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HAPLN3 Gene

protein-coding   GIFtS: 49
GCID: GC15M089420

Hyaluronan And Proteoglycan Link Protein 3

(Previous names: extracellular link domain containing, 1)
(Previous symbol: EXLD1)
  Search for HAPLN3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hyaluronan And Proteoglycan Link Protein 31 2
EXLD11 2 3
Extracellular Link Domain Containing, 11 2
HsT198832

External Ids:    HGNC: 214461   Entrez Gene: 1458642   Ensembl: ENSG000001405117   UniProtKB: Q96S863   

Export aliases for HAPLN3 gene to outside databases

Previous GC identifers: GC15M087007 GC15M087150 GC15M087221 GC15M065532


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAPLN3 Gene:
This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this
gene may function in hyaluronic acid binding and cell adhesion. (provided by RefSeq, Jul 2008)

GeneCards Summary for HAPLN3 Gene:
HAPLN3 (hyaluronan and proteoglycan link protein 3) is a protein-coding gene. GO annotations related to this gene include hyaluronic acid binding. An important paralog of this gene is BCAN.

UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86
Function: May function in hyaluronic acid binding




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAPLN3 gene promoter:
         SRF   AML1a   SRF (504 AA)   Pax-2   Pax-2a   MIF-1   E47   Nkx6-1   SEF-1 (1)   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAPLN3 promoter sequence
   Search Chromatin IP Primers for HAPLN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAPLN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

HAPLN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAPLN3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M089420:  view genomic region     (about GC identifiers)

Start:
89,420,519 bp from pter      End:
89,438,857 bp from pter
Size:
18,339 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86 (See protein sequence)
Recommended Name: Hyaluronan and proteoglycan link protein 3 precursor  
Size: 360 amino acids; 40894 Da
Secondary accessions: A8K7P0

Explore the universe of human proteins at neXtProt for HAPLN3: NX_Q96S86

Explore proteomics data for HAPLN3 at MOPED


See HAPLN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_839946.1  
ENSEMBL proteins: 
 ENSP00000352606   ENSP00000456458   ENSP00000457180   ENSP00000456985  

HAPLN3 Human Recombinant Protein Products:

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Novus Biologicals HAPLN3 Protein
Novus Biologicals HAPLN3 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for HAPLN3

 
Search eBioscience for Proteins for HAPLN3 

HAPLN3 Antibody Products:

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ThermoFisher Antibodies for HAPLN3
LSBio Antibodies in human, mouse, rat for HAPLN3

HAPLN3 Assay Products:

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GenScript Custom Assay Services for HAPLN3
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for HAPLN3
Cloud-Clone Corp. CLIAs for HAPLN3
Search eBioscience for ELISAs for HAPLN3 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
VSET: Immunoglobulin superfamily / V-set domain containing

Selected InterPro protein domains (see all 7):
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR000538 Link
 IPR007110 Ig-like_dom
 IPR016187 C-type_lectin_fold

Graphical View of Domain Structure for InterPro Entry Q96S86

ProtoNet protein and cluster: Q96S86

3 Blocks protein domains:
IPB000538 Link domain
IPB003599 Immunoglobulin subtype
IPB013106 Immunoglobulin V-set


UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86
Similarity: Belongs to the HAPLN family
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
Similarity: Contains 2 Link domains


Find genes that share domains with HAPLN3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HPLN3_HUMAN, Q96S86
Function: May function in hyaluronic acid binding

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0005540hyaluronic acid binding IEA--
     
Find genes that share ontologies with HAPLN3           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Hapln3 (no phenotypes)

Find genes that share phenotypes with HAPLN3           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Hapln3tm1Lex for HAPLN3

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAPLN3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HAPLN3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAPLN3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAPLN3

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat HAPLN3 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate HAPLN3:
hsa-miR-3163 hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-29b
SwitchGear 3'UTR luciferase reporter plasmidHAPLN3 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for HAPLN3
Predesigned siRNA for gene silencing in human, mouse, rat HAPLN3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for HAPLN3

Clone
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OriGene clones in human, mouse for HAPLN3 (see all 6)
OriGene ORF clones in mouse, rat for HAPLN3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HAPLN3 (NM_178232)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAPLN3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAPLN3

