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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HAS2 Gene

protein-coding GIFtS: 59
GCID: GC08M122624

hyaluronan synthase 2

Explore 33 diseases affiliated with
HAS2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hyaluronan Synthase 2¹ ²
Hyaluronate Synthase 2² ³
Hyaluronic Acid Synthase 2² ³
HA Synthase 2² ³
EC 2.4.1.212³ ⁸

External Ids:	HGNC: 4819¹	Entrez Gene: 3037²	Ensembl: ENSG00000170961⁷	OMIM: 601636⁵	UniProtKB: Q92819³

Export aliases for HAS2 gene to outside databases

Previous GC identifers: GC08M121594 GC08M122683 GC08M122294 GC08M122582 GC08M122694 GC08M117950

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HAS2:

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety

of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating

glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is

synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded

through pore-like structures into the extracellular space. It serves a variety of functions, including space filling,

lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound

healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum

concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In

addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes,

and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified

vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology

to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819

Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis

Gene Wiki entry for HAS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HAS2 gene promoter:
Egr-3 RFX1 AP-4 XBP-1 Cdc5 HEN1 Ik-2 E2F-1 Cart-1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HAS2 promoter sequence

Search SABiosciences Chromatin IP Primers for HAS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.12 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24.12

HAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAS2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M122624: view genomic region (about GC identifiers)

Start:	122,624,356 bp from pter	End:	122,653,630 bp from pter
Size:	29,275 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819 (See protein sequence)

Recommended Name: Hyaluronan synthase 2

Size: 552 amino acids; 63566 Da

Cofactor: Magnesium

Subcellular location: Membrane; Multi-pass membrane protein (Probable)

Secondary accessions: Q32MM3

Explore the universe of human proteins at neXtProt for HAS2: NX_Q92819

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92819

4/27 DME Specific Peptides for HAS2 (Q92819) (see all 27)

QVCDSDT

DYLRKCL

TKYTARS

LEHRKMK

HAS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005319.1

ENSEMBL proteins:

ENSP00000306991

Reactome Protein details: Q92819
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for HAS2
	Novus Biologicals HAS2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HAS2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005625	soluble fraction	--	--
GO:0005887	integral to plasma membrane	IDA	--

HAS2 for ontologies About GeneDecksing

HAS2 Antibody Products:

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	Search for Antibodies for HAS2 at Abcam
	Uscn Antibodies for HAS2
	ThermoFisher Antibody for HAS2

Assay Products for HAS2:

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	GenScript Custom Assay Services for HAS2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HAS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HAS2 for domains About GeneDecksing

2 InterPro domains/families:

IPR026107 HAS/NodC

IPR004835 Chitin_synth_fng

Graphical View of Domain Structure for InterPro Entry Q92819

ProtoNet protein and cluster: Q92819

1 Blocks protein family: IPB001173 Glycosyl transferase

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819

Similarity: Belongs to the NodC/HAS family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819

Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis

Catalytic activity: UDP-alpha-N-acetyl-D-glucosamine +

beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP +

N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent

hyaluronan)

Catalytic activity: UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent

hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent

hyaluronan)

Genatlas biochemistry entry for HAS2:

hyaluronan synthase gene 2

Enzyme Number (IUBMB): EC 2.4.1.212¹ ²

miRNA Products:		miRTarBase miRNAs that target HAS2: hsa-mir-204 (MIRT005828)

		OriGene 3'-UTR Clone: HAS2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAS2
		8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate HAS2 (see all 51):
		hsa-miR-579 hsa-let-7d hsa-miR-376b hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-519a hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: HAS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAS2 (see all 7) OriGene shRNA RFP: HAS2 OriGene siRNA: HAS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAS2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HAS2

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		GenScript: all cDNA clones in your preferred vector: HAS2 (NM_005328)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HAS2
		Search LifeMap BioReagents cell lines for HAS2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0050501	hyaluronan synthase activity	ISS	--

HAS2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for HAS2: Has2^tm1Jam Has2^tm1.2Nita
     11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Has2):

behavior/neurological	cardiovascular system	embryogenesis	growth/size	homeostasis/metabolism
limbs/digits/tail	mortality/aging	muscle	no phenotypic analysis	normal
skeleton

HAS2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/14 pathways (see all 14)
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS I - Hurler syndrome	1.00	MPS IIID - Sanfilippo syndrome D	1.00
Mucopolysaccharidoses	1.00	MPS IX - Natowicz syndrome	1.00
MPS IV - Morquio syndrome A	1.00	MPS II - Hunter syndrome	1.00

HAS1,2,3 mediate the polymerisation of HA

HAS1,2,3 mediate the polymerisation of HA

1.00

Hyaluronan biosynthesis and export

0.75

Disease

Disease

1.00

Metabolism

Metabolism

1.00

Hyaluronan uptake and degradation

Hyaluronan metabolism

0.71

Pathway sources
See GeneCards unified pathways
Show all pathways

5/19 Reactome Pathways for HAS2 (see all 19)

