Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HAO2 Gene

protein-coding   GIFtS: 56
GCID: GC01P119913

hydroxyacid oxidase 2 (long chain)

 Explore 10 diseases affiliated with
HAO2 via our new
 Human Malady Compendium 
Biological research products
for HAO2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Hydroxyacid Oxidase 2 (Long Chain)1 2     Long-Chain L-2-Hydroxy Acid Oxidase2 3
HAOX21 2 3 5     (S)-2-Hydroxy-Acid Oxidase, Peroxisomal2 3
GIG161 2     Glycolate Oxidase2
Cell Growth-Inhibiting Gene 16 Protein2 3     Hydroxyacid Oxidase 22
Long Chain Alpha-Hydroxy Acid Oxidase2 3     EC 1.1.3.153

External Ids:    HGNC: 48101   Entrez Gene: 511792   Ensembl: ENSG000001168827   OMIM: 6051765   UniProtKB: Q9NYQ33   

Export aliases for HAO2 gene to outside databases

Previous GC identifers: GC01P120358 GC01P118749 GC01P119058 GC01P119257 GC01P119623 GC01P119712 GC01P117769


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HAO2:
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino
acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the
peroxisome. Specifically, this gene is expressed predominantly in liver and kidney and has the highest activity toward
the substrate 2-hydroxypalmitate. Two alternatively spliced variants encoding the same isoform have been described.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3
Function: Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HAO2 gene promoter:
         SRF   C/EBPbeta   PPAR-gamma1   AML1a   SRF (504 AA)   ARP-1   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HAO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3-p13.1   Ensembl cytogenetic band:  1p12   HGNC cytogenetic band: 1p13.3-p13.1

HAO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAO2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P119913:  view genomic region     (about GC identifiers)

Start:
119,911,402 bp from pter      End:
119,936,753 bp from pter
Size:
25,352 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3 (See protein sequence)
Recommended Name: Hydroxyacid oxidase 2  
Size: 351 amino acids; 38839 Da
Cofactor: FMN
Subunit: Homotetramer or homooctamer (By similarity)
Subcellular location: Peroxisome
Secondary accessions: Q2TU86 Q9UJS6

Explore the universe of human proteins at neXtProt for HAO2: NX_Q9NYQ3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYQ3

  • HAO2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005783.1  NP_057611.1  

    ENSEMBL proteins: 
     ENSP00000393955   ENSP00000354314   ENSP00000316339  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HAO2
    OriGene Protein Over-expression Lysate (see all 3): HAO2
    OriGene Custom Protein Services for HAO2 
    GenScript Custom Purified and Recombinant Proteins Services for HAO2
    Novus Biologicals HAO2 Protein
    Novus Biologicals HAO2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HAO2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome IDA10777549


    HAO2 for ontologies           About GeneDecksing



    HAO2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HAO2 
    GenScript Custom Superior Antibodies Services for HAO2
    Novus Biologicals HAO2 Antibodies
    Search for Antibodies for HAO2 at Abcam  
    Uscn Antibodies for HAO2
    Search ThermoFisher Antibodies for HAO2

    Assay Products for HAO2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HAO2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HAO2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HAO2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013785 Aldolase_TIM
     IPR012133 Alpha-hydoxy_acid_DH_FMN
     IPR000262 FMN-dep_DH
     IPR008259 FMN_hydac_DH_AS

    Graphical View of Domain Structure for InterPro Entry Q9NYQ3

    ProtoNet protein and cluster: Q9NYQ3

    1 Blocks protein family: IPB000262 FMN-dependent alpha-hydroxy acid dehydrogenase

    UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3
    Similarity: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family
    Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3
    Function: Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids
    Catalytic activity: (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2)

    Enzyme Number (IUBMB): EC 1.1.3.151

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): HAO2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAO2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HAO2
    SwitchGear 3'UTR luciferase reporter plasmidHAO2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAO2 (see all 4)
    OriGene shRNA RFP: HAO2
    OriGene siRNA: HAO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAO2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HAO2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAO2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAO2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HAO2 (NM_016527)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAO2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HAO2
    Search LifeMap BioReagents cell lines for HAO2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAO2

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003973(S)-2-hydroxy-acid oxidase activity IDA10777549
    GO:0005102receptor binding IPI--
    GO:0010181FMN binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0052852very-long-chain-(S)-2-hydroxy-acid oxidase activity IEA--


