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HAPLN3 Gene

protein-coding   GIFtS: 49

GC15M087221
hyaluronan and proteoglycan link protein 3
(Previous names: extracellular link domain containing, 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EXLD1)
Services    

Aliases &
Descriptions
for HAPLN3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
EXLD1 2, 3
HsT19883 1, 2
Descriptions
extracellular link domain containing, 1 1, 2
hyaluronan and proteoglycan link protein 3 2
External Ids
HGNC: 214461
Entrez Gene: 1458642
UniProtKB: Q96S863
Ensembl: ENSG000001405117
Search outside databases for aliases for HAPLN3 gene

Previous GC identifers: GC15M087007 GC15M087150

Summaries
for HAPLN3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for HAPLN3:
This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein
encoded by this gene may function in hyaluronic acid binding and cell adhesion. [provided by
RefSeq]

UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86
Function: May function in hyaluronic acid binding

Genomic Location
for HAPLN3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the HAPLN3 gene  

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

HAPLN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M087221:     (about GC identifiers)

Start:
 87,221,523 bp from pter
End:
 87,239,774 bp from pter
Size:
 18,252 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000015.8  NT_010274.16  

Proteins
for HAPLN3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86 (See protein sequence)
Recommended Name: Hyaluronan and proteoglycan link protein 3 precursor  
Size: 360 amino acids; 40894 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

REFSEQ proteins: NP_839946.1  

ENSEMBL proteins: 
ENSP00000352606 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (HAPLN3)
Human Recombinant Proteins from Abnova (HAPLN3)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005578 proteinaceous extracellular matrix IEA--
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Antibodies for HAPLN3: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (HAPLN3), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (HAPLN3)
Novus Biologicals Antibodies for HAPLN3

Assays for HAPLN3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for HAPLN3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5/6 InterPro domains/families (see all 6 ):
 IPR007110 Ig-like
 IPR003599 Ig_sub
 IPR016186 C-type_lectin-like
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set


   GeneDecks  HAPLN3 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q96S86

ProtoNet protein and cluster: Q96S86

3 Blocks protein families:
IPB000538 Link domain
IPB003599 Immunoglobulin subtype
IPB013106 Immunoglobulin V-set


UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86
Similarity: Belongs to the HAPLN family
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
Similarity: Contains 2 Link domains

Gene Function
for HAPLN3

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (HAPLN3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (HAPLN3)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178232

              Applied Biosystems Silencer® siRNAs for HAPLN3

              Sigma-Aldrich siRNA for HAPLN3  
                     Sigma-Aldrich shRNA for HAPLN3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for HAPLN3
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178232
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178232
                                 untagged cDNA clones in CMV expression vector (see all 2): AY037161 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_178232

UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86
Function: May function in hyaluronic acid binding

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005488 binding IEA--
GO:0005540 hyaluronic acid binding IEA--
About this table

Pathways & Interactions
for HAPLN3

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007155 cell adhesion IEA--
About this table

Drugs & Compounds
for HAPLN3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HAPLN3

Transcripts
for HAPLN3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (HAPLN3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (HAPLN3)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178232

              Sigma-Aldrich siRNA for HAPLN3  
                     Sigma-Aldrich shRNA for HAPLN3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_178232  

REFSEQ mRNAs for HAPLN3 gene: 

NM_178232.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_178232  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178232
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178232
                                 untagged cDNA clones in CMV expression vector (see all 2): AY037161 

Additional cDNA sequence: 

AK292055.1 AK292103.1 AY037161.1 AY262759.1 AY358500.1 BC053689.1 BC062320.1 CR613805.1 

9 DOTS entries:

DT.40234210  DT.101983664  DT.91684203  DT.121053642  DT.97837286  DT.100672574  DT.100691263  DT.411080 
DT.99950853 

24/79 AceView cDNA sequences (see all 79 ):

BI771095 BQ638707 CR613805 CB216043 AL545809 NM_178232 BC062320 BC053689 
R72730 AA156097 AY262759 AI739142 AL571513 BX464704 BG831794 BQ574595 
BX424359 BU624811 R74064 AI191861 AI867234 BM922473 CB528371 BX350098 

highest scoring ESTs for HAPLN3:

AI739142 AI867234 AL545809 AY262759 AY358500 BC053689 BE207594 BE898299 BF568322 BG831794 

Unigene Cluster for HAPLN3:

Hyaluronan and proteoglycan link protein 3
Hs.447530  [show with all ESTs]
Unigene Representative Sequence: BC053689


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for HAPLN3

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1:                                                  -     -               
SP2:                    -     -                       -     -               
SP3:                          -                                             
SP4:                                                                        
SP5:                    -     -                                             

