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HAS3 Gene

protein-coding   GIFtS: 62
GCID: GC16P069140

Hyaluronan Synthase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hyaluronan Synthase 31 2
Hyaluronate Synthase 32 3
Hyaluronic Acid Synthase 32 3
HA Synthase 32 3
EC 2.4.1.2123

External Ids:    HGNC: 48201   Entrez Gene: 30382   Ensembl: ENSG000001030447   OMIM: 6024285   UniProtKB: O002193   

Export aliases for HAS3 gene to outside databases

Previous GC identifers: GC16P059825 GC16P069517 GC16P068875 GC16P068916 GC16P067697 GC16P055012


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAS3 Gene:
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or
hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS
gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be
more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Dec 2010)

GeneCards Summary for HAS3 Gene:
HAS3 (hyaluronan synthase 3) is a protein-coding gene. Diseases associated with HAS3 include juvenile hyaline fibromatosis, and nodular basal cell carcinoma. GO annotations related to this gene include hyaluronan synthase activity. An important paralog of this gene is HAS1.

UniProtKB/Swiss-Prot: HYAS3_HUMAN, O00219
Function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore,
it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural
role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the
isozymes catalyzing that reaction (By similarity)

Gene Wiki entry for HAS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAS3 gene promoter:
         RORalpha1   HEN1   AP-2beta   Nkx2-5   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HAS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

HAS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAS3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P069140:  view genomic region     (about GC identifiers)

Start:
69,139,467 bp from pter      End:
69,152,622 bp from pter
Size:
13,156 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HYAS3_HUMAN, O00219 (See protein sequence)
Recommended Name: Hyaluronan synthase 3  
Size: 553 amino acids; 62998 Da
Cofactor: Magnesium
Secondary accessions: A8K5T5 Q8WTZ0 Q9NYP0
Alternative splicing: 2 isoforms:  O00219-1   O00219-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HAS3: NX_O00219

Explore proteomics data for HAS3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn462
  • Modification sites at PhosphoSitePlus

  • See HAS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186209.1  NP_005320.2  NP_619515.1  

    ENSEMBL proteins: 
     ENSP00000454731   ENSP00000219322   ENSP00000456246   ENSP00000304440  
    Reactome Protein details: O00219

    HAS3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HAS3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HAS3
    GenScript Custom Purified and Recombinant Proteins Services for HAS3
    Novus Biologicals HAS3 Protein
    Novus Biologicals HAS3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HAS3

    HAS3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HAS3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HAS3
    Novus Biologicals HAS3 Antibodies
    Abcam antibodies for HAS3
    Cloud-Clone Corp. Antibodies for HAS3
    ThermoFisher Antibody for HAS3
    LSBio Antibodies in human, mouse, rat for HAS3

    HAS3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HAS3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HAS3
    Cloud-Clone Corp. CLIAs for HAS3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GLT2: Glycosyltransferase family 2 domain containing

    2 InterPro protein domains:
     IPR026107 HAS/NodC
     IPR026108 HA_synthase_3

    Graphical View of Domain Structure for InterPro Entry O00219

    ProtoNet protein and cluster: O00219

    1 Blocks protein domain: IPB001173 Glycosyl transferase

    UniProtKB/Swiss-Prot: HYAS3_HUMAN, O00219
    Similarity: Belongs to the NodC/HAS family


    HAS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYAS3_HUMAN, O00219
    Function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore,
    it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural
    role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the
    isozymes catalyzing that reaction (By similarity)
    Catalytic activity: UDP-alpha-N-acetyl-D-glucosamine +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP +
    N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent
    hyaluronan)
    Catalytic activity: UDP-alpha-D-glucuronate +
    N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)

         Genatlas biochemistry entry for HAS3:
    hyaluronan synthase gene 3,63.3kDa

         Enzyme Number (IUBMB): EC 2.4.1.2121

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050501hyaluronan synthase activity IDA16900089
         
    HAS3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HAS3:
     Increased circadian period len  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Has3):
     respiratory system 

    HAS3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Has3tm1Daq for HAS3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAS3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HAS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAS3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAS3

    miRNA
    Products:
        
    miRTarBase miRNAs that target HAS3:
    hsa-mir-192-5p (MIRT026580), hsa-mir-215-5p (MIRT024770)

    Block miRNA regulation of human, mouse, rat HAS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HAS3 (see all 49):
    hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-29a hsa-miR-1260b hsa-miR-25 hsa-miR-219-5p hsa-miR-4325 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidHAS3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HAS3
    Predesigned siRNA for gene silencing in human, mouse, rat HAS3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HAS3

    Clone
    Products:
         
