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Aliases for HAGHL Gene

Aliases for HAGHL Gene

  • Hydroxyacylglutathione Hydrolase-Like 2 3 5
  • Hydroxyacyl Glutathione Hydrolase-Like 2
  • EC 3.1.2.- 4

External Ids for HAGHL Gene

Previous GeneCards Identifiers for HAGHL Gene

  • GC16U990171
  • GC16P000716
  • GC16P000717
  • GC16P000777
  • GC16P000701
  • GC16P000780
  • GC16P000781
  • GC16P000782
  • GC16P000789
  • GC16P000807
  • GC16P000832
  • GC16P000851
  • GC16P000835
  • GC16P000860
  • GC16P000877
  • GC16P000895

Summaries for HAGHL Gene

GeneCards Summary for HAGHL Gene

HAGHL (Hydroxyacylglutathione Hydrolase-Like) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and hydroxyacylglutathione hydrolase activity. An important paralog of this gene is HAGH.

UniProtKB/Swiss-Prot for HAGHL Gene

  • Hydrolase acting on ester bonds.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAGHL Gene

Genomics for HAGHL Gene

Regulatory Elements for HAGHL Gene

Enhancers for HAGHL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F000726 0.6 ENCODE 17.6 +0.9 887 3.5 HDGF ARNT SIN3A YBX1 ZNF2 ETS1 ZNF121 GTF3C2 GLIS2 ELK1 ENSG00000261505 ENSG00000260051 RHOT2 ENSG00000260954 HN1L JMJD8 WASH4P NARFL ENSG00000226890 HAGHL
GH16F000718 1.1 ENCODE 10.3 -6.2 -6173 3.6 PKNOX1 CREB3L1 SIN3A ZNF2 ZNF143 ZNF207 KLF13 SP3 MXD4 REST IFT140 NARFL ENSG00000269482 LOC105371038 JMJD8 HN1L TMEM204 CCDC154 ENSG00000262528 ENSG00000268836
GH16F000712 0.9 Ensembl ENCODE 6.4 -14.0 -13996 1.2 MLX ARID4B SIN3A ZNF2 GLIS2 KLF7 FOS KLF13 SP3 SP5 WFIKKN1 HAGHL ENSG00000259840 METRN
GH16F000329 1.1 FANTOM5 Ensembl ENCODE 1.3 -395.5 -395496 3.1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 GLIS2 ZNF263 SP3 MXD4 TMEM8A NHLRC4 MRPL28 ARHGDIG NME4 AXIN1 HAGHL PIR38678 GC16P000365
GH16F000725 0.2 ENCODE 0.8 -1.2 -1151 0.1 ZFHX2 GLIS2 ZNF692 POLR2A ZEB2 ZEB1 EGR2 HAGHL PIR42074
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HAGHL on UCSC Golden Path with GeneCards custom track

Promoters for HAGHL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502076 964 2601 HDGF ARNT SIN3A YBX1 ZNF2 ETS1 ZNF121 GTF3C2 GLIS2 ZNF143

Genomic Location for HAGHL Gene

Chromosome:
16
Start:
726,936 bp from pter
End:
735,525 bp from pter
Size:
8,590 bases
Orientation:
Plus strand

Genomic View for HAGHL Gene

Genes around HAGHL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HAGHL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HAGHL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAGHL Gene

Proteins for HAGHL Gene

  • Protein details for HAGHL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PII5-HAGHL_HUMAN
    Recommended name:
    Hydroxyacylglutathione hydrolase-like protein
    Protein Accession:
    Q6PII5
    Secondary Accessions:
    • A6NCC4
    • D3DU64
    • Q59FX8
    • Q96BZ3
    • Q96NR5
    • Q96S11
    • Q9BT45

    Protein attributes for HAGHL Gene

    Size:
    290 amino acids
    Molecular mass:
    31557 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK61250.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD92568.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92568.1; Type=Miscellaneous discrepancy; Note=Sequence of unknown origin at the C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAGHL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAGHL Gene

Post-translational modifications for HAGHL Gene

  • Ubiquitination at Lys 34
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HAGHL Gene

Domains & Families for HAGHL Gene

Protein Domains for HAGHL Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6PII5

UniProtKB/Swiss-Prot:

HAGHL_HUMAN :
  • Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Family:
  • Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
genes like me logo Genes that share domains with HAGHL: view

No data available for Gene Families for HAGHL Gene

Function for HAGHL Gene

Molecular function for HAGHL Gene

UniProtKB/Swiss-Prot Function:
Hydrolase acting on ester bonds.

