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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HAS1 Gene

protein-coding GIFtS: 63
GCID: GC19M052216

hyaluronan synthase 1

(Previous symbol: HAS)

Explore 38 diseases affiliated with
HAS1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hyaluronan Synthase 1¹ ²		HA Synthase 1² ³
HAS¹ ² ³		EC 2.4.1.212³ ⁸
Hyaluronate Synthase 1² ³		HuHAS1³
Hyaluronic Acid Synthase 1² ³		HuHAS1³

External Ids:	HGNC: 4818¹	Entrez Gene: 3036²	Ensembl: ENSG00000105509⁷	OMIM: 601463⁵	UniProtKB: Q92839³

Export aliases for HAS1 gene to outside databases

Previous GC identifers: GC19M052846 GC19M052577 GC19M056892 GC19M056908 GC19M048547

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HAS1:

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety

of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating

glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is

synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded

through pore-like structures into the extracellular space. It serves a variety of functions, including space filling,

lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound

healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum

concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In

addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes,

and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified

vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology

to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a

recently described murine hyaluronan synthase. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839

Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of

chito-oligosaccharide depending on the substrate

Gene Wiki entry for HAS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HAS1 gene promoter:
p53 AP-1 ATF-2 Olf-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HAS1 promoter sequence

Search SABiosciences Chromatin IP Primers for HAS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.3-q13.4

HAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAS1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M052216: view genomic region (about GC identifiers)

Start:	52,216,365 bp from pter	End:	52,227,227 bp from pter
Size:	10,863 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839 (See protein sequence)

Recommended Name: Hyaluronan synthase 1

Size: 578 amino acids; 64832 Da

Cofactor: Magnesium

Subcellular location: Membrane; Multi-pass membrane protein (Probable)

Sequence caution: Sequence=BAA12351.1; Type=Erroneous initiation;

Secondary accessions: Q14470 Q9NS49

Explore the universe of human proteins at neXtProt for HAS1: NX_Q92839

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92839

4/7 DME Specific Peptides for HAS1 (Q92839) (see all 7)

CISGPLG

GWGTSGR

LLQQFLE

GYATKYT

HAS1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001514.2

ENSEMBL proteins:

ENSP00000445021 ENSP00000222115

Reactome Protein details: Q92839
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HAS1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9169154

HAS1 for ontologies About GeneDecksing

HAS1 Antibody Products:

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	Uscn Antibodies for HAS1
	ThermoFisher Antibodies for HAS1

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	GenScript Custom Assay Services for HAS1
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	Uscn ELISAs and CLIAs for HAS1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HAS1 for domains About GeneDecksing

1 InterPro domain/family:

IPR026107 HAS/NodC

Graphical View of Domain Structure for InterPro Entry Q92839

ProtoNet protein and cluster: Q92839

1 Blocks protein family: IPB001173 Glycosyl transferase

UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839

Similarity: Belongs to the NodC/HAS family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839

Function: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of

chito-oligosaccharide depending on the substrate

Catalytic activity: UDP-alpha-N-acetyl-D-glucosamine +

beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP +

N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent

hyaluronan)

Catalytic activity: UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent

hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent

hyaluronan)

Genatlas biochemistry entry for HAS1:

hyaluronan synthase gene 1

Enzyme Number (IUBMB): EC 2.4.1.212¹ ²

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAS1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HAS1
		SwitchGear 3'UTR luciferase reporter plasmid: HAS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAS1 (see all 7) OriGene shRNA RFP: HAS1 OriGene siRNA: HAS1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HAS1

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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HAS1
		Search LifeMap BioReagents cell lines for HAS1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0050501	hyaluronan synthase activity	IEA	--

HAS1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for HAS1:

Decreased Hepatitis C virus re

Decreased Wnt reporter activit

Decreased viability of wild-ty

Animal Models:
Mouse knock-out Has1^tm1Nita for HAS1
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Has1):

normal

HAS1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/14 pathways (see all 14)
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS I - Hurler syndrome	1.00	MPS IIID - Sanfilippo syndrome D	1.00
Mucopolysaccharidoses	1.00	MPS IX - Natowicz syndrome	1.00
MPS IV - Morquio syndrome A	1.00	MPS II - Hunter syndrome	1.00

HAS1,2,3 mediate the polymerisation of HA

HAS1,2,3 mediate the polymerisation of HA

1.00

Hyaluronan biosynthesis and export

0.75

Disease

Disease

1.00

Metabolism

Metabolism

1.00

Hyaluronan uptake and degradation

Hyaluronan metabolism

0.71

Pathway sources
See GeneCards unified pathways
Show all pathways

5/19 Reactome Pathways for HAS1 (see all 19)

	Hyaluronan metabolism
	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	MPS II - Hunter syndrome

UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839

Pathway: Glycan biosynthesis; hyaluronan biosynthesis

HAS1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HAS1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for HAS1 (Q92839^{1, 3} ENSP00000222115⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF6	P56537¹^,³, ENSP00000363559⁴	EBI-1052423,EBI-372243 I2D: score=2 STRING: ENSP00000363559
VHL	P40337¹^,³, ENSP00000256474⁴	EBI-1052423,EBI-301246 I2D: score=2 STRING: ENSP00000256474
ABCC5	ENSP00000333926⁴	STRING: ENSP00000333926
IFI27	ENSP00000298902⁴	STRING: ENSP00000298902

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006024	glycosaminoglycan biosynthetic process	TAS	8798544
GO:0007155	cell adhesion	TAS	8798544
GO:0010764	negative regulation of fibroblast migration	IMP	19577615
GO:0030203	glycosaminoglycan metabolic process	TAS	--

HAS1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HAS1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HAS1

6 HMDB Compounds for HAS1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Hyaluronan	hyaluronic acid (see all 13)	9004-61-9	--
Hyaluronic acid	hyaluronic acid	9004-61-9	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Uridine 5'-diphosphate	5'-UDP (see all 9)	58-98-0	--
Uridine diphosphate glucuronic acid	UDP glucuronate (see all 41)	2616-64-0	--
Uridine diphosphate-N-acetylglucosamine	N-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)	528-04-1	--

3 Novoseek chemical compound relationships for HAS1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycosaminoglycan	75.5	1	8798544 (1)
hyaluronic acid	64.3	29	17230515 (7), 18768572 (3), 16890679 (1), 19338584 (1) (see all 9)
hydrocortisone	22.1	4	13130151 (2), 10794710 (1)

Search CenterWatch for drugs/clinical trials and news about HAS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HAS1 gene:

NM_001523.2

Unigene Cluster for HAS1:

Hyaluronan synthase 1

Hs.57697 [show with all ESTs]

Unigene Representative Sequence: BC035837

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000540069(uc002pxp.1) ENST00000222115(uc010epc.1 uc010epd.1 uc002pxn.1 uc002pxo.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAS1
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		SwitchGear 3'UTR luciferase reporter plasmid: HAS1 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: HAS1 (NM_001523)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAS1

Additional cDNA sequence:

AM904814.1 AY916555.1 AY916556.1 BC035837.1 D84424.1 U59269.1

3 DOTS entries:

DT.303900 DT.100711622 DT.97833965

21 AceView cDNA sequences:

CR602106 BQ772231 BI753116 AW873943 BG707608 D84424 BC035837 NM_001523

U59269 BQ447523 AL545447 AL571167 BG707429 BM544718 BM543754 BQ002782

BX281117 BF000543 BX327795 CB266804 BM083486

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for HAS1 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:			-										-		-
SP2:			-										-		-
SP3:													-		-
SP4:															-
SP5:											-		-

ECgene alternative splicing isoforms for HAS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HAS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGACGCTGT

About this image
See HAS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HAS1

SOURCE GeneReport for Unigene cluster: Hs.57697

UniProtKB/Swiss-Prot: HAS1_HUMAN, Q92839

Tissue specificity: Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly

expressed in small intestine

SABiosciences Expression via Pathway-Focused PCR Arrays including HAS1:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Drug Metabolism: Phase II Enzymes in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HAS1 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Has1^{1 , 5}	hyaluronan synthase1^{1, 5}	84.72(n)¹ 96.18(a)¹		17 (10.53 cM)⁵ 15116¹ NM_008215.2¹ NP_032241.1¹ 17843328⁵
lizard (Anolis carolinensis)	Reptilia	HAS1⁶ --	--	64(a) 40(a)	1 ↔ 1 possible ortholog	GL343604.1(133819-141486) GL343281.1(1782736-1785594)
zebrafish (Danio rerio)	Actinopterygii	has1¹	hyaluronan synthase 1	61.82(n) 60.64(a)		403130 NM_001164030.1 NP_001157502.1

ENSEMBL Gene Tree for HAS1 (if available)
TreeFam Gene Tree for HAS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HAS1 gene