    OriGene clones in human, mouse for HAS3 (see all 11)
    OriGene ORF clones in mouse, rat for HAS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HAS3 (NM_005329)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HAS3
    Browse ESI BIO Cell Lines and PureStem Progenitors for HAS3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HYAS3_HUMAN, O00219: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    golgi apparatus2
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9169154
    GO:0016021integral component of membrane TAS9083017
    GO:0036117hyaluranon cable IDA16900089

    HAS3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HAS3 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Metabolism
    Metabolism0.38
    3Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for HAS3
        Hyaluronan biosynthesis and export


    UniProtKB/Swiss-Prot: HYAS3_HUMAN, O00219
    Pathway: Glycan biosynthesis; hyaluronan biosynthesis


    HAS3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HAS3
    Interactions:

        GeneGlobe Interaction Network for HAS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HAS3 (O002193 ENSP000003044404) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAS2Q928193, ENSP000003069914I2D: score=1 STRING: ENSP00000306991
    ABCC5ENSP000003339264STRING: ENSP00000333926
    KYENSP000003975984STRING: ENSP00000397598
    UPF2ENSP000003487084STRING: ENSP00000348708
    EXOC7ENSP000003341004STRING: ENSP00000334100
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030212hyaluronan metabolic process TAS--
    GO:0030213hyaluronan biosynthetic process TAS--
    GO:0044281small molecule metabolic process TAS--

    HAS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HAS3 (HYAS3)

    6 HMDB Compounds for HAS3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronanhyaluronic acid (see all 13)9004-61-9--
    Hyaluronic acidhyaluronic acid 9004-61-9--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--

    8 Novoseek inferred chemical compound relationships for HAS3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycosaminoglycan 77.4 2 12757764 (1)
    hyaluronic acid 67.3 10 11470161 (2), 17230515 (1), 18199543 (1), 19559501 (1)
    n-acetylglucosamine 26.6 1 14976384 (1)
    hydrocortisone 23.7 2 10794710 (1), 13130151 (1)
    agarose 22.1 1 10772242 (1)
    dexamethasone 8.41 1 13130151 (1)
    retinoic acid 1.42 5 10772242 (3), 14976384 (1)
    tyrosine 0 1 15905585 (1)



    HAS3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HAS3 gene (3 alternative transcripts): 
    NM_001199280.1  NM_005329.2  NM_138612.2  

    Unigene Cluster for HAS3:

    Hyaluronan synthase 3
    Hs.592069  [show with all ESTs]
    Unigene Representative Sequence: NM_001199280
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569188 ENST00000568321 ENST00000219322(uc002ewk.3) ENST00000566118(uc010vlk.1)
    ENST00000306560(uc010cfh.3 uc002ewl.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HAS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HAS3 (see all 49):
    hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-29a hsa-miR-1260b hsa-miR-25 hsa-miR-219-5p hsa-miR-4325 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidHAS3 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene ORF clones in mouse, rat for HAS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HAS3 (NM_005329)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HAS3
    OriGene qSTAR qPCR primer pairs in human, mouse for HAS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAS3
      QuantiTect SYBR Green Assays in human, mouse, rat HAS3
      QuantiFast Probe-based Assays in human, mouse, rat HAS3

    Additional mRNA sequence: 

    AF232772.1 AF234839.1 AK291400.1 BC021853.1 FJ648810.1 FJ648811.1 

    4 DOTS entries:

    DT.110342  DT.97819483  DT.120681185  DT.99930199 

    Selected AceView cDNA sequences (see all 64):

    CA487249 BE047664 AW294351 AA453764 BX372373 AW157739 AA493783 NM_138612 
    CN482851 NM_005329 CA439350 BC021853 BG284710 AA287477 AA334964 BM544036 
    BX463935 AA359665 AI970624 AI982787 BX385324 BF114641 AF232772 BE217826 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HAS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGCTGGAA
    HAS3 Expression
    About this image


    HAS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 9 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytic Mesenchymal Cells Stylopod
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             CyT49
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    HAS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HAS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592069
        Custom PCR Arrays for HAS3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HAS3
    OriGene qSTAR qPCR primer pairs in human, mouse for HAS3
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    QuantiTect SYBR Green Assays in human, mouse, rat HAS3
    QuantiFast Probe-based Assays in human, mouse, rat HAS3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HAS3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Has31 , 5 hyaluronan synthase 31, 5 90.24(n)1
    97.11(a)1
      8 (53.28 cM)5
    151181  NM_008217.41  NP_032243.21 
     1068702425 
    chicken
    (Gallus gallus)
    Aves HAS31 hyaluronan synthase 3 82.36(n)
    86.31(a)
      427564  XM_425137.4  XP_425137.4 
    lizard
    (Anolis carolinensis)
    Reptilia HAS36
    hyaluronan synthase 3
    69(a)
    1 ↔ 1
    GL343914.1(11079-25126)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3990372 hyaluronic acid synthase 3 74.4(n)    AY302252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii has31 hyaluronan synthase 3 72.03(n)
    77.11(a)
      282555  NM_173220.1  NP_775327.1 