About this scheme

ECgene alternative splicing isoforms for HAPLN3

1 Ensembl transcript including schematic representation:
ENST00000359595  

Expression
for HAPLN3

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HAPLN3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for HAPLN3

1 / 2 / 3

3 probe-sets matching HAPLN3 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

44513_at2, 3 U95-B 2 1.00 0.97 1.00 1.00 AI760613 0.60 1.00 0.82 1

227262_at2, 3 U133-B 1 1.00 1.00 -- -- BE348293 0.40 1.00 0.76 1

227262_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GTGGGCACAG

SOURCE GeneReport for Unigene cluster: Hs.447530

UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86
Tissue specificity: Widely expressed with highest levels in spleen and placenta

Orthologs
for HAPLN3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for HAPLN3 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 HAPLN31   -- hyaluronan and proteoglycan link protein 3 85.75(n)
82.68(a)		 609165  XM_846375.1  XP_851468.1 
chimpanzee
(Pan troglodytes)		 HAPLN31   -- hyaluronan and proteoglycan link protein 3 98.7(n)
98.89(a)		 453630  XM_001165614.1  XP_001165614.1 
cow
(Bos taurus)		 HAPLN31   -- hyaluronan and proteoglycan link protein 3 85.85(n)
80.73(a)		 515224  XM_593205.3  XP_593205.3 
rat
(Rattus norvegicus)		 Hapln31   -- hyaluronan and proteoglycan link protein 3 81.15(n)
81.62(a)		 308773  NM_001008559.1  NP_001008559.1 
mouse
(Mus musculus)		 Hapln31, 5 75
 hyaluronan and proteoglycan link protein 31, 5 80.78(n)1
80.78(a)1		 676661  NM_178255.31  NP_839986.21 
 AK0161235  AK0178655  (see all 9)
About this table        Species with no ortholog for HAPLN3

ENSEMBL Gene Tree for HAPLN3

Paralogs
for HAPLN3

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for HAPLN3 gene
HAPLN42  HAPLN12  NCAN2  HAPLN22  

SNPs/Variants
for HAPLN3

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/146 NCBI SNPs in HAPLN3 are shown (see all 146 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 81)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 15 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs80324631,2
A,C,F,H87241749(+) CCCTGT/CGGCCC 1 -- ng31 tfbs34Minor allele frequency- C:0.30EU EA WA 418
rs169424421,2
C,F,H87240536(+) GAAACA/GCTGGC 1 -- ng3116Minor allele frequency- G:0.30NA EA EU WA 1464
rs169424431,2
C,F,H87240828(+) TTTCCT/CCAGCA 1 -- ng3111Minor allele frequency- C:0.26NA EU EA WA 980
rs172018641,2
C,F,H87221978(+) AAAACC/TGCAAA 1 -- ut31 spl37Minor allele frequency- T:0.03NA EU EA WA 550
rs169424141,2
F,H87221688(+) CTCAGC/ATTTCG 1 -- ut31 ese37Minor allele frequency- A:0.19NA EU EA WA 542
--
rs116329351,2
C87240219(+) cagcaC/Ttttgg 1 -- ng310--------
rs22804631,2
A,C,F,H87222331(-) GATGGT/CAGCGT 1 G/G syn17Minor allele frequency- C:0.42EU EA WA NA 540
rs22804641,2
C,F,H87222253(-) TTCCCC/TGACCC 1 P/P syn1 ese38Minor allele frequency- T:0.06EA NA EU WA 1666
rs71827261,2
C,F,H87222409(+) TTGGCG/AATCGT 1 I/I syn1 ese37Minor allele frequency- A:0.17EU EA WA NA 554
rs37433951,2
C,F,H87231510(-) GTCCCG/ATTGCT 1 P/P syn1 ese35Minor allele frequency- A:0.21EA EU WA 1902
About this table

HapMap Linkage Disequilibrium images for HAPLN3 (up to first 250kb)

Disorders & Mutations
for HAPLN3

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for HAPLN3

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for HAPLN3

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for HAPLN3 gene:

Search for HAPLN3

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing HAPLN3

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 145864 HGNC: 21446 AceView: HAPLN3 Ensembl:ENSG00000140511 euGenes: HUgn145864
ECgene: HAPLN3 H-InvDB: HAPLN3

Other Databases showing HAPLN3

(According to HUGE)
About This Section

   --

Specialized Databases showing HAPLN3

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for HAPLN3

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for HAPLN3

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for HAPLN3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for HAPLN3-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for HAPLN3 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for HAPLN3 Browse small molecules at Sigma-Aldrich
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 Search Tocris compounds for HAPLN3




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 Antibodies for HAPLN3

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