    HAO2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HAO2:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Peroxisome
    Peroxisome1.00
    2Glyoxylate and dicarboxylate metabolism
    Glyoxylate and dicarboxylate metabolism1.00
    3Metabolism
    Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    3         Kegg Pathways  (Kegg details for HAO2):
        Glyoxylate and dicarboxylate metabolism
    Metabolic pathways
    Peroxisome


    HAO2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HAO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for HAO2 (ENSP000003163394) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRHPRENSP000003134324STRING: ENSP00000313432
    PGPENSP000003309184STRING: ENSP00000330918
    AGXTENSP000003026204STRING: ENSP00000302620
    AGXT2ENSP000002314204STRING: ENSP00000231420
    DAOENSP000002284764STRING: ENSP00000228476
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018924mandelate metabolic process IEA--
    GO:0019395fatty acid oxidation IDA10777549
    GO:0051260protein homooligomerization IEA--


    HAO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HAO2

    5 HMDB Compounds for HAO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Flavin MononucleotideFMN (see all 19)146-17-8--
    Glycolic acid2-Hydroxyacetate (see all 18)79-14-1--
    Glyoxylic acidFormylformate (see all 16)298-12-4--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    OxygenOxygen (see all 5)7782-44-7--

    1 DrugBank Compound for HAO2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Riboflavin Monophosphate-- 146-17-8target--10592235

    Search CenterWatch for drugs/clinical trials and news about HAO2 / HAOX2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HAO2 gene (2 alternative transcripts): 
    NM_001005783.1  NM_016527.2  

    Unigene Cluster for HAO2:

    Hydroxyacid oxidase 2 (long chain)
    Hs.659767  [show with all ESTs]
    Unigene Representative Sequence: AK298289
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457318 ENST00000361035(uc001ehq.1 uc001ehr.1) ENST00000325945
    ENST00000482991

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): HAO2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAO2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HAO2
    SwitchGear 3'UTR luciferase reporter plasmidHAO2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAO2 (see all 4)
    OriGene shRNA RFP: HAO2
    OriGene siRNA: HAO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAO2
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAO2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAO2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HAO2 (NM_016527)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAO2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAO2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HAO2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAO2

    Additional cDNA sequence: 

    AF203975.1 AF231917.1 AK298289.1 AY513277.1 BC020863.1 

    6 DOTS entries:

    DT.40123369  DT.100784731  DT.100019080  DT.91711673  DT.100784732  DT.95246230 

    24/62 AceView cDNA sequences (see all 62):

    BG564465 BE464431 AA969532 AW139221 AI733261 AW299779 AI373640 CB146648 
    CB147151 AI572851 AW613512 BG674888 BG431374 CB146686 AW001794 BI760034 
    CB121424 BG402318 BG428569 AI793285 W78813 BI765772 AA962446 AW771613 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HAO2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                                                                                                
    SP2:                    -                                                                           
    SP3:                    -                 -                                                         
    SP4:                                                        -     -                                 


    ECgene alternative splicing isoforms for HAO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HAO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTTCTTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    HAO2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisTestis InterstitiumTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HAO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HAO2

    SOURCE GeneReport for Unigene cluster: Hs.659767

    UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3
    Tissue specificity: Liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including HAO2: 
              Hepatotoxicity in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAO2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HAO2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAO2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAO2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for HAO2 gene from 9/31 species (see all 31)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HAO21 hydroxyacid oxidase 2 (long chain) 63.63(n)
    60.11(a)
      418311  XM_416535.3  XP_416535.3 
    lizard
    (Anolis carolinensis)
    Reptilia HAO26
    --
    59(a)
    1 ↔ 1
    GL343218.1(430597-442034)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985102 hypothetical protein LOC398510 72.59(n)    BC044114.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636902 hypothetical protein MGC63690 73.77(n)   393455  BC055205.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F41E6.53 glycolate oxidase 40(a)   V(8606190-8607675)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CYB21 Cyb2p 48.74(n)
    40.41(a)
      854950   NP_013658.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G141501 Aldolase-type TIM barrel family protein 51.9(n)
    48.98(a)
      820632  NM_001084683.1  NP_001078152.1 
    rice
    (Oryza sativa)
    Liliopsida AK068129.12   -- 69.25(n)    AK068129.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria lldD6
    L-lactate dehydrogenase, FMN-linked
    30(a)
    possible ortholog
    Chromosome(3777850-3779040)