Cell Line
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GenScript Custom overexpressing Cell Line Services for HAPLN3
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAPLN3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HPLN3_HUMAN, Q96S86: Secreted, extracellular space, extracellular matrix (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
plasma membrane2
cytosol1
endoplasmic reticulum1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005578proteinaceous extracellular matrix IEA--

Find genes that share ontologies with HAPLN3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for HAPLN3 About    
See pathways by source

SuperPathContained pathways About
1Integrin Pathway
FAK1 Signaling0.67
UPA-UPAR Pathway0.56
Integrin Pathway0.67
Inhibition of Angiogenesis by TSP10.50
GnRH Signaling0.56
Transendothelial Migration of Leukocytes0.38
2ERK Signaling
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
ILK Signaling0.49
MAPK Signaling0.58
3Phospholipase-C Pathway
Phospholipase-C Pathway0.56
PTEN Pathway0.56

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HAPLN3 (see all 13)
    MAPK Signaling
Molecular Mechanisms of Cancer
PTEN Pathway
Transendothelial Migration of Leukocytes
UPA-UPAR Pathway


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HAPLN3
Interactions:

    Search GeneGlobe Interaction Network for HAPLN3

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007155cell adhesion IEA--

Find genes that share ontologies with HAPLN3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HAPLN3 (HPLN3)

1 HMDB Compound for HAPLN3    About this table
CompoundSynonyms CAS #PubMed Ids
Hyaluronic acidhyaluronic acid 9004-61-9--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HAPLN3 gene: 
NM_178232.2  

Unigene Cluster for HAPLN3:

Hyaluronan and proteoglycan link protein 3
Hs.447530  [show with all ESTs]
Unigene Representative Sequence: BC053689
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000359595(uc002bnc.3 uc002bnd.3) ENST00000558770(uc002bne.3)
ENST00000562889 ENST00000562281 ENST00000563808
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HAPLN3 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate HAPLN3:
hsa-miR-3163 hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-29b
SwitchGear 3'UTR luciferase reporter plasmidHAPLN3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HAPLN3
Predesigned siRNA for gene silencing in human, mouse, rat HAPLN3
Clone
Products:
     
OriGene clones in human, mouse for HAPLN3 (see all 6)
OriGene ORF clones in mouse, rat for HAPLN3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HAPLN3 (NM_178232)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAPLN3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAPLN3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HAPLN3
OriGene qSTAR qPCR primer pairs in human, mouse for HAPLN3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAPLN3
  QuantiTect SYBR Green Assays in human, mouse, rat HAPLN3
  QuantiFast Probe-based Assays in human, mouse, rat HAPLN3

Additional mRNA sequence: 

AK292055.1 AK292103.1 AY037161.1 AY262759.1 AY358500.1 BC053689.1 BC062320.1 

9 DOTS entries:

DT.40234210  DT.101983664  DT.91684203  DT.121053642  DT.97837286  DT.100672574  DT.100691263  DT.411080 
DT.99950853 

Selected AceView cDNA sequences (see all 79):

CR613805 AY262759 CB216043 BX464704 AL545809 BI771095 NM_178232 BC053689 
AI739142 BQ638707 R72730 BC062320 AA156097 AL571513 AL526824 AY037161 
AA506015 BI762643 BQ014264 BM922473 BG831794 BI823311 BQ574595 BX350098 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for HAPLN3    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1:                                                  -     -               
SP2:                    -     -                       -     -               
SP3:                          -                                             
SP4:                                                                        
SP5:                    -     -                                             


ECgene alternative splicing isoforms for HAPLN3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HAPLN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGGGCACAG
HAPLN3 Expression
About this image


HAPLN3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Bone (Muscoskeletal System)
         HyStem+TGFbeta3+GDF5-induced E15 cells
 
 Cartilage (Muscoskeletal System)
         HyStem+TGFbeta3+GDF5-induced E15 cells
HAPLN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HAPLN3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.447530

UniProtKB/Swiss-Prot: HPLN3_HUMAN, Q96S86
Tissue specificity: Widely expressed with highest levels in spleen and placenta

