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Aliases for HAO1 Gene

Aliases for HAO1 Gene

  • Hydroxyacid Oxidase (Glycolate Oxidase) 1 2 3
  • GOX1 3 4 6
  • Glycolate Oxidase 3 4
  • HAOX1 3 4
  • GOX 3 4
  • (S)-2-Hydroxy-Acid Oxidase 3
  • Hydroxyacid Oxidase 1 3
  • EC 4

External Ids for HAO1 Gene

Previous HGNC Symbols for HAO1 Gene

  • GOX1

Previous GeneCards Identifiers for HAO1 Gene

  • GC20M007851
  • GC20M007858
  • GC20M007811

Summaries for HAO1 Gene

Entrez Gene Summary for HAO1 Gene

  • This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]

GeneCards Summary for HAO1 Gene

HAO1 (Hydroxyacid Oxidase (Glycolate Oxidase) 1) is a Protein Coding gene. Diseases associated with HAO1 include primary hyperoxaluria. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include receptor binding and (S)-2-hydroxy-acid oxidase activity. An important paralog of this gene is HAO2.

UniProtKB/Swiss-Prot for HAO1 Gene

  • Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAO1 Gene

Genomics for HAO1 Gene

Regulatory Elements for HAO1 Gene

Genomic Location for HAO1 Gene

7,882,981 bp from pter
7,940,474 bp from pter
57,494 bases
Minus strand

Genomic View for HAO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAO1 Gene

Proteins for HAO1 Gene

  • Protein details for HAO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hydroxyacid oxidase 1
    Protein Accession:
    Secondary Accessions:
    • Q14CQ0
    • Q9UPZ0
    • Q9Y3I7

    Protein attributes for HAO1 Gene

    370 amino acids
    Molecular mass:
    40924 Da
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HAO1 Gene

neXtProt entry for HAO1 Gene

Proteomics data for HAO1 Gene at MOPED

Post-translational modifications for HAO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HAO1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HAO1 (Hydroxyacid Oxidase-1/HAO-1)

No data available for DME Specific Peptides for HAO1 Gene

Domains for HAO1 Gene

Suggested Antigen Peptide Sequences for HAO1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UJM8
  • Contains 1 FMN hydroxy acid dehydrogenase domain.
  • Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
genes like me logo Genes that share domains with HAO1: view

No data available for Gene Families for HAO1 Gene

Function for HAO1 Gene

Molecular function for HAO1 Gene

GENATLAS Biochemistry:
hydroxyacid oxidase 1,glycolate oxidase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=141 uM for glycolate {ECO:0000269 PubMed:18215067}; KM=40 uM for 2-hydroxy octanoate {ECO:0000269 PubMed:18215067}; KM=2200 uM for glyoxylate {ECO:0000269 PubMed:18215067};
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.

Enzyme Numbers (IUBMB) for HAO1 Gene

Gene Ontology (GO) - Molecular Function for HAO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003973 (S)-2-hydroxy-acid oxidase activity IDA 10777549
GO:0005102 receptor binding IPI 20178365
GO:0008891 glycolate oxidase activity TAS --
GO:0010181 FMN binding IDA 18215067
GO:0015930 glutamate synthase activity --
genes like me logo Genes that share ontologies with HAO1: view

Phenotypes for HAO1 Gene

GenomeRNAi human phenotypes for HAO1:
genes like me logo Genes that share phenotypes with HAO1: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HAO1 Gene

Localization for HAO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAO1 Gene


Subcellular locations from

Jensen Localization Image for HAO1 Gene COMPARTMENTS Subcellular localization image for HAO1 gene
Compartment Confidence
peroxisome 5
chloroplast 2
cytosol 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for HAO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA 10777549
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with HAO1: view

Pathways for HAO1 Gene

genes like me logo Genes that share pathways with HAO1: view

Pathways by source for HAO1 Gene

UniProtKB/Swiss-Prot Q9UJM8-HAOX1_HUMAN

  • Pathway: Organic acid metabolism; glycolate degradation; 3-phospho-D-glycerate from glycolate: step 1/4

Gene Ontology (GO) - Biological Process for HAO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001561 fatty acid alpha-oxidation IDA 18215067
GO:0006537 glutamate biosynthetic process --
GO:0006979 response to oxidative stress IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with HAO1: view

Compounds for HAO1 Gene

(5) HMDB Compounds for HAO1 Gene

Compound Synonyms Cas Number PubMed IDs
Flavin Mononucleotide
  • FMN
Glycolic acid
  • 2-Hydroxyacetate
Glyoxylic acid
  • Formylformate
Hydrogen peroxide
  • Hydrogen peroxide
  • Oxygen

(10) Drugbank Compounds for HAO1 Gene

(52) Novoseek inferred chemical compound relationships for HAO1 Gene

Compound -log(P) Hits PubMed IDs
glucose 82.3 167
nafion 82.2 7
agcl 78.1 1
fadh2 77.4 5
poly(dimethyl diallyl ammonium chloride) 77.1 5
genes like me logo Genes that share compounds with HAO1: view

Transcripts for HAO1 Gene

mRNA/cDNA for HAO1 Gene

(9) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HAO1 Gene

Hydroxyacid oxidase (glycolate oxidase) 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAO1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAO1 Gene

No ASD Table

Relevant External Links for HAO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HAO1 Gene

mRNA expression in normal human tissues for HAO1 Gene

mRNA differential expression in normal tissues according to GTEx for HAO1 Gene

This gene is overexpressed in Liver (52.4).

Protein differential expression in normal tissues for HAO1 Gene

This gene is overexpressed in Liver (30.9), Gallbladder (23.2), and Liver, secretome (11.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HAO1 Gene

SOURCE GeneReport for Unigene cluster for HAO1 Gene Hs.193640

mRNA Expression by UniProt/SwissProt for HAO1 Gene

Tissue specificity: Liver
genes like me logo Genes that share expressions with HAO1: view

Expression partners for HAO1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HAO1 Gene

Orthologs for HAO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HAO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia HAO1 35
  • 89.37 (n)
  • 90.81 (a)
HAO1 36
  • 91 (a)
(Mus musculus)
Mammalia Hao1 35
  • 87.12 (n)
  • 89.46 (a)
Hao1 16
Hao1 36
  • 89 (a)
(Pan troglodytes)
Mammalia HAO1 35
  • 99.46 (n)
  • 100 (a)
HAO1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hao1 35
  • 85.86 (n)
  • 89.46 (a)
(Bos Taurus)
Mammalia HAO1 36
  • 92 (a)
(Monodelphis domestica)
Mammalia HAO1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia HAO1 36
  • 80 (a)
(Gallus gallus)
Aves HAO1 35
  • 71.64 (n)
  • 73.98 (a)
HAO1 36
  • 73 (a)
(Anolis carolinensis)
Reptilia HAO1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1958 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3534 35
(Danio rerio)
Actinopterygii Dr.2132 35
hao1 35
  • 65.48 (n)
  • 68.49 (a)
hao1 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18003 37
  • 48 (a)
CG18003 35
  • 54.08 (n)
  • 48.73 (a)
CG18003 36
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010885 35
  • 53.41 (n)
  • 52.56 (a)
(Caenorhabditis elegans)
Secernentea F41E6.5 37
  • 46 (a)
F41E6.5 35
  • 51.81 (n)
  • 46.86 (a)
F41E6.5 36
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYB2 36
  • 25 (a)
CYB2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18360 35
  • 55.97 (n)
  • 57.67 (a)
(Oryza sativa)
Liliopsida Os03g0786100 35
  • 54.92 (n)
  • 57.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
Species with no ortholog for HAO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HAO1 Gene

Gene Tree for HAO1 (if available)
Gene Tree for HAO1 (if available)

Paralogs for HAO1 Gene

Paralogs for HAO1 Gene

Selected SIMAP similar genes for HAO1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HAO1: view

Variants for HAO1 Gene

Sequence variations from dbSNP and Humsavar for HAO1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs941425 -- 7,924,636(-) TTCTG(C/T)TTGAA intron-variant
rs941426 -- 7,924,403(-) TGGAT(C/T)TGACA intron-variant
rs1028310 -- 7,916,679(-) TTATT(A/T)CATTT intron-variant
rs1540901 -- 7,913,627(-) AAAAC(A/C)ATATA intron-variant
rs1569453 -- 7,918,944(-) ATGAG(A/T)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAO1 Gene

Variant ID Type Subtype PubMed ID
nsv912652 CNV Gain 21882294
nsv833915 CNV Gain 17160897

Relevant External Links for HAO1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAO1 Gene

Disorders for HAO1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HAO1 Gene in MalaCards »

(1) Diseases for HAO1 Gene including...

(2) University of Copenhagen DISEASES for HAO1 Gene

(1) Novoseek inferred disease relationships for HAO1 Gene

Disease -log(P) Hits PubMed IDs
hypoglycemia 0 1

Relevant External Links for HAO1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HAO1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for HAO1 Gene

Publications for HAO1 Gene

  1. Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. (PMID: 10777549) Jones J.M. … Gould S.J. (J. Biol. Chem. 2000) 3 4 23
  2. Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA. (PMID: 9891009) Kohler S.A. … KA1hn L.C. (J. Biol. Chem. 1999) 2 3
  3. Identification and expression of a cDNA for human glycolate oxidase. (PMID: 10978532) Williams E.L. … Rumsby G. (Biochim. Biophys. Acta 2000) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HAO1 Gene

Sources for HAO1 Gene

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