Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HAS2 Gene

protein-coding   GIFtS: 58
GCID: GC08M122624

Hyaluronan Synthase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Hyaluronan Synthase 21 2
Hyaluronate Synthase 22 3
Hyaluronic Acid Synthase 22 3
HA Synthase 22 3
EC 2.4.1.2123

External Ids:    HGNC: 48191   Entrez Gene: 30372   Ensembl: ENSG000001709617   OMIM: 6016365   UniProtKB: Q928193   

Export aliases for HAS2 gene to outside databases

Previous GC identifers: GC08M121594 GC08M122683 GC08M122294 GC08M122582 GC08M122694 GC08M117950


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HAS2 Gene:
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide
variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of
alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic
bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains
are extruded through pore-like structures into the extracellular space. It serves a variety of functions,
including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is
actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and
fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative
arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44
is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with
tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan
synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from
Xenopus laevis, and human and murine hyaluronan synthase 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for HAS2 Gene:
HAS2 (hyaluronan synthase 2) is a protein-coding gene. Diseases associated with HAS2 include lipoblastoma, and arthropathy. GO annotations related to this gene include hyaluronan synthase activity. An important paralog of this gene is HAS1.

UniProtKB/Swiss-Prot: HYAS2_HUMAN, Q92819
Function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore,
it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural
role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the
isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass
hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial
for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in
early contact inhibition a process which stops cell growth when cells come into contact with each other or the
extracellular matrix (By similarity)

Gene Wiki entry for HAS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAS2 gene promoter:
         Egr-3   RFX1   AP-4   XBP-1   Cdc5   HEN1   Ik-2   E2F-1   Cart-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAS2 promoter sequence
   Search Chromatin IP Primers for HAS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.12   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.12

HAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAS2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M122624:  view genomic region     (about GC identifiers)

Start:
122,624,356 bp from pter      End:
122,653,630 bp from pter
Size:
29,275 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HYAS2_HUMAN, Q92819 (See protein sequence)
Recommended Name: Hyaluronan synthase 2  
Size: 552 amino acids; 63566 Da
Cofactor: Magnesium
Secondary accessions: Q32MM3

Explore the universe of human proteins at neXtProt for HAS2: NX_Q92819

Explore proteomics data for HAS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HAS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005319.1  
    ENSEMBL proteins: 
     ENSP00000306991  
    Reactome Protein details: Q92819

    HAS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HAS2
    GenScript Custom Purified and Recombinant Proteins Services for HAS2
    Novus Biologicals HAS2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HAS2

    HAS2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HAS2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HAS2
    Abcam antibodies for HAS2
    Cloud-Clone Corp. Antibodies for HAS2
    ThermoFisher Antibody for HAS2
    LSBio Antibodies in human, mouse, rat for HAS2

    HAS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HAS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HAS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HAS2
    Cloud-Clone Corp. CLIAs for HAS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GLT2: Glycosyltransferase family 2 domain containing

    2 InterPro protein domains:
     IPR026107 HAS/NodC
     IPR028371 HAS2

    Graphical View of Domain Structure for InterPro Entry Q92819

    ProtoNet protein and cluster: Q92819

    1 Blocks protein domain: IPB001173 Glycosyl transferase

    UniProtKB/Swiss-Prot: HYAS2_HUMAN, Q92819
    Similarity: Belongs to the NodC/HAS family


    HAS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYAS2_HUMAN, Q92819
    Function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore,
    it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural
    role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the
    isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass
    hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial
    for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in
    early contact inhibition a process which stops cell growth when cells come into contact with each other or the
    extracellular matrix (By similarity)
    Catalytic activity: UDP-alpha-N-acetyl-D-glucosamine +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP +
    N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent
    hyaluronan)
    Catalytic activity: UDP-alpha-D-glucuronate +
    N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)

         Genatlas biochemistry entry for HAS2:
    hyaluronan synthase gene 2

         Enzyme Number (IUBMB): EC 2.4.1.2121

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050501hyaluronan synthase activity ISS--
         
    HAS2 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Has2):
     behavior/neurological  cardiovascular system  craniofacial  embryogenesis  growth/size/body 
     homeostasis/metabolism  limbs/digits/tail  mortality/aging  muscle  no phenotypic analysis 
     normal  skeleton 

