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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HAGH Gene

protein-coding   GIFtS: 61
GCID: GC16M001845

hydroxyacylglutathione hydrolase

(Previous name: hydroxyacyl glutathione hydrolase )
 Explore 13 diseases affiliated with
HAGH via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HAGH    

Aliases
for HAGH gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Hydroxyacylglutathione Hydrolase1 2     EC 3.1.2.63 8
GLO21 2 3 5     Hydroxyacyl Glutathione Hydrolase1
HAGH11 2 3     GLX22
GLXII1 2     Hydroxyacylglutathione Hydrolase, Mitochondrial2
Glx II2 3     Hydroxyacylglutathione Hydroxylase2
Glyoxalase II2 3     

External Ids:    HGNC: 48051   Entrez Gene: 30292   Ensembl: ENSG000000638547   OMIM: 1387605   UniProtKB: Q167753   

Export aliases for HAGH gene to outside databases

Previous GC identifers: GC16M001876 GC16M001797 GC16M001799


Summaries
for HAGH gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HAGH:
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of
S-lactoyl-glutathione to reduced glutathione and D-lactate. Two transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: GLO2_HUMAN, Q16775
Function: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid

Gene Wiki entry for HAGH


Genomic Views
for HAGH gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HAGH gene promoter:
         HOXA9B   HOXA9   HEN1   p53   HFH-1   XBP-1   MRF-2   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HAGH promoter sequence
   Search SABiosciences Chromatin IP Primers for HAGH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAGH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

HAGH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAGH gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001845:  view genomic region     (about GC identifiers)

Start:
 1,845,621 bp from pter      End:
 1,877,195 bp from pter
Size:
 31,575 bases      Orientation:
 minus strand

Proteins
for HAGH gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GLO2_HUMAN, Q16775 (See protein sequence)
Recommended Name: Hydroxyacylglutathione hydrolase, mitochondrial precursor  
Size: 308 amino acids; 33806 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Monomer
Subcellular location: Isoform 1: Mitochondrion matrix
Subcellular location: Isoform 2: Cytoplasm
Caution: Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants,
separate genes encode the cytosolic and mitochondrial forms of glyoxalase II
Sequence caution: Sequence=AAH00840.1; Type=Erroneous initiation; Sequence=CAA62483.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for HAGH:
1QH3 (3D)        1QH5 (3D)        2F50 (3D)    
Secondary accessions: A8K290 B4DRA7
Alternative splicing, Alternative initiation: 2 isoforms:  Q16775-1   Q16775-2   (Produced by alternative splicing. Also produced by alternative initiation at Met-49 of isoform 1)

Explore the universe of human proteins at neXtProt for HAGH: NX_Q16775

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16775

    • 4/6 DME Specific Peptides for HAGH (Q16775) (see all 6)
     PSTLAEE  VFTGDTL  VDPVQPQKV  THLSTLQVGSL 

    HAGH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035517.1  NP_005317.2  

    ENSEMBL proteins: 
     ENSP00000455355   ENSP00000457986   ENSP00000406552   ENSP00000380514   ENSP00000380511  
     ENSP00000455422   ENSP00000455970  

    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for HAGH
    Uscn Proteins for HAGH

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15117945
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix IEA--


    HAGH for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for HAGH gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HAGH for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001279 Beta-lactamas-like
     IPR017782 Hydroxyacylglutathione_Hdrlase

    Graphical View of Domain Structure for InterPro Entry Q16775

    ProtoNet protein and cluster: Q16775

    UniProtKB/Swiss-Prot: GLO2_HUMAN, Q16775
    Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family


    Function
    for HAGH gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GLO2_HUMAN, Q16775
    Function: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid
    Catalytic activity: S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate

         Genatlas biochemistry entry for HAGH:
    hydroxyacyl glutathione hydrolase

    Enzyme Number (IUBMB): EC 3.1.2.61 2

    miRNA
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    Inhib. RNA
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    Clone
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004416hydroxyacylglutathione hydrolase activity IDA8550579
    GO:0008270zinc ion binding IEA--


    HAGH for ontologies           About GeneDecksing



    Pathways & Interactions
    for HAGH gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Pyruvate metabolism
    		Pyruvate metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for HAGH):
        Pyruvate metabolism

    UniProtKB/Swiss-Prot: GLO2_HUMAN, Q16775
    Pathway: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2


    HAGH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HAGH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/36 Interacting proteins for HAGH (Q167753 ENSP000003805144) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOCQ999723, ENSP000000375024I2D: score=1 STRING: ENSP00000037502
    ISYNA1Q9NPH23, ENSP000003151474I2D: score=1 STRING: ENSP00000315147
    WDR45BQ5MNZ63I2D: score=4 
    PPA1Q151813I2D: score=2 
    AADATQ8N5Z03I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006749glutathione metabolic process ----
    GO:0006750glutathione biosynthetic process IDA8550579


    HAGH for ontologies           About GeneDecksing



    Drugs & Compounds
    for HAGH gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HAGH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HAGH