	Hyaluronan metabolism
	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	MPS II - Hunter syndrome

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819

Pathway: Glycan biosynthesis; hyaluronan biosynthesis

HAS2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HAS2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for HAS2 (Q92819³ ENSP00000306991⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HAS3	O00219³, ENSP00000304440⁴	I2D: score=1 STRING: ENSP00000304440
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001822	kidney development	ISS	--
GO:0008284	positive regulation of cell proliferation	IMP	--
GO:0030213	hyaluronan biosynthetic process	ISS	--
GO:0035810	positive regulation of urine volume	ISS	--
GO:0036120	cellular response to platelet-derived growth factor stimulus	IDA	17324121

HAS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HAS2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HAS2

6 HMDB Compounds for HAS2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Hyaluronan	hyaluronic acid (see all 13)	9004-61-9	--
Hyaluronic acid	hyaluronic acid	9004-61-9	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Uridine 5'-diphosphate	5'-UDP (see all 9)	58-98-0	--
Uridine diphosphate glucuronic acid	UDP glucuronate (see all 41)	2616-64-0	--
Uridine diphosphate-N-acetylglucosamine	N-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)	528-04-1	--

10/19 Novoseek chemical compound relationships for HAS2 gene (see all 19) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycosaminoglycan	77.7	2	12757764 (1)
hyaluronic acid	69.1	31	14752026 (5), 16339488 (3), 11470161 (2), 11991580 (1) (see all 12)
4-methylumbelliferone	65.1	3	19285976 (2), 20332231 (1)
udp glucuronic acid	55.7	2	19737932 (1), 19285976 (1)
iloprost	41.2	4	14752026 (2), 19338584 (1)
tgf beta1	40.4	3	16733556 (2)
matrigel	32.5	4	17315194 (1), 19231585 (1)
phosphoinositide	32.3	2	12954618 (1), 17324121 (1)
pge2	12.2	1	14752026 (1)
hydrocortisone	11.9	1	13130151 (1)

Search CenterWatch for drugs/clinical trials and news about HAS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HAS2 gene:

NM_005328.2

Unigene Cluster for HAS2:

Hyaluronan synthase 2

Hs.159226 [show with all ESTs]

Unigene Representative Sequence: NM_005328

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000303924(uc003yph.2)

miRNA Products:		OriGene 3'-UTR Clone: HAS2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAS2
		8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate HAS2 (see all 51):
		hsa-miR-579 hsa-let-7d hsa-miR-376b hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-519a hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: HAS2 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAS2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAS2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HAS2 (NM_005328)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAS2

Additional cDNA sequence:

AK297724.1 BC069353.1 BC109071.1 BC109072.1 U54804.1

3 DOTS entries:

DT.209587 DT.120637507 DT.204245

24/35 AceView cDNA sequences (see all 35):

BC069353 CA448459 AI079360 AW068929 AU280488 BM975166 AI753259 AI769070

AA742706 AW069182 AI087079 AA579772 BF436141 CD643217 BE296170 BF941195

W49820 AI754826 AI374739 NM_005328 BX506849 U54804 AA113093 CD654109

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HAS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGAAAAGG

About this image

HAS2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Endocardial Cushion

Endocardial Cushion Cells

Selective marker (cell-identifying gene)

Endocardium

Endocardium

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Limb

Autopod Synovial Joint

Central Intermediate Lamina Cells

Cartilage

Limb

Autopod Synovial Joint

Interzone Cells

Cartilage

Limb

Stylopod

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Limb

Stylopod Synovial Joint

Central Intermediate Lamina Cells

Cartilage

Limb

Stylopod Synovial Joint

Interzone Cells

Cartilage

Limb

Zeugopod

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Limb

Zeugopod Synovial Joint

Central Intermediate Lamina Cells

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

Definitive Endoderm (Generation of beta c...)

Mesoderm-like cells (Derivation of cardio...)

Beating cell clusters (Spontaneous differen...)

See HAS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HAS2

SOURCE GeneReport for Unigene cluster: Hs.159226

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819

Tissue specificity: Expressed in fibroblasts

SABiosciences Custom PCR Arrays for HAS2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HAS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HAS2 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HAS2¹	hyaluronan synthase 2	84.78(n) 93.3(a)		395594 NM_204806.1 NP_990137.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	95(a) 86(a)	1 ↔ many 1 ↔ many	GL343269.1(1833639-1847323) AAWZ02037214(1173-1910)
African clawed frog (Xenopus laevis)	Amphibia	Xl.608²	Xenopus laevis hyaluronan synthase 2 (HAS2) mRNA, complete more	79.65(n)		AF168465.1
zebrafish (Danio rerio)	Actinopterygii	has2²	hyaluronan synthase 2	76.28(n)		260350 AF190742.1

ENSEMBL Gene Tree for HAS2 (if available)
TreeFam Gene Tree for HAS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HAS2 gene