    HAS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HAS2: Has2tm1Jam Has2tm1.2Nita

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HAS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HAS2:
    hsa-let-7a-5p (MIRT035534), hsa-mir-204-5p (MIRT005828)

    Block miRNA regulation of human, mouse, rat HAS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HAS2 (see all 51):
    hsa-miR-579 hsa-let-7d hsa-miR-376b hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-519a hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidHAS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HAS2
    Predesigned siRNA for gene silencing in human, mouse, rat HAS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HAS2

    Clone
    Products:
         
    OriGene clones in human, mouse for HAS2 (see all 7)
    OriGene ORF clones in mouse, rat for HAS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HAS2 (NM_005328)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HAS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for HAS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HYAS2_HUMAN, Q92819: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    golgi apparatus2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IDA--

    HAS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HAS2 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Metabolism
    Metabolism0.38
    3Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for HAS2
        Hyaluronan biosynthesis and export


    UniProtKB/Swiss-Prot: HYAS2_HUMAN, Q92819
    Pathway: Glycan biosynthesis; hyaluronan biosynthesis


    HAS2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HAS2
    Interactions:

        GeneGlobe Interaction Network for HAS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HAS2 (Q928193 ENSP000003069914) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAS3O002193, ENSP000003044404I2D: score=1 STRING: ENSP00000304440
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    KYENSP000003975984STRING: ENSP00000397598
    UPF2ENSP000003487084STRING: ENSP00000348708
    EXOC7ENSP000003341004STRING: ENSP00000334100
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis ISS--
    GO:0001822kidney development ISS--
    GO:0008284positive regulation of cell proliferation IMP--
    GO:0030212hyaluronan metabolic process ----
    GO:0030213hyaluronan biosynthetic process ISS--

    HAS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HAS2 (HYAS2)

    6 HMDB Compounds for HAS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronanhyaluronic acid (see all 13)9004-61-9--
    Hyaluronic acidhyaluronic acid 9004-61-9--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--

    Selected Novoseek inferred chemical compound relationships for HAS2 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycosaminoglycan 77.7 2 12757764 (1)
    hyaluronic acid 69.1 31 14752026 (5), 16339488 (3), 11470161 (2), 11991580 (1) (see all 12)
    4-methylumbelliferone 65.1 3 19285976 (2), 20332231 (1)
    udp glucuronic acid 55.7 2 19737932 (1), 19285976 (1)
    iloprost 41.2 4 14752026 (2), 19338584 (1)
    tgf beta1 40.4 3 16733556 (2)
    matrigel 32.5 4 17315194 (1), 19231585 (1)
    phosphoinositide 32.3 2 12954618 (1), 17324121 (1)
    pge2 12.2 1 14752026 (1)
    hydrocortisone 11.9 1 13130151 (1)



    HAS2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HAS2 gene: 
    NM_005328.2  

    Unigene Cluster for HAS2:

    Hyaluronan synthase 2
    Hs.159226  [show with all ESTs]
    Unigene Representative Sequence: NM_005328
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303924(uc003yph.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HAS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HAS2 (see all 51):
    hsa-miR-579 hsa-let-7d hsa-miR-376b hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-519a hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidHAS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HAS2
    Predesigned siRNA for gene silencing in human, mouse, rat HAS2
    Clone
    Products:
         
    OriGene clones in human, mouse for HAS2 (see all 7)
    OriGene ORF clones in mouse, rat for HAS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HAS2 (NM_005328)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HAS2
    OriGene qSTAR qPCR primer pairs in human, mouse for HAS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAS2
      QuantiTect SYBR Green Assays in human, mouse, rat HAS2
      QuantiFast Probe-based Assays in human, mouse, rat HAS2

    Additional mRNA sequence: 

    AK297724.1 BC069353.1 BC109071.1 BC109072.1 U54804.1 

    3 DOTS entries:

    DT.209587  DT.120637507  DT.204245 

    Selected AceView cDNA sequences (see all 35):

    AW068929 AI753259 BM975166 AI079360 AU280488 CA448459 BC069353 AI769070 
    AI754826 BX506849 AA579772 U54804 AI087079 BF941195 CD643217 AI374739 
    W49820 BE296170 NM_005328 BF436141 AA742706 AW069182 BE294176 BX956318 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HAS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAAAAGG
    HAS2 Expression
    About this image


