Aliases for HACE1 Gene
External Ids for HACE1 Gene
Previous GeneCards Identifiers for HACE1 Gene
GeneCards Summary for HACE1 Gene
HACE1 (HECT Domain And Ankyrin Repeat Containing E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with HACE1 include neuroblastoma. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and SMAD Signaling Network. GO annotations related to this gene include ligase activity and Rab GTPase binding. An important paralog of this gene is HERC2.
UniProtKB/Swiss-Prot for HACE1 Gene
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.