Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HAND2 Gene

protein-coding   GIFtS: 57
GCID: GC04M174447

heart and neural crest derivatives expressed 2
 Explore 7 diseases affiliated with
HAND2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HAND2    

Aliases
for HAND2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heart And Neural Crest Derivatives Expressed 21 2     DHAND22 5
BHLHa261     DHAND3 5
Hed1 2     Basic Helix-Loop-Helix Transcription Factor HAND22
Thing21 2     Heart- And Neural Crest Derivatives-Expressed Protein 22
DHand1     BHLHA263
Class A Basic Helix-Loop-Helix Protein 262 3     DHAND3 5
Deciduum, Heart, Autonomic Nervous System And Neural Crest
Derivatives-Expressed Protein 22 3
     

External Ids:    HGNC: 48081   Entrez Gene: 94642   Ensembl: ENSG000001641077   OMIM: 6024075   UniProtKB: P612963   

Export aliases for HAND2 gene to outside databases

Previous GC identifers: GC04M175366 GC04M174984 GC04M175142 GC04M174820 GC04M174685 GC04M170194


Summaries
for HAND2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HAND2:
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene
product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the
developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary
fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators
of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch
development. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HAND2_HUMAN, P61296
Function: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic
arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling
pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior
polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the
development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box
consensus sequence 5'-CANNTG-3' (By similarity)

Gene Wiki entry for HAND2


Genomic Views
for HAND2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HAND2 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   Nkx2-5   MEF-2A   AP-2alpha isoform 4   aMEF-2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HAND2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HAND2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAND2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q33   Ensembl cytogenetic band:  4q34.1   HGNC cytogenetic band: 4q33

HAND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAND2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M174447:  view genomic region     (about GC identifiers)

Start:
 174,446,120 bp from pter      End:
 174,451,380 bp from pter
Size:
 5,261 bases      Orientation:
 minus strand

Proteins
for HAND2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HAND2_HUMAN, P61296 (See protein sequence)
Recommended Name: Heart- and neural crest derivatives-expressed protein 2  
Size: 217 amino acids; 23666 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with
TCF3 gene products E12 and E47, HAND1 and HEY1, HEY2 and HEYL (hairy-related transcription factors) (By similarity)
Subcellular location: Nucleus (By similarity)
Developmental stage: Expressed in the fetal heart
Secondary accessions: B6ECG9 O95300 O95301 P97833

Explore the universe of human proteins at neXtProt for HAND2: NX_P61296

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61296

    • HAND2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_068808.1  
    ENSEMBL proteins: 
     ENSP00000427084   ENSP00000352565  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HAND2
    OriGene Custom Protein Services for HAND2 
    GenScript Custom Purified and Recombinant Proteins Services for HAND2
    Novus Biologicals HAND2 Proteins
    Novus Biologicals HAND2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HAND2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA16280598
    GO:0005634nucleus ----
    GO:0005667transcription factor complex ISS--
    GO:0043234protein complex IDA15486975


    HAND2 for ontologies           About GeneDecksing



    HAND2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HAND2
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HAND2 
    GenScript Custom Superior Antibodies Services for HAND2
    Novus Biologicals HAND2 Antibodies
    Search for Antibodies for HAND2 at Abcam  
    Uscn Antibodies for HAND2
    ThermoFisher Antibodies for HAND2

    Assay Products for HAND2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HAND2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HAND2

    Protein Domains /
    Families
    for HAND2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HAND2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry P61296

    ProtoNet protein and cluster: P61296

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: HAND2_HUMAN, P61296
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for HAND2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HAND2_HUMAN, P61296
    Function: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic
    arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling
    pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior
    polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the
    development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box
    consensus sequence 5'-CANNTG-3' (By similarity)

         Genatlas biochemistry entry for HAND2:
    heart and neural crest derivatives expressed 2,also expressed in the deciduum,murine bHAND homolog,activating UFD1L in
    neural crest mesenchyme,acting in a complementary fashion with HAND1 in the formation of right ventricles and aortic
    arches

    miRNA
    Products:            		miRTarBase miRNAs that target HAND2:
    hsa-mir-1 (MIRT001843)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAND2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate HAND2 (see all 34):
    hsa-miR-140-5p hsa-miR-607 hsa-miR-128 hsa-miR-25 hsa-miR-519a hsa-miR-877* hsa-miR-3909 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: HAND2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAND2 (see all 7)
    OriGene shRNA RFP: HAND2
    OriGene siRNA: HAND2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAND2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HAND2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAND2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAND2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HAND2 (NM_021973)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAND2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAND2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HAND2
    LifeMap BioReagents: cell lines associated with HAND2: PureStem MEL2, NCr-fac Progenitor,
    PureStem Z11, Meso Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAND2

    Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IDA16280598
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA15486975
    GO:0003680AT DNA binding IDA15486975
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003713transcription coactivator activity ISS--


    HAND2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for HAND2: Hand2tm1Eno Hand2tm1.2Zllr Hand2tm1Dsr
         15/18 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Hand2) (see all 18):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  limbs/digits/tail  liver/biliary system  mortality/aging  muscle 

