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Aliases for HAPLN3 Gene

Aliases for HAPLN3 Gene

  • Hyaluronan And Proteoglycan Link Protein 3 2 3 5
  • Extracellular Link Domain Containing, 1 2 3
  • EXLD1 3 4
  • HsT19883 3

External Ids for HAPLN3 Gene

Previous HGNC Symbols for HAPLN3 Gene

  • EXLD1

Previous GeneCards Identifiers for HAPLN3 Gene

  • GC15M087007
  • GC15M087150
  • GC15M087221
  • GC15M089420
  • GC15M065532

Summaries for HAPLN3 Gene

Entrez Gene Summary for HAPLN3 Gene

  • This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this gene may function in hyaluronic acid binding and cell adhesion. [provided by RefSeq, Jul 2008]

GeneCards Summary for HAPLN3 Gene

HAPLN3 (Hyaluronan And Proteoglycan Link Protein 3) is a Protein Coding gene. Among its related pathways are ERK Signaling and Integrin Pathway. GO annotations related to this gene include extracellular matrix structural constituent and hyaluronic acid binding. An important paralog of this gene is HAPLN2.

UniProtKB/Swiss-Prot for HAPLN3 Gene

  • May function in hyaluronic acid binding.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAPLN3 Gene

Genomics for HAPLN3 Gene

Regulatory Elements for HAPLN3 Gene

Promoters for HAPLN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HAPLN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HAPLN3 Gene

Chromosome:
15
Start:
88,877,288 bp from pter
End:
88,895,626 bp from pter
Size:
18,339 bases
Orientation:
Minus strand

Genomic View for HAPLN3 Gene

Genes around HAPLN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAPLN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAPLN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAPLN3 Gene

Proteins for HAPLN3 Gene

  • Protein details for HAPLN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S86-HPLN3_HUMAN
    Recommended name:
    Hyaluronan and proteoglycan link protein 3
    Protein Accession:
    Q96S86
    Secondary Accessions:
    • A8K7P0

    Protein attributes for HAPLN3 Gene

    Size:
    360 amino acids
    Molecular mass:
    40894 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HAPLN3 Gene

Proteomics data for HAPLN3 Gene at MOPED

Post-translational modifications for HAPLN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HAPLN3 Gene

Antibody Products

No data available for DME Specific Peptides for HAPLN3 Gene

Domains & Families for HAPLN3 Gene

Gene Families for HAPLN3 Gene

Suggested Antigen Peptide Sequences for HAPLN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S86

UniProtKB/Swiss-Prot:

HPLN3_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the HAPLN family.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 2 Link domains.
Family:
  • Belongs to the HAPLN family.
genes like me logo Genes that share domains with HAPLN3: view

Function for HAPLN3 Gene

Molecular function for HAPLN3 Gene

UniProtKB/Swiss-Prot Function:
May function in hyaluronic acid binding.

Gene Ontology (GO) - Molecular Function for HAPLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IBA --
genes like me logo Genes that share ontologies with HAPLN3: view

Phenotypes for HAPLN3 Gene

GenomeRNAi human phenotypes for HAPLN3:
genes like me logo Genes that share phenotypes with HAPLN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HAPLN3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAPLN3 Gene

Localization for HAPLN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAPLN3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAPLN3 Gene COMPARTMENTS Subcellular localization image for HAPLN3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for HAPLN3 Gene

Pathways & Interactions for HAPLN3 Gene

genes like me logo Genes that share pathways with HAPLN3: view

Interacting Proteins for HAPLN3 Gene

Gene Ontology (GO) - Biological Process for HAPLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,IBA --
genes like me logo Genes that share ontologies with HAPLN3: view

No data available for SIGNOR curated interactions for HAPLN3 Gene

Drugs & Compounds for HAPLN3 Gene

(1) Drugs for HAPLN3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronan Approved Pharma Target, binder 362
genes like me logo Genes that share compounds with HAPLN3: view

Transcripts for HAPLN3 Gene

Unigene Clusters for HAPLN3 Gene

Hyaluronan and proteoglycan link protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAPLN3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - - - -
SP3: -
SP4:
SP5: - -

Relevant External Links for HAPLN3 Gene

GeneLoc Exon Structure for
HAPLN3
ECgene alternative splicing isoforms for
HAPLN3

Expression for HAPLN3 Gene

mRNA expression in normal human tissues for HAPLN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAPLN3 Gene

This gene is overexpressed in Artery - Aorta (x7.1) and Artery - Coronary (x4.3).

