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HADH Gene

protein-coding GIFtS: 57

GC04P109130

hydroxyacyl-Coenzyme A dehydrogenase
(Previous names: L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HADHSC)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.1.1.35 ^³
HAD ^², ³
HADH1 ^¹, ²
HADHSC ^², ³
HCDH ^³
HHF4 ^²
M/SCHAD ^²
MGC8392 ^²
SCHAD ^¹, ², ³

Descriptions
L-3-hydroxyacyl-Coenzyme A dehydrogenase ^²
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain ^¹, ²
Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase ^³
Short chain 3-hydroxyacyl-CoA dehydrogenase ^³
hydroxyacyl-Coenzyme A dehydrogenase ^²

External Ids
HGNC: 4799¹
Entrez Gene: 3033²
UniProtKB: Q16836³
Ensembl: ENSG00000138796⁷

Search outside databases for aliases for HADH gene

Previous GC identifer: GC07U990046

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HADH:

This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein

functions in the mitochondrial matrix to catalyze the oxidation of straight-chain

3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with

medium-chain-length fatty acids. Mutations in this gene cause one form of familial

hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene. [provided by

RefSeq]

UniProtKB/Swiss-Prot: HCDH_HUMAN, Q16836

Function: Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids.

Exerts it highest activity toward 3-hydroxybutyryl-CoA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22-q26 Ensembl cytogenetic band: 4q25 HGNC cytogenetic band: 4q22-q26

HADH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P109130: (about GC identifiers)

Start:	109,130,319 bp from pter
End:	109,175,780 bp from pter
Size:	45,462 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: HCDH_HUMAN, Q16836 (See protein sequence)

Recommended Name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor

Size: 314 amino acids; 34278 Da

Subunit: Homodimer

Subcellular location: Mitochondrion matrix

PDB structures from and Proteopedia :

1F0Y (3D)

1F12 (3D)

1F14 (3D)

1F17 (3D)

1IL0 (3D)

1LSJ (3D)

1LSO (3D)

1M75 (3D)

1M76 (3D)

2HDH (3D)

3HAD (3D)

Secondary accessions: O00324 O00397 O00753

Alternative splicing: 2 isoforms: Q16836-1 Q16836-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005318.2

ENSEMBL proteins:

ENSP00000265168 ENSP00000385638 ENSP00000312288

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HADHSC)
	Human Recombinant Proteins from Abnova (HADHSC)

OriGene Purified Recombinant Human Protein: HADH

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	11256614
GO:0005739	mitochondrion	TAS	8687463
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0005759	mitochondrial matrix	IEA	--

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Antibodies for HADH:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HADH
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (HADHSC), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HADHSC)
	Novus Biologicals Antibodies for HADH

Assays for HADH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q16836

ProtoNet protein and cluster: Q16836

2 Blocks protein families:

IPB006176 3-hydroxyacyl-CoA dehydrogenase

IPB006180 3-hydroxyacyl-CoA dehydrogenase

UniProtKB/Swiss-Prot: HCDH_HUMAN, Q16836

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HADH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HADHSC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005327

Applied Biosystems Silencer® siRNAs for HADH

Sigma-Aldrich siRNA for HADH

Sigma-Aldrich shRNA for HADH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HADH
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005327
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005327
untagged cDNA clone in CMV expression vector: NM_005327

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005327

UniProtKB/Swiss-Prot: HCDH_HUMAN, Q16836

Function: Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids.

