Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HAO1 Gene

protein-coding   GIFtS: 61
GCID: GC20M007863

Hydroxyacid Oxidase (Glycolate Oxidase) 1


(Previous symbol: GOX1)
  See HAO1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Hydroxyacid Oxidase (Glycolate Oxidase) 11 2     HAOX12 3
GOX11 2 3 5     (S)-2-Hydroxy-Acid Oxidase2
Glycolate Oxidase2 3     Hydroxyacid Oxidase 12
GOX2 3     EC 1.1.3.153

External Ids:    HGNC: 48091   Entrez Gene: 543632   Ensembl: ENSG000001013237   OMIM: 6050235   UniProtKB: Q9UJM83   

Export aliases for HAO1 gene to outside databases

Previous GC identifers: GC20M007851 GC20M007858 GC20M007811


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HAO1 Gene:
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein
amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is
the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is
most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The
transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a
multiple near-consensus upstream polyadenylation site. (provided by RefSeq, Jul 2008)

GeneCards Summary for HAO1 Gene:
HAO1 (hydroxyacid oxidase (glycolate oxidase) 1) is a protein-coding gene. Diseases associated with HAO1 include primary hyperoxaluria. GO annotations related to this gene include (S)-2-hydroxy-acid oxidase activity and receptor binding. An important paralog of this gene is HAO2.

UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8
Function: Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active
on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAO1 gene promoter:
         GR   SRF (504 AA)   GR-beta   C/EBPalpha   PPAR-alpha   POU2F1   POU2F1b   POU2F1a   POU2F1c   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAO1 promoter sequence
   Search Chromatin IP Primers for HAO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p12

HAO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAO1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M007863:  view genomic region     (about GC identifiers)

Start:
7,863,628 bp from pter      End:
7,921,121 bp from pter
Size:
57,494 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8 (See protein sequence)
Recommended Name: Hydroxyacid oxidase 1  
Size: 370 amino acids; 40924 Da
Cofactor: FMN
5 PDB 3D structures from and Proteopedia for HAO1:
2NZL (3D)        2RDT (3D)        2RDU (3D)        2RDW (3D)        2W0U (3D)    
Secondary accessions: Q14CQ0 Q9UPZ0 Q9Y3I7

Explore the universe of human proteins at neXtProt for HAO1: NX_Q9UJM8

Explore proteomics data for HAO1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HAO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060015.1  
    ENSEMBL proteins: 
     ENSP00000368066  
    Reactome Protein details: Q9UJM8

    HAO1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HAO1 (Hydroxyacid Oxidase-1/HAO-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for HAO1
    OriGene Protein Over-expression Lysate for HAO1
    OriGene MassSpec for HAO1
    OriGene Custom Protein Services for HAO1
    GenScript Custom Purified and Recombinant Proteins Services for HAO1
    Novus Biologicals HAO1 Proteins
    Novus Biologicals HAO1 Lysates
    Sino Biological Recombinant Protein for HAO1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HAO1
    Cloud-Clone Corp. Proteins for HAO1

     
    Search eBioscience for Proteins for HAO1 

     
    antibodies-online proteins for HAO1 (15 products) 

     
    antibodies-online peptides for HAO1

    HAO1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HAO1 (Hydroxyacid Oxidase-1/HAO-1)
    OriGene Antibodies for HAO1
    OriGene Custom Antibody Services for HAO1
    Novus Biologicals HAO1 Antibodies
    Abcam antibodies for HAO1
    Cloud-Clone Corp. Antibodies for HAO1
    Search ThermoFisher Antibodies for HAO1
    antibodies-online antibodies for HAO1 (41 products) 

    HAO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HAO1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HAO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HAO1
    Cloud-Clone Corp. CLIAs for HAO1
    Search eBioscience for ELISAs for HAO1 
    antibodies-online kits for HAO1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR012133 Alpha-hydoxy_acid_DH_FMN
     IPR000262 FMN-dep_DH
     IPR008259 FMN_hydac_DH_AS

