HARBI1 Gene
protein-coding GIFtS: 37
GCID: GC11M048067
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harbinger transposase derived 1(Previous name: chromosome 11 open reading frame 77 )
(Previous symbol: C11orf77)
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Aliases
for HARBI1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Harbinger Transposase Derived 11 2 | | Chromosome 11 Open Reading Frame 771 | | C11orf771 2 3 | | Putative Nuclease HARBI12 | | Harbinger Transposase-Derived Nuclease2 3 | | EC 3.1.-.-3 | | FLJ326751 | | |
Export aliases for HARBI1 gene to outside databasesPrevious GC identifers: GC11M046583 GC11M046331 GC11M046672 |
Summaries
for HARBI1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HARB1_HUMAN, Q96MB7Function: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity
|
Genomic Views
for HARBI1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HARBI1 gene promoter:
NF-1 NF-1/L Egr-1 MIF-1 CUTL1 YY1 GATA-2 HFH-1 Pax-4a LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HARBI1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HARBI1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2HARBI1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M048067: view genomic region
(about GC identifiers)
Start:
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46,624,411 bp from pter |
End:
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46,639,459 bp from pter |
Size:
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15,049 bases |
Orientation:
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minus strand |
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Proteins
for HARBI1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HARB1_HUMAN, Q96MB7 (See
protein sequence)Recommended Name: Putative nuclease HARBI1 Size: 349 amino acids; 39146 Da
Cofactor: Divalent metal cations (Potential)
Subunit: Interacts with NAIF1
Subcellular location: Nucleus. Cytoplasm. Note=Interaction with NAIF1 promotes translocation to the nucleus
Secondary accessions: D3DQP9Explore the universe of human proteins at neXtProt for HARBI1: NX_Q96MB7
HARBI1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_776172.1
ENSEMBL proteins: ENSP00000317743 ENSP00000431697 ENSP00000436232
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
HARBI1 for ontologies About GeneDecksing
HARBI1 Antibody Products:
Assay Products for HARBI1: |
Protein
Domains /
Families
for HARBI1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HARBI1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96MB7ProtoNet protein and cluster: Q96MB7 UniProtKB/Swiss-Prot: HARB1_HUMAN, Q96MB7Similarity: Belongs to the HARBI1 family |
Function
for HARBI1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HARB1_HUMAN, Q96MB7Function: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activityEnzyme Number (IUBMB): EC 3.1.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HARBI1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HARBI1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HARBI1 (NM_173811) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HARBI1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HARBI1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HARBI1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004518 | nuclease activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
HARBI1 for ontologies About GeneDecksing
|
Pathways & Interactions
for HARBI1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HARBI1
|
Drugs & Compounds
for HARBI1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HARBI1
Search CenterWatch for drugs/clinical trials and news about HARBI1 / HARB1
|
Transcripts
for HARBI1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HARBI1 gene: NM_173811.3 Unigene Cluster for HARBI1: Harbinger transposase derived 1 Hs.714463 [show with all ESTs]Unigene Representative Sequence: AK0572373 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000326737(uc001ncy.3) ENST00000529192 ENST00000532281
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HARBI1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HARBI1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HARBI1 (NM_173811) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HARBI1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HARBI1 |
Additional cDNA sequence: AK057237.1 BC036925.1 13 DOTS entries: DT.91969874 DT.97864334 DT.120718165 DT.40131395 DT.100018696 DT.100845976 DT.120718234 DT.120718265 DT.100845983 DT.120718174 DT.120718252 DT.92449892 DT.97864335 20 AceView cDNA sequences: BM768489 BE465773 CD108866 BC036925 CA748949 BM725761 AA954503 BI825664 AW150877 AK057237 NM_173811 BG390807 BI837598 AI476263 BX114815 BI827167 BE897717 BU679045 CF596540 BE273825
GeneLoc Exon Structure
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Expression
for HARBI1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HARBI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HARBI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HARBI1
SOURCE GeneReport for Unigene cluster: Hs.714463
UniProtKB/Swiss-Prot: HARB1_HUMAN, Q96MB7Tissue specificity: Detected in brain, eye, nerve tissue, kidney and lung
SABiosciences Custom PCR Arrays for HARBI1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HARBI1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HARBI1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HARBI1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HARBI1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HARBI1 |
Orthologs
for HARBI1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HARBI1 gene from 8/16 species (see all 16) About this table
ENSEMBL Gene Tree for HARBI1 (if available)
TreeFam Gene Tree for HARBI1 (if available) |
Paralogs
for HARBI1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HARBI1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HARBI1 (46624411 - 46639459 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HARBI1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HARBI1 |
|
Disorders
/ Diseases
for HARBI1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 HARBI1 for disorders About MalaCards
HARBI1 for disorders About GeneDecksing
OMIM gene information: 615086
OMIM disorders: --
Export disorders for HARBI1 gene to outside databases
|
Publications
for HARBI1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HARBI1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HARBI1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PubMed id 18339812)1, 2, 3 Sinzelle L....Ivics Z. (2008)
- Harbinger transposons and an ancient HARBI1 gene derived from a transposase. (PubMed id 15169610)1, 2, 3 Kapitonov V.V. and Jurka J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Association of IFIH1 and other autoimmunity risk alle les with selective IgA deficiency. (PubMed id 20694011)1 Ferreira R.C....HammarstrAPm L. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for HARBI1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing HARBI1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HARBI1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HARBI1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HARBI1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HARBI1 gene:
Search GeneIP for patents involving HARBI1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HARBI1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HARBI1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HARBI1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HARBI1 | | | OriGene Protein Over-expression Lysate for HARBI1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HARBI1 | | OriGene 3'-UTR Clone for HARBI1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HARBI1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HARBI1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HARBI1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HARBI1 | | OriGene Custom Protein Services for HARBI1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HARBI1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HARBI1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HARBI1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HARBI1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HARBI1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HARBI1 |
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| | | | Search Tocris compounds for HARBI1 |
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 | | | HARBI1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HARBI1 |
|  |  |  | | | | Search ThermoFisher Antibodies for HARBI1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HARBI1 |
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