V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

HAS1 Gene

protein-coding GIFtS: 59

GC19M056908

hyaluronan synthase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HAS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.4.1.212 ^³
HAS ^², ³
HuHAS1 ^³

Descriptions
HA synthase 1 ^², ³
Hyaluronate synthase 1 ^², ³
Hyaluronic acid synthase 1 ^², ³
hyaluronan synthase 1 ^²

External Ids
HGNC: 4818¹
Entrez Gene: 3036²
UniProtKB: Q92839³
Ensembl: ENSG00000105509⁷

Search outside databases for aliases for HAS1 gene

Previous GC identifers: GC19M052846 GC19M052577 GC19M056892

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HAS1:

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized

by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular

matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are

linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at

the inner surface of the plasma membrane, and the chains are extruded through pore-like structures

into the extracellular space. It serves a variety of functions, including space filling,

lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively

produced during wound healing and tissue repair to provide a framework for ingrowth of blood

vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory

and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA

with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and

overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the

newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid

sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a

glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine

hyaluronan synthase. [provided by RefSeq]

UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839

Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the

synthesis of chito-oligosaccharide depending on the substrate

Gene Wiki entry for HAS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HAS1 gene

Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3-q13.4

HAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M056908: (about GC identifiers)

Start:	56,908,177 bp from pter
End:	56,919,049 bp from pter
Size:	10,873 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839 (See protein sequence)

Recommended Name: Hyaluronan synthase 1

Size: 578 amino acids; 64832 Da

Cofactor: Magnesium

Subcellular location: Membrane; Multi-pass membrane protein (Probable)

Secondary accessions: Q14470 Q9NS49

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001514.2

ENSEMBL proteins:

ENSP00000222115 ENSP00000365928 ENSP00000365927

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Hyaluronan synthase 1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	9169154
GO:0016020	membrane	IEA	--

About this table

Antibodies for HAS1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Hyaluronan synthase 1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for HAS1

Assays for HAS1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q92839

ProtoNet protein and cluster: Q92839

1 Blocks protein family: IPB001173 Glycosyl transferase

UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839

Similarity: Belongs to the nodC/HAS family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAS1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC035837

Applied Biosystems Silencer® siRNAs for HAS1

Sigma-Aldrich siRNA and siRNA Panels for HAS1

Sigma-Aldrich shRNA Panels and shRNA for HAS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001523
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001523
untagged cDNA clones in CMV expression vector (see all 2): BC035837

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001523

UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839

Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the

synthesis of chito-oligosaccharide depending on the substrate

Catalytic activity: UDP-alpha-N-acetyl-D-glucosamine +

beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP +

N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent

hyaluronan)

Catalytic activity: UDP-alpha-D-glucuronate +

N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP +

beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent

hyaluronan)

Enzyme Number (IUBMB): EC 2.4.1.212

Genatlas biochemistry entry for HAS1:

hyaluronan synthase gene 1

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17353931
GO:0016757	transferase activity, transferring glycosyl groups	IEA	--
GO:0050501	hyaluronan synthase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for HAS1 (Your Favorite Gene powered by Ingenuity)

Inositol Metabolism

GeneDecks HAS1 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839

Pathway: Glycan biosynthesis; hyaluronan biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for HAS1

5/8 Interacting proteins for HAS1 (ENSP00000222115³ Q92839¹) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF6	P56537¹	EBI-1052423, EBI-372243
VHL	P40337¹	EBI-1052423, EBI-301246
SLC4A1	ENSP00000262418³	STRING (score=.842)
CD44	ENSP00000278385³	STRING (score=.827)
KRT32	ENSP00000225899³	STRING (score=.748)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006024	glycosaminoglycan biosynthetic process	TAS	8798544
GO:0007155	cell adhesion	TAS	8798544

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HAS1
1 Novoseek chemical compound relationship for HAS1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glycosaminoglycan	73.21	1	8798544 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAS1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC035837

Sigma-Aldrich siRNA and siRNA Panels for HAS1

Sigma-Aldrich shRNA Panels and shRNA for HAS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001523

REFSEQ mRNAs for HAS1 gene:

NM_001523.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001523

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001523
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001523
                                 untagged cDNA clones in CMV expression vector (see all 2): BC035837

Additional cDNA sequence:

AY916555.1 AY916556.1 BC035837.1 CR602106.1 D84424.1 U59269.1

3 DOTS entries:

DT.303900 DT.100711622 DT.97833965

21 AceView cDNA sequences:

CR602106 BQ772231 BG707608 AL545447 U59269 BI753116 NM_001523 BC035837

BG707429 BM543754 BM544718 AL571167 D84424 AW873943 BQ447523 BX281117

BX327795 BQ002782 CB266804 BF000543 BM083486

highest scoring ESTs for HAS1:

BC035837 D84424 U59269 AL545447 AW873943 BF000543 BG707429 BG707608 BI753116 BM083486

Unigene Cluster for HAS1:

Hyaluronan synthase 1

Hs.57697 [show with all ESTs]

Unigene Representative Sequence: BC035837

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for HAS1

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:			-										-		-
SP2:			-										-		-
SP3:													-		-
SP4:															-
SP5:											-		-

About this scheme

ECgene alternative splicing isoforms for HAS1

3 Ensembl transcripts including schematic representations:

ENST00000222115 ENST00000376738 ENST00000376737

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HAS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HAS1

¹ / ² / ³

3 probe-sets matching HAS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32424_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D84424	0.80	1.00	0.91	1
207316_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001523	0.60	1.00	0.82	1
207316_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HAS1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGACGCTGT

SOURCE GeneReport for Unigene cluster: Hs.57697
Expression variation in blood from EXPOLDB for HAS1
UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839
Tissue specificity: Highly expressed in ovary followed by spleen, thymus, prostate, testes and
large intestine. Weakly expressed in small intestine

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HAS1 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HAS1¹	--	hyaluronan synthase 1	87.6(n) 91.4(a)	611700 XM_849398.1 XP_854491.1
rat (Rattus norvegicus)	Has1¹	--	hyaluronan synthase 1	84.95(n) 96.01(a)	282821 NM_172323.1 NP_758826.1
mouse (Mus musculus)	Has1^{1, 5}	17 (10.00 cM)⁵	hyaluronan synthase1^{1, 5}	84.66(n)¹ 96.35(a)¹	15116¹ NM_008215.1¹ NP_032241.1¹ AK053726⁵ AK138203⁵ (see all 9)
zebrafish (Danio rerio)	has1¹	--	hyaluronan synthase 1	61.76(n) 60.64(a)	403130 XM_691522.2 XP_696614.2

About this table Species with no ortholog for HAS1

ENSEMBL Gene Tree for HAS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HAS1 gene

HAS3² HAS2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/127 NCBI SNPs in HAS1 are shown (see all 127 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 52)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs3829649^1,2	A,C,F,H	56908276(-)	`GGGATT/CTGAGG`	1	--	ut3¹ ese³		8		EU EA WA	824
	rs3764545^1,2	A,C,F,H	56919743(-)	`GTGTGA/TGTTTC`	1	--	ng3¹		8		EU EA WA	830
	rs10417548^1,2	C,F,H	56919825(+)	`TGAACG/ATCTGT`	1	--	ng3¹		7		EU EA WA NA	560
	rs3829654^1,2	C,F,H	56908107(-)	`CAGTGC/GTGGGT`	1	--	ng5¹		8		EU EA WA	824
	rs3794977^1,2	C,F,H	56920571(-)	`GTCAGG/AGAGAG`	1	--	ng3¹		5		EA EU WA	1892
	rs11672222^1,2	C,F,H	56919728(+)	`ACTGGT/CAGATG`	1	--	ng3¹		11		EU EA WA NA	972
	rs3829646^1,2	C,F,H	56920213(-)	`GCTACC/TGAGGC`	1	--	ng3¹		8		EU EA WA	810
	rs3794978^1,2	C,F,H	56920301(-)	`CTCCAT/CGTCTT`	1	--	ng3¹		4		EA EU	1802
	rs3794981^1,2	F,H	56919924(-)	`CATCCC/TTGAGT`	1	--	ng3¹		3		EU EA	294
	rs3829653^1,2	A,C	56908143(-)	`GGGGAA/CTGGAT`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for HAS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601463

9 Novoseek disease relationships for HAS1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
waldenstrom macroglobulinemia	61.08	6	18815290 (2), 15794859 (1)
rheumatoid arthritis	25.82	2	15763928 (1), 15535829 (1)
osteoarthritis	23.33	2	15763928 (1), 15535829 (1)
ovarian cancer	15.22	2	15375493 (2)
tumors	10.63	8	14676202 (1), 15763928 (1), 17230515 (1), 17315194 (1) (see all 7)
necrosis	0.00	2	14676202 (1), 15763928 (1)
cancer	0.00	2	14566823 (1), 15231668 (1)
inflammation	0.00	2	18393848 (1), 16904269 (1)
breast cancer	0.00	3	17315194 (1), 16642399 (1)

