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HAMP Gene

protein-coding GIFtS: 57

GC19P040465

hepcidin antimicrobial peptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
HEPC ^¹, ², ³, ⁵
HEPCIDIN ^²
HFE2 ^⁵
HFE2B ^¹, ²
LEAP-1 ^¹, ², ³
LEAP1 ^¹, ², ³, ⁵
PLTR ^², ³

Descriptions
Liver-expressed antimicrobial peptide ^², ³
Putative liver tumor regressor ^², ³
hepcidin antimicrobial peptide ^²

External Ids
HGNC: 15598¹
Entrez Gene: 57817²
UniProtKB: P81172³
Ensembl: ENSG00000105697⁷

Search outside databases for aliases for HAMP gene

Previous GC identifers: GC19P036390 GC19P036222 GC19P040447

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HAMP:

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is

necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption.

The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino

acids, and these active peptides are rich in cysteines, which form intramolecular bonds that

stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in

this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused

by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.

[provided by RefSeq]

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172

Function: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against

S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans.

No activity against P.aeruginosa

Gene Wiki entry for HAMP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HAMP gene

Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.1

HAMP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P040465: (about GC identifiers)

Start:	40,465,250 bp from pter
End:	40,467,886 bp from pter
Size:	2,637 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172 (See protein sequence)

Recommended Name: Hepcidin precursor

Size: 84 amino acids; 9408 Da

Subcellular location: Secreted

Mass spectrometry: Mass=2789.8; Method=MALDI; Range=60-84; Source=PubMed:11034317;

PDB structure from and Proteopedia :

1M4E (3D)

1M4F (3D)

Secondary accessions: Q1HE14 Q9BY68

REFSEQ proteins: NP_066998.1

ENSEMBL proteins:

ENSP00000222304

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Hepcidin-25)
	Human Recombinant Proteins from Abnova (HAMP)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	11034317

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Antibodies for HAMP:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HAMP
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Hepcidin-25), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HAMP)
	Novus Biologicals Antibodies for HAMP

Assays for HAMP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P81172

ProtoNet protein and cluster: P81172

1 Blocks protein family: IPB010500 Hepcidin

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172

Similarity: Belongs to the hepcidin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAMP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HAMP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021175

Applied Biosystems Silencer® siRNAs for HAMP

Sigma-Aldrich siRNA for HAMP

Sigma-Aldrich shRNA for HAMP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HAMP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_021175
Myc/DDK tagged cDNA clone in CMV expression vector: NM_021175
untagged cDNA clone in CMV expression vector: NM_021175

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021175

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172

Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis.

Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron

storage in macrophages (By similarity)

Function: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against

S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans.

No activity against P.aeruginosa

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hamp):

growth/size

hematopoietic system

homeostasis/metabolism

immune system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for HAMP (Your Favorite Gene powered by Ingenuity)

Acute Phase Response Signaling

GeneDecks HAMP for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for HAMP

5/39 Interacting proteins for HAMP (ENSP00000222304³) via UniProtKB, MINT, and/or STRING (see all 39 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC40A1	ENSP00000261024³	STRING (score=.997)
HFE	ENSP00000311698³	STRING (score=.993)
HFE2	ENSP00000337014³	STRING (score=.993)
TF	ENSP00000264998³	STRING (score=.993)
TFR2	ENSP00000223051³	STRING (score=.992)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	IEA	--
GO:0006879	cellular iron ion homeostasis	IEA	--
GO:0006955	immune response	TAS	11113131
GO:0042742	defense response to bacterium	IEA	--
GO:0050832	defense response to fungus	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HAMP
3 Novoseek chemical compound relationships for HAMP gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
iron	82.92	119	16103673 (6), 16629180 (4), 12606179 (4), 15725899 (4) (see all 53)
oxygen	0.00	1	16460831 (1)
ethanol	0.00	1	16737972 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HAMP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HAMP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021175

Sigma-Aldrich siRNA for HAMP

Sigma-Aldrich shRNA for HAMP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_021175

REFSEQ mRNAs for HAMP gene:

NM_021175.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_021175

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021175
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021175
                                 untagged cDNA clone in CMV expression vector: NM_021175

Additional cDNA sequence:

AF131292.1 AF147355.1 AF309489.1 AJ277280.1 AY358669.1 BC020612.1

3 DOTS entries:

DT.104663 DT.100018766 DT.100018767

20 AceView cDNA sequences:

AJ277280 AF309489 AF147355 AI797446 BM719679 AY358669 BC020612 BM684049

NM_021175 BX089371 T48277 T48278 AK096110 AF131292 CB116625 BG562482

AI937227 AI829866 BU587812 BP346863

highest scoring ESTs for HAMP:

AI937227 AF131292 AF309489 AI797446 AI829866 AJ277280 AY358669 BC020612 BG562482 BG568102

Unigene Cluster for HAMP:

Hepcidin antimicrobial peptide

Hs.8821 [show with all ESTs]

Unigene Representative Sequence: DR004094

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000222304

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HAMP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HAMP

¹ / ² / ³

3 probe-sets matching HAMP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56641_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AI937227	1.00	1.00	1.00	1
220491_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021175	0.60	1.00	0.82	1
220491_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HAMP for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTCCAGAGGC

SOURCE GeneReport for Unigene cluster: Hs.8821
UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172
Tissue specificity: Highest expression in liver and to a lesser extent in heart and brain. Low
levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland.
Secreted into the urine

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HAMP gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HAMP¹	--	hepcidin antimicrobial peptide	80.32(n) 71.08(a)	492281 NM_001007140.1 NP_001007141.1
chimpanzee (Pan troglodytes)	HAMP¹	--	hepcidin antimicrobial peptide	99.6(n) 98.81(a)	744861 XM_001158692.1 XP_001158692.1
cow (Bos taurus)	HAMP¹	--	hepcidin antimicrobial peptide	78.05(n) 70.73(a)	512301 XM_589792.3 XP_589792.2
mouse (Mus musculus)	Hamp⁵	7 (11.00 cM)	hepcidin antimicrobial peptide	--	BC021587

About this table Species with no ortholog for HAMP

ENSEMBL Gene Tree for HAMP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/18 NCBI SNPs in HAMP are shown (see all 18 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10421768^1,2	A,C,F,H	40464739(+)	`ACACCA/GCGTGC`	1	--	ng5¹ tfbs³		8		EU EA WA	832
	rs10414846^1,2	A,C,F,H	40464311(+)	`ATGTAC/TTCATC`	1	--	ng5¹		8		EU EA WA	838
	rs3817623^1,2	F,H	40464986(+)	`AGGGGG/TAACTT`	1	--	ng5¹ trp³		5		EA EU WA	1918
--	rs1882695^1,2	A,C	40463357(+)	`ACACAA/GTCACG`	1	--	ng5¹ tfbs³		0	--	--	--	--
	rs7251432^1,2	A,C,F,H	40467281(+)	`catccA/Gggcag`	1	--	int¹		7		EU EA WA NA	560
	rs8101606^1,2	C,F,H	40466396(+)	`GGACAA/Cgccag`	1	--	int¹		12		EU EA WA NA	1190
	rs2293689^1,2	C,F,H	40467466(+)	`GTTGCC/TGGGAG`	1	--	int¹		8		EA NA EU WA	2014
--	rs10409503^1,2	A,C	40466666(+)	`ccgagC/Tagctg`	1	--	int¹		0	--	--	--	--
	rs12608868^1,2	H	40465937(+)	`GACAGT/CGGGGA`	1	--	int¹		4		EU EA WA	418
--	rs10416795^1,2	H	40467105(+)	`atcgcT/Ctgagc`	1	--	int¹		4		EU EA WA	410

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HapMap Linkage Disequilibrium images for HAMP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606464 disorders: 602390 602390