    HAND2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HAND2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NFAT and Cardiac Hypertrophy
    		NFAT and Cardiac Hypertrophy1.00
    		Signaling Involved in Cardiac Hypertrophy0.42
    2Heart Development
    		Heart Development1.00

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HAND2
        NFAT and Cardiac Hypertrophy
    Signaling Involved in Cardiac Hypertrophy

    1 BioSystems Pathway for HAND2 
        Heart Development


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HAND2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/16 Interacting proteins for HAND2 (P612963 ENSP000003525654) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    HEYLQ9NQ873, ENSP000003619434I2D: score=2 STRING: ENSP00000361943
    PHOX2AO148133, ENSP000002982314I2D: score=2 STRING: ENSP00000298231
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    TCF3P159233, ENSP000002629654I2D: score=3 STRING: ENSP00000262965
    About this table

    Gene Ontology (GO): 5/40 biological process terms (GO ID links to tree view) (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001701in utero embryonic development ISS--
    GO:0001947heart looping ISS--
    GO:0001967suckling behavior IEA--
    GO:0003007heart morphogenesis ISS--


    HAND2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HAND2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HAND2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HAND2
    3 Novoseek chemical compound relationships for HAND2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    norepinephrine 25.4 2 14512028 (1), 16280598 (1)
    tyrosine 0 3 18724272 (1), 15649470 (1)
    dopamine 0 3 16280598 (1), 14506227 (1)

    Search CenterWatch for drugs/clinical trials and news about HAND2 

    Transcripts
    for HAND2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HAND2 gene: 
    NM_021973.2  

    Unigene Cluster for HAND2:

    Heart and neural crest derivatives expressed 2
    Hs.388245  [show with all ESTs]
    Unigene Representative Sequence: NM_021973
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503024 ENST00000359562(uc003itg.1 uc003ith.1) ENST00000505300


    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HAND2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate HAND2 (see all 34):
    hsa-miR-140-5p hsa-miR-607 hsa-miR-128 hsa-miR-25 hsa-miR-519a hsa-miR-877* hsa-miR-3909 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: HAND2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAND2 (see all 7)
    OriGene shRNA RFP: HAND2
    OriGene siRNA: HAND2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAND2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAND2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAND2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HAND2 (NM_021973)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAND2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAND2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAND2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HAND2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAND2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAND2

    Additional cDNA sequence: 

    AF087940.1 AK122739.1 BC101406.1 BC101974.1 BC109383.1 FJ226608.1 

    6 DOTS entries:

    DT.441870  DT.101967388  DT.101959298  DT.121217200  DT.121217204  DT.95269853 

    24/56 AceView cDNA sequences (see all 56):

    CB216748 AA402116 BP375336 AW872910 AA228070 AA228069 CR613998 AI021959 
    AA553383 CF527763 BI042724 AI382843 BF206131 BQ788078 BM804753 AA262355 
    BG953656 AF087940 CF528508 BM730141 BX404434 BI195868 BQ270188 AA232841 

    GeneLoc Exon Structure


    Expression
    for HAND2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HAND2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACCTGCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HAND2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/18 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 18) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Head MesenchymeBranchial Arch 2Cranial Neural Crest CellsNeural Crest
    Head MesenchymeBranchial Arch 3,4,6Cardiac Neural Crest CellsNeural Crest
    HeartCardiac CrescentCardiac Crescent CellsMyocardium
    HeartHeart TubeHeart Tube CellsMyocardium
    HeartMyocardiumCardiomyocytesMyocardium
    HeartOuter CurvatureCardiomyocytesMyocardium
    HeartOutflow TractCardiomyocytesMyocardium
    HeartPrimitive Heart TubePrimitive Heart Tube CellsMyocardium
    HeartRight VentricleCardiomyocytesMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Trophoblast-like cells (Generation of tropho...)
    Primordial germ cell-like cells (Reconstitution of mo...)
    HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)Bone

    See HAND2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HAND2

    SOURCE GeneReport for Unigene cluster: Hs.388245

    UniProtKB/Swiss-Prot: HAND2_HUMAN, P61296
    Tissue specificity: Heart

        SABiosciences Expression via Pathway-Focused PCR Arrays including HAND2: 
              Cell Lineage Identification in human mouse rat
              Transcription Factors in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAND2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HAND2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAND2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAND2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAND2

    Orthologs
    for HAND2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HAND2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HAND26
    		 heart and neural crest derivatives expressed 2
    		 95(a)
    		 1 ↔ 1
    		 4(44835554-44939186)
    lizard
    (Anolis carolinensis)    		 Reptilia HAND26
    		 --
    		 81(a)
    		 1 ↔ 1
    		 3(144377788-144392490)
    African clawed frog
    (Xenopus laevis)    		 Amphibia hand2-A2 heart and neural crest derivatives expressed 2 83.22(n)    AF286645.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hand22 heart and neural crest derivatives expressed transcript more 75.19(n)   58150  AF228334.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hand1 CG18144-PA 51.47(n)
    60.8(a)    		   34379  NM_135526.2  NP_609370.2 


