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HAMP Gene

protein-coding   GIFtS: 56
GCID: GC19P035955

Hepcidin Antimicrobial Peptide

  See HAMP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 8

Aliases
Hepcidin Antimicrobial Peptide1 2     PLTR2 3
HEPC2 3 5     HFE2B2 5
LEAP12 3 5     hepcidin2
Liver-Expressed Antimicrobial Peptide 12 3     LEAP-13
Putative Liver Tumor Regressor2 3     

External Ids:    HGNC: 155981   Entrez Gene: 578172   Ensembl: ENSG000001056977   OMIM: 6064645   UniProtKB: P811723   
ORGUL members:         
H-InvDB12: HIT000071428    

Export aliases for HAMP gene to outside databases

Previous GC identifers: GC19P036390 GC19P036222 GC19P040447 GC19P040465 GC19P035773 GC19P032282 GC19P035777


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HAMP Gene:
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the
regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is
post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are
rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides
exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile
hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and
endocrine failure. (provided by RefSeq, Jul 2008)

GeneCards Summary for HAMP Gene:
HAMP (hepcidin antimicrobial peptide) is a protein-coding gene. Diseases associated with HAMP include hemochromatosis, type 2b, and hamp-related juvenile hemochromatosis. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172
Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be
required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By
similarity)
Function: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis,
S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against
P.aeruginosa

Gene Wiki entry for HAMP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the HAMP gene promoter:
         COUP-TF1   COUP-TF   p300   COUP   STAT3   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAMP promoter sequence
   Search Chromatin IP Primers for HAMP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HAMP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

HAMP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAMP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035955:  view genomic region     (about GC identifiers)

Start:
35,771,619 bp from pter      End:
35,776,046 bp from pter
Size:
4,428 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172 (See protein sequence)
Recommended Name: Hepcidin precursor  
Size: 84 amino acids; 9408 Da
Mass spectrometry: Mass=2789.8; Method=MALDI; Range=60-84; Source=PubMed:11034317;
4 PDB 3D structures from and Proteopedia for HAMP:
1M4E (3D)        1M4F (3D)        2KEF (3D)        3H0T (3D)    
Secondary accessions: Q1HE14 Q9BY68

Explore the universe of human proteins at neXtProt for HAMP: NX_P81172

Explore proteomics data for HAMP at MOPED


See HAMP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_066998.1  
ENSEMBL proteins: 
 ENSP00000471894   ENSP00000222304  

HAMP Human Recombinant Protein Products:

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Novus Biologicals HAMP Lysate
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HAMP Assay Products:

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Search eBioscience for ELISAs for HAMP 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR010500 Hepcidin

Graphical View of Domain Structure for InterPro Entry P81172

ProtoNet protein and cluster: P81172

1 Blocks protein domain: IPB010500 Hepcidin

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172
Similarity: Belongs to the hepcidin family


Find genes that share domains with HAMP           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HEPC_HUMAN, P81172
Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be
required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By
similarity)
Function: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis,
S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against
P.aeruginosa

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity IEA--
     
Find genes that share ontologies with HAMP           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for HAMP:
 Decreased Hepatitis C virus re 

     5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hamp):
 growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

Find genes that share phenotypes with HAMP           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for HAMP: Hamptm1Lex Hamptm1Svl

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HAMP
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HAMP

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HAMP
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HAMP

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat HAMP

Gene Editing
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GenScript: all cDNA clones in your preferred vector: HAMP (NM_021175)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAMP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAMP

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eBioscience FlowRNA Probe Sets ( VA4-11258) for HAMP 


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HEPC_HUMAN, P81172: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
plasma membrane2
endoplasmic reticulum1
endosome1
mitochondrion1
nucleus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS11034317
GO:0005737cytoplasm ----
GO:0045179apical cortex IEA--

Find genes that share ontologies with HAMP           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for HAMP About    
See pathways by source

SuperPathContained pathways About
1Iron metabolism in placenta
Iron metabolism in placenta


1 BioSystems Pathway for HAMP
    Iron metabolism in placenta


    Pathway & Disease-focused RT2 Profiler PCR Array including HAMP: 
          Cardiotoxicity in human mouse rat

Interactions:

    GeneGlobe Interaction Network for HAMP

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for HAMP (P811723 ENSP000002223044) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SLC40A1Q9NP593, ENSP000002610244I2D: score=2 STRING: ENSP00000261024
CKAP4ENSP000003672654STRING: ENSP00000367265
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006879cellular iron ion homeostasis IEA--
GO:0006955immune response TAS11113131
GO:0031640killing of cells of other organism IEA--
GO:0042742defense response to bacterium IEA--
GO:0050832defense response to fungus IEA--