    Graphical View of Domain Structure for InterPro Entry Q9UJM8

    ProtoNet protein and cluster: Q9UJM8

    1 Blocks protein domain: IPB000262 FMN-dependent alpha-hydroxy acid dehydrogenase

    UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8
    Similarity: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family
    Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain


    Find genes that share domains with HAO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HAOX1_HUMAN, Q9UJM8
    Function: Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active
    on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate
    Catalytic activity: (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2)
    Biophysicochemical properties: Kinetic parameters: KM=141 uM for glycolate; KM=40 uM for 2-hydroxy octanoate;
    KM=2200 uM for glyoxylate;

         Genatlas biochemistry entry for HAO1:
    hydroxyacid oxidase 1,glycolate oxidase

         Enzyme Number (IUBMB): EC 1.1.3.151

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003973(S)-2-hydroxy-acid oxidase activity IDA10777549
    GO:0005102receptor binding IPI--
    GO:0008891glycolate oxidase activity TAS--
    GO:0010181FMN binding IDA18215067
    GO:0015930glutamate synthase activity ----
         
    Find genes that share ontologies with HAO1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HAO1:
     Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HAO1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HAO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HAO1 (see all 23):
    hsa-miR-596 hsa-miR-4307 hsa-miR-1197 hsa-miR-128 hsa-miR-132 hsa-miR-1297 hsa-miR-374c hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidHAO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HAO1
    Predesigned siRNA for gene silencing in human, mouse, rat HAO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HAO1

    Clone
    Products:
         
    OriGene clones in human, mouse for HAO1 (see all 6)
    OriGene ORF clones in mouse, rat for HAO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HAO1 (NM_017545)
    Sino Biological Human cDNA Clone for HAO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAO1
    Addgene plasmids for HAO1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HAO1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HAO1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HAOX1_HUMAN, Q9UJM8: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    chloroplast2
    cytosol2
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777peroxisome IDA10777549
    GO:0005782peroxisomal matrix TAS--

    Find genes that share ontologies with HAO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HAO1 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Glyoxylate metabolism0.00
    3Peroxisome
    Peroxisome
    4Glyoxylate and dicarboxylate metabolism
    Glyoxylate and dicarboxylate metabolism


    Find genes that share SuperPaths with HAO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for HAO1
        Glyoxylate metabolism


    3 Kegg Pathways  (Kegg details for HAO1):
        Glyoxylate and dicarboxylate metabolism
    Metabolic pathways
    Peroxisome

    UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8
    Pathway: Organic acid metabolism; glycolate degradation; 3-phospho-D-glycerate from glycolate: step 1/4

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HAO1
    Interactions:

        Search GeneGlobe Interaction Network for HAO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HAO1 (Q9UJM83 ENSP000003680664) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096150P622693I2D: score=2 
    ENSG00000223367P622693I2D: score=2 
    ENSG00000226225P622693I2D: score=2 
    ENSG00000235650P622693I2D: score=2 
    RPS18P622693I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001561fatty acid alpha-oxidation IDA18215067
    GO:0006537glutamate biosynthetic process ----
    GO:0006979response to oxidative stress IEA--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with HAO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HAO1 (HAOX1)

    5 HMDB Compounds for HAO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Flavin MononucleotideFMN (see all 19)146-17-8--
    Glycolic acid2-Hydroxyacetate (see all 18)79-14-1--
    Glyoxylic acidFormylformate (see all 16)298-12-4--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    OxygenOxygen (see all 5)7782-44-7--

