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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HAPLN3 Gene

protein-coding GIFtS: 48
GCID: GC15M089420

hyaluronan and proteoglycan link protein 3

(Previous names: extracellular link domain containing, 1 )
(Previous symbol: EXLD1)

Explore 2 diseases affiliated with
HAPLN3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hyaluronan And Proteoglycan Link Protein 3¹ ²
EXLD1¹ ² ³
HsT19883¹ ²
Extracellular Link Domain Containing, 1¹ ²

External Ids:	HGNC: 21446¹	Entrez Gene: 145864²	Ensembl: ENSG00000140511⁷	UniProtKB: Q96S86³

Export aliases for HAPLN3 gene to outside databases

Previous GC identifers: GC15M087007 GC15M087150 GC15M087221 GC15M065532

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HAPLN3:

This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this gene

may function in hyaluronic acid binding and cell adhesion. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86

Function: May function in hyaluronic acid binding

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HAPLN3 gene promoter:
SRF AML1a SRF (504 AA) Pax-2 Pax-2a MIF-1 E47 Nkx6-1 SEF-1 (1) Hand1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HAPLN3 promoter sequence

Search SABiosciences Chromatin IP Primers for HAPLN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAPLN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q26.1

HAPLN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAPLN3 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M089420: view genomic region (about GC identifiers)

Start:	89,420,519 bp from pter	End:	89,438,857 bp from pter
Size:	18,339 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86 (See protein sequence)

Recommended Name: Hyaluronan and proteoglycan link protein 3 precursor

Size: 360 amino acids; 40894 Da

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Secondary accessions: A8K7P0

Explore the universe of human proteins at neXtProt for HAPLN3: NX_Q96S86

HAPLN3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_839946.1

ENSEMBL proteins:

ENSP00000352606 ENSP00000456458 ENSP00000457180 ENSP00000456985

Human Recombinant Protein Products:

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	Novus Biologicals HAPLN3 Protein Novus Biologicals HAPLN3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HAPLN3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--

HAPLN3 for ontologies About GeneDecksing

HAPLN3 Antibody Products:

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	Uscn Antibodies for HAPLN3
	ThermoFisher Antibodies for HAPLN3

Assay Products for HAPLN3:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HAPLN3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HAPLN3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HAPLN3 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR000538 Link

IPR007110 Ig-like_dom

IPR016187 C-type_lectin_fold

Graphical View of Domain Structure for InterPro Entry Q96S86

ProtoNet protein and cluster: Q96S86

3 Blocks protein families:

IPB000538 Link domain

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86

Similarity: Belongs to the HAPLN family

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

Similarity: Contains 2 Link domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86

Function: May function in hyaluronic acid binding

miRNA Products:		OriGene 3'-UTR Clone: HAPLN3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAPLN3
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate HAPLN3:
		hsa-miR-3163 hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-29b

		SwitchGear 3'UTR luciferase reporter plasmid: HAPLN3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAPLN3 (see all 7) OriGene shRNA RFP: HAPLN3 Browse OriGene siRNA
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HAPLN3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAPLN3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAPLN3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HAPLN3 (NM_178232)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAPLN3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAPLN3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HAPLN3
		Search LifeMap BioReagents cell lines for HAPLN3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAPLN3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005540	hyaluronic acid binding	IEA	--

HAPLN3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Hapln3^tm1Lex for HAPLN3
     1 MGI phenotypic allele

for Hapln3 (no phenotypes)

HAPLN3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

PTEN Pathway

PTEN Pathway

1.00

Phospholipase-C Pathway

0.56

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HAPLN3 (see all 13)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HAPLN3

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--

HAPLN3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HAPLN3

1 HMDB Compound for HAPLN3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Hyaluronic acid	hyaluronic acid	9004-61-9	--

Search CenterWatch for drugs/clinical trials and news about HAPLN3 / HPLN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HAPLN3 gene:

NM_178232.2

Unigene Cluster for HAPLN3:

Hyaluronan and proteoglycan link protein 3

Hs.447530 [show with all ESTs]

Unigene Representative Sequence: BC053689

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000359595(uc002bnc.3 uc002bnd.3) ENST00000558770(uc002bne.3)

ENST00000562889 ENST00000562281 ENST00000563808

miRNA Products:		OriGene 3'-UTR Clone: HAPLN3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAPLN3
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate HAPLN3:
		hsa-miR-3163 hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-29b

		SwitchGear 3'UTR luciferase reporter plasmid: HAPLN3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAPLN3 (see all 7) OriGene shRNA RFP: HAPLN3 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAPLN3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAPLN3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAPLN3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HAPLN3 (NM_178232)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAPLN3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAPLN3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAPLN3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HAPLN3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAPLN3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAPLN3

Additional cDNA sequence:

AK292055.1 AK292103.1 AY037161.1 AY262759.1 AY358500.1 BC053689.1 BC062320.1

9 DOTS entries:

DT.40234210 DT.101983664 DT.91684203 DT.121053642 DT.97837286 DT.100672574 DT.100691263 DT.411080

DT.99950853

24/79 AceView cDNA sequences (see all 79):

