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Aliases & Descriptions for HAO1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 1.1.3.15 3 | | GOX 1, 2, 3 | | GOX1 2, 3, 5 | | HAOX1 2, 3 | | MGC142225 2 | | MGC142227 2 | | OTTHUMP00000030231 2 |
| | | Descriptions |
|---|
| (S)-2-hydroxy-acid oxidase 2 | | Glycolate oxidase 2, 3 | | hydroxyacid oxidase (glycolate oxidase) 1 2 | | hydroxyacid oxidase 1 2 |
|
| | Search outside databases for aliases for HAO1 genePrevious GC identifers: GC20M007851 GC20M007858 |
Summaries for HAO1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HAO1: This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq] UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8Function: Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids |
Genomic Location for HAO1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HAO1 gene 
Entrez Gene cytogenetic band: 20p12 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20p12HAO1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M007811:
(about GC identifiers)
Start:
|
7,811,631 bp from pter |
End:
|
7,869,093 bp from pter |
Size:
|
57,463 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000020.9 NT_011387.8
| Proteins for HAO1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8 (See
protein sequence)Recommended Name: Hydroxyacid oxidase 1 Size: 370 amino acids; 40924 Da
Cofactor: FMN
Subcellular location: Peroxisome
PDB structures from and Proteopedia :2NZL (3D)
 2RDT (3D)
 2RDU (3D)
 2RDW (3D)
 
Secondary accessions: Q14CQ0 Q9UPZ0 Q9Y3I7Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060015.1
ENSEMBL proteins: ENSP00000368066
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: HAO1 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for HAO1: Assays for HAO1: | Protein
Domains/ Families for HAO1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UJM8
ProtoNet protein and cluster: Q9UJM8 1 Blocks protein family: IPB000262 FMN-dependent alpha-hydroxy acid dehydrogenase
UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8Similarity: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase familySimilarity: Contains 1 FMN hydroxy acid dehydrogenase domain | Gene Function for HAO1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017545
Applied Biosystems Silencer® siRNAs for HAO1
Sigma-Aldrich siRNA and siRNA Panels for HAO1  Sigma-Aldrich shRNA for HAO1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017545                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017545                                  untagged cDNA clone in CMV expression vector: NM_017545 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_017545
UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8Function: Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acidsCatalytic activity: (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2)Enzyme Number (IUBMB): EC 1.1.3.15 Genatlas biochemistry entry for HAO1:hydroxyacid oxidase 1,glycolate oxidase4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for HAO1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for HAO1 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8Pathway: Organic acid metabolism; glycolic acid degradation; 3-phospho-D-glyceric acid from glycolic acid: step 1/4 5/6 Interacting proteins for HAO1 (ENSP000003680663) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for HAO1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for HAO1 10/34 Novoseek chemical compound relationships for HAO1 gene (see all 34
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nafion |
82.60 |
9 |
16275055 (1), 15967398 (1), 19071561 (1), 16219381 (1) (see all 7) |
| glucose |
81.09 |
395 |
17365439 (5), 16870421 (3), 19269439 (3), 17113278 (3) (see all 99) |
| poly(dimethyl diallyl ammonium chloride) |
79.80 |
7 |
18180205 (2), 16430853 (1), 16207046 (1), 17314038 (1) |
| agcl |
78.41 |
1 |
15649080 (1) |
| polyvinylimidazole |
77.44 |
2 |
14516076 (1), 15794489 (1) |
| fadh2 |
76.98 |
8 |
15461503 (2), 12622383 (1), 15970532 (1), 15649080 (1) |
| ferrocenemethanol |
76.64 |
1 |
16471810 (1) |
| ethylene glycol diglycidyl ether |
73.15 |
2 |
7733469 (1) |
| platinum |
70.53 |
16 |
9491756 (1), 19112013 (1), 15284922 (1), 15283600 (1) (see all 11) |
| ferrocene |
66.48 |
15 |
8797376 (2), 12298004 (2), 11411531 (2), 7810897 (2) (see all 7) |
About this table
|
Transcripts for HAO1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017545
Sigma-Aldrich siRNA and siRNA Panels for HAO1  Sigma-Aldrich shRNA for HAO1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_017545 REFSEQ mRNAs for HAO1 gene: NM_017545.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_017545               OriGene GFP tagged cDNA clone in CMV expression vector: NM_017545                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017545                                  untagged cDNA clone in CMV expression vector: NM_017545  Additional cDNA sequence: AB024079.1 AF231916.1 AF244134.1 AK289423.1 AK308963.1 AK313839.1 AL121739.1 BC113665.1 BC113667.1 2 DOTS entries: DT.105299 DT.99965022 24/28 AceView cDNA sequences (see all 28
):NM_017545 CB161531 AB024079 AL121739 AI913732 C20914 AF244134 BG656034 AF231916 AV646933 BG568066 H70488 AV647445 CB163751 BX094967 AW772047 AV682372 AL449681 H69642 BG656337 T72614 T97636 T97637 AL449669
highest scoring ESTs for HAO1:AB024079 AF231916 AF244134 AI913732 AL121739 AL449668 AL449669 AL449681 T58830 T64673 Unigene Cluster for HAO1: Hydroxyacid oxidase (glycolate oxidase) 1 Hs.193640 [show with all ESTs]Unigene Representative Sequence: AL121739
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000378789
|
Expression for HAO1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HAO1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HAO1
1 / 2 / 3 4 probe-sets matching HAO1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCTTTAAAAC
SOURCE GeneReport for Unigene cluster: Hs.193640 UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8Tissue specificity: Liver |
Orthologs for HAO1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HAO1 gene from 5/20 species (see all 20
)
About this table Species with no ortholog for HAO1
ENSEMBL Gene Tree for HAO1 | Paralogs for HAO1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for HAO1 gene
- HAO22
|
SNPs/Variants for HAO1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HAO1 (up to first 250kb)
|
Disorders & Mutations for HAO1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605023
1 Novoseek disease relationship for HAO1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hypoglycemia |
0.00 |
1 |
17365439 (1) |
About this table
|
Medical News for HAO1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HAO1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/180 PubMed articles for HAO1 gene (see all 180
):- Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. (PubMed id 10777549)1, 3, 4 Jones J.M.... Gould S.J. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)3, 4 Deloukas P....Rogers J. (2001)
- Identification and expression of a cDNA for human glycolate oxidase. (PubMed id 10978532)3, 4 Williams E.L.... Rumsby G. (2000)
- Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA. (PubMed id 9891009)2, 3 Kohler S.A....Kuhn L.C. (1999)
- Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design. (PubMed id 18215067)3 Murray M.S....Lowther W.T. (2008)
- Purification and characterization of recombinant human liver glycolate oxidase. (PubMed id 17669354)3 Vignaud C....Lederer F. (2007)
- Direct interaction between alpha-actinin and hepatitis C virus NS5B. (PubMed id 14623081)3 Lan S....Yuan Z. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Immobilization and bioactivity of glucose oxidase in hydrogel microspheres formulated by an emulsification-internal gelation-adsorption-polyelectrolyte coating method. (PubMed id 17398046)1 Liu Q....Wu X.Y. (2007)
|
Search for HAO1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HAO1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HAO1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HAO1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HAO1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HAO1:

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Incremental update: 13 Oct 2009
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