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HAS1 Gene

protein-coding   GIFtS: 63
GCID: GC19M052216

Hyaluronan Synthase 1


(Previous symbol: HAS)
  See HAS1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hyaluronan Synthase 11 2     HA Synthase 12 3
HAS1 2 3     huHAS12
Hyaluronate Synthase 12 3     EC 2.4.1.2123
Hyaluronic Acid Synthase 12 3     HuHAS13

External Ids:    HGNC: 48181   Entrez Gene: 30362   Ensembl: ENSG000001055097   OMIM: 6014635   UniProtKB: Q928393   

Export aliases for HAS1 gene to outside databases

Previous GC identifers: GC19M052846 GC19M052577 GC19M056892 GC19M056908 GC19M048547


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAS1 Gene:
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide
variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of
alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic
bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains
are extruded through pore-like structures into the extracellular space. It serves a variety of functions,
including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is
actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and
fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative
arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44
is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with
tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan
synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus
pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan
synthase. (provided by RefSeq, Jul 2008)

GeneCards Summary for HAS1 Gene:
HAS1 (hyaluronan synthase 1) is a protein-coding gene. Diseases associated with HAS1 include waldenstrom macroglobulinemia, and malignant peritoneal mesothelioma. GO annotations related to this gene include hyaluronan synthase activity. An important paralog of this gene is HAS3.

UniProtKB/Swiss-Prot: HYAS1_HUMAN, Q92839
Function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore,
it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural
role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the
isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the
substrate (By similarity)

Gene Wiki entry for HAS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAS1 gene promoter:
         p53   AP-1   ATF-2   Olf-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAS1 promoter sequence
   Search Chromatin IP Primers for HAS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3-q13.4

HAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAS1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052216:  view genomic region     (about GC identifiers)

Start:
52,216,365 bp from pter      End:
52,227,247 bp from pter
Size:
10,883 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HYAS1_HUMAN, Q92839 (See protein sequence)
Recommended Name: Hyaluronan synthase 1  
Size: 578 amino acids; 64832 Da
Cofactor: Magnesium
Sequence caution: Sequence=BAA12351.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q14470 Q9NS49

Explore the universe of human proteins at neXtProt for HAS1: NX_Q92839

Explore proteomics data for HAS1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HAS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001514.2  
    ENSEMBL proteins: 
     ENSP00000472821   ENSP00000222115   ENSP00000445021   ENSP00000471953   ENSP00000469165  
    Reactome Protein details: Q92839

    HAS1 Human Recombinant Protein Products:

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    Novus Biologicals HAS1 Lysate
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    Cloud-Clone Corp. Proteins for HAS1

     
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    HAS1 Antibody Products:

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    Cloud-Clone Corp. Antibodies for HAS1
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    LSBio Antibodies in human, mouse, rat for HAS1

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    Search eBioscience for ELISAs for HAS1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GLT2: Glycosyltransferase family 2 domain containing

    2 InterPro protein domains:
     IPR026107 HAS/NodC
     IPR028385 HAS1

    Graphical View of Domain Structure for InterPro Entry Q92839

    ProtoNet protein and cluster: Q92839

    1 Blocks protein domain: IPB001173 Glycosyl transferase

    UniProtKB/Swiss-Prot: HYAS1_HUMAN, Q92839
    Similarity: Belongs to the NodC/HAS family


    Find genes that share domains with HAS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYAS1_HUMAN, Q92839
    Function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore,
    it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural
    role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the
    isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the
    substrate (By similarity)
    Catalytic activity: UDP-alpha-N-acetyl-D-glucosamine +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP +
    N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent
    hyaluronan)
    Catalytic activity: UDP-alpha-D-glucuronate +
    N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)

         Genatlas biochemistry entry for HAS1:
    hyaluronan synthase gene 1

         Enzyme Number (IUBMB): EC 2.4.1.2121

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050501hyaluronan synthase activity ISS--
         
    Find genes that share ontologies with HAS1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HAS1:
     Decreased Hepatitis C virus re  Decreased Wnt reporter activit  Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Has1):
     normal 

    Find genes that share phenotypes with HAS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Has1tm1Nita for HAS1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HAS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAS1

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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: HAS1 (NM_001523)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAS1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HYAS1_HUMAN, Q92839: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    golgi apparatus3
    extracellular2
    endoplasmic reticulum1
    endosome1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9169154
    GO:0016020membrane ----

    Find genes that share ontologies with HAS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HAS1 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Metabolism
    Metabolism0.38
    3Disease
    Disease


    Find genes that share SuperPaths with HAS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for HAS1
        Hyaluronan biosynthesis and export


    UniProtKB/Swiss-Prot: HYAS1_HUMAN, Q92839
    Pathway: Glycan biosynthesis; hyaluronan biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HAS1: 

