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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HAO2 Gene

protein-coding   GIFtS: 58
GCID: GC01P119913

Hydroxyacid Oxidase 2 (Long Chain)

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hydroxyacid Oxidase 2 (Long Chain)1 2     (S)-2-Hydroxy-Acid Oxidase, Peroxisomal2 3
Long-Chain L-2-Hydroxy Acid Oxidase1 2 3     (S)-2-Hydroxy-Acid Oxidase1
HAOX22 3 5     Growth-Inhibiting Protein 161
Glycolate Oxidase1 2     GIG162
Cell Growth-Inhibiting Gene 16 Protein2 3     Hydroxyacid Oxidase 22
Long Chain Alpha-Hydroxy Acid Oxidase2 3     EC 1.1.3.153

External Ids:    HGNC: 48101   Entrez Gene: 511792   Ensembl: ENSG000001168827   OMIM: 6051765   UniProtKB: Q9NYQ33   

Export aliases for HAO2 gene to outside databases

Previous GC identifers: GC01P120358 GC01P118749 GC01P119058 GC01P119257 GC01P119623 GC01P119712 GC01P117769


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HAO2 Gene:
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein
amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is
the peroxisome. Specifically, this gene is expressed predominantly in liver and kidney and has the highest
activity toward the substrate 2-hydroxypalmitate. Two alternatively spliced variants encoding the same isoform
have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for HAO2 Gene: 
HAO2 (hydroxyacid oxidase 2 (long chain)) is a protein-coding gene. Diseases associated with HAO2 include primary hyperoxaluria, and sickle cell anemia, and among its related super-pathways are Metabolism. GO annotations related to this gene include (S)-2-hydroxy-acid oxidase activity and receptor binding. An important paralog of this gene is HAO1.

UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3
Function: Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HAO2 gene promoter:
         SRF   C/EBPbeta   PPAR-gamma1   AML1a   SRF (504 AA)   ARP-1   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HAO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3-p13.1   Ensembl cytogenetic band:  1p12   HGNC cytogenetic band: 1p13.3-p13.1

HAO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAO2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P119913:  view genomic region     (about GC identifiers)

Start:
119,911,402 bp from pter      End:
119,936,753 bp from pter
Size:
25,352 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3 (See protein sequence)
Recommended Name: Hydroxyacid oxidase 2  
Size: 351 amino acids; 38839 Da
Cofactor: FMN
Subunit: Homotetramer or homooctamer (By similarity)
Subcellular location: Peroxisome
Secondary accessions: Q2TU86 Q9UJS6

Explore the universe of human proteins at neXtProt for HAO2: NX_Q9NYQ3

Explore proteomics data for HAO2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYQ3

  • HAO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HAO2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005783.1  NP_057611.1  

    ENSEMBL proteins: 
     ENSP00000393955   ENSP00000354314   ENSP00000316339  

    Human Recombinant Protein Products for HAO2: 
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    Novus Biologicals HAO2 Protein
    Novus Biologicals HAO2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HAO2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome IDA10777549

    HAO2 for ontologies           About GeneDecksing



    HAO2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for HAO2 

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    Cloud-Clone Corp. CLIAs for HAO2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR012133 Alpha-hydoxy_acid_DH_FMN
     IPR000262 FMN-dep_DH
     IPR008259 FMN_hydac_DH_AS

    Graphical View of Domain Structure for InterPro Entry Q9NYQ3

    ProtoNet protein and cluster: Q9NYQ3

    1 Blocks protein domain: IPB000262 FMN-dependent alpha-hydroxy acid dehydrogenase

    UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3
    Similarity: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family
    Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain


    HAO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HAOX2_HUMAN, Q9NYQ3
    Function: Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids
    Catalytic activity: (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2)

         Enzyme Number (IUBMB): EC 1.1.3.151

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0003973(S)-2-hydroxy-acid oxidase activity IDA10777549
    GO:0005102receptor binding IPI--
    GO:0010181FMN binding IEA--
    GO:0015930glutamate synthase activity ----
         
    HAO2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HAO2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HAO2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HAO2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAO2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAO2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAO2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HAO2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Peroxisome
    Peroxisome
    3Glyoxylate and dicarboxylate metabolism
    Glyoxylate and dicarboxylate metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3         Kegg Pathways  (Kegg details for HAO2):
        Glyoxylate and dicarboxylate metabolism
    Metabolic pathways
    Peroxisome


    HAO2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HAO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for HAO2 (ENSP000003163394) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRHPRENSP000003134324STRING: ENSP00000313432
    PGPENSP000003309184STRING: ENSP00000330918
    AGXTENSP000003026204STRING: ENSP00000302620
    AGXT2ENSP000002314204STRING: ENSP00000231420
    DAOENSP000002284764STRING: ENSP00000228476
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006537glutamate biosynthetic process ----
    GO:0018924mandelate metabolic process IEA--
    GO:0019395fatty acid oxidation IDA10777549
    GO:0051260protein homooligomerization IEA--
    GO:0055114oxidation-reduction process ----

    HAO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HAO2 (HAOX2)

    5 HMDB Compounds for HAO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Flavin MononucleotideFMN (see all 19)146-17-8--
    Glycolic acid2-Hydroxyacetate (see all 18)79-14-1--
    Glyoxylic acidFormylformate (see all 16)298-12-4--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    OxygenOxygen (see all 5)7782-44-7--

    1 DrugBank Compound for HAO2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Riboflavin Monophosphate-- 146-17-8target--10592235

    Search CenterWatch for drugs/clinical trials and news about HAO2 / HAOX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HAO2 gene (2 alternative transcripts): 
    NM_001005783.1  NM_016527.2  

    Unigene Cluster for HAO2:

