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HAND2 Gene

protein-coding GIFtS: 56

GC04M174685

heart and neural crest derivatives expressed 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DHAND ^³, ⁵
DHAND2 ^², ⁵
FLJ16260 ^²
Hed ^¹, ²
MGC125303 ^²
MGC125304 ^²
Thing2 ^¹, ²
bHLHa26 ^¹, ²
dHAND ^³
dHand ^¹, ²

Descriptions
Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 ^³
basic helix-loop-helix transcription factor HAND2 ^²
heart and neural crest derivatives expressed 2 ^²

External Ids
HGNC: 4808¹
Entrez Gene: 9464²
UniProtKB: P61296³
Ensembl: ENSG00000164107⁷

Search outside databases for aliases for HAND2 gene

Previous GC identifers: GC04M175366 GC04M174984 GC04M175142 GC04M174820

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HAND2:

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription

factors. This gene product is one of two closely related family members, the HAND proteins, which

are asymmetrically expressed in the developing ventricular chambers and play an essential role in

cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the

right ventricle and aortic arch arteries, implicating them as mediators of congenital heart

disease. In addition, this transcription factor plays an important role in limb and branchial arch

development. [provided by RefSeq]

UniProtKB/Swiss-Prot: HAND2_HUMAN, P61296

Function: Essential for cardiac morphogenesis, particularly for the formation of the right

ventricle and of the aortic arch arteries. Required for vascular development and regulation of

angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb

development, particularly in the establishment of anterior-posterior polarization, acting as an

upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the

development of branchial arches, which give rise to unique structures in the head and neck. Binds

DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity)

Gene Wiki entry for HAND2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HAND2 gene

Entrez Gene cytogenetic band: 4q33 Ensembl cytogenetic band: 4q34.1 HGNC cytogenetic band: 4q33

HAND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M174685: (about GC identifiers)

Start:	174,684,227 bp from pter
End:	174,687,953 bp from pter
Size:	3,727 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_022792.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HAND2_HUMAN, P61296 (See protein sequence)

Recommended Name: Heart- and neural crest derivatives-expressed protein 2

Size: 217 amino acids; 23666 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers

and heterodimers with TCF3 gene products E12 and E47, HAND1 and HEY1, HEY2 and HEYL (hairy-related

transcription factors) (By similarity)

Subcellular location: Nucleus (By similarity)

Developmental stage: Expressed in the fetal heart

Secondary accessions: O95300 O95301 P97833

REFSEQ proteins: NP_068808.1

ENSEMBL proteins:

ENSP00000377290 ENSP00000352565

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HAND2)
	Human Recombinant Proteins from Abnova (HAND2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005667	transcription factor complex	IEA	--

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Antibodies for HAND2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HAND2
	R&D Systems Antibodies for HAND2
	Antibodies from Abcam (HAND2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for HAND2

Assays for HAND2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P61296

ProtoNet protein and cluster: P61296

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: HAND2_HUMAN, P61296

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAND2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HAND2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021973

Applied Biosystems Silencer® siRNAs for HAND2

Sigma-Aldrich siRNA for HAND2

Sigma-Aldrich shRNA for HAND2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HAND2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_021973
Myc/DDK tagged cDNA clone in CMV expression vector: NM_021973
untagged cDNA clone in CMV expression vector: NM_021973

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021973

UniProtKB/Swiss-Prot: HAND2_HUMAN, P61296

Function: Essential for cardiac morphogenesis, particularly for the formation of the right

ventricle and of the aortic arch arteries. Required for vascular development and regulation of

angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb

development, particularly in the establishment of anterior-posterior polarization, acting as an

upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the

development of branchial arches, which give rise to unique structures in the head and neck. Binds

DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity)

Genatlas biochemistry entry for HAND2:

heart and neural crest derivatives expressed 2,also expressed in the deciduum,murine bHAND

homolog,activating UFD1L in neural crest mesenchyme,acting in a complementary fashion with HAND1

in the formation of right ventricles and aortic arches

15/16 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Hand2) (see all 16 ):

	behavior/neurological	cellular	craniofacial	digestive/alimentary
embryogenesis	growth/size	hearing/vestibular/ear	homeostasis/metabolism	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	muscle	nervous system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	9500550 9878849
GO:0042802	identical protein binding	IEA	--
GO:0046982	protein heterodimerization activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for HAND2 (Your Favorite Gene powered by Ingenuity)

