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Aliases & Descriptions for HAPLN2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BRAL1 2, 3 | | Bral1 1 | | OTTHUMP00000031987 2 |
| | | Descriptions |
|---|
| Brain link protein 1 3 | | brain link protein-1 2 | | hyaluronan and proteoglycan link protein 2 2 |
|
| | Search outside databases for aliases for HAPLN2 genePrevious GC identifers: GC01P153806 GC01P153402 |
Summaries for HAPLN2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: HPLN2_HUMAN, Q9GZV7Function: Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) |
Genomic Location for HAPLN2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HAPLN2 gene 
Entrez Gene cytogenetic band: 1q23.1 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q23.1HAPLN2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P154855:
(about GC identifiers)
Start:
|
154,855,710 bp from pter |
End:
|
154,862,141 bp from pter |
Size:
|
6,432 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for HAPLN2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HPLN2_HUMAN, Q9GZV7 (See
protein sequence)Recommended Name: Hyaluronan and proteoglycan link protein 2 precursor Size: 340 amino acids; 37775 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)REFSEQ proteins: NP_068589.1
ENSEMBL proteins: ENSP00000255039
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005578 | proteinaceous extracellular matrix |
IEA | -- | About this table
Antibodies for HAPLN2: Assays for HAPLN2: | Protein
Domains/ Families for HAPLN2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9GZV7
ProtoNet protein and cluster: Q9GZV7 3 Blocks protein families: IPB000538 Link domain IPB003599 Immunoglobulin subtype IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: HPLN2_HUMAN, Q9GZV7Similarity: Belongs to the HAPLN familySimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domainSimilarity: Contains 2 Link domains | Gene Function for HAPLN2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021817
Applied Biosystems Silencer® siRNAs for HAPLN2
Sigma-Aldrich siRNA for HAPLN2  Sigma-Aldrich shRNA Panels and shRNA for HAPLN2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021817                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021817                                  untagged cDNA clone in CMV expression vector: NM_021817 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_021817
UniProtKB/Swiss-Prot: HPLN2_HUMAN, Q9GZV7Function: Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity)2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005488 | binding |
IEA | -- | | GO:0005540 | hyaluronic acid binding |
IEA | -- | About this table | Pathways & Interactions for HAPLN2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- | About this table
|
Drugs & Compounds for HAPLN2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for HAPLN2
|
Transcripts for HAPLN2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021817
Sigma-Aldrich siRNA for HAPLN2  Sigma-Aldrich shRNA Panels and shRNA for HAPLN2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_021817 REFSEQ mRNAs for HAPLN2 gene: NM_021817.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_021817               OriGene GFP tagged cDNA clone in CMV expression vector: NM_021817                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021817                                  untagged cDNA clone in CMV expression vector: NM_021817  Additional cDNA sequence: AB049054.1 AK090712.1 AK094121.1 AK293797.1 AK294131.1 AK308805.1 AK308980.1 AK310758.1 BC029864.1 12 DOTS entries: DT.40250642 DT.427521 DT.97817261 DT.121348924 DT.99998042 DT.121348922 DT.75148902 DT.95162717 DT.100020273 DT.121348907 DT.121348908 DT.121348914 24/47 AceView cDNA sequences (see all 47
):NM_021817 AI459802 CF457207 BM548424 BC029864 AK090712 BI489912 BM921096 CB153631 BI757253 BM807774 AB049054 R88039 BF594173 BV206517 H43809 BI824586 BI821339 BI757758 BU732720 AI460086 CB054443 BM709346 CF455747
highest scoring ESTs for HAPLN2:AI973128 AB049054 AI423465 AI459802 AI873583 AK090712 AW015789 BC029864 BE857145 BF594173 Unigene Cluster for HAPLN2: Hyaluronan and proteoglycan link protein 2 Hs.410719 [show with all ESTs]Unigene Representative Sequence: AK094121
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for HAPLN2 (see all 15
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | · | 1i | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | · | 2h | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   |
| ExUns: | 5b | · | 5c | · | 5d | · | 5e | · | 5f | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for HAPLN2
1 Ensembl transcript including schematic representation: ENST00000255039
|
Expression for HAPLN2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HAPLN2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HAPLN2
1 / 2 / 3 3 probe-sets matching HAPLN2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.410719 UniProtKB/Swiss-Prot: HPLN2_HUMAN, Q9GZV7Tissue specificity: Expressed only in adult brain |
Orthologs for HAPLN2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HAPLN2 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for HAPLN2
ENSEMBL Gene Tree for HAPLN2 | Paralogs for HAPLN2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for HAPLN2 gene
- HAPLN42 HAPLN12 HAPLN32 NCAN2
|
SNPs/Variants for HAPLN2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HAPLN2 (up to first 250kb)
|
Disorders & Mutations for HAPLN2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for HAPLN2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HAPLN2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for HAPLN2 gene:- The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. (PubMed id 11027579)1, 2, 3, 4 Hirakawa S....Ninomiya Y. (2000)
- Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. (PubMed id 11873941)1, 2, 3 Nomoto H....Ninomiya Y. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. (PubMed id 12663660)1, 3 Spicer A.P.... Bowling R.A. Jr. (2003)
- Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis. (PubMed id 19034380)3 Martins-de-Souza D....Dias-Neto E. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Bral1, a brain-specific link protein, colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems. (PubMed id 11817897)3 Oohashi T....Ninomiya Y. (2002)
|
Search for HAPLN2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HAPLN2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HAPLN2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HAPLN2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HAPLN2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HAPLN2:

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| | | | Search Tocris compounds for HAPLN2 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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