Enzyme Numbers (IUBMB) for HAGHL Gene

Gene Ontology (GO) - Molecular Function for HAGHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HAGHL: view
genes like me logo Genes that share phenotypes with HAGHL: view

Animal Model Products

miRNA for HAGHL Gene

miRTarBase miRNAs that target HAGHL

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HAGHL Gene

Localization for HAGHL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAGHL Gene COMPARTMENTS Subcellular localization image for HAGHL gene
Compartment Confidence
cytosol 3
extracellular 3
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HAGHL Gene

Pathways & Interactions for HAGHL Gene

SuperPathways for HAGHL Gene

No Data Available

Gene Ontology (GO) - Biological Process for HAGHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA --
genes like me logo Genes that share ontologies with HAGHL: view

No data available for Pathways by source and SIGNOR curated interactions for HAGHL Gene

Drugs & Compounds for HAGHL Gene

(3) Drugs for HAGHL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Glutathione Approved Nutra 0
D-Lactic acid Experimental Pharma 0

(1) Additional Compounds for HAGHL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
S-Lactoylglutathione
  • (R)-S-lactoylglutathione
  • D-Lactoylglutathione
  • delta-Lactoylglutathione
  • N-(N-L-gamma-Glutamyl-S-(2-hydroxy-1-oxopropyl)-L-cysteinyl)-glycine
  • S-D-Lactoyl-glutathione
25138-66-3
genes like me logo Genes that share compounds with HAGHL: view

Transcripts for HAGHL Gene

Unigene Clusters for HAGHL Gene

Hydroxyacylglutathione hydrolase-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAGHL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ·
SP1: - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7: - - - - - - - - -
SP8: - - -
SP9: -
SP10: -
SP11:

ExUns: 9d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for HAGHL Gene

GeneLoc Exon Structure for
HAGHL
ECgene alternative splicing isoforms for
HAGHL

Expression for HAGHL Gene

mRNA expression in normal human tissues for HAGHL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAGHL Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HAGHL Gene



NURSA nuclear receptor signaling pathways regulating expression of HAGHL Gene:

HAGHL

SOURCE GeneReport for Unigene cluster for HAGHL Gene:

Hs.124015
genes like me logo Genes that share expression patterns with HAGHL: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HAGHL Gene

Orthologs for HAGHL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HAGHL Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HAGHL 34 35
  • 89.01 (n)
chimpanzee
(Pan troglodytes)
Mammalia HAGHL 34 35
  • 87.12 (n)
cow
(Bos Taurus)
Mammalia HAGHL 34 35
  • 86.33 (n)
rat
(Rattus norvegicus)
Mammalia Haghl 34
  • 81.72 (n)
mouse
(Mus musculus)
Mammalia Haghl 34 16 35
  • 80.99 (n)
oppossum
(Monodelphis domestica)
Mammalia HAGHL 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves HAGHL 34 35
  • 71.52 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia haghl 34
  • 64.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4365 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y17G7B.3 35
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLO2 35
  • 26 (a)
ManyToMany
GLO4 35
  • 26 (a)
ManyToMany
Species where no ortholog for HAGHL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HAGHL Gene

ENSEMBL:
Gene Tree for HAGHL (if available)
TreeFam:
Gene Tree for HAGHL (if available)

Paralogs for HAGHL Gene

Paralogs for HAGHL Gene

genes like me logo Genes that share paralogs with HAGHL: view

Variants for HAGHL Gene

Sequence variations from dbSNP and Humsavar for HAGHL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs200531006 Likely benign 725,161(+) CACAG(A/G/T)GCTGG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs138669350 Uncertain significance 725,236(+) ACTCA(C/T)GCCGC nc-transcript-variant, upstream-variant-2KB, reference, missense, splice-donor-variant
rs12446058 Benign 725,947(+) AGCAC(C/G)CTGGG intron-variant, upstream-variant-2KB
rs12448311 Benign 725,954(+) TGGGG(A/C)CCCAC intron-variant, upstream-variant-2KB
rs12448312 Benign 725,955(+) GGGGC(A/C)CCACA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HAGHL Gene

Variant ID Type Subtype PubMed ID
dgv4825n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457311 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571022 CNV loss 21841781
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for HAGHL Gene

Gene Damage Index Score: 1.44; 28.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAGHL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HAGHL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAGHL Gene

Disorders for HAGHL Gene

Relevant External Links for HAGHL

Human Genome Epidemiology (HuGE) Navigator
HAGHL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAGHL

No disorders were found for HAGHL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HAGHL Gene

Publications for HAGHL Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3 64

Products for HAGHL Gene

Sources for HAGHL Gene

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