    HAS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 13 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
     
     Cartilage (Muscoskeletal System)    fully expand to see all 12 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
     
     Heart (Cardiovascular System)    fully expand to see all 8 entries
             Endocardial Cells Endocardium
             Cardiomyocyte-like progenitor cells
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Prechondrocytic Mesenchymal Cells Stylopod
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Thalamus
    HAS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HAS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159226

    UniProtKB/Swiss-Prot: HYAS2_HUMAN, Q92819
    Tissue specificity: Expressed in fibroblasts

        Custom PCR Arrays for HAS2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HAS2
    OriGene qSTAR qPCR primer pairs in human, mouse for HAS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAS2
    QuantiTect SYBR Green Assays in human, mouse, rat HAS2
    QuantiFast Probe-based Assays in human, mouse, rat HAS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for HAS2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Has21 , 5 hyaluronan synthase 21, 5 90.94(n)1
    98.91(a)1
      15 (23.31 cM)5
    151171  NM_008216.31  NP_032242.31 
     566656275 
    chicken
    (Gallus gallus)
    Aves HAS21 hyaluronan synthase 2 84.78(n)
    93.3(a)
      395594  NM_204806.1  NP_990137.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    95(a)
    85(a)
    1 ↔ many
    1 ↔ many
    GL343269.1(1828808-1867583)
    AAWZ02037214(1173-1910)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6082 Xenopus laevis hyaluronan synthase 2 (HAS2) mRNA, complete more 79.65(n)    AF168465.1 
    zebrafish
    (Danio rerio)
    Actinopterygii has22 hyaluronan synthase 2 76.28(n)   260350  AF190742.1 


    ENSEMBL Gene Tree for HAS2 (if available)
    TreeFam Gene Tree for HAS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HAS2 gene
    HAS12  HAS32  
    2 SIMAP similar genes for HAS2 using alignment to 1 protein entry:     HYAS2_HUMAN:
    HAS3    HAS1

    HAS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HAS2 (see all 436)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70142901,2
    C,F,H--122624796(+) TATTCC/TGATTG 1 -- ds500113Minor allele frequency- T:0.03NS EA NA WA 1768
    rs352281941,2
    C--122625187(+) AGTTG-/AAAAAA 1 -- ds50010--------
    rs737080961,2
    C,F--122625215(+) AACATG/ATTCAA 1 -- ds50012Minor allele frequency- A:0.12WA 120
    rs168957761,2
    C,F--122625240(+) CCAGTA/GAATTC 1 -- ds50013Minor allele frequency- G:0.01NA 142
    rs1865814671,2
    --122625294(+) CAAAAC/TTATAC 1 -- ut310--------
    rs168957781,2
    C,F,H--122625388(+) GTTTTG/CTCCAG 1 -- ut318Minor allele frequency- C:0.02NA NS EA 682
    rs1395606141,2
    --122625488(+) TTCAAC/TGATTT 1 -- ut310--------
    rs1909872821,2
    --122625511(+) CACACA/GAAAGT 1 -- ut310--------
    rs1824104381,2
    --122625633(+) TTCAAA/TTTTAA 1 -- ut310--------
    rs78316851,2
    C,H--122625732(+) AATTTT/CTTAAG 1 -- ut316Minor allele frequency- C:0.03NS EA WA 522

    HapMap Linkage Disequilibrium report for HAS2 (122624356 - 122653630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HAS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831446CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HAS2
    DNA2.0 Custom Variant and Variant Library Synthesis for HAS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601636    OMIM disorders: --

    UniProtKB/Swiss-Prot: HYAS2_HUMAN, Q92819
  • Note=A chromosomal aberration involving HAS2 may be a cause of lipoblastomas, which are benign tumors
    resulting from transformation of adipocytes, usually diagnosed in children. 8q12.1 to 8q24.1 intrachromosomal
    rearrangement with PLAG1

  • Selected diseases for HAS2 (see all 37):    
    About MalaCards
    lipoblastoma    arthropathy    rheumatoid arthritis    noma
    osteosarcoma    morquio syndrome b    arthritis    sly syndrome
    eye disease    mucopolysaccharidoses    osteoarthritis    prostate adenocarcinoma
    fibrosarcoma    hyperglycemia    multiple myeloma    atopic dermatitis
    diabetic nephropathy    peritonitis    endometrial carcinoma    atherosclerosis


