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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HAT1 Gene

protein-coding GIFtS: 63
GCID: GC02P172742

histone acetyltransferase 1

Explore 6 diseases affiliated with
HAT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Histone Acetyltransferase 1¹ ² ³
KAT1¹ ² ³
Histone Acetyltransferase Type B Catalytic Subunit²
EC 2.3.1.48³

External Ids:	HGNC: 4821¹	Entrez Gene: 8520²	Ensembl: ENSG00000128708⁷	OMIM: 603053⁵	UniProtKB: O14929³

ORGUL members:
	NONCODE:n408054

Export aliases for HAT1 gene to outside databases

Previous GC identifers: GC02P170830 GC02P171320 GC02P172981 GC02P172604 GC02P172487 GC02P164663

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HAT1:

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation

of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto

nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent

chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12,

and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for

this gene. (provided by RefSeq, Jun 2009)

UniProtKB/Swiss-Prot: HAT1_HUMAN, O14929

Function: Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser

extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in

recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the

histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage

Gene Wiki entry for HAT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HAT1 gene promoter:
STAT1 Sox5 Pax-5 HOXA3 CUTL1 LCR-F1 C/EBPalpha POU2F1 HNF-1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HAT1 promoter sequence

Search SABiosciences Chromatin IP Primers for HAT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.2-q33.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.2-q33.1

HAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAT1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P172742: view genomic region (about GC identifiers)

Start:	172,778,935 bp from pter	End:	172,848,600 bp from pter
Size:	69,666 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HAT1_HUMAN, O14929 (See protein sequence)

Recommended Name: Histone acetyltransferase type B catalytic subunit

Size: 419 amino acids; 49513 Da

Subunit: Catalytic subunit of the type B histone acetlytransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts

with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones.

Component of the histone H3.1 and H3.3 complexes

Subcellular location: Isoform A: Nucleus matrix

Subcellular location: Isoform B: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Note=Localization is

predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear

localization through redistribution of existing protein

Developmental stage: Highly expressed in mitotic cells (at protein level)

Sequence caution: Sequence=AAH18682.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

1 PDB 3D structure from and Proteopedia for HAT1:

2P0W (3D)

Secondary accessions: Q49A44 Q53QF0 Q53SU4 Q6P594 Q8WWB9

Alternative splicing: 2 isoforms: O14929-1 O14929-2

Explore the universe of human proteins at neXtProt for HAT1: NX_O14929

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14929

HAT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003633.1

ENSEMBL proteins:

ENSP00000407921 ENSP00000403466 ENSP00000264108 ENSP00000376363

Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for HAT1
	Uscn Proteins for HAT1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	IEA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--
GO:0016363	nuclear matrix	IEA	--

HAT1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for HAT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HAT1 for domains About GeneDecksing

3 InterPro domains/families:

IPR017380 Hist_AcTrfase_B-typ_cat-su

IPR019467 Hat1_N

IPR016181 Acyl_CoA_acyltransferase

Graphical View of Domain Structure for InterPro Entry O14929

ProtoNet protein and cluster: O14929

UniProtKB/Swiss-Prot: HAT1_HUMAN, O14929

Similarity: Belongs to the HAT1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HAT1_HUMAN, O14929

Function: Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser

extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in

recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the

histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage

Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

Induction: Up-regulated by estrogen

Genatlas biochemistry entry for HAT1:

histone actyltransferase 1,catalytic subunit,acetylating soluble (not nucleosomal) newly synthesized histone H4 at Lys5

and Lys12,and H2A at Lys5,expressed in the nucleus of S-phase cells,likely involved in generating modified H4 required

for replication-dependent chromatin remodeling

Enzyme Number (IUBMB): EC 2.3.1.48¹

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAT1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004402	histone acetyltransferase activity	IEA	--
GO:0005515	protein binding	IPI	--

HAT1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Assembly of RNA Polymerase-II Initiation Complex

Protein Acetylation and Deacetylation

0.51

Crosstalk Between CARM1 and ESRs

0.32

EGFR1 Signaling Pathway

EGFR1 Signaling Pathway

1.00

Apoptotic Pathways in Synovial Fibroblasts

Nuclear Receptor Activation by Vitamin-A

0.57

Rho Family GTPases

Molecular Mechanisms of Cancer

0.51

ErbB4 Pathway

HMGB1 Pathway

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for HAT1

Histone modification

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HAT1 (see all 6)