              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HAS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HAS1 (Q928391, 3 ENSP000002221154) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF6P565371, 3, ENSP000003635594EBI-1052423,EBI-372243 I2D: score=2 STRING: ENSP00000363559
    VHLP403371, 3, ENSP000002564744EBI-1052423,EBI-301246 I2D: score=2 STRING: ENSP00000256474
    ABCC5ENSP000003339264STRING: ENSP00000333926
    KYENSP000003975984STRING: ENSP00000397598
    UPF2ENSP000003487084STRING: ENSP00000348708
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS8798544
    GO:0007155cell adhesion TAS8798544
    GO:0010764negative regulation of fibroblast migration IMP19577615
    GO:0030203glycosaminoglycan metabolic process TAS--

    Find genes that share ontologies with HAS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HAS1 (HYAS1)

    6 HMDB Compounds for HAS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronanhyaluronic acid (see all 13)9004-61-9--
    Hyaluronic acidhyaluronic acid 9004-61-9--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--

    3 Novoseek inferred chemical compound relationships for HAS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycosaminoglycan 75.5 1 8798544 (1)
    hyaluronic acid 64.3 29 17230515 (7), 18768572 (3), 16890679 (1), 19338584 (1) (see all 9)
    hydrocortisone 22.1 4 13130151 (2), 10794710 (1)



    Find genes that share compounds with HAS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HAS1 gene: 
    NM_001523.2  

    Unigene Cluster for HAS1:

    Hyaluronan synthase 1
    Hs.57697  [show with all ESTs]
    Unigene Representative Sequence: BC035837
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601714 ENST00000222115(uc010epc.1 uc010epd.1 uc002pxn.1 uc002pxo.1)
    ENST00000540069(uc002pxp.1) ENST00000601667 ENST00000594621
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      QuantiFast Probe-based Assays in human, mouse, rat HAS1

    Additional mRNA sequence: 

    AM904814.1 AY916555.1 AY916556.1 BC035837.1 D84424.1 U59269.1 

    3 DOTS entries:

    DT.303900  DT.100711622  DT.97833965 

    21 AceView cDNA sequences:

    CR602106 BQ772231 NM_001523 BM543754 BG707429 U59269 BC035837 AL545447 
    AL571167 AW873943 D84424 BG707608 BM544718 BI753116 BQ447523 CB266804 
    BF000543 BX281117 BM083486 BX327795 BQ002782 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HAS1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:        -                             -     -               
    SP2:        -                             -     -               
    SP3:                                      -     -               
    SP4:                                            -               
    SP5:                                -     -                     


    ECgene alternative splicing isoforms for HAS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HAS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGACGCTGT
    HAS1 Expression
    About this image


    HAS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Pancreas (Endocrine System)
    HAS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HAS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.57697

    UniProtKB/Swiss-Prot: HYAS1_HUMAN, Q92839
    Tissue specificity: Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and
    large intestine. Weakly expressed in small intestine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HAS1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for HAS1
    OriGene qSTAR qPCR primer pairs in human, mouse for HAS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAS1
    Search QuantiTect SYBR Green Assays in human, mouse, rat HAS1
    QuantiFast Probe-based Assays in human, mouse, rat HAS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HAS1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Has11 , 5 hyaluronan synthase11, 5 84.43(n)1
    95.31(a)1
      17 (10.53 cM)5
    151161  NM_008215.21  NP_032241.11 
     178433285 
    lizard
    (Anolis carolinensis)
    Reptilia HAS16
    hyaluronan synthase 1
    63(a)
    1 ↔ 1
    GL343604.1(95461-142605)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004916731 hyaluronan synthase 1-like 61.78(n)
    62.57(a)
      100491673  XM_002937916.2  XP_002937962.1 
    zebrafish
    (Danio rerio)
    Actinopterygii has11 hyaluronan synthase 1 61.94(n)
    60.82(a)
      403130  NM_001164030.1  NP_001157502.1 


    ENSEMBL Gene Tree for HAS1 (if available)
    TreeFam Gene Tree for HAS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HAS1 gene
    HAS32  HAS22  
    2 SIMAP similar genes for HAS1 using alignment to 7 protein entries:     HYAS1_HUMAN (see all proteins):
    HAS2    HAS3