    10 DrugBank Compounds for HAO1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzoylformic Acid-- 611-73-4target--17139284 17016423 10592235
    Heme-- --target--17139284 17016423 10592235
    N-Sulfo-Flavin Mononucleotide-- --target--17139284 17016423 10592235
    Riboflavin Monophosphate-- 146-17-8target--17139284 17016423 10592235
    (2S)-2-HYDROXYOCTANOIC ACID-- --target--10592235
    3-(INDOL-3-YL) LACTATE-- --target--10592235
    3-Decyl-2,5-Dioxo-4-Hydroxy-3-Pyrroline-- --target--10592235
    3-Phenylpyruvic Acid-- --target--10592235
    4-Carboxy-5-(1-Pentyl)Hexylsulfanyl-1,2,3-Triazole-- --target--10592235
    5-(dodecylthio)-1H-1,2,3-triazole-4-carboxylic acid-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for HAO1 gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 82.3 475 17365439 (5), 16870421 (3), 19505077 (3), 19269439 (3) (see all 99)
    nafion 82.2 9 16275055 (1), 15967398 (1), 19071561 (1), 16219381 (1) (see all 7)
    agcl 78.1 1 15649080 (1)
    fadh2 77.4 8 15461503 (2), 12622383 (1), 15970532 (1), 15649080 (1)
    poly(dimethyl diallyl ammonium chloride) 77.1 7 18180205 (2), 16430853 (1), 16207046 (1), 17314038 (1)
    poly(1-vinylimidazole) 75.5 2 14516076 (1), 15794489 (1)
    ferrocenemethanol 73.6 1 16471810 (1)
    platinum 71.1 20 9491756 (1), 19112013 (1), 20388977 (1), 15284922 (1) (see all 13)
    ethylene glycol diglycidyl ether 70.9 2 7733469 (1)
    ferrocene 70 19 19505077 (2), 8797376 (2), 12298004 (2), 11411531 (2) (see all 10)



    Find genes that share compounds with HAO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HAO1 gene: 
    NM_017545.2  

    Unigene Cluster for HAO1:

    Hydroxyacid oxidase (glycolate oxidase) 1
    Hs.193640  [show with all ESTs]
    Unigene Representative Sequence: AL121739
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000378789(uc002wmw.1 uc010gbu.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HAO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HAO1 (see all 23):
    hsa-miR-596 hsa-miR-4307 hsa-miR-1197 hsa-miR-128 hsa-miR-132 hsa-miR-1297 hsa-miR-374c hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidHAO1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HAO1
    Predesigned siRNA for gene silencing in human, mouse, rat HAO1
    Clone
    Products:
         
    OriGene clones in human, mouse for HAO1 (see all 6)
    OriGene ORF clones in mouse, rat for HAO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HAO1 (NM_017545)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAO1
    Addgene plasmids for HAO1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HAO1
    OriGene qSTAR qPCR primer pairs in human, mouse for HAO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAO1
      QuantiTect SYBR Green Assays in human, mouse, rat HAO1
      QuantiFast Probe-based Assays in human, mouse, rat HAO1

    Additional mRNA sequence: 

    AB024079.1 AF231916.1 AF244134.1 AK289423.1 AK308963.1 AK313839.1 AL121739.1 BC113665.1 
    BC113667.1 

    2 DOTS entries:

    DT.105299  DT.99965022 

    Selected AceView cDNA sequences (see all 28):

    C20914 AL121739 BG656034 AB024079 CB161531 AI913732 AF244134 NM_017545 
    AV646933 AW772047 H70488 CB163751 AV647445 H69642 AF231916 BX094967 
    BG568066 AL449681 AV682372 BG656337 T72614 T74667 T97636 T97637 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HAO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTAAAAC
    HAO1 Expression
    About this image

    HAO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HAO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.193640

    UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8
    Tissue specificity: Liver