Exerts it highest activity toward 3-hydroxybutyryl-CoA

Catalytic activity: (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH

Enzyme Number (IUBMB): EC 1.1.1.35

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	TAS	8687463
GO:0005488	binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0050662	coenzyme binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for HADH (Your Favorite Gene powered by Ingenuity) (see all 7 )

Butanoate Metabolism
Fatty Acid Metabolism
Lysine Degradation
Fatty Acid Elongation in Mitochondria
Tryptophan Metabolism

GeneDecks HADH for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: HCDH_HUMAN, Q16836

Pathway: Lipid metabolism; fatty acid beta-oxidation

Gene Network Central^TM Interacting Genes and Proteins Network for HADH

5/34 Interacting proteins for HADH (ENSP00000265168³) via UniProtKB, MINT, and/or STRING (see all 34 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ECHS1	ENSP00000357535³	STRING (score=.993)
ACAA2	ENSP00000285093³	STRING (score=.979)
FOXA2	ENSP00000366319³	STRING (score=.975)
ECHDC2	ENSP00000360577³	STRING (score=.973)
ACAT2	ENSP00000356015³	STRING (score=.956)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	IEA	--
GO:0006631	fatty acid metabolic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HADH
7 Novoseek chemical compound relationships for HADH gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty acid	61.76	10	9716664 (1), 14641012 (1), 17065362 (1), 17491019 (1) (see all 7)
acyl-coa	58.58	2	15347768 (1), 17442290 (1)
katp	55.89	2	17185391 (1)
nad+	45.48	4	10231530 (3), 10548046 (1)
nadh	26.82	2	10231530 (2)
glucose	21.20	3	17491019 (2)
leucine	19.16	1	11489939 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HADH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HADHSC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005327

Sigma-Aldrich siRNA for HADH

Sigma-Aldrich shRNA for HADH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005327

REFSEQ mRNAs for HADH gene:

NM_005327.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005327

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005327
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005327
                                 untagged cDNA clone in CMV expression vector: NM_005327

Additional cDNA sequence:

AF001902.1 AF001903.1 AK096018.1 AK314444.1 BC000306.2 CR590438.1 CR591982.1 CR592199.1

CR593079.1 CR616506.1 CR618120.1 X96752.1

11 DOTS entries:

DT.454550 DT.97770815 DT.95127733 DT.217941 DT.100817974 DT.95127731 DT.100817977 DT.100817983

DT.121276253 DT.97803912 DT.121276237

24/340 AceView cDNA sequences (see all 340 ):

AI095852 AI123379 BX419040 CA393734 AL572990 BM797221 BM676252 BG166962

BM783903 AI089645 BM510048 AI346992 CB126339 BM771929 AI625958 CR616506

CA941970 BM312222 AA601524 BQ182966 CR591982 AI890436 AA359010 BG505143

highest scoring ESTs for HADH:

AF001903 X96752 AA011651 AA029885 AA030023 AA043935 AA047784 AA057130 AA057196 AA074725

Unigene Cluster for HADH:

Hydroxyacyl-Coenzyme A dehydrogenase

Hs.438289 [show with all ESTs]

Unigene Representative Sequence: NM_005327

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HADH (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b
SP1:									-		-		-																-
SP2:													-																-		-
SP3:									-		-		-																-		-
SP4:									-				-
SP5:

About this scheme

ECgene alternative splicing isoforms for HADH

3 Ensembl transcripts including schematic representations:

ENST00000351726 ENST00000403312 ENST00000309522

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HADH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HADH

¹ / ² / ³

8 probe-sets matching HADH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38768_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.01	X96752	1.00	1.00	1.00	1
35435_s_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.99	AF001903	1.00	1.00	1.00	1
201036_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005327	0.60	1.00	0.82	1
201035_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000306	0.80	1.00	0.91	1
211569_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF001903	1.00	1.00	1.00	1
201036_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201035_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211569_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HADH for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGAAATCACT

SOURCE GeneReport for Unigene cluster: Hs.438289
UniProtKB/Swiss-Prot: HCDH_HUMAN, Q16836
Tissue specificity: Expressed in liver, kidney, pancreas, heart and skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HADH gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HADH¹	--	hydroxyacyl-Coenzyme A dehydrogenase	89.53(n) 92.63(a)	478506 XM_535685.2 XP_535685.2
chimpanzee (Pan troglodytes)	HADH¹	--	hydroxyacyl-Coenzyme A dehydrogenase	99.47(n) 99.04(a)	461424 XM_517385.2 XP_517385.2
cow (Bos taurus)	HADH¹	--	hydroxyacyl-Coenzyme A dehydrogenase	88.29(n) 90.1(a)	613570 XM_871800.2 XP_876893.2
rat (Rattus norvegicus)	Hadh¹	--	hydroxyacyl-Coenzyme A dehydrogenase	85.46(n) 90.13(a)	113965 NM_057186.1 NP_476534.1
mouse (Mus musculus)	Hadh^{1, 5}	3⁵	hydroxyacyl-Coenzyme A dehydrogenase^{1, 5}	84.82(n)¹ 89.81(a)¹	15107¹ NM_008212.3¹ NP_032238.2¹ AA409008⁵ AF375596⁵ (see all 25)

