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Aliases for HACE1 Gene

Aliases for HACE1 Gene

  • HECT Domain And Ankyrin Repeat Containing E3 Ubiquitin Protein Ligase 1 2 3 5
  • HECT-Type E3 Ubiquitin Transferase HACE1 3 4
  • HECT Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1 4
  • E3 Ubiquitin-Protein Ligase HACE1 3
  • EC 2.3.2.26 4
  • KIAA1320 4
  • EC 6.3.2 61
  • SPPRS 3

External Ids for HACE1 Gene

Previous GeneCards Identifiers for HACE1 Gene

  • GC06M105176
  • GC06M105221
  • GC06M105282
  • GC06M102619

Summaries for HACE1 Gene

Entrez Gene Summary for HACE1 Gene

  • This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016]

GeneCards Summary for HACE1 Gene

HACE1 (HECT Domain And Ankyrin Repeat Containing E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with HACE1 include Spastic Paraplegia-Severe Developmental Delay-Epilepsy Syndrome and Neuroblastoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and Rab GTPase binding. An important paralog of this gene is HECW1.

UniProtKB/Swiss-Prot for HACE1 Gene

  • E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HACE1 Gene

Genomics for HACE1 Gene

Regulatory Elements for HACE1 Gene

Enhancers for HACE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G105793 1.3 Ensembl ENCODE dbSUPER 12 -934.1 -934111 1.8 HDGF RAD21 ZBTB40 RARA YY1 SMARCC2 RELB IKZF2 CEBPB REST HACE1 PRDM1 GC06M105786 LOC105377923
GH06G104858 1.1 ENCODE 11.9 +0.4 368 2.0 HNRNPUL1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 KLF13 HACE1 ENSG00000227535
GH06G105536 0.9 ENCODE 11.5 -677.0 -677048 1.7 ZNF493 ZFP64 FEZF1 ZNF138 KLF7 ZNF202 ZNF680 ZNF654 ZBTB11 ZNF426 HACE1 GC06M105534 GC06M105533 GC06P105593
GH06G104951 2 FANTOM5 Ensembl ENCODE dbSUPER 5 -96.0 -96000 8.5 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 LIN28B LIN28B-AS1 HACE1 RNU6-1106P GC06M105046
GH06G104789 0.9 Ensembl ENCODE 10.9 +69.9 69909 0.6 ELF3 CTCF ZNF654 TRIM22 ZNF384 REST TBX21 RAD21 CTBP1 ZNF157 HACE1 RNU6-897P ENSG00000227535
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HACE1 on UCSC Golden Path with GeneCards custom track

Promoters for HACE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000200385 319 1600 HNRNPUL1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 KLF13

Genomic Location for HACE1 Gene

Chromosome:
6
Start:
104,682,659 bp from pter
End:
104,859,919 bp from pter
Size:
177,261 bases
Orientation:
Minus strand

Genomic View for HACE1 Gene

Genes around HACE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HACE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HACE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HACE1 Gene

Proteins for HACE1 Gene

  • Protein details for HACE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYU2-HACE1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase HACE1
    Protein Accession:
    Q8IYU2
    Secondary Accessions:
    • A8K6U5
    • B3KY89
    • B4DFM6
    • B4DTQ4
    • B7Z9X6
    • E9PGP0
    • Q5VU99
    • Q5VUA0
    • Q8ND12
    • Q9P2M6

    Protein attributes for HACE1 Gene

    Size:
    909 amino acids
    Molecular mass:
    102342 Da
    Quaternary structure:
    • Interacts with RARB (By similarity). Interacts with RAB1 (RAB1A, RAB1B or RAB1C), RAB4 (RAB4A or RAB4B) and RAB11 (RAB11A or RAB11B); in a GTP-dependent manner. Interacts with RAC1; in a GTP-dependent manner. Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.
    SequenceCaution:
    • Sequence=BAA92558.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG57487.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG62066.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAH14462.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH71890.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH74024.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16815.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for HACE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HACE1 Gene

Selected DME Specific Peptides for HACE1 Gene

Q8IYU2:
  • LLQFVTGSSRVP
  • YFTRSFYKHILG
  • TFSVETD
  • LPTSSTC
  • ENDILLVHRDSIFRSSCE

Post-translational modifications for HACE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for HACE1 Gene

Gene Families for HACE1 Gene

Suggested Antigen Peptide Sequences for HACE1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HACE1: view

No data available for UniProtKB/Swiss-Prot for HACE1 Gene

Function for HACE1 Gene

Molecular function for HACE1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
UniProtKB/Swiss-Prot Induction:
Down-regulated in sporadic Wilms tumor.