        Custom PCR Arrays for HAO1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HAO1
    OriGene qSTAR qPCR primer pairs in human, mouse for HAO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAO1
    QuantiTect SYBR Green Assays in human, mouse, rat HAO1
    QuantiFast Probe-based Assays in human, mouse, rat HAO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HAO1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hao11 , 5 hydroxyacid oxidase 1, liver1, 5 87.12(n)1
    89.46(a)1
      2 (65.65 cM)5
    151121  NM_010403.21  NP_034533.11 
     1344973615 
    chicken
    (Gallus gallus)
    Aves HAO11 hydroxyacid oxidase (glycolate oxidase) 1 71.64(n)
    73.98(a)
      416728  NM_001199442.1  NP_001186371.1 
    lizard
    (Anolis carolinensis)
    Reptilia HAO16
    hydroxyacid oxidase (glycolate oxidase) 1
    77(a)
    1 ↔ 1
    1(135884049-135913779)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.35342 Xenopus laevis transcribed sequence with weak similarity more 73.14(n)    BJ036588.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.21322 Danio rerio cDNA clone IMAGE5914839, partial cds 72.95(n)    BC055638.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG180031 , 3 glycolate oxidase3
    CG180031
    48(a)3
    54.08(n)1
    48.73(a)1
      37717791  NM_001032231.21  NP_001027402.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F41E6.51 , 3 glycolate oxidase3
    F41E6.51
    46(a)3
    51.81(n)1
    46.86(a)1
      V(8606190-8607675)3
    1792411  NM_001129469.21  NP_001122941.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CYB2(YML054C)4 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), more   --   13(167308-165533) 854950  NP_013658.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G183601 AT4G18360 55.97(n)
    57.67(a)
      827563  NM_117946.2  NP_193570.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07861001 Os03g0786100 54.92(n)
    57.31(a)
      4334349  NM_001058022.1  NP_001051487.1 


    ENSEMBL Gene Tree for HAO1 (if available)
    TreeFam Gene Tree for HAO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HAO1 gene
    HAO22  
    1 SIMAP similar gene for HAO1 using alignment to 3 protein entries:     HAOX1_HUMAN (see all proteins):
    HAO2

    Find genes that share paralogs with HAO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HAO1 (see all 1370)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60389721,2
    C,F--7863173(+) gtgagT/Ctcttg 1 -- ds50014Minor allele frequency- C:0.15CSA WA 124
    rs622007721,2
    C--7863320(+) GGTATC/ACCCAT 1 -- ds50013Minor allele frequency- A:0.14NA 124
    rs1406936031,2
    C--7863471(+) AGCTA-/CCCTTG 1 -- ds50010--------
    rs60553631,2
    C,F,A,H--7863543(+) TAACCA/GATAAG 1 -- ds500123Minor allele frequency- G:0.21NS EA NA CSA WA 2650
    rs1403274471,2
    --7863547(+) CAATAA/GGGTAT 1 -- ds50010--------
    rs1840468551,2
    --7863553(+) GGTATA/GCAGAA 1 -- ds50010--------
    rs1503560851,2
    --7863631(+) GATATA/GTTCTT 1 -- ut310--------
    rs1872643121,2
    --7863752(+) ATTACC/TGCCAC 1 -- ut310--------
    rs1920912021,2
    --7863769(+) CAATTA/CTCTCC 1 -- ut310--------
    rs37479261,2
    C,F,A,H--7863999(+) GTTTTC/ATTTTT 1 -- ut31 trp316Minor allele frequency- A:0.19NS EA NA CSA WA 2218

    HapMap Linkage Disequilibrium report for HAO1 (7863628 - 7921121 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HAO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912652CNV Gain21882294
    nsv833915CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HAO1
    DNA2.0 Custom Variant and Variant Library Synthesis for HAO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605023    OMIM disorders: --

    1 disease for HAO1:    
    About MalaCards
    primary hyperoxaluria

    2 diseases from the University of Copenhagen DISEASES database for HAO1:
    Primary hyperoxaluria     Nephrolithiasis

    Find genes that share disorders with HAO1           About GenesLikeMe

    1 Novoseek inferred disease relationship for HAO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypoglycemia 0 1 17365439 (1)

    Genetic Association Database (GAD): HAO1
    Human Genome Epidemiology (HuGE) Navigator: HAO1 (1 document)

