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Aliases & Descriptions for HAGH
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 3.1.2.6 3 GLO2 1 , 2 , 3 , 5 GLX2 2 GLXII 1 , 2 HAGH1 1 , 2 , 3
Descriptions Glx II 3 Glyoxalase II 2 , 3 hydroxyacyl glutathione hydrolase 1 hydroxyacylglutathione hydrolase 2 hydroxyacylglutathione hydroxylase 2
Search outside databases for aliases for HAGH genePrevious GC identifers: GC16M001876 GC16M001797
Summaries for HAGH (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for HAGH : The enzyme encoded by this gene is classified as a thiolesterase and is responsible for thehydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. [provided by RefSeq] UniProtKB/Swiss-Prot: GLO2_HUMAN, Q16775 Function : Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to formglutathione and D-lactic acid
Gene Wiki entry for HAGH
Genomic Location for HAGH
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the HAGH gene Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3 HAGH Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16M001799:
(about GC identifiers )
Start:
1,799,105 bp from pter
End:
1,817,196 bp from pter
Size:
18,092 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000016.8 NT_037887.4 Proteins for HAGH
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: GLO2_HUMAN, Q16775 (See
protein sequence )Recommended Name: Hydroxyacylglutathione hydrolase Size : 260 amino acids; 28860 Da
Cofactor : Binds 2 zinc ions per subunit
Subunit : Monomer
PDB structures from and Proteopedia : 1QH3 (3D)
 1QH5 (3D)
 2F50 (3D)
 
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001035517.1 NP_005317.2 ENSEMBL proteins: ENSP00000380511 ENSP00000262303 ENSP00000380514 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: HAGH Antibodies for HAGH: Assays for HAGH:
Protein
Domains/ Families for HAGH(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q16775 ProtoNet protein and cluster: Q16775
UniProtKB/Swiss-Prot: GLO2_HUMAN, Q16775 Similarity : Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family
Gene Function for HAGH
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001040427 Applied Biosystems Silencer ® siRNAs for HAGH Sigma-Aldrich siRNA and siRNA Panels for HAGH Sigma-Aldrich shRNA for HAGH Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040427                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040427                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001040427  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005326 UniProtKB/Swiss-Prot: GLO2_HUMAN, Q16775 Function : Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to formglutathione and D-lactic acid Catalytic activity : S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylateEnzyme Number (IUBMB): EC 3.1.2.6
Genatlas biochemistry entry for HAGH :hydroxyacyl glutathione hydrolase 4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for HAGH
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for HAGH (Your Favorite Gene powered by Ingenuity) UniProtKB/Swiss-Prot: GLO2_HUMAN, Q16775 Pathway : Secondary metabolite metabolism; methylglyoxal degradation; D-lactate from methylglyoxal:step 2/2
Gene Network CentralTM Interacting Genes and Proteins Network for HAGH 5 Interacting proteins for HAGH (ENSP00000262303 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for HAGH (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for HAGH 8 Novoseek chemical compound relationships for HAGH gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
s-p-nitrobenzoxycarbonylglutathione
95.94
3
1472100 (1), 8489699 (1), 8504817 (1)
methylglyoxal
91.67
16
8636255 (2), 7859825 (2), 9486985 (1), 12572858 (1) (see all 12 )
trypanothione
73.80
3
16880563 (1), 14976196 (1), 18052346 (1)
phosphoglycolate
72.52
2
1285890 (1), 2164460 (1)
zinc
42.62
5
11847294 (2), 10438633 (1), 18533362 (1), 11085979 (1)
nacl
0.00
2
10944391 (1)
glucose
0.00
2
9261170 (2)
iron
0.00
1
11085979 (1)
About this table
Transcripts for HAGH(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001040427 Sigma-Aldrich siRNA and siRNA Panels for HAGH Sigma-Aldrich shRNA for HAGH Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001040427 NM_005326
REFSEQ mRNAs for HAGH gene (2 alternative transcripts): NM_001040427.1 NM_005326.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001040427 NM_005326