Cardiac Hypertrophy Signaling

GeneDecks HAND2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HAND2

5/46 Interacting proteins for HAND2 (ENSP00000352565³) via UniProtKB, MINT, and/or STRING (see all 46 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NKX2-5	ENSP00000327758³	STRING (score=.982)
HAND1	ENSP00000231121³	STRING (score=.964)
SHH	ENSP00000297261³	STRING (score=.952)
GATA4	ENSP00000334458³	STRING (score=.947)
BMP4	ENSP00000245451³	STRING (score=.946)

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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001701	in utero embryonic development	IEA	--
GO:0001947	heart looping	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006915	apoptosis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HAND2
1 Novoseek chemical compound relationship for HAND2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	0.00	3	18724272 (1), 15649470 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAND2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HAND2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021973

Sigma-Aldrich siRNA for HAND2

Sigma-Aldrich shRNA for HAND2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_021973

REFSEQ mRNAs for HAND2 gene:

NM_021973.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_021973

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021973
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021973
                                 untagged cDNA clone in CMV expression vector: NM_021973

Additional cDNA sequence:

AF087940.1 AK122739.1 BC101406.1 BC101974.1 BC109383.1 FJ226608.1

6 DOTS entries:

DT.441870 DT.101967388 DT.101959298 DT.121217200 DT.121217204 DT.95269853

24/56 AceView cDNA sequences (see all 56 ):

AA228070 AA228069 BP375336 CB216748 AW872910 CR613998 AA553383 AI021959

AA402116 AA232841 BU624590 AL709273 BQ270188 AK122739 AF087940 BI042724

BX404434 BI195868 BF206131 AA319613 BX283484 BG953656 BQ011016 AA262355

highest scoring ESTs for HAND2:

AF087940 AI651666 BF206131 BF313018 BI195112 BX283484 N88945 AA262355 AI652225 BI195868

Unigene Cluster for HAND2:

Heart and neural crest derivatives expressed 2

Hs.388245 [show with all ESTs]

Unigene Representative Sequence: NM_021973

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000393686 ENST00000359562

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HAND2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HAND2

¹ / ² / ³

4 probe-sets matching HAND2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
68465_at²^{, 3}	U95-D	1	1.00	1.00	0.74	1.43	AI651666	0.80	1.00	0.91	1
45131_at²^{, 3}	U95-B	1	0.38	1.00	0.95	0.61	AA262355	0.60	1.00	0.82	1
220480_at²^{, 3}	U133-A	1	0.36	1.00	--	--	NM_021973	0.60	1.00	0.82	1
220480_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--

GeneDecks HAND2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GACCTGCTGG

SOURCE GeneReport for Unigene cluster: Hs.388245
UniProtKB/Swiss-Prot: HAND2_HUMAN, P61296
Tissue specificity: Heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HAND2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HAND2¹	--	heart and neural crest derivatives expressed 2	96.23(n) 98.31(a)	607431 XM_844096.1 XP_849189.1
chimpanzee (Pan troglodytes)	HAND2¹	--	heart and neural crest derivatives expressed 2	100(n) 100(a)	741581 XM_001156041.1 XP_001156041.1
rat (Rattus norvegicus)	Hand2¹	--	heart and neural crest derivatives expressed 2	93.55(n) 100(a)	64637 NM_022696.1 NP_073187.1
mouse (Mus musculus)	Hand2^{1, 5}	8 (30.00 cM)⁵	heart and neural crest derivatives expressed transcript more^{1, 5}	94.01(n)¹ 99.54(a)¹	15111¹ NM_010402.3¹ NP_034532.2¹ AI225906⁵ AI661148⁵ (see all 12)
chicken (Gallus gallus)	HAND2¹	--	heart and neural crest derivatives expressed 2	83.72(n) 87.91(a)	395813 NM_204966.1 NP_990297.1

About this table Species with no ortholog for HAND2

ENSEMBL Gene Tree for HAND2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HAND2 gene

