HAS2-AS1 Gene
RNA gene GIFtS: 23
GCID: GC08P122651
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HAS2 antisense RNA 1(Previous names: hyaluronan synthase 2 antisense, HAS2 antisense RNA (non-protein...)
(Previous symbols: HAS2AS, HAS2-AS)
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Aliases
for HAS2-AS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): lncRNA
Quality score for this RNA gene is 3
| Aliases |
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| HAS2 Antisense RNA 11 2 | | NCRNA000771 2 | | HAS2-AS1 2 | | HAS2 Antisense RNA (Non-Protein Coding)1 | | HAS2AS1 2 | | HAS2 Antisense RNA 1 (Non-Protein Coding)1 | | HASNT1 2 | | Hyaluronan Synthase 2 Antisense1 |
| External Ids: | HGNC: 343401 | Entrez Gene: 5948422 | Ensembl: ENSG000002486907 | OMIM: 6143535 | | ORGUL members: | |
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| NONCODE:n380105 n380183 n380015 n405667 | |
Export aliases for HAS2-AS1 gene to outside databases
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Summaries
for HAS2-AS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HAS2-AS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for HAS2-AS1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HAS2-AS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAS2-AS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.13 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24.13HAS2-AS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P122651: view genomic region
(about GC identifiers)
Start:
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122,651,533 bp from pter |
End:
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122,657,565 bp from pter |
Size:
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6,033 bases |
Orientation:
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plus strand |
ORGUL member locations:
Legend (see complete legend)
- n380105
- n380015
- n405667
- n380183
122651532 122654548 122657564 chr8
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Proteins
for HAS2-AS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for HAS2-AS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for HAS2-AS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS2-AS1 |
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Pathways & Interactions
for HAS2-AS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HAS2-AS1
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Drugs & Compounds
for HAS2-AS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for HAS2-AS1
Search CenterWatch for drugs/clinical trials and news about HAS2-AS1 
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Transcripts
for HAS2-AS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for HAS2-AS1: HAS2 antisense RNA 1 Hs.668686 [show with all ESTs]Unigene Representative Sequence: AY9411784 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000518865 ENST00000514180(uc022baf.1) ENST00000522197 ENST00000520043
Additional cDNA sequence: AJ604570.1 AY941178.1 4 DOTS entries: DT.75100243 DT.209587 DT.120637499 DT.120637507
GeneLoc Exon Structure
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Expression
for HAS2-AS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for HAS2-AS1:none
HAS2-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.668686
SABiosciences Custom PCR Arrays for HAS2-AS1
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAS2-AS1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HAS2-AS1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAS2-AS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAS2-AS1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS2-AS1 |
Orthologs
for HAS2-AS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for HAS2-AS1 gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Has2as5 |
HAS2 antisense RNA (non-protein coding) |
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15 (23.34 cM) 56689944 |
ENSEMBL Gene Tree for HAS2-AS1 (if available)
TreeFam Gene Tree for HAS2-AS1 (if available) |
Paralogs
for HAS2-AS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HAS2-AS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for HAS2-AS1 (122651533 - 122657565 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HAS2-AS1: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for HAS2-AS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 HAS2-AS1 for disorders About MalaCards
HAS2-AS1 for disorders About GeneDecksing
OMIM gene information: 614353
OMIM disorders: --
Export disorders for HAS2-AS1 gene to outside databases
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Publications
for HAS2-AS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for HAS2-AS1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HAS2-AS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)1 Yang Q....O'Donnell C.J. (2007)
- Natural antisense mRNAs to hyaluronan synthase 2 inhibit hyaluronan biosynthesis and cell proliferation. (PubMed id 15843373)1 Chao H. and Spicer A.P. (2005)
- Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes. (PubMed id 12186949)9 Rilla K....Tammi R. (2002)
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External Searches for HAS2-AS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing HAS2-AS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing HAS2-AS1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HAS2-AS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HAS2-AS1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for HAS2-AS1 gene:
Search GeneIP for patents involving HAS2-AS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HAS2-AS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HAS2-AS1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HAS2-AS1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAS2-AS1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAS2-AS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAS2-AS1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAS2-AS1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS2-AS1 |
|  |  |  | | | | Search ThermoFisher Antibodies for HAS2-AS1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HAS2-AS1 |
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Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013
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