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HAPLN2 Gene

protein-coding   GIFtS: 50
GCID: GC01P156589

Hyaluronan And Proteoglycan Link Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hyaluronan And Proteoglycan Link Protein 21 2
Brain Link Protein 11 2 3
BRAL12 3
Brain Link Protein-12

External Ids:    HGNC: 174101   Entrez Gene: 604842   Ensembl: ENSG000001327027   UniProtKB: Q9GZV73   

Export aliases for HAPLN2 gene to outside databases

Previous GC identifers: GC01P153806 GC01P153402 GC01P154855 GC01P127946


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HAPLN2 Gene:
HAPLN2 (hyaluronan and proteoglycan link protein 2) is a protein-coding gene. Diseases associated with HAPLN2 include rabies, and malignant glioma. GO annotations related to this gene include hyaluronic acid binding. An important paralog of this gene is HAPLN3.

UniProtKB/Swiss-Prot: HPLN2_HUMAN, Q9GZV7
Function: Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of
the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and
general structural stabilization. Binds to hyaluronic acid (By similarity)

Gene Wiki entry for HAPLN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAPLN2 gene promoter:
         AML1a   p53   NRSF form 1   AP-4   NRSF form 2   Evi-1   YY1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAPLN2 promoter sequence
   Search Chromatin IP Primers for HAPLN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAPLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

HAPLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAPLN2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156589:  view genomic region     (about GC identifiers)

Start:
156,589,086 bp from pter      End:
156,595,517 bp from pter
Size:
6,432 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HPLN2_HUMAN, Q9GZV7 (See protein sequence)
Recommended Name: Hyaluronan and proteoglycan link protein 2 precursor  
Size: 340 amino acids; 37775 Da

Explore the universe of human proteins at neXtProt for HAPLN2: NX_Q9GZV7

Explore proteomics data for HAPLN2 at MOPED


See HAPLN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_068589.1  
ENSEMBL proteins: 
 ENSP00000255039   ENSP00000388835  

HAPLN2 Human Recombinant Protein Products:

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Novus Biologicals HAPLN2 Proteins
Novus Biologicals HAPLN2 Lysate
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Browse Sino Biological Cell Lysates
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Cloud-Clone Corp. Proteins for HAPLN2

HAPLN2 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of HAPLN2
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Novus Biologicals HAPLN2 Antibodies
Abcam antibodies for HAPLN2
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ThermoFisher Antibodies for HAPLN2
LSBio Antibodies in human, mouse, rat for HAPLN2

HAPLN2 Assay Products:

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Cloud-Clone Corp. ELISAs for HAPLN2
Cloud-Clone Corp. CLIAs for HAPLN2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
VSET: Immunoglobulin superfamily / V-set domain containing

Selected InterPro protein domains (see all 7):
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR000538 Link
 IPR007110 Ig-like_dom
 IPR016187 C-type_lectin_fold

Graphical View of Domain Structure for InterPro Entry Q9GZV7

ProtoNet protein and cluster: Q9GZV7

3 Blocks protein domains:
IPB000538 Link domain
IPB003599 Immunoglobulin subtype
IPB013106 Immunoglobulin V-set


UniProtKB/Swiss-Prot: HPLN2_HUMAN, Q9GZV7
Similarity: Belongs to the HAPLN family
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
Similarity: Contains 2 Link domains


HAPLN2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HPLN2_HUMAN, Q9GZV7
Function: Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of
the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and
general structural stabilization. Binds to hyaluronic acid (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0005540hyaluronic acid binding IEA--
     
HAPLN2 for ontologies           About GeneDecksing


Phenotypes:
     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hapln2):
 nervous system  vision/eye 

HAPLN2 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAPLN2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HAPLN2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAPLN2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAPLN2

miRNA
Products:
    
miRTarBase miRNAs that target HAPLN2:
hsa-mir-335-5p (MIRT017836)

Block miRNA regulation of human, mouse, rat HAPLN2 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate HAPLN2:
hsa-miR-569 hsa-miR-365 hsa-miR-935 hsa-miR-137 hsa-miR-155
SwitchGear 3'UTR luciferase reporter plasmidHAPLN2 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for HAPLN2
Predesigned siRNA for gene silencing in human, mouse, rat HAPLN2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for HAPLN2

Clone
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OriGene clones in human, mouse for HAPLN2 (see all 5)
OriGene ORF clones in mouse, rat for HAPLN2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HAPLN2 (NM_021817)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAPLN2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAPLN2

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for HAPLN2 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAPLN2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HPLN2_HUMAN, Q9GZV7: Secreted, extracellular space, extracellular matrix (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
cytosol1
lysosome1
mitochondrion1
nucleus1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005578proteinaceous extracellular matrix IEA--

