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Aliases for HAO2 Gene

Aliases for HAO2 Gene

  • Hydroxyacid Oxidase 2 2 3
  • Long-Chain L-2-Hydroxy Acid Oxidase 2 3 4
  • Hydroxyacid Oxidase 2 (Long Chain) 2 3 5
  • (S)-2-Hydroxy-Acid Oxidase, Peroxisomal 3 4
  • Cell Growth-Inhibiting Gene 16 Protein 3 4
  • Long Chain Alpha-Hydroxy Acid Oxidase 3 4
  • Glycolate Oxidase 2 3
  • HAOX2 3 4
  • Growth-Inhibiting Protein 16 2
  • (S)-2-Hydroxy-Acid Oxidase 2
  • EC 1.1.3.15 4
  • GIG16 3

External Ids for HAO2 Gene

Previous GeneCards Identifiers for HAO2 Gene

  • GC01P120358
  • GC01P118749
  • GC01P119058
  • GC01P119257
  • GC01P119623
  • GC01P119712
  • GC01P119913
  • GC01P117769

Summaries for HAO2 Gene

Entrez Gene Summary for HAO2 Gene

  • This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for HAO2 Gene

HAO2 (Hydroxyacid Oxidase 2) is a Protein Coding gene. Among its related pathways are Carbon metabolism and Glyoxylate and dicarboxylate metabolism. GO annotations related to this gene include receptor binding and FMN binding. An important paralog of this gene is HAO1.

UniProtKB/Swiss-Prot for HAO2 Gene

  • Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAO2 Gene

Genomics for HAO2 Gene

Regulatory Elements for HAO2 Gene

Enhancers for HAO2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HAO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HAO2 Gene

Chromosome:
1
Start:
119,368,776 bp from pter
End:
119,394,130 bp from pter
Size:
25,355 bases
Orientation:
Plus strand

Genomic View for HAO2 Gene

Genes around HAO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAO2 Gene

Proteins for HAO2 Gene

  • Protein details for HAO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYQ3-HAOX2_HUMAN
    Recommended name:
    Hydroxyacid oxidase 2
    Protein Accession:
    Q9NYQ3
    Secondary Accessions:
    • Q2TU86
    • Q5QP00
    • Q9UJS6

    Protein attributes for HAO2 Gene

    Size:
    351 amino acids
    Molecular mass:
    38839 Da
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    • Homotetramer or homooctamer.

    Alternative splice isoforms for HAO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAO2 Gene

Proteomics data for HAO2 Gene at MOPED

Post-translational modifications for HAO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HAO2 Gene

No data available for DME Specific Peptides for HAO2 Gene

Domains & Families for HAO2 Gene

Suggested Antigen Peptide Sequences for HAO2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYQ3

UniProtKB/Swiss-Prot:

HAOX2_HUMAN :
  • Contains 1 FMN hydroxy acid dehydrogenase domain.
  • Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
Domain:
  • Contains 1 FMN hydroxy acid dehydrogenase domain.
Family:
  • Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
genes like me logo Genes that share domains with HAO2: view

No data available for Gene Families for HAO2 Gene

Function for HAO2 Gene

Molecular function for HAO2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.

Enzyme Numbers (IUBMB) for HAO2 Gene

Gene Ontology (GO) - Molecular Function for HAO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0016491 oxidoreductase activity IEA --
GO:0052853 long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity IDA,TAS --
genes like me logo Genes that share ontologies with HAO2: view
genes like me logo Genes that share phenotypes with HAO2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HAO2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HAO2 Gene

Localization for HAO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAO2 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAO2 Gene COMPARTMENTS Subcellular localization image for HAO2 gene
Compartment Confidence
extracellular 5
peroxisome 5
cytoskeleton 2
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HAO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HAO2: view

Pathways & Interactions for HAO2 Gene

genes like me logo Genes that share pathways with HAO2: view

Interacting Proteins for HAO2 Gene

Gene Ontology (GO) - Biological Process for HAO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019395 fatty acid oxidation IDA 10777549
genes like me logo Genes that share ontologies with HAO2: view

No data available for SIGNOR curated interactions for HAO2 Gene

Drugs & Compounds for HAO2 Gene

(4) Drugs for HAO2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flavin Mononucleotide Experimental Pharma Target 6
Glycolic acid Experimental Pharma 13
Glyoxylic acid Experimental Pharma 0
Hydrogen peroxide Pharma 47

(1) Additional Compounds for HAO2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with HAO2: view

Transcripts for HAO2 Gene

Unigene Clusters for HAO2 Gene

Hydroxyacid oxidase 2 (long chain):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1:
SP2: -
SP3: - -
SP4: - -

Relevant External Links for HAO2 Gene

GeneLoc Exon Structure for
HAO2
ECgene alternative splicing isoforms for
HAO2

Expression for HAO2 Gene

mRNA expression in normal human tissues for HAO2 Gene

mRNA differential expression in normal tissues according to GTEx for HAO2 Gene

This gene is overexpressed in Liver (x37.8) and Kidney - Cortex (x13.1).

Protein differential expression in normal tissues from HIPED for HAO2 Gene

This gene is overexpressed in Lung (28.0), Kidney (24.9), and Liver (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HAO2 Gene



SOURCE GeneReport for Unigene cluster for HAO2 Gene Hs.659767

mRNA Expression by UniProt/SwissProt for HAO2 Gene

Q9NYQ3-HAOX2_HUMAN
Tissue specificity: Liver and kidney.
genes like me logo Genes that share expression patterns with HAO2: view

Protein tissue co-expression partners for HAO2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HAO2 Gene

Orthologs for HAO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HAO2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HAO2 35
  • 82.72 (n)
  • 81.77 (a)
HAO2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAO2 35
  • 85.75 (n)
  • 82.34 (a)
HAO2 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hao2 35
  • 78.63 (n)
  • 71.23 (a)
Hao2 16
Hao2 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HAO2 35
  • 99.72 (n)
  • 99.71 (a)
HAO2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hao2 35
  • 79.87 (n)
  • 74.07 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia HAO2 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves HAO2 35
  • 63.72 (n)
  • 60.11 (a)
HAO2 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HAO2 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hao2 35
  • 63.72 (n)
  • 63.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398510 35
zebrafish
(Danio rerio)
Actinopterygii hao2 35
  • 63.31 (n)
  • 62.36 (a)
zgc63690 35
hao2 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.904 35
fruit fly
(Drosophila melanogaster)
Insecta CG18003 37
  • 46 (a)
CG18003 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F41E6.5 37
  • 40 (a)
F41E6.5 36
  • 39 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02640g 35
  • 50.87 (n)
  • 41.04 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYB2 35
  • 48.84 (n)
  • 40.41 (a)
CYB2 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G14150 35
  • 51.9 (n)
  • 48.98 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2092 35
rice
(Oryza sativa)
Liliopsida Os07g0616500 35
  • 51.17 (n)
  • 47.37 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08272 35
  • 49.85 (n)
  • 39.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7836 36
  • 52 (a)
ManyToMany
Species with no ortholog for HAO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HAO2 Gene

ENSEMBL:
Gene Tree for HAO2 (if available)
TreeFam:
Gene Tree for HAO2 (if available)

Paralogs for HAO2 Gene

Paralogs for HAO2 Gene

(1) SIMAP similar genes for HAO2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HAO2: view

Variants for HAO2 Gene

Sequence variations from dbSNP and Humsavar for HAO2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34638261 - 119,381,128(+) CGCGA(A/C/G)AGCAG reference, missense
rs6661625 - 119,386,721(+) TCATC(A/C)TGAAA intron-variant, reference, missense
rs1417604 -- 119,385,760(-) CACAG(C/T)TGCCC intron-variant, utr-variant-3-prime
rs1341007 -- 119,382,780(-) GTTCA(A/G)TTGGC intron-variant
rs2298027 -- 119,382,841(+) AGGGG(A/G)GTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAO2 Gene

Variant ID Type Subtype PubMed ID
nsv524681 CNV Gain 19592680
esv34089 CNV Loss 18971310
esv1759268 CNV Insertion 17803354
nsv2599 CNV Loss 18451855

Variation tolerance for HAO2 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HAO2 Gene

Disorders for HAO2 Gene

Relevant External Links for HAO2

Genetic Association Database (GAD)
HAO2
Human Genome Epidemiology (HuGE) Navigator
HAO2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAO2

No disorders were found for HAO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAO2 Gene

Publications for HAO2 Gene

  1. Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. (PMID: 10777549) Jones J.M. … Gould S.J. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase. (PMID: 22658862) Barawkar D.A. … Singh S.B. (Bioorg. Med. Chem. Lett. 2012) 3

Products for HAO2 Gene

Sources for HAO2 Gene

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