    ENSEMBL Gene Tree for HAS3 (if available)
    TreeFam Gene Tree for HAS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HAS3 gene
    HAS12  HAS22  
    2 SIMAP similar genes for HAS3 using alignment to 4 protein entries:     HYAS3_HUMAN (see all proteins):
    HAS2    HAS1

    HAS3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HAS3
    PGOHUM00000241256


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HAS3 (see all 282)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs616336801,2
    C,F--69137729(+) CTGAGC/TGCTTA 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs1826218581,2
    --69137730(+) TGAGCA/GCTTAC 1 -- us2k10--------
    rs1865530221,2
    --69137751(+) TCTCTG/TCAAAC 1 -- us2k10--------
    rs1404245731,2
    --69137791(+) TGTGGA/GATGAA 1 -- us2k10--------
    rs1427341291,2
    --69137806(+) CTGGGC/GCTTAC 1 -- us2k10--------
    rs1923767621,2
    --69137824(+) CTCTAC/GAGCCC 1 -- us2k10--------
    rs1170463851,2
    C,F--69137925(+) ACATTG/AGCAGC 1 -- us2k12Minor allele frequency- A:0.04NA EA 240
    rs1142570051,2
    C,F--69137954(+) TATAGG/TACTAG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1838852281,2
    --69138239(+) CTGTCA/GCCCAG 2 -- us2k10--------
    rs1173375371,2
    C,F--69138272(+) TTGGCC/TCACTG 2 -- us2k11Minor allele frequency- T:0.04NA 120

    HapMap Linkage Disequilibrium report for HAS3 (69139467 - 69152622 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HAS3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833268CNV Loss17160897
    nsv906819CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HAS3
    DNA2.0 Custom Variant and Variant Library Synthesis for HAS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602428    OMIM disorders: --

    Selected diseases for HAS3 (see all 31):    
    About MalaCards
    juvenile hyaline fibromatosis    nodular basal cell carcinoma    skin atrophy    morquio syndrome b
    sly syndrome    mucopolysaccharidoses    fibromatosis    basal cell carcinoma
    gingival overgrowth    gingivitis    acne    attention deficit hyperactivity disorder
    malignant mesothelioma    prostate adenocarcinoma    graves' disease    ovarian cancer
    diabetic nephropathy    fibrosarcoma    endometrial carcinoma    periodontitis

    1 disease from the University of Copenhagen DISEASES database for HAS3:
    Skin atrophy

    HAS3 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for HAS3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 38.9 7 14566823 (4), 19231585 (1)
    mesothelioma 24.5 2 10794710 (1), 15731923 (1)
    tumors 23.7 9 15763928 (1), 17315194 (1), 19218337 (1), 20106115 (1) (see all 5)
    ovarian cancer 21.8 1 15375493 (1)
    prostate cancer 20.7 3 11431361 (2), 16816377 (1)
    metastasis 16.9 5 19218337 (1), 14566823 (1)
    rheumatoid arthritis 10.4 1 15763928 (1)
    necrosis 3.45 1 15763928 (1)
    primary tumor 0 1 14566823 (1)
    cancer 0 1 14566823 (1)

    Genetic Association Database (GAD): HAS3
    Human Genome Epidemiology (HuGE) Navigator: HAS3 (4 documents)

    Export disorders for HAS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HAS3 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with HAS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase. (PubMed id 9083017)1, 2, 3, 9 Spicer A.P.... McDonald J.A. (J. Biol. Chem. 1997)
    2. Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening. (PubMed id 18587729)1, 4, 9 Nair S....Bowen T. (J. Nephrol. 2008)
    3. Chromosomal localization of the human and mouse hyaluronan synthase genes. (PubMed id 9169154)1, 3, 9 Spicer A.P....McDonald J.A. (Genomics 1997)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    6. Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth. (PubMed id 14566823)1, 9 Bullard K.M....McCarthy J.B. (Int. J. Cancer 2003)
    7. Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells. (PubMed id 11431361)1, 9 Liu N.... Zhang L. (Cancer Res. 2001)
    8. Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes. (PubMed id 11851874)1, 9 Sayo T....Inoue S. (J. Invest. Dermatol. 2002)
    9. Expression of human hyaluronan synthases in response to external stimuli. (PubMed id 10794710)1, 9 Jacobson A....Heldin P. (Biochem. J. 2000)
    10. Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content. (PubMed id 19435493)1, 9 Nykopp T.K....Anttila M. (BMC Cancer 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3038 HGNC: 4820 AceView: HAS3 Ensembl:ENSG00000103044 euGenes: HUgn3038
    ECgene: HAS3 H-InvDB: HAS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HAS3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=HAS3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HAS3 gene:
    Search GeneIP for patents involving HAS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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