Find genes that share ontologies with HAMP           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HAMP (HEPC)

1 HMDB Compound for HAMP    About this table
CompoundSynonyms CAS #PubMed Ids
IronArmco iron (see all 19)7439-89-6--

5 Novoseek inferred chemical compound relationships for HAMP gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
iron 84.2 142 16103673 (6), 16629180 (4), 12606179 (4), 15725899 (4) (see all 66)
anti-fungal 4.44 3 16629180 (1), 12138110 (1)
ethanol 0 1 16737972 (1)
oxygen 0 1 16460831 (1)
creatinine 0 2 19857675 (1)



Find genes that share compounds with HAMP           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HAMP gene: 
NM_021175.2  

Unigene Cluster for HAMP:

Hepcidin antimicrobial peptide
Hs.8821  [show with all ESTs]
Unigene Representative Sequence: DR004094
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000598398 ENST00000222304(uc002nyw.3) ENST00000593580
miRNA
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Search for qRT-PCR Assays for microRNAs that regulate HAMP
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HAMP
Predesigned siRNA for gene silencing in human, mouse, rat HAMP
Clone
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OriGene clones in human, mouse for HAMP (see all 6)
OriGene ORF clones in mouse, rat for HAMP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HAMP (NM_021175)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HAMP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HAMP
Primer
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OriGene qPCR primer pairs and template standards for HAMP
OriGene qSTAR qPCR primer pairs in human, mouse for HAMP
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HAMP
  QuantiTect SYBR Green Assays in human, mouse, rat HAMP
  QuantiFast Probe-based Assays in human, mouse, rat HAMP
Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA4-11258) for HAMP 

Additional mRNA sequence: 

AF131292.1 AF147355.1 AF309489.1 AJ277280.1 AY358669.1 BC020612.1 

3 DOTS entries:

DT.104663  DT.100018766  DT.100018767 

20 AceView cDNA sequences:

BM684049 AF309489 BX089371 AY358669 BM719679 AI797446 AJ277280 AF147355 
NM_021175 BC020612 AF131292 T48278 T48277 AK096110 CB116625 BG562482 
AI829866 AI937227 BU587812 BP346863 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HAMP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCCAGAGGC
HAMP Expression
About this image


HAMP expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Pancreas (Endocrine System)
         Islets of Langerhans
 
 Heart (Cardiovascular System)
 
 Liver (Hepatobiliary System)
HAMP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HAMP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.8821

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172
Tissue specificity: Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung,
tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine

    Pathway & Disease-focused RT2 Profiler PCR Array including HAMP: 
          Cardiotoxicity in human mouse rat

Primer
Products:
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OriGene qSTAR qPCR primer pairs in human, mouse for HAMP
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HAMP
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QuantiFast Probe-based Assays in human, mouse, rat HAMP
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAMP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for HAMP gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hamp5 hepcidin antimicrobial peptide   --   7 (19.27 cM) 30942371 


ENSEMBL Gene Tree for HAMP (if available)
TreeFam Gene Tree for HAMP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HAMP (see all 124)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1048946961,2,,4
C,FHemochromatosis 2B (HFE2B)4 pathogenic135934878(+) CTGCGG/ACTGCT 2 /D /G mis12Minor allele frequency- A:0.00NA EU 5875
VAR_0425134
Hemochromatosis 2B (HFE2B)4--see VAR_0425132 C R mis40--------
VAR_0425144
Hemochromatosis 2B (HFE2B)4--see VAR_0425142 C Y mis40--------
VAR_0425124
Hemochromatosis 2B (HFE2B)4--see VAR_0425122 R G mis40--------
rs1048946951,2
Cpathogenic135934832(+) AGAGGC/TGAAGG 2 R * stg10--------
rs3732140161,2
C--35775509(+) GGGAG-/TTTTTT 1 -- int10--------
rs18826951,2
C,F,A,H--35930491(+) ACACAA/GTCACG 1 -- us2k1 tfbs38Minor allele frequency- G:0.22WA NA CSA EA 368
rs1478168321,2
--35930540(+) CACAGC/GCAAGT 1 -- us2k10--------
rs754481481,2
F--35930597(+) GGAGCC/TTCCCA 1 -- us2k12Minor allele frequency- T:0.07WA EA 238
rs757145551,2
C,F--35930702(+) TTCCTC/TGACAA 1 -- us2k12Minor allele frequency- T:0.07CSA WA 120

