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Aliases for HAGHL Gene

Aliases for HAGHL Gene

  • Hydroxyacylglutathione Hydrolase-Like 2 3
  • Hydroxyacyl Glutathione Hydrolase-Like 2
  • EC 3.1.2.- 4

External Ids for HAGHL Gene

Previous GeneCards Identifiers for HAGHL Gene

  • GC16U990171
  • GC16P000716
  • GC16P000717
  • GC16P000777
  • GC16P000701
  • GC16P000780
  • GC16P000781
  • GC16P000782
  • GC16P000789
  • GC16P000807
  • GC16P000832
  • GC16P000851

Summaries for HAGHL Gene

GeneCards Summary for HAGHL Gene

HAGHL (Hydroxyacylglutathione Hydrolase-Like) is a Protein Coding gene. Among its related pathways are Pyruvate metabolism. GO annotations related to this gene include hydroxyacylglutathione hydrolase activity. An important paralog of this gene is HAGH.

UniProtKB/Swiss-Prot for HAGHL Gene

  • Hydrolase acting on ester bonds.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAGHL Gene

Genomics for HAGHL Gene

Regulatory Elements for HAGHL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HAGHL Gene

Start:
726,924 bp from pter
End:
735,525 bp from pter
Size:
8,602 bases
Orientation:
Plus strand

Genomic View for HAGHL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAGHL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAGHL Gene

Proteins for HAGHL Gene

  • Protein details for HAGHL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PII5-HAGHL_HUMAN
    Recommended name:
    Hydroxyacylglutathione hydrolase-like protein
    Protein Accession:
    Q6PII5
    Secondary Accessions:
    • A6NCC4
    • D3DU64
    • Q59FX8
    • Q96BZ3
    • Q96NR5
    • Q96S11
    • Q9BT45

    Protein attributes for HAGHL Gene

    Size:
    290 amino acids
    Molecular mass:
    31557 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK61250.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD92568.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92568.1; Type=Miscellaneous discrepancy; Note=Sequence of unknown origin at the C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for HAGHL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAGHL Gene

Proteomics data for HAGHL Gene at MOPED

Post-translational modifications for HAGHL Gene

  • Ubiquitination at Lys34
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HAGHL Gene

Domains for HAGHL Gene

Protein Domains for HAGHL Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6PII5

UniProtKB/Swiss-Prot:

HAGHL_HUMAN :
  • Q6PII5
Family:
  • Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
genes like me logo Genes that share domains with HAGHL: view

No data available for Gene Families for HAGHL Gene

Function for HAGHL Gene

Molecular function for HAGHL Gene

UniProtKB/Swiss-Prot Function: Hydrolase acting on ester bonds.

Enzyme Numbers (IUBMB) for HAGHL Gene

Gene Ontology (GO) - Molecular Function for HAGHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004416 hydroxyacylglutathione hydrolase activity --
GO:0008270 zinc ion binding --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HAGHL: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HAGHL Gene

Localization for HAGHL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAGHL Gene COMPARTMENTS Subcellular localization image for HAGHL gene
Compartment Confidence
cytosol 3
extracellular 3
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HAGHL Gene

Pathways for HAGHL Gene

SuperPathways for HAGHL Gene

Superpath Contained pathways
1 Pyruvate metabolism
genes like me logo Genes that share pathways with HAGHL: view

Pathways by source for HAGHL Gene

1 KEGG pathway for HAGHL Gene

Interacting Proteins for HAGHL Gene

Gene Ontology (GO) - Biological Process for HAGHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006750 glutathione biosynthetic process --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with HAGHL: view

Compounds for HAGHL Gene

(4) HMDB Compounds for HAGHL Gene

Compound Synonyms Cas Number PubMed IDs
D-Lactic acid
  • (-)-Lactate
10326-41-7
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8
S-Lactoylglutathione
  • (R)-S-lactoylglutathione
25138-66-3
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with HAGHL: view

Transcripts for HAGHL Gene

Unigene Clusters for HAGHL Gene

Hydroxyacylglutathione hydrolase-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAGHL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAGHL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ·
SP1: - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7: - - - - - - - - -
SP8: - - -
SP9: -
SP10: -
SP11:

ExUns: 9d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for HAGHL Gene

GeneLoc Exon Structure for
HAGHL
ECgene alternative splicing isoforms for
HAGHL

Expression for HAGHL Gene

mRNA expression in normal human tissues for HAGHL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAGHL Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HAGHL Gene

SOURCE GeneReport for Unigene cluster for HAGHL Gene Hs.124015

genes like me logo Genes that share expressions with HAGHL: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HAGHL Gene

Orthologs for HAGHL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HAGHL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAGHL 35
  • 87.12 (n)
  • 83.39 (a)
HAGHL 36
  • 66 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HAGHL 35
  • 86.33 (n)
  • 88.13 (a)
HAGHL 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAGHL 35
  • 89.01 (n)
  • 88.77 (a)
HAGHL 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Haghl 35
  • 80.99 (n)
  • 82.67 (a)
Haghl 16
Haghl 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HAGHL 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Haghl 35
  • 81.72 (n)
  • 84.23 (a)
chicken
(Gallus gallus)
Aves HAGHL 35
  • 71.52 (n)
  • 67.27 (a)
HAGHL 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia haghl 35
  • 64.61 (n)
  • 61.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4365 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y17G7B.3 36
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLO2 36
  • 26 (a)
ManyToMany
GLO4 36
  • 26 (a)
ManyToMany
Species with no ortholog for HAGHL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HAGHL Gene

ENSEMBL:
Gene Tree for HAGHL (if available)
TreeFam:
Gene Tree for HAGHL (if available)

Paralogs for HAGHL Gene

Paralogs for HAGHL Gene

Selected SIMAP similar genes for HAGHL Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with HAGHL: view

Variants for HAGHL Gene

Sequence variations from dbSNP and Humsavar for HAGHL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs74711638 -- 729,103(+) GCTGT(C/T)GTCCC intron-variant, missense, reference
rs111850803 -- 729,011(+) CAGAA(A/G)AGGGA synonymous-codon, reference, intron-variant, missense, nc-transcript-variant
rs139384912 -- 729,032(+) GTGCC(C/T)ACTGT reference, synonymous-codon, intron-variant, missense, nc-transcript-variant
rs142973598 -- 729,044(+) CCGTC(A/G)ACTCT synonymous-codon, reference, intron-variant, missense, nc-transcript-variant
rs144286258 -- 729,129(+) ACGTG(A/G)ACCCT intron-variant, stop-gained, reference

Structural Variations from Database of Genomic Variants (DGV) for HAGHL Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904707 CNV Loss 21882294
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2479n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv904759 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
nsv904781 CNV Gain 21882294
nsv471065 CNV Gain 18288195
nsv9321 CNV Gain+Loss 18304495
dgv2491n71 CNV Loss 21882294
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
dgv2492n71 CNV Loss 21882294
nsv457311 CNV Loss 19166990
dgv2495n71 CNV Loss 21882294
nsv904812 CNV Loss 21882294
dgv2496n71 CNV Loss 21882294
dgv2497n71 CNV Loss 21882294

Relevant External Links for HAGHL Gene

HapMap Linkage Disequilibrium report
HAGHL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAGHL Gene

Disorders for HAGHL Gene

Relevant External Links for HAGHL

Human Genome Epidemiology (HuGE) Navigator
HAGHL
genes like me logo Genes that share disorders with HAGHL: view

No data available for UniProtKB/Swiss-Prot for HAGHL Gene

Publications for HAGHL Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for HAGHL Gene

Sources for HAGHL Gene

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