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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HAS2 Gene

protein-coding   GIFtS: 60
GCID: GC08M122624

Hyaluronan Synthase 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hyaluronan Synthase 21 2
Hyaluronate Synthase 22 3
Hyaluronic Acid Synthase 22 3
HA Synthase 22 3
EC 2.4.1.2123 8

External Ids:    HGNC: 48191   Entrez Gene: 30372   Ensembl: ENSG000001709617   OMIM: 6016365   UniProtKB: Q928193   

Export aliases for HAS2 gene to outside databases

Previous GC identifers: GC08M121594 GC08M122683 GC08M122294 GC08M122582 GC08M122694 GC08M117950


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HAS2 Gene:
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide
variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of
alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic
bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains
are extruded through pore-like structures into the extracellular space. It serves a variety of functions,
including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is
actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and
fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative
arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44
is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with
tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan
synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from
Xenopus laevis, and human and murine hyaluronan synthase 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for HAS2 Gene: 
HAS2 (hyaluronan synthase 2) is a protein-coding gene. Diseases associated with HAS2 include lipoblastoma, and arthropathy, and among its related super-pathways are Metabolism of carbohydrates and Hyaluronan uptake and degradation. GO annotations related to this gene include hyaluronan synthase activity. An important paralog of this gene is HAS1.

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819
Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis

Gene Wiki entry for HAS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HAS2 gene promoter:
         Egr-3   RFX1   AP-4   XBP-1   Cdc5   HEN1   Ik-2   E2F-1   Cart-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HAS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.12   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.12

HAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAS2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M122624:  view genomic region     (about GC identifiers)

Start:
122,624,356 bp from pter      End:
122,653,630 bp from pter
Size:
29,275 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819 (See protein sequence)
Recommended Name: Hyaluronan synthase 2  
Size: 552 amino acids; 63566 Da
Cofactor: Magnesium
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Secondary accessions: Q32MM3

Explore the universe of human proteins at neXtProt for HAS2: NX_Q92819

Explore proteomics data for HAS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92819

  • 4/27 DME Specific Peptides for HAS2 (Q92819) (see all 27)
     QVCDSDT  DYLRKCL  TKYTARS  LEHRKMK 

    HAS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HAS2 Protein Expression
    REFSEQ proteins: NP_005319.1  
    ENSEMBL proteins: 
     ENSP00000306991  
    Reactome Protein details: Q92819
    Human Recombinant Protein Products for HAS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HAS2
    GenScript Custom Purified and Recombinant Proteins Services for HAS2
    Novus Biologicals HAS2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HAS2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IDA--

    HAS2 for ontologies           About GeneDecksing



    HAS2 Antibody Products: 
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    ThermoFisher Antibody for HAS2
    LSBio Antibodies in human, mouse, rat for HAS2 

    Assay Products for HAS2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HAS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HAS2 
    Cloud-Clone Corp. CLIAs for HAS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GLT2: Glycosyltransferase family 2 domain containing

    2 InterPro protein domains:
     IPR026107 HAS/NodC
     IPR004835 Chitin_synth_fng

    Graphical View of Domain Structure for InterPro Entry Q92819

    ProtoNet protein and cluster: Q92819

    1 Blocks protein domain: IPB001173 Glycosyl transferase

    UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819
    Similarity: Belongs to the NodC/HAS family


    HAS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HAS2_HUMAN, Q92819
    Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis
    Catalytic activity: UDP-alpha-N-acetyl-D-glucosamine +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP +
    N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent
    hyaluronan)
    Catalytic activity: UDP-alpha-D-glucuronate +
    N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)

         Genatlas biochemistry entry for HAS2:
    hyaluronan synthase gene 2

         Enzyme Number (IUBMB): EC 2.4.1.2121 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0050501hyaluronan synthase activity ISS--
         
    HAS2 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Has2):
     behavior/neurological  cardiovascular system  craniofacial  embryogenesis  growth/size 
     homeostasis/metabolism  limbs/digits/tail  mortality/aging  muscle  no phenotypic analysis 
     normal  skeleton 

    HAS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HAS2: Has2tm1Jam Has2tm1.2Nita

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HAS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HAS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAS2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target HAS2:
    hsa-mir-204 (MIRT005828)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAS2
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate HAS2 (see all 51):
    hsa-miR-579 hsa-let-7d hsa-miR-376b hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-519a hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidHAS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HAS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAS2

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of HAS2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HAS2 (see all 7)
    OriGene ORF clones in mouse, rat for HAS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HAS2 (NM_005328)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS2
    Sirion Biotech Customized lentivirus for stable overexpression of HAS2 
                         Customized lentivirus expression plasmids for stable overexpression of HAS2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HAS2
    Search LifeMap BioReagents cell lines for HAS2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HAS2 About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    2Hyaluronan uptake and degradation
    Hyaluronan metabolism0.71
    3Metabolism
    Metabolism0.40
    4Hyaluronan biosynthesis and export
    Hyaluronan biosynthesis and export
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/18        Reactome Pathways for HAS2 (see all 18)
        Hyaluronan metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS II - Hunter syndrome


    UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819
    Pathway: Glycan biosynthesis; hyaluronan biosynthesis


    HAS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HAS2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for HAS2 (Q928193 ENSP000003069914) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAS3O002193, ENSP000003044404I2D: score=1 STRING: ENSP00000304440
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis ISS--
    GO:0001822kidney development ISS--
    GO:0008284positive regulation of cell proliferation IMP--
    GO:0030212hyaluronan metabolic process ----
    GO:0030213hyaluronan biosynthetic process ISS--

    HAS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HAS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HAS2

    6 HMDB Compounds for HAS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronanhyaluronic acid (see all 13)9004-61-9--
    Hyaluronic acidhyaluronic acid 9004-61-9--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--

    10/19 Novoseek inferred chemical compound relationships for HAS2 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycosaminoglycan 77.7 2 12757764 (1)
    hyaluronic acid 69.1 31 14752026 (5), 16339488 (3), 11470161 (2), 11991580 (1) (see all 12)
    4-methylumbelliferone 65.1 3 19285976 (2), 20332231 (1)
    udp glucuronic acid 55.7 2 19737932 (1), 19285976 (1)
    iloprost 41.2 4 14752026 (2), 19338584 (1)
    tgf beta1 40.4 3 16733556 (2)
    matrigel 32.5 4 17315194 (1), 19231585 (1)
    phosphoinositide 32.3 2 12954618 (1), 17324121 (1)
    pge2 12.2 1 14752026 (1)
    hydrocortisone 11.9 1 13130151 (1)

    Search CenterWatch for drugs/clinical trials and news about HAS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HAS2 gene: 
    NM_005328.2  

    Unigene Cluster for HAS2:

    Hyaluronan synthase 2
    Hs.159226  [show with all ESTs]
    Unigene Representative Sequence: NM_005328
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303924(uc003yph.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAS2
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate HAS2 (see all 51):
    hsa-miR-579 hsa-let-7d hsa-miR-376b hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-519a hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidHAS2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for HAS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAS2
    Clone
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    OriGene clones in human, mouse for HAS2 (see all 7)
    OriGene ORF clones in mouse, rat for HAS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HAS2 (NM_005328)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS2
    Sirion Biotech Customized lentivirus for stable overexpression of HAS2 
                         Customized lentivirus expression plasmids for stable overexpression of HAS2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAS2

    Additional mRNA sequence: 

    AK297724.1 BC069353.1 BC109071.1 BC109072.1 U54804.1 

    3 DOTS entries:

    DT.209587  DT.120637507  DT.204245 

    24/35 AceView cDNA sequences (see all 35):

    BM975166 AW068929 AI079360 AI753259 CA448459 AU280488 BC069353 BF941195 
    U54804 AA579772 AI754826 CD643217 AI087079 AW069182 AI769070 AA742706 
    BX506849 BE296170 NM_005328 BF436141 AI374739 W49820 BX956318 AI571514 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HAS2 expression in normal human tissues (normalized intensities)      HAS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAAAAGG
    HAS2 Expression
    About this image


    HAS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 13 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
     
     Cartilage (Muscoskeletal System)    fully expand to see all 12 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
     
     Heart (Cardiovascular System)    fully expand to see all 8 entries
             Endocardial Cells Endocardium
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
             heart/atrium   
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Prechondrocytic Mesenchymal Cells Stylopod
             Human fetal bone marrow-derived mesenchymal stromal cells
             BONE MARROW   
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Thalamus
             brain/forebrain/telencephalon   

    See HAS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HAS2

    SOURCE GeneReport for Unigene cluster: Hs.159226

    UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819
    Tissue specificity: Expressed in fibroblasts

        SABiosciences Custom PCR Arrays for HAS2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HAS2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HAS2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAS2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HAS2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Has21 , 5 hyaluronan synthase 21, 5 90.94(n)1
    98.91(a)1
      15 (23.31 cM)5
    151171  NM_008216.31  NP_032242.31 
     566656275 
    chicken
    (Gallus gallus)
    Aves HAS21 hyaluronan synthase 2 84.78(n)
    93.3(a)
      395594  NM_204806.1  NP_990137.1 
    lizard
    (Anolis carolinensis)
    Reptilia HAS26
    --
    (see all 3)
    --
    95(a)
    86(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    GL343269.1(1828808-1867583)
    AAWZ02037214(1173-1910)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6082 Xenopus laevis hyaluronan synthase 2 (HAS2) mRNA, complete more 79.65(n)    AF168465.1 
    zebrafish
    (Danio rerio)
    Actinopterygii has22 hyaluronan synthase 2 76.28(n)   260350  AF190742.1 