HapMap Linkage Disequilibrium report for HAMP (35771619 - 35776046 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for HAMP:    About this table    
Variant IDTypeSubtypePubMed ID
dgv3850n71CNV Loss21882294
nsv510765CNV Loss20534489
nsv911618CNV Loss21882294
dgv1080e1CNV Complex17122850

Human Gene Mutation Database (HGMD): HAMP
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HAMP
DNA2.0 Custom Variant and Variant Library Synthesis for HAMP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606464   
OMIM disorders: 613313  
UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172
  • Hemochromatosis 2B (HFE2B) [MIM:613313]: A juvenile form of hemochromatosis, a disorder of iron
    metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin
    pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis
    at presentation are hypogonadism and cardiomyopathy. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 10 diseases for HAMP:    
    About MalaCards
    hemochromatosis, type 2b    hamp-related juvenile hemochromatosis    hemochromatosis type 2    hemochromatosis, type 2a
    aceruloplasminemia    juvenile hereditary hemochromatosis    hemochromatosis    hemoglobinopathy
    congenital dyserythropoietic anemia type i    porphyria cutanea tarda

    8 diseases from the University of Copenhagen DISEASES database for HAMP:
    Hemochromatosis     Anemia     Nutrition disease     Thalassemia
    Aceruloplasminemia     Liver disease     Kidney disease     Hepatitis C

    Find genes that share disorders with HAMP           About GenesLikeMe

    7 Novoseek inferred disease relationships for HAMP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hemochromatosis, juvenile 93.8 15 15099344 (1), 16234038 (1), 16493621 (1), 18762941 (1) (see all 14)
    iron overload 90.9 23 12915468 (2), 12183449 (2), 16103673 (2), 18809758 (2) (see all 16)
    hemochromatosis 87.4 27 16103673 (4), 16234038 (1), 19625109 (1), 15198949 (1) (see all 12)
    hereditary hemochromatosis 86.8 6 15024747 (2), 14670915 (1), 16103673 (1), 19342478 (1) (see all 5)
    anemia 54.1 6 16838333 (2), 18544472 (1), 19541813 (1), 20019408 (1) (see all 5)
    inflammation 39.9 7 18775801 (1), 19478464 (1), 15315977 (1), 17218383 (1) (see all 5)
    response acute phase 29.8 2 15725899 (1), 15973703 (1)

    GeneTests: HAMP
    GeneReviews: HAMP
    Genetic Association Database (GAD): HAMP
    Human Genome Epidemiology (HuGE) Navigator: HAMP (17 documents)

    Export disorders for HAMP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HAMP gene, integrated from 10 sources (see all 353):
    (articles sorted by number of sources associating them with HAMP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype. (PubMed id 14670915)1, 2, 4, 9 Jacolot S.... Ferec C. (Blood 2004)
    2. LEAP-1, a novel highly disulfide-bonded human peptide exhibits antimicrobial activity. (PubMed id 11034317)1, 2, 3 Krause A.... Adermann K. (FEBS Lett. 2000)
    3. Mutations in HAMP and HJV genes and their impact on expression of clinical hemochromatosis in a cohort of 100 Spanish patients homozygous for the C282Y mutation of HFE gene. (PubMed id 19214511)1, 4, 9 AltA"s A....Baiget M. (Ann. Hematol. 2009)
    4. Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. (PubMed id 12915468)1, 2, 9 Merryweather-Clarke A.T....Robson K.J. (Hum. Mol. Genet. 2003)
    5. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. (PubMed id 12138110)1, 2, 9 Hunter H.N.... Vogel H.J. (J. Biol. Chem. 2002)
    6. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. (PubMed id 11113132)1, 3, 9 Pigeon C....LorAcal O. (J. Biol. Chem. 2001)
    7. Association of hepcidin promoter c.-582 A&gt;G variant and iron overload in thalassemia major. (PubMed id 19734422)1, 4, 9 Andreani M....Grammatico P. (Haematologica 2009)
    8. Non-classical hereditary hemochromatosis in Portugal: novel mutations identified in iron metabolism-related genes. (PubMed id 18762941)1, 4, 9 Mendes A.I....Faustino P. (Ann. Hematol. 2009)
    9. Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk. (PubMed id 19711434)1, 4, 9 Dorak M.T....Hall A.G. (amp 2009)
    10. Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance. (PubMed id 17847004)1, 4, 9 Milet J....Mosser J. (Am. J. Hum. Genet. 2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57817 HGNC: 15598 AceView: HAMP Ensembl:ENSG00000105697 euGenes: HUgn57817
    ECgene: HAMP H-InvDB: HAMP

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HAMP Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=HAMP[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Hepcidin

    (Patent information from GeneIP,
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