About this table Species with no ortholog for HADH

ENSEMBL Gene Tree for HADH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HADH gene

EHHADH² HADHA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/321 NCBI SNPs in HADH are shown (see all 321 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 144)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4956145^1,2	A,C,F,H	109150488(+)	`AAACCC/TTAAGG`	1	L/P	mis¹		14		MN EA NA EU WA	1278
	rs6831530^1,2	A,C,F,H	109175872(+)	`GCCTGG/TGGCCG`	1	--	ng3¹		7		EU EA WA NA	562
	rs221347^1,2	C,F,H,O	109175071(+)	`TACAGT/ATTAAT`	1	--	ut3¹ ese³		16		MN EU EA WA NA	1582
	rs1051519^1,2	C,F	109160181(+)	`TTGCAG/TATTAC`	1	Q/H	mis¹ ese³		5		MN EU EA WA	604
	rs3822294^1,2	F,H	109175267(+)	`TTGCCT/AAGATT`	1	--	ut3¹ ese³		4		EU EA WA	420
--	rs3836723^1,2	C	109129636(+)	`TTTTT-/TGTTAA`	1	--	ng5¹		0	--	--	--	--
	rs10017687^1,2	C	109130345(+)	`GGGACG/ATTACA`	1	--	ng5¹		5		NA MN EA	492
--	rs221336^1,2	C	109129437(+)	`gttctC/Tctaac`	1	--	ng5¹		0	--	--	--	--
--	rs17038277^1,2	F	109128960(+)	`TAACCG/TCCATA`	1	--	ng5¹		3		NA	136
	rs17038278^1,2	F	109130290(+)	`TCGGGC/ATCCGG`	1	--	ng5¹		3		NA	136

About this table

HapMap Linkage Disequilibrium images for HADH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601609

UniProtKB/Swiss-Prot: HCDH_HUMAN, Q16836

Defects in HADH are the cause of 3-alpha-hydroxyacyl-CoA dehydrogenase deficiency (HADH

deficiency) [MIM:231530]. HADH deficiency is a metabolic disorder with various clinical

presentations including hypoglycemia, hepatoencephalopathy, myopathy or cardiomyopathy, and in

some cases sudden death

Defects in HADH are the cause of familial hyperinsulinemic hypoglycemia 4 (HHF4)

[MIM:609975]. Inappropriately elevated insulin secretion is the hallmark of persistent

hyperinsulinemic hypoglycemia of infancy (PHHI), also denoted congenital hyperinsulinism. PHHI is

due to defective negative feedback regulation of insulin secretion by low glucose levels. Unless

early and aggressive intervention is undertaken, brain damage from recurrent episodes of

hypoglycemia may occur. HHF4 should be easily recognizable by analysis of acylcarnitine species

and that this disorder responds well to treatment with diazoxide. It provides the first

"experiment of nature" that links impaired fatty acid oxidation to hyperinsulinism and that

provides support for the concept that a lipid signaling pathway is implicated in the control of

insulin secretion

3 Novoseek disease relationships for HADH gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperinsulinism	87.20	8	14641012 (1), 18156285 (1), 17065362 (1), 17185391 (1) (see all 7)
hypoglycemia	64.72	3	17491019 (2), 14693719 (1)
enzyme deficiency	55.67	1	8795843 (1)

