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Aliases for HAPLN2 Gene

Aliases for HAPLN2 Gene

  • Hyaluronan And Proteoglycan Link Protein 2 2 3
  • Brain Link Protein 1 2 3 4
  • BRAL1 3 4
  • Brain Link Protein-1 3

External Ids for HAPLN2 Gene

Summaries for HAPLN2 Gene

GeneCards Summary for HAPLN2 Gene

HAPLN2 (Hyaluronan And Proteoglycan Link Protein 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include hyaluronic acid binding. An important paralog of this gene is HAPLN1.

UniProtKB/Swiss-Prot for HAPLN2 Gene

  • Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).

Gene Wiki entry for HAPLN2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAPLN2 Gene

Genomics for HAPLN2 Gene

Genomic Location for HAPLN2 Gene

Start:
156,619,294 bp from pter
End:
156,625,725 bp from pter
Size:
6,432 bases
Orientation:
Plus strand

Genomic View for HAPLN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAPLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAPLN2 Gene

Regulatory Elements for HAPLN2 Gene

Proteins for HAPLN2 Gene

  • Protein details for HAPLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZV7-HPLN2_HUMAN
    Recommended name:
    Hyaluronan and proteoglycan link protein 2
    Protein Accession:
    Q9GZV7
    Secondary Accessions:
    • Q5T3J0

    Protein attributes for HAPLN2 Gene

    Size:
    340 amino acids
    Molecular mass:
    37775 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HAPLN2 Gene

Proteomics data for HAPLN2 Gene at MOPED

Post-translational modifications for HAPLN2 Gene

No Post-translational modifications

Other Protein References for HAPLN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HAPLN2 Gene

Domains for HAPLN2 Gene

Gene Families for HAPLN2 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Graphical View of Domain Structure for InterPro Entry

Q9GZV7

UniProtKB/Swiss-Prot:

HPLN2_HUMAN
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q9GZV7
  • Contains 2 Link domains.:
    • Q9GZV7
Family:
  • Belongs to the HAPLN family.:
    • Q9GZV7
genes like me logo Genes that share domains with HAPLN2: view

Function for HAPLN2 Gene

Molecular function for HAPLN2 Gene

UniProtKB/Swiss-Prot Function: Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).

Gene Ontology (GO) - Molecular Function for HAPLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IBA --
GO:0005515 protein binding --
GO:0005540 hyaluronic acid binding IBA --
genes like me logo Genes that share ontologies with HAPLN2: view

Phenotypes for HAPLN2 Gene

genes like me logo Genes that share phenotypes with HAPLN2: view

miRNA for HAPLN2 Gene

miRTarBase miRNAs that target HAPLN2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HAPLN2 Gene

Localization for HAPLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAPLN2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAPLN2 Gene COMPARTMENTS Subcellular localization image for HAPLN2 gene
Compartment Confidence
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HAPLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with HAPLN2: view

Pathways for HAPLN2 Gene

genes like me logo Genes that share pathways with HAPLN2: view

Pathways by source for HAPLN2 Gene

Interacting Proteins for HAPLN2 Gene

Gene Ontology (GO) - Biological Process for HAPLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IBA --
GO:0007155 cell adhesion IBA --
GO:0007417 central nervous system development IBA --
GO:0008065 establishment of blood-nerve barrier IEA --
GO:0085029 extracellular matrix assembly IEA --
genes like me logo Genes that share ontologies with HAPLN2: view

Compounds for HAPLN2 Gene

(1) HMDB Compounds for HAPLN2 Gene

Compound Synonyms Cas Number PubMed IDs
Hyaluronic acid
  • hyaluronic acid
9004-61-9
genes like me logo Genes that share compounds with HAPLN2: view

Transcripts for HAPLN2 Gene

Unigene Clusters for HAPLN2 Gene

Hyaluronan and proteoglycan link protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAPLN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - -
SP9: - - - - - - - -
SP10: - -
SP11:
SP12: - - - - -
SP13: -
SP14: - - - - - - -
SP15: - - - - - -

