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Aliases for HARBI1 Gene

Aliases for HARBI1 Gene

  • Harbinger Transposase Derived 1 2 3 5
  • Harbinger Transposase-Derived Nuclease 3 4
  • C11orf77 3 4
  • Chromosome 11 Open Reading Frame 77 2
  • Putative Nuclease HARBI1 3
  • EC 3.1.-.- 4

External Ids for HARBI1 Gene

Previous HGNC Symbols for HARBI1 Gene

  • C11orf77

Previous GeneCards Identifiers for HARBI1 Gene

  • GC11M046583
  • GC11M046331
  • GC11M046672
  • GC11M048067
  • GC11M048792
  • GC11M049891
  • GC11M047079
  • GC11M047924
  • GC11M050780
  • GC11M051575
  • GC11M052237
  • GC11M052897

Summaries for HARBI1 Gene

GeneCards Summary for HARBI1 Gene

HARBI1 (Harbinger Transposase Derived 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on ester bonds and nuclease activity.

UniProtKB/Swiss-Prot for HARBI1 Gene

  • Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

Additional gene information for HARBI1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HARBI1 Gene

Genomics for HARBI1 Gene

Regulatory Elements for HARBI1 Gene

Enhancers for HARBI1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H046552 1.4 Ensembl ENCODE 11.6 +62.3 62284 5.5 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 SLC30A9 FOS ATG13 AMBRA1 HARBI1 CHRM4 MDK DGKZ C11orf49 ZNF408 MIR3160-1
GH11H046647 1.2 Ensembl ENCODE dbSUPER 11.7 -31.3 -31328 2.8 NFIA JUN RAD21 ATF2 NR2F2 JUND POLR2A ZBTB48 ZNF629 HNF4A ATG13 ZNF408 ARHGAP1 HARBI1 F2 AMBRA1 CHRM4 SNORD67 CKAP5 LRP4
GH11H046639 1 ENCODE dbSUPER 12 -22.5 -22451 2.4 ELF3 SOX13 FOXA2 ZNF792 SAP130 MAX TEAD3 ZNF664 POLR2A HNF4G ZNF408 ATG13 HARBI1 AMBRA1 F2 ARHGAP1 SNORD67 CKAP5 GC11M053969
GH11H046559 1 Ensembl ENCODE 12 +56.9 56858 3.2 HDGF PKNOX1 IRF2 ETV1 SIN3A ZBTB40 ZNF366 ADNP STAT2 ZNF600 ATG13 AMBRA1 HARBI1 CHRM4 MDK DGKZ MIR3160-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HARBI1 on UCSC Golden Path with GeneCards custom track

Promoters for HARBI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039574 209 2201 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 SP3

Genomic Locations for HARBI1 Gene

Genomic Locations for HARBI1 Gene
15,049 bases
Minus strand

Genomic View for HARBI1 Gene

Genes around HARBI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HARBI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HARBI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HARBI1 Gene

Proteins for HARBI1 Gene

  • Protein details for HARBI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative nuclease HARBI1
    Protein Accession:
    Secondary Accessions:
    • D3DQP9

    Protein attributes for HARBI1 Gene

    349 amino acids
    Molecular mass:
    39146 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Interacts with NAIF1.

neXtProt entry for HARBI1 Gene

Post-translational modifications for HARBI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HARBI1 Gene

Domains & Families for HARBI1 Gene

Gene Families for HARBI1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HARBI1 Gene


Suggested Antigen Peptide Sequences for HARBI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HARBI1 family.
  • Belongs to the HARBI1 family.
genes like me logo Genes that share domains with HARBI1: view

Function for HARBI1 Gene

Molecular function for HARBI1 Gene

UniProtKB/Swiss-Prot Function:
Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

Enzyme Numbers (IUBMB) for HARBI1 Gene

Phenotypes From GWAS Catalog for HARBI1 Gene

Gene Ontology (GO) - Molecular Function for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HARBI1: view

Phenotypes for HARBI1 Gene

genes like me logo Genes that share phenotypes with HARBI1: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HARBI1 Gene

Localization for HARBI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HARBI1 Gene