    Find genes that share paralogs with HAS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HAS1 (see all 356)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2000786801,2
    Cuntested152220298(+) AGTATC/TGCAGG 2 Q R mis10--------
    rs730549021,2
    C--52215870(+) TGGCAC/TTGGCT 1 -- ds50015Minor allele frequency- T:0.09CSA WA NA EA 361
    rs1826660461,2
    --52215924(+) GTGTAC/TGGACA 1 -- ds50010--------
    rs616831781,2
    C,F--52215974(+) CAGCAG/AAAGTT 1 -- ds50015Minor allele frequency- A:0.10NA WA EA 362
    rs799561211,2
    C,F--52216109(+) AGCACC/TATCTG 1 -- ds50012Minor allele frequency- T:0.08NA 122
    rs454756961,2
    C,F--52216154(+) TTGGTA/CAGTAC 1 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1868980171,2
    --52216161(+) GTACCA/CGTGAA 1 -- ds50010--------
    rs38296541,2
    C,F,H--52216295(-) CAGTGC/GTGGGT 1 -- ds500115Minor allele frequency- G:0.33NS EA NA WA CSA 786
    rs38296531,2
    C,F,A--52216331(-) GGGGAA/CTGGAT 1 -- ds500112Minor allele frequency- C:0.47NA WA CSA EA 375
    rs38296521,2
    C,F--52216353(-) CCTCCA/TCCTTT 1 -- ds50014Minor allele frequency- T:0.07NA EA 244

    HapMap Linkage Disequilibrium report for HAS1 (52216365 - 52227247 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HAS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912296CNV Loss21882294
    nsv912297CNV Loss21882294
    nsv458733CNV Gain19166990
    nsv524403CNV Gain19592680
    nsv470151CNV Gain18288195
    nsv9742CNV Gain+Loss18304495
    esv638CNV CNV17122850
    dgv1109e1CNV Complex17122850
    dgv1110e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): HAS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HAS1
    DNA2.0 Custom Variant and Variant Library Synthesis for HAS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601463    OMIM disorders: --

    6 diseases for HAS1:    
    About MalaCards
    waldenstrom macroglobulinemia    malignant peritoneal mesothelioma    peritoneal mesothelioma    macroglobulinemia
    juvenile hyaline fibromatosis    rheumatoid arthritis

    1 disease from the University of Copenhagen DISEASES database for HAS1:
    Influenza

    Find genes that share disorders with HAS1           About GenesLikeMe

    10 Novoseek inferred disease relationships for HAS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    waldenstrom macroglobulinemia 63.5 6 18815290 (2), 15794859 (1)
    rheumatoid arthritis 21.8 2 15763928 (1), 15535829 (1)
    ovarian cancer 20.1 2 15375493 (2)
    osteoarthritis 19.1 2 15763928 (1), 15535829 (1)
    tumors 7.86 8 14676202 (1), 15763928 (1), 17230515 (1), 17315194 (1) (see all 7)
    cancer 2.19 8 19451652 (2), 14566823 (1), 15231668 (1)
    necrosis 1.27 2 14676202 (1), 15763928 (1)
    inflammation 0 2 18393848 (1), 16904269 (1)
    breast cancer 0 3 17315194 (1), 16642399 (1)
    carcinoma 0 1 19435493 (1)

    Genetic Association Database (GAD): HAS1
    Human Genome Epidemiology (HuGE) Navigator: HAS1 (1 document)

    Export disorders for HAS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HAS1 gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with HAS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia. (PubMed id 15794859)1, 4, 9 Adamia S....Pilarski L.M. (Clin Lymphoma 2005)
    2. Chromosomal localization of the human and mouse hyaluronan synthase genes. (PubMed id 9169154)1, 3, 9 Spicer A.P....McDonald J.A. (Genomics 1997)
    3. Functional cloning of the cDNA for a human hyaluronan synthase. (PubMed id 8798544)1, 2, 9 Shyjan A.M.... Briskin M.J. (J. Biol. Chem. 1996)
    4. Molecular cloning of human hyaluronan synthase. (PubMed id 8651928)1, 2 Itano N. and Kimata K. (Biochem. Biophys. Res. Commun. 1996)
    5. Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma. (PubMed id 15731173)1, 9 Adamia S....Pilarski L.M. (Blood 2005)
    6. Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancer. (PubMed id 19451652)1, 9 Ghosh A....Pilarski L.M. (J. Biol. Chem. 2009)
    7. Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia. (PubMed id 18815290)1, 9 Adamia S....Pilarski L.M. (Blood 2008)
    8. Adenovirus-mediated gene transfer of mutated IkappaB kinase and IkappaBalpha reveal NF-kappaB-dependent as well as NF-kappaB-independent pathways of HAS1 activation. (PubMed id 16258173)1, 9 Stuhlmeier K.M. and Pollaschek C. (J. Biol. Chem. 2005)
    9. The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1. (PubMed id 16723203)1, 9 Kao J.J. (Exp. Gerontol. 2006)
    10. Genetic abnormalities in WaldenstrAPm's macroglobulinemia. (PubMed id 19362966)1, 9 Adamia S....Pilarski L.M. (amp 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3036 HGNC: 4818 AceView: HAS1 Ensembl:ENSG00000105509 euGenes: HUgn3036
    ECgene: HAS1 H-InvDB: HAS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HAS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HAS1 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=HAS1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HAS1 gene:
    Search GeneIP for patents involving HAS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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