HAS1² HAS3²

2 SIMAP similar genes for HAS2 using alignment to 1 protein entry: HAS2_HUMAN:

HAS3 HAS1

HAS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7014290^1,2	C,F,H,	--	122624796(+)	`TATTCC/TGATTG`	1	--	ds500¹		13		NS EA NA WA	1768
rs35228194^1,2	C	--	122625187(+)	`AGTTG-/AAAAAA`	1	--	ds500¹		0	--	--	--	--
rs73708096^1,2	C,	--	122625215(+)	`AACATG/ATTCAA`	1	--	ds500¹		2		WA	120
rs16895776^1,2	C,	--	122625240(+)	`CCAGTA/GAATTC`	1	--	ds500¹		3		NA	142
rs186581467^1,2		--	122625294(+)	`CAAAAC/TTATAC`	1	--	ut3¹		0	--	--	--	--
rs16895778^1,2	C,F,H,	--	122625388(+)	`GTTTTG/CTCCAG`	1	--	ut3¹		8		NA NS EA	682
rs139560614^1,2		--	122625488(+)	`TTCAAC/TGATTT`	1	--	ut3¹		0	--	--	--	--
rs190987282^1,2		--	122625511(+)	`CACACA/GAAAGT`	1	--	ut3¹		0	--	--	--	--
rs182410438^1,2		--	122625633(+)	`TTCAAA/TTTTAA`	1	--	ut3¹		0	--	--	--	--
rs7831685^1,2	C,H,	--	122625732(+)	`AATTTT/CTTAAG`	1	--	ut3¹		6		NS EA WA	522

HapMap Linkage Disequilibrium report for HAS2 (122624356 - 122653630 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HAS2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HAS2 for disorders About GeneDecksing

OMIM gene information: 601636 OMIM disorders: --

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819

Note=A chromosomal aberration involving HAS2 may be a cause of lipoblastomas, which are benign tumors

resulting from transformation of adipocytes, usually diagnosed in children. 8q12.1 to 8q24.1 intrachromosomal

rearrangement with PLAG1

20/33 diseases for HAS2 (see all 33): About MalaCards

rheumatoid arthritis arthropathy arthritis atopic dermatitis

eye disease benign tumors colon carcinoma multiple myeloma

osteoarthritis dermatitis ovarian cancer osteosarcoma

endometrial carcinoma nephropathy prostate cancer breast cancer

copd noma fibrosarcoma endometrial cancer

10/15 Novoseek disease relationships for HAS2 gene (see all 15) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	47.6	2	19231585 (1)
osteosarcoma	38.3	8	16540432 (3), 15922739 (2), 10861215 (1), 11171074 (1)
tumors	28.2	14	16816377 (2), 17315194 (1), 19218337 (1), 16807238 (1) (see all 8)
metastasis	22.5	4	19218337 (1)
atherosclerosis	17.5	1	14752026 (1)
prostate cancer	17.2	1	16816377 (1)
necrosis	13.3	1	16818886 (1)
cancer	10.6	5	19416972 (1), 16540432 (1), 14566823 (1)
ovarian cancer	9.26	1	15375493 (1)
osteoarthritis	8.11	1	15763928 (1)

Human Genome Epidemiology (HuGE) Navigator: HAS2 (2 documents)

Export disorders for HAS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HAS2 gene, integrated from 9 sources (see all 164):
(articles sorted by number of sources associating them with HAS2)

Utopia: connect your pdf to the dynamic
world of online information

Molecular identification of a putative human hyaluronan synthase. (PubMed id 8798477)^{1, 2, 9} Watanabe K. and Yamaguchi Y. (1996)
Chromosomal localization of the human and mouse hyaluronan synthase genes. (PubMed id 9169154)^{1, 3, 9} Spicer A.P....McDonald J.A. (1997)
PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement. (PubMed id 15642402)^{1, 2} Morerio C.... Panarello C. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. (PubMed id 14752026)^{1, 9} Sussmann M....Fischer J.W. (2004)
Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy. (PubMed id 16807238)^{1, 9} Cook A.C....Tuck A.B. (2006)
Natural antisense mRNAs to hyaluronan synthase 2 inhibit hyaluronan biosynthesis and cell proliferation. (PubMed id 15843373)^{1, 9} Chao H. and Spicer A.P. (2005)
Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells. (PubMed id 17315194)^{1, 9} Li Y....Heldin P. (2007)
Identification and analysis of the promoter region of the human hyaluronan synthase 2 gene. (PubMed id 14988410)^{1, 9} Monslow J....Bowen T. (2004)
Putative role of hyaluronan and its related genes, HAS2 and RHAMM, in human early preimplantation embryogenesis and embryonic stem cell characterization. (PubMed id 17872502)^{1, 9} Choudhary M....Lako M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3037	HGNC: 4819	AceView: HAS2	Ensembl:ENSG00000170961	euGenes: HUgn3037
ECgene: HAS2	H-InvDB: HAS2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HAS2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HAS2	Genetics and Cytogenetics in Oncology and Haematology
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/

Intellectual Property for HAS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HAS2 gene:
Search GeneIP for patents involving HAS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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