Enzyme Numbers (IUBMB) for HACE1 Gene

Gene Ontology (GO) - Molecular Function for HACE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA,IEA 21988917
GO:0005515 protein binding IPI 25026213
GO:0016740 transferase activity IEA --
GO:0017137 Rab GTPase binding IDA 21988917
GO:0048365 Rac GTPase binding IPI 22036506
genes like me logo Genes that share ontologies with HACE1: view
genes like me logo Genes that share phenotypes with HACE1: view

Human Phenotype Ontology for HACE1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HACE1 Gene

MGI Knock Outs for HACE1:

Animal Model Products

CRISPR Products

miRNA for HACE1 Gene

miRTarBase miRNAs that target HACE1

Inhibitory RNA Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for HACE1 Gene

Localization for HACE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HACE1 Gene

Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HACE1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for HACE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 21988917
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HACE1: view

Pathways & Interactions for HACE1 Gene

genes like me logo Genes that share pathways with HACE1: view

UniProtKB/Swiss-Prot Q8IYU2-HACE1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for HACE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007030 Golgi organization IDA 21988917
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IDA,IEA 21988917
genes like me logo Genes that share ontologies with HACE1: view

No data available for SIGNOR curated interactions for HACE1 Gene

Drugs & Compounds for HACE1 Gene

No Compound Related Data Available

Transcripts for HACE1 Gene

Unigene Clusters for HACE1 Gene

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HACE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^
SP1: - -
SP2: - - - - - - -
SP3: -
SP4:

ExUns: 24a · 24b · 24c
SP1:
SP2:
SP3:
SP4:

Relevant External Links for HACE1 Gene

GeneLoc Exon Structure for
HACE1
ECgene alternative splicing isoforms for
HACE1

Expression for HACE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HACE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HACE1 Gene

This gene is overexpressed in Bone marrow stromal cell (18.9) and Retina (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HACE1 Gene



NURSA nuclear receptor signaling pathways regulating expression of HACE1 Gene:

HACE1

SOURCE GeneReport for Unigene cluster for HACE1 Gene:

Hs.434340

mRNA Expression by UniProt/SwissProt for HACE1 Gene:

Q8IYU2-HACE1_HUMAN
Tissue specificity: Expressed in multiple tissues including heart, brain and kidney.

Evidence on tissue expression from TISSUES for HACE1 Gene

  • Nervous system(4.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HACE1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • heart
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • adrenal gland
  • intestine
  • kidney
  • large intestine
  • small intestine
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • spinal cord
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with HACE1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for HACE1 Gene

Orthologs for HACE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HACE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HACE1 34 35
  • 99.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HACE1 34 35
  • 95.2 (n)
cow
(Bos Taurus)
Mammalia HACE1 34 35
  • 95.09 (n)
oppossum
(Monodelphis domestica)
Mammalia HACE1 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hace1 34 16 35
  • 90.98 (n)
rat
(Rattus norvegicus)
Mammalia Hace1 34
  • 88.6 (n)
chicken
(Gallus gallus)
Aves HACE1 34 35
  • 84.75 (n)
lizard
(Anolis carolinensis)
Reptilia HACE1 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hace1 34
  • 80.27 (n)
Str.20391 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.22891 34
zebrafish
(Danio rerio)
Actinopterygii hace1 34 35
  • 74.05 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM1 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToOne
Species where no ortholog for HACE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HACE1 Gene

ENSEMBL:
Gene Tree for HACE1 (if available)
TreeFam:
Gene Tree for HACE1 (if available)