    ENSEMBL Gene Tree for HAO2 (if available)
    TreeFam Gene Tree for HAO2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HAO2 gene
    HAO12  
    1 SIMAP similar gene for HAO2 using alignment to 3 protein entries:     HAOX2_HUMAN (see all proteins):
    HAO1

    HAO2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/583 NCBI SNPs in HAO2 are shown (see all 583    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764057271,2
    F,--117767878(+) ACCACA/TGTGAT 2 -- us2k11Minor allele frequency- T:0.05NA 120
    rs37532651,2
    C,H,--117767921(-) TTCTTC/TTTAAT 2 -- us2k15Minor allele frequency- T:0.01EA NS 1156
    rs745081821,2
    C,F,--117768505(+) TGTTAG/ATGAGT 2 -- us2k14Minor allele frequency- A:0.22WA CSA 123
    rs38200311,2
    H--117768614(-) CCTCCC/GTTGCT 2 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs66563601,2
    C,F,H,--117768967(+) GCTCCG/ATGTGT 2 -- us2k113Minor allele frequency- A:0.10NS EA NA WA 1376
    rs1132774991,2
    C,--117769502(+) GCCCAT/AGGGCT 2 -- us2k12Minor allele frequency- A:0.19CSA WA 120
    rs124022091,2
    C,H,--117769529(+) TCTTCT/CCCCAC 2 -- us2k1 trp32Minor allele frequency- C:0.08NA EA 124
    rs1118389971,2
    --117770361(+) CTTCCC/TGGCCA 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs795406371,2
    --117770777(+) ATAGAT/CTGAGT 2 -- int12Minor allele frequency- C:0.18CSA WA 120
    rs601053971,2
    C,--117771176(+) TTGCCT/ATCTTG 2 -- int13Minor allele frequency- A:0.12WA CSA 122

    HapMap Linkage Disequilibrium report for HAO2 (119911402 - 119936753 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HAO2
         1 CNV: 48018
    Locus Specific Mutation Databases (LSDB): HAO2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HAO2
    DNA2.0 Custom Variant and Variant Library Synthesis for HAO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HAO2 for disorders           About GeneDecksing

    OMIM gene information: 605176    OMIM disorders: --

    10 diseases for HAO2:    About MalaCards
    primary hyperoxaluria    sickle cell anemia    intrahepatic cholangiocarcinoma    nephrolithiasis
    adrenoleukodystrophy    cholangiocarcinoma    anemia    pneumonia
    tuberculosis    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: HAO2 (2 documents)

    Export disorders for HAO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HAO2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HAO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. (PubMed id 10777549)1, 2, 3, 9 Jones J.M.... Gould S.J. (2000)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    6. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51179 HGNC: 4810 AceView: HAO2 Ensembl:ENSG00000116882 euGenes: HUgn51179
    ECgene: HAO2 Kegg: 51179 H-InvDB: HAO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HAO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HAO2 gene:
    Search GeneIP for patents involving HAO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HAO2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAO2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAO2  
     OriGene Protein Over-expression Lysate for HAO2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HAO2   OriGene 3'-UTR Clone for HAO2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAO2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAO2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for HAO2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HAO2   OriGene Custom Protein Services for HAO2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HAO2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HAO2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAO2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAO2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAO2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAO2
     GenScript Custom Purified and Recombinant Proteins Services for HAO2 GenScript cDNA clones with any tag delivered in your preferred vector for HAO2
     GenScript Custom Assay Services for HAO2 GenScript Custom Superior Antibodies Services for HAO2
     GenScript Custom overexpressing Cell Line Services for HAO2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HAO2 promoter
     Search Chromatin IP Primers for HAO2
     RT2 qPCR Primer Assay in human, mouse, rat HAO2
     Search GNC Networks for HAO2
     SABiosciences PCR Arrays including human, mouse, rat HAO2
     Search Tocris compounds for HAO2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HAO2 antibodies
     HAO2 proteins
     HAO2 lysates
     Search for Antibodies for HAO2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HAO2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HAO2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HAO2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAO2
     SwitchGear 3'UTR luciferase reporter plasmids for HAO2
     SwitchGear Promoter luciferase reporter plasmids for HAO2
     Search ThermoFisher Antibodies for HAO2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAO2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HAO2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4