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HAO2 Gene

protein-coding   GIFtS: 57
GCID: GC01P119913

Hydroxyacid Oxidase 2 (Long Chain)

  See HAO2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hydroxyacid Oxidase 2 (Long Chain)1 2     (S)-2-Hydroxy-Acid Oxidase, Peroxisomal2 3
Long-Chain L-2-Hydroxy Acid Oxidase1 2 3     (S)-2-Hydroxy-Acid Oxidase1
HAOX22 3 5     Growth-Inhibiting Protein 161
Glycolate Oxidase1 2     GIG162
Cell Growth-Inhibiting Gene 16 Protein2 3     Hydroxyacid Oxidase 22
Long Chain Alpha-Hydroxy Acid Oxidase2 3     EC 1.1.3.153

External Ids:    HGNC: 48101   Entrez Gene: 511792   Ensembl: ENSG000001168827   OMIM: 6051765   UniProtKB: Q9NYQ33   

Export aliases for HAO2 gene to outside databases

Previous GC identifers: GC01P120358 GC01P118749 GC01P119058 GC01P119257 GC01P119623 GC01P119712 GC01P117769


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAO2 Gene:
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein
amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is
the peroxisome. Specifically, this gene is expressed predominantly in liver and kidney and has the highest
activity toward the substrate 2-hydroxypalmitate. Two alternatively spliced variants encoding the same isoform
have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for HAO2 Gene:
HAO2 (hydroxyacid oxidase 2 (long chain)) is a protein-coding gene. Diseases associated with HAO2 include primary hyperoxaluria. GO annotations related to this gene include (S)-2-hydroxy-acid oxidase activity and receptor binding. An important paralog of this gene is HAO1.

UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3
Function: Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAO2 gene promoter:
         SRF   C/EBPbeta   PPAR-gamma1   AML1a   SRF (504 AA)   ARP-1   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAO2 promoter sequence
   Search Chromatin IP Primers for HAO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3-p13.1   Ensembl cytogenetic band:  1p12   HGNC cytogenetic band: 1p13.3-p13.1

HAO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAO2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P119913:  view genomic region     (about GC identifiers)

Start:
119,911,402 bp from pter      End:
119,936,753 bp from pter
Size:
25,352 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3 (See protein sequence)
Recommended Name: Hydroxyacid oxidase 2  
Size: 351 amino acids; 38839 Da
Cofactor: FMN
Subunit: Homotetramer or homooctamer (By similarity)
Secondary accessions: Q2TU86 Q9UJS6

Explore the universe of human proteins at neXtProt for HAO2: NX_Q9NYQ3

Explore proteomics data for HAO2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HAO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005783.1  NP_057611.1  

    ENSEMBL proteins: 
     ENSP00000393955   ENSP00000354314   ENSP00000316339  

    HAO2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR012133 Alpha-hydoxy_acid_DH_FMN
     IPR000262 FMN-dep_DH
     IPR008259 FMN_hydac_DH_AS

    Graphical View of Domain Structure for InterPro Entry Q9NYQ3

    ProtoNet protein and cluster: Q9NYQ3

    1 Blocks protein domain: IPB000262 FMN-dependent alpha-hydroxy acid dehydrogenase

    UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3
    Similarity: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family
    Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain


    Find genes that share domains with HAO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HAOX2_HUMAN, Q9NYQ3
    Function: Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids
    Catalytic activity: (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2)

         Enzyme Number (IUBMB): EC 1.1.3.151

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0003973(S)-2-hydroxy-acid oxidase activity IDA10777549
    GO:0005102receptor binding IPI--
    GO:0010181FMN binding IEA--
    GO:0015930glutamate synthase activity ----
         
    Find genes that share ontologies with HAO2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HAO2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAO2
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    GenScript: all cDNA clones in your preferred vector (see all 2): HAO2 (NM_016527)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HAOX2_HUMAN, Q9NYQ3: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    chloroplast2
    cytoskeleton2
    mitochondrion2
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome IDA10777549

    Find genes that share ontologies with HAO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HAO2 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Peroxisome
    Peroxisome
    3Glyoxylate and dicarboxylate metabolism
    Glyoxylate and dicarboxylate metabolism


    Find genes that share SuperPaths with HAO2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Kegg Pathways  (Kegg details for HAO2):
        Glyoxylate and dicarboxylate metabolism
    Metabolic pathways
    Peroxisome

        Pathway & Disease-focused RT2 Profiler PCR Array including HAO2: 
              Hepatotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HAO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HAO2 (ENSP000003163394) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRHPRENSP000003134324STRING: ENSP00000313432
    PGPENSP000003309184STRING: ENSP00000330918
    AGXT2ENSP000002314204STRING: ENSP00000231420
    DAOENSP000002284764STRING: ENSP00000228476
    TIMM50ENSP000003181154STRING: ENSP00000318115
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006537glutamate biosynthetic process ----
    GO:0018924mandelate metabolic process IEA--
    GO:0019395fatty acid oxidation IDA10777549
    GO:0051260protein homooligomerization IEA--
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with HAO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HAO2 (HAOX2)

    5 HMDB Compounds for HAO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Flavin MononucleotideFMN (see all 19)146-17-8--
    Glycolic acid2-Hydroxyacetate (see all 18)79-14-1--
    Glyoxylic acidFormylformate (see all 16)298-12-4--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    OxygenOxygen (see all 5)7782-44-7--

    1 DrugBank Compound for HAO2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Riboflavin Monophosphate-- 146-17-8target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HAO2 gene (2 alternative transcripts): 
    NM_001005783.1  NM_016527.2  

    Unigene Cluster for HAO2:

    Hydroxyacid oxidase 2 (long chain)
    Hs.659767  [show with all ESTs]
    Unigene Representative Sequence: AK298289
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457318 ENST00000361035(uc001ehq.1 uc001ehr.1) ENST00000325945
    ENST00000482991
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HAO2
      QuantiFast Probe-based Assays in human, mouse, rat HAO2

    Additional mRNA sequence: 

    AF203975.1 AF231917.1 AK298289.1 AY513277.1 BC020863.1 

    6 DOTS entries:

    DT.40123369  DT.100784731  DT.100019080  DT.91711673  DT.100784732  DT.95246230 

    Selected AceView cDNA sequences (see all 62):

    BE464431 AI733261 AA969532 AW139221 BG564465 CB147151 CB121424 AW001794 
    AI373640 BE048784 CB148854 CB161619 CB162598 CB147318 AI636238 AW771613 
    CB146914 AI793285 BG402318 BI765772 BG428162 CB147409 BI760034 BG428569 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HAO2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                                                                                                
    SP2:                    -                                                                           
    SP3:                    -                 -                                                         
    SP4:                                                        -     -                                 


    ECgene alternative splicing isoforms for HAO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HAO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTCTTTG
    HAO2 Expression
    About this image


    HAO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Testis (Reproductive System)
             Testis Interstitium
     
     Colon (Gastrointestinal Tract)
     
     Liver (Hepatobiliary System)
     
     Adrenal Gland (Endocrine System)
     
     Kidney (Urinary System)
    HAO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HAO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659767

    UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3
    Tissue specificity: Liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including HAO2: 
              Hepatotoxicity in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat HAO2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HAO2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hao21 , 5 hydroxyacid oxidase 21, 5 78.63(n)1
    71.23(a)1
      3 (42.90 cM)5
    561851  NM_019545.41  NP_062418.31 
     988745775 
    chicken
    (Gallus gallus)
    Aves HAO21 hydroxyacid oxidase 2 (long chain) 63.72(n)
    60.11(a)
      418311  XM_416535.4  XP_416535.4 
    lizard
    (Anolis carolinensis)
    Reptilia HAO26
    hydroxyacid oxidase 2 (long chain)
    56(a)
    1 ↔ 1
    GL343218.1(427549-444221)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985102 hypothetical protein LOC398510 72.59(n)    BC044114.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636902 hypothetical protein MGC63690 73.77(n)   393455  BC055205.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG180033 glycolate oxidase 46(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F41E6.53 glycolate oxidase 40(a)   V(8606190-8607675)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CYB21 CYB2 48.84(n)
    40.41(a)
      854950   NP_013658.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G141501 AT3G14150 51.9(n)
    48.98(a)
      820632  NM_001084683.1  NP_001078152.1 
    rice
    (Oryza sativa)
    Liliopsida AK068129.12   -- 69.25(n)    AK068129.1 


    ENSEMBL Gene Tree for HAO2 (if available)
    TreeFam Gene Tree for HAO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HAO2 gene
    HAO12  
    1 SIMAP similar gene for HAO2 using alignment to 3 protein entries:     HAOX2_HUMAN (see all proteins):
    HAO1

    Find genes that share paralogs with HAO2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HAO2 (see all 692)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs600694261,2
    C--119918728(+) CTCATC/TTGAGA 2 -- int10--------
    rs585169541,2
    C--119918827(+) AATACA/CGCCAT 2 -- int10--------
    rs1112953671,2
    F--119919014(+) GGCTTC/TTCAGG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs612759241,2
    C,F--119919474(+) AGACTG/ACACAA 2 -- int13Minor allele frequency- A:0.12WA CSA 122
    rs124043771,2
    H--119919510(+) tcttaA/Ggccta 2 -- int10--------
    rs600552141,2
    C,F--119919772(+) ATACAT/AAAAAC 2 -- int12Minor allele frequency- A:0.12WA 120
    rs729896871,2
    C,F--119920211(+) TAGTCC/AATTTT 2 -- int12Minor allele frequency- A:0.12WA 120
    rs604067211,2
    C--119920673(+) AAAAA-/ATGCAT 2 -- int10--------
    rs1930125571,2
    --119931777(+) TATATA/GTATAT 2 -- int10--------
    rs1846628441,2
    --119931778(+) ATATAC/TATATA 2 -- int10--------

    HapMap Linkage Disequilibrium report for HAO2 (119911402 - 119936753 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HAO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1759268CNV Insertion17803354
    esv34089CNV Loss18971310
    nsv2599CNV Loss18451855
    nsv524681CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): HAO2

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605176    OMIM disorders: --

    1 disease for HAO2:    
    About MalaCards
    primary hyperoxaluria

    2 diseases from the University of Copenhagen DISEASES database for HAO2:
    Primary hyperoxaluria     Nephrolithiasis

    Find genes that share disorders with HAO2           About GenesLikeMe

    Genetic Association Database (GAD): HAO2
    Human Genome Epidemiology (HuGE) Navigator: HAO2 (2 documents)

    Export disorders for HAO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HAO2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HAO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. (PubMed id 10777549)1, 2, 3, 9 Jones J.M.... Gould S.J. (J. Biol. Chem. 2000)
    2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)- Pex5p affinities. (PubMed id 20178365)1 Ghosh D. and Berg J.M. (J. Am. Chem. Soc. 2010)
    7. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51179 HGNC: 4810 AceView: HAO2 Ensembl:ENSG00000116882 euGenes: HUgn51179
    ECgene: HAO2 Kegg: 51179 H-InvDB: HAO2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HAO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HAO2 gene:
    Search GeneIP for patents involving HAO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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