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Aliases for HAPLN3 Gene

Aliases for HAPLN3 Gene

  • Hyaluronan And Proteoglycan Link Protein 3 2 3 5
  • Extracellular Link Domain Containing, 1 2 3
  • EXLD1 3 4
  • HsT19883 3

External Ids for HAPLN3 Gene

Previous HGNC Symbols for HAPLN3 Gene

  • EXLD1

Previous GeneCards Identifiers for HAPLN3 Gene

  • GC15M087007
  • GC15M087150
  • GC15M087221
  • GC15M089420
  • GC15M065532

Summaries for HAPLN3 Gene

Entrez Gene Summary for HAPLN3 Gene

  • This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this gene may function in hyaluronic acid binding and cell adhesion. [provided by RefSeq, Jul 2008]

GeneCards Summary for HAPLN3 Gene

HAPLN3 (Hyaluronan And Proteoglycan Link Protein 3) is a Protein Coding gene. Among its related pathways are Phospholipase-C Pathway and ERK Signaling. GO annotations related to this gene include extracellular matrix structural constituent and hyaluronic acid binding. An important paralog of this gene is HAPLN1.

UniProtKB/Swiss-Prot for HAPLN3 Gene

  • May function in hyaluronic acid binding.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAPLN3 Gene

Genomics for HAPLN3 Gene

Regulatory Elements for HAPLN3 Gene

Enhancers for HAPLN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F089016 1.3 Ensembl ENCODE 11.9 -122.0 -122012 2.6 ZFP64 SIN3A ZNF48 ZNF2 ELK1 GATA2 ZNF143 KLF7 FOS ZNF263 LOC100631255 POLG HAPLN3 RLBP1 AEN ENSG00000173867 MFGE8 GC15P089023 LOC100129942
GH15F088984 0.9 Ensembl ENCODE 11.5 -94.8 -94780 10.8 ATF1 PKNOX1 ARNT YY1 GLIS2 GATA2 FOS YY2 NCOA1 CREB3 MFGE8 HAPLN3 RLBP1 LOC100129942 GC15P089023
GH15F089001 0.7 Ensembl ENCODE 11.4 -107.6 -107600 3.3 PKNOX1 ELK1 FOS ZNF263 REST MEF2D MAFF SMARCA4 MYNN CTCF MFGE8 HAPLN3 RLBP1 AEN LOC100129942 GC15P089023
GH15F089040 0.7 Ensembl 11.4 -145.6 -145596 0.8 ZNF133 INSM2 GLI4 ZNF664 POLR2A PRDM10 ZNF600 FOS ZBTB20 THAP11 ABHD2 HAPLN3 RLBP1 FANCI LOC102724566 GC15M089074
GH15F089051 1.4 FANTOM5 Ensembl ENCODE 11 -156.9 -156865 2.2 CEBPB FOS RNU7-195P HAPLN3 RLBP1 FANCI LOC102724566 ENSG00000261407 GC15M089074
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HAPLN3 on UCSC Golden Path with GeneCards custom track

Promoters for HAPLN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000128257 526 1401 SIN3A ZNF2 RAD21 GLIS2 SCRT2 ZNF143 ZNF263 ZNF654 ZNF280D SP3

Genomic Location for HAPLN3 Gene

88,877,288 bp from pter
88,895,626 bp from pter
18,339 bases
Minus strand

Genomic View for HAPLN3 Gene

Genes around HAPLN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAPLN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAPLN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAPLN3 Gene

Proteins for HAPLN3 Gene

  • Protein details for HAPLN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hyaluronan and proteoglycan link protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K7P0

    Protein attributes for HAPLN3 Gene

    360 amino acids
    Molecular mass:
    40894 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HAPLN3 Gene

Post-translational modifications for HAPLN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HAPLN3 Gene

Domains & Families for HAPLN3 Gene

Gene Families for HAPLN3 Gene

Suggested Antigen Peptide Sequences for HAPLN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the HAPLN family.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 2 Link domains.
  • Belongs to the HAPLN family.
genes like me logo Genes that share domains with HAPLN3: view

Function for HAPLN3 Gene

Molecular function for HAPLN3 Gene

UniProtKB/Swiss-Prot Function:
May function in hyaluronic acid binding.