Protein differential expression in normal tissues from HIPED for HAPLN3 Gene

This gene is overexpressed in Milk (26.9), Bone marrow mesenchymal stem cell (23.8), and Synovial fluid (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HAPLN3 Gene



SOURCE GeneReport for Unigene cluster for HAPLN3 Gene Hs.447530

mRNA Expression by UniProt/SwissProt for HAPLN3 Gene

Q96S86-HPLN3_HUMAN
Tissue specificity: Widely expressed with highest levels in spleen and placenta.
genes like me logo Genes that share expression patterns with HAPLN3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for HAPLN3 Gene

Orthologs for HAPLN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAPLN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HAPLN3 35
  • 86.45 (n)
  • 82.16 (a)
HAPLN3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAPLN3 35
  • 85.75 (n)
  • 82.68 (a)
HAPLN3 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hapln3 35
  • 81.92 (n)
  • 82.51 (a)
Hapln3 16
Hapln3 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HAPLN3 35
  • 98.7 (n)
  • 98.89 (a)
HAPLN3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hapln3 35
  • 82.31 (n)
  • 83.09 (a)
oppossum
(Monodelphis domestica)
Mammalia HAPLN3 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAPLN3 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves HAPLN3 35
  • 69.53 (n)
  • 61.54 (a)
HAPLN3 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HAPLN3 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16035 35
usp12 35
  • 67.25 (n)
  • 68.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53495 35
zebrafish
(Danio rerio)
Actinopterygii hapln3 35
  • 60.1 (n)
  • 59.13 (a)
hapln3 36
  • 57 (a)
OneToOne
Species with no ortholog for HAPLN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAPLN3 Gene

ENSEMBL:
Gene Tree for HAPLN3 (if available)
TreeFam:
Gene Tree for HAPLN3 (if available)

Paralogs for HAPLN3 Gene

Paralogs for HAPLN3 Gene

(8) SIMAP similar genes for HAPLN3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HAPLN3: view

Variants for HAPLN3 Gene

Sequence variations from dbSNP and Humsavar for HAPLN3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs939589 -- 88,882,819(-) ACTTT(A/G)TTGCC intron-variant
rs939590 -- 88,882,548(-) GTGAG(C/T)GTAGT intron-variant
rs875024 -- 88,880,518(-) CGTCC(C/T)AGCTA intron-variant, nc-transcript-variant
rs884727 -- 88,892,854(-) CCTCA(A/G)TGGTA intron-variant
rs938605 -- 88,881,350(+) TTAGC(A/G)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAPLN3 Gene

Variant ID Type Subtype PubMed ID
nsv904478 CNV Loss 21882294
nsv1653 CNV Loss 18451855

Variation tolerance for HAPLN3 Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.36; 95.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAPLN3 Gene

HapMap Linkage Disequilibrium report
HAPLN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAPLN3 Gene

Disorders for HAPLN3 Gene

Relevant External Links for HAPLN3

Human Genome Epidemiology (HuGE) Navigator
HAPLN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAPLN3

No disorders were found for HAPLN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAPLN3 Gene

Publications for HAPLN3 Gene

  1. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. (PMID: 12663660) Spicer A.P. … Bowling R.A. Jr. (J. Biol. Chem. 2003) 2 3 4 23 25 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area. (PMID: 20950796) KAohler A.K. … Andreassen O.A. (Biol. Psychiatry 2011) 3
  4. Significant elevation of CLDN16 and HAPLN3 gene expression in human breast cancer. (PMID: 20664984) Kuo S.J. … Chen D.R. (Oncol. Rep. 2010) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for HAPLN3 Gene

Sources for HAPLN3 Gene

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