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Aliases for HAO2 Gene

Aliases for HAO2 Gene

  • Hydroxyacid Oxidase 2 2 3 5
  • Long-Chain L-2-Hydroxy Acid Oxidase 2 3 4
  • (S)-2-Hydroxy-Acid Oxidase, Peroxisomal 3 4
  • Cell Growth-Inhibiting Gene 16 Protein 3 4
  • Long Chain Alpha-Hydroxy Acid Oxidase 3 4
  • Hydroxyacid Oxidase 2 (Long Chain) 2 3
  • Glycolate Oxidase 2 3
  • HAOX2 3 4
  • Growth-Inhibiting Protein 16 2
  • (S)-2-Hydroxy-Acid Oxidase 2
  • EC 4
  • GIG16 3

External Ids for HAO2 Gene

Previous GeneCards Identifiers for HAO2 Gene

  • GC01P120358
  • GC01P118749
  • GC01P119058
  • GC01P119257
  • GC01P119623
  • GC01P119712
  • GC01P119913
  • GC01P117769

Summaries for HAO2 Gene

Entrez Gene Summary for HAO2 Gene

  • This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for HAO2 Gene

HAO2 (Hydroxyacid Oxidase 2) is a Protein Coding gene. Among its related pathways are Peroxisome and Carbon metabolism. GO annotations related to this gene include receptor binding and FMN binding. An important paralog of this gene is HAO1.

UniProtKB/Swiss-Prot for HAO2 Gene

  • Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAO2 Gene

Genomics for HAO2 Gene

Regulatory Elements for HAO2 Gene

Enhancers for HAO2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G119339 1 ENCODE 11.2 -27.6 -27593 2.8 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 MIER2 PPARG KAT8 HAO2-IT1 HAO2 PIR50994 PIR56417
GH01G119327 1 ENCODE 10.9 -41.4 -41434 1.6 PKNOX1 ARNT ARID4B FEZF1 DMAP1 ZNF2 ZNF48 ZNF121 GLIS2 ZNF143 HAO2 HAO2-IT1 ENSG00000227712 LINC01780
GH01G119278 0.8 ENCODE 11.7 -88.9 -88885 1.9 GTF2F1 JUN MAX RFX5 TEAD3 HIC1 CTBP1 FOSL2 FOS TCF7L2 HAO2 HAO2-IT1 RNU1-75P WARS2 GC01P119270 ENSG00000227712
GH01G119397 0.5 ENCODE 16.5 +29.4 29355 1.6 ESRRA FOXA2 ZNF740 HNF4A PRDM1 HAO2 HAO2-IT1 TBX15 HSD3B2
GH01G119428 0.8 ENCODE 10.3 +60.6 60555 2.4 INSM2 FEZF1 HIC1 ZNF316 ZNF366 SCRT2 ZNF169 ZSCAN5C MAFK SCRT1 HAO2 HAO2-IT1 GAPDHP74 HSD3B2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HAO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HAO2 Gene

119,368,776 bp from pter
119,394,130 bp from pter
25,355 bases
Plus strand

Genomic View for HAO2 Gene

Genes around HAO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAO2 Gene

Proteins for HAO2 Gene

  • Protein details for HAO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hydroxyacid oxidase 2
    Protein Accession:
    Secondary Accessions:
    • Q2TU86
    • Q5QP00
    • Q9UJS6

    Protein attributes for HAO2 Gene

    351 amino acids
    Molecular mass:
    38839 Da
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    • Homotetramer or homooctamer.

    Alternative splice isoforms for HAO2 Gene


neXtProt entry for HAO2 Gene

Post-translational modifications for HAO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HAO2 Gene

Domains & Families for HAO2 Gene

Suggested Antigen Peptide Sequences for HAO2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
  • Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
genes like me logo Genes that share domains with HAO2: view

No data available for Gene Families for HAO2 Gene

Function for HAO2 Gene

Molecular function for HAO2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.

Enzyme Numbers (IUBMB) for HAO2 Gene

Gene Ontology (GO) - Molecular Function for HAO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003973 (S)-2-hydroxy-acid oxidase activity IEA,IDA 10777549
GO:0005102 receptor binding IPI 20178365
GO:0010181 FMN binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0052852 very-long-chain-(S)-2-hydroxy-acid oxidase activity IEA --
genes like me logo Genes that share ontologies with HAO2: view
genes like me logo Genes that share phenotypes with HAO2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HAO2

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAO2 Gene

Localization for HAO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAO2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HAO2 gene
Compartment Confidence
extracellular 5
peroxisome 5
cytoskeleton 2
mitochondrion 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HAO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IEA,IDA 10777549
GO:0005782 peroxisomal matrix TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HAO2: view