Gene Ontology (GO) - Molecular Function for HAPLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IBA --
GO:0005540 hyaluronic acid binding IEA,IBA --
genes like me logo Genes that share ontologies with HAPLN3: view

Phenotypes for HAPLN3 Gene

GenomeRNAi human phenotypes for HAPLN3:
genes like me logo Genes that share phenotypes with HAPLN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HAPLN3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAPLN3 Gene

Localization for HAPLN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAPLN3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for HAPLN3 Gene COMPARTMENTS Subcellular localization image for HAPLN3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HAPLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA,IBA --
GO:0005615 extracellular space IDA 16502470
genes like me logo Genes that share ontologies with HAPLN3: view

Pathways & Interactions for HAPLN3 Gene

genes like me logo Genes that share pathways with HAPLN3: view

Pathways by source for HAPLN3 Gene

Interacting Proteins for HAPLN3 Gene

Gene Ontology (GO) - Biological Process for HAPLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IBA --
GO:0007155 cell adhesion IEA,IBA --
GO:0007417 central nervous system development IBA --
genes like me logo Genes that share ontologies with HAPLN3: view

No data available for SIGNOR curated interactions for HAPLN3 Gene

Drugs & Compounds for HAPLN3 Gene

(1) Drugs for HAPLN3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target, binder 439
genes like me logo Genes that share compounds with HAPLN3: view

Transcripts for HAPLN3 Gene

Unigene Clusters for HAPLN3 Gene

Hyaluronan and proteoglycan link protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAPLN3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - - - -
SP3: -
SP5: - -

Relevant External Links for HAPLN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HAPLN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HAPLN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAPLN3 Gene

This gene is overexpressed in Artery - Aorta (x7.1) and Artery - Coronary (x4.3).

Protein differential expression in normal tissues from HIPED for HAPLN3 Gene

This gene is overexpressed in Milk (26.9), Bone marrow mesenchymal stem cell (23.8), and Synovial fluid (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HAPLN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of HAPLN3 Gene:


SOURCE GeneReport for Unigene cluster for HAPLN3 Gene:


mRNA Expression by UniProt/SwissProt for HAPLN3 Gene:

Tissue specificity: Widely expressed with highest levels in spleen and placenta.
genes like me logo Genes that share expression patterns with HAPLN3: view

Primer Products

No data available for Protein tissue co-expression partners for HAPLN3 Gene

Orthologs for HAPLN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAPLN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HAPLN3 34 35
  • 98.7 (n)
(Bos Taurus)
Mammalia HAPLN3 34 35
  • 86.45 (n)
(Canis familiaris)
Mammalia HAPLN3 34 35
  • 85.75 (n)
(Rattus norvegicus)
Mammalia Hapln3 34
  • 82.31 (n)
(Mus musculus)
Mammalia Hapln3 34 16 35
  • 81.92 (n)
(Monodelphis domestica)
Mammalia HAPLN3 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia HAPLN3 35
  • 65 (a)
(Gallus gallus)
Aves HAPLN3 34 35
  • 69.53 (n)
(Anolis carolinensis)
Reptilia HAPLN3 35
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia usp12 34
  • 67.25 (n)
Str.16035 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53495 34
(Danio rerio)
Actinopterygii hapln3 34 35
  • 60.1 (n)
Species where no ortholog for HAPLN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAPLN3 Gene

Gene Tree for HAPLN3 (if available)
Gene Tree for HAPLN3 (if available)

Paralogs for HAPLN3 Gene

Paralogs for HAPLN3 Gene

(8) SIMAP similar genes for HAPLN3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HAPLN3: view

Variants for HAPLN3 Gene

Sequence variations from dbSNP and Humsavar for HAPLN3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10706089 -- 88,893,929(+) ATCTC(-/A)AAAAA intron-variant
rs111232466 -- 88,892,291(+) GTCTC(C/T)ACTAA intron-variant
rs111326005 -- 88,884,717(+) GATGT(C/T)GAGAT intron-variant
rs111444379 -- 88,891,402(+) AATGA(A/G)TCTCC intron-variant
rs111446206 -- 88,890,398(+) ACAGA(C/G)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAPLN3 Gene

Variant ID Type Subtype PubMed ID
esv3637178 CNV loss 21293372
nsv1653 CNV deletion 18451855

Variation tolerance for HAPLN3 Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.36; 95.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAPLN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAPLN3 Gene

Disorders for HAPLN3 Gene

Relevant External Links for HAPLN3

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HAPLN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAPLN3 Gene

Publications for HAPLN3 Gene

  1. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. (PMID: 12663660) Spicer A.P. … Bowling R.A. Jr. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area. (PMID: 20950796) KAohler A.K. … Andreassen O.A. (Biol. Psychiatry 2011) 3 64

Products for HAPLN3 Gene

Sources for HAPLN3 Gene

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