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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HAS3 Gene

protein-coding GIFtS: 56
GCID: GC16P069140

hyaluronan synthase 3

Explore 31 diseases affiliated with
HAS3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hyaluronan Synthase 3¹ ²
Hyaluronate Synthase 3² ³
Hyaluronic Acid Synthase 3² ³
HA Synthase 3² ³
EC 2.4.1.212³ ⁸

External Ids:	HGNC: 4820¹	Entrez Gene: 3038²	Ensembl: ENSG00000103044⁷	OMIM: 602428⁵	UniProtKB: O00219³

Export aliases for HAS3 gene to outside databases

Previous GC identifers: GC16P059825 GC16P069517 GC16P068875 GC16P068916 GC16P067697 GC16P055012

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HAS3:

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or

hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene

family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a

regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. (provided by RefSeq,

Dec 2010)

UniProtKB/Swiss-Prot: HAS3_HUMAN, O00219

Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis

Gene Wiki entry for HAS3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HAS3 gene promoter:
RORalpha1 HEN1 AP-2beta Nkx2-5 AP-2alpha AP-2alphaA
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for HAS3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAS3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1

HAS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAS3 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P069140: view genomic region (about GC identifiers)

Start:	69,139,467 bp from pter	End:	69,152,622 bp from pter
Size:	13,156 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HAS3_HUMAN, O00219 (See protein sequence)

Recommended Name: Hyaluronan synthase 3

Size: 553 amino acids; 62998 Da

Cofactor: Magnesium

Subcellular location: Membrane; Multi-pass membrane protein (Probable)

Secondary accessions: A8K5T5 Q8WTZ0 Q9NYP0

Alternative splicing: 2 isoforms: O00219-1 O00219-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HAS3: NX_O00219

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00219

4/18 DME Specific Peptides for HAS3 (O00219) (see all 18)

QVCDSDT

DYLRKCL

TKYTARS

LLQQFLE

HAS3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001186209.1 NP_005320.2 NP_619515.1

ENSEMBL proteins:

ENSP00000454731 ENSP00000219322 ENSP00000456246 ENSP00000304440

Reactome Protein details: O00219
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): HAS3 OriGene Custom Protein Services for HAS3
	GenScript Custom Purified and Recombinant Proteins Services for HAS3
	Novus Biologicals HAS3 Protein Novus Biologicals HAS3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HAS3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9169154
GO:0016021	integral to membrane	TAS	9083017
GO:0036117	hyaluranon cable	IDA	16900089

HAS3 for ontologies About GeneDecksing

HAS3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HAS3
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HAS3
	GenScript Custom Superior Antibodies Services for HAS3
	Novus Biologicals HAS3 Antibodies
	Search for Antibodies for HAS3 at Abcam
	Uscn Antibodies for HAS3
	Search ThermoFisher Antibodies for HAS3

Assay Products for HAS3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HAS3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HAS3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HAS3 for domains About GeneDecksing

2 InterPro domains/families:

IPR026107 HAS/NodC

IPR026108 HA_synthase_3

Graphical View of Domain Structure for InterPro Entry O00219

ProtoNet protein and cluster: O00219

1 Blocks protein family: IPB001173 Glycosyl transferase

UniProtKB/Swiss-Prot: HAS3_HUMAN, O00219

Similarity: Belongs to the NodC/HAS family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HAS3_HUMAN, O00219

Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis

Catalytic activity: UDP-alpha-N-acetyl-D-glucosamine +

beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP +

N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent

hyaluronan)

Catalytic activity: UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent

hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent

hyaluronan)

Genatlas biochemistry entry for HAS3:

hyaluronan synthase gene 3,63.3kDa

Enzyme Number (IUBMB): EC 2.4.1.212¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HAS3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAS3
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate HAS3 (see all 49):
		hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-29a hsa-miR-1260b hsa-miR-25 hsa-miR-219-5p hsa-miR-4325 hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmid: HAS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAS3 (see all 7) OriGene shRNA RFP: HAS3 OriGene siRNA: HAS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAS3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HAS3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAS3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAS3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): HAS3 (NM_005329)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HAS3
		Search LifeMap BioReagents cell lines for HAS3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0050501	hyaluronan synthase activity	IDA	16900089

HAS3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for HAS3:

Increased circadian period len

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Has3^tm1Daq for HAS3
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Has3):

respiratory system

HAS3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/14 pathways (see all 14)
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS I - Hurler syndrome	1.00	MPS IIID - Sanfilippo syndrome D	1.00
Mucopolysaccharidoses	1.00	MPS IX - Natowicz syndrome	1.00
MPS IV - Morquio syndrome A	1.00	MPS II - Hunter syndrome	1.00

HAS1,2,3 mediate the polymerisation of HA

HAS1,2,3 mediate the polymerisation of HA

1.00

Hyaluronan biosynthesis and export

0.75

Disease

Disease

1.00

Metabolism

Metabolism

1.00

Hyaluronan uptake and degradation

Hyaluronan metabolism

0.71

Pathway sources
See GeneCards unified pathways
Show all pathways

5/19 Reactome Pathways for HAS3 (see all 19)

