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Aliases for HARBI1 Gene

Aliases for HARBI1 Gene

  • Harbinger Transposase Derived 1 2 3
  • Harbinger Transposase-Derived Nuclease 3 4
  • C11orf77 3 4
  • Chromosome 11 Open Reading Frame 77 2
  • Putative Nuclease HARBI1 3
  • EC 3.1.-.- 4

External Ids for HARBI1 Gene

Previous Symbols for HARBI1 Gene

  • C11orf77

Summaries for HARBI1 Gene

GeneCards Summary for HARBI1 Gene

HARBI1 (Harbinger Transposase Derived 1) is a Protein Coding gene. GO annotations related to this gene include nuclease activity.

UniProtKB/Swiss-Prot for HARBI1 Gene

  • Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HARBI1 Gene

Genomics for HARBI1 Gene

Genomic Location for HARBI1 Gene

46,602,861 bp from pter
46,617,909 bp from pter
15,049 bases
Minus strand

Genomic View for HARBI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HARBI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HARBI1 Gene

Regulatory Elements for HARBI1 Gene

Proteins for HARBI1 Gene

  • Protein details for HARBI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative nuclease HARBI1
    Protein Accession:
    Secondary Accessions:
    • D3DQP9

    Protein attributes for HARBI1 Gene

    349 amino acids
    Molecular mass:
    39146 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Interacts with NAIF1.

neXtProt entry for HARBI1 Gene

Proteomics data for HARBI1 Gene at MOPED

Post-translational modifications for HARBI1 Gene

No Post-translational modifications

Other Protein References for HARBI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HARBI1 Gene

Domains for HARBI1 Gene

Protein Domains for HARBI1 Gene



  • Belongs to the HARBI1 family.:
    • Q96MB7
genes like me logo Genes that share domains with HARBI1: view

No data available for Gene Families for HARBI1 Gene

Function for HARBI1 Gene

Molecular function for HARBI1 Gene

UniProtKB/Swiss-Prot Function: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

Enzyme Numbers (IUBMB) for HARBI1 Gene

Gene Ontology (GO) - Molecular Function for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HARBI1: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HARBI1 Gene

Localization for HARBI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HARBI1 Gene

Nucleus. Cytoplasm. Note=Interaction with NAIF1 promotes translocation to the nucleus.

Subcellular locations from

Jensen Localization Image for HARBI1 Gene COMPARTMENTS Subcellular localization image for HARBI1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with HARBI1: view

Pathways for HARBI1 Gene

SuperPathways for HARBI1 Gene

No Data Available

Interacting Proteins for HARBI1 Gene

Gene Ontology (GO) - Biological Process for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with HARBI1: view

No data available for Pathways by source for HARBI1 Gene

Transcripts for HARBI1 Gene

mRNA/cDNA for HARBI1 Gene

Unigene Clusters for HARBI1 Gene

Harbinger transposase derived 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HARBI1 Gene

No ASD Table

Relevant External Links for HARBI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HARBI1 Gene

mRNA expression in normal human tissues for HARBI1 Gene

mRNA differential expression in normal tissues according to GTEx for HARBI1 Gene

This gene is overexpressed in Testis (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HARBI1 Gene

SOURCE GeneReport for Unigene cluster for HARBI1 Gene Hs.714463

mRNA Expression by UniProt/SwissProt for HARBI1 Gene

Tissue specificity: Detected in brain, eye, nerve tissue, kidney and lung.
genes like me logo Genes that share expressions with HARBI1: view

Orthologs for HARBI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HARBI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HARBI1 36
  • 99.52 (n)
  • 99.43 (a)
  • 99 (a)
(Bos Taurus)
Mammalia HARBI1 36
  • 91.31 (n)
  • 96.28 (a)
  • 96 (a)
(Canis familiaris)
Mammalia HARBI1 36
  • 93.03 (n)
  • 97.13 (a)
  • 97 (a)
(Mus musculus)
Mammalia Harbi1 36
  • 87.39 (n)
  • 89.97 (a)
Harbi1 16
Harbi1 37
  • 90 (a)
(Monodelphis domestica)
Mammalia HARBI1 37
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia HARBI1 37
  • 84 (a)
(Rattus norvegicus)
Mammalia Harbi1 36
  • 88.25 (n)
  • 93.41 (a)
(Gallus gallus)
Aves HARBI1 36
  • 76.72 (n)
  • 84.77 (a)
  • 84 (a)
(Anolis carolinensis)
Reptilia HARBI1 37
  • 84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26314 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493758 36
  • 68.59 (n)
  • 73.2 (a)
(Danio rerio)
Actinopterygii Dr.15651 36
harbi1 36
  • 63.79 (n)
  • 62.36 (a)
harbi1 37
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43088 37
  • 16 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G55350 36
  • 41.51 (n)
  • 27.59 (a)
(Oryza sativa)
Liliopsida Os01g0838900 36
  • 43.04 (n)
  • 31.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
Species with no ortholog for HARBI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HARBI1 Gene

Gene Tree for HARBI1 (if available)
Gene Tree for HARBI1 (if available)

Paralogs for HARBI1 Gene

No data available for Paralogs for HARBI1 Gene

Variants for HARBI1 Gene

Sequence variations from dbSNP and Humsavar for HARBI1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2069089 -- 46,605,064(+) AACCT(C/T)TTAGA intron-variant
rs6485685 -- 46,612,915(+) gatcc(A/G)cttgc intron-variant
rs7118544 -- 46,607,493(+) TAAGA(A/T)GAATA intron-variant
rs7124331 -- 46,605,417(+) aggct(A/G)gtctc intron-variant
rs7924401 -- 46,614,145(+) tatat(A/T)ggctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HARBI1 Gene

Variant ID Type Subtype PubMed ID
nsv897321 CNV Gain 21882294
esv993220 OTHER Inversion 20482838

Relevant External Links for HARBI1 Gene

HapMap Linkage Disequilibrium report

Disorders for HARBI1 Gene

No disorders were found for HARBI1 Gene.

No data available for UniProtKB/Swiss-Prot for HARBI1 Gene

Publications for HARBI1 Gene

  1. Harbinger transposons and an ancient HARBI1 gene derived from a transposase. (PMID: 15169610) Kapitonov V.V. … Jurka J. (DNA Cell Biol. 2004) 2 3 4
  2. Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PMID: 18339812) Sinzelle L. … Ivics Z. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for HARBI1 Gene

Sources for HARBI1 Gene

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