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Aliases for HARBI1 Gene

Aliases for HARBI1 Gene

  • Harbinger Transposase Derived 1 2 3 5
  • Harbinger Transposase-Derived Nuclease 3 4
  • C11orf77 3 4
  • Chromosome 11 Open Reading Frame 77 2
  • Putative Nuclease HARBI1 3
  • EC 3.1.-.- 4

External Ids for HARBI1 Gene

Previous HGNC Symbols for HARBI1 Gene

  • C11orf77

Previous GeneCards Identifiers for HARBI1 Gene

  • GC11M046583
  • GC11M046331
  • GC11M046672
  • GC11M048067
  • GC11M048792
  • GC11M049891
  • GC11M047079
  • GC11M047924
  • GC11M050780
  • GC11M051575
  • GC11M052237
  • GC11M052897
  • GC11M053565

Summaries for HARBI1 Gene

GeneCards Summary for HARBI1 Gene

HARBI1 (Harbinger Transposase Derived 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and nuclease activity.

UniProtKB/Swiss-Prot for HARBI1 Gene

  • Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

Additional gene information for HARBI1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HARBI1 Gene

Genomics for HARBI1 Gene

GeneHancer (GH) Regulatory Elements for HARBI1 Gene

Promoters and enhancers for HARBI1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I046615 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 429 4.6 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF213 ATG13 HARBI1 PIR50656 ENSG00000270060 ZNF408 DDB2 RPS10P19
GH11I046552 Enhancer 1.2 Ensembl ENCODE 11.6 +62.3 62283 5.5 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 SLC30A9 FOS ATG13 AMBRA1 HARBI1 CHRM4 MDK DGKZ C11orf49 ZNF408 MIR3160-1
GH11I046344 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 5.1 +268.0 268003 10.4 HDGF SMAD1 FOXA2 ARNT SIN3A ZNF2 YY1 E2F8 ZNF143 SP3 GC11P046351 DGKZ C11orf49 MDK CHRM4 CREB3L1 LINC02489 AMBRA1 PACSIN3 ATG13
GH11I046647 Enhancer 1 Ensembl ENCODE dbSUPER 11.7 -31.3 -31327 2.8 NFIA RXRA JUN RAD21 ATF2 NR2F2 JUND POLR2A ZBTB48 ZNF629 GC11M054627 ATG13 ARHGAP1 ZNF408 HARBI1 F2 AMBRA1 CHRM4 SNORD67 CKAP5
GH11I046559 Enhancer 0.9 Ensembl ENCODE 12.1 +56.9 56857 3.2 HDGF IRF2 PKNOX1 ETV1 ZBTB40 E4F1 IRF4 ZNF335 ZNF366 STAT2 ATG13 AMBRA1 HARBI1 CHRM4 MDK DGKZ MIR3160-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HARBI1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HARBI1 gene promoter:

Genomic Locations for HARBI1 Gene

Genomic Locations for HARBI1 Gene
15,049 bases
Minus strand

Genomic View for HARBI1 Gene

Genes around HARBI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HARBI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HARBI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HARBI1 Gene

Proteins for HARBI1 Gene

  • Protein details for HARBI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative nuclease HARBI1
    Protein Accession:
    Secondary Accessions:
    • D3DQP9

    Protein attributes for HARBI1 Gene

    349 amino acids
    Molecular mass:
    39146 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Interacts with NAIF1.

neXtProt entry for HARBI1 Gene

Post-translational modifications for HARBI1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HARBI1 Gene

Domains & Families for HARBI1 Gene

Gene Families for HARBI1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HARBI1 Gene


Suggested Antigen Peptide Sequences for HARBI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HARBI1 family.
  • Belongs to the HARBI1 family.
genes like me logo Genes that share domains with HARBI1: view

Function for HARBI1 Gene

Molecular function for HARBI1 Gene

UniProtKB/Swiss-Prot Function:
Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

Enzyme Numbers (IUBMB) for HARBI1 Gene

Phenotypes From GWAS Catalog for HARBI1 Gene

Gene Ontology (GO) - Molecular Function for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HARBI1: view

