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Aliases for HAPLN4 Gene

Aliases for HAPLN4 Gene

  • Hyaluronan And Proteoglycan Link Protein 4 2 3
  • Brain Link Protein 2 2 3 4
  • BRAL2 3 4
  • KIAA1926 4

External Ids for HAPLN4 Gene

Previous GeneCards Identifiers for HAPLN4 Gene

  • GC19M019227
  • GC19M019229
  • GC19M019230
  • GC19M019366
  • GC19M018932

Summaries for HAPLN4 Gene

GeneCards Summary for HAPLN4 Gene

HAPLN4 (Hyaluronan And Proteoglycan Link Protein 4) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include hyaluronic acid binding. An important paralog of this gene is HAPLN1.

UniProtKB/Swiss-Prot for HAPLN4 Gene

  • Binds to hyaluronic acid and may be involved in formation of the extracellular matrix.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAPLN4 Gene

Genomics for HAPLN4 Gene

Regulatory Elements for HAPLN4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HAPLN4 Gene

19,255,641 bp from pter
19,262,796 bp from pter
7,156 bases
Minus strand

Genomic View for HAPLN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAPLN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAPLN4 Gene

Proteins for HAPLN4 Gene

  • Protein details for HAPLN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hyaluronan and proteoglycan link protein 4
    Protein Accession:
    Secondary Accessions:
    • A5PKW5
    • Q96PW2

    Protein attributes for HAPLN4 Gene

    402 amino acids
    Molecular mass:
    42801 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB67819.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HAPLN4 Gene

Proteomics data for HAPLN4 Gene at MOPED

Post-translational modifications for HAPLN4 Gene

  • Glycosylation at Asn132
  • Modification sites at PhosphoSitePlus

Other Protein References for HAPLN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HAPLN4 Gene

Domains for HAPLN4 Gene

Gene Families for HAPLN4 Gene

  • VSET :Immunoglobulin superfamily / V-set domain containing

Suggested Antigen Peptide Sequences for HAPLN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86UW8
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 2 Link domains.
  • Belongs to the HAPLN family.
genes like me logo Genes that share domains with HAPLN4: view

Function for HAPLN4 Gene

Molecular function for HAPLN4 Gene

UniProtKB/Swiss-Prot Function:
Binds to hyaluronic acid and may be involved in formation of the extracellular matrix.

Gene Ontology (GO) - Molecular Function for HAPLN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IBA --
GO:0005515 protein binding --
GO:0005540 hyaluronic acid binding IBA --
genes like me logo Genes that share ontologies with HAPLN4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HAPLN4 Gene

Localization for HAPLN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAPLN4 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for HAPLN4 Gene COMPARTMENTS Subcellular localization image for HAPLN4 gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HAPLN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IBA --
genes like me logo Genes that share ontologies with HAPLN4: view

Pathways for HAPLN4 Gene

genes like me logo Genes that share pathways with HAPLN4: view

Pathways by source for HAPLN4 Gene

Interacting Proteins for HAPLN4 Gene

Gene Ontology (GO) - Biological Process for HAPLN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IBA --
GO:0007155 cell adhesion IBA --
GO:0007417 central nervous system development IBA --
genes like me logo Genes that share ontologies with HAPLN4: view

Compounds for HAPLN4 Gene

(1) HMDB Compounds for HAPLN4 Gene

Compound Synonyms Cas Number PubMed IDs
Hyaluronic acid
  • hyaluronic acid
genes like me logo Genes that share compounds with HAPLN4: view

Transcripts for HAPLN4 Gene

mRNA/cDNA for HAPLN4 Gene

(43) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HAPLN4 Gene

Hyaluronan and proteoglycan link protein 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAPLN4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAPLN4 Gene

No ASD Table

Relevant External Links for HAPLN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HAPLN4 Gene

mRNA expression in normal human tissues for HAPLN4 Gene

mRNA differential expression in normal tissues according to GTEx for HAPLN4 Gene

This gene is overexpressed in Brain - Cortex (12.1), Brain - Frontal Cortex (BA9) (10.3), and Brain - Anterior cingulate cortex (BA24) (5.5).

