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Aliases & Descriptions for HAL
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 4.3.1.3 3 | | HIS 2, 3 | | HSTD 2, 5 | | Histidase 3 | | histidase 2 |
| | | Descriptions |
|---|
| histidine ammonia-lyase 2 |
|
| | Search outside databases for aliases for HAL genePrevious GC identifers: GC12M095787 GC12M096730 GC12M096300 |
Summaries for HAL(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HAL: Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids [provided by RefSeq]
|
Genomic Location for HAL
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HAL gene 
Entrez Gene cytogenetic band: 12q22-q24.1 Ensembl cytogenetic band: 12q23.1 HGNC cytogenetic band: 12q22-q24.1HAL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M094869:
(about GC identifiers)
Start:
|
94,891,273 bp from pter |
End:
|
94,914,202 bp from pter |
Size:
|
22,930 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000012.10 NT_019546.15
| Proteins for HAL
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HUTH_HUMAN, P42357 (See
protein sequence)Recommended Name: Histidine ammonia-lyase Size: 657 amino acids; 72698 Da
Secondary accessions: Q4VB92Post-translational modifications:
Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002099.1
ENSEMBL proteins: ENSP00000261208
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HAL: Assays for HAL: | Protein
Domains/ Families for HAL(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P42357
ProtoNet protein and cluster: P42357 UniProtKB/Swiss-Prot: HUTH_HUMAN, P42357Similarity: Belongs to the PAL/histidase family | Gene Function for HAL
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002108
Applied Biosystems Silencer® siRNAs for HAL
Sigma-Aldrich siRNA for HAL  Sigma-Aldrich shRNA for HAL  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002108                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002108                                  untagged cDNA clone in CMV expression vector: NM_002108 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002108
UniProtKB/Swiss-Prot: HUTH_HUMAN, P42357Catalytic activity: L-histidine = urocanate + NH(3)Enzyme Number (IUBMB): EC 4.3.1.3 Genatlas biochemistry entry for HAL:histidine ammonia lyase (histidase),histidine catabolism2 MGI phenotypic alleles for Hal (no phenotypes)
3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004397 | histidine ammonia-lyase activity |
IEA | -- | | GO:0016211 | ammonia ligase activity |
IEA | -- | | GO:0016829 | lyase activity |
IEA | -- | About this table | Pathways & Interactions for HAL
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for HAL (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: HUTH_HUMAN, P42357Pathway: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/32 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006548 | histidine catabolic process |
IEA | -- | | GO:0009058 | biosynthetic process |
IEA | -- | About this table
|
Drugs & Compounds for HAL(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for HAL 8 Novoseek chemical compound relationships for HAL gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| urocanic acid |
90.58 |
13 |
1943682 (2), 18641401 (1), 15806399 (1), 8530107 (1) (see all 7) |
| histidinol-phosphate |
85.54 |
2 |
1537807 (1), 8507666 (1) |
| dehydroalanine |
85.39 |
3 |
1537807 (1), 1943682 (1), 12686130 (1) |
| histidine |
79.94 |
51 |
8507666 (4), 1902841 (3), 1618765 (3), 11457276 (2) (see all 25) |
| phenylalanine |
62.52 |
10 |
1537807 (1), 15906398 (1), 2124955 (1), 12686130 (1) (see all 6) |
| cinnamic acid |
57.43 |
2 |
17191848 (1), 8947915 (1) |
| hydrogen |
3.90 |
4 |
17191848 (1), 1902841 (1), 1618765 (1) |
| tyrosine |
0.00 |
3 |
2124955 (1), 17185227 (1) |
About this table
|
Transcripts for HAL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002108
Sigma-Aldrich siRNA for HAL  Sigma-Aldrich shRNA for HAL  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002108 REFSEQ mRNAs for HAL gene: NM_002108.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002108               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002108                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002108                                  untagged cDNA clone in CMV expression vector: NM_002108  Additional cDNA sequence: AK297004.1 AK298736.1 AK303544.1 BC096096.1 BC096097.3 BC096098.3 BC096099.1 D16626.1 6 DOTS entries: DT.453679 DT.40105879 DT.95162338 DT.99956019 DT.70102504 DT.115837 24/51 AceView cDNA sequences (see all 51
):CB156949 AV683598 BX089267 D16626 C01635 AA778922 NM_002108 AL596896 BU739014 CB153364 BX506683 N76272 CB161424 CB115673 N55360 BM713716 AL601504 BX643395 BX422319 AL597111 CB162549 AI249025 AL597387 AI248003
highest scoring ESTs for HAL:AL596896 AL597111 AL597387 AL601504 D16626 AI033058 AI140162 AI249025 AV655741 AV688965 Unigene Cluster for HAL: Histidine ammonia-lyase Hs.190783 [show with all ESTs]Unigene Representative Sequence: NM_002108
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for HAL
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 22a | · | 22b | |
| SP1: | |   | |   | |
| SP2: | |   | |   | |
| SP3: | |   | |   | |
| SP4: | |   | |   |
About this scheme
ECgene alternative splicing isoforms for HAL
1 Ensembl transcript including schematic representation: ENST00000261208
|
Expression for HAL
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HAL expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HAL
1 / 2 / 3 3 probe-sets matching HAL gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.190783
Expression variation in blood from EXPOLDB for HAL |
Orthologs for HAL
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HAL gene from 5/12 species (see all 12
)
About this table Species with no ortholog for HAL
ENSEMBL Gene Tree for HAL | Paralogs for HAL(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for HAL(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HAL (up to first 250kb)
|
Disorders & Mutations for HAL
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609457 disorders: 235800 UniProtKB/Swiss-Prot: HUTH_HUMAN, P42357
Defects in HAL are the cause of histidinemia [MIM:235800]. It is an autosomal recessive disease characterized by increased histidine and histamine as well as decreased urocanic acid in body fluids1 Novoseek disease relationship for HAL gene
About this table
Genatlas disease: HAL histidinemia Human Gene Mutation Database: HAL Genetic Association Database: HAL Human Genome Epidemiology Navigator: HAL (7 documents)
|
Medical News for HAL(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for HAL (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/42 PubMed articles for HAL gene (see all 42
):- Molecular cloning and structural characterization of the human histidase gene (HAL). (PubMed id 8530107)1, 3, 4 Suchi M.... Wada Y. (1995)
- Molecular cloning of a cDNA encoding human histidase. (PubMed id 7916645)1, 3, 4 Suchi M.... Takagi Y. (1993)
- Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene. (PubMed id 15806399)1, 3, 4 Kawai Y.... Suchi M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid. (PubMed id 18280705)1, 3 Eckhart L....Tschachler E. (2008)
- Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells. (PubMed id 15741241)1, 3 Aleman G....Torres N. (2005)
- Localization of histidase to human chromosome region 12q22----q24.1 and mouse chromosome region 10C2----D1. (PubMed id 2055114)1, 3 Taylor R.G....McInnes R.R. (1991)
- A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions. (PubMed id 18641401)1, 3 Welsh M.M....Nelson H.H. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Association study of schizophrenia and the histidase gene. (PubMed id 9323322)6 Nobile M....Catalano M. (1997)
|
Search for HAL
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HAL
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HAL
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HAL(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| GeneReviews | http://www.genetests.org/query?gene=HAL |
|
| | | About This Section
| --
| Services for HAL(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HAL:

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Incremental update: 13 Oct 2009
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