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Aliases for HARS2 Gene

Aliases for HARS2 Gene

  • Histidyl-TRNA Synthetase 2, Mitochondrial 2 3
  • EC 4 63
  • HisRS 3 4
  • HARSL 3 4
  • HARSR 3 4
  • HO3 3 4
  • Histidyl-TRNA Synthetase 2, Mitochondrial (Putative) 3
  • Histidine TRNA Ligase 2, Mitochondrial (Putative) 3
  • Probable Histidyl-TRNA Synthetase, Mitochondrial 3
  • Histidyl-TRNA Synthetase-Like 2
  • Histidine-TRNA Ligase Homolog 3
  • Histidine--TRNA Ligase-Like 4
  • Mitochondrial (Putative) 2
  • Histidyl-TRNA Synthetase 4
  • Histidine TRNA Ligase 2 2
  • Histidine Translase 3
  • HARS-Related 3
  • EC 6.1.1 63
  • PRLTS2 3

External Ids for HARS2 Gene

Previous HGNC Symbols for HARS2 Gene


Previous GeneCards Identifiers for HARS2 Gene

  • GC20P018556
  • GC20P018563
  • GC20P018516
  • GC05P140053
  • GC05P135216
  • GC05P140088
  • GC05P140095
  • GC05P140110
  • GC05P141419

Summaries for HARS2 Gene

Entrez Gene Summary for HARS2 Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for HARS2 Gene

HARS2 (Histidyl-TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with HARS2 include perrault syndrome and perrault syndrome 2. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include poly(A) RNA binding and aminoacyl-tRNA ligase activity. An important paralog of this gene is HARS.

Gene Wiki entry for HARS2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HARS2 Gene

Genomics for HARS2 Gene

Regulatory Elements for HARS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HARS2 Gene

140,691,426 bp from pter
140,699,318 bp from pter
7,893 bases
Plus strand

Genomic View for HARS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HARS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HARS2 Gene

Proteins for HARS2 Gene

  • Protein details for HARS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable histidine--tRNA ligase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B4DDY8

    Protein attributes for HARS2 Gene

    506 amino acids
    Molecular mass:
    56888 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for HARS2 Gene


neXtProt entry for HARS2 Gene

Proteomics data for HARS2 Gene at MOPED

Post-translational modifications for HARS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for HARS2 Gene

Gene Families for HARS2 Gene

Protein Domains for HARS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-II aminoacyl-tRNA synthetase family.
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with HARS2: view

Function for HARS2 Gene

Molecular function for HARS2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

Enzyme Numbers (IUBMB) for HARS2 Gene

Gene Ontology (GO) - Molecular Function for HARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004821 histidine-tRNA ligase activity NAS 7755634
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HARS2: view

Phenotypes for HARS2 Gene

GenomeRNAi human phenotypes for HARS2:
genes like me logo Genes that share phenotypes with HARS2: view

Animal Model Products

miRNA for HARS2 Gene

miRTarBase miRNAs that target HARS2

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for HARS2 Gene

Localization for HARS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HARS2 Gene

Mitochondrion matrix.

Subcellular locations from

Jensen Localization Image for HARS2 Gene COMPARTMENTS Subcellular localization image for HARS2 gene
Compartment Confidence
mitochondrion 4
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for HARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IDA 21464306
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with HARS2: view

Pathways & Interactions for HARS2 Gene

genes like me logo Genes that share pathways with HARS2: view

Pathways by source for HARS2 Gene

1 KEGG pathway for HARS2 Gene

Gene Ontology (GO) - Biological Process for HARS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 7755634
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006427 histidyl-tRNA aminoacylation IDA 21464306
GO:0010467 gene expression TAS --
GO:0032543 NOT mitochondrial translation IBA --
genes like me logo Genes that share ontologies with HARS2: view

No data available for SIGNOR curated interactions for HARS2 Gene

Drugs & Compounds for HARS2 Gene

(4) Drugs for HARS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
L-Histidine Approved Nutra 0
Diphosphate Experimental Pharma 0

(2) Additional Compounds for HARS2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
genes like me logo Genes that share compounds with HARS2: view

Transcripts for HARS2 Gene

Unigene Clusters for HARS2 Gene

Histidyl-tRNA synthetase 2, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HARS2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - -
SP6: -
SP7: - - - - - -
SP8: - - -
SP9: - -
SP10: - -

Relevant External Links for HARS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HARS2 Gene

mRNA expression in normal human tissues for HARS2 Gene

Protein differential expression in normal tissues from HIPED for HARS2 Gene

This gene is overexpressed in Heart (10.8) and Lung (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HARS2 Gene

SOURCE GeneReport for Unigene cluster for HARS2 Gene Hs.432560

mRNA Expression by UniProt/SwissProt for HARS2 Gene

Tissue specificity: A high level expression is seen in the heart, kidney and skeletal muscle while a lower level expression is seen in the brain and liver
genes like me logo Genes that share expression patterns with HARS2: view

Protein tissue co-expression partners for HARS2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HARS2 Gene

Orthologs for HARS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HARS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HARS2 35
  • 89.66 (n)
  • 88.93 (a)
HARS2 36
  • 89 (a)
(Canis familiaris)
Mammalia HARS2 35
  • 88.45 (n)
  • 87.72 (a)
HARS2 36
  • 88 (a)
(Mus musculus)
Mammalia Hars2 35
  • 84.99 (n)
  • 84.52 (a)
Hars2 16
Hars2 36
  • 84 (a)
(Pan troglodytes)
Mammalia HARS2 35
  • 99.8 (n)
  • 100 (a)
HARS2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hars2 35
  • 85.24 (n)
  • 83.79 (a)
(Monodelphis domestica)
Mammalia HARS2 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia HARS2 36
  • 66 (a)
(Gallus gallus)
Aves HARS2 35
  • 71.13 (n)
  • 71.65 (a)
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488813 35
  • 71.65 (n)
  • 73.75 (a)
(Danio rerio)
Actinopterygii hars 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aats-his 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea hars-1 36
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HTS1 36
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8844 36
  • 59 (a)
Species with no ortholog for HARS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HARS2 Gene

Gene Tree for HARS2 (if available)
Gene Tree for HARS2 (if available)

Paralogs for HARS2 Gene

Paralogs for HARS2 Gene

(2) SIMAP similar genes for HARS2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with HARS2: view

Variants for HARS2 Gene

Sequence variations from dbSNP and Humsavar for HARS2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_069532 Perrault syndrome 2 (PRLTS2)
VAR_069533 Perrault syndrome 2 (PRLTS2)

Structural Variations from Database of Genomic Variants (DGV) for HARS2 Gene

Variant ID Type Subtype PubMed ID
nsv830508 CNV Loss 17160897

Variation tolerance for HARS2 Gene

Residual Variation Intolerance Score: 27.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HARS2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HARS2 Gene

Disorders for HARS2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HARS2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
perrault syndrome
  • gonadal dysgenesis xx type deafness
perrault syndrome 2
  • prlts2
- elite association
Search HARS2 in MalaCards View complete list of genes associated with diseases


  • Perrault syndrome 2 (PRLTS2) [MIM:614926]: A sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Affected females have primary amenorrhea, streak gonads, and infertility, whereas affected males show normal pubertal development and are fertile. {ECO:0000269 PubMed:21464306}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HARS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HARS2: view

No data available for Genatlas for HARS2 Gene

Publications for HARS2 Gene

  1. Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. (PMID: 21464306) Pierce S.B. … King M.C. (Proc. Natl. Acad. Sci. U.S.A. 2011) 2 67
  2. Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. (PMID: 20132829) Merritt E.A. … Hol W.G. (J. Mol. Biol. 2010) 23 67
  3. Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2. (PMID: 15964839) Padyana A.K. … Burley S.K. (J. Biol. Chem. 2005) 23 67
  4. Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog. (PMID: 16051603) Champagne K.S. … Francklyn C.S. (J. Biol. Chem. 2005) 23 67
  5. Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain. (PMID: 10983975) Dong J. … Hinnebusch A.G. (Mol. Cell 2000) 23 67

Products for HARS2 Gene

Sources for HARS2 Gene

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