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HAMP Gene

protein-coding GIFtS: 53

GC19P035773

hepcidin antimicrobial peptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
hepcidin antimicrobial peptide¹ ²		Liver-expressed antimicrobial peptide 1² ³
LEAP1¹ ² ³ ⁵		Putative liver tumor regressor² ³
HEPC¹ ² ³ ⁵		PLTR² ³
HFE2B¹ ² ⁵		hepcidin²
LEAP-1¹ ³

External Ids:	HGNC: 15598¹	Entrez Gene: 57817²	Ensembl: ENSG00000105697⁷	UniProtKB: P81172³

Search outside databases for aliases for HAMP gene

Previous GC identifers: GC19P036390 GC19P036222 GC19P040447 GC19P040465

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAMP:

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the

regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is

post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in

cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit

antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis,

a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. (provided

by RefSeq)

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172

Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in

conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)

Function: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus

and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa

Gene Wiki entry for HAMP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HAMP gene upstream (promoter) region

:
HNF-4alpha2 ATF deltaCREB CREB p300 c-Myc Max1 C/EBPalpha Max COUP-TF1

Epigenetics:

SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for HAMP:

MePH24426-2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.1

HAMP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P035773: view genomic region (about GC identifiers)

Start:	35,773,410 bp from pter
End:	35,776,046 bp from pter
Size:	2,637 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.9 NT_011109.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172 (See protein sequence)

Recommended Name: Hepcidin precursor

Size: 84 amino acids; 9408 Da

Subcellular location: Secreted

Mass spectrometry: Mass=2789.8; Method=MALDI; Range=60-84; Source=PubMed:11034317;

PDB structures from and Proteopedia :

1M4E (3D)

1M4F (3D)

2KEF (3D)

3H0T (3D)

Secondary accessions: Q1HE14 Q9BY68

REFSEQ proteins: NP_066998.1

ENSEMBL proteins:

ENSP00000222304

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	HuPro® and/or Recombinant Proteins from Abnova for HAMP
	Browse Origene full length recombinant human proteins expressed in human HEK293 cells
	Novus Biologicals Protein for HAMP
	Novus Biologicals Lysate for HAMP
	Browse Sino Biological Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	11034317
GO:0005737	cytoplasm	IEA	--
GO:0045179	apical cortex	IEA	--

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HAMP for ontologies About GeneDecksing

Antibodies for HAMP:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HAMP
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	Monoclonal and Polyclonal Antibodies from Abnova (HAMP)
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	Novus Biologicals Antibodies for HAMP
	Browse antibodies at Epitomics

Assays for HAMP:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Browse Enzo Life Sciences for kits & assays

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HAMP for domains About GeneDecksing

1 InterPro domain/family:

IPR010500 Hepcidin

Graphical View of Domain Structure for InterPro Entry P81172

ProtoNet protein and cluster: P81172

1 Blocks protein family: IPB010500 Hepcidin

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172

Similarity: Belongs to the hepcidin family

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HAMP)
		Origene 29mer shRNA kits in GFP-retroviral vector: HAMP Origene shRNA RFP: HAMP Origene basic RS shRNA: HAMP
		Applied Biosystems Silencer® siRNAs for HAMP
		Sigma-Aldrich siRNA for HAMP Sigma-Aldrich shRNA for HAMP Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector: HAMP Origene Myc/DDK tagged cDNA clones in CMV expression vector: HAMP Origene untagged cDNA clones in CMV expression vector: HAMP
		Browse Sino Biological Human cDNA Clones

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172

Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in

conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)

Function: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus

and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IEA	--

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HAMP for ontologies About GeneDecksing

Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hamp):

growth/size

hematopoietic system

homeostasis/metabolism

immune system

HAMP for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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HAMP for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" Pathway for HAMP (Your Favorite Gene powered by Ingenuity)

Acute Phase Response Signaling

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HAMP

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006879	cellular iron ion homeostasis	IEA	--
GO:0006955	immune response	TAS	11113131
GO:0031640	killing of cells of another organism	IEA	--
GO:0042742	defense response to bacterium	IEA	--
GO:0050832	defense response to fungus	IEA	--