HAPLN2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for HAPLN2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Integrin Pathway
FAK1 Signaling0.67
UPA-UPAR Pathway0.56
Integrin Pathway0.67
Inhibition of Angiogenesis by TSP10.50
GnRH Signaling0.56
Transendothelial Migration of Leukocytes0.38
2ERK Signaling
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
ILK Signaling0.49
MAPK Signaling0.58
3Phospholipase-C Pathway
Phospholipase-C Pathway0.56
PTEN Pathway0.56

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HAPLN2 (see all 13)
    MAPK Signaling
Molecular Mechanisms of Cancer
PTEN Pathway
Transendothelial Migration of Leukocytes
UPA-UPAR Pathway


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HAPLN2
Interactions:

    Search GeneGlobe Interaction Network for HAPLN2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for HAPLN2 (ENSP000002550394) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
BOCENSP000003475464STRING: ENSP00000347546
LRRTM1ENSP000002950574STRING: ENSP00000295057
PDGFRLENSP000002516304STRING: ENSP00000251630
IGFBP7ENSP000002956664STRING: ENSP00000295666
IGFBPL1ENSP000003669234STRING: ENSP00000366923
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007155cell adhesion IEA--

HAPLN2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HAPLN2 (HPLN2)

1 HMDB Compound for HAPLN2    About this table
CompoundSynonyms CAS #PubMed Ids
Hyaluronic acidhyaluronic acid 9004-61-9--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for HAPLN2 gene: 
NM_021817.2  

Unigene Cluster for HAPLN2:

Hyaluronan and proteoglycan link protein 2
Hs.410719  [show with all ESTs]
Unigene Representative Sequence: AK094121
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000255039(uc001fpn.1) ENST00000487988 ENST00000456112(uc010phq.1)
ENST00000482204 ENST00000494218
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HAPLN2 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate HAPLN2:
hsa-miR-569 hsa-miR-365 hsa-miR-935 hsa-miR-137 hsa-miR-155
SwitchGear 3'UTR luciferase reporter plasmidHAPLN2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HAPLN2
Predesigned siRNA for gene silencing in human, mouse, rat HAPLN2
Clone
Products:
     
OriGene clones in human, mouse for HAPLN2 (see all 5)
OriGene ORF clones in mouse, rat for HAPLN2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HAPLN2 (NM_021817)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAPLN2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAPLN2
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HAPLN2
OriGene qSTAR qPCR primer pairs in human, mouse for HAPLN2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAPLN2
  QuantiTect SYBR Green Assays in human, mouse, rat HAPLN2
  QuantiFast Probe-based Assays in human, mouse, rat HAPLN2

Additional mRNA sequence: 

AB049054.1 AK090712.1 AK094121.1 AK293797.1 AK294131.1 AK308805.1 AK308980.1 AK310758.1 
BC029864.1 

12 DOTS entries:

DT.40250642  DT.427521  DT.97817261  DT.121348924  DT.99998042  DT.121348922  DT.75148902  DT.95162717 
DT.100020273  DT.121348907  DT.121348908  DT.121348914 

Selected AceView cDNA sequences (see all 47):

CF457207 BM548424 BM921096 BI489912 AK090712 AI459802 BC029864 NM_021817 
BI821582 BI821339 CB054443 H43809 BM709346 BI757758 AI973128 BM807774 
BM543514 BI824586 R88039 CF456942 CB153631 CB155649 BF594173 AB049054 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for HAPLN2 (see all 15)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a ·
SP1:                                                        -     -                                               -     -     -                                 
SP2:                                                        -     -                                               -     -     -                                 
SP3:                                                                                                              -     -     -                                 
SP4:                                                        -     -     -     -     -     -     -                 -     -     -                                 
SP5:                                                        -     -                                               -     -     -     -     -     -     -         

ExUns: 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7 ^ 8
SP1:                                                      
SP2:                                -                     
SP3:                                                      
SP4:                                                      
SP5:                                                      


ECgene alternative splicing isoforms for HAPLN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HAPLN2 expression in normal human tissues (normalized intensities)      HAPLN2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
HAPLN2 Expression
About this image


HAPLN2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Brain (Nervous System)
         Myelinating Oligodendrocyte Cells Forebrain White Matter
HAPLN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HAPLN2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.410719

UniProtKB/Swiss-Prot: HPLN2_HUMAN, Q9GZV7
Tissue specificity: Expressed only in adult brain