    ENSEMBL Gene Tree for HAND2 (if available)
    TreeFam Gene Tree for HAND2 (if available) 

    Paralogs
    for HAND2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HAND2 gene
    TCF242  NHLH12  TWIST12  TWIST22  TAL12  TCF232  LYL12  NHLH22  
    TAL22  TCF152  SCXB2  TCF212  HAND12  MSC2  SCXA2  
    9 SIMAP similar genes for HAND2 using alignment to 6 protein entries:     HAND2_HUMAN (see all proteins):
    HAND1    TCF21    TAL2    NHLH2    SCL    SCXA
    SCXB    TCF24    TCF15

    HAND2 for paralogs           About GeneDecksing



    Genomic Variants
    for HAND2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): HAND2
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HAND2
    DNA2.0 Custom Variant and Variant Library Synthesis for HAND2

    Disorders / Diseases
    for HAND2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HAND2 for disorders           About GeneDecksing

    OMIM gene information: 602407    OMIM disorders: --

    7 diseases for HAND2:    About MalaCards
    split hand/foot malformation    saethre-chotzen syndrome    polydactyly    hematopoiesis
    cardiomyopathy    neuroblastoma    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for HAND2:
    Polydactyly     Congenital heart defect

    1 Novoseek disease relationship for HAND2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    saethre-chotzen syndrome 73.1 1 15735646 (1)

    Human Genome Epidemiology (HuGE) Navigator: HAND2 (2 documents)

    Export disorders for HAND2 gene to outside databases

    Publications
    for HAND2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HAND2 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with HAND2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human HAND2 gene. (PubMed id 9878849)1, 2, 3 Russell M.W.... Izumo S. (1998)
    2. Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma. (PubMed id 19348682)1, 2 Voth H.... Fischer M. (2009)
    3. The interaction between dHAND and Arix at the dopamine beta-hydroxylase promoter region is independent of direct dHAND binding to DNA. (PubMed id 14506227)1, 9 Rychlik J.L....Lewis E.J. (2003)
    4. Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. (PubMed id 19008477)1, 9 Morikawa Y. and Cserjesi P. (2008)
    5. Cooperative activation of atrial naturetic peptide promoter by dHAND and MEF2C. (PubMed id 15486975)1, 9 Zang M.X....Jing H. (2004)
    6. Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type. (PubMed id 16280598)1, 9 Rychlik J.L....Lewis E.J. (2005)
    7. A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. (PubMed id 11076755)1, 9 McFadden D.G....Olson E.N. (2000)
    8. PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. (PubMed id 14636580)1, 9 Firulli B.A....Firulli A.B. (2003)
    9. No evidence of HAND2 involvement in nonsyndromic cleft lip with or without cleft palate. (PubMed id 21431856)1 Martinelli M....Scapoli L. (2012)
    10. A Phox2- and Hand2-dependent Hand1 cis-regulatory elem ent reveals a unique gene dosage requirement for Hand2 during sympathetic neurog enesis. (PubMed id 22323723)1 Vincentz J.W....Firulli A.B. (2012)

    External Searches for HAND2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HAND2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9464 HGNC: 4808 AceView: HAND2 Ensembl:ENSG00000164107 euGenes: HUgn9464
    ECgene: HAND2 H-InvDB: HAND2

    Other Databases showing HAND2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HAND2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HAND2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HAND2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HAND2 gene:
    Search GeneIP for patents involving HAND2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HAND2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for HAND2 (HAND2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HAND2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HAND2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HAND2  
     OriGene Protein Over-expression Lysate for HAND2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HAND2   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HAND2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HAND2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HAND2   OriGene Custom Protein Services for HAND2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HAND2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HAND2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAND2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HAND2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HAND2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HAND2
     GenScript Custom Purified and Recombinant Proteins Services for HAND2 GenScript cDNA clones with any tag delivered in your preferred vector for HAND2
     GenScript Custom Assay Services for HAND2 GenScript Custom Superior Antibodies Services for HAND2
     GenScript Custom overexpressing Cell Line Services for HAND2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HAND2 promoter
     Search Chromatin IP Primers for HAND2
     RT2 qPCR Primer Assay in human, mouse, rat HAND2
     GNC Network for HAND2
     SABiosciences PCR Arrays including human, mouse, rat HAND2
     Search Tocris compounds for HAND2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HAND2 antibodies
     HAND2 proteins
     HAND2 lysates
     Search for Antibodies for HAND2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HAND2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HAND2 Proteins, Antibodies, CLIAs, and ELISAs
     Cell Lines associated with HAND2: PureStem MEL2, NCr-fac Progenitor,
    PureStem Z11, Meso Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAND2
     SwitchGear 3'UTR luciferase reporter plasmids for HAND2
     SwitchGear Promoter luciferase reporter plasmids for HAND2
     ThermoFisher Antibodies for HAND2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAND2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HAND2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4