	Nuclear Receptor Activation by Vitamin-A
	Notch Signaling
	Protein Acetylation and Deacetylation
	HMGB1 Pathway
	Molecular Mechanisms of Cancer

1 BioSystems Pathway for HAT1

EGFR1 Signaling Pathway

HAT1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HAT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/143 Interacting proteins for HAT1 (O14929^{1, 2, 3} ENSP00000264108⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 143)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST4H4	P62805¹^,²^,³, ENSP00000350767⁴	EBI-2339359,EBI-302023 MINT-7220359 I2D: score=10 STRING: ENSP00000350767
HIST1H4B	P62805¹^,²^,³	EBI-2339359,EBI-302023 MINT-7220359 I2D: score=10
HIST1H4C	P62805¹^,²^,³	EBI-2339359,EBI-302023 MINT-7220359 I2D: score=10
HIST1H4D	P62805¹^,²^,³	EBI-2339359,EBI-302023 MINT-7220359 I2D: score=10
HIST1H4E	P62805¹^,²^,³	EBI-2339359,EBI-302023 MINT-7220359 I2D: score=10

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006323	DNA packaging	TAS	9427644
GO:0006348	chromatin silencing at telomere	IEA	--
GO:0006475	internal protein amino acid acetylation	TAS	9427644
GO:0007584	response to nutrient	IEA	--
GO:0016573	histone acetylation	--	--

HAT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HAT1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HAT1

2 HMDB Compounds for HAT1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Coenzyme A	Acetoacetyl coenzyme A sodium salt (see all 21)	85-61-0	--

3 Novoseek chemical compound relationships for HAT1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
methylmethanesulfonate	73.3	2	17052979 (1), 12417736 (1)
lysine	44.2	1	12417736 (1)
arginine	23.3	1	17409432 (1)

Search CenterWatch for drugs/clinical trials and news about HAT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HAT1 gene (2 alternative transcripts):

NM_003642.3 NM_001033085.1

Unigene Cluster for HAT1:

Histone acetyltransferase 1

Hs.632532 [show with all ESTs]

Unigene Representative Sequence: AK127840

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000412731 ENST00000460481 ENST00000457761 ENST00000264108(uc002uhi.3)

ENST00000494601 ENST00000477327(uc010fqi.2) ENST00000392584(uc002uhj.3)

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Additional cDNA sequence:

AF030424.1 AK127840.1 AK309001.1 AK313699.1 BC018682.1 BC063003.1 NR_027862.1

16 DOTS entries:

DT.100649430 DT.455459 DT.100804890 DT.95244592 DT.97843891 DT.95171897 DT.101980132 DT.120943144

DT.101982935 DT.120943137 DT.75169363 DT.92435260 DT.91895216 DT.92435254 DT.95171900 DT.99935544

24/182 AceView cDNA sequences (see all 182):

CB136713 CB144105 AI810998 AF030424 CK902259 AA470458 BM983029 BM771033

AA022845 CR592532 BM757795 CB305860 CA424428 AA580942 CB160511 NM_003642

CB119323 BX342229 AI373083 BC063003 AA765292 CB114285 BM785196 AU098510

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HAT1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b
SP1:									-		-
SP2:
SP3:									-		-				-
SP4:									-		-				-		-
SP5:											-

ECgene alternative splicing isoforms for HAT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HAT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAGCTGGA

About this image

HAT1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HAT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HAT1

SOURCE GeneReport for Unigene cluster: Hs.632532

SABiosciences Expression via Pathway-Focused PCR Arrays including HAT1:

