
    lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies
    lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair
    as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]
    Induction: Up-regulated by estrogen

         Genatlas biochemistry entry for HAT1:
    histone actyltransferase 1,catalytic subunit,acetylating soluble (not nucleosomal) newly synthesized histone H4 at
    Lys5 and Lys12,and H2A at Lys5,expressed in the nucleus of S-phase cells,likely involved in generating modified
    H4 required for replication-dependent chromatin remodeling

         Enzyme Number (IUBMB): EC 2.3.1.481

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004402histone acetyltransferase activity IEA--
    GO:0005515protein binding IPI19862764
         
    Find genes that share ontologies with HAT1           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hat1):
     cellular  craniofacial  growth/size/body  mortality/aging  normal 
     respiratory system  skeleton 

    Find genes that share phenotypes with HAT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hat1tm1.1Mrpa for HAT1

       genOway: Develop your customized and physiologically relevant rodent model for HAT1

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    1 qRT-PCR Assays for microRNA that regulate HAT1:
    hsa-miR-486-5p
    SwitchGear 3'UTR luciferase reporter plasmidHAT1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HAT1_HUMAN, O14929: Isoform A: Nucleus matrix
    HAT1_HUMAN, O14929: Isoform B: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Note=Localization is
    predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear
    localization through redistribution of existing protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0016363nuclear matrix IEA--

    Find genes that share ontologies with HAT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HAT1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    Alcoholism0.34
    2Assembly of RNA Polymerase-II Initiation Complex
    Protein Acetylation and Deacetylation0.51
    Crosstalk Between CARM1 and ESRs0.39
    3Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    4ERK Signaling
    Molecular Mechanisms of Cancer0.51
    5ErbB4 Pathway
    HMGB1 Pathway0.36


    Find genes that share SuperPaths with HAT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HAT1 (see all 6)
        Nuclear Receptor Activation by Vitamin-A
    Notch Signaling
    Protein Acetylation and Deacetylation
    HMGB1 Pathway
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for HAT1
        EGFR1 Signaling Pathway


    1 Reactome Pathway for HAT1
        HATs acetylate histones


    1 Kegg Pathway  (Kegg details for HAT1):
        Alcoholism

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HAT1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HAT1 (O149291, 2, 3 ENSP000002641084) via UniProtKB, MINT, STRING, and/or I2D (see all 203)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628051, 2, 3, ENSP000002893524EBI-2339359,EBI-302023 MINT-7220359 I2D: score=10 STRING: ENSP00000289352
    HIST4H4P628051, 2, 3, ENSP000003507674EBI-2339359,EBI-302023 MINT-7220359 I2D: score=10 STRING: ENSP00000350767
    HIST1H4BP628051, 2, 3EBI-2339359,EBI-302023 MINT-7220359 I2D: score=10 
    HIST1H4CP628051, 2, 3EBI-2339359,EBI-302023 MINT-7220359 I2D: score=10 
    HIST1H4DP628051, 2, 3EBI-2339359,EBI-302023 MINT-7220359 I2D: score=10 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006323DNA packaging TAS9427644
    GO:0006325chromatin organization TAS--
    GO:0006348chromatin silencing at telomere IEA--
    GO:0006475internal protein amino acid acetylation TAS9427644
    GO:0007584response to nutrient IEA--

    Find genes that share ontologies with HAT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    1 ApexBio Compound for HAT1     About this table
    CompoundAction CAS #
    NU 9056Selective KAT5 (Tip60) histone acetyltransferase inhibitor--

    Browse Tocris compounds for HAT1

    2 HMDB Compounds for HAT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--

    3 Novoseek inferred chemical compound relationships for HAT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylmethanesulfonate 73.3 2 17052979 (1), 12417736 (1)
    lysine 44.2 1 12417736 (1)
    arginine 23.3 1 17409432 (1)



    Find genes that share compounds with HAT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HAT1 gene (2 alternative transcripts): 
    NM_003642.3  NM_001033085.1  

    Unigene Cluster for HAT1:

    Histone acetyltransferase 1
    Hs.632532  [show with all ESTs]
    Unigene Representative Sequence: AK127840
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412731 ENST00000460481 ENST00000457761 ENST00000264108(uc002uhi.3)
    ENST00000494601 ENST00000477327(uc010fqi.2) ENST00000392584(uc002uhj.3)

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    Additional mRNA sequence: 

    AF030424.1 AK127840.1 AK309001.1 AK313699.1 BC018682.1 BC063003.1 NR_027862.1 

    16 DOTS entries:

    DT.100649430  DT.455459  DT.100804890  DT.95244592  DT.97843891  DT.95171897  DT.101980132  DT.120943144 
    DT.101982935  DT.120943137  DT.75169363  DT.92435260  DT.91895216  DT.92435254  DT.95171900  DT.99935544 

    Selected AceView cDNA sequences (see all 182):

    CB144105 AA580942 CA424428 CB305860 CB119323 CB160511 BX342229 NM_003642 
    CK902259 BM983029 AI220803 AI810998 AA470458 AF030424 CB136713 CR592532 
    AI373083 AA765292 BM728899 AU098510 BC063003 CB160514 CB114285 BM785196 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HAT1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                          -     -                                                                                 
    SP2:                                                                                                                  
    SP3:                          -     -           -                                                                     
    SP4:                          -     -           -     -                                                               
    SP5:                                -                                                                                 


    ECgene alternative splicing isoforms for HAT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAGCTGGA
    HAT1 Expression
    About this image