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HAMP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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HAMP for compounds About GeneDecksing

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HAMP
10/73 Novoseek chemical compound relationships for HAMP gene (see all 73 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
iron	100.00	1535	17488680 (11), 17720947 (9), 12637325 (9), 19740974 (8) (see all 100)
hepc	27.84	20	12183449 (9), 11113132 (4), 16154838 (3), 12729891 (3) (see all 5)
ferric pyrophosphate	3.59	2	19740974 (2)
gadolinium chloride	2.72	3	19721414 (2), 19008338 (1)
interleukin 1	2.59	1	19608676 (1)
tocilizumab	2.49	2	17550864 (2)
turpentine	2.43	3	19533074 (1), 16928320 (1), 12370282 (1)
iron dextran	2.43	3	18690415 (1), 17619950 (1), 15902304 (1)
phenylhydrazine	2.36	3	16497104 (1), 15361505 (1), 12370282 (1)
ferrous sulfate	1.99	3	19740974 (2), 19144662 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HAMP)
		Applied Biosystems Silencer® siRNAs: NM_021175
		Origene 29mer shRNA kits in GFP-retroviral vector: HAMP Origene shRNA RFP: HAMP Origene basic RS shRNA: HAMP
		Sigma-Aldrich siRNA for HAMP Sigma-Aldrich shRNA for HAMP Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:

Search SABiosciences for microRNAs that regulate HAMP:

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_021175

Clones:

Origene GFP tagged cDNA clones in CMV expression vector: HAMP
Origene Myc/DDK tagged cDNA clones in CMV expression vector: HAMP
Origene untagged cDNA clones in CMV expression vector: HAMP

Primers:		Origene genome-wide validated SYBR primer pairs: HAMP
		SABiosciences RT2 qPCR Primer Assay for HAMP: PPH06152A

REFSEQ mRNAs for HAMP gene:

NM_021175.2

Additional cDNA sequence:

AF131292.1 AF147355.1 AF309489.1 AJ277280.1 AY358669.1 BC020612.1

3 DOTS entries:

DT.104663 DT.100018766 DT.100018767

20 AceView cDNA sequences:

AF147355 BX089371 AJ277280 NM_021175 BM719679 AI797446 BC020612 AF309489

AY358669 BM684049 CB116625 AK096110 T48278 AF131292 T48277 BG562482

AI829866 AI937227 BU587812 BP346863

highest scoring ESTs for HAMP:

AI937227 AF131292 AF309489 AI797446 AI829866 AJ277280 AY358669 BC020612 BG562482 BG568102

Unigene Cluster for HAMP:

Hepcidin antimicrobial peptide

Hs.8821 [show with all ESTs]

Unigene Representative Sequence: DR004094

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000222304

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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HAMP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HAMP

¹ / ² / ³

3 probe-sets matching HAMP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56641_at²^{, 3}	U95-B	1	0.94	1.00	1.00	1.00	AI937227	1.00	1.00	1.00	1
220491_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021175	0.60	1.00	0.82	1
220491_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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HAMP for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: TTCCAGAGGC

SOURCE GeneReport for Unigene cluster: Hs.8821

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172

Tissue specificity: Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils,

salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine

Primers:		Origene genome-wide validated SYBR primer pairs: HAMP
		SABiosciences RT2 qPCR Primer Assay for HAMP: PPH06152A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for HAMP gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HAMP¹	--	hepcidin antimicrobial peptide	80.32(n) 71.08(a)	492281 NM_001007140.1 NP_001007141.1
chimpanzee (Pan troglodytes)	HAMP¹	--	hepcidin antimicrobial peptide	99.6(n) 98.81(a)	744861 XM_001158692.1 XP_001158692.1
cow (Bos taurus)	HAMP¹	--	hepcidin antimicrobial peptide	78.05(n) 70.73(a)	512301 XM_589792.3 XP_589792.2
mouse (Mus musculus)	Hamp⁵	7 (11.00 cM)	hepcidin antimicrobial peptide	--	BC021587

