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HAPLN1 Gene

protein-coding GIFtS: 56

GC05M082972

hyaluronan and proteoglycan link protein 1
(Previous name: cartilage linking protein 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CRTL1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CRTL1 ^², ³
LP ^³
OTTHUMP00000147586 ^²

Descriptions
Cartilage link protein ^², ³
Proteoglycan link protein ^³
cartilage linking protein 1 ^¹, ²
hyaluronan and proteoglycan link protein 1 ^²

External Ids
HGNC: 2380¹
Entrez Gene: 1404²
UniProtKB: P10915³
Ensembl: ENSG00000145681⁷

Search outside databases for aliases for HAPLN1 gene

Previous GC identifer: GC05M083020

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HPLN1_HUMAN, P10915

Function: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the

extracellular cartilage matrix

Gene Wiki entry for HAPLN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HAPLN1 gene

Entrez Gene cytogenetic band: 5q14.3 Ensembl cytogenetic band: 5q14.3 HGNC cytogenetic band: 5q14.3

HAPLN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M082972: (about GC identifiers)

Start:	82,972,493 bp from pter
End:	83,052,454 bp from pter
Size:	79,962 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_006713.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HPLN1_HUMAN, P10915 (See protein sequence)

Recommended Name: Hyaluronan and proteoglycan link protein 1 precursor

Size: 354 amino acids; 40166 Da

Subcellular location: Secreted, extracellular space, extracellular matrix

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001875.1

ENSEMBL proteins:

ENSP00000274341 ENSP00000369486

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for HAPLN1
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HAPLN1)
	Human Recombinant Proteins from Abnova (HAPLN1)

OriGene Purified Recombinant Human Protein: HAPLN1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	TAS	2286376

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Antibodies for HAPLN1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HAPLN1
	R&D Systems Antibodies for HAPLN1
	Antibodies from Abcam (HAPLN1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HAPLN1)
	Novus Biologicals Antibodies for HAPLN1

Assays for HAPLN1:

	Invitrogen Assays for HAPLN1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P10915

ProtoNet protein and cluster: P10915

3 Blocks protein families:

IPB000538 Link domain

IPB003596 Immunoglobulin V-type

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: HPLN1_HUMAN, P10915

Similarity: Belongs to the HAPLN family

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

Similarity: Contains 2 Link domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAPLN1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001884

Applied Biosystems Silencer® siRNAs for HAPLN1

Sigma-Aldrich siRNA for HAPLN1

Sigma-Aldrich shRNA Panels and shRNA for HAPLN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HAPLN1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001884
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001884
untagged cDNA clone in CMV expression vector: NM_001884

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001884

UniProtKB/Swiss-Prot: HPLN1_HUMAN, P10915

Function: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the

extracellular cartilage matrix

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hapln1):

craniofacial	growth/size	hearing/vestibular/ear	lethality-prenatal/perinatal	limbs/digits/tail
skeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	IEA	--
GO:0005540	hyaluronic acid binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/17 Interacting proteins for HAPLN1 (ENSP00000274341³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COMP	ENSP00000222271³	STRING (score=.935)
SOX9	ENSP00000245479³	STRING (score=.919)
COL11A1	ENSP00000351163³	STRING (score=.893)
COL9A2	ENSP00000361834³	STRING (score=.885)
COL2A1	ENSP00000346511³	STRING (score=.86)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HAPLN1
5 Novoseek chemical compound relationships for HAPLN1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neurocan	80.90	4	15062856 (3), 8907541 (1)
keratan sulfate	51.88	5	10088776 (2)
chondroitin sulfate	42.14	2	12888576 (1)
glycosaminoglycan	37.16	1	12431185 (1)
tyrosine	0.00	1	1356634 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAPLN1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001884

Sigma-Aldrich siRNA for HAPLN1

Sigma-Aldrich shRNA Panels and shRNA for HAPLN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001884

REFSEQ mRNAs for HAPLN1 gene:

NM_001884.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001884

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001884
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001884
                                 untagged cDNA clone in CMV expression vector: NM_001884

Additional cDNA sequence:

AK313713.1 BC057808.1 CR597704.1 CR605965.1 M63579.1 U43328.1 X17405.1 X78075.1

X78076.1

5 DOTS entries:

DT.117144 DT.95367165 DT.100019919 DT.100843660 DT.120797267

24/128 AceView cDNA sequences (see all 128 ):

M63579 BQ183835 BU735930 BX396679 BF589298 CB157941 CN485077 AU117138

CR605965 BX282759 CB132999 AI052715 BQ573708 BI493085 CA412730 BI493084

AU117728 CA413596 CA412005 AI494580 CR597704 CA414697 AA664475 BQ573867

highest scoring ESTs for HAPLN1:

U43328 AA115901 AU117138 AU117728 AU119529 AU279695 BG283479 BX282759 CB143656 CB146759

Unigene Cluster for HAPLN1:

Hyaluronan and proteoglycan link protein 1

Hs.2799 [show with all ESTs]

Unigene Representative Sequence: NM_001884

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HAPLN1 (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8a	·	8b
SP1:			-		-		-		-
SP2:									-
SP3:
SP4:					-		-		-
SP5:							-		-

About this scheme

ECgene alternative splicing isoforms for HAPLN1

2 Ensembl transcripts including schematic representations:

ENST00000274341 ENST00000380141

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HAPLN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HAPLN1

¹ / ² / ³

11 probe-sets matching HAPLN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56031_at²^{, 3}	U95-B	1	1.00	1.00	0.88	1.25	AI278618	0.40	1.00	0.76	1
51037_at²^{, 3}	U95-B	1	1.00	1.00	0.81	0.78	AI760252	0.20	1.00	0.72	1
39618_at²^{, 3}	U95-A	1	1.00	1.00	0.55	0.47	U43328	1.00	1.00	1.00	1
205524_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001884	0.60	1.00	0.82	1
230204_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU144114	0.20	1.00	0.72	1
205523_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U43328	1.00	1.00	1.00	1
230895_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AI760252	0.20	1.00	0.72	1
205524_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230204_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205523_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230895_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks HAPLN1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.2799
Expression variation in blood from EXPOLDB for HAPLN1
UniProtKB/Swiss-Prot: HPLN1_HUMAN, P10915
Tissue specificity: Widely expressed. Weakly expressed in the brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HAPLN1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HAPLN1¹	--	hyaluronan and proteoglycan link protein 1	93.13(n) 95.48(a)	488921 XM_546038.2 XP_546038.2
chimpanzee (Pan troglodytes)	HAPLN1¹	--	hyaluronan and proteoglycan link protein 1	99.72(n) 99.44(a)	461765 XM_001146947.1 XP_001146947.1
cow (Bos taurus)	HAPLN1¹	--	hyaluronan and proteoglycan link protein 1	92.84(n) 96.33(a)	281717 NM_174288.1 NP_776713.1
rat (Rattus norvegicus)	Hapln1¹	--	hyaluronan and proteoglycan link protein 1	88.89(n) 95.48(a)	29331 NM_019189.1 NP_062062.1
mouse (Mus musculus)	Hapln1^{1, 5}	13 (44.00 cM)⁵	hyaluronan and proteoglycan link protein 1^{1, 5}	89.08(n)¹ 96.05(a)¹	12950¹ NM_013500.3¹ NP_038528.2¹ AA008559⁵ AF098460⁵ (see all 18)

About this table Species with no ortholog for HAPLN1

ENSEMBL Gene Tree for HAPLN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HAPLN1 gene

HAPLN4² HAPLN3² NCAN² HAPLN2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/477 NCBI SNPs in HAPLN1 are shown (see all 477 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 162)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7706851^1,2	A,C,F,H	82970310(+)	`ACAAAT/CGCCAT`	1	--	ut3¹		7		NA EU EA WA	530
	rs1345420^1,2	A,C,F,H	82970000(-)	`GTATCA/GTAGCT`	1	--	ut3¹ ese³		12		MN NA EU EA WA	1108
	rs6864342^1,2	A,C,F,H	82973294(+)	`CATCAT/CTGAGA`	1	S/N	mis¹		12		EU EA WA	1256
	rs17206075^1,2	C,F,H	82971357(+)	`TGTCAT/CCTTTT`	1	--	ut3¹		7		NA EU EA WA	562
	rs11955113^1,2	C,F,H	82972663(+)	`TAATTT/AGTTTA`	1	--	ut3¹		4		EU EA WA	420
	rs7731588^1,2	C,F,H	82970852(+)	`AAGATT/ATTTTG`	1	--	ut3¹		4		EU EA WA	414
--	rs12521652^1,2	A,C	83054186(+)	`GAGAGA/GTTGCA`	1	--	ng3¹		0	--	--	--	--
--	rs3734092^1,2	C,F	83052499(-)	`CACACA/G/TCACAC`	1	--	ut5¹ ese³		1		EA	1484
	rs1047585^1,2	A,F	82969829(-)	`GTTTTC/GATTTT`	1	--	ut3¹		1		MN	184
	rs16900697^1,2	F,H	82972295(+)	`TTAAAT/CACAAC`	1	--	ut3¹		7		NA EU EA WA	562