    Export disorders for HAO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HAO1 gene, integrated from 10 sources (see all 226):
    (articles sorted by number of sources associating them with HAO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. (PubMed id 10777549)1, 2, 9 Jones J.M.... Gould S.J. (J. Biol. Chem. 2000)
    2. Genome-wide association study of childhood acute lymphoblastic leukemia in Korea. (PubMed id 20189245)1, 4 Han S.... Kang D. (Leuk. Res. 2010)
    3. Structure of human glycolate oxidase in complex with the inhibitor 4- carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole. (PubMed id 20054120)1, 2 Bourhis J.M.... Lindqvist Y. (Acta Crystallogr. F 2009)
    4. Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design. (PubMed id 18215067)1, 2 Murray M.S.... Lowther W.T. (Biochemistry 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Identification and expression of a cDNA for human glycolate oxidase. (PubMed id 10978532)1, 2 Williams E.L.... Rumsby G. (Biochim. Biophys. Acta 2000)
    8. Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA. (PubMed id 9891009)1, 3 Kohler S.A....KA1hn L.C. (J. Biol. Chem. 1999)
    9. Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. (PubMed id 23263487)1 Jia W.H....Zheng W. (Nat. Genet. 2013)
    10. Stabilization of an intermediate in the oxidative half-reaction of human liver glycolate oxidase. (PubMed id 21141873)1 Pennati A. and Gadda G. (Biochemistry 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54363 HGNC: 4809 AceView: HAO1 Ensembl:ENSG00000101323 euGenes: HUgn54363
    ECgene: HAO1 Kegg: 54363 H-InvDB: HAO1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HAO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HAO1 gene:
    Search GeneIP for patents involving HAO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for HAO1 (Hydroxyacid Oxidase-1/HAO-1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for HAO1 (Hydroxyacid Oxidase-1/HAO-1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HAO1   OriGene RNAi products in human, mouse, rat for HAO1  
     OriGene qPCR primer pairs and template standards for HAO1   OriGene Protein Over-expression Lysate for HAO1  
     OriGene MassSpec for HAO1   OriGene clones in human, mouse for HAO1  
     OriGene qSTAR qPCR primer pairs in human, mouse for HAO1   OriGene Purified Protein for HAO1  
     OriGene ORF clones in mouse, rat for HAO1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HAO1   OriGene Custom Protein Services for HAO1  

     
     
     Block miRNA regulation of human, mouse, rat HAO1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HAO1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAO1 Predesigned siRNA for gene silencing in human, mouse, rat HAO1
     QuantiFast Probe-based Assays in human, mouse, rat HAO1 QuantiTect SYBR Green Assays in human, mouse, rat HAO1
     Custom PCR Arrays for HAO1 Search Chromatin IP Primers for HAO1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HAO1  Search GeneGlobe Interaction Network for HAO1
     Regulatory tfbs in HAO1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HAO1 GenScript cDNA clones with any tag delivered in your preferred vector for HAO1
     GenScript Custom Assay Services for HAO1 GenScript Custom overexpressing Cell Line Services for HAO1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HAO1 (HAOX1)
     Proteins for HAO1
     Browse Sino Biological Cell Lysates
     cDNA Clones for HAO1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HAO1 antibodies
     HAO1 proteins
     HAO1 lysates
     Antibodies for HAO1
     See all of Abcam's Antibodies, Kits and Proteins for HAO1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HAO1
     Proteins for HAO1
     Antibodies for HAO1
     ELISAs for HAO1
     CLIAs for HAO1



     Browse ESI BIO Cell Lines and PureStem Progenitors for HAO1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAO1
     SwitchGear 3'UTR luciferase reporter plasmids for HAO1
     SwitchGear Promoter luciferase reporter plasmids for HAO1
     Search ThermoFisher Antibodies for HAO1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAO1
     Browse compounds at ApexBio
     Addgene plasmids for HAO1
      Search eBioscience for proteins for HAO1
      Search eBioscience for elisas for HAO1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HAO1
     antibodies-online antibodies for HAO1 (41 products)
     antibodies-online kits for HAO1 (4 products)
     antibodies-online peptides for HAO1
     antibodies-online proteins for HAO1 (15 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HAO1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4