	Hyaluronan metabolism
	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	MPS II - Hunter syndrome

UniProtKB/Swiss-Prot: HAS3_HUMAN, O00219

Pathway: Glycan biosynthesis; hyaluronan biosynthesis

HAS3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HAS3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for HAS3 (O00219³ ENSP00000304440⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HAS2	Q92819³, ENSP00000306991⁴	I2D: score=1 STRING: ENSP00000306991
ABCC5	ENSP00000333926⁴	STRING: ENSP00000333926
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0030203	glycosaminoglycan metabolic process	TAS	--
GO:0030212	hyaluronan metabolic process	TAS	--
GO:0030213	hyaluronan biosynthetic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

HAS3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HAS3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HAS3

6 HMDB Compounds for HAS3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Hyaluronan	hyaluronic acid (see all 13)	9004-61-9	--
Hyaluronic acid	hyaluronic acid	9004-61-9	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Uridine 5'-diphosphate	5'-UDP (see all 9)	58-98-0	--
Uridine diphosphate glucuronic acid	UDP glucuronate (see all 41)	2616-64-0	--
Uridine diphosphate-N-acetylglucosamine	N-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)	528-04-1	--

8 Novoseek chemical compound relationships for HAS3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycosaminoglycan	77.4	2	12757764 (1)
hyaluronic acid	67.3	10	11470161 (2), 17230515 (1), 18199543 (1), 19559501 (1)
n-acetylglucosamine	26.6	1	14976384 (1)
hydrocortisone	23.7	2	10794710 (1), 13130151 (1)
agarose	22.1	1	10772242 (1)
dexamethasone	8.41	1	13130151 (1)
retinoic acid	1.42	5	10772242 (3), 14976384 (1)
tyrosine	0	1	15905585 (1)

Search CenterWatch for drugs/clinical trials and news about HAS3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HAS3 gene (3 alternative transcripts):

NM_001199280.1 NM_005329.2 NM_138612.2

Unigene Cluster for HAS3:

Hyaluronan synthase 3

Hs.592069 [show with all ESTs]

Unigene Representative Sequence: NM_001199280

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000569188 ENST00000568321 ENST00000219322(uc002ewk.3) ENST00000566118(uc010vlk.1)

ENST00000306560(uc010cfh.3 uc002ewl.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HAS3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAS3
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate HAS3 (see all 49):
		hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-29a hsa-miR-1260b hsa-miR-25 hsa-miR-219-5p hsa-miR-4325 hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmid: HAS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAS3 (see all 7) OriGene shRNA RFP: HAS3 OriGene siRNA: HAS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAS3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAS3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAS3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): HAS3 (NM_005329)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS3

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAS3

Additional cDNA sequence:

AF232772.1 AF234839.1 AK291400.1 BC021853.1 FJ648810.1 FJ648811.1

5 DOTS entries:

DT.110342 DT.97819483 DT.120681185 DT.99930199 DT.100822682

24/64 AceView cDNA sequences (see all 64):

BC021853 AW294351 CA487249 CN482851 AA453764 BX372373 BG284710 NM_005329

NM_138612 AW157739 AA493783 BE047664 CA439350 BX385324 BM544036 AI338972

AI982787 AF234839 AI400269 BE550552 AI970624 AW081535 AA227919 BE217826

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HAS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGCTGGAA

About this image

HAS3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Autopod

Prechondrocytic Mesenchymal Cells

Selective marker (cell-identifying gene)

Bone, Cartilage

Limb

Autopod Synovial Joint

Central Intermediate Lamina Cells

Cartilage

Limb

Autopod Synovial Joint

Interzone Cells

Cartilage

Limb

Stylopod

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Limb

Stylopod Synovial Joint

Central Intermediate Lamina Cells

Cartilage

Limb

Stylopod Synovial Joint

Interzone Cells

Cartilage

Limb

Zeugopod

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Limb

Zeugopod Synovial Joint

Central Intermediate Lamina Cells

Cartilage

Limb

Zeugopod Synovial Joint

Interzone Cells

Cartilage

Kidney

S-shaped Body

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See HAS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HAS3

SOURCE GeneReport for Unigene cluster: Hs.592069

SABiosciences Custom PCR Arrays for HAS3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAS3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HAS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAS3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HAS3 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HAS3¹	hyaluronan synthase 3	82.36(n) 86.31(a)		427564 XM_425137.3 XP_425137.3
lizard (Anolis carolinensis)	Reptilia	HAS3⁶	--	80(a)	1 ↔ 1	GL343914.1(15612-21115)
African clawed frog (Xenopus laevis)	Amphibia	LOC399037²	hyaluronic acid synthase 3	74.4(n)		AY302252.1
zebrafish (Danio rerio)	Actinopterygii	has3¹	hyaluronan synthase 3	71.79(n) 76.92(a)		282555 NM_173220.1 NP_775327.1