Protein differential expression in normal tissues for HAPLN4 Gene

This gene is overexpressed in Frontal cortex (30.8), Adipocyte (23.7), Spinal cord (8.2), and Heart (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HAPLN4 Gene

SOURCE GeneReport for Unigene cluster for HAPLN4 Gene Hs.367829

mRNA Expression by UniProt/SwissProt for HAPLN4 Gene

Tissue specificity: Expressed predominantly in brain.
genes like me logo Genes that share expressions with HAPLN4: view

Expression partners for HAPLN4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HAPLN4 Gene

Orthologs for HAPLN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HAPLN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HAPLN4 35
  • 87.56 (n)
  • 96.27 (a)
  • 97 (a)
(Canis familiaris)
Mammalia HAPLN4 35
  • 87.81 (n)
  • 95.52 (a)
  • 95 (a)
(Mus musculus)
Mammalia Hapln4 35
  • 83.96 (n)
  • 91.48 (a)
Hapln4 16
Hapln4 36
  • 91 (a)
(Pan troglodytes)
Mammalia HAPLN4 35
  • 99.17 (n)
  • 99.75 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Hapln4 35
  • 83.63 (n)
  • 91.23 (a)
(Monodelphis domestica)
Mammalia HAPLN4 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia HAPLN4 36
  • 62 (a)
(Gallus gallus)
Aves HAPLN4 35
  • 70.77 (n)
  • 71.92 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia HAPLN4 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hapln4 35
  • 59.21 (n)
  • 66.47 (a)
(Danio rerio)
Actinopterygii hapln4 35
  • 63.81 (n)
  • 65.4 (a)
hapln4 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea clec-149 36
  • 10 (a)
Species with no ortholog for HAPLN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HAPLN4 Gene

Gene Tree for HAPLN4 (if available)
Gene Tree for HAPLN4 (if available)

Paralogs for HAPLN4 Gene

Paralogs for HAPLN4 Gene

Selected SIMAP similar genes for HAPLN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HAPLN4: view

Variants for HAPLN4 Gene

Sequence variations from dbSNP and Humsavar for HAPLN4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs988339 -- 19,255,598(+) TTATC(A/T)ACCAA downstream-variant-500B
rs2074295 -- 19,258,626(+) CCTGC(A/G)CTCCC synonymous-codon, reference
rs2074296 -- 19,262,880(+) GGTGT(A/G)TTAAA upstream-variant-2KB
rs2074297 -- 19,263,033(+) TTTAA(C/G)CATCT upstream-variant-2KB
rs2106864 -- 19,259,796(+) CCTAG(A/C)ATCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAPLN4 Gene

Variant ID Type Subtype PubMed ID
nsv911303 CNV Loss 21882294
nsv911304 CNV Loss 21882294
nsv911305 CNV Loss 21882294
nsv911306 CNV Loss 21882294

Relevant External Links for HAPLN4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAPLN4 Gene

Disorders for HAPLN4 Gene

Relevant External Links for HAPLN4

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for HAPLN4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HAPLN4 Gene

Publications for HAPLN4 Gene

  1. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. (PMID: 12663660) Spicer A.P. … Bowling R.A. Jr. (J. Biol. Chem. 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  3. Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets. (PMID: 14550776) Bekku Y. … Oohashi T. (Mol. Cell. Neurosci. 2003) 3 4
  4. Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas. (PMID: 19633295) Sim H. … Viapiano M.S. (J. Biol. Chem. 2009) 3
  5. Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area. (PMID: 20950796) KAohler A.K. … Andreassen O.A. (Biol. Psychiatry 2011) 3

Products for HAPLN4 Gene

Sources for HAPLN4 Gene

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