Pathways & Interactions for HAO2 Gene

genes like me logo Genes that share pathways with HAO2: view

Gene Ontology (GO) - Biological Process for HAO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009062 fatty acid catabolic process TAS --
GO:0019395 fatty acid oxidation IDA 10777549
GO:0044255 cellular lipid metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HAO2: view

No data available for SIGNOR curated interactions for HAO2 Gene

Drugs & Compounds for HAO2 Gene

(4) Drugs for HAO2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Flavin Mononucleotide Experimental Pharma Target 6
Glycolic acid Experimental Pharma 16
Hydrogen peroxide Pharma 63

(1) Additional Compounds for HAO2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glyoxylic acid
  • a-Ketoacetate
  • a-Ketoacetic acid
  • alpha-Ketoacetate
  • alpha-Ketoacetic acid
  • Formylformate
genes like me logo Genes that share compounds with HAO2: view

Transcripts for HAO2 Gene

Unigene Clusters for HAO2 Gene

Hydroxyacid oxidase 2 (long chain):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
SP2: -
SP3: - -
SP4: - -

Relevant External Links for HAO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HAO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HAO2 Gene

mRNA differential expression in normal tissues according to GTEx for HAO2 Gene

This gene is overexpressed in Liver (x37.8) and Kidney - Cortex (x13.1).

Protein differential expression in normal tissues from HIPED for HAO2 Gene

This gene is overexpressed in Lung (28.0), Kidney (24.9), and Liver (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HAO2 Gene

Protein tissue co-expression partners for HAO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HAO2 Gene:


SOURCE GeneReport for Unigene cluster for HAO2 Gene:


mRNA Expression by UniProt/SwissProt for HAO2 Gene:

Tissue specificity: Liver and kidney.

Evidence on tissue expression from TISSUES for HAO2 Gene

  • Liver(4.7)
  • Kidney(4.6)
genes like me logo Genes that share expression patterns with HAO2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for HAO2 Gene

Orthologs for HAO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HAO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HAO2 34 35
  • 99.72 (n)
(Canis familiaris)
Mammalia HAO2 34 35
  • 85.75 (n)
(Bos Taurus)
Mammalia HAO2 34 35
  • 82.72 (n)
(Rattus norvegicus)
Mammalia Hao2 34
  • 79.87 (n)
(Mus musculus)
Mammalia Hao2 34 16 35
  • 78.63 (n)
(Ornithorhynchus anatinus)
Mammalia HAO2 35
  • 47 (a)
(Gallus gallus)
Aves HAO2 34 35
  • 63.72 (n)
(Anolis carolinensis)
Reptilia HAO2 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hao2 34
  • 63.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398510 34
(Danio rerio)
Actinopterygii hao2 34 35
  • 63.31 (n)
zgc63690 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.904 34
fruit fly
(Drosophila melanogaster)
Insecta CG18003 36 35
  • 46 (a)
(Caenorhabditis elegans)
Secernentea F41E6.5 36 35
  • 40 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02640g 34
  • 50.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYB2 34 35
  • 48.84 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G14150 34
  • 51.9 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2092 34
(Oryza sativa)
Liliopsida Os07g0616500 34
  • 51.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7836 35
  • 52 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08272 34
  • 49.85 (n)
Species where no ortholog for HAO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HAO2 Gene

Gene Tree for HAO2 (if available)
Gene Tree for HAO2 (if available)

Paralogs for HAO2 Gene

Paralogs for HAO2 Gene

(1) SIMAP similar genes for HAO2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HAO2: view

Variants for HAO2 Gene

Sequence variations from dbSNP and Humsavar for HAO2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000039917 -- 119,376,954(+) TTCCC(C/T)ATTGT intron-variant
rs1000098938 -- 119,374,373(+) ACAAT(G/T)CCATG intron-variant
rs1000172988 -- 119,373,029(+) TTCTC(A/G)AATGA intron-variant
rs1000244644 -- 119,382,715(+) GGTGT(C/T)GGAAG intron-variant
rs1000249025 -- 119,390,649(+) AAAAT(A/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAO2 Gene

Variant ID Type Subtype PubMed ID
esv1759268 CNV insertion 17803354
esv2761649 CNV gain 21179565
esv2763647 CNV gain+loss 21179565
esv34089 CNV loss 18971310
nsv1004662 CNV gain 25217958
nsv2599 CNV deletion 18451855
nsv524681 CNV gain 19592680

Variation tolerance for HAO2 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAO2 Gene

Disorders for HAO2 Gene

Relevant External Links for HAO2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HAO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAO2 Gene

Publications for HAO2 Gene

  1. Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. (PMID: 10777549) Jones J.M. … Gould S.J. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for HAO2 Gene

Sources for HAO2 Gene

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