    HAT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    HAT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HAT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632532
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HAT1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Telomeres & Telomerase in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HAT1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hat11 , 5 histone aminotransferase 11, 5 91.33(n)1
    93.73(a)1
      2 (42.38 cM)5
    1074351  NM_026115.41  NP_080391.21 
     713889585 
    chicken
    (Gallus gallus)
    Aves HAT11 histone acetyltransferase 1 81.8(n)
    83.13(a)
      374037  NM_204207.1  NP_989538.1 
    lizard
    (Anolis carolinensis)
    Reptilia HAT16
    histone acetyltransferase 1
    70(a)
    1 ↔ 1
    GL343353.1(572578-609699)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.101912 Xenopus laevis transcribed sequence with moderate similarity more 79.78(n)    BQ726785.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570893802   -- 70.39(n)    57089380 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG20511 , 3 histone acetyltransferase3
    CG20511
    39(a)3
    48.9(n)1
    40.86(a)1
      83C43
    407161  NM_169106.21  NP_731006.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M03C11.43
    hat-11
    hat-11 34(a)3
    46.52(n)1
    35.93(a)1
      III(10477492-10479332)3
    1764581  NM_066895.31  NP_499296.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HAT1(YPL001W)4
    HAT11
    Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase more4
    HAT11
    44.1(n)1
    29.49(a)1
      16(554605-555729)4
    8561061, 4  NP_015324.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HAG21 HAG2 42.59(n)
    28.53(a)
      835775  NM_125057.3  NP_200485.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g03478001 Os09g0347800 43.76(n)
    28.17(a)
      4346812  NM_001069481.1  NP_001062946.1 


    ENSEMBL Gene Tree for HAT1 (if available)
    TreeFam Gene Tree for HAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HAT1 gene

    Find genes that share paralogs with HAT1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HAT1
    PGOHUM00000249658


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HAT1 (see all 1278)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359974
    A colorectal cancer sample4--see VAR_0359972 A P mis40--------
    rs558932221,2
    C--172238104(+) TCTCT-/GAGT  
            
    CAGTT
    2 -- int11Minor allele frequency- GAGT:0.00NA 2
    rs3691506471,2
    C--172240398(+) AAATT-/AA/T  
            
    AAAAA
    2 -- int11NA 2
    rs67460511,2
    C--172777000(+) cgcctC/Tccagg 2 -- us2k14Minor allele frequency- T:0.00NA WA 8
    rs1495689421,2
    --172777228(+) TCTTGC/TGTATC 2 -- us2k10--------
    rs621824331,2
    C,F--172777331(+) GAGGTC/TGGGAG 2 -- us2k16Minor allele frequency- T:0.30NA WA CSA 10
    rs1482957531,2
    C--172777408(+) GTGGCA/GCATGC 2 -- us2k10--------
    rs1496709501,2
    --172777559(+) AAAAA-/GAAAG 
            
    AAAAA
    2 -- us2k10--------
    rs1867855551,2
    --172777753(+) TGAGAA/GGGCGT 2 -- us2k10--------
    rs1920947041,2
    --172777772(+) TAGACC/TATCAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HAT1 (172778935 - 172848600 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HAT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661889CNV Deletion23128226
    esv2666693CNV Deletion23128226
    nsv436276CNV Deletion17901297
    dgv4362n71CNV Loss21882294
    nsv821790CNV Loss20364138
    nsv821789CNV Loss20364138
    esv27070CNV Loss19812545
    nsv442838CNV CNV18776908
    nsv514102CNV Complex21397061

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for HAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603053    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for HAT1:
    Scheuermann's disease

    Find genes that share disorders with HAT1           About GenesLikeMe

    Genetic Association Database (GAD): HAT1
    Human Genome Epidemiology (HuGE) Navigator: HAT1 (1 document)

    Export disorders for HAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HAT1 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with HAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. (PubMed id 9427644)1, 2, 3 Verreault A.... Stillman B. (Curr. Biol. 1998)
    2. The program for processing newly synthesized histones H3.1 and H4. (PubMed id 20953179)1, 2 Campos E.I.... Reinberg D. (Nat. Struct. Mol. Biol. 2010)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase. (PubMed id 11585814)1, 2 Makowski A.M.... Annunziato A.T. (J. Biol. Chem. 2001)
    6. Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair. (PubMed id 17052979)1, 9 Benson L.J....Annunziato A.T. (J. Biol. Chem. 2007)
    7. Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance. (PubMed id 18458078)1, 9 Miyamoto N....Kohno K. (J. Biol. Chem. 2008)
    8. Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach. (PubMed id 23281010)1 Li X....Kapoor T.M. (Protein Sci. 2013)
    9. HIV-1 Vpr Induces the Degradation of ZIP and sZIP, Adaptors of the NuRD Chromatin Remodeling Complex, by Hijacking DCAF1/VprBP. (PubMed id 24116224)1 Maudet C.... Margottin-Goguet F. (PLoS ONE 2013)
    10. Histone acetyltransferase 1 promotes homologous recombination in DNA repair by facilitating histone turnover. (PubMed id 23653357)1 Yang X....Shang Y. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8520 HGNC: 4821 AceView: HAT1 Ensembl:ENSG00000128708 euGenes: HUgn8520
    ECgene: HAT1 Kegg: 8520 H-InvDB: HAT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HAT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HAT1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Histone_acetyltransferase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HAT1 gene:
    Search GeneIP for patents involving HAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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