V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

HAS2 Gene

protein-coding GIFtS: 56

GC08M122694

hyaluronan synthase 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.4.1.212 ^³
MGC126241 ^²
MGC126242 ^²

Descriptions
HA synthase 2 ^³
Hyaluronate synthase 2 ^², ³
Hyaluronic acid synthase 2 ^², ³
hyaluronan synthase 2 ^²

External Ids
HGNC: 4819¹
Entrez Gene: 3037²
UniProtKB: Q92819³
Ensembl: ENSG00000170961⁷

Search outside databases for aliases for HAS2 gene

Previous GC identifers: GC08M121594 GC08M122683 GC08M122294 GC08M122582

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HAS2:

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized

by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular

matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are

linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at

the inner surface of the plasma membrane, and the chains are extruded through pore-like structures

into the extracellular space. It serves a variety of functions, including space filling,

lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively

produced during wound healing and tissue repair to provide a framework for ingrowth of blood

vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory

and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA

with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and

overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the

newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid

sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis,

and human and murine hyaluronan synthase 1. [provided by RefSeq]

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819

Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis

Gene Wiki entry for HAS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HAS2 gene

Entrez Gene cytogenetic band: 8q24.12 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24.12

HAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M122694: (about GC identifiers)

Start:	122,694,719 bp from pter
End:	122,722,811 bp from pter
Size:	28,093 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008046.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819 (See protein sequence)

Recommended Name: Hyaluronan synthase 2

Size: 552 amino acids; 63566 Da

Cofactor: Magnesium

Subcellular location: Membrane; Multi-pass membrane protein (Probable)

Secondary accessions: Q32MM3

REFSEQ proteins: NP_005319.1

ENSEMBL proteins:

ENSP00000306991

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Hyaluronan synthase 2)
	Human Recombinant Proteins from Abnova (HAS2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	9169154
GO:0016020	membrane	IEA	--

About this table

Antibodies for HAS2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Hyaluronan synthase 2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for HAS2

Assays for HAS2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q92819

ProtoNet protein and cluster: Q92819

1 Blocks protein family: IPB001173 Glycosyl transferase

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819

Similarity: Belongs to the nodC/HAS family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAS2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005328

Applied Biosystems Silencer® siRNAs for HAS2

Sigma-Aldrich siRNA and siRNA Panels for HAS2

Sigma-Aldrich shRNA for HAS2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005328
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005328
untagged cDNA clone in CMV expression vector: NM_005328

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005328

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819

Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis

Catalytic activity: UDP-alpha-N-acetyl-D-glucosamine +

beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP +

N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent

hyaluronan)

Catalytic activity: UDP-alpha-D-glucuronate +

N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP +

beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent

hyaluronan)

Enzyme Number (IUBMB): EC 2.4.1.212

Genatlas biochemistry entry for HAS2:

hyaluronan synthase gene 2

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Has2):

	embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
muscle

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016757	transferase activity, transferring glycosyl groups	IEA	--
GO:0050501	hyaluronan synthase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819

Pathway: Glycan biosynthesis; hyaluronan biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for HAS2

5/13 Interacting proteins for HAS2 (ENSP00000306991³) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TGFB1	ENSP00000221930³	STRING (score=.946)
BMP7	ENSP00000360340³	STRING (score=.919)
BMP2	ENSP00000368104³	STRING (score=.886)
SPP1	ENSP00000237623³	STRING (score=.841)
PTGS2	ENSP00000356438³	STRING (score=.791)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HAS2
9 Novoseek chemical compound relationships for HAS2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glycosaminoglycan	77.58	2	12757764 (1)
tgf beta1	43.52	3	16733556 (2)
matrigel	36.01	4	17315194 (1), 19231585 (1)
phosphoinositide	35.44	2	12954618 (1), 17324121 (1)
lipid	0.00	1	19348124 (1)
glucose	0.00	4	16733556 (2), 11318944 (2)
steroid	0.00	1	15317739 (1)
zinc	0.00	1	14757176 (1)
tyrosine	0.00	1	15905585 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAS2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005328

Sigma-Aldrich siRNA and siRNA Panels for HAS2

Sigma-Aldrich shRNA for HAS2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005328

REFSEQ mRNAs for HAS2 gene:

NM_005328.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005328

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005328
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005328
                                 untagged cDNA clone in CMV expression vector: NM_005328

Additional cDNA sequence:

