External Ids for HAT1 Gene
Previous GeneCards Identifiers for HAT1 Gene
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
GeneCards Summary for HAT1 Gene
HAT1 (Histone Acetyltransferase 1) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include histone acetyltransferase activity and H4 histone acetyltransferase activity.
UniProtKB/Swiss-Prot for HAT1 Gene
Acetylates soluble but not nucleosomal histone H4 at Lys-5 (H4K5ac) and Lys-12 (H4K12ac) and, to a lesser extent, acetylates histone H2A at Lys-5 (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.