Epigenetic Chromatin Modification Enzymes in human mouse rat

Mesenchymal Stem Cell in human mouse rat

Telomeres & Telomerase in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HAT1 gene from 10/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hat1^{1 , 5}	histone aminotransferase 1^{1, 5}	91.47(n)¹ 93.96(a)¹		2 (42.38 cM)⁵ 107435¹ NM_026115.4¹ NP_080391.2¹ 71388958⁵
chicken (Gallus gallus)	Aves	HAT1¹	histone acetyltransferase 1	81.96(n) 83.54(a)		374037 NM_204207.1 NP_989538.1
lizard (Anolis carolinensis)	Reptilia	HAT1⁶	--	78(a)	1 ↔ 1	GL343353.1(575335-606589)
African clawed frog (Xenopus laevis)	Amphibia	Xl.10191²	Xenopus laevis transcribed sequence with moderate similarity more	79.78(n)		BQ726785.1
zebrafish (Danio rerio)	Actinopterygii	57089380²	--	70.39(n)		57089380
fruit fly (Drosophila melanogaster)	Insecta	CG2051^{1 , 3}	histone acetyltransferase³ CG2051¹	39(a)³ 48.27(n)¹ 40.25(a)¹		83C4³ 40716¹ NM_141330.2¹ NP_649587.1¹
worm (Caenorhabditis elegans)	Secernentea	M03C11.4³ hat-1¹	Protein HAT-1¹	34(a)³ 46.43(n)¹ 35.93(a)¹		III(10477492-10479332)³ 176458¹ NM_066895.2¹ NP_499296.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	HAT1(YPL001W)⁴ HAT1¹	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase more⁴ Hat1p¹	43.82(n)¹ 28.93(a)¹		16(554605-555729)⁴ 856106^{1, 4} NP_015324.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	HAG2¹	histone acetyltransferase type B catalytic subunit	42.59(n) 28.53(a)		835775 NM_125057.3 NP_200485.1
rice (Oryza sativa)	Liliopsida	Os09g0347800¹	hypothetical protein	44.41(n) 27.9(a)		4346812 NM_001069481.1 NP_001062946.1

ENSEMBL Gene Tree for HAT1 (if available)
TreeFam Gene Tree for HAT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HAT1 gene

HAT1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for HAT1
PGOHUM00000249658

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6746051^1,2	C,	--	172777000(+)	`CGCCTC/TCCAGG`	2	--	us2k¹		4		NA WA	8
rs149568942^1,2		--	172777228(+)	`TCTTGC/TGTATC`	2	--	us2k¹		0	--	--	--	--
rs62182433^1,2	C,F,	--	172777331(+)	`GAGGTC/TGGGAG`	2	--	us2k¹		6		NA WA CSA	10
rs148295753^1,2		--	172777408(+)	`GTGGCA/GCATGC`	2	--	us2k¹		0	--	--	--	--
rs149670950^1,2		--	172777559(+)	`AAAAA-/GAAAG AAAAA`	2	--	us2k¹		0	--	--	--	--
rs186785555^1,2		--	172777753(+)	`TGAGAA/GGGCGT`	2	--	us2k¹		0	--	--	--	--
rs192094704^1,2		--	172777772(+)	`TAGACC/TATCAT`	2	--	us2k¹		0	--	--	--	--
rs183959654^1,2		--	172777837(+)	`ATTTGA/TTGAGA`	2	--	us2k¹		0	--	--	--	--
rs78418053^1,2	F,	--	172777995(+)	`AAACCA/TCTAGG`	2	--	us2k¹		1		NA	120
rs77027443^1,2	F,	--	172778014(+)	`CATGCA/CAGACT`	2	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for HAT1 (172778935 - 172848600 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for HAT1
5 CNVs: 90128 78853 37937 63234 22832

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HAT1 for disorders           About GeneDecksing

OMIM gene information: 603053    OMIM disorders: --

6 diseases for HAT1:    About MalaCards

liver sarcoma sarcoma ovarian cancer colorectal cancer

breast cancer immunodeficiency

Human Genome Epidemiology (HuGE) Navigator: HAT1 (1 document)

Export disorders for HAT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HAT1 gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with HAT1)

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Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. (PubMed id 9427644)^{1, 2, 3} Verreault A.... Stillman B. (1998)
The program for processing newly synthesized histones H3.1 and H4. (PubMed id 20953179)^{1, 2} Campos E.I.... Reinberg D. (2010)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase. (PubMed id 11585814)^{1, 2} Makowski A.M....Annunziato A.T. (2001)
Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair. (PubMed id 17052979)^{1, 9} Benson L.J....Annunziato A.T. (2007)
Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance. (PubMed id 18458078)^{1, 9} Miyamoto N....Kohno K. (2008)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8520	HGNC: 4821	AceView: HAT1	Ensembl:ENSG00000128708	euGenes: HUgn8520
ECgene: HAT1	H-InvDB: HAT1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HAT1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HAT1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Histone_acetyltransferase

Intellectual Property for HAT1 gene
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Patent Information for HAT1 gene:
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