    HAS2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HAS2 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 47.6 2 19231585 (1)
    osteosarcoma 38.3 8 16540432 (3), 15922739 (2), 10861215 (1), 11171074 (1)
    tumors 28.2 14 16816377 (2), 17315194 (1), 19218337 (1), 16807238 (1) (see all 8)
    metastasis 22.5 4 19218337 (1)
    atherosclerosis 17.5 1 14752026 (1)
    prostate cancer 17.2 1 16816377 (1)
    necrosis 13.3 1 16818886 (1)
    cancer 10.6 5 19416972 (1), 16540432 (1), 14566823 (1)
    ovarian cancer 9.26 1 15375493 (1)
    osteoarthritis 8.11 1 15763928 (1)

    Genetic Association Database (GAD): HAS2
    Human Genome Epidemiology (HuGE) Navigator: HAS2 (2 documents)

    Export disorders for HAS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HAS2 gene, integrated from 10 sources (see all 176):
    (articles sorted by number of sources associating them with HAS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of a putative human hyaluronan synthase. (PubMed id 8798477)1, 2, 9 Watanabe K. and Yamaguchi Y. (J. Biol. Chem. 1996)
    2. Chromosomal localization of the human and mouse hyaluronan synthase genes. (PubMed id 9169154)1, 3, 9 Spicer A.P....McDonald J.A. (Genomics 1997)
    3. Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening. (PubMed id 18587729)1, 4, 9 Nair S....Bowen T. (J. Nephrol. 2008)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement. (PubMed id 15642402)1, 2 Morerio C.... Panarello C. (Cancer Genet. Cytogenet. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. (PubMed id 14752026)1, 9 Sussmann M....Fischer J.W. (Circ. Res. 2004)
    8. Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy. (PubMed id 16807238)1, 9 Cook A.C....Tuck A.B. (J. Biol. Chem. 2006)
    9. Natural antisense mRNAs to hyaluronan synthase 2 inhibit hyaluronan biosynthesis and cell proliferation. (PubMed id 15843373)1, 9 Chao H. and Spicer A.P. (J. Biol. Chem. 2005)
    10. Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells. (PubMed id 17315194)1, 9 Li Y....Heldin P. (Int. J. Cancer 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3037 HGNC: 4819 AceView: HAS2 Ensembl:ENSG00000170961 euGenes: HUgn3037
    ECgene: HAS2 H-InvDB: HAS2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HAS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HAS2 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=HAS2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HAS2 gene:
    Search GeneIP for patents involving HAS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HAS2
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HAS2  
     OriGene qPCR primer pairs and template standards for HAS2   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HAS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for HAS2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HAS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HAS2   OriGene Custom Protein Services for HAS2  

     
     
     Block miRNA regulation of human, mouse, rat HAS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HAS2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAS2 Predesigned siRNA for gene silencing in human, mouse, rat HAS2
     QuantiFast Probe-based Assays in human, mouse, rat HAS2 QuantiTect SYBR Green Assays in human, mouse, rat HAS2
     Custom PCR Arrays for HAS2 Search Chromatin IP Primers for HAS2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAS2  GeneGlobe Interaction Network for HAS2
     Regulatory tfbs in HAS2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HAS2 GenScript cDNA clones with any tag delivered in your preferred vector for HAS2
     GenScript Custom Assay Services for HAS2 GenScript Custom overexpressing Cell Line Services for HAS2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HAS2 (HYAS2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HAS2 proteins
     Antibodies for HAS2
     See all of Abcam's Antibodies, Kits and Proteins for HAS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HAS2
     Antibodies for HAS2
     ELISAs for HAS2
     CLIAs for HAS2



     Browse ESI BIO Cell Lines and PureStem Progenitors for HAS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS2
     SwitchGear 3'UTR luciferase reporter plasmids for HAS2
     SwitchGear Promoter luciferase reporter plasmids for HAS2
     ThermoFisher Antibody for HAS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAS2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HAS2
     LSBio Antibodies in human, mouse, rat for HAS2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HAS2 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4