    Custom PCR Arrays for HAPLN3
Primer
Products:
OriGene qPCR primer pairs and template standards for HAPLN3
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QuantiTect SYBR Green Assays in human, mouse, rat HAPLN3
QuantiFast Probe-based Assays in human, mouse, rat HAPLN3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAPLN3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for HAPLN3 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hapln31 , 5 hyaluronan and proteoglycan link protein 31, 5 81.92(n)1
82.51(a)1
  7 (44.90 cM)5
676661  NM_178255.31  NP_839986.21 
 791170275 
chicken
(Gallus gallus)
Aves HAPLN31 hyaluronan and proteoglycan link protein 3 69.53(n)
61.54(a)
  415495  XM_413868.4  XP_413868.3 
lizard
(Anolis carolinensis)
Reptilia HAPLN36
hyaluronan and proteoglycan link protein 3
53(a)
1 ↔ 1
AAWZ02037182(5851-12963)
African clawed frog
(Xenopus laevis)
Amphibia MGC534952 similar to cartilage link protein 1 73.32(n)    BC046259.1 
zebrafish
(Danio rerio)
Actinopterygii hapln31 hyaluronan and proteoglycan link protein 3 60.1(n)
59.13(a)
  406374  NM_213101.1  NP_998266.1 


ENSEMBL Gene Tree for HAPLN3 (if available)
TreeFam Gene Tree for HAPLN3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HAPLN3 gene
BCAN2  CLEC19A2  NCAN2  HAPLN12  HAPLN42  ACAN2  VCAN2  HAPLN22  
8 SIMAP similar genes for HAPLN3 using alignment to 4 protein entries:     HPLN3_HUMAN (see all proteins):
HAPLN1    HAPLN2    HAPLN4    BCAN    VCAN    ACAN
CSPG3 variant protein    NCAN

Find genes that share paralogs with HAPLN3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HAPLN3 (see all 585)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs720574091,2
C--69162021(+) TTGGG-/GTGGGGG 1 -- int10--------
rs1881981021,2
--89420050(+) ACTGAC/GCTAAG 1 -- ds50010--------
rs1146879661,2
F--89420097(+) GAGGCG/ATTCCT 1 -- ds50011Minor allele frequency- A:0.02WA 118
rs1929597641,2
--89420098(+) AGGCGA/TTCCTG 1 -- ds50010--------
rs1172153961,2
F--89420104(+) TCCTGC/TGCAAG 1 -- ds50011Minor allele frequency- T:0.01EA 120
rs1824203271,2
--89420162(+) GGTGAA/GGCACA 1 -- ds50010--------
rs798539921,2
C,F--89420301(+) GGATGG/TTGAAG 1 -- ds50013Minor allele frequency- T:0.09CSA WA EA 240
rs1442985131,2
C--89420389(+) CCGCAA/GAGTTC 1 -- ds50010--------
rs778208711,2
C,F--89420511(+) CACAGA/GAAAGG 1 -- ds50011Minor allele frequency- G:0.13WA 118
rs1869173181,2
--89420638(+) GGAACC/TGAGAG 1 -- ut310--------

HapMap Linkage Disequilibrium report for HAPLN3 (89420519 - 89438857 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for HAPLN3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv1653CNV Loss18451855
nsv904478CNV Loss21882294

Human Gene Mutation Database (HGMD): HAPLN3
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HAPLN3
DNA2.0 Custom Variant and Variant Library Synthesis for HAPLN3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with HAPLN3           About GenesLikeMe

Human Genome Epidemiology (HuGE) Navigator: HAPLN3 (1 document)

Export disorders for HAPLN3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HAPLN3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with HAPLN3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. (PubMed id 12663660)1, 2, 3, 9 Spicer A.P.... Bowling R.A. Jr. (J. Biol. Chem. 2003)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  4. Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area. (PubMed id 20950796)1 KAohler A.K....Andreassen O.A. (Biol. Psychiatry 2011)
  5. Significant elevation of CLDN16 and HAPLN3 gene expression in human breast cancer. (PubMed id 20664984)1 Kuo S.J....Chen D.R. (Oncol. Rep. 2010)
  6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 145864 HGNC: 21446 AceView: HAPLN3 Ensembl:ENSG00000140511 euGenes: HUgn145864
ECgene: HAPLN3 H-InvDB: HAPLN3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HAPLN3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HAPLN3 gene:
Search GeneIP for patents involving HAPLN3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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