    4 HMDB Compounds for HAGH    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Lactic acid(-)-Lactate (see all 35)10326-41-7--
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    S-Lactoylglutathione(R)-S-lactoylglutathione (see all 13)25138-66-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for HAGH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17139284 11018726 17016423 3955057 8589803
    S-(N-Hydroxy-N-Bromophenylcarbamoyl)Glutathione-- --target--17139284 17016423

    10 Novoseek chemical compound relationships for HAGH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-d-lactoylglutathione 97.1 7 19062100 (1), 9486985 (1), 16803681 (1), 10508780 (1) (see all 6)
    s-p-nitrobenzoxycarbonylglutathione 95.7 3 1472100 (1), 8489699 (1), 8504817 (1)
    methylglyoxal 91.5 16 8636255 (2), 7859825 (2), 9486985 (1), 12572858 (1) (see all 12)
    trypanothione 72.5 3 16880563 (1), 14976196 (1), 18052346 (1)
    phosphoglycolate 71.5 2 1285890 (1), 2164460 (1)
    zinc 47.7 6 11847294 (2), 10438633 (1), 19413286 (1), 18533362 (1) (see all 5)
    lactate 38.9 6 9108256 (1), 9486985 (1), 14976196 (1), 10508780 (1) (see all 6)
    iron 5.31 2 19413286 (1), 11085979 (1)
    nacl 0 2 10944391 (1)
    glucose 0 2 9261170 (2)

    Search CenterWatch for drugs/clinical trials and news about HAGH / GLO2 

    Transcripts
    for HAGH gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HAGH gene (2 alternative transcripts): 
    NM_001040427.1  NM_005326.4  

    Unigene Cluster for HAGH:

    Hydroxyacylglutathione hydrolase
    Hs.157394  [show with all ESTs]
    Unigene Representative Sequence: NM_001040427
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564445 ENST00000566644 ENST00000455446 ENST00000397356(uc002cmz.3 uc002cna.3 uc010uvp.2)
    ENST00000397353 ENST00000567398 ENST00000563173 ENST00000566709 ENST00000569339
    ENST00000569700(uc010bry.1) ENST00000567190 ENST00000564518 ENST00000565097


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    Inhib. RNA
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    Additional cDNA sequence: 

    AK290155.1 AK298174.1 AK299173.1 AK299993.1 AK308825.1 AY576804.1 BC000840.1 BC002627.2 
    X90999.1 

    16 DOTS entries:

    DT.213917  DT.100791379  DT.112794  DT.120660260  DT.91988612  DT.40275778  DT.100836543  DT.100791383 
    DT.429235  DT.120660209  DT.40132030  DT.95338319  DT.100791375  DT.100791381  DT.100641547  DT.40276748 

    23 AceView cDNA sequences:

    NM_005326 AY576804 X90999 CR611189 CR614453 CR620966 CR612350 BC000840 
    AI914267 AK054943 BF511564 AI702768 BX428027 BX412661 BV191510 BC002627 
    AI268157 CK824895 CD620252 BV170933 AI689891 BX412125 BE719382 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HAGH (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
    SP1:                          -                       -     -     -           -                       -     -           -                     
    SP2:                                                  -     -     -           -                       -     -           -                     
    SP3:                                                  -     -     -           -                       -     -                                 
    SP4:                          -                       -     -     -           -     -                 -     -                                 
    SP5:                                                  -     -     -           -     -                                                         


    ECgene alternative splicing isoforms for HAGH

    Expression
    for HAGH gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HAGH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGGCCGTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HAGH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HAGH

    SOURCE GeneReport for Unigene cluster: Hs.157394

    UniProtKB/Swiss-Prot: GLO2_HUMAN, Q16775
    Tissue specificity: Expressed in liver and kidney

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    Orthologs
    for HAGH gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for HAGH gene from 11/40 species (see all 40)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hagh1 , 5 hydroxyacyl glutathione hydrolase1, 5 84.09(n)1
    87.66(a)1    		   17 (12.53 cM)5
    146511  NM_024284.21  NP_077246.21 
     248401435 
    chicken
    (Gallus gallus)    		 Aves HAGH1 hydroxyacylglutathione hydrolase 73.99(n)
    77.03(a)    		   416537  NM_001012789.1  NP_001012807.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HAGH6
    		 --
    		 75(a)
    		 1 ↔ 1
    		 GL343263.1(1350205-1360710)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ055563.12   -- 72.38(n)    BJ055563.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa66a032 wufa66a03 76.11(n)   336977  AY398356.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG43651 , 3 hydroxyacylglutathione hydrolase3
    CG43651    		 58(a)3
    63.8(n)1
    59.37(a)1    		   77E63
    402991  NM_141001.21  NP_649258.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y17G7B.31 , 3 Metallo-beta-lactamase superfamily3
    Protein Y17G7B.31    		 47(a)3
    49.28(n)1
    48.22(a)1    		   II(11988936-11991736)3
    1748391  NM_064155.31  NP_496556.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes GLO21 Glo2p 49.7(n)
    42.86(a)    		   851865   NP_010558.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons GLY21 Hydroxyacylglutathione hydrolase cytoplasmic 56.21(n)
    54.51(a)    		   820255  NM_111922.3  NP_187696.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.64802 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.78(n)    AK103161.1 