TWIST1² TCF15² SCXB² HAND1² SCXA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/26 NCBI SNPs in HAND2 are shown (see all 26 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 61)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2119788^1,2	A,C,F,H,O	174683964(-)	`CTGAAA/GTCAAT`	1	--	ng5¹		21		NS EA NA EU WA	1518
	rs4146860^1,2	A,C,F,H	174689327(+)	`CTGGGA/GCTCGC`	1	--	ng3¹		4		EU EA WA	396
--	rs10024737^1,2	A,C,F,H	174684718(+)	`ATCTAT/CGAGAC`	1	--	ut3¹		4		EU EA WA	412
	rs17059546^1,2	C,F,H	174689637(+)	`GCGGCC/TGGGCG`	1	--	ng3¹		16		NA EU EA WA	1474
	rs13141356^1,2	C,F,H	174683937(+)	`ACTGAC/AGGCCT`	1	--	ng5¹		11		NA EU EA WA	982
	rs13146346^1,2	C,F,H	174689912(+)	`TGGTTC/TTTCAA`	1	--	ng3¹		15		NA EU EA WA	1392
	rs10520260^1,2	C,F,H	174683924(+)	`TCTCCA/GAACAA`	1	--	ng5¹		17		NS EU EA WA NA	1156
	rs2276940^1,2	F,H	174688574(-)	`AACCGG/TGGTAA`	1	--	ng3¹		5		EA EU WA	1912
	rs2276941^1,2	F,H	174688229(-)	`GGGGGG/AAAAAT`	1	--	ng3¹ trp³		3		EA WA	298
--	rs3840503^1,2	C	174688151(+)	`GGGGG-/GCAGGG`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for HAND2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602407

1 Novoseek disease relationship for HAND2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
saethre-chotzen syndrome	74.20	1	15735646 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/57 PubMed articles for HAND2 gene (see all 57 ):

Molecular cloning of the human HAND2 gene. (PubMed id 9878849)^{2, 3, 4} Russell M.W.... Izumo S. (1998)
The interaction between dHAND and Arix at the dopamine beta-hydroxylase promoter region is independent of direct dHAND binding to DNA. (PubMed id 14506227)^{1, 3} Rychlik J.L....Lewis E.J. (2003)
Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. (PubMed id 19008477)^{1, 3} Morikawa Y. and Cserjesi P. (2008)
Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type. (PubMed id 16280598)^{1, 3} Rychlik J.L....Lewis E.J. (2005)
A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. (PubMed id 11076755)^{1, 3} McFadden D.G....Olson E.N. (2000)
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. (PubMed id 14636580)^{1, 3} Firulli B.A....Firulli A.B. (2003)
Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma. (PubMed id 19348682)³ Voth H....Fischer M. (2009)
Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis. (PubMed id 16467358)³ Han Z....Olson E.N. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Differential cooperation between dHAND and three different E-proteins. (PubMed id 15351717)³ Murakami M....Kurihara H. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9464	HGNC: 4808	AceView: HAND2	Ensembl:ENSG00000164107	euGenes: HUgn9464
ECgene: HAND2	H-InvDB: HAND2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for HAND2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for HAND2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HAND2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HAND2		Antibodies for HAND2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HAND2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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HAND2 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for HAND2

Summaries
for HAND2

Genomic Location
for HAND2

Proteins
for HAND2

Protein Domains/
Families
for HAND2

Gene Function
for HAND2

Pathways & Interactions
for HAND2

Drugs & Compounds
for HAND2

Transcripts
for HAND2

Expression
for HAND2

Orthologs
for HAND2

Paralogs
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SNPs/Variants
for HAND2

Disorders & Mutations
for HAND2

Medical News
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Publications
for HAND2

Search for HAND2

Genome Databases showing HAND2

Other Databases showing HAND2

Specialized Databases showing HAND2

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HAND2 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor HAND2

Summariesfor HAND2

Genomic Locationfor HAND2

Proteinsfor HAND2

Protein Domains/Familiesfor HAND2

Gene Functionfor HAND2

Pathways & Interactionsfor HAND2

Drugs & Compoundsfor HAND2

Transcriptsfor HAND2

Expression for HAND2

Orthologsfor HAND2

Paralogsfor HAND2

SNPs/Variantsfor HAND2

Disorders & Mutationsfor HAND2

Medical Newsfor HAND2

Publicationsfor HAND2

Search for HAND2

Genome Databases showing HAND2

Other Databases showing HAND2

Specialized Databases showing HAND2

Licensable Technologiesfor HAND2

Servicesfor HAND2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HAND2

Summaries
for HAND2

Genomic Location
for HAND2

Proteins
for HAND2

Protein Domains/
Families
for HAND2

Gene Function
for HAND2

Pathways & Interactions
for HAND2

Drugs & Compounds
for HAND2

Transcripts
for HAND2

Expression
for HAND2

Orthologs
for HAND2

Paralogs
for HAND2

SNPs/Variants
for HAND2

Disorders & Mutations
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