ExUns: 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7 ^ 8
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for HAPLN2 Gene

GeneLoc Exon Structure for
HAPLN2
ECgene alternative splicing isoforms for
HAPLN2

Expression for HAPLN2 Gene

mRNA expression in normal human tissues for HAPLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAPLN2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (18.9) and Brain - Substantia nigra (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HAPLN2 Gene

SOURCE GeneReport for Unigene cluster for HAPLN2 Gene Hs.410719

mRNA Expression by UniProt/SwissProt for HAPLN2 Gene

Q9GZV7-HPLN2_HUMAN
Tissue specificity: Expressed only in adult brain.
genes like me logo Genes that share expressions with HAPLN2: view

Orthologs for HAPLN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAPLN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAPLN2 35
  • 93.39 (n)
  • 90.85 (a)
cow
(Bos Taurus)
Mammalia HAPLN2 35
  • 91.25 (n)
  • 92.33 (a)
HAPLN2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAPLN2 35
  • 90.36 (n)
  • 93.2 (a)
HAPLN2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hapln2 35
  • 87.45 (n)
  • 91.76 (a)
Hapln2 16
Hapln2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HAPLN2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAPLN2 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hapln2 35
  • 88.04 (n)
  • 91.18 (a)
chicken
(Gallus gallus)
Aves HAPLN2 35
  • 69.59 (n)
  • 67.4 (a)
HAPLN2 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hapln2 35
  • 62.86 (n)
  • 64.2 (a)
zebrafish
(Danio rerio)
Actinopterygii hapln2 35
  • 59.6 (n)
  • 58.61 (a)
hapln2 36
  • 53 (a)
OneToOne
Species with no ortholog for HAPLN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAPLN2 Gene

ENSEMBL:
Gene Tree for HAPLN2 (if available)
TreeFam:
Gene Tree for HAPLN2 (if available)

Paralogs for HAPLN2 Gene

Paralogs for HAPLN2 Gene

Selected SIMAP similar genes for HAPLN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HAPLN2: view

Variants for HAPLN2 Gene

Sequence variations from dbSNP and Humsavar for HAPLN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1135645 -- 156,625,595(+) ATGCA(A/G)AGGTG utr-variant-3-prime, downstream-variant-500B
rs1135646 -- 156,625,655(+) CGCCG(A/G)GGGGA utr-variant-3-prime
rs4661206 -- 156,626,225(+) TTGCG(G/T)AAGGC downstream-variant-500B
rs12045494 -- 156,625,836(+) AGCAC(C/T)TAAGA downstream-variant-500B
rs12405992 -- 156,624,572(+) CCTCT(C/T)ATCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAPLN2 Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV Loss 19592680
nsv872473 CNV Loss 21882294
nsv824853 CNV Gain 20364138
nsv521401 CNV Loss 19592680
nsv824864 CNV Gain 20364138

Relevant External Links for HAPLN2 Gene

HapMap Linkage Disequilibrium report
HAPLN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAPLN2 Gene

Disorders for HAPLN2 Gene

Relevant External Links for HAPLN2

Human Genome Epidemiology (HuGE) Navigator
HAPLN2
genes like me logo Genes that share disorders with HAPLN2: view

No data available for UniProtKB/Swiss-Prot for HAPLN2 Gene

Publications for HAPLN2 Gene

  1. The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. (PMID: 11027579) Hirakawa S. … Ninomiya Y. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. (PMID: 11873941) Nomoto H. … Ninomiya Y. (Acta Med. Okayama 2002) 2 3 23
  3. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. (PMID: 12663660) Spicer A.P. … Bowling R.A. Jr. (J. Biol. Chem. 2003) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HAPLN2 Gene

Sources for HAPLN2 Gene

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