HACE1 Gene
protein-coding GIFtS: 54
GCID: GC06M105221
|
|
HECT domain and ankyrin repeat containing E3 ubiquitin protein...
| |
Aliases
for HACE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HECT Domain And Ankyrin Repeat Containing E3 Ubiquitin Protein Ligase 11 2 | | HECT Domain And Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 12 | | KIAA13201 3 5 | | EC 6.3.2.-3 | | HECT Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 12 3 | | HACE5 | | E3 Ubiquitin-Protein Ligase HACE12 | | EC 6.3.28 |
Export aliases for HACE1 gene to outside databasesPrevious GC identifers: GC06M105176 GC06M105282 GC06M102619 |
Summaries
for HACE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HACE1_HUMAN, Q8IYU2Function: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as aregulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulatespostmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitinationserving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1,mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense againstpathogens. May also act as a transcription regulator via its interaction with RARB
|
Genomic Views
for HACE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HACE1 gene promoter:
NRSF form 1 NRSF form 2 AP-2gamma C/EBPalpha Evi-1 S8 E2F-1 E2F c-Myb FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HACE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HACE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q16.3 Ensembl cytogenetic band: 6q16.3 HGNC cytogenetic band: 6q21HACE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M105221: view genomic region
(about GC identifiers)
Start:
|
105,175,968 bp from pter |
End:
|
105,307,794 bp from pter |
Size:
|
131,827 bases |
Orientation:
|
minus strand |
|
Proteins
for HACE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HACE1_HUMAN, Q8IYU2 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase HACE1 Size: 909 amino acids; 102342 Da
Subunit: Interacts with RARB (By similarity). Interacts with RAB1 (RAB1A, RAB1B or RAB1C), RAB4 (RAB4A or RAB4B) andRAB11 (RAB11A or RAB11B); in a GTP-dependent manner. Interacts with RAC1; in a GTP-dependent manner. Interacts withthe 26S proteasomal complex through the 20S core proteasomal subunit
Subcellular location: Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. Note=A significantportion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins
Developmental stage: Expressed in fetal and pediatric kidney cells
Sequence caution: Sequence=BAA92558.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAG57487.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG62066.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAH14462.1; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=CAH71890.1; Type=Erroneous gene model prediction;Sequence=CAH74024.1; Type=Erroneous gene model prediction; Sequence=CAI16815.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K6U5 B3KY89 B4DFM6 B4DTQ4 B7Z9X6 E9PGP0 Q5VU99 Q5VUA0 Q8ND12 Q9P2M6Alternative splicing: 4 isoforms: Q8IYU2-1 Q8IYU2-2 Q8IYU2-3 Q8IYU2-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HACE1: NX_Q8IYU2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYU2
4/5 DME Specific Peptides for HACE1 (Q8IYU2) (see all 5)
HACE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065822.2
ENSEMBL proteins: ENSP00000262903 ENSP00000392425 ENSP00000358121 ENSP00000428110 ENSP00000429520 ENSP00000430898 ENSP00000429765 ENSP00000427901 ENSP00000430669
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
HACE1 for ontologies About GeneDecksing
HACE1 Antibody Products:
Assay Products for HACE1: |
Protein
Domains /
Families
for HACE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HACE1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYU2ProtoNet protein and cluster: Q8IYU2 2 Blocks protein families: IPB000569 HECT domain (Ubiquitin-protein ligase) IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: HACE1_HUMAN, Q8IYU2Similarity: Contains 6 ANK repeatsSimilarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain |
Function
for HACE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HACE1_HUMAN, Q8IYU2Function: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as aregulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulatespostmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitinationserving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1,mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense againstpathogens. May also act as a transcription regulator via its interaction with RARBInduction: Down-regulated in sporadic Wilms tumorEnzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HACE1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HACE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HACE1 (NM_020771) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HACE1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HACE1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HACE1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
IDA | -- | | GO:0017137 | Rab GTPase binding |
IDA | -- | | GO:0048365 | Rac GTPase binding |
IPI | -- |
HACE1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for HACE1:
Animal Models:
Mouse knock-out Hace1tm1Pngr for HACE1
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Hace1):
HACE1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HACE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitin-Proteasome Dependent Proteolysis | | | 2 | SMAD Signaling Network | |
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HACE1
UniProtKB/Swiss-Prot: HACE1_HUMAN, Q8IYU2Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HACE1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for HACE1 (Q8IYU23 ENSP000002629034) via UniProtKB, MINT, STRING, and/or I2D (see all 7) About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
HACE1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HACE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HACE1
Search CenterWatch for drugs/clinical trials and news about HACE1
|
Transcripts
for HACE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HACE1 gene: NM_020771.3 Unigene Cluster for HACE1: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 Hs.434340 [show with all ESTs]Unigene Representative Sequence: AB03774112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262903(uc010kcx.1 uc003pqu.1 uc010kcz.1) ENST00000369127(uc003pqt.1)
ENST00000517995 ENST00000416605(uc010kcy.1) ENST00000369125 ENST00000518402
ENST00000518503 ENST00000518228 ENST00000517424 ENST00000519645 ENST00000524020
ENST00000521962
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HACE1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HACE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HACE1 (NM_020771) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HACE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HACE1 |