    ENSEMBL Gene Tree for HAGH (if available)
    TreeFam Gene Tree for HAGH (if available) 

    Paralogs
    for HAGH gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HAGH gene
    PNKD2  ETHE12  HAGHL2  
    2 SIMAP similar genes for HAGH using alignment to 6 protein entries:     GLO2_HUMAN (see all proteins):
    HAGHL    PNKD

    HAGH for paralogs           About GeneDecksing



    Genomic Variants
    for HAGH gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/630 NCBI SNPs in HAGH are shown (see all 630)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs796545411,2
    		C,--1858632(+) CCTTT-/GGTCCT 2 -- ds50010--------
    rs361199921,2
    		C,--1858633(+) CCTTT-/GTCCTG 2 -- ds50012Minor allele frequency- G:0.00NA CSA 4
    rs16234521,2
    		C,F,A,--1858766(+) AGGGCA/GGTTTG 2 -- ds500122Minor allele frequency- G:0.26NA MN CSA WA EA 1993
    rs725508411,2
    		F--1858801(-) TBGGCA/GGCACC 2 -- ds50015Minor allele frequency- G:0.01MN 400
    rs16235591,2
    		C,A,H,--1858805(+) CTGCCA/GAGTAG 2 -- ds500110Minor allele frequency- G:0.19NA WA CSA EA 371
    rs16235621,2
    		C,A,H,--1858808(+) CCGAGC/TAGGAG 2 -- ds500110Minor allele frequency- T:0.19NA WA CSA EA 371
    rs725472801,2
    		F,--1858810(-) TGCTCC/GTDCTB 2 -- ds50016Minor allele frequency- G:0.02MN WA 526
    rs725472341,2
    		F--1858844(-) CTGGAG/CGCGGC 2 -- ds50015Minor allele frequency- C:0.01MN 408
    rs725472351,2
    		F,--1858869(-) AGGGAG/CANGTG 2 -- ds50016Minor allele frequency- C:0.01MN WA 526
    rs16243871,2
    		C,F,A,H,--1858888(+) CCTGAA/GCAGAT 2 -- ds500134Minor allele frequency- G:0.27NS EA NA MN WA CSA 3843

    HapMap Linkage Disequilibrium report for HAGH (1845621 - 1877195 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for HAGH
         3 CNVs: 53272 5329 49668

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    Disorders / Diseases
    for HAGH gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HAGH for disorders           About GeneDecksing

    OMIM gene information: 138760    OMIM disorders: --

    13 diseases for HAGH:    About MalaCards
    glyoxalase ii deficiency    familial mediterranean fever    muscular dystrophy    thrombocytosis
    bladder carcinoma    hepatitis b    hyperglycemia    alzheimer's disease
    carcinoma    prostate cancer    breast cancer    hepatitis
    prostatitis

    4 Novoseek disease relationships for HAGH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kidney tumor 40 1 7585456 (1)
    breast carcinoma 3.93 1 11368412 (1)
    tumors 0 1 7585456 (1)
    cancer 0 2 1459997 (1), 8035422 (1)

    Human Genome Epidemiology (HuGE) Navigator: HAGH (2 documents)

    Export disorders for HAGH gene to outside databases

    Publications
    for HAGH gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HAGH gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with HAGH)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II. (PubMed id 15117945)1, 2, 9 Cordell P.A....Pease R.J. (2004)
    2. Molecular cloning, heterologous expression, and characterization of human glyoxalase II. (PubMed id 8550579)1, 2, 9 Ridderstroem M....Mannervik B. (1996)
    3. Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue. (PubMed id 10508780)1, 2, 9 Cameron A.D.... Mannervik B. (1999)
    4. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
    7. New regional localisations for HAGH and PGP on human chromosome 16. (PubMed id 3025077)1, 3 Mulley J.C. and Callen D.F. (1986)
    8. Assignment of the glyoxalase II gene (HAGH) to human chromosome 16. (PubMed id 7327557)1, 3 Honey N.K. and Shows T.B. (1981)
    9. Human glyoxalase II contains an Fe(II)Zn(II) center b ut is active as a mononuclear Zn(II) enzyme. (PubMed id 19413286)1, 9 Limphong P....Crowder M.W. (2009)
    10. Overexpression of glyoxalase system enzymes in human kidney tumor. (PubMed id 16803681)1, 9 Antognelli C....Mearini E. (2006)

    External Searches for HAGH gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HAGH gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3029 HGNC: 4805 AceView: HAGH Ensembl:ENSG00000063854 euGenes: HUgn3029
    ECgene: HAGH Kegg: 3029 H-InvDB: HAGH

    Other Databases showing HAGH gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HAGH gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HAGH Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HAGH gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HAGH gene:
    Search GeneIP for patents involving HAGH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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