    Hydroxyacid oxidase 2 (long chain)
    Hs.659767  [show with all ESTs]
    Unigene Representative Sequence: AK298289
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457318 ENST00000361035(uc001ehq.1 uc001ehr.1) ENST00000325945
    ENST00000482991
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HAO2
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): HAO2 (NM_016527)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAO2
    Sirion Biotech Customized lentivirus for stable overexpression of HAO2 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAO2

    Additional mRNA sequence: 

    AF203975.1 AF231917.1 AK298289.1 AY513277.1 BC020863.1 

    6 DOTS entries:

    DT.40123369  DT.100784731  DT.100019080  DT.91711673  DT.100784732  DT.95246230 

    24/62 AceView cDNA sequences (see all 62):

    AW139221 BE464431 AA969532 AI733261 BG564465 AW299779 BG674888 AI636238 
    AI373640 CB146648 CB147409 BG431374 AW613512 BG402318 BG428569 CB146686 
    AA962446 BI760034 AW242782 CB148854 CB162598 CB148815 BG428162 CB161619 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HAO2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                                                                                                
    SP2:                    -                                                                           
    SP3:                    -                 -                                                         
    SP4:                                                        -     -                                 


    ECgene alternative splicing isoforms for HAO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HAO2 expression in normal human tissues (normalized intensities)      HAO2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTCTTTG
    HAO2 Expression
    About this image


    HAO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Testis (Reproductive System)
             Testis Interstitium
     
     Neural Tube (Nervous System)
             Prosencephalon
     
     Liver (Hepatobiliary System)
     
     Adrenal Gland (Endocrine System)
     
     Kidney (Urinary System)

    See HAO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HAO2

    SOURCE GeneReport for Unigene cluster: Hs.659767

    UniProtKB/Swiss-Prot: HAOX2_HUMAN, Q9NYQ3
    Tissue specificity: Liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including HAO2: 
              Hepatotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HAO2 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hao21 , 5 hydroxyacid oxidase 21, 5 78.63(n)1
    71.23(a)1
      3 (42.90 cM)5
    561851  NM_019545.41  NP_062418.31 
     988745775 
    chicken
    (Gallus gallus)
    Aves HAO21 hydroxyacid oxidase 2 (long chain) 63.63(n)
    60.11(a)
      418311  XM_416535.3  XP_416535.3 
    lizard
    (Anolis carolinensis)
    Reptilia HAO26
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL343218.1(427549-444221)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985102 hypothetical protein LOC398510 72.59(n)    BC044114.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636902 hypothetical protein MGC63690 73.77(n)   393455  BC055205.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG180033 glycolate oxidase 46(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F41E6.53 glycolate oxidase 40(a)   V(8606190-8607675)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CYB21 Cyb2p 48.74(n)
    40.41(a)
      854950   NP_013658.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G141501 Aldolase-type TIM barrel family protein 51.9(n)
    48.98(a)
      820632  NM_001084683.1  NP_001078152.1 
    rice
    (Oryza sativa)
    Liliopsida AK068129.12   -- 69.25(n)    AK068129.1 


    ENSEMBL Gene Tree for HAO2 (if available)
    TreeFam Gene Tree for HAO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HAO2 gene
    HAO12  
    1 SIMAP similar gene for HAO2 using alignment to 3 protein entries:     HAOX2_HUMAN (see all proteins):
    HAO1

    HAO2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/692 SNPs in HAO2 are shown (see all 692)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs600694261,2
    C--119918728(+) CTCATC/TTGAGA 2 -- int10--------
    rs585169541,2
    C--119918827(+) AATACA/CGCCAT 2 -- int10--------
    rs1112953671,2
    F--119919014(+) GGCTTC/TTCAGG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs612759241,2
    C,F--119919474(+) AGACTG/ACACAA 2 -- int13Minor allele frequency- A:0.12WA CSA 122
    rs124043771,2
    H--119919510(+) tcttaA/Ggccta 2 -- int10--------
    rs600552141,2
    C,F--119919772(+) ATACAT/AAAAAC 2 -- int12Minor allele frequency- A:0.12WA 120
    rs729896871,2
    C,F--119920211(+) TAGTCC/AATTTT 2 -- int12Minor allele frequency- A:0.12WA 120
    rs604067211,2
    C--119920673(+) AAAAA-/ATGCAT 2 -- int10--------
    rs1930125571,2
    --119931777(+) TATATA/GTATAT 2 -- int10--------
    rs1846628441,2
    --119931778(+) ATATAC/TATATA 2 -- int10--------

    HapMap Linkage Disequilibrium report for HAO2 (119911402 - 119936753 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HAO2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1759268CNV Insertion17803354
    esv34089CNV Loss18971310
    nsv2599CNV Loss18451855
    nsv524681CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): HAO2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605176    OMIM disorders: --

    9 diseases for HAO2:    About MalaCards
    primary hyperoxaluria    sickle cell anemia    nephrolithiasis    adrenoleukodystrophy
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    pneumonia    anemia
    tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for HAO2:
    Primary hyperoxaluria     Nephrolithiasis

    HAO2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HAO2
    Human Genome Epidemiology (HuGE) Navigator: HAO2 (2 documents)

    Export disorders for HAO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HAO2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HAO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. (PubMed id 10777549)1, 2, 3, 9 Jones J.M.... Gould S.J. (2000)
    2. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A proteome-wide perspective on peroxisome targeting s ignal 1(PTS1)-Pex5p affinities. (PubMed id 20178365)1 Ghosh D. and Berg J.M. (2010)
    7. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51179 HGNC: 4810 AceView: HAO2 Ensembl:ENSG00000116882 euGenes: HUgn51179
    ECgene: HAO2 Kegg: 51179 H-InvDB: HAO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HAO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HAO2 gene:
    Search GeneIP for patents involving HAO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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