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Aliases for HARBI1 Gene

Aliases for HARBI1 Gene

  • Harbinger Transposase Derived 1 2 3 5
  • Harbinger Transposase-Derived Nuclease 3 4
  • C11orf77 3 4
  • Chromosome 11 Open Reading Frame 77 2
  • Putative Nuclease HARBI1 3
  • EC 3.1.-.- 4

External Ids for HARBI1 Gene

Previous HGNC Symbols for HARBI1 Gene

  • C11orf77

Previous GeneCards Identifiers for HARBI1 Gene

  • GC11M046583
  • GC11M046331
  • GC11M046672
  • GC11M048067
  • GC11M048792
  • GC11M049891
  • GC11M047079
  • GC11M047924
  • GC11M050780
  • GC11M051575

Summaries for HARBI1 Gene

GeneCards Summary for HARBI1 Gene

HARBI1 (Harbinger Transposase Derived 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on ester bonds and nuclease activity.

UniProtKB/Swiss-Prot for HARBI1 Gene

  • Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HARBI1 Gene

Genomics for HARBI1 Gene

Regulatory Elements for HARBI1 Gene

Enhancers for HARBI1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F046639 0.7 ENCODE 12 -22.5 -22451 2.4 SOX13 ELF3 ZNF792 SAP130 MAX TEAD3 ZNF664 HNF4G NFE2 CREM ZNF408 ATG13 HARBI1 AMBRA1 F2 ARHGAP1 SNORD67 CKAP5 GC11M052634
GH11F046559 0.7 Ensembl ENCODE 12 +57.0 56991 3.4 HDGF KLF1 IRF2 PKNOX1 ZNF366 STAT2 ADNP PRDM10 ZNF600 STAT1 ATG13 AMBRA1 HARBI1 CHRM4 MDK DGKZ MIR3160-1
GH11F046597 1.2 Ensembl ENCODE 11.6 +20.1 20121 1.5 PKNOX1 ATF1 ARID4B GATA2 FOS NCOA1 PPARG MBD2 MEF2D MIER3 HARBI1 CHRM4 ARHGAP1 ZNF408 AMBRA1 ATG13
GH11F046647 1.2 Ensembl ENCODE 11.6 -31.3 -31328 2.8 CTCF NFIA JUN SIN3A RAD21 ATF2 NR2F2 JUND POLR2A ZBTB48 ATG13 ARHGAP1 ZNF408 HARBI1 F2 AMBRA1 CHRM4 SNORD67 CKAP5 LRP4
GH11F046552 0.9 Ensembl ENCODE 11.6 +62.3 62314 5.6 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 SLC30A9 FOS SP5 ATG13 AMBRA1 HARBI1 CHRM4 MDK DGKZ C11orf49 ZNF408 MIR3160-1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HARBI1 on UCSC Golden Path with GeneCards custom track

Promoters for HARBI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108991 9 2601 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 SP5

Genomic Location for HARBI1 Gene

Chromosome:
11
Start:
46,602,861 bp from pter
End:
46,617,909 bp from pter
Size:
15,049 bases
Orientation:
Minus strand

Genomic View for HARBI1 Gene

Genes around HARBI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HARBI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HARBI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HARBI1 Gene

Proteins for HARBI1 Gene

  • Protein details for HARBI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MB7-HARB1_HUMAN
    Recommended name:
    Putative nuclease HARBI1
    Protein Accession:
    Q96MB7
    Secondary Accessions:
    • D3DQP9

    Protein attributes for HARBI1 Gene

    Size:
    349 amino acids
    Molecular mass:
    39146 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Interacts with NAIF1.

neXtProt entry for HARBI1 Gene

Post-translational modifications for HARBI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HARBI1 Gene

Domains & Families for HARBI1 Gene

Protein Domains for HARBI1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HARBI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MB7

UniProtKB/Swiss-Prot:

HARB1_HUMAN :
  • Contains 1 DDE Tnp4 domain.
  • Belongs to the HARBI1 family.
Domain:
  • Contains 1 DDE Tnp4 domain.
Family:
  • Belongs to the HARBI1 family.
genes like me logo Genes that share domains with HARBI1: view

No data available for Gene Families for HARBI1 Gene

Function for HARBI1 Gene

Molecular function for HARBI1 Gene

UniProtKB/Swiss-Prot Function:
Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

Enzyme Numbers (IUBMB) for HARBI1 Gene

Gene Ontology (GO) - Molecular Function for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HARBI1: view

Phenotypes for HARBI1 Gene

genes like me logo Genes that share phenotypes with HARBI1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HARBI1 Gene

Localization for HARBI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HARBI1 Gene

Nucleus. Cytoplasm. Note=Interaction with NAIF1 promotes translocation to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HARBI1 Gene COMPARTMENTS Subcellular localization image for HARBI1 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with HARBI1: view

Pathways & Interactions for HARBI1 Gene

SuperPathways for HARBI1 Gene

No Data Available

Interacting Proteins for HARBI1 Gene

Gene Ontology (GO) - Biological Process for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with HARBI1: view

No data available for Pathways by source and SIGNOR curated interactions for HARBI1 Gene

Transcripts for HARBI1 Gene

mRNA/cDNA for HARBI1 Gene

Unigene Clusters for HARBI1 Gene

Harbinger transposase derived 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HARBI1 Gene

No ASD Table

Relevant External Links for HARBI1 Gene

GeneLoc Exon Structure for
HARBI1
ECgene alternative splicing isoforms for
HARBI1

Expression for HARBI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HARBI1 Gene

mRNA differential expression in normal tissues according to GTEx for HARBI1 Gene

This gene is overexpressed in Testis (x5.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HARBI1 Gene



NURSA nuclear receptor signaling pathways regulating expression of HARBI1 Gene:

HARBI1

SOURCE GeneReport for Unigene cluster for HARBI1 Gene:

Hs.714463

mRNA Expression by UniProt/SwissProt for HARBI1 Gene:

Q96MB7-HARB1_HUMAN
Tissue specificity: Detected in brain, eye, nerve tissue, kidney and lung.
genes like me logo Genes that share expression patterns with HARBI1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for HARBI1 Gene

Orthologs for HARBI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HARBI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HARBI1 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia HARBI1 34 35
  • 93.03 (n)
cow
(Bos Taurus)
Mammalia HARBI1 34 35
  • 91.31 (n)
oppossum
(Monodelphis domestica)
Mammalia HARBI1 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Harbi1 34
  • 88.25 (n)
mouse
(Mus musculus)
Mammalia Harbi1 34 16 35
  • 87.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HARBI1 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves HARBI1 34 35
  • 76.72 (n)
lizard
(Anolis carolinensis)
Reptilia HARBI1 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493758 34
  • 68.59 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26314 34
zebrafish
(Danio rerio)
Actinopterygii harbi1 34 35
  • 63.79 (n)
Dr.15651 34
fruit fly
(Drosophila melanogaster)
Insecta CG43088 35
  • 16 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G55350 34
  • 41.51 (n)
rice
(Oryza sativa)
Liliopsida Os01g0838900 34
  • 43.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
Species where no ortholog for HARBI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HARBI1 Gene

ENSEMBL:
Gene Tree for HARBI1 (if available)
TreeFam:
Gene Tree for HARBI1 (if available)

Paralogs for HARBI1 Gene

No data available for Paralogs for HARBI1 Gene

Variants for HARBI1 Gene

Sequence variations from dbSNP and Humsavar for HARBI1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11038934 -- 46,603,485(+) GAAAG(G/T)CTGTC utr-variant-3-prime
rs11038935 -- 46,609,711(+) GCTGA(C/G)CAGGC intron-variant
rs11038936 -- 46,609,994(+) ACTAC(A/C)AGTGC intron-variant
rs111664303 -- 46,608,765(+) CATGC(A/G)CCACC intron-variant
rs111726351 -- 46,608,128(+) GCCCC(A/G)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HARBI1 Gene

Variant ID Type Subtype PubMed ID
esv3387485 CNV insertion 20981092
esv993220 OTHER inversion 20482838

Variation tolerance for HARBI1 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HARBI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HARBI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HARBI1 Gene

Disorders for HARBI1 Gene

Relevant External Links for HARBI1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HARBI1

No disorders were found for HARBI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HARBI1 Gene

Publications for HARBI1 Gene

  1. Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PMID: 18339812) Sinzelle L. … Ivics Z. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 4 64
  2. Harbinger transposons and an ancient HARBI1 gene derived from a transposase. (PMID: 15169610) Kapitonov V.V. … Jurka J. (DNA Cell Biol. 2004) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. (PMID: 20694011) Ferreira R.C. … HammarstrAPm L. (Nat. Genet. 2010) 3 64

Products for HARBI1 Gene

Sources for HARBI1 Gene

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