ENSEMBL Gene Tree for HAS3 (if available)
TreeFam Gene Tree for HAS3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HAS3 gene

HAS1² HAS2²

2 SIMAP similar genes for HAS3 using alignment to 4 protein entries: HAS3_HUMAN (see all proteins):

HAS2 HAS1

HAS3 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for HAS3
PGOHUM00000241256

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61633680^1,2	C,	--	69137729(+)	`CTGAGC/TGCTTA`	1	--	us2k¹		2		WA	120
rs182621858^1,2		--	69137730(+)	`TGAGCA/GCTTAC`	1	--	us2k¹		0	--	--	--	--
rs186553022^1,2		--	69137751(+)	`TCTCTG/TCAAAC`	1	--	us2k¹		0	--	--	--	--
rs140424573^1,2		--	69137791(+)	`TGTGGA/GATGAA`	1	--	us2k¹		0	--	--	--	--
rs142734129^1,2		--	69137806(+)	`CTGGGC/GCTTAC`	1	--	us2k¹		0	--	--	--	--
rs192376762^1,2		--	69137824(+)	`CTCTAC/GAGCCC`	1	--	us2k¹		0	--	--	--	--
rs117046385^1,2	C,F,	--	69137925(+)	`ACATTG/AGCAGC`	1	--	us2k¹		2		NA EA	240
rs114257005^1,2	F,	--	69137954(+)	`TATAGG/TACTAG`	1	--	us2k¹		1		WA	118
rs183885228^1,2		--	69138239(+)	`CTGTCA/GCCCAG`	2	--	us2k¹		0	--	--	--	--
rs117337537^1,2	C,F,	--	69138272(+)	`TTGGCC/TCACTG`	2	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for HAS3 (69139467 - 69152622 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HAS3: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HAS3 for disorders           About GeneDecksing

OMIM gene information: 602428    OMIM disorders: --

20/31 diseases for HAS3 (see all 31):    About MalaCards

juvenile hyaline fibromatosis attention deficit hyperactivity disorder nodular basal cell carcinoma basal cell carcinoma

gingival overgrowth fibromatosis rheumatoid arthritis malignant mesothelioma

squamous cell carcinoma colon carcinoma graves' disease gingivitis

acne ovarian cancer carcinoma endometrial carcinoma

nephropathy arthritis prostate cancer fibrosarcoma

10 Novoseek disease relationships for HAS3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	38.9	7	14566823 (4), 19231585 (1)
mesothelioma	24.5	2	10794710 (1), 15731923 (1)
tumors	23.7	9	15763928 (1), 17315194 (1), 19218337 (1), 20106115 (1) (see all 5)
ovarian cancer	21.8	1	15375493 (1)
prostate cancer	20.7	3	11431361 (2), 16816377 (1)
metastasis	16.9	5	19218337 (1), 14566823 (1)
rheumatoid arthritis	10.4	1	15763928 (1)
necrosis	3.45	1	15763928 (1)
primary tumor	0	1	14566823 (1)
cancer	0	1	14566823 (1)

Human Genome Epidemiology (HuGE) Navigator: HAS3 (4 documents)

Export disorders for HAS3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HAS3 gene, integrated from 9 sources (see all 89):
(articles sorted by number of sources associating them with HAS3)

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Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase. (PubMed id 9083017)^{1, 2, 3, 9} Spicer A.P.... McDonald J.A. (1997)
Chromosomal localization of the human and mouse hyaluronan synthase genes. (PubMed id 9169154)^{1, 3, 9} Spicer A.P....McDonald J.A. (1997)
Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth. (PubMed id 14566823)^{1, 9} Bullard K.M....McCarthy J.B. (2003)
Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells. (PubMed id 11431361)^{1, 9} Liu N.... Zhang L. (2001)
Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes. (PubMed id 11851874)^{1, 9} Sayo T....Inoue S. (2002)
Expression of human hyaluronan synthases in response to external stimuli. (PubMed id 10794710)^{1, 9} Jacobson A....Heldin P. (2000)
Expression of hyaluronan synthases (HAS1-3) and hyalu ronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between H YAL1 and hyaluronan content. (PubMed id 19435493)^{1, 9} Nykopp T.K....Anttila M. (2009)
Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening. (PubMed id 18587729)^{1, 9} Nair S....Bowen T. (2008)
Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells. (PubMed id 16900089)^{1, 9} Selbi W....Phillips A.O. (2006)
Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells. (PubMed id 11790779)^{1, 9} Simpson M.A....McCarthy J.B. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3038	HGNC: 4820	AceView: HAS3	Ensembl:ENSG00000103044	euGenes: HUgn3038
ECgene: HAS3	H-InvDB: HAS3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HAS3	Pharmacogenomics, SNPs, Pathways
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/

Intellectual Property for HAS3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HAS3 gene:
Search GeneIP for patents involving HAS3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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