Additional cDNA sequence: AB037741.1 AJ420474.1 AK124268.1 AK131207.1 AK291760.1 AK292683.1 AK294164.1 AK300314.1 AK311633.1 AK316091.1 AL834202.1 BC034982.2 BC038119.1 BC041919.1 7 DOTS entries: DT.441135 DT.102825254 DT.101982466 DT.75198210 DT.100749435 DT.95333293 DT.100671861 24/69 AceView cDNA sequences (see all 69): BM904923 AI872447 NM_020771 AA321932 AB037741 BC041919 BU622562 CA450182 AA678428 AL706627 BC034982 AL834202 BQ268728 BI602366 AK131207 BM557240 BC038119 BU570591 BG705644 BG181830 BF439293 CD109812 AW317008 AK124268
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for HACE1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24a | · | 24b | · | 24c |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | |
ECgene alternative splicing isoforms for HACE1
|
Expression
for HACE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HACE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTTAGGA
About this image
See HACE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HACE1
SOURCE GeneReport for Unigene cluster: Hs.434340
UniProtKB/Swiss-Prot: HACE1_HUMAN, Q8IYU2Tissue specificity: Expressed in multiple tissues including heart, brain and kidney
SABiosciences Expression via Pathway-Focused PCR Array including HACE1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HACE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HACE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HACE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HACE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HACE1 |
Orthologs
for HACE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HACE1 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HACE11 |
HECT domain and ankyrin repeat containing, E3 ubiquitin more |
84.06(n)
94.28(a) |
|
421788 NM_001031078.1 NP_001026249.1 |
lizard
(Anolis carolinensis) |
Reptilia |
HACE16 |
-- |
89(a) |
1 ↔ 1 |
GL343430.1(344161-390594) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.228912 |
Xenopus laevis transcribed sequence with weak similarity more |
81.71(n) |
|
BJ035370.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5724301 |
e3 ubiquitin-protein ligase HACE1-like |
74.12(n)
88.03(a) |
|
572430 XM_696143.5 XP_701235.5 |
ENSEMBL Gene Tree for HACE1 (if available)
TreeFam Gene Tree for HACE1 (if available) |
Paralogs
for HACE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HACE1 gene
- NEDD4L2 HECW22 WWP22 KIAA03172 SMURF22 HECW12 SMURF12 ITCH2
- NEDD42 WWP12
18/32 SIMAP similar genes for HACE1 using alignment to 9 protein entries: HACE1_HUMAN (see all proteins)
(see all similar genes):UBE3A HECW1 RAI14 WWP1 UACA INVS
ANKRD44 ANKRD54 CASKIN2 DKFZp761E1322 MTPN UBR5
HUWE1 WWP2 PSMD10 HECTD1 SMURF2 ANKDD1A
HACE1 for paralogs About GeneDecksing
|
Genomic Variants
for HACE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HACE1 (105175968 - 105307794 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for HACE1
9 CNVs: 99650 64620 32831 81520 3632 93927 99651 36445 39467
2 Indels: 46960 81521
Human Gene Mutation Database (HGMD): HACE1
| SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing HACE1: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HACE1 |
|
Disorders
/ Diseases
for HACE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HACE1 for disorders About GeneDecksing
OMIM gene information: 610876
OMIM disorders: --
UniProtKB/Swiss-Prot: HACE1_HUMAN, Q8IYU2
Note=Defects in HACE1 are a cause of Wilms tumor (WT). WT is a pediatric malignancy of kidney and one of themost common solid cancers in childhood. HACE1 is epigenetically down-regulated in sporadic Wilms tumor. Moreover, at(5;6)(q21;q21) translocation that truncates HACE1 has been found in a child with bilateral, young-onset Wilms tumor
5  diseases for HACE1: About MalaCardswilms tumor celiac disease colorectal cancer malaria
carcinoma
Human Genome Epidemiology (HuGE) Navigator: HACE1 (2 documents)
Export disorders for HACE1 gene to outside databases
|
Publications
for HACE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HACE1 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with HACE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Differential expression of a novel ankyrin containing E3 ubiquitin- protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. (PubMed id 15254018)1, 2, 9 Anglesio M.S....Sorensen P.H.B. (2004)
- The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1. (PubMed id 22036506)1, 2 Torrino S.... Lemichez E. (2011)
- The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle. (PubMed id 21988917)1, 2 Tang D....Wang Y. (2011)
- The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. (PubMed id 17694067)1, 2 Zhang L....Penninger J.M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- HACE1: A novel repressor of RAR transcriptional activity. (PubMed id 19350571)1, 9 Zhao J....Soprano D.R. (2009)
- Genome-wide association study of obsessive-compulsive disorder. (PubMed id 22889921)1 Stewart S.E....Pauls D.L. (2012)
- Common variation at 6q16 within HACE1 and LIN28B influ ences susceptibility to neuroblastoma. (PubMed id 22941191)1 Diskin S.J....Maris J.M. (2012)
|
External Searches for HACE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HACE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HACE1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing HACE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HACE1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HACE1 gene:
Search GeneIP for patents involving HACE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HACE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for HACE1 | | OriGene shRNA RFP for HACE1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HACE1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HACE1 | | | OriGene Protein Over-expression Lysate for HACE1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HACE1 | | OriGene 3'-UTR Clone for HACE1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HACE1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HACE1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HACE1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HACE1 | | OriGene Custom Protein Services for HACE1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HACE1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HACE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HACE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HACE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HACE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HACE1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for HACE1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | HACE1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HACE1 |
|  |  |  | | | | Search ThermoFisher Antibodies for HACE1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HACE1 |
|
|
|
|
