Aliases for HARS Gene
External Ids for HARS Gene
Previous GeneCards Identifiers for HARS Gene
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for HARS Gene
HARS (Histidyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with HARS include usher syndrome type 3b and antisynthetase syndrome. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include histidine-tRNA ligase activity. An important paralog of this gene is HARS2.