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Aliases for HAT1 Gene

Aliases for HAT1 Gene

  • Histone Acetyltransferase 1 2 3 4 5
  • KAT1 3 4
  • EC 2.3.1.48 4

External Ids for HAT1 Gene

Previous GeneCards Identifiers for HAT1 Gene

  • GC02P170830
  • GC02P171320
  • GC02P172742
  • GC02P172981
  • GC02P172604
  • GC02P172487
  • GC02P164663
  • GC02P172779

Summaries for HAT1 Gene

Entrez Gene Summary for HAT1 Gene

  • The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]

GeneCards Summary for HAT1 Gene

HAT1 (Histone Acetyltransferase 1) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include histone acetyltransferase activity and H4 histone acetyltransferase activity.

UniProtKB/Swiss-Prot for HAT1 Gene

  • Acetylates soluble but not nucleosomal histone H4 at Lys-5 (H4K5ac) and Lys-12 (H4K12ac) and, to a lesser extent, acetylates histone H2A at Lys-5 (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.

Gene Wiki entry for HAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAT1 Gene

Genomics for HAT1 Gene

Regulatory Elements for HAT1 Gene

Enhancers for HAT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HAT1 on UCSC Golden Path with GeneCards custom track

Promoters for HAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HAT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HAT1 Gene

Chromosome:
2
Start:
171,922,425 bp from pter
End:
171,983,686 bp from pter
Size:
61,262 bases
Orientation:
Plus strand

Genomic View for HAT1 Gene

Genes around HAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAT1 Gene

Proteins for HAT1 Gene

  • Protein details for HAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14929-HAT1_HUMAN
    Recommended name:
    Histone acetyltransferase type B catalytic subunit
    Protein Accession:
    O14929
    Secondary Accessions:
    • Q49A44
    • Q53QF0
    • Q53SU4
    • Q6P594
    • Q8WWB9

    Protein attributes for HAT1 Gene

    Size:
    419 amino acids
    Molecular mass:
    49513 Da
    Quaternary structure:
    • Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes.
    SequenceCaution:
    • Sequence=AAH18682.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HAT1 Gene

    Alternative splice isoforms for HAT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAT1 Gene

Proteomics data for HAT1 Gene at MOPED

Post-translational modifications for HAT1 Gene

  • Ubiquitination at Lys 15, Lys 26, and Lys 70
  • Modification sites at PhosphoSitePlus

Other Protein References for HAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HAT1 Gene

Domains & Families for HAT1 Gene

Gene Families for HAT1 Gene

Protein Domains for HAT1 Gene

Suggested Antigen Peptide Sequences for HAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14929

UniProtKB/Swiss-Prot:

HAT1_HUMAN :
  • Belongs to the HAT1 family.
Family:
  • Belongs to the HAT1 family.
genes like me logo Genes that share domains with HAT1: view

Function for HAT1 Gene

Molecular function for HAT1 Gene

GENATLAS Biochemistry:
histone actyltransferase 1,catalytic subunit,acetylating soluble (not nucleosomal) newly synthesized histone H4 at Lys5 and Lys12,and H2A at Lys5,expressed in the nucleus of S-phase cells,likely involved in generating modified H4 required for replication-dependent chromatin remodeling
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6.68 uM for acetyl-CoA {ECO:0000269 PubMed:22615379}; Note=kcat is 4.14 (sec-1) for acetyl-CoA. {ECO:0000269 PubMed:22615379};
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Acetylates soluble but not nucleosomal histone H4 at Lys-5 (H4K5ac) and Lys-12 (H4K12ac) and, to a lesser extent, acetylates histone H2A at Lys-5 (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.
UniProtKB/Swiss-Prot Induction:
Up-regulated by estrogen.

Enzyme Numbers (IUBMB) for HAT1 Gene

genes like me logo Genes that share phenotypes with HAT1: view

Animal Models for HAT1 Gene

MGI Knock Outs for HAT1:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HAT1 Gene

Localization for HAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAT1 Gene

Isoform A: Nucleus matrix.
Isoform B: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Note=Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAT1 Gene COMPARTMENTS Subcellular localization image for HAT1 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016363 nuclear matrix IEA --
genes like me logo Genes that share ontologies with HAT1: view

Pathways & Interactions for HAT1 Gene

genes like me logo Genes that share pathways with HAT1: view

Pathways by source for HAT1 Gene

1 GeneTex pathway for HAT1 Gene
1 BioSystems pathway for HAT1 Gene

Gene Ontology (GO) - Biological Process for HAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006323 DNA packaging TAS 9427644
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
GO:0006348 chromatin silencing at telomere IEA --
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with HAT1: view

No data available for SIGNOR curated interactions for HAT1 Gene

Drugs & Compounds for HAT1 Gene

(4) Drugs for HAT1 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
C646 Pharma HAT p300-CBP inhibitor,cell-permeable 0
Coenzyme A Nutra 0

(2) Additional Compounds for HAT1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9

(1) ApexBio Compounds for HAT1 Gene

Compound Action Cas Number
C646 HAT p300-CBP inhibitor,cell-permeable 328968-36-1
genes like me logo Genes that share compounds with HAT1: view

Transcripts for HAT1 Gene

Unigene Clusters for HAT1 Gene

Histone acetyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - -
SP2:
SP3: - - -
SP4: - - - -
SP5: -
SP6:

Relevant External Links for HAT1 Gene

GeneLoc Exon Structure for
HAT1
ECgene alternative splicing isoforms for
HAT1

Expression for HAT1 Gene

mRNA expression in normal human tissues for HAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HAT1 Gene

This gene is overexpressed in Testis (7.0), Bone (6.9), and Fetal ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HAT1 Gene



SOURCE GeneReport for Unigene cluster for HAT1 Gene Hs.632532

genes like me logo Genes that share expression patterns with HAT1: view

Protein tissue co-expression partners for HAT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HAT1 Gene

Orthologs for HAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HAT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HAT1 35
  • 95.64 (n)
  • 98.31 (a)
HAT1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAT1 35
  • 95.31 (n)
  • 98.57 (a)
HAT1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hat1 35
  • 91.33 (n)
  • 93.73 (a)
Hat1 16
Hat1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HAT1 35
  • 99.84 (n)
  • 100 (a)
HAT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hat1 35
  • 92.28 (n)
  • 96.66 (a)
oppossum
(Monodelphis domestica)
Mammalia HAT1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAT1 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves HAT1 35
  • 81.8 (n)
  • 83.13 (a)
HAT1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HAT1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hat1 35
  • 74.11 (n)
  • 75.19 (a)
Str.4861 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10191 35
zebrafish
(Danio rerio)
Actinopterygii hat1 35
  • 68.25 (n)
  • 70.82 (a)
hat1 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2051 37
  • 39 (a)
CG2051 35
  • 48.9 (n)
  • 40.86 (a)
CG2051 36
  • 39 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003264 35
  • 45.29 (n)
  • 38.64 (a)
worm
(Caenorhabditis elegans)
Secernentea M03C11.4 37
  • 34 (a)
hat-1 35
  • 46.52 (n)
  • 35.93 (a)
hat-1 36
  • 32 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL001W 35
  • 48.05 (n)
  • 33.33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14301g 35
  • 48.89 (n)
  • 33.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAT1 35
  • 44.1 (n)
  • 29.49 (a)
HAT1 36
  • 26 (a)
OneToOne
HAT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons HAG2 35
  • 42.59 (n)
  • 28.53 (a)
rice
(Oryza sativa)
Liliopsida Os09g0347800 35
  • 43.76 (n)
  • 28.17 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06472 35
  • 42.19 (n)
  • 29.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hat1 35
  • 44.66 (n)
  • 30.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4751 36
  • 41 (a)
OneToOne
Species with no ortholog for HAT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HAT1 Gene

ENSEMBL:
Gene Tree for HAT1 (if available)
TreeFam:
Gene Tree for HAT1 (if available)

Paralogs for HAT1 Gene

Pseudogenes.org Pseudogenes for HAT1 Gene

genes like me logo Genes that share paralogs with HAT1: view

No data available for Paralogs for HAT1 Gene

Variants for HAT1 Gene

Sequence variations from dbSNP and Humsavar for HAT1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035997 A colorectal cancer sample
rs1982288 -- 171,965,218(+) TTTAC(G/T)TCTTT intron-variant
rs3030475 -- 171,969,690(-) TGACT(-/GATAATACT)TTGTT intron-variant
rs2028672 -- 171,942,284(-) aatat(A/G)tatta intron-variant
rs2028673 -- 171,942,259(-) aaaaa(A/T)aTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAT1 Gene

Variant ID Type Subtype PubMed ID
dgv4362n71 CNV Loss 21882294
esv2666693 CNV Deletion 23128226
nsv436276 CNV Deletion 17901297
esv2661889 CNV Deletion 23128226
esv27070 CNV Loss 19812545
nsv442838 CNV CNV 18776908
nsv514102 CNV Complex 21397061
nsv821789 CNV Loss 20364138
nsv821790 CNV Loss 20364138

Variation tolerance for HAT1 Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAT1 Gene

HapMap Linkage Disequilibrium report
HAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAT1 Gene

Disorders for HAT1 Gene

Relevant External Links for HAT1

Genetic Association Database (GAD)
HAT1
Human Genome Epidemiology (HuGE) Navigator
HAT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAT1

No disorders were found for HAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAT1 Gene

Publications for HAT1 Gene

  1. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. (PMID: 9427644) Verreault A. … Stillman B. (Curr. Biol. 1998) 2 3 4 67
  2. Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance. (PMID: 18458078) Miyamoto N. … Kohno K. (J. Biol. Chem. 2008) 3 23
  3. Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair. (PMID: 17052979) Benson L.J. … Annunziato A.T. (J. Biol. Chem. 2007) 3 23
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3

Products for HAT1 Gene

Sources for HAT1 Gene

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