About this table

Genetic Association Database: HAS1
Human Genome Epidemiology Navigator: HAS1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/79 PubMed articles for HAS1 gene (see all 79 ):

Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia. (PubMed id 15794859)^{1, 3, 6} Adamia S....Pilarski L.M. (2005)
Chromosomal localization of the human and mouse hyaluronan synthase genes. (PubMed id 9169154)^{1, 2, 3} Spicer A.P....McDonald J.A. (1997)
Functional cloning of the cDNA for a human hyaluronan synthase. (PubMed id 8798544)^{1, 3, 4} Shyjan A.M.... Briskin M.J. (1996)
Molecular cloning of human hyaluronan synthase. (PubMed id 8651928)^{3, 4} Itano N. and Kimata K. (1996)
Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma. (PubMed id 15731173)^{1, 3} Adamia S....Pilarski L.M. (2005)
Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia. (PubMed id 18815290)^{1, 3} Adamia S....Pilarski L.M. (2008)
Adenovirus-mediated gene transfer of mutated IkappaB kinase and IkappaBalpha reveal NF-kappaB-dependent as well as NF-kappaB-independent pathways of HAS1 activation. (PubMed id 16258173)^{1, 3} Stuhlmeier K.M. and Pollaschek C. (2005)
The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1. (PubMed id 16723203)^{1, 3} Kao J.J. (2006)
Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44. (PubMed id 18199543)^{1, 3} Golshani R....Lokeshwar V.B. (2008)
Involvement of hyaluronan in regulation of fibroblast phenotype. (PubMed id 17611197)^{1, 3} Meran S....Steadman R. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3036	HGNC: 4818	AceView: HAS1	Ensembl:ENSG00000105509	euGenes: HUgn3036
ECgene: HAS1	H-InvDB: HAS1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for HAS1	Genetics and Cytogenetics in Oncology and Haematology
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/

Licensable Technologies for HAS1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HAS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HAS1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HAS1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HAS1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Hyaluronan synthase 1)
	Antibodies (Hyaluronan synthase 1)

Search OriGene for HAS1

Search Tocris compounds for HAS1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for HAS1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
HAS1 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

HAS1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for HAS1

Summaries
for HAS1

Genomic Location
for HAS1

Proteins
for HAS1

Protein Domains/
Families
for HAS1

Gene Function
for HAS1

Pathways & Interactions
for HAS1

Drugs & Compounds
for HAS1

Transcripts
for HAS1

Expression
for HAS1

Orthologs
for HAS1

Paralogs
for HAS1

SNPs/Variants
for HAS1

Disorders & Mutations
for HAS1

Medical News
for HAS1

Publications
for HAS1

Search for HAS1

Genome Databases showing HAS1

Other Databases showing HAS1

Specialized Databases showing HAS1

Licensable Technologies
for HAS1

Services
for HAS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HAS1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor HAS1

Summariesfor HAS1

Genomic Locationfor HAS1

Proteinsfor HAS1

Protein Domains/Familiesfor HAS1

Gene Functionfor HAS1

Pathways & Interactionsfor HAS1

Drugs & Compoundsfor HAS1

Transcriptsfor HAS1

Expression for HAS1

Orthologsfor HAS1

Paralogsfor HAS1

SNPs/Variantsfor HAS1

Disorders & Mutationsfor HAS1

Medical Newsfor HAS1

Publicationsfor HAS1

Search for HAS1

Genome Databases showing HAS1

Other Databases showing HAS1

Specialized Databases showing HAS1

Licensable Technologiesfor HAS1

Servicesfor HAS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HAS1

Summaries
for HAS1

Genomic Location
for HAS1

Proteins
for HAS1

Protein Domains/
Families
for HAS1

Gene Function
for HAS1

Pathways & Interactions
for HAS1

Drugs & Compounds
for HAS1

Transcripts
for HAS1

Expression
for HAS1

Orthologs
for HAS1

Paralogs
for HAS1

SNPs/Variants
for HAS1

Disorders & Mutations
for HAS1

Medical News
for HAS1

Publications
for HAS1

Licensable Technologies
for HAS1

Services
for HAS1