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Aliases for HAS1 Gene

Aliases for HAS1 Gene

  • Hyaluronan Synthase 1 2 3
  • Hyaluronic Acid Synthase 1 3 4
  • Hyaluronate Synthase 1 3 4
  • HA Synthase 1 3 4
  • HAS 3 4
  • EC 2.4.1.212 4
  • HuHAS1 4

External Ids for HAS1 Gene

Previous HGNC Symbols for HAS1 Gene

  • HAS

Previous GeneCards Identifiers for HAS1 Gene

  • GC19M052846
  • GC19M052577
  • GC19M056892
  • GC19M056908
  • GC19M052216
  • GC19M048547

Summaries for HAS1 Gene

Entrez Gene Summary for HAS1 Gene

  • Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for HAS1 Gene

HAS1 (Hyaluronan Synthase 1) is a Protein Coding gene. Diseases associated with HAS1 include peritoneal mesothelioma and malignant peritoneal mesothelioma. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include hyaluronan synthase activity. An important paralog of this gene is HAS3.

UniProtKB/Swiss-Prot for HAS1 Gene

  • Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).

Gene Wiki entry for HAS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAS1 Gene

Genomics for HAS1 Gene

Regulatory Elements for HAS1 Gene

Genomic Location for HAS1 Gene

Start:
51,713,112 bp from pter
End:
51,723,994 bp from pter
Size:
10,883 bases
Orientation:
Minus strand

Genomic View for HAS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAS1 Gene

Proteins for HAS1 Gene

  • Protein details for HAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92839-HYAS1_HUMAN
    Recommended name:
    Hyaluronan synthase 1
    Protein Accession:
    Q92839
    Secondary Accessions:
    • Q14470
    • Q9NS49

    Protein attributes for HAS1 Gene

    Size:
    578 amino acids
    Molecular mass:
    64832 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA12351.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for HAS1 Gene

Proteomics data for HAS1 Gene at MOPED

Post-translational modifications for HAS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HAS1 Gene

No data available for DME Specific Peptides for HAS1 Gene

Domains for HAS1 Gene

Gene Families for HAS1 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Protein Domains for HAS1 Gene

Suggested Antigen Peptide Sequences for HAS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92839

UniProtKB/Swiss-Prot:

HYAS1_HUMAN :
  • Q92839
Family:
  • Belongs to the NodC/HAS family.
genes like me logo Genes that share domains with HAS1: view

Function for HAS1 Gene

Molecular function for HAS1 Gene

GENATLAS Biochemistry: hyaluronan synthase gene 1
UniProtKB/Swiss-Prot CatalyticActivity: UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan)
UniProtKB/Swiss-Prot CatalyticActivity: UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)
UniProtKB/Swiss-Prot Function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).

Enzyme Numbers (IUBMB) for HAS1 Gene

Gene Ontology (GO) - Molecular Function for HAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050501 hyaluronan synthase activity ISS --
genes like me logo Genes that share ontologies with HAS1: view
genes like me logo Genes that share phenotypes with HAS1: view

Animal Models for HAS1 Gene

MGI Knock Outs for HAS1:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for HAS1 Gene

Localization for HAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAS1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAS1 Gene COMPARTMENTS Subcellular localization image for HAS1 gene
Compartment Confidence
plasma membrane 4
golgi apparatus 3
extracellular 2
endoplasmic reticulum 1
endosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9169154
GO:0016020 membrane --
genes like me logo Genes that share ontologies with HAS1: view

Pathways for HAS1 Gene

genes like me logo Genes that share pathways with HAS1: view

Pathways by source for HAS1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
    • Extracellular Matrix & Adhesion Molecules in human,mouse,rat

UniProtKB/Swiss-Prot Q92839-HYAS1_HUMAN

  • Pathway: Glycan biosynthesis; hyaluronan biosynthesis

Gene Ontology (GO) - Biological Process for HAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS 8798544
GO:0007155 cell adhesion TAS 8798544
GO:0010764 negative regulation of fibroblast migration IMP 19577615
GO:0030203 glycosaminoglycan metabolic process TAS --
genes like me logo Genes that share ontologies with HAS1: view

Compounds for HAS1 Gene

(6) HMDB Compounds for HAS1 Gene

Compound Synonyms Cas Number PubMed IDs
Hyaluronan
  • hyaluronic acid
9004-61-9
Hyaluronic acid
  • hyaluronic acid
9004-61-9
Magnesium
  • Magnesium
7439-95-4
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate glucuronic acid
  • UDP glucuronate
2616-64-0

(3) Novoseek inferred chemical compound relationships for HAS1 Gene

Compound -log(P) Hits PubMed IDs
glycosaminoglycan 75.5 1
hyaluronic acid 64.3 17
hydrocortisone 22.1 3
genes like me logo Genes that share compounds with HAS1: view