AK297724.1 BC069353.1 BC109071.1 BC109072.1 U54804.1

3 DOTS entries:

DT.209587 DT.204245 DT.120637507

24/35 AceView cDNA sequences (see all 35 ):

BM975166 AW068929 AI079360 BC069353 CA448459 AU280488 AI753259 BE296170

BF941195 AW069182 CD643217 AA579772 AI087079 U54804 AI374739 BF436141

AI769070 W49820 AA742706 AI754826 NM_005328 BX506849 BX956318 AA113093

highest scoring ESTs for HAS2:

U54804 AA113093 AI142961 BC069353 BU621993 BX956318 CD654109 AA334184 AA579772 AI087079

Unigene Cluster for HAS2:

Hyaluronan synthase 2

Hs.159226 [show with all ESTs]

Unigene Representative Sequence: NM_005328

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000303924

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HAS2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HAS2

¹ / ² / ³

3 probe-sets matching HAS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35396_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U54804	1.00	1.00	1.00	1
206432_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005328	0.60	1.00	0.82	1
206432_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAGAAAAGG

SOURCE GeneReport for Unigene cluster: Hs.159226
Expression variation in blood from EXPOLDB for HAS2
UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819
Tissue specificity: Expressed in fibroblasts

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HAS2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HAS2¹	--	hyaluronan synthase 2	93.96(n) 99.46(a)	482032 XM_539153.2 XP_539153.1
chimpanzee (Pan troglodytes)	HAS2¹	--	hyaluronan synthase 2	99.82(n) 100(a)	472850 XM_528222.2 XP_528222.2
cow (Bos taurus)	HAS2¹	--	hyaluronan synthase 2	93.6(n) 98.73(a)	281220 NM_174079.2 NP_776504.1
rat (Rattus norvegicus)	Has2¹	--	hyaluronan synthase 2	91.43(n) 98.37(a)	25694 NM_013153.1 NP_037285.1
mouse (Mus musculus)	Has2^{1, 5}	15 (31.20 cM)⁵	hyaluronan synthase 2^{1, 5}	90.7(n)¹ 98.73(a)¹	15117¹ NM_008216.2¹ NP_032242.2¹ AI122156⁵ AK079729⁵ (see all 10)

About this table Species with no ortholog for HAS2

ENSEMBL Gene Tree for HAS2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HAS2 gene

HAS1² HAS3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/180 NCBI SNPs in HAS2 are shown (see all 180 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 83)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4123220^1,2	A,C,F,H	122723832(+)	`CTTGGT/ACCTTG`	1	--	ng3¹		6		EU WA EA	658
	rs1057308^1,2	A,C,F,H	122722428(+)	`TTTAAG/AAAGGA`	1	--	ut5¹		4		EU EA WA	418
--	rs3853253^1,2	A,C	122722535(+)	`AAAAAA/TTATGC`	1	--	ut5¹		0	--	--	--	--
	rs16895778^1,2	F,H	122694569(+)	`GTTTTG/CTCCAG`	1	--	ut3¹		7		NA EU EA WA	562
--	rs7837322^1,2	A,C	122722537(+)	`AAATTA/TTGCTT`	1	--	ut5¹ ese³		0	--	--	--	--
--	rs3866465^1,2	C	122722583(+)	`tctttC/G/Tttttt`	1	--	ut5¹ trp³		0	--	--	--	--
	rs1057315^1,2	C	122695013(-)	`AAATTC/G/TTGTAT`	1	--	ut3¹		0	--	--	--	--
	rs7831685^1,2	H	122694913(+)	`aatttT/Cttaag`	1	--	ut3¹		4		EU EA WA	402
	rs35375618^1,2	F	122696160(+)	`AGATAT/CTCTAT`	1	E/E	syn¹		1		NA	44
	rs35989566^1,2	F	122696049(+)	`ATAATC/TGCTTC`	1	A/A	syn¹		1		NA	68

About this table

HapMap Linkage Disequilibrium images for HAS2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601636

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819

A chromosomal rearrangement involving HAS2 may be a cause of lipoblastomas, which are

benign tumors resulting from transformation of adipocytes, usually diagnosed in children. 8q12.1

to 8q24.1 intrachromosomal rearrangement with PLAG1

10/15 Novoseek disease relationships for HAS2 gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	50.26	2	19231585 (1)
osteosarcoma	36.97	8	16540432 (3), 15922739 (2), 10861215 (1), 11171074 (1)
tumors	27.57	14	16816377 (2), 17315194 (1), 19218337 (1), 16807238 (1) (see all 8)
metastasis	26.47	4	19218337 (1)
atherosclerosis	17.03	1	14752026 (1)
prostate cancer	11.63	1	16816377 (1)
necrosis	10.73	1	16818886 (1)
inflammation	8.67	1	17234708 (1)
cancer	4.13	2	16540432 (1), 14566823 (1)
ovarian cancer	3.60	1	15375493 (1)