HAS3² HAS2²

2 SIMAP similar genes for HAS1 using alignment to 7 protein entries: HAS1_HUMAN (see all proteins):

HAS2 HAS3

HAS1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200078680^1,2	C,	other	52220298(+)	`AGTATC/TGCAGG`	2	Q R	mis¹		0	--	--	--	--
rs73054902^1,2	C,	--	52215870(+)	`TGGCAC/TTGGCT`	1	--	ds500¹		5		CSA WA NA EA	361
rs182666046^1,2		--	52215924(+)	`GTGTAC/TGGACA`	1	--	ds500¹		0	--	--	--	--
rs61683178^1,2	C,F,	--	52215974(+)	`CAGCAG/AAAGTT`	1	--	ds500¹		5		NA WA EA	362
rs79956121^1,2	C,	--	52216109(+)	`AGCACC/TATCTG`	1	--	ds500¹		2		NA	122
rs45475696^1,2	C,F,	--	52216154(+)	`TTGGTA/CAGTAC`	1	--	ds500¹		1		NA	120
rs186898017^1,2		--	52216161(+)	`GTACCA/CGTGAA`	1	--	ds500¹		0	--	--	--	--
rs3829654^1,2	C,F,H,	--	52216295(-)	`CAGTGC/GTGGGT`	1	--	ds500¹		15		NS EA NA WA CSA	786
rs3829653^1,2	C,F,A,	--	52216331(-)	`GGGGAA/CTGGAT`	1	--	ds500¹		12		NA WA CSA EA	375
rs3829652^1,2	C,F,	--	52216353(-)	`CCTCCA/TCCTTT`	1	--	ds500¹		4		NA EA	244

HapMap Linkage Disequilibrium report for HAS1 (52216365 - 52227227 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for HAS1
5 CNVs: 78254 30915 34482 89299 4085
Human Gene Mutation Database (HGMD): HAS1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HAS1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HAS1 for disorders           About GeneDecksing

OMIM gene information: 601463    OMIM disorders: --

20/38 diseases for HAS1 (see all 38):    About MalaCards

rheumatoid arthritis arthropathy juvenile hyaline fibromatosis waldenstrom macroglobulinemia

arthritis malignant peritoneal mesothelioma macroglobulinemia fibromatosis

eye disease cystitis graves' disease multiple myeloma

osteoarthritis ovarian cancer peritonitis endometrial carcinoma

nephropathy breast cancer copd noma

1 disease from the University of Copenhagen DISEASES database for HAS1:

Influenza

10 Novoseek disease relationships for HAS1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
waldenstrom macroglobulinemia	63.5	6	18815290 (2), 15794859 (1)
rheumatoid arthritis	21.8	2	15763928 (1), 15535829 (1)
ovarian cancer	20.1	2	15375493 (2)
osteoarthritis	19.1	2	15763928 (1), 15535829 (1)
tumors	7.86	8	14676202 (1), 15763928 (1), 17230515 (1), 17315194 (1) (see all 7)
cancer	2.19	8	19451652 (2), 14566823 (1), 15231668 (1)
necrosis	1.27	2	14676202 (1), 15763928 (1)
inflammation	0	2	18393848 (1), 16904269 (1)
breast cancer	0	3	17315194 (1), 16642399 (1)
carcinoma	0	1	19435493 (1)

Genetic Association Database (GAD): HAS1
Human Genome Epidemiology (HuGE) Navigator: HAS1 (1 document)

Export disorders for HAS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HAS1 gene, integrated from 9 sources (see all 99):
(articles sorted by number of sources associating them with HAS1)

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Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia. (PubMed id 15794859)^{1, 4, 9} Adamia S....Pilarski L.M. (2005)
Chromosomal localization of the human and mouse hyaluronan synthase genes. (PubMed id 9169154)^{1, 3, 9} Spicer A.P....McDonald J.A. (1997)
Functional cloning of the cDNA for a human hyaluronan synthase. (PubMed id 8798544)^{1, 2, 9} Shyjan A.M.... Briskin M.J. (1996)
Molecular cloning of human hyaluronan synthase. (PubMed id 8651928)^{1, 2} Itano N. and Kimata K. (1996)
Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma. (PubMed id 15731173)^{1, 9} Adamia S....Pilarski L.M. (2005)
Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential me chanism promoting human cancer. (PubMed id 19451652)^{1, 9} Ghosh A....Pilarski L.M. (2009)
Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia. (PubMed id 18815290)^{1, 9} Adamia S....Pilarski L.M. (2008)
Adenovirus-mediated gene transfer of mutated IkappaB kinase and IkappaBalpha reveal NF-kappaB-dependent as well as NF-kappaB-independent pathways of HAS1 activation. (PubMed id 16258173)^{1, 9} Stuhlmeier K.M. and Pollaschek C. (2005)
The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1. (PubMed id 16723203)^{1, 9} Kao J.J. (2006)
Genetic abnormalities in WaldenstrAPm's macroglobulinemia. (PubMed id 19362966)^{1, 9} Adamia S....Pilarski L.M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3036	HGNC: 4818	AceView: HAS1	Ensembl:ENSG00000105509	euGenes: HUgn3036
ECgene: HAS1	H-InvDB: HAS1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HAS1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HAS1	Genetics and Cytogenetics in Oncology and Haematology
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/

Intellectual Property for HAS1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HAS1 gene:
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GeneCards and IP:
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