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Aliases & Descriptions for HARS2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.1.1.21 3 | | HARS-related 2 | | HARSL 2, 3 | | HARSR 1, 2, 3 | | HO3 1, 2, 3 | | HisRS 3 | | hisRS 2 |
| | | Descriptions |
|---|
| Histidine--tRNA ligase 3 | | Histidine--tRNA ligase-like 3 | | histidine tRNA ligase 2, mitochondrial (putative) 2 | | histidine translase 2 | | histidine-tRNA ligase homolog 2 | | histidyl-tRNA synthetase 2 2 | | histidyl-tRNA synthetase 2, mitochondrial (putative) 2 | | histidyl-tRNA synthetase-like 1, 2 |
|
| | Search outside databases for aliases for HARS2 genePrevious GC identifers: GC20P018556 GC20P018563 GC20P018516 |
Summaries for HARS2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HARS2: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter. [provided by RefSeq] Gene Wiki entry for HARS2 |
Genomic Location for HARS2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HARS2 gene 
Entrez Gene cytogenetic band: 5q31.3 Ensembl cytogenetic band: 20p11.23 HGNC cytogenetic band: 5q31.3HARS2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P140053:
(about GC identifiers)
Start:
|
140,051,202 bp from pter |
End:
|
140,059,074 bp from pter |
Size:
|
7,873 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr20+ 18,516,556-18,692,561 |
RefSeq DNA sequence:- NC_000005.8 NT_029289.10
| Proteins for HARS2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYHM_HUMAN, P49590 (See
protein sequence)Recommended Name: Probable histidyl-tRNA synthetase, mitochondrial precursor Size: 506 amino acids; 56888 Da
Subcellular location: Mitochondrion matrix (By similarity)Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_036340.1
ENSEMBL proteins: ENSP00000366672
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: HARS2 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HARS2: Assays for HARS2: | Protein
Domains/ Families for HARS2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P49590
ProtoNet protein and cluster: P49590 UniProtKB/Swiss-Prot: SYHM_HUMAN, P49590Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family | Gene Function for HARS2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012208
Applied Biosystems Silencer® siRNAs for HARS2
Sigma-Aldrich siRNA for HARS2  Sigma-Aldrich shRNA for HARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012208                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012208                                  untagged cDNA clone in CMV expression vector: NM_012208 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012208
UniProtKB/Swiss-Prot: SYHM_HUMAN, P49590Catalytic activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)Enzyme Number (IUBMB): EC 6.1.1.21 4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for HARS2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for HARS2 (Your Favorite Gene powered by Ingenuity) 
1 Interacting protein for HARS2 (ENSP000003666723) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006427 | histidyl-tRNA aminoacylation |
IEA | -- | About this table
|
Drugs & Compounds for HARS2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for HARS2 1 Novoseek chemical compound relationship for HARS2 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| trna |
65.59 |
4 |
10983975 (2), 15964839 (1) |
About this table
|
Transcripts for HARS2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012208
Sigma-Aldrich siRNA for HARS2  Sigma-Aldrich shRNA for HARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012208 REFSEQ mRNAs for HARS2 gene: NM_012208.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012208               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012208                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012208                                  untagged cDNA clone in CMV expression vector: NM_012208  Additional cDNA sequence: AK293269.1 AK293390.1 AK298661.1 AK299971.1 AK309832.1 AK311277.1 AK312976.1 BC007680.2 BC014982.1 CR613950.1 CR617548.1 U18937.1 11 DOTS entries: DT.115301 DT.100814557 DT.91764616 DT.120887688 DT.120887546 DT.452906 DT.100814561 DT.95120098 DT.91764613 DT.95103823 DT.91764610 24/532 AceView cDNA sequences (see all 532
):BM719770 BU184708 AW029120 CD678311 AA513710 BU930888 BF796500 BF980999 BC014982 BX114048 BI915706 BQ433633 BM970051 AJ712800 AA496355 BM794321 BQ224071 AA708623 R73183 BU656872 BQ060977 AI383091 CA421132 BU193977
highest scoring ESTs for HARS2:AA076232 AA076233 AA280809 AA476629 AA602981 AA679795 AI189980 AI203033 AI214277 AI224558 Unigene Cluster for HARS2: Histidyl-tRNA synthetase 2, mitochondrial (putative) Hs.432560 [show with all ESTs]Unigene Representative Sequence: NM_012208
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000377452
|
Expression for HARS2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HARS2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HARS2
1 / 2 / 3 3 probe-sets matching HARS2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTAAATAAAA
SOURCE GeneReport for Unigene cluster: Hs.432560 UniProtKB/Swiss-Prot: SYHM_HUMAN, P49590Tissue specificity: A high level expression is seen in the heart, kidney and skeletal muscle while a lower level expression is seen in the brain and liver |
Orthologs for HARS2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HARS2 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for HARS2
ENSEMBL Gene Tree for HARS2 | Paralogs for HARS2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for HARS2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HARS2 (up to first 250kb)
|
Disorders & Mutations for HARS2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600783
|
Medical News for HARS2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HARS2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for HARS2 gene (see all 12
): |
Search for HARS2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HARS2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HARS2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HARS2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HARS2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HARS2:

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Incremental update: 13 Oct 2009
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