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Aliases for HAS3 Gene

Aliases for HAS3 Gene

  • Hyaluronan Synthase 3 2 3 5
  • Hyaluronic Acid Synthase 3 4
  • Hyaluronate Synthase 3 4
  • HA Synthase 3 4
  • EC 2.4.1.212 4

External Ids for HAS3 Gene

Previous GeneCards Identifiers for HAS3 Gene

  • GC16P059825
  • GC16P069517
  • GC16P068875
  • GC16P068916
  • GC16P067697
  • GC16P069140
  • GC16P055012

Summaries for HAS3 Gene

Entrez Gene Summary for HAS3 Gene

  • The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for HAS3 Gene

HAS3 (Hyaluronan Synthase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include hyaluronan synthase activity. An important paralog of this gene is HAS2.

UniProtKB/Swiss-Prot for HAS3 Gene

  • Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).

Gene Wiki entry for HAS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAS3 Gene

Genomics for HAS3 Gene

Regulatory Elements for HAS3 Gene

Enhancers for HAS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F069048 0.2 ENCODE 11.5 -56.1 -56113 2.1 CTCF MAFG ZNF2 RAD21 ZNF121 ZNF316 JUND NFE2 FOS MAFK RNU6-898P HAS3 CDH1 SNTB2 RPS2P45
GH16F068990 0.9 Ensembl ENCODE 11.4 -111.7 -111687 6.5 ELF3 ARID4B SIN3A RAD21 SLC30A9 FOS MIXL1 CEBPB PPARG RCOR2 UTP4 HAS3 SNTB2 ENSG00000200164 CDH1 FTLP14 NFATC3 GC16M069007 ENSG00000260999
GH16F069039 1.1 Ensembl ENCODE 11.2 -65.3 -65269 2.1 ARID4B SIN3A DMAP1 YY1 GLIS2 FOS SP5 MXD4 PPARG ZNF592 HAS3 NOB1 SNTB2 RPS2P45
GH16F069026 0.4 FANTOM5 11.1 -79.1 -79057 0.1 HAS3 LOC101060098 RNU6-898P
GH16F069031 0.2 ENCODE 11.1 -73.6 -73551 1.1 ELF3 MLX ARID4B RAD21 RARA SCRT2 MIXL1 THAP11 SP5 MXD4 RNU6-898P HAS3 NOB1 RPS2P45 LOC101060098
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HAS3 on UCSC Golden Path with GeneCards custom track

Promoters for HAS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000509297 636 2001 ZFP64 ARID4B SIN3A FEZF1 ZNF2 GLIS2 SP3 TSHZ1 REST ZNF623

Genomic Location for HAS3 Gene

Chromosome:
16
Start:
69,105,564 bp from pter
End:
69,118,719 bp from pter
Size:
13,156 bases
Orientation:
Plus strand

Genomic View for HAS3 Gene

Genes around HAS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAS3 Gene

Proteins for HAS3 Gene

  • Protein details for HAS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00219-HYAS3_HUMAN
    Recommended name:
    Hyaluronan synthase 3
    Protein Accession:
    O00219
    Secondary Accessions:
    • A8K5T5
    • Q8WTZ0
    • Q9NYP0

    Protein attributes for HAS3 Gene

    Size:
    553 amino acids
    Molecular mass:
    62998 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HAS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAS3 Gene

Post-translational modifications for HAS3 Gene

  • Glycosylation at Asn 462
  • Modification sites at PhosphoSitePlus

Other Protein References for HAS3 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for HAS3

No data available for DME Specific Peptides for HAS3 Gene

Domains & Families for HAS3 Gene

Gene Families for HAS3 Gene

Protein Domains for HAS3 Gene

Suggested Antigen Peptide Sequences for HAS3 Gene

Graphical View of Domain Structure for InterPro Entry

O00219

UniProtKB/Swiss-Prot:

HYAS3_HUMAN :
  • Belongs to the NodC/HAS family.
Family:
  • Belongs to the NodC/HAS family.
genes like me logo Genes that share domains with HAS3: view

Function for HAS3 Gene

Molecular function for HAS3 Gene

GENATLAS Biochemistry:
hyaluronan synthase gene 3,63.3kDa
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).
UniProtKB/Swiss-Prot Function:
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).

Enzyme Numbers (IUBMB) for HAS3 Gene

Gene Ontology (GO) - Molecular Function for HAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0050501 hyaluronan synthase activity IDA,TAS --
genes like me logo Genes that share ontologies with HAS3: view
genes like me logo Genes that share phenotypes with HAS3: view

Animal Models for HAS3 Gene

MGI Knock Outs for HAS3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HAS3 Gene

Localization for HAS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAS3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAS3 Gene COMPARTMENTS Subcellular localization image for HAS3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for HAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9169154
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 9083017
genes like me logo Genes that share ontologies with HAS3: view

Pathways & Interactions for HAS3 Gene

genes like me logo Genes that share pathways with HAS3: view

UniProtKB/Swiss-Prot O00219-HYAS3_HUMAN

  • Pathway: Glycan biosynthesis; hyaluronan biosynthesis.