About this table

GeneTests: HADH

Familial Hyperinsulinism

Human Gene Mutation Database: HADH
Human Genome Epidemiology Navigator: HADH (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/42 PubMed articles for HADH gene (see all 42 ):

3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease. (PubMed id 16176262)^{1, 2, 3, 4} Yang S.Y....Schulz H. (2005)
Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism. (PubMed id 10231530)^{1, 3, 4} Barycki J.J.... Banaszak L.J. (1999)
Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence. (PubMed id 8687463)^{1, 3, 4} Vredendaal P.J.C.M.... Berger R. (1996)
Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion. (PubMed id 11489939)^{1, 3, 4} Clayton P.T....van den Berg I.E.T. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Sequestration of the active site by interdomain shifting. Crystallographic and spectroscopic evidence for distinct conformations of L-3-hydroxyacyl-CoA dehydrogenase. (PubMed id 10840044)^{3, 4} Barycki J.J.... Banaszak L.J. (2000)
A preliminary analysis of the segregation of human hydroxyacyl coenzyme A dehydrogenase in human-mouse somatic cell hybrids. (PubMed id 975867)^{2, 3} Craig I....Bobrow M. (1976)
The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study. (PubMed id 17065362)^{1, 3} van Hove E.C....'t Hart L.M. (2006)
Structural organization of the human short-chain L-3-hydroxyacyl-CoA dehydrogenase gene. (PubMed id 9716664)^{1, 3} Vredendaal P.J....Berger R. (1998)
Fatal hepatic short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase deficiency: clinical, biochemical, and pathological studies on three subjects with this recently identified disorder of mitochondrial beta-oxidation. (PubMed id 10347277)^{1, 3} Bennett M.J....Wanders R.J. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3033	HGNC: 4799	AceView: HADHSC	Ensembl:ENSG00000138796	euGenes: HUgn3033
ECgene: HADH	H-InvDB: HADH

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=HADH

Licensable Technologies for HADH
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HADH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HADH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HADH		Antibodies for HADH
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HADH		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
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	Recombinant Proteins (HADHSC)
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	Recombinant Proteins (HADHSC)
	Antibodies (HADHSC)

	Tagged/untagged cDNA clones
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Antibodies for HADH

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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HADH Gene at Home site.
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HADH Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for HADH

Summaries
for HADH

Genomic Location
for HADH

Proteins
for HADH

Protein Domains/
Families
for HADH

Gene Function
for HADH

Pathways & Interactions
for HADH

Drugs & Compounds
for HADH

Transcripts
for HADH

Expression
for HADH

Orthologs
for HADH

Paralogs
for HADH

SNPs/Variants
for HADH

Disorders & Mutations
for HADH

Medical News
for HADH

Publications
for HADH

Search for HADH

Genome Databases showing HADH

Other Databases showing HADH

Specialized Databases showing HADH

Licensable Technologies
for HADH

Services
for HADH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HADH Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor HADH

Summariesfor HADH

Genomic Locationfor HADH

Proteinsfor HADH

Protein Domains/Familiesfor HADH

Gene Functionfor HADH

Pathways & Interactionsfor HADH

Drugs & Compoundsfor HADH

Transcriptsfor HADH

Expression for HADH

Orthologsfor HADH

Paralogsfor HADH

SNPs/Variantsfor HADH

Disorders & Mutationsfor HADH

Medical Newsfor HADH

Publicationsfor HADH

Search for HADH

Genome Databases showing HADH

Other Databases showing HADH

Specialized Databases showing HADH

Licensable Technologiesfor HADH

Servicesfor HADH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HADH

Summaries
for HADH

Genomic Location
for HADH

Proteins
for HADH

Protein Domains/
Families
for HADH

Gene Function
for HADH

Pathways & Interactions
for HADH

Drugs & Compounds
for HADH

Transcripts
for HADH

Expression
for HADH

Orthologs
for HADH

Paralogs
for HADH

SNPs/Variants
for HADH

Disorders & Mutations
for HADH

Medical News
for HADH

Publications
for HADH

Licensable Technologies
for HADH

Services
for HADH