UniProtKB/Swiss-Prot: HEPC_HUMAN, P81172

Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:602390]; also called

juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe

iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and

cardiomyopathy, occurring typically before age of 30. It is the consequence of intestinal iron

hyperabsorption associated with macrophages that do not load iron

7 Novoseek disease relationships for HAMP gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hemochromatosis, juvenile	94.34	14	15099344 (1), 16234038 (1), 16493621 (1), 18762941 (1) (see all 13)
iron overload	91.23	22	12915468 (2), 12183449 (2), 16103673 (2), 18809758 (2) (see all 15)
hemochromatosis	87.36	25	16103673 (4), 16234038 (1), 15198949 (1), 15701302 (1) (see all 10)
hereditary hemochromatosis	84.81	5	15024747 (2), 14670915 (1), 16103673 (1), 17373275 (1)
anemia	51.99	4	16838333 (2), 18544472 (1), 17218383 (1)
response acute phase	34.00	2	15725899 (1), 15973703 (1)
inflammation	30.24	4	18775801 (1), 15315977 (1), 17218383 (1), 18936232 (1)

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GeneTests: HAMP

Juvenile Hemochromatosis

Human Gene Mutation Database: HAMP
Genetic Association Database: HAMP
Human Genome Epidemiology Navigator: HAMP (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/178 PubMed articles for HAMP gene (see all 178 ):

HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype. (PubMed id 14670915)^{1, 3, 4, 6} Jacolot S.... Ferec C. (2004)
LEAP-1, a novel highly disulfide-bonded human peptide exhibits antimicrobial activity. (PubMed id 11034317)^{2, 3, 4} Krause A.... Adermann K. (2000)
Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. (PubMed id 12915468)^{1, 3, 4} Merryweather-Clarke A.T....Robson K.J. (2003)
The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. (PubMed id 12138110)^{1, 3, 4} Hunter H.N.... Vogel H.J. (2002)
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. (PubMed id 11113132)^{1, 2, 3} Pigeon C....Loreal O. (2001)
Hepcidin: a urinary antimicrobial peptide synthesized in the liver. (PubMed id 11113131)^{1, 3, 4} Park C.H.... Ganz T. (2001)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R). (PubMed id 14630809)^{3, 4} Roetto A.... Camaschella C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57817	HGNC: 15598	AceView: HAMP	Ensembl:ENSG00000105697	euGenes: HUgn57817
ECgene: HAMP	H-InvDB: HAMP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=HAMP
Wikipedia	http://en.wikipedia.org/wiki/Hepcidin

Licensable Technologies for HAMP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for HAMP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HAMP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HAMP		Antibodies for HAMP
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HAMP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HAMP)
	Antibodies (HAMP)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Hepcidin-25)
	Antibodies (Hepcidin-25)

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Search Tocris compounds for HAMP

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HAMP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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HAMP Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for HAMP

Summaries
for HAMP

Genomic Location
for HAMP

Proteins
for HAMP

Protein Domains/
Families
for HAMP

Gene Function
for HAMP

Pathways & Interactions
for HAMP

Drugs & Compounds
for HAMP

Transcripts
for HAMP

Expression
for HAMP

Orthologs
for HAMP

Paralogs
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SNPs/Variants
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Disorders & Mutations
for HAMP

Medical News
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Publications
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Genome Databases showing HAMP

Other Databases showing HAMP

Specialized Databases showing HAMP

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HAMP Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor HAMP

Summariesfor HAMP

Genomic Locationfor HAMP

Proteinsfor HAMP

Protein Domains/Familiesfor HAMP

Gene Functionfor HAMP

Pathways & Interactionsfor HAMP

Drugs & Compoundsfor HAMP

Transcriptsfor HAMP

Expression for HAMP

Orthologsfor HAMP

Paralogsfor HAMP

SNPs/Variantsfor HAMP

Disorders & Mutationsfor HAMP

Medical Newsfor HAMP

Publicationsfor HAMP

Search for HAMP

Genome Databases showing HAMP

Other Databases showing HAMP

Specialized Databases showing HAMP

Licensable Technologiesfor HAMP

Servicesfor HAMP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HAMP

Summaries
for HAMP

Genomic Location
for HAMP

Proteins
for HAMP

Protein Domains/
Families
for HAMP

Gene Function
for HAMP

Pathways & Interactions
for HAMP

Drugs & Compounds
for HAMP

Transcripts
for HAMP

Expression
for HAMP

Orthologs
for HAMP

Paralogs
for HAMP

SNPs/Variants
for HAMP

Disorders & Mutations
for HAMP

Medical News
for HAMP

Publications
for HAMP

Licensable Technologies
for HAMP

Services
for HAMP