BI771095 CB216043 BC053689 R72730 AA156097 AL545809 AL571513 AY262759

NM_178232 BX464704 BC062320 AI739142 CR613805 BQ638707 BQ014264 AY037161

BE348293 BE898299 R74163 AL538776 BI194318 BX424359 BI823311 BQ183588

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for HAPLN3 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7
SP1:																	-		-
SP2:							-		-								-		-
SP3:									-
SP4:
SP5:							-		-

ECgene alternative splicing isoforms for HAPLN3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HAPLN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGGCACAG

About this image

HAPLN3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HAPLN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HAPLN3

SOURCE GeneReport for Unigene cluster: Hs.447530

UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86

Tissue specificity: Widely expressed with highest levels in spleen and placenta

SABiosciences Custom PCR Arrays for HAPLN3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAPLN3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HAPLN3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAPLN3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAPLN3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAPLN3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HAPLN3 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HAPLN3¹	hyaluronan and proteoglycan link protein 3	68.84(n) 60.91(a)		415495 XM_413868.3 XP_413868.3
lizard (Anolis carolinensis)	Reptilia	HAPLN3⁶	--	53(a)	1 ↔ 1	AAWZ02037182(9129-12919)
African clawed frog (Xenopus laevis)	Amphibia	MGC53495²	similar to cartilage link protein 1	73.32(n)		BC046259.1
zebrafish (Danio rerio)	Actinopterygii	hapln3¹	hyaluronan and proteoglycan link protein 3	60.26(n) 59.32(a)		406374 NM_213101.1 NP_998266.1

ENSEMBL Gene Tree for HAPLN3 (if available)
TreeFam Gene Tree for HAPLN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HAPLN3 gene

HAPLN1² HAPLN4² ACAN² BCAN² NCAN² VCAN² HAPLN2²

8 SIMAP similar genes for HAPLN3 using alignment to 4 protein entries: HPLN3_HUMAN (see all proteins):

HAPLN1 HAPLN2 HAPLN4 BCAN VCAN ACAN

CSPG3 variant protein NCAN

HAPLN3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188198102^1,2		--	89420050(+)	`ACTGAC/GCTAAG`	1	--	ds500¹		0	--	--	--	--
rs114687966^1,2	F,	--	89420097(+)	`GAGGCG/ATTCCT`	1	--	ds500¹		1		WA	118
rs192959764^1,2		--	89420098(+)	`AGGCGA/TTCCTG`	1	--	ds500¹		0	--	--	--	--
rs117215396^1,2		--	89420104(+)	`TCCTGC/TGCAAG`	1	--	ds500¹		1		EA	120
rs182420327^1,2		--	89420162(+)	`GGTGAA/GGCACA`	1	--	ds500¹		0	--	--	--	--
rs79853992^1,2		--	89420301(+)	`GGATGG/TTGAAG`	1	--	ds500¹		3		CSA WA EA	240
rs144298513^1,2		--	89420389(+)	`CCGCAA/GAGTTC`	1	--	ds500¹		0	--	--	--	--
rs77820871^1,2	F,	--	89420511(+)	`CACAGA/GAAAGG`	1	--	ds500¹		1		WA	118
rs186917318^1,2		--	89420638(+)	`GGAACC/TGAGAG`	1	--	ut3¹		0	--	--	--	--
rs16942414^1,2	C,F,H,	--	89420684(+)	`CTCAGC/ATTTCG`	1	--	ut3¹ ese³		19		NA NS EA WA CSA	1720

HapMap Linkage Disequilibrium report for HAPLN3 (89420519 - 89438857 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for HAPLN3
2 CNVs: 87831 77062
2 Indels: 87833 87832

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HAPLN3

DNA2.0 Custom Variant and Variant Library Synthesis for HAPLN3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HAPLN3 for disorders About GeneDecksing

2 diseases for HAPLN3: About MalaCards

breast cancer schizophrenia

Human Genome Epidemiology (HuGE) Navigator: HAPLN3 (1 document)

Export disorders for HAPLN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HAPLN3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HAPLN3)

Utopia: connect your pdf to the dynamic
world of online information

A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. (PubMed id 12663660)^{1, 2, 3, 9} Spicer A.P.... Bowling R.A. Jr. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associa ted with disease risk and cortical surface area. (PubMed id 20950796)¹ KAohler A.K....Andreassen O.A. (2011)
Significant elevation of CLDN16 and HAPLN3 gene expre ssion in human breast cancer. (PubMed id 20664984)¹ Kuo S.J....Chen D.R. (2010)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 145864	HGNC: 21446	AceView: HAPLN3	Ensembl:ENSG00000140511	euGenes: HUgn145864
ECgene: HAPLN3	H-InvDB: HAPLN3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HAPLN3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HAPLN3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HAPLN3 gene:
Search GeneIP for patents involving HAPLN3

GeneCards and IP:
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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HAPLN3 Gene

hyaluronan and proteoglycan link protein 3

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HAPLN3 Gene

hyaluronan and proteoglycan link protein 3

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