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040427                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040427                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001040427  
Additional cDNA sequence: AK290155.1 AK298174.1 AK299173.1 AK299993.1 AK308825.1 AY576804.1 BC000840.1 BC002627.2 CR611189.1 CR612350.1 CR614453.1 CR620966.1 X90999.1
16 DOTS entries : DT.213917 DT.100791379 DT.112794 DT.91988612 DT.120660260 DT.40275778 DT.100836543 DT.429235 DT.100791383 DT.120660209 DT.40132030 DT.95338319 DT.100791375 DT.100791381 DT.100641547 DT.40276748
23 AceView cDNA sequences :BC000840 CR620966 X90999 NM_005326 CR611189 AY576804 CR612350 CR614453 BC002627 AK054943 BX412661 BV191510 AI914267 BX428027 AI702768 AI268157 BF511564 CK824895 CD620252 AI689891 BV170933 BX412125 BE719382
highest scoring ESTs for HAGH :AI689891 AY576804 BC000840 BC002627 X90999 BE797513 AA444390 AI268157 BE515301 BE546227
Unigene Cluster for HAGH: Hydroxyacylglutathione hydrolase Hs.157394 [show with all ESTs ] Unigene Representative Sequence: NM_001040427 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HAGH (see all 10
) ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d SP1 :         -         -   -   -     -         -   -     -         SP2 :                 -   -   -     -         -   -     -         SP3 :                 -   -   -     -         -   -             SP4 :         -         -   -   -     -   -       -   -             SP5 :                 -   -   -     -   -                    
About this scheme ECgene alternative splicing isoforms for HAGH 3 Ensembl transcripts including schematic representations : ENST00000397353
ENST00000262303
ENST00000397356
Expression for HAGH
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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HAGH expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for HAGH 1 / 2 / 3
3 probe-sets matching HAGH gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.157394 Expression variation in blood from EXPOLDB for HAGH
Orthologs for HAGH
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for HAGH gene from 5/21 species (see all 21
)
About this table Species with no ortholog for HAGH ENSEMBL Gene Tree for HAGH Paralogs for HAGH (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for HAGH gene ETHE1 2 PNKD 2 HAGHL 2
SNPs/Variants for HAGH (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for HAGH (up to first 250kb)
Disorders & Mutations for HAGH
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 138760
4 Novoseek disease relationships for HAGH gene
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Medical News for HAGH (Possibly Related Articles in
Doctor's Guide )
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--
Publications for HAGH (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/80 PubMed articles for HAGH gene (see all 80
): Molecular cloning, heterologous expression, and characterization of human glyoxalase II. (PubMed id 8550579) 1, 3, 4 Ridderstroem M....Mannervik B. (1996) Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue. (PubMed id 10508780) 1, 3, 4 Cameron A.D.... Mannervik B. (1999) The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553) 3, 4 Martin J.... Pennacchio L.A. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797) 3, 4 Daniels R.J....Higgs D.R. (2001) New regional localisations for HAGH and PGP on human chromosome 16. (PubMed id 3025077) 2, 3 Mulley J.C. and Callen D.F. (1986) Assignment of the glyoxalase II gene (HAGH) to human chromosome 16. (PubMed id 7327557) 2, 3 Honey N.K. and Shows T.B. (1981) The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II. (PubMed id 15117945) 1, 3 Cordell P.A....Pease R.J. (2004) Overexpression of glyoxalase system enzymes in human kidney tumor. (PubMed id 16803681) 1, 3 Antognelli C....Mearini E. (2006) Glyoxalase activities in tumor and non-tumor human urogenital tissues. (PubMed id 7585456) 1, 3 Di Ilio C....Sacchetta P. (1995)
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Genome Databases showing HAGH
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Specialized Databases showing HAGH (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for HAGH (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for HAGH:
Recombinant Proteins (HAGH ) Antibodies (HAGH )
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