Gene Ontology (GO) - Biological Process for HAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 9169154
GO:0007155 cell adhesion IBA --
GO:0030213 hyaluronan biosynthetic process IDA,TAS --
GO:0045226 extracellular polysaccharide biosynthetic process ISS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 16900089
genes like me logo Genes that share ontologies with HAS3: view

No data available for SIGNOR curated interactions for HAS3 Gene

Drugs & Compounds for HAS3 Gene

(8) Drugs for HAS3 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma 439
UDP-alpha-D-glucuronic acid Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0
anthracyclines and related substances Pharma 0
Magnesium Nutra 0

(5) Additional Compounds for HAS3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
528-04-1
genes like me logo Genes that share compounds with HAS3: view

Transcripts for HAS3 Gene

Unigene Clusters for HAS3 Gene

Hyaluronan synthase 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAS3 Gene

No ASD Table

Relevant External Links for HAS3 Gene

GeneLoc Exon Structure for
HAS3
ECgene alternative splicing isoforms for
HAS3

Expression for HAS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HAS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAS3 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.9), Minor Salivary Gland (x8.5), and Bladder (x4.3).

Protein differential expression in normal tissues from HIPED for HAS3 Gene

This gene is overexpressed in Adrenal (36.8) and Urine (32.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HAS3 Gene



Protein tissue co-expression partners for HAS3 Gene

NURSA nuclear receptor signaling pathways regulating expression of HAS3 Gene:

HAS3

SOURCE GeneReport for Unigene cluster for HAS3 Gene:

Hs.592069
genes like me logo Genes that share expression patterns with HAS3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HAS3 Gene

Orthologs for HAS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HAS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAS3 34 35
  • 99.64 (n)
oppossum
(Monodelphis domestica)
Mammalia HAS3 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAS3 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HAS3 34 35
  • 93.13 (n)
dog
(Canis familiaris)
Mammalia HAS3 34 35
  • 92.77 (n)
rat
(Rattus norvegicus)
Mammalia Has3 34
  • 90.6 (n)
mouse
(Mus musculus)
Mammalia Has3 34 16 35
  • 90.24 (n)
chicken
(Gallus gallus)
Aves HAS3 34 35
  • 82.36 (n)
lizard
(Anolis carolinensis)
Reptilia HAS3 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia has3 34
  • 72.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC399037 34
zebrafish
(Danio rerio)
Actinopterygii has3 34 35
  • 72.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHS3 37
Species where no ortholog for HAS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAS3 Gene

ENSEMBL:
Gene Tree for HAS3 (if available)
TreeFam:
Gene Tree for HAS3 (if available)

Paralogs for HAS3 Gene

Paralogs for HAS3 Gene

(2) SIMAP similar genes for HAS3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HAS3 Gene

genes like me logo Genes that share paralogs with HAS3: view

Variants for HAS3 Gene

Sequence variations from dbSNP and Humsavar for HAS3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2232228 drug-response 69,109,674(+) GCCGC(A/G)TACCA reference, synonymous-codon
rs147999236 Uncertain significance 69,109,536(+) GGCCT(C/G/T)TACGG reference, synonymous-codon
rs10558208 -- 69,117,577(+) CCTGC(-/T)TTTTT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1077518 -- 69,109,129(-) tgggc(G/T)acaca intron-variant
rs1110548 -- 69,104,985(-) AAAAA(A/C)CAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HAS3 Gene

Variant ID Type Subtype PubMed ID
nsv833268 CNV loss 17160897

Variation tolerance for HAS3 Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAS3 Gene

Disorders for HAS3 Gene

Relevant External Links for HAS3

Genetic Association Database (GAD)
HAS3
Human Genome Epidemiology (HuGE) Navigator
HAS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAS3

No disorders were found for HAS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAS3 Gene

Publications for HAS3 Gene

  1. Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase. (PMID: 9083017) Spicer A.P. … McDonald J.A. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening. (PMID: 18587729) Nair S. … Bowen T. (J. Nephrol. 2008) 3 22 46 64
  3. Chromosomal localization of the human and mouse hyaluronan synthase genes. (PMID: 9169154) Spicer A.P. … McDonald J.A. (Genomics 1997) 2 3 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity. (PMID: 19231585) Dunn K.M. … McCarthy J.B. (Surgery 2009) 3 22 64

Products for HAS3 Gene

Sources for HAS3 Gene

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