Phenotypes for HARBI1 Gene

genes like me logo Genes that share phenotypes with HARBI1: view

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HARBI1 Gene

Localization for HARBI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HARBI1 Gene

Nucleus. Cytoplasm. Note=Interaction with NAIF1 promotes translocation to the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HARBI1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with HARBI1: view

Pathways & Interactions for HARBI1 Gene

SuperPathways for HARBI1 Gene

No Data Available

Interacting Proteins for HARBI1 Gene

Gene Ontology (GO) - Biological Process for HARBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with HARBI1: view

No data available for Pathways by source and SIGNOR curated interactions for HARBI1 Gene

Drugs & Compounds for HARBI1 Gene

No Compound Related Data Available

Transcripts for HARBI1 Gene

mRNA/cDNA for HARBI1 Gene

Unigene Clusters for HARBI1 Gene

Harbinger transposase derived 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HARBI1 Gene

No ASD Table

Relevant External Links for HARBI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HARBI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HARBI1 Gene

mRNA differential expression in normal tissues according to GTEx for HARBI1 Gene

This gene is overexpressed in Testis (x5.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HARBI1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HARBI1 Gene:


SOURCE GeneReport for Unigene cluster for HARBI1 Gene:


mRNA Expression by UniProt/SwissProt for HARBI1 Gene:

Tissue specificity: Detected in brain, eye, nerve tissue, kidney and lung.

Evidence on tissue expression from TISSUES for HARBI1 Gene

  • Pancreas(4.6)
  • Intestine(3)
  • Nervous system(2.9)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with HARBI1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HARBI1 Gene

Orthologs for HARBI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HARBI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HARBI1 33 34
  • 99.52 (n)
(Canis familiaris)
Mammalia HARBI1 33 34
  • 93.03 (n)
(Bos Taurus)
Mammalia HARBI1 33 34
  • 91.31 (n)
(Monodelphis domestica)
Mammalia HARBI1 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Harbi1 33
  • 88.25 (n)
(Mus musculus)
Mammalia Harbi1 33 16 34
  • 87.39 (n)
(Ornithorhynchus anatinus)
Mammalia HARBI1 34
  • 84 (a)
(Gallus gallus)
Aves HARBI1 33 34
  • 76.72 (n)
(Anolis carolinensis)
Reptilia HARBI1 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493758 33
  • 68.59 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26314 33
(Danio rerio)
Actinopterygii harbi1 33 34
  • 63.79 (n)
Dr.15651 33
fruit fly
(Drosophila melanogaster)
Insecta CG43088 34
  • 16 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G55350 33
  • 41.51 (n)
(Oryza sativa)
Liliopsida Os01g0838900 33
  • 43.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
Species where no ortholog for HARBI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HARBI1 Gene

Gene Tree for HARBI1 (if available)
Gene Tree for HARBI1 (if available)

Paralogs for HARBI1 Gene

No data available for Paralogs for HARBI1 Gene

Variants for HARBI1 Gene

Sequence variations from dbSNP and Humsavar for HARBI1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000020603 -- 46,614,527(-) G/A intron_variant
rs1000138243 -- 46,608,096(-) T/C intron_variant
rs1000194244 -- 46,617,167(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000341024 -- 46,607,443(-) CAT/ intron_variant
rs1000394734 -- 46,607,171(-) AAAA/ intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HARBI1 Gene

Variant ID Type Subtype PubMed ID
esv3387485 CNV insertion 20981092
esv993220 OTHER inversion 20482838

Variation tolerance for HARBI1 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HARBI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HARBI1 Gene

Disorders for HARBI1 Gene

Additional Disease Information for HARBI1

No disorders were found for HARBI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HARBI1 Gene

Publications for HARBI1 Gene

  1. Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PMID: 18339812) Sinzelle L … Ivics Z (Proceedings of the National Academy of Sciences of the United States of America 2008) 2 3 4 58
  2. Harbinger transposons and an ancient HARBI1 gene derived from a transposase. (PMID: 15169610) Kapitonov VV … Jurka J (DNA and cell biology 2004) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for HARBI1 Gene

Sources for HARBI1 Gene

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