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Aliases & Descriptions for HAO2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 1.1.3.15 3 GIG16 1 , 2 HAOX2 1 , 2 , 3 , 5 OTTHUMP00000014486 2 OTTHUMP00000059527 2
Descriptions (S)-2-hydroxy-acid oxidase, peroxisomal 2 , 3 Long chain alpha-hydroxy acid oxidase 3 Long-chain L-2-hydroxy acid oxidase 2 , 3 glycolate oxidase 2 growth-inhibiting protein 16 2 hydroxyacid oxidase 2 2 hydroxyacid oxidase 2 (long chain) 2
Search outside databases for aliases for HAO2 genePrevious GC identifers: GC01P120358 GC01P118749 GC01P119058 GC01P119257
Summaries for HAO2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for HAO2 : This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ inencoded protein amino acid sequence, tissue expression and substrate preference. Subcellularlocation of the encoded protein is the peroxisome. Specifically, this gene is expressedpredominantly in liver and kidney and has the highest activity toward the substrate2-hydroxypalmitate. Two alternatively spliced variants encoding the same isoform have beendescribed. [provided by RefSeq] UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3 Function : Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that ofL-alpha-amino acids
Genomic Location for HAO2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the HAO2 gene Entrez Gene cytogenetic band: 1p13.3-p13.1 Ensembl cytogenetic band: 1p12 HGNC cytogenetic band: 1p13.3-p13.1 HAO2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P119623:
(about GC identifiers )
Start:
119,712,925 bp from pter
End:
119,738,274 bp from pter
Size:
25,350 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000001.9 NT_019273.18 Proteins for HAO2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
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Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
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R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3 (See
protein sequence )Recommended Name: Hydroxyacid oxidase 2 Size : 351 amino acids; 38839 Da
Cofactor : FMN
Subunit : Homotetramer or homooctamer (By similarity)
Subcellular location : Peroxisome
Secondary accessions : Q9UJS6
REFSEQ proteins (2 alternative transcripts):
NP_001005783.1 NP_057611.1 ENSEMBL proteins: ENSP00000358428 ENSP00000354314 ENSP00000316339 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: HAO2 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for HAO2: Assays for HAO2:
Protein
Domains/ Families for HAO2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9NYQ3 ProtoNet protein and cluster: Q9NYQ3
1 Blocks protein family : IPB000262 FMN-dependent alpha-hydroxy acid dehydrogenase UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3 Similarity : Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase familySimilarity : Contains 1 FMN hydroxy acid dehydrogenase domain
Gene Function for HAO2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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RNAi Products ,
Clones , and
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001005783 Applied Biosystems Silencer ® siRNAs for HAO2 Sigma-Aldrich siRNA for HAO2 Sigma-Aldrich shRNA for HAO2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001005783                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001005783                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001005783  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001005783 UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3 Function : Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that ofL-alpha-amino acids Catalytic activity : (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2)Enzyme Number (IUBMB): EC 1.1.3.15
4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for HAO2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for HAO2 (Your Favorite Gene powered by Ingenuity) 4 Interacting proteins for HAO2 (ENSP00000358428 3 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for HAO2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for HAO2
Transcripts for HAO2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001005783 Sigma-Aldrich siRNA for HAO2 Sigma-Aldrich shRNA for HAO2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001005783 NM_016527
REFSEQ mRNAs for HAO2 gene (2 alternative transcripts): NM_001005783.1 NM_016527.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001005783 NM_016527
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001005783                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001005783                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001005783  
Additional cDNA sequence: AF203975.1 AF231917.1 AK298289.1 AY513277.1 BC020863.1
6 DOTS entries : DT.40123369 DT.100784731 DT.100019080 DT.91711673 DT.100784732 DT.95246230
24/62 AceView cDNA sequences (see all 62
):AI733261 BE464431 BG564465 AW139221 AA969532 CB146914 CB162598 BG428569 AI373640 AI793285 CB148815 CB147318 BG428162 CB161619 BE048784 BG402318 CB148854 W78813 BG431374 CB146648 AA962446 AI636238 AI572851 CB121424
highest scoring ESTs for HAO2 :AW024657 AW025423 AA701282 AA703164 AA919149 AF203975 AF231917 AI271956 AI476213 AI795958
Unigene Cluster for HAO2: Hydroxyacid oxidase 2 (long chain) Hs.659767 [show with all ESTs ] Unigene Representative Sequence: AK298289 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for HAO2 ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c SP1 :                                 SP2 :       -                           SP3 :       -       -                     SP4 :                   -   -            
About this scheme ECgene alternative splicing isoforms for HAO2 3 Ensembl transcripts including schematic representations : ENST00000369420
ENST00000361035
ENST00000325945
Expression for HAO2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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HAO2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for HAO2 1 / 2 / 3
4 probe-sets matching HAO2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CCCTTCTTTGSOURCE GeneReport for Unigene cluster: Hs.659767 UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3 Tissue specificity : Liver and kidney
Orthologs for HAO2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for HAO2 gene from 5/14 species (see all 14
)
About this table Species with no ortholog for HAO2 ENSEMBL Gene Tree for HAO2 Paralogs for HAO2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for HAO2 gene HAO1 2
SNPs/Variants for HAO2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for HAO2 (up to first 250kb)
Disorders & Mutations for HAO2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 605176
Medical News for HAO2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for HAO2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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4 PubMed articles for HAO2 gene : Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. (PubMed id 10777549) 1, 2, 3, 4 Jones J.M.... Gould S.J. (2000) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing HAO2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing HAO2
(According to HUGE )
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Specialized Databases showing HAO2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for HAO2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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