About this table

HapMap Linkage Disequilibrium images for HAPLN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 115435

6 Novoseek disease relationships for HAPLN1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
osteoarthritis	44.51	5	10088776 (2), 8000735 (1), 9336408 (1)
arthritis juvenile rheumatoid	35.13	3	9150089 (2), 1643745 (1)
arthritis	27.65	8	7632088 (1), 12951872 (1), 12928112 (1)
rheumatoid arthritis	21.10	2	9712087 (2)
necrosis	0.00	1	9882571 (1)
tumors	0.00	1	9882571 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/78 PubMed articles for HAPLN1 gene (see all 78 ):

Complete amino acid sequence of human cartilage link protein (CRTL1) deduced from cDNA clones and chromosomal assignment of the gene. (PubMed id 2286376)^{1, 2, 3, 4} Osborne-Lawrence S.L.... Duby A.D. (1990)
The primary structure of human cartilage link protein. (PubMed id 2320422)^{2, 3, 4} Dudhia J. and Hardingham T.E. (1990)
A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. (PubMed id 12663660)^{1, 3, 4} Spicer A.P.... Bowling R.A. Jr. (2003)
The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. (PubMed id 11027579)^{1, 3, 4} Hirakawa S....Ninomiya Y. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of the promoter for the rat and human link protein gene. (PubMed id 2030970)^{3, 4} Rhodes C....Yamada Y. (1991)
The primary structure of human cartilage link protein. (PubMed id 2336413)^{3, 4} Dudhia J. and Hardingham T.E. (1990)
Production of cartilage link protein by human granulosa-lutein cells. (PubMed id 12429048)^{1, 3} Sun G.W....Terao T. (2002)
SOX9-dependent and -independent transcriptional regulation of human cartilage link protein. (PubMed id 15456769)^{1, 3} Kou I. and Ikegawa S. (2004)
Distinct interaction of versican/PG-M with hyaluronan and link protein. (PubMed id 12888576)^{1, 3} Matsumoto K....Watanabe H. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1404	HGNC: 2380	AceView: HAPLN1	Ensembl:ENSG00000145681	euGenes: HUgn1404
ECgene: HAPLN1	H-InvDB: HAPLN1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for HAPLN1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for HAPLN1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HAPLN1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HAPLN1		Antibodies for HAPLN1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HAPLN1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for HAPLN1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HAPLN1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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HAPLN1 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for HAPLN1

Summaries
for HAPLN1

Genomic Location
for HAPLN1

Proteins
for HAPLN1

Protein Domains/
Families
for HAPLN1

Gene Function
for HAPLN1

Pathways & Interactions
for HAPLN1

Drugs & Compounds
for HAPLN1

Transcripts
for HAPLN1

Expression
for HAPLN1

Orthologs
for HAPLN1

Paralogs
for HAPLN1

SNPs/Variants
for HAPLN1

Disorders & Mutations
for HAPLN1

Medical News
for HAPLN1

Publications
for HAPLN1

Search for HAPLN1

Genome Databases showing HAPLN1

Other Databases showing HAPLN1

Specialized Databases showing HAPLN1

Licensable Technologies
for HAPLN1

Services
for HAPLN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HAPLN1 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor HAPLN1

Summariesfor HAPLN1

Genomic Locationfor HAPLN1

Proteinsfor HAPLN1

Protein Domains/Familiesfor HAPLN1

Gene Functionfor HAPLN1

Pathways & Interactionsfor HAPLN1

Drugs & Compoundsfor HAPLN1

Transcriptsfor HAPLN1

Expression for HAPLN1

Orthologsfor HAPLN1

Paralogsfor HAPLN1

SNPs/Variantsfor HAPLN1

Disorders & Mutationsfor HAPLN1

Medical Newsfor HAPLN1

Publicationsfor HAPLN1

Search for HAPLN1

Genome Databases showing HAPLN1

Other Databases showing HAPLN1

Specialized Databases showing HAPLN1

Licensable Technologiesfor HAPLN1

Servicesfor HAPLN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HAPLN1

Summaries
for HAPLN1

Genomic Location
for HAPLN1

Proteins
for HAPLN1

Protein Domains/
Families
for HAPLN1

Gene Function
for HAPLN1

Pathways & Interactions
for HAPLN1

Drugs & Compounds
for HAPLN1

Transcripts
for HAPLN1

Expression
for HAPLN1

Orthologs
for HAPLN1

Paralogs
for HAPLN1

SNPs/Variants
for HAPLN1

Disorders & Mutations
for HAPLN1

Medical News
for HAPLN1

Publications
for HAPLN1

Licensable Technologies
for HAPLN1

Services
for HAPLN1