Paralogs for HACE1 Gene

Variants for HACE1 Gene

Sequence variations from dbSNP and Humsavar for HACE1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs750371878 Pathogenic 104,796,666(+) TTCTC(A/G)GAGGT nc-transcript-variant, reference, stop-gained
rs751809418 Pathogenic 104,776,752(+) CTGAC(-/TG)GGTAA nc-transcript-variant, reference, frameshift-variant
rs761086584 Pathogenic 104,849,228(+) ACCAA(A/G/T)CATTC nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs869025280 Pathogenic 104,796,988(-) TATTA(C/T)GAGGA nc-transcript-variant, reference, stop-gained
rs869025281 Pathogenic 104,750,442(-) AACTT(C/T)GAATG nc-transcript-variant, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for HACE1 Gene

Variant ID Type Subtype PubMed ID
dgv10889n54 CNV loss 21841781
dgv10890n54 CNV loss 21841781
dgv10891n54 CNV loss 21841781
dgv10892n54 CNV loss 21841781
dgv10893n54 CNV loss 21841781
dgv10894n54 CNV loss 21841781
dgv187n73 CNV deletion 24416366
dgv3355n106 CNV deletion 24896259
esv1963512 CNV deletion 18987734
esv2463529 CNV deletion 19546169
esv2518204 CNV deletion 19546169
esv2664784 CNV deletion 23128226
esv2732530 CNV deletion 23290073
esv2732531 CNV deletion 23290073
esv2759461 CNV gain 17122850
esv27932 CNV loss 19812545
esv3540253 CNV deletion 23714750
esv3540254 CNV deletion 23714750
esv3610247 CNV loss 21293372
nsv1022692 CNV loss 25217958
nsv1024939 CNV loss 25217958
nsv1028763 CNV gain 25217958
nsv1074003 CNV deletion 25765185
nsv1137133 CNV deletion 24896259
nsv464020 CNV loss 19166990
nsv499549 CNV loss 21111241
nsv511348 CNV loss 21212237
nsv511909 CNV loss 21212237
nsv514383 CNV loss 21397061
nsv5420 CNV deletion 18451855
nsv5422 CNV deletion 18451855
nsv5423 CNV insertion 18451855
nsv604402 CNV loss 21841781
nsv604421 CNV loss 21841781
nsv604430 CNV loss 21841781
nsv7949 CNV loss 18304495
nsv823812 CNV gain 20364138

Variation tolerance for HACE1 Gene

Residual Variation Intolerance Score: 5.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HACE1 Gene

Human Gene Mutation Database (HGMD)
HACE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HACE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HACE1 Gene

Disorders for HACE1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HACE1 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia-severe developmental delay-epilepsy syndrome
  • spprs syndrome
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search HACE1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HACE1_HUMAN
  • Note=Defects in HACE1 are a cause of Wilms tumor (WT). WT is a pediatric malignancy of kidney and one of the most common solid cancers in childhood. HACE1 is epigenetically down-regulated in sporadic Wilms tumor. Moreover, a t(5;6)(q21;q21) translocation that truncates HACE1 has been found in a child with bilateral, young-onset Wilms tumor (PubMed:19948536). {ECO:0000269 PubMed:17694067, ECO:0000269 PubMed:19948536}.
  • Spastic paraplegia and psychomotor retardation with or without seizures (SPPRS) [MIM:616756]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPPRS is an autosomal recessive neurodevelopmental disorder manifesting in infancy. Affected individuals show hypotonia and psychomotor retardation. Most develop seizures. {ECO:0000269 PubMed:26424145, ECO:0000269 PubMed:26437029}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HACE1

Genetic Association Database (GAD)
HACE1
Human Genome Epidemiology (HuGE) Navigator
HACE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HACE1
genes like me logo Genes that share disorders with HACE1: view

No data available for Genatlas for HACE1 Gene

Publications for HACE1 Gene

  1. Differential expression of a novel ankyrin containing E3 ubiquitin- protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. (PMID: 15254018) Anglesio M.S. … Sorensen P.H.B. (Hum. Mol. Genet. 2004) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. HACE1 deficiency causes an autosomal recessive neurodevelopmental syndrome. (PMID: 26424145) Hollstein R. … Bonthron D.T. (J. Med. Genet. 2015) 3 4 64
  4. The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle. (PMID: 21988917) Tang D. … Wang Y. (Nat. Commun. 2011) 3 4 64
  5. The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1. (PMID: 22036506) Torrino S. … Lemichez E. (Dev. Cell 2011) 3 4 64

Products for HACE1 Gene

Sources for HACE1 Gene

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