Transcripts for HAS1 Gene

Unigene Clusters for HAS1 Gene

Hyaluronan synthase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAS1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAS1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for HAS1 Gene

GeneLoc Exon Structure for
HAS1
ECgene alternative splicing isoforms for
HAS1

Expression for HAS1 Gene

mRNA expression in normal human tissues for HAS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAS1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (13.7), Ovary (5.8), and Heart - Atrial Appendage (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HAS1 Gene

SOURCE GeneReport for Unigene cluster for HAS1 Gene Hs.57697

mRNA Expression by UniProt/SwissProt for HAS1 Gene

Q92839-HYAS1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine.
genes like me logo Genes that share expressions with HAS1: view

In Situ Assay Products

Orthologs for HAS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAS1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HAS1 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAS1 35
  • 87.27 (n)
  • 90.62 (a)
HAS1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Has1 35
  • 84.43 (n)
  • 95.31 (a)
Has1 16
Has1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HAS1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAS1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Has1 35
  • 84.61 (n)
  • 94.79 (a)
lizard
(Anolis carolinensis)
Reptilia HAS1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491673 35
  • 61.78 (n)
  • 62.57 (a)
zebrafish
(Danio rerio)
Actinopterygii has1 35
  • 61.94 (n)
  • 60.82 (a)
has1 36
  • 55 (a)
OneToOne
Species with no ortholog for HAS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAS1 Gene

ENSEMBL:
Gene Tree for HAS1 (if available)
TreeFam:
Gene Tree for HAS1 (if available)

Paralogs for HAS1 Gene

Paralogs for HAS1 Gene

Selected SIMAP similar genes for HAS1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with HAS1: view

Variants for HAS1 Gene

Sequence variations from dbSNP and Humsavar for HAS1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1551155 -- 51,721,122(+) aaggt(C/T)gtccc intron-variant
rs3764543 -- 51,725,866(-) CTTGA(A/G)GTCAG upstream-variant-2KB
rs3764544 -- 51,725,794(-) TAGCC(A/G)GGTGT upstream-variant-2KB
rs3764545 -- 51,724,678(-) GTGTG(A/T)GTTTC upstream-variant-2KB
rs3764546 -- 51,724,672(-) GTTTC(A/G)TTCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HAS1 Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
dgv1110e1 CNV Complex 17122850
nsv912296 CNV Loss 21882294
nsv9742 CNV Gain+Loss 18304495
nsv912297 CNV Loss 21882294
nsv524403 CNV Gain 19592680
nsv470151 CNV Gain 18288195
nsv458733 CNV Gain 19166990

Relevant External Links for HAS1 Gene

HapMap Linkage Disequilibrium report
HAS1
Human Gene Mutation Database (HGMD)
HAS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAS1 Gene

Disorders for HAS1 Gene

(1) University of Copenhagen DISEASES for HAS1 Gene

(10) Novoseek inferred disease relationships for HAS1 Gene

Disease -log(P) Hits PubMed IDs
waldenstrom macroglobulinemia 63.5 3
rheumatoid arthritis 21.8 2
ovarian cancer 20.1 2
osteoarthritis 19.1 2
tumors 7.86 7

Relevant External Links for HAS1

Genetic Association Database (GAD)
HAS1
Human Genome Epidemiology (HuGE) Navigator
HAS1
genes like me logo Genes that share disorders with HAS1: view

No data available for UniProtKB/Swiss-Prot for HAS1 Gene

Publications for HAS1 Gene

  1. Chromosomal localization of the human and mouse hyaluronan synthase genes. (PMID: 9169154) Spicer A.P. … McDonald J.A. (Genomics 1997) 2 3 23
  2. Functional cloning of the cDNA for a human hyaluronan synthase. (PMID: 8798544) Shyjan A.M. … Briskin M.J. (J. Biol. Chem. 1996) 3 4 23
  3. Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia. (PMID: 15794859) Adamia S. … Pilarski L.M. (Clin Lymphoma 2005) 3 23 48
  4. Adenovirus-mediated gene transfer of mutated IkappaB kinase and IkappaBalpha reveal NF-kappaB-dependent as well as NF-kappaB-independent pathways of HAS1 activation. (PMID: 16258173) Stuhlmeier K.M. … Pollaschek C. (J. Biol. Chem. 2005) 3 23
  5. Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta. (PMID: 14636845) Suzuki K. … Yamashita H. (Jpn. J. Ophthalmol. 2003) 3 23

Products for HAS1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
    • Extracellular Matrix & Adhesion Molecules in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HAS1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HAS1
    • Block miRNA regulation of HAS1 using miScript Target Protectors

    Sources for HAS1 Gene

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