    Custom PCR Arrays for HAPLN2
Primer
Products:
OriGene qPCR primer pairs and template standards for HAPLN2
OriGene qSTAR qPCR primer pairs in human, mouse for HAPLN2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAPLN2
QuantiTect SYBR Green Assays in human, mouse, rat HAPLN2
QuantiFast Probe-based Assays in human, mouse, rat HAPLN2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAPLN2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for HAPLN2 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hapln21 , 5 hyaluronan and proteoglycan link protein 21, 5 87.45(n)1
91.76(a)1
  3 (38.78 cM)5
739401  NM_022031.21  NP_071314.11 
 880217505 
chicken
(Gallus gallus)
Aves HAPLN21 hyaluronan and proteoglycan link protein 2 69.59(n)
67.4(a)
  425975  XM_423654.4  XP_423654.4 
tropical clawed frog
(Xenopus tropicalis)
Amphibia hapln21 hyaluronan and proteoglycan link protein 2 62.86(n)
64.2(a)
  100486153  XM_002941504.2  XP_002941550.2 
zebrafish
(Danio rerio)
Actinopterygii hapln21 hyaluronan and proteoglycan link protein 2 59.6(n)
58.61(a)
  558291  NM_001082816.2  NP_001076285.2 


ENSEMBL Gene Tree for HAPLN2 (if available)
TreeFam Gene Tree for HAPLN2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HAPLN2 gene
HAPLN32  BCAN2  CLEC19A2  NCAN2  HAPLN12  HAPLN42  ACAN2  VCAN2  
8 SIMAP similar genes for HAPLN2 using alignment to 3 protein entries:     HPLN2_HUMAN (see all proteins):
HAPLN3    HAPLN4    BCAN    CSPG3 variant protein    NCAN    HAPLN1
VCAN    ACAN

HAPLN2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HAPLN2 (see all 198)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs751656391,2
C--156587143(+) TGGTTC/TTTTTT 1 -- us2k10--------
rs3711124961,2
C--156587143(+) GTTCT-/TTTTTTT 1 -- us2k10--------
rs46381221,2
C,A--156587232(+) CCTCCC/TGGGTT 1 -- us2k16Minor allele frequency- T:0.00NA WA CSA 10
rs1453374781,2
--156587404(+) CCAAAA/GTGTTG 1 -- us2k10--------
rs1885776111,2
--156587635(+) AACAAC/TTGGGC 1 -- us2k10--------
rs1492275621,2
C--156587696(+) CCTGTA/GTACAA 1 -- us2k10--------
rs1811449891,2
--156587864(+) TGGGCA/GGATTG 1 -- us2k10--------
rs120779551,2
C,F--156587951(+) ttggcG/Atggtg 1 -- us2k14Minor allele frequency- A:0.06NA WA 124
rs75270801,2
C,F,A--156588015(+) ttgaaC/Gccggg 1 -- us2k16Minor allele frequency- G:0.30NA WA CSA EA 364
rs572192641,2
C--156588098(+) AAAAA-/AAAAAA
        
GTTAA
1 -- us2k11Minor allele frequency- AAAAAA:0.00NA 2

HapMap Linkage Disequilibrium report for HAPLN2 (156589086 - 156595517 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for HAPLN2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv521401CNV Loss19592680
nsv872473CNV Loss21882294
nsv523181CNV Loss19592680
nsv824853CNV Gain20364138
nsv824864CNV Gain20364138

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HAPLN2
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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4 diseases for HAPLN2:    About MalaCards
rabies    malignant glioma    schizophrenia    neuronitis


HAPLN2 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: HAPLN2 (1 document)

Export disorders for HAPLN2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HAPLN2 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with HAPLN2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. (PubMed id 11027579)1, 2, 3, 9 Hirakawa S....Ninomiya Y. (Biochem. Biophys. Res. Commun. 2000)
  2. Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. (PubMed id 11873941)1, 3, 9 Nomoto H....Ninomiya Y. (Acta Med. Okayama 2002)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. (PubMed id 12663660)1, 9 Spicer A.P.... Bowling R.A. Jr. (J. Biol. Chem. 2003)
  5. Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area. (PubMed id 20950796)1 KAohler A.K....Andreassen O.A. (Biol. Psychiatry 2011)
  6. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
  7. Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis. (PubMed id 19034380)1 Martins-de-Souza D....Dias-Neto E. (J Neural Transm 2009)
  8. Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas. (PubMed id 19633295)1 Sim H....Viapiano M.S. (J. Biol. Chem. 2009)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 60484 HGNC: 17410 AceView: HAPLN2 Ensembl:ENSG00000132702 euGenes: HUgn60484
ECgene: HAPLN2 H-InvDB: HAPLN2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HAPLN2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HAPLN2 gene:
Search GeneIP for patents involving HAPLN2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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