    ENSEMBL Gene Tree for HAS2 (if available)
    TreeFam Gene Tree for HAS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HAS2 gene
    HAS12  HAS32  
    2 SIMAP similar genes for HAS2 using alignment to 1 protein entry:     HAS2_HUMAN:
    HAS3    HAS1

    HAS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/436 SNPs in HAS2 are shown (see all 436)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70142901,2
    C,F,H--122624796(+) TATTCC/TGATTG 1 -- ds500113Minor allele frequency- T:0.03NS EA NA WA 1768
    rs352281941,2
    C--122625187(+) AGTTG-/AAAAAA 1 -- ds50010--------
    rs737080961,2
    C,F--122625215(+) AACATG/ATTCAA 1 -- ds50012Minor allele frequency- A:0.12WA 120
    rs168957761,2
    C,F--122625240(+) CCAGTA/GAATTC 1 -- ds50013Minor allele frequency- G:0.01NA 142
    rs1865814671,2
    --122625294(+) CAAAAC/TTATAC 1 -- ut310--------
    rs168957781,2
    C,F,H--122625388(+) GTTTTG/CTCCAG 1 -- ut318Minor allele frequency- C:0.02NA NS EA 682
    rs1395606141,2
    --122625488(+) TTCAAC/TGATTT 1 -- ut310--------
    rs1909872821,2
    --122625511(+) CACACA/GAAAGT 1 -- ut310--------
    rs1824104381,2
    --122625633(+) TTCAAA/TTTTAA 1 -- ut310--------
    rs78316851,2
    C,H--122625732(+) AATTTT/CTTAAG 1 -- ut316Minor allele frequency- C:0.03NS EA WA 522

    HapMap Linkage Disequilibrium report for HAS2 (122624356 - 122653630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HAS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831446CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for HAS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601636    OMIM disorders: --

    UniProtKB/Swiss-Prot: HAS2_HUMAN, Q92819
  • Note=A chromosomal aberration involving HAS2 may be a cause of lipoblastomas, which are benign tumors
    resulting from transformation of adipocytes, usually diagnosed in children. 8q12.1 to 8q24.1 intrachromosomal
    rearrangement with PLAG1

  • 20/30 diseases for HAS2 (see all 30):    About MalaCards
    lipoblastoma    arthropathy    rheumatoid arthritis    noma
    osteosarcoma    morquio syndrome b    arthritis    eye disease
    osteoarthritis    benign tumors    prostate adenocarcinoma    atopic dermatitis
    peritonitis    fibrosarcoma    hyperglycemia    multiple myeloma
    endometrial carcinoma    dermatitis    periodontitis    myeloma


    HAS2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/15 Novoseek inferred disease relationships for HAS2 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 47.6 2 19231585 (1)
    osteosarcoma 38.3 8 16540432 (3), 15922739 (2), 10861215 (1), 11171074 (1)
    tumors 28.2 14 16816377 (2), 17315194 (1), 19218337 (1), 16807238 (1) (see all 8)
    metastasis 22.5 4 19218337 (1)
    atherosclerosis 17.5 1 14752026 (1)
    prostate cancer 17.2 1 16816377 (1)
    necrosis 13.3 1 16818886 (1)
    cancer 10.6 5 19416972 (1), 16540432 (1), 14566823 (1)
    ovarian cancer 9.26 1 15375493 (1)
    osteoarthritis 8.11 1 15763928 (1)

    Genetic Association Database (GAD): HAS2
    Human Genome Epidemiology (HuGE) Navigator: HAS2 (2 documents)

    Export disorders for HAS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HAS2 gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with HAS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of a putative human hyaluronan synthase. (PubMed id 8798477)1, 2, 9 Watanabe K. and Yamaguchi Y. (1996)
    2. Chromosomal localization of the human and mouse hyaluronan synthase genes. (PubMed id 9169154)1, 3, 9 Spicer A.P....McDonald J.A. (1997)
    3. Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening. (PubMed id 18587729)1, 4, 9 Nair S....Bowen T. (2008)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement. (PubMed id 15642402)1, 2 Morerio C.... Panarello C. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. (PubMed id 14752026)1, 9 Sussmann M....Fischer J.W. (2004)
    8. Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy. (PubMed id 16807238)1, 9 Cook A.C....Tuck A.B. (2006)
    9. Natural antisense mRNAs to hyaluronan synthase 2 inhibit hyaluronan biosynthesis and cell proliferation. (PubMed id 15843373)1, 9 Chao H. and Spicer A.P. (2005)
    10. Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells. (PubMed id 17315194)1, 9 Li Y....Heldin P. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3037 HGNC: 4819 AceView: HAS2 Ensembl:ENSG00000170961 euGenes: HUgn3037
    ECgene: HAS2 H-InvDB: HAS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HAS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HAS2 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HAS2 gene:
    Search GeneIP for patents involving HAS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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     Regulatory tfbs in HAS2 promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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