About this table

Human Genome Epidemiology Navigator: HAS2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/130 PubMed articles for HAS2 gene (see all 130 ):

Molecular identification of a putative human hyaluronan synthase. (PubMed id 8798477)^{1, 3, 4} Watanabe K. and Yamaguchi Y. (1996)
Chromosomal localization of the human and mouse hyaluronan synthase genes. (PubMed id 9169154)^{1, 2, 3} Spicer A.P....McDonald J.A. (1997)
PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement. (PubMed id 15642402)^{3, 4} Morerio C.... Panarello C. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. (PubMed id 14752026)^{1, 3} Sussmann M....Fischer J.W. (2004)
Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy. (PubMed id 16807238)^{1, 3} Cook A.C....Tuck A.B. (2006)
Natural antisense mRNAs to hyaluronan synthase 2 inhibit hyaluronan biosynthesis and cell proliferation. (PubMed id 15843373)^{1, 3} Chao H. and Spicer A.P. (2005)
Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells. (PubMed id 17315194)^{1, 3} Li Y....Heldin P. (2007)
Identification and analysis of the promoter region of the human hyaluronan synthase 2 gene. (PubMed id 14988410)^{1, 3} Monslow J....Bowen T. (2004)
Putative role of hyaluronan and its related genes, HAS2 and RHAMM, in human early preimplantation embryogenesis and embryonic stem cell characterization. (PubMed id 17872502)^{1, 3} Choudhary M....Lako M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3037	HGNC: 4819	AceView: HAS2	Ensembl:ENSG00000170961	euGenes: HUgn3037
ECgene: HAS2	H-InvDB: HAS2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for HAS2	Genetics and Cytogenetics in Oncology and Haematology
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/

Licensable Technologies for HAS2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HAS2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HAS2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HAS2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HAS2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HAS2)
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Hyaluronan synthase 2)
	Antibodies (Hyaluronan synthase 2)

Search OriGene for HAS2

Search Tocris compounds for HAS2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for HAS2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
HAS2 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

HAS2 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for HAS2

Summaries
for HAS2

Genomic Location
for HAS2

Proteins
for HAS2

Protein Domains/
Families
for HAS2

Gene Function
for HAS2

Pathways & Interactions
for HAS2

Drugs & Compounds
for HAS2

Transcripts
for HAS2

Expression
for HAS2

Orthologs
for HAS2

Paralogs
for HAS2

SNPs/Variants
for HAS2

Disorders & Mutations
for HAS2

Medical News
for HAS2

Publications
for HAS2

Search for HAS2

Genome Databases showing HAS2

Other Databases showing HAS2

Specialized Databases showing HAS2

Licensable Technologies
for HAS2

Services
for HAS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HAS2 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor HAS2

Summariesfor HAS2

Genomic Locationfor HAS2

Proteinsfor HAS2

Protein Domains/Familiesfor HAS2

Gene Functionfor HAS2

Pathways & Interactionsfor HAS2

Drugs & Compoundsfor HAS2

Transcriptsfor HAS2

Expression for HAS2

Orthologsfor HAS2

Paralogsfor HAS2

SNPs/Variantsfor HAS2

Disorders & Mutationsfor HAS2

Medical Newsfor HAS2

Publicationsfor HAS2

Search for HAS2

Genome Databases showing HAS2

Other Databases showing HAS2

Specialized Databases showing HAS2

Licensable Technologiesfor HAS2

Servicesfor HAS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HAS2

Summaries
for HAS2

Genomic Location
for HAS2

Proteins
for HAS2

Protein Domains/
Families
for HAS2

Gene Function
for HAS2

Pathways & Interactions
for HAS2

Drugs & Compounds
for HAS2

Transcripts
for HAS2

Expression
for HAS2

Orthologs
for HAS2

Paralogs
for HAS2

SNPs/Variants
for HAS2

Disorders & Mutations
for HAS2

Medical News
for HAS2

Publications
for HAS2

Licensable Technologies
for HAS2

Services
for HAS2