About this table Species with no ortholog for HAMP

ENSEMBL Gene Tree for HAMP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/22 NCBI SNPs in HAMP are shown (see all 22 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1882695^1,2	C,F,A,H	32280145(+)	`ACACAA/GTCACG`	1	--	ng5¹ tfbs³		4	NA EA WA	212
	rs10421768^1,2	C,F,A	32281527(+)	`ACACCA/GCGTGC`	1	--	ng5¹ tfbs³		13	NS EA NA WA	966
	rs10414846^1,2	C,F,A	32281099(+)	`ATGTAC/TTCATC`	1	--	ng5¹		13	NS EA NA	922
--	rs66868858^1,2	C,F	32280478(+)	`TGGGCC/TGTGTG`	1	--	ng5¹		3	NA EA WA	210
	rs3817623^1,2	C,F	32281774(+)	`AGGGGG/TAACTT`	1	--	ng5¹ trp³		5	EA NS	1918
--	rs75448148^1,2	C,F	32280251(+)	`GGAGCC/TTCCCA`	1	--	ng5¹		2	EA WA	138
--	rs75714555^1,2	F	32280356(+)	`TTCCTC/TGACAA`	1	--	ng5¹		1	WA	50
	rs7251432^1,2	C,F,A,H	35775441(+)	`catccA/Gggcag`	1	--	int¹		24	NS EA WA NA MN	2665
--	rs11670019^1,2	C,F,H	32283024(+)	`ctcagC/Tgtccc`	1	--	int¹		1	NA	4
--	rs55863037^1,2	C,F	35775395(+)	`TTGAGG/AGGCAA`	1	--	int¹		8	MN NA EA WA	618

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HapMap Linkage Disequilibrium images for HAMP (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HAMP
1 CNV: 4078

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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HAMP for disorders About GeneDecksing

OMIM: 606464 disorders: 613313

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172

Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:602390]; also known as juvenile

hemochromatosis (JH). HFE2B is an early-onset autosomal recessive disorder due to severe iron overload resulting in

hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of

30. It is the consequence of intestinal iron hyperabsorption associated with macrophages that do not load iron

10/149 Novoseek disease relationships for HAMP gene (see all 149 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
anemia	100.00	227	18519751 (5), 19857675 (4), 19250447 (4), 18676162 (4) (see all 100)
hemochromatosis	100.00	133	17724144 (4), 16103673 (4), 19625109 (3), 19286879 (3) (see all 97)
juvenile hemochromatosis	100.00	40	17229647 (2), 15811010 (2), 15099344 (2), 12915468 (2) (see all 35)
iron overload	100.00	185	14770366 (5), 17488680 (4), 17098454 (4), 20045050 (3) (see all 100)
hereditary hemochromatosis	100.00	86	18164223 (3), 12637325 (3), 12547226 (3), 19571663 (2) (see all 71)
inflammation	77.22	196	16254410 (5), 15793843 (4), 12663437 (4), 20030521 (3) (see all 100)
deficiency; iron	59.66	57	19715836 (4), 19907147 (2), 19228364 (2), 19107209 (2) (see all 50)
iron disorder	43.74	17	19555735 (2), 17124036 (2), 19907144 (1), 19528880 (1) (see all 15)
anemia deficiency iron	24.87	28	19107209 (7), 19863534 (3), 17720947 (2), 20090120 (1) (see all 19)
beta-thalassemia	22.40	29	16939499 (6), 19059700 (4), 16755567 (4), 17488680 (3) (see all 14)

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GeneTests: HAMP

Juvenile Hemochromatosis

Human Gene Mutation Database: HAMP
Genetic Association Database: HAMP
Human Genome Epidemiology Navigator: HAMP (12 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/373 PubMed articles for HAMP gene (see all 373 ):

HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype. (PubMed id 14670915)^{1, 3, 4, 6} Jacolot S.... Ferec C. (2004)
LEAP-1, a novel highly disulfide-bonded human peptide exhibits antimicrobial activity. (PubMed id 11034317)^{2, 3, 4} Krause A.... Adermann K. (2000)
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. (PubMed id 11113132)^{1, 2, 3} Pigeon C....Loreal O. (2001)
Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R). (PubMed id 14630809)^{1, 3, 4} Roetto A.... Camaschella C. (2004)
Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. (PubMed id 12915468)^{1, 3, 4} Merryweather-Clarke A.T....Robson K.J. (2003)
The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. (PubMed id 12138110)^{1, 3, 4} Hunter H.N.... Vogel H.J. (2002)
Chemical synthesis of beta-defensins and LEAP-1/hepcidin. (PubMed id 12010514)^{1, 3, 4} Kluever E.... Adermann K. (2002)
Hepcidin: a urinary antimicrobial peptide synthesized in the liver. (PubMed id 11113131)^{1, 3, 4} Park C.H.... Ganz T. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57817	HGNC: 15598	AceView: HAMP	Ensembl:ENSG00000105697	euGenes: HUgn57817
ECgene: HAMP	H-InvDB: HAMP

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/HAMP
Wikipedia	http://en.wikipedia.org/wiki/Hepcidin

Intellectual Property for HAMP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for HAMP gene:

Search GeneIP for patents involving HAMP

GeneCards and IP:

Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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Products for HAMP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HAMP		Antibodies for HAMP
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HAMP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		Browse ELISAs at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HAMP)
	Antibodies (HAMP)
	Chimera RNAi (HAMP)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Tagged/untagged cDNA clones
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	Purified proteins from HEK293T cells
	Western blot validated antibodies
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GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

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Category			ACSF3 acyl-CoA synthetase family member 3
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

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HAMP Gene

protein-coding GIFtS: 53

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congenital dyserythropoietic anemia type i
myelofibrosis
h pylori infection
multiple myeloma stage iii
colitis ulcerative
end organ damage
major; thalassemia
hemolysis intravascular
atherosclerosis
nonsense mutation
hemochromatosis, type 3
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preterm infant
hepatic siderosis
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atresia biliary
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epo resistant anemia
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aceruloplasminemia
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hypoxic
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cellular stress
pyruvate kinase deficiency
hereditary hemochromatosis
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cholestasis
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anemia chronic disease
shock
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biliary cirrhosis
tuberculosis
renal impairment
sickle cell disease
failure liver
anemia
morbid obesities
prostate cancer
innate immune response
carcinoma hepatocellular
acute proctitis
deficiency; iron
cardiovascular disease
steatosis
alcohol; liver
disease; heart
chronic inflammatory disease
multicentric castleman disease
mycobacterial infection
psychological stress
bacterial infection
coxsackievirus
carcinoma; renal cell
obese
disease; inflammatory bowel
schnitzler syndrome
intermedia thalassemia
combined immunodeficiencies
chronic hepatitis c
atherosclerotic cardiovascular disease
iron disorder
uremia
CKD
mitochondrial damage
meningioma
polycythemia vera
insulin resistance
chronic infection
nephropathies
infection parasitic
vitamin a deficiencies
PCT
hemochromatosis
anemia, severe
infectious
obstructive sleep apnea
iron overload
ineffective erythropoiesis
chronic liver disease
genetic disorder
deficiency anemias, excluding iron
hemochromatosis, autosomal dominant
acute anemia
arthritis

Advanced Search (alpha)

HAMP Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor HAMP gene

Summariesfor HAMP gene

Genomic Viewsfor HAMP gene

Proteinsfor HAMP gene

Protein Domains/Familiesfor HAMP gene

Gene Functionfor HAMP gene

Pathways & Interactionsfor HAMP gene

Drugs & Compoundsfor HAMP gene

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Expression for HAMP gene

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Genomic Variantsfor HAMP gene

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Medical Newsfor HAMP gene

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Search for HAMP gene

Genome Databases showing HAMP gene

Other Databases showing HAMP gene

Specialized Databases showing HAMP gene

Intellectual Propertyfor HAMP gene

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Aliases &
Descriptions
for HAMP gene

Summaries
for HAMP gene

Genomic Views
for HAMP gene

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Protein Domains/
Families
for HAMP gene

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for HAMP gene

Expression
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