Nucleus. Cytoplasm. Note=Interaction with NAIF1 promotes translocation to the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HARBI1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with HARBI1: view

Pathways & Interactions for HARBI1 Gene

SuperPathways for HARBI1 Gene

No Data Available

Interacting Proteins for HARBI1 Gene

Gene Ontology (GO) - Biological Process for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with HARBI1: view

No data available for Pathways by source and SIGNOR curated interactions for HARBI1 Gene

Drugs & Compounds for HARBI1 Gene

No Compound Related Data Available

Transcripts for HARBI1 Gene

mRNA/cDNA for HARBI1 Gene

Unigene Clusters for HARBI1 Gene

Harbinger transposase derived 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HARBI1 Gene

No ASD Table

Relevant External Links for HARBI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HARBI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HARBI1 Gene

mRNA differential expression in normal tissues according to GTEx for HARBI1 Gene

This gene is overexpressed in Testis (x5.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HARBI1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HARBI1 Gene:


SOURCE GeneReport for Unigene cluster for HARBI1 Gene:


mRNA Expression by UniProt/SwissProt for HARBI1 Gene:

Tissue specificity: Detected in brain, eye, nerve tissue, kidney and lung.

Evidence on tissue expression from TISSUES for HARBI1 Gene

  • Pancreas(4.6)
  • Intestine(3)
  • Nervous system(2.9)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with HARBI1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HARBI1 Gene

Orthologs for HARBI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HARBI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HARBI1 33 34
  • 99.52 (n)
(Canis familiaris)
Mammalia HARBI1 33 34
  • 93.03 (n)
(Bos Taurus)
Mammalia HARBI1 33 34
  • 91.31 (n)
(Monodelphis domestica)
Mammalia HARBI1 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Harbi1 33
  • 88.25 (n)
(Mus musculus)
Mammalia Harbi1 33 16 34
  • 87.39 (n)
(Ornithorhynchus anatinus)
Mammalia HARBI1 34
  • 84 (a)
(Gallus gallus)
Aves HARBI1 33 34
  • 76.72 (n)
(Anolis carolinensis)
Reptilia HARBI1 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493758 33
  • 68.59 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26314 33
(Danio rerio)
Actinopterygii harbi1 33 34
  • 63.79 (n)
Dr.15651 33
fruit fly
(Drosophila melanogaster)
Insecta CG43088 34
  • 16 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G55350 33
  • 41.51 (n)
(Oryza sativa)
Liliopsida Os01g0838900 33
  • 43.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
Species where no ortholog for HARBI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HARBI1 Gene

Gene Tree for HARBI1 (if available)
Gene Tree for HARBI1 (if available)

Paralogs for HARBI1 Gene

No data available for Paralogs for HARBI1 Gene

Variants for HARBI1 Gene

Sequence variations from dbSNP and Humsavar for HARBI1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000020603 -- 46,614,527(+) GGCCA(A/G)GAGCT intron-variant
rs1000138243 -- 46,608,096(+) GAGTT(C/T)GAGAC intron-variant
rs1000194244 -- 46,617,167(+) CCACC(C/T)AGCCG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000341024 -- 46,607,443(+) AAGAG(-/CAT)AATAA intron-variant
rs1000394734 -- 46,607,171(+) GGTAG(-/AAAA)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HARBI1 Gene

Variant ID Type Subtype PubMed ID
esv993220 OTHER inversion 20482838
esv3387485 CNV insertion 20981092

Variation tolerance for HARBI1 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HARBI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HARBI1 Gene

Disorders for HARBI1 Gene

Relevant External Links for HARBI1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HARBI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HARBI1 Gene

Publications for HARBI1 Gene

  1. Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PMID: 18339812) Sinzelle L … Ivics Z (Proceedings of the National Academy of Sciences of the United States of America 2008) 2 3 4 60
  2. Harbinger transposons and an ancient HARBI1 gene derived from a transposase. (PMID: 15169610) Kapitonov VV … Jurka J (DNA and cell biology 2004) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for HARBI1 Gene

Sources for HARBI1 Gene

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