Aliases for HARS Gene
External Ids for HARS Gene
Previous GeneCards Identifiers for HARS Gene
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for HARS Gene
HARS (Histidyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with HARS include Usher Syndrome Type 3B and Charcot-Marie-Tooth Disease, Axonal, Type 2W. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include nucleotide binding and histidine-tRNA ligase activity. An important paralog of this gene is HARS2.
UniProtKB/Swiss-Prot for HARS Gene
Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance.