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Aliases for HAS3 Gene

Aliases for HAS3 Gene

  • Hyaluronan Synthase 3 2 3
  • Hyaluronic Acid Synthase 3 4
  • Hyaluronate Synthase 3 4
  • HA Synthase 3 4
  • EC 2.4.1.212 4

External Ids for HAS3 Gene

Summaries for HAS3 Gene

Entrez Gene Summary for HAS3 Gene

  • The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for HAS3 Gene

HAS3 (Hyaluronan Synthase 3) is a Protein Coding gene. Diseases associated with HAS3 include nodular basal cell carcinoma and juvenile hyaline fibromatosis. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include hyaluronan synthase activity. An important paralog of this gene is HAS1.

UniProtKB/Swiss-Prot for HAS3 Gene

  • Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).

Gene Wiki entry for HAS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAS3 Gene

Genomics for HAS3 Gene

Genomic Location for HAS3 Gene

Start:
69,105,564 bp from pter
End:
69,118,719 bp from pter
Size:
13,156 bases
Orientation:
Plus strand

Genomic View for HAS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAS3 Gene

Regulatory Elements for HAS3 Gene

Proteins for HAS3 Gene

  • Protein details for HAS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00219-HYAS3_HUMAN
    Recommended name:
    Hyaluronan synthase 3
    Protein Accession:
    O00219
    Secondary Accessions:
    • A8K5T5
    • Q8WTZ0
    • Q9NYP0

    Protein attributes for HAS3 Gene

    Size:
    553 amino acids
    Molecular mass:
    62998 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HAS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAS3 Gene

Proteomics data for HAS3 Gene at MOPED

Post-translational modifications for HAS3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn462

Other Protein References for HAS3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HAS3 Gene

Domains for HAS3 Gene

Gene Families for HAS3 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Protein Domains for HAS3 Gene

Suggested Antigen Peptide Sequences for HAS3 Gene

Graphical View of Domain Structure for InterPro Entry

O00219

UniProtKB/Swiss-Prot:

HYAS3_HUMAN
Family:
  • Belongs to the NodC/HAS family.:
    • O00219
genes like me logo Genes that share domains with HAS3: view

Function for HAS3 Gene

Molecular function for HAS3 Gene

GENATLAS Biochemistry: hyaluronan synthase gene 3,63.3kDa
UniProtKB/Swiss-Prot CatalyticActivity: UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan)
UniProtKB/Swiss-Prot CatalyticActivity: UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)
UniProtKB/Swiss-Prot Function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).

Enzyme Numbers (IUBMB) for HAS3 Gene

Gene Ontology (GO) - Molecular Function for HAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050501 hyaluronan synthase activity IDA 16900089
genes like me logo Genes that share ontologies with HAS3: view

Phenotypes for HAS3 Gene

genes like me logo Genes that share phenotypes with HAS3: view

Animal Models for HAS3 Gene

MGI Knock Outs for HAS3:

miRNA for HAS3 Gene

miRTarBase miRNAs that target HAS3

No data available for Transcription Factor Targeting and HOMER Transcription for HAS3 Gene

Localization for HAS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAS3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAS3 Gene COMPARTMENTS Subcellular localization image for HAS3 gene
Compartment Confidence
extracellular 5
plasma membrane 4
golgi apparatus 2
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9169154
GO:0016021 integral component of membrane TAS 9083017
GO:0036117 hyaluranon cable IDA 16900089
genes like me logo Genes that share ontologies with HAS3: view

Pathways for HAS3 Gene

genes like me logo Genes that share pathways with HAS3: view

Pathways by source for HAS3 Gene

UniProtKB/Swiss-Prot O00219-HYAS3_HUMAN

  • Pathway: Glycan biosynthesis; hyaluronan biosynthesis

Gene Ontology (GO) - Biological Process for HAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0007155 cell adhesion IBA --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030212 hyaluronan metabolic process TAS --
GO:0030213 hyaluronan biosynthetic process TAS --
genes like me logo Genes that share ontologies with HAS3: view

Compounds for HAS3 Gene

(6) HMDB Compounds for HAS3 Gene

Compound Synonyms Cas Number PubMed IDs
Hyaluronan
  • hyaluronic acid
9004-61-9
Hyaluronic acid
  • hyaluronic acid
9004-61-9
Magnesium
  • Magnesium
7439-95-4
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate glucuronic acid
  • UDP glucuronate
2616-64-0

(8) Novoseek inferred chemical compound relationships for HAS3 Gene

Compound -log(P) Hits PubMed IDs
glycosaminoglycan 77.4 1
hyaluronic acid 67.3 5
n-acetylglucosamine 26.6 1
hydrocortisone 23.7 2
agarose 22.1 1

(1) PharmGKB related drug/compound annotations for HAS3 Gene

Drug/compound Annotation
anthracyclines and related substances CA
genes like me logo Genes that share compounds with HAS3: view

Transcripts for HAS3 Gene

Unigene Clusters for HAS3 Gene

Hyaluronan synthase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAS3 Gene

No ASD Table

Relevant External Links for HAS3 Gene

GeneLoc Exon Structure for
HAS3
ECgene alternative splicing isoforms for
HAS3

Expression for HAS3 Gene

mRNA expression in normal human tissues for HAS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAS3 Gene

This gene is overexpressed in Esophagus - Mucosa (9.9), Minor Salivary Gland (8.5), and Bladder (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HAS3 Gene

SOURCE GeneReport for Unigene cluster for HAS3 Gene Hs.592069

genes like me logo Genes that share expressions with HAS3: view

No data available for mRNA Expression by UniProt/SwissProt for HAS3 Gene

Orthologs for HAS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HAS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAS3 35
  • 99.64 (n)
  • 100 (a)
HAS3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HAS3 35
  • 93.13 (n)
  • 98.92 (a)
HAS3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAS3 35
  • 92.77 (n)
  • 98.73 (a)
HAS3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Has3 35
  • 90.24 (n)
  • 97.11 (a)
Has3 16
Has3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HAS3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAS3 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Has3 35
  • 90.6 (n)
  • 97.65 (a)
chicken
(Gallus gallus)
Aves HAS3 35
  • 82.36 (n)
  • 86.31 (a)
HAS3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HAS3 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC399037 35
tropical clawed frog
(Silurana tropicalis)
Amphibia has3 35
  • 72.07 (n)
  • 81.22 (a)
zebrafish
(Danio rerio)
Actinopterygii has3 35
  • 72.03 (n)
  • 77.11 (a)
has3 36
  • 76 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHS3 38
Species with no ortholog for HAS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAS3 Gene

ENSEMBL:
Gene Tree for HAS3 (if available)
TreeFam:
Gene Tree for HAS3 (if available)

Paralogs for HAS3 Gene

Paralogs for HAS3 Gene

Selected SIMAP similar genes for HAS3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HAS3 Gene

genes like me logo Genes that share paralogs with HAS3: view

Variants for HAS3 Gene

Sequence variations from dbSNP and Humsavar for HAS3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1077518 -- 69,109,129(-) tgggc(G/T)acaca intron-variant
rs1110548 -- 69,104,985(-) AAAAA(A/C)CAGAG upstream-variant-2KB
rs2232226 -- 69,109,241(+) cagta(G/T)tctgg intron-variant
rs2232227 -- 69,109,578(+) AGCCT(G/T)TTTGC synonymous-codon, reference
rs2232228 -- 69,109,674(+) GCCGC(A/G)TACCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HAS3 Gene

Variant ID Type Subtype PubMed ID
nsv833268 CNV Loss 17160897
nsv906819 CNV Loss 21882294

Relevant External Links for HAS3 Gene

HapMap Linkage Disequilibrium report
HAS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAS3 Gene

Disorders for HAS3 Gene

(1) University of Copenhagen DISEASES for HAS3 Gene

(10) Novoseek inferred disease relationships for HAS3 Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 38.9 5
mesothelioma 24.5 2
tumors 23.7 5
ovarian cancer 21.8 1
prostate cancer 20.7 3

Relevant External Links for HAS3

Genetic Association Database (GAD)
HAS3
Human Genome Epidemiology (HuGE) Navigator
HAS3
genes like me logo Genes that share disorders with HAS3: view

No data available for UniProtKB/Swiss-Prot for HAS3 Gene

Publications for HAS3 Gene

  1. Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase. (PMID: 9083017) Spicer A.P. … McDonald J.A. (J. Biol. Chem. 1997) 2 3 4 23
  2. Chromosomal localization of the human and mouse hyaluronan synthase genes. (PMID: 9169154) Spicer A.P. … McDonald J.A. (Genomics 1997) 2 3 23
  3. Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening. (PMID: 18587729) Nair S. … Bowen T. (J. Nephrol. 2008) 3 23 48
  4. Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity. (PMID: 19231585) Dunn K.M. … McCarthy J.B. (Surgery 2009) 3 23
  5. Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells. (PMID: 16900089) Selbi W. … Phillips A.O. (Kidney Int. 